TYR_TEK (Angiopoietin-1 receptor)

Total number of chains: 13
Active chains: 2
Family: TYR
Uniprot: TIE2_HUMAN
Kinase Domain Residues: 824 - 1094
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 5 38.5% 6MWEA
DFGout None 3 23.1% 2WQBA
DFGin BLAminus 2 15.4% AF-Q02763-K1A
DFGinter BABtrans 2 15.4% 1FVRB
DFGin BLBplus 1 7.7% 3L8PA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q02763-K1A 816 1102 1124.0 No_ligand No_ligand Active DFGin 6.913 13.98 BLAminus -133.48, -174.0 54.21, 70.93 -87.59, 10.68 289.57, 88.01 -60.0, -27.88 in-in in 7.769 Saltbr-in 2.651 HRD-in -73.72, -44.29 66.86, -19.94 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.33, 68.83 APE9-dihe-in -111.72, 150.32 APE8-dihe-in -78.18, 98.69 APE8-rot-na 37.69 APE67-dihe-in -66.81, -16.71 -43.2, -41.32 APE12-dist-na 14.696 APE11-dist-na 9.918 APE10-dist-na 9.161 APE9-dist-in 5.856 None None None AF2 -1.0 1.0 1.0 A 287 287 0 0 0 0 [[824, 1094]] 1.0 AF-Q02763-K1 TYR_TEK_HUMAN TYR 5.2e-91 310.5 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
AF-Q02763-K3A 816 1102 1124.0 No_ligand No_ligand Active DFGin 6.571 13.861 BLAminus -139.12, -178.86 59.54, 65.32 -79.92, 10.15 291.06, 92.62 -59.9, -29.8 in-in in 7.805 Saltbr-in 2.692 HRD-in -81.22, -46.83 67.42, -8.27 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.36, 137.88 APE9-dihe-in -141.41, 142.16 APE8-dihe-in -82.04, 60.9 APE8-rot-na 36.65 APE67-dihe-in -65.75, -17.72 -43.1, -41.64 APE12-dist-na 14.627 APE11-dist-na 11.008 APE10-dist-na 10.329 APE9-dist-in 6.877 None None None AF2 -1.0 1.0 1.0 A 287 287 0 0 0 0 [[824, 1094]] 1.0 AF-Q02763-K3 TYR_TEK_HUMAN TYR 5.2e-91 310.5 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
3L8PA 814 1121 1124.0 0CE:2207 Type1 Inactive DFGin 6.305 12.822 BLBplus -131.84, 173.07 50.13, 38.25 -83.89, 143.24 46.58, 85.25 -61.61, 145.15 out-out out 13.713 Saltbr-out 8.577 HRD-in -62.84, -55.45 79.44, -13.24 out-out-none SNCoon out-none ActLoopNT-out 6.595 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 22.9 APE8-rot-na 35.17 APE67-dihe-in -67.48, -18.66 -48.88, -39.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.239 0.265 A 317 292 16 0 0 5 [[824, 1094]] 1.0 3l8p TYR_TEK_HUMAN TYR 7.5e-91 310.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
1FVRA 813 1121 1124.0 No_ligand No_ligand Inactive DFGinter 8.417 7.259 BABtrans -70.32, 127.73 -127.01, 36.72 -94.99, 138.29 184.97, 79.8 67.05, 29.11 out-out out 10.373 Saltbr-out 7.44 HRD-in -69.68, -50.63 81.63, -26.26 out-out-out SNCooo out-out ActLoopNT-out 5.117 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.88 APE8-dihe-in -75.53, 55.91 APE8-rot-na 38.59 APE67-dihe-in -71.29, -9.41 -46.42, -37.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.515 None None None XRAY 2.2 0.195 0.225 A 327 299 10 0 0 4 [[824, 1094]] 1.0 1fvr TYR_TEK_HUMAN TYR 8.3e-91 309.8 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
1FVRB 813 1121 1124.0 No_ligand No_ligand Inactive DFGinter 8.59 7.184 BABtrans -71.55, 125.08 -125.14, 43.48 -101.19, 137.55 183.68, 81.8 68.42, 28.27 out-out out 10.101 Saltbr-out 7.6 HRD-in -66.4, -52.26 80.81, -19.06 out-out-out SNCooo out-out ActLoopNT-out 5.131 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -27.62 APE9-dihe-in -107.96, 129.21 APE8-dihe-in -75.73, 57.96 APE8-rot-na 37.26 APE67-dihe-in -64.73, -13.95 -46.88, -41.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.261 APE9-dist-out 8.643 None None None XRAY 2.2 0.195 0.225 B 327 300 9 0 0 3 [[824, 1094]] 1.0 1fvr TYR_TEK_HUMAN TYR 8.3e-91 309.8 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
2OO8X 836 1117 1124.0 RAJ:1 Type2 Inactive DFGout 13.686 11.565 BBAminus -141.23, -175.17 -157.19, 106.22 -93.02, -5.95 306.19, 116.1 100.24, 168.01 in-out in 8.224 Saltbr-out 3.724 HRD-in -73.61, -56.09 86.36, -12.36 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -59.67, 136.27 APE9-dihe-in -66.67, 134.11 APE8-dihe-in -77.33, 61.61 APE8-rot-na 28.28 APE67-dihe-in -63.37, -19.26 -45.51, -46.51 APE12-dist-na 9.081 APE11-dist-na 5.185 APE10-dist-na 7.128 APE9-dist-out 8.332 None None None XRAY 2.2 0.235 0.279 X 317 259 35 0 0 11 [[824, 1094]] 1.0 2oo8 TYR_TEK_HUMAN TYR 7.5e-91 310.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
2OSCA 837 1116 1124.0 MUH:50 Type2 Inactive DFGout 13.662 11.504 BBAminus -142.39, -172.83 -162.1, 104.7 -90.66, -7.86 308.26, 123.26 108.92, 160.71 in-in in 8.529 Saltbr-in 2.783 HRD-in -75.78, -47.04 76.34, -16.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -58.37, 161.58 APE9-dihe-in -78.17, 144.94 APE8-dihe-in -74.87, 55.92 APE8-rot-na 33.59 APE67-dihe-in -63.44, -19.17 -43.09, -44.17 APE12-dist-na 9.33 APE11-dist-na 5.285 APE10-dist-na 8.064 APE9-dist-out 8.355 None None None XRAY 2.8 0.251 0.306 A 317 255 38 0 0 11 [[824, 1094]] 1.0 2osc TYR_TEK_HUMAN TYR 7.5e-91 310.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
2P4IA 838 1117 1124.0 MR9:301 Type2 Inactive DFGout 14.021 11.701 BBAminus -136.32, 173.59 -145.12, 114.01 -102.79, 17.92 301.53, 118.36 -72.3, 179.27 in-in in 7.975 Saltbr-in 2.726 HRD-in -73.36, -56.61 72.87, 3.4 in-out-in SNCioi out-in ActLoopNT-out 9.831 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.42, 131.65 APE9-dihe-in -72.54, 124.34 APE8-dihe-in -83.03, 79.81 APE8-rot-na 33.61 APE67-dihe-in -69.75, -16.36 -61.46, -37.5 APE12-dist-na 12.762 APE11-dist-na 10.102 APE10-dist-na 12.678 APE9-dist-in 7.369 None None None XRAY 2.5 0.248 0.303 A 317 252 42 0 0 5 [[824, 1094]] 1.0 2p4i TYR_TEK_HUMAN TYR 7.5e-91 310.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
6MWEA 816 1122 1124.0 919:1203 Type2 Inactive DFGout 13.354 10.606 BBAminus -139.56, 179.54 -155.41, 121.99 -100.36, 10.81 282.44, 103.03 91.89, 0.35 in-in in 7.559 Saltbr-in 2.482 HRD-in -71.19, -54.67 81.44, -10.36 in-out-out SNCioo out-out ActLoopNT-out 10.543 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -91.4, -5.72 APE9-dihe-out -57.22, -41.43 APE8-dihe-out -59.21, -21.01 APE8-rot-na 337.82 APE67-dihe-in -71.75, -11.24 -48.45, -35.17 APE12-dist-na 11.38 APE11-dist-na 8.608 APE10-dist-na 12.561 APE9-dist-out 10.785 None None None XRAY 2.05 0.149 0.166 A 317 292 15 0 0 2 [[824, 1094]] 1.0 6mwe TYR_TEK_HUMAN TYR 7.5e-91 310.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
6MWEB 816 1122 1124.0 919:1203 Type2 Inactive DFGout 13.396 10.504 BBAminus -136.71, -178.85 -151.95, 121.17 -94.08, 7.28 284.75, 97.66 92.39, -1.76 in-in in 7.559 Saltbr-in 2.585 HRD-in -68.95, -51.62 79.52, -11.84 in-out-out SNCioo out-out ActLoopNT-out 10.416 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -91.44, -0.78 APE9-dihe-out -58.14, -40.06 APE8-dihe-out -58.25, -21.33 APE8-rot-na 337.67 APE67-dihe-in -69.06, -11.94 -47.55, -40.23 APE12-dist-na 10.96 APE11-dist-na 7.939 APE10-dist-na 11.818 APE9-dist-out 10.902 None None None XRAY 2.05 0.149 0.166 B 317 290 17 0 0 3 [[824, 1094]] 1.0 6mwe TYR_TEK_HUMAN TYR 7.5e-91 310.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
2WQBA 816 1120 1124.0 QQ1:2121 Type1 Inactive DFGout 12.585 8.927 None -94.98, 119.31 -85.34, 13.79 -87.2, 146.48 339.31, 111.25 49.09, 64.24 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.77, -59.46 75.89, 2.81 none-out-out SNCnoo out-out ActLoopNT-out 5.479 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -113.11, 143.74 APE9-dihe-in -89.99, 140.55 APE8-dihe-in -71.24, 55.33 APE8-rot-na 25.5 APE67-dihe-in -62.19, -17.52 -45.52, -49.23 APE12-dist-na 999.0 APE11-dist-na 17.924 APE10-dist-na 18.83 APE9-dist-out 8.53 D964N None None XRAY 2.95 0.199 0.259 A 324 289 16 0 0 1 [[824, 1094]] 1.0 2wqb TYR_TEK_HUMAN TYR 3.1e-90 308.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
2P4IB 836 1117 1124.0 MR9:302 Type2 Inactive DFGout 13.745 12.067 None -139.3, -178.13 -154.85, 99.11 -89.78, -137.59 304.87, 121.9 -63.46, 135.48 in-in in 8.274 Saltbr-in 2.713 HRD-in -82.09, -49.46 82.5, -17.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -159.33, 129.69 APE9-dihe-in -65.42, 134.93 APE8-dihe-in -78.37, 56.52 APE8-rot-na 29.79 APE67-dihe-in -64.93, -9.37 -32.69, -53.4 APE12-dist-na 999.0 APE11-dist-na 6.754 APE10-dist-na 8.149 APE9-dist-out 8.234 None None None XRAY 2.5 0.248 0.303 B 317 258 36 0 0 12 [[824, 1094]] 1.0 2p4i TYR_TEK_HUMAN TYR 7.5e-91 310.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
4X3JA 838 1117 1124.0 3WR:1201 Type2 Inactive DFGout 14.059 12.012 None -141.88, 178.62 -157.12, 97.09 -145.59, 158.59 57.15, 88.38 -143.92, 999.0 in-out in 8.304 Saltbr-out 3.919 HRD-in -67.48, -51.33 75.0, -7.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.56 APE8-dihe-in -85.68, 63.2 APE8-rot-na 34.61 APE67-dihe-in -57.24, -24.52 -43.48, -49.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.232 D964N None None XRAY 2.5 0.257 0.293 A 321 234 60 0 0 15 [[824, 1094]] 1.0 4x3j TYR_TEK_HUMAN TYR 3e-90 308.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor

TYR_TEK (Angiopoietin-1 receptor)

Total number of chains: 13
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 5 38.5% 6MWEA
DFGout None 3 23.1% 2WQBA
DFGin BLAminus 2 15.4% AF-Q02763-K1A
DFGinter BABtrans 2 15.4% 1FVRB
DFGin BLBplus 1 7.7% 3L8PA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TIE2_HUMAN AF-Q02763-K1A Q02763 816 1102 1124.0 No_ligand No_ligand Active DFGin 6.913 13.98 BLAminus -133.48, -174.0 54.21, 70.93 -87.59, 10.68 289.57, 88.01 -60.0, -27.88 in-in in 7.769 Saltbr-in 2.651 HRD-in -73.72, -44.29 66.86, -19.94 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.33, 68.83 APE9-dihe-in -111.72, 150.32 APE8-dihe-in -78.18, 98.69 APE8-rot-na 37.69 APE67-dihe-in -66.81, -16.71 -43.2, -41.32 APE12-dist-na 14.696 APE11-dist-na 9.918 APE10-dist-na 9.161 APE9-dist-in 5.856 None None None AF2 -1.0 1.0 1.0 A 287 287 0 0 0 0 [[824, 1094]] 1.0 AF-Q02763-K1 Homo sapiens TYR_TEK_HUMAN TYR 5.2e-91 310.5 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TIE2_HUMAN AF-Q02763-K3A Q02763 816 1102 1124.0 No_ligand No_ligand Active DFGin 6.571 13.861 BLAminus -139.12, -178.86 59.54, 65.32 -79.92, 10.15 291.06, 92.62 -59.9, -29.8 in-in in 7.805 Saltbr-in 2.692 HRD-in -81.22, -46.83 67.42, -8.27 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.36, 137.88 APE9-dihe-in -141.41, 142.16 APE8-dihe-in -82.04, 60.9 APE8-rot-na 36.65 APE67-dihe-in -65.75, -17.72 -43.1, -41.64 APE12-dist-na 14.627 APE11-dist-na 11.008 APE10-dist-na 10.329 APE9-dist-in 6.877 None None None AF2 -1.0 1.0 1.0 A 287 287 0 0 0 0 [[824, 1094]] 1.0 AF-Q02763-K3 Homo sapiens TYR_TEK_HUMAN TYR 5.2e-91 310.5 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TIE2_HUMAN 3L8PA Q02763 814 1121 1124.0 0CE:2207 Type1 Inactive DFGin 6.305 12.822 BLBplus -131.84, 173.07 50.13, 38.25 -83.89, 143.24 46.58, 85.25 -61.61, 145.15 out-out out 13.713 Saltbr-out 8.577 HRD-in -62.84, -55.45 79.44, -13.24 out-out-none SNCoon out-none ActLoopNT-out 6.595 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 22.9 APE8-rot-na 35.17 APE67-dihe-in -67.48, -18.66 -48.88, -39.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.239 0.265 A 317 292 16 0 0 5 [[824, 1094]] 1.0 3l8p Homo sapiens TYR_TEK_HUMAN TYR 7.5e-91 310.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TIE2_HUMAN 1FVRA Q02763 813 1121 1124.0 No_ligand No_ligand Inactive DFGinter 8.417 7.259 BABtrans -70.32, 127.73 -127.01, 36.72 -94.99, 138.29 184.97, 79.8 67.05, 29.11 out-out out 10.373 Saltbr-out 7.44 HRD-in -69.68, -50.63 81.63, -26.26 out-out-out SNCooo out-out ActLoopNT-out 5.117 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.88 APE8-dihe-in -75.53, 55.91 APE8-rot-na 38.59 APE67-dihe-in -71.29, -9.41 -46.42, -37.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.515 None None None XRAY 2.2 0.195 0.225 A 327 299 10 0 0 4 [[824, 1094]] 1.0 1fvr Homo sapiens TYR_TEK_HUMAN TYR 8.3e-91 309.8 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TIE2_HUMAN 1FVRB Q02763 813 1121 1124.0 No_ligand No_ligand Inactive DFGinter 8.59 7.184 BABtrans -71.55, 125.08 -125.14, 43.48 -101.19, 137.55 183.68, 81.8 68.42, 28.27 out-out out 10.101 Saltbr-out 7.6 HRD-in -66.4, -52.26 80.81, -19.06 out-out-out SNCooo out-out ActLoopNT-out 5.131 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -27.62 APE9-dihe-in -107.96, 129.21 APE8-dihe-in -75.73, 57.96 APE8-rot-na 37.26 APE67-dihe-in -64.73, -13.95 -46.88, -41.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.261 APE9-dist-out 8.643 None None None XRAY 2.2 0.195 0.225 B 327 300 9 0 0 3 [[824, 1094]] 1.0 1fvr Homo sapiens TYR_TEK_HUMAN TYR 8.3e-91 309.8 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TIE2_HUMAN 2OO8X Q02763 836 1117 1124.0 RAJ:1 Type2 Inactive DFGout 13.686 11.565 BBAminus -141.23, -175.17 -157.19, 106.22 -93.02, -5.95 306.19, 116.1 100.24, 168.01 in-out in 8.224 Saltbr-out 3.724 HRD-in -73.61, -56.09 86.36, -12.36 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -59.67, 136.27 APE9-dihe-in -66.67, 134.11 APE8-dihe-in -77.33, 61.61 APE8-rot-na 28.28 APE67-dihe-in -63.37, -19.26 -45.51, -46.51 APE12-dist-na 9.081 APE11-dist-na 5.185 APE10-dist-na 7.128 APE9-dist-out 8.332 None None None XRAY 2.2 0.235 0.279 X 317 259 35 0 0 11 [[824, 1094]] 1.0 2oo8 Homo sapiens TYR_TEK_HUMAN TYR 7.5e-91 310.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TIE2_HUMAN 2OSCA Q02763 837 1116 1124.0 MUH:50 Type2 Inactive DFGout 13.662 11.504 BBAminus -142.39, -172.83 -162.1, 104.7 -90.66, -7.86 308.26, 123.26 108.92, 160.71 in-in in 8.529 Saltbr-in 2.783 HRD-in -75.78, -47.04 76.34, -16.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -58.37, 161.58 APE9-dihe-in -78.17, 144.94 APE8-dihe-in -74.87, 55.92 APE8-rot-na 33.59 APE67-dihe-in -63.44, -19.17 -43.09, -44.17 APE12-dist-na 9.33 APE11-dist-na 5.285 APE10-dist-na 8.064 APE9-dist-out 8.355 None None None XRAY 2.8 0.251 0.306 A 317 255 38 0 0 11 [[824, 1094]] 1.0 2osc Homo sapiens TYR_TEK_HUMAN TYR 7.5e-91 310.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TIE2_HUMAN 2P4IA Q02763 838 1117 1124.0 MR9:301 Type2 Inactive DFGout 14.021 11.701 BBAminus -136.32, 173.59 -145.12, 114.01 -102.79, 17.92 301.53, 118.36 -72.3, 179.27 in-in in 7.975 Saltbr-in 2.726 HRD-in -73.36, -56.61 72.87, 3.4 in-out-in SNCioi out-in ActLoopNT-out 9.831 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.42, 131.65 APE9-dihe-in -72.54, 124.34 APE8-dihe-in -83.03, 79.81 APE8-rot-na 33.61 APE67-dihe-in -69.75, -16.36 -61.46, -37.5 APE12-dist-na 12.762 APE11-dist-na 10.102 APE10-dist-na 12.678 APE9-dist-in 7.369 None None None XRAY 2.5 0.248 0.303 A 317 252 42 0 0 5 [[824, 1094]] 1.0 2p4i Homo sapiens TYR_TEK_HUMAN TYR 7.5e-91 310.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TIE2_HUMAN 6MWEA Q02763 816 1122 1124.0 919:1203 Type2 Inactive DFGout 13.354 10.606 BBAminus -139.56, 179.54 -155.41, 121.99 -100.36, 10.81 282.44, 103.03 91.89, 0.35 in-in in 7.559 Saltbr-in 2.482 HRD-in -71.19, -54.67 81.44, -10.36 in-out-out SNCioo out-out ActLoopNT-out 10.543 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -91.4, -5.72 APE9-dihe-out -57.22, -41.43 APE8-dihe-out -59.21, -21.01 APE8-rot-na 337.82 APE67-dihe-in -71.75, -11.24 -48.45, -35.17 APE12-dist-na 11.38 APE11-dist-na 8.608 APE10-dist-na 12.561 APE9-dist-out 10.785 None None None XRAY 2.05 0.149 0.166 A 317 292 15 0 0 2 [[824, 1094]] 1.0 6mwe Homo sapiens TYR_TEK_HUMAN TYR 7.5e-91 310.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TIE2_HUMAN 6MWEB Q02763 816 1122 1124.0 919:1203 Type2 Inactive DFGout 13.396 10.504 BBAminus -136.71, -178.85 -151.95, 121.17 -94.08, 7.28 284.75, 97.66 92.39, -1.76 in-in in 7.559 Saltbr-in 2.585 HRD-in -68.95, -51.62 79.52, -11.84 in-out-out SNCioo out-out ActLoopNT-out 10.416 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -91.44, -0.78 APE9-dihe-out -58.14, -40.06 APE8-dihe-out -58.25, -21.33 APE8-rot-na 337.67 APE67-dihe-in -69.06, -11.94 -47.55, -40.23 APE12-dist-na 10.96 APE11-dist-na 7.939 APE10-dist-na 11.818 APE9-dist-out 10.902 None None None XRAY 2.05 0.149 0.166 B 317 290 17 0 0 3 [[824, 1094]] 1.0 6mwe Homo sapiens TYR_TEK_HUMAN TYR 7.5e-91 310.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TIE2_HUMAN 2WQBA Q02763 816 1120 1124.0 QQ1:2121 Type1 Inactive DFGout 12.585 8.927 None -94.98, 119.31 -85.34, 13.79 -87.2, 146.48 339.31, 111.25 49.09, 64.24 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.77, -59.46 75.89, 2.81 none-out-out SNCnoo out-out ActLoopNT-out 5.479 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -113.11, 143.74 APE9-dihe-in -89.99, 140.55 APE8-dihe-in -71.24, 55.33 APE8-rot-na 25.5 APE67-dihe-in -62.19, -17.52 -45.52, -49.23 APE12-dist-na 999.0 APE11-dist-na 17.924 APE10-dist-na 18.83 APE9-dist-out 8.53 D964N None None XRAY 2.95 0.199 0.259 A 324 289 16 0 0 1 [[824, 1094]] 1.0 2wqb Homo sapiens TYR_TEK_HUMAN TYR 3.1e-90 308.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TIE2_HUMAN 2P4IB Q02763 836 1117 1124.0 MR9:302 Type2 Inactive DFGout 13.745 12.067 None -139.3, -178.13 -154.85, 99.11 -89.78, -137.59 304.87, 121.9 -63.46, 135.48 in-in in 8.274 Saltbr-in 2.713 HRD-in -82.09, -49.46 82.5, -17.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -159.33, 129.69 APE9-dihe-in -65.42, 134.93 APE8-dihe-in -78.37, 56.52 APE8-rot-na 29.79 APE67-dihe-in -64.93, -9.37 -32.69, -53.4 APE12-dist-na 999.0 APE11-dist-na 6.754 APE10-dist-na 8.149 APE9-dist-out 8.234 None None None XRAY 2.5 0.248 0.303 B 317 258 36 0 0 12 [[824, 1094]] 1.0 2p4i Homo sapiens TYR_TEK_HUMAN TYR 7.5e-91 310.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TIE2_HUMAN 4X3JA Q02763 838 1117 1124.0 3WR:1201 Type2 Inactive DFGout 14.059 12.012 None -141.88, 178.62 -157.12, 97.09 -145.59, 158.59 57.15, 88.38 -143.92, 999.0 in-out in 8.304 Saltbr-out 3.919 HRD-in -67.48, -51.33 75.0, -7.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.56 APE8-dihe-in -85.68, 63.2 APE8-rot-na 34.61 APE67-dihe-in -57.24, -24.52 -43.48, -49.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.232 D964N None None XRAY 2.5 0.257 0.293 A 321 234 60 0 0 15 [[824, 1094]] 1.0 4x3j Homo sapiens TYR_TEK_HUMAN TYR 3e-90 308.0 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor

TYR_TEK (Angiopoietin-1 receptor)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name