STE_STK10 (Serine/threonine-protein kinase 10)

Total number of chains: 27
Active chains: 3
Family: STE
Uniprot: STK10_HUMAN
Kinase Domain Residues: 36 - 294
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 33.3% AF-O94804-K1A
DFGout None 8 29.6% 4EQUB
DFGout BBAminus 3 11.1% 6EIMB
DFGin ABAminus 2 7.4% 4USEA
DFGin None 2 7.4% 5AJQA
None None 2 7.4% 5OWQB
DFGin BLBminus 1 3.7% 7QGPA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-O94804-K1A 28 302 968.0 No_ligand No_ligand Active DFGin 6.452 14.249 BLAminus -135.71, 176.66 59.25, 66.38 -82.18, 11.09 287.41, 80.75 -59.47, -31.26 in-in in 8.534 Saltbr-in 2.824 HRD-in -71.19, -46.57 66.11, -8.52 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.89, 150.24 APE9-dihe-na 128.53, 173.67 APE8-dihe-in -80.96, 122.95 APE8-rot-in 304.51 APE67-dihe-in -72.34, -25.41 -48.31, -39.05 APE12-dist-in 9.025 APE11-dist-in 11.887 APE10-dist-in 6.129 APE9-dist-in 3.523 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[36, 294]] 1.0 AF-O94804-K1 STE_STK10_HUMAN STE 1.4e-94 322.1 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
AF-O94804-K3A 28 302 968.0 No_ligand No_ligand Active DFGin 6.224 14.62 BLAminus -134.36, -179.98 56.11, 76.53 -90.84, 11.03 290.99, 80.96 -61.5, -19.4 in-in in 9.137 Saltbr-in 2.877 HRD-in -72.98, -44.73 68.12, -11.2 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.55, 136.15 APE9-dihe-na 139.96, 175.77 APE8-dihe-in -84.43, 126.08 APE8-rot-in 304.38 APE67-dihe-in -70.91, -25.3 -51.73, -37.71 APE12-dist-in 9.345 APE11-dist-in 11.725 APE10-dist-in 5.888 APE9-dist-in 3.354 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[36, 294]] 1.0 AF-O94804-K3 STE_STK10_HUMAN STE 1.4e-94 322.1 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
6HXFC 24 312 968.0 R70:401 Type1 Active DFGin 6.939 14.636 BLAminus -133.33, 174.27 55.01, 80.49 -91.62, 24.2 286.74, 75.79 -63.56, -43.2 in-in in 8.248 Saltbr-in 2.397 HRD-in -71.95, -49.91 71.21, -0.58 in-in-in SNCiii in-in ActLoopNT-in 3.008 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.89, 153.47 APE9-dihe-na 116.81, -165.08 APE8-dihe-in -105.94, 128.94 APE8-rot-in 311.81 APE67-dihe-in -64.78, -27.93 -51.25, -38.45 APE12-dist-in 8.899 APE11-dist-in 11.561 APE10-dist-in 6.007 APE9-dist-in 3.572 None TPO185,SEP191,TPO208 TPO185,SEP191,TPO208 XRAY 2.09 0.192 0.219 C 302 288 1 0 0 0 [[36, 294]] 1.0 6hxf STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
4USEA 24 316 968.0 R09:500 Type1 Inactive DFGin 6.667 16.312 ABAminus -124.06, -47.73 -111.47, 110.64 -107.37, 33.1 286.3, 80.35 -74.02, -29.24 in-out in 9.875 Saltbr-out 5.384 HRD-in -76.52, -50.26 63.76, 8.26 out-out-out SNCooo out-out ActLoopNT-out 5.88 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.21 APE8-rot-in 292.58 APE67-dihe-out -68.99, -19.32 -97.26, 50.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.226 0.251 A 302 286 7 0 0 7 [[36, 294]] 1.0 4use STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
4USEB 24 316 968.0 R09:500 Type1 Inactive DFGin 6.672 16.394 ABAminus -123.54, -48.03 -110.84, 111.05 -107.61, 33.16 286.69, 80.16 -75.08, -28.62 in-out in 9.894 Saltbr-out 5.358 HRD-in -76.02, -50.04 64.2, 8.63 out-out-out SNCooo out-out ActLoopNT-out 5.889 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -53.4 APE8-rot-in 294.34 APE67-dihe-out -69.37, -18.81 -96.21, 50.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.226 0.251 B 302 278 15 0 0 6 [[36, 294]] 1.0 4use STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
4BC6A 24 316 968.0 XZN:1317 Type1 Inactive DFGin 6.702 16.554 BLAminus -115.1, 176.1 50.46, 84.66 -96.24, 32.79 282.83, 79.72 -68.79, -52.65 in-out in 9.853 Saltbr-out 6.308 HRD-in -70.14, -48.74 64.67, 6.49 out-out-none SNCoon out-none ActLoopNT-out 5.794 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.41, -27.46 999.0, 17.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.214 0.254 A 293 285 8 0 0 8 [[36, 294]] 1.0 4bc6 STE_STK10_HUMAN STE 1.8e-94 321.8 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
2J7TA 25 317 968.0 274:1324 Type1 Inactive DFGin 6.693 16.261 BLAminus -130.09, 176.02 61.18, 79.65 -92.72, 22.97 287.66, 81.69 -62.25, -51.67 in-none in 9.552 Saltbr-none 999.0 HRD-in -71.07, -51.96 69.61, 2.63 none-out-out SNCnoo out-out ActLoopNT-out 5.787 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 999.0 APE9-dihe-na 130.26, -176.82 APE8-dihe-in -110.48, 131.85 APE8-rot-in 320.34 APE67-dihe-in -55.31, -32.25 -58.76, -42.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 21.531 APE9-dist-out 25.611 None None None XRAY 2.0 0.205 0.235 A 302 285 8 0 0 4 [[36, 294]] 1.0 2j7t STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
5OWRA 23 317 968.0 1N1:401 Type1 Inactive DFGin 6.498 16.722 BLAminus -126.18, 173.2 57.39, 79.01 -91.46, 24.21 286.72, 77.35 -53.02, -57.95 out-out out 10.205 Saltbr-out 8.136 HRD-in -70.96, -54.03 67.34, 13.9 out-out-none SNCoon out-none ActLoopNT-out 5.833 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.94, -27.24 999.0, -15.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.221 0.254 A 302 282 13 0 0 7 [[36, 294]] 1.0 5owr STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
6HXFA 24 313 968.0 R70:401 Type1 Inactive DFGin 6.852 14.805 BLAminus -130.96, 172.47 55.0, 81.54 -91.14, 24.47 285.61, 78.24 -62.74, -43.57 in-in in 8.131 Saltbr-in 2.679 HRD-in -69.16, -50.08 73.44, -2.15 in-out-out SNCioo out-out ActLoopNT-out 5.888 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -113.63, 135.13 APE9-dihe-na 71.67, -159.59 APE8-dihe-in -98.12, 116.43 APE8-rot-in 300.9 APE67-dihe-out -53.75, -27.12 -85.46, 67.62 APE12-dist-in 10.187 APE11-dist-in 9.285 APE10-dist-out 9.254 APE9-dist-out 12.122 None TPO185,SEP191,TPO208 TPO185,SEP191,TPO208 XRAY 2.09 0.192 0.219 A 302 285 5 0 0 3 [[36, 294]] 1.0 6hxf STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
6HXFB 24 314 968.0 R70:401 Type1 Inactive DFGin 7.036 14.719 BLAminus -131.41, 174.18 55.96, 79.92 -91.25, 25.51 284.11, 80.37 -64.33, -45.88 in-in in 8.201 Saltbr-in 2.627 HRD-in -68.06, -51.75 73.47, -2.03 in-out-out SNCioo out-out ActLoopNT-out 5.783 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -112.68, 149.83 APE9-dihe-na 72.86, -163.18 APE8-dihe-in -101.23, 115.87 APE8-rot-in 309.11 APE67-dihe-out -60.26, -25.07 -83.61, 68.28 APE12-dist-in 9.508 APE11-dist-in 8.645 APE10-dist-out 9.853 APE9-dist-out 12.044 None TPO185,SEP191,TPO208 TPO185,SEP191,TPO208 XRAY 2.09 0.192 0.219 B 302 291 0 0 0 0 [[36, 294]] 1.0 6hxf STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
6HXFD 23 312 968.0 R70:401 Type1 Inactive DFGin 6.841 14.592 BLAminus -132.32, 175.19 55.51, 78.82 -91.0, 24.61 284.33, 77.6 -63.59, -43.39 in-in in 8.095 Saltbr-in 2.567 HRD-in -67.7, -50.82 72.97, -1.8 in-out-out SNCioo out-out ActLoopNT-out 5.861 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -100.37, 144.45 APE9-dihe-na 65.33, -159.92 APE8-dihe-in -98.74, 116.85 APE8-rot-in 308.08 APE67-dihe-out -55.27, -26.35 -87.68, 68.83 APE12-dist-in 9.181 APE11-dist-in 8.783 APE10-dist-out 9.351 APE9-dist-out 12.09 None TPO185,SEP191,TPO208 TPO185,SEP191,TPO208 XRAY 2.09 0.192 0.219 D 302 287 3 0 0 0 [[36, 294]] 1.0 6hxf STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
7QGPA 23 313 968.0 DJ8:401 Type1.5_Front Inactive DFGin 6.63 15.647 BLBminus -137.41, 176.17 64.63, 46.3 -55.04, 138.14 280.95, 68.0 -53.28, 137.64 in-out in 8.416 Saltbr-out 10.651 HRD-in -69.38, -55.58 84.71, -10.94 out-out-out SNCooo out-out ActLoopNT-out 11.032 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -131.79, 8.52 APE9-dihe-na 91.31, 163.78 APE8-dihe-in -62.99, 130.71 APE8-rot-in 298.17 APE67-dihe-out -58.73, -25.46 -85.93, 65.94 APE12-dist-in 12.317 APE11-dist-in 13.564 APE10-dist-out 8.716 APE9-dist-out 11.288 None None None XRAY 1.9 0.201 0.237 A 302 288 3 0 0 0 [[36, 294]] 1.0 7qgp STE_STK10_HUMAN STE 4.6e-94 320.5 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
5AJQA 24 312 968.0 DB8:800 Type1 Inactive DFGin 6.259 15.744 None -120.59, 174.2 81.32, -56.36 57.24, 29.42 287.8, 79.18 102.53, -17.28 out-out out 10.748 Saltbr-out 10.947 HRD-in -68.33, -48.71 84.04, -21.17 out-out-out SNCooo out-out ActLoopNT-out 12.573 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -85.91, 130.23 APE9-dihe-na 91.1, 7.46 APE8-dihe-in -59.1, 130.74 APE8-rot-in 288.9 APE67-dihe-out -66.14, -20.66 -86.49, 69.24 APE12-dist-none 999.0 APE11-dist-out 18.692 APE10-dist-out 14.146 APE9-dist-out 10.682 None None None XRAY 2.2 0.219 0.257 A 295 280 9 0 0 6 [[36, 294]] 1.0 5ajq STE_STK10_HUMAN STE 1.9e-94 321.7 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
5AJQB 25 312 968.0 DB8:800 Type1 Inactive DFGin 6.286 15.939 None -120.49, 173.38 83.25, -57.95 53.22, 23.51 288.78, 77.4 -62.81, -49.77 out-none out 10.89 Saltbr-none 999.0 HRD-in -69.73, -48.6 82.63, -20.29 none-out-none SNCnon out-none ActLoopNT-out 6.673 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 83.37 APE8-rot-in 290.95 APE67-dihe-in -67.97, -24.14 -101.21, 28.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.219 0.257 B 295 267 21 0 0 13 [[36, 294]] 1.0 5ajq STE_STK10_HUMAN STE 1.9e-94 321.7 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
6GTTA 18 316 968.0 B96:60500 Type2 Inactive DFGout 14.357 11.25 BBAminus -122.71, -176.27 -164.19, 106.76 -94.52, 78.45 303.25, 45.24 -69.74, 999.0 in-in in 9.527 Saltbr-in 2.91 HRD-in -75.32, -62.48 89.24, -7.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -54.1 APE8-rot-in 307.29 APE67-dihe-out -65.46, -17.63 -89.59, 54.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.244 0.301 A 302 280 19 0 0 17 [[36, 294]] 1.0 6gtt STE_STK10_HUMAN STE 4.6e-94 320.5 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
6EIMA 26 317 968.0 B6E:405 Type2 Inactive DFGout 13.311 9.69 BBAminus -116.85, 166.04 -137.31, 80.27 -69.97, -39.66 277.09, 110.17 -91.42, 14.8 in-in in 8.219 Saltbr-in 2.787 HRD-in -95.89, -59.64 74.79, 2.61 in-out-out SNCioo out-out ActLoopNT-out 12.792 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -99.38, 131.17 APE9-dihe-na 128.7, 169.19 APE8-dihe-in -106.93, 126.69 APE8-rot-in 305.68 APE67-dihe-in -61.79, -26.5 -47.76, -46.99 APE12-dist-out 22.592 APE11-dist-out 23.54 APE10-dist-out 24.082 APE9-dist-out 26.025 None None None XRAY 1.43 0.155 0.174 A 302 286 6 0 0 0 [[36, 294]] 1.0 6eim STE_STK10_HUMAN STE 3e-93 317.8 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
6EIMB 23 317 968.0 B6E:402 Type2 Inactive DFGout 13.291 9.816 BBAminus -116.36, 168.22 -139.14, 76.85 -70.31, -37.77 277.47, 112.66 -103.6, 2.73 in-in in 7.995 Saltbr-in 2.717 HRD-in -97.94, -57.89 73.08, 9.78 in-out-out SNCioo out-out ActLoopNT-out 12.63 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -104.05, 130.3 APE9-dihe-na 136.47, 172.53 APE8-dihe-in -107.45, 127.14 APE8-rot-in 303.64 APE67-dihe-in -59.5, -26.27 -46.06, -49.12 APE12-dist-out 22.323 APE11-dist-out 23.822 APE10-dist-out 23.462 APE9-dist-out 25.984 None None None XRAY 1.43 0.155 0.174 B 302 295 0 0 0 0 [[36, 294]] 1.0 6eim STE_STK10_HUMAN STE 3e-93 317.8 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
4AOTA 18 314 968.0 GW8:61319 Type1 Inactive DFGout 14.321 10.263 None -81.46, 137.23 -62.75, -41.15 -135.71, 144.39 183.19, 71.41 -158.36, 166.86 out-out out 11.104 Saltbr-out 9.181 HRD-in -75.1, -50.54 72.66, 3.42 out-out-out SNCooo out-out ActLoopNT-out 20.134 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 89.4 APE8-dihe-in -72.74, 134.2 APE8-rot-in 305.44 APE67-dihe-out -67.28, -26.48 -88.67, 72.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.62 None None None XRAY 2.33 0.219 0.252 A 302 276 21 0 0 13 [[36, 294]] 1.0 4aot STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
4AOTB 18 314 968.0 GW8:61319 Type1 Inactive DFGout 14.925 11.462 None -79.03, 142.25 -66.19, -41.04 -134.87, 146.44 176.21, 70.39 -162.34, 170.06 out-out out 13.917 Saltbr-out 9.911 HRD-in -74.94, -50.25 74.37, 0.2 out-out-out SNCooo out-out ActLoopNT-out 20.137 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoo APE10-dihe-na 999.0, -177.9 APE9-dihe-na 79.39, 68.84 APE8-dihe-in -71.24, 121.3 APE8-rot-in 308.6 APE67-dihe-out -67.31, -26.76 -85.51, 69.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.326 APE9-dist-out 11.118 None None None XRAY 2.33 0.219 0.252 B 302 277 18 0 0 11 [[36, 294]] 1.0 4aot STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
4USDA 24 314 968.0 R09:500 Type1 Inactive DFGout 15.983 6.513 None -127.04, 147.35 -89.99, -48.64 52.66, 44.35 201.48, 52.81 133.39, -8.64 out-out out 11.474 Saltbr-out 7.219 HRD-in -98.1, -42.18 72.73, 6.06 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 14.27 APE8-dihe-in -75.81, 156.02 APE8-rot-in 326.25 APE67-dihe-out -84.4, -25.55 -131.98, 90.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.855 None None None XRAY 3.05 0.237 0.289 A 302 268 23 0 0 15 [[36, 294]] 1.0 4usd STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
4USDB 24 314 968.0 R09:500 Type1 Inactive DFGout 15.932 6.474 None -127.63, 146.51 -89.68, -49.09 53.05, 44.03 201.59, 52.69 133.19, -10.34 out-out out 11.485 Saltbr-out 7.256 HRD-in -95.04, -42.77 73.11, 4.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 15.7 APE8-dihe-in -74.23, 153.57 APE8-rot-in 331.06 APE67-dihe-out -82.52, -24.09 -130.17, 87.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.87 None None None XRAY 3.05 0.237 0.289 B 302 267 24 0 0 15 [[36, 294]] 1.0 4usd STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
4EQUA 24 317 968.0 G6I:401 Type2 Inactive DFGout 12.962 11.109 None -131.84, 176.0 -151.34, 132.05 -118.68, 177.7 313.7, 118.54 76.43, -131.58 in-in in 8.943 Saltbr-in 2.958 HRD-in -78.34, -55.56 69.93, 3.31 in-out-out SNCioo out-out ActLoopNT-out 6.838 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -6.77 APE9-dihe-na 121.61, 164.05 APE8-dihe-in -85.52, 135.62 APE8-rot-in 332.46 APE67-dihe-in -57.59, -32.28 -67.44, -34.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 24.554 APE9-dist-out 25.847 None None None XRAY 2.0 0.224 0.246 A 302 274 20 0 0 9 [[36, 294]] 1.0 4equ STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
4EQUB 24 317 968.0 G6I:401 Type2 Inactive DFGout 12.932 10.814 None -133.33, 178.11 -152.01, 130.99 -119.28, 176.3 314.12, 118.42 77.48, -131.5 in-in in 8.858 Saltbr-in 2.677 HRD-in -78.61, -56.75 72.94, 3.03 in-out-out SNCioo out-out ActLoopNT-out 6.8 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -81.28, 51.58 APE9-dihe-na 125.6, 166.52 APE8-dihe-in -85.58, 135.09 APE8-rot-in 333.22 APE67-dihe-in -58.76, -29.8 -67.43, -34.34 APE12-dist-none 999.0 APE11-dist-out 26.582 APE10-dist-out 23.744 APE9-dist-out 25.79 None None None XRAY 2.0 0.224 0.246 B 302 282 12 0 0 8 [[36, 294]] 1.0 4equ STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
6I2YA 24 317 968.0 88Z:2000 Type2 Inactive DFGout 14.256 8.574 None -142.6, 167.0 -107.59, -54.88 62.87, -46.4 275.81, 122.12 -90.27, -135.26 out-out out 10.946 Saltbr-out 9.656 HRD-in -100.04, -54.51 71.49, 1.4 out-in-out SNCoio in-out ActLoopNT-in 3.454 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -142.05 APE9-dihe-na -118.43, -179.23 APE8-dihe-in -77.25, 139.36 APE8-rot-in 315.91 APE67-dihe-in -58.76, -37.44 -65.9, -40.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.826 APE9-dist-out 27.363 None None None XRAY 2.56 0.264 0.283 A 302 279 15 0 0 10 [[36, 294]] 1.0 6i2y STE_STK10_HUMAN STE 4.6e-94 320.5 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
6I2YB 24 317 968.0 88Z:2000 Type2 Inactive DFGout 14.256 8.894 None -141.77, 169.33 -104.17, -54.09 61.03, 36.32 275.49, 122.46 -178.77, -139.27 out-none out 10.523 Saltbr-none 999.0 HRD-in -100.14, -55.33 72.94, 1.28 none-out-out SNCnoo out-out ActLoopNT-out 3.996 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 999.0 APE9-dihe-na -121.96, -178.86 APE8-dihe-in -77.3, 140.17 APE8-rot-none 999.0 APE67-dihe-in -63.08, -39.73 -66.89, -45.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.626 APE9-dist-out 26.545 None None None XRAY 2.56 0.264 0.283 B 302 277 17 0 0 10 [[36, 294]] 1.0 6i2y STE_STK10_HUMAN STE 4.6e-94 320.5 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
5OWQA 30 317 968.0 38O:600 Type1 Inactive None 999.0 999.0 None -110.03, 168.4 44.48, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 10.669 Saltbr-none 999.0 HRD-in -81.59, -60.25 72.43, 10.89 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -97.79, -7.31 999.0, 33.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.265 0.305 A 302 255 33 0 0 20 [[36, 294]] 1.0 5owq STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
5OWQB 32 317 968.0 38O:600 Type1 Inactive None 999.0 999.0 None -111.67, 174.73 56.37, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.674 Saltbr-out 5.294 HRD-in -80.32, -59.59 72.13, 11.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -98.8, -4.63 999.0, 29.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.265 0.305 B 302 254 32 0 0 20 [[36, 294]] 1.0 5owq STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10

STE_STK10 (Serine/threonine-protein kinase 10)

Total number of chains: 27
Active chains: 3
Family: STE
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 33.3% AF-O94804-K1A
DFGout None 8 29.6% 4EQUB
DFGout BBAminus 3 11.1% 6EIMB
DFGin ABAminus 2 7.4% 4USEA
DFGin None 2 7.4% 5AJQA
None None 2 7.4% 5OWQB
DFGin BLBminus 1 3.7% 7QGPA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STK10_HUMAN AF-O94804-K1A O94804 28 302 968.0 No_ligand No_ligand Active DFGin 6.452 14.249 BLAminus -135.71, 176.66 59.25, 66.38 -82.18, 11.09 287.41, 80.75 -59.47, -31.26 in-in in 8.534 Saltbr-in 2.824 HRD-in -71.19, -46.57 66.11, -8.52 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.89, 150.24 APE9-dihe-na 128.53, 173.67 APE8-dihe-in -80.96, 122.95 APE8-rot-in 304.51 APE67-dihe-in -72.34, -25.41 -48.31, -39.05 APE12-dist-in 9.025 APE11-dist-in 11.887 APE10-dist-in 6.129 APE9-dist-in 3.523 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[36, 294]] 1.0 AF-O94804-K1 Homo sapiens STE_STK10_HUMAN STE 1.4e-94 322.1 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN AF-O94804-K3A O94804 28 302 968.0 No_ligand No_ligand Active DFGin 6.224 14.62 BLAminus -134.36, -179.98 56.11, 76.53 -90.84, 11.03 290.99, 80.96 -61.5, -19.4 in-in in 9.137 Saltbr-in 2.877 HRD-in -72.98, -44.73 68.12, -11.2 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.55, 136.15 APE9-dihe-na 139.96, 175.77 APE8-dihe-in -84.43, 126.08 APE8-rot-in 304.38 APE67-dihe-in -70.91, -25.3 -51.73, -37.71 APE12-dist-in 9.345 APE11-dist-in 11.725 APE10-dist-in 5.888 APE9-dist-in 3.354 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[36, 294]] 1.0 AF-O94804-K3 Homo sapiens STE_STK10_HUMAN STE 1.4e-94 322.1 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 6HXFC O94804 24 312 968.0 R70:401 Type1 Active DFGin 6.939 14.636 BLAminus -133.33, 174.27 55.01, 80.49 -91.62, 24.2 286.74, 75.79 -63.56, -43.2 in-in in 8.248 Saltbr-in 2.397 HRD-in -71.95, -49.91 71.21, -0.58 in-in-in SNCiii in-in ActLoopNT-in 3.008 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.89, 153.47 APE9-dihe-na 116.81, -165.08 APE8-dihe-in -105.94, 128.94 APE8-rot-in 311.81 APE67-dihe-in -64.78, -27.93 -51.25, -38.45 APE12-dist-in 8.899 APE11-dist-in 11.561 APE10-dist-in 6.007 APE9-dist-in 3.572 None TPO185,SEP191,TPO208 TPO185,SEP191,TPO208 XRAY 2.09 0.192 0.219 C 302 288 1 0 0 0 [[36, 294]] 1.0 6hxf Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 4USEA O94804 24 316 968.0 R09:500 Type1 Inactive DFGin 6.667 16.312 ABAminus -124.06, -47.73 -111.47, 110.64 -107.37, 33.1 286.3, 80.35 -74.02, -29.24 in-out in 9.875 Saltbr-out 5.384 HRD-in -76.52, -50.26 63.76, 8.26 out-out-out SNCooo out-out ActLoopNT-out 5.88 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.21 APE8-rot-in 292.58 APE67-dihe-out -68.99, -19.32 -97.26, 50.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.226 0.251 A 302 286 7 0 0 7 [[36, 294]] 1.0 4use Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 4USEB O94804 24 316 968.0 R09:500 Type1 Inactive DFGin 6.672 16.394 ABAminus -123.54, -48.03 -110.84, 111.05 -107.61, 33.16 286.69, 80.16 -75.08, -28.62 in-out in 9.894 Saltbr-out 5.358 HRD-in -76.02, -50.04 64.2, 8.63 out-out-out SNCooo out-out ActLoopNT-out 5.889 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -53.4 APE8-rot-in 294.34 APE67-dihe-out -69.37, -18.81 -96.21, 50.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.226 0.251 B 302 278 15 0 0 6 [[36, 294]] 1.0 4use Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 4BC6A O94804 24 316 968.0 XZN:1317 Type1 Inactive DFGin 6.702 16.554 BLAminus -115.1, 176.1 50.46, 84.66 -96.24, 32.79 282.83, 79.72 -68.79, -52.65 in-out in 9.853 Saltbr-out 6.308 HRD-in -70.14, -48.74 64.67, 6.49 out-out-none SNCoon out-none ActLoopNT-out 5.794 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.41, -27.46 999.0, 17.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.214 0.254 A 293 285 8 0 0 8 [[36, 294]] 1.0 4bc6 Homo sapiens STE_STK10_HUMAN STE 1.8e-94 321.8 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 2J7TA O94804 25 317 968.0 274:1324 Type1 Inactive DFGin 6.693 16.261 BLAminus -130.09, 176.02 61.18, 79.65 -92.72, 22.97 287.66, 81.69 -62.25, -51.67 in-none in 9.552 Saltbr-none 999.0 HRD-in -71.07, -51.96 69.61, 2.63 none-out-out SNCnoo out-out ActLoopNT-out 5.787 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 999.0 APE9-dihe-na 130.26, -176.82 APE8-dihe-in -110.48, 131.85 APE8-rot-in 320.34 APE67-dihe-in -55.31, -32.25 -58.76, -42.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 21.531 APE9-dist-out 25.611 None None None XRAY 2.0 0.205 0.235 A 302 285 8 0 0 4 [[36, 294]] 1.0 2j7t Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 5OWRA O94804 23 317 968.0 1N1:401 Type1 Inactive DFGin 6.498 16.722 BLAminus -126.18, 173.2 57.39, 79.01 -91.46, 24.21 286.72, 77.35 -53.02, -57.95 out-out out 10.205 Saltbr-out 8.136 HRD-in -70.96, -54.03 67.34, 13.9 out-out-none SNCoon out-none ActLoopNT-out 5.833 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.94, -27.24 999.0, -15.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.221 0.254 A 302 282 13 0 0 7 [[36, 294]] 1.0 5owr Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 6HXFA O94804 24 313 968.0 R70:401 Type1 Inactive DFGin 6.852 14.805 BLAminus -130.96, 172.47 55.0, 81.54 -91.14, 24.47 285.61, 78.24 -62.74, -43.57 in-in in 8.131 Saltbr-in 2.679 HRD-in -69.16, -50.08 73.44, -2.15 in-out-out SNCioo out-out ActLoopNT-out 5.888 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -113.63, 135.13 APE9-dihe-na 71.67, -159.59 APE8-dihe-in -98.12, 116.43 APE8-rot-in 300.9 APE67-dihe-out -53.75, -27.12 -85.46, 67.62 APE12-dist-in 10.187 APE11-dist-in 9.285 APE10-dist-out 9.254 APE9-dist-out 12.122 None TPO185,SEP191,TPO208 TPO185,SEP191,TPO208 XRAY 2.09 0.192 0.219 A 302 285 5 0 0 3 [[36, 294]] 1.0 6hxf Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 6HXFB O94804 24 314 968.0 R70:401 Type1 Inactive DFGin 7.036 14.719 BLAminus -131.41, 174.18 55.96, 79.92 -91.25, 25.51 284.11, 80.37 -64.33, -45.88 in-in in 8.201 Saltbr-in 2.627 HRD-in -68.06, -51.75 73.47, -2.03 in-out-out SNCioo out-out ActLoopNT-out 5.783 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -112.68, 149.83 APE9-dihe-na 72.86, -163.18 APE8-dihe-in -101.23, 115.87 APE8-rot-in 309.11 APE67-dihe-out -60.26, -25.07 -83.61, 68.28 APE12-dist-in 9.508 APE11-dist-in 8.645 APE10-dist-out 9.853 APE9-dist-out 12.044 None TPO185,SEP191,TPO208 TPO185,SEP191,TPO208 XRAY 2.09 0.192 0.219 B 302 291 0 0 0 0 [[36, 294]] 1.0 6hxf Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 6HXFD O94804 23 312 968.0 R70:401 Type1 Inactive DFGin 6.841 14.592 BLAminus -132.32, 175.19 55.51, 78.82 -91.0, 24.61 284.33, 77.6 -63.59, -43.39 in-in in 8.095 Saltbr-in 2.567 HRD-in -67.7, -50.82 72.97, -1.8 in-out-out SNCioo out-out ActLoopNT-out 5.861 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -100.37, 144.45 APE9-dihe-na 65.33, -159.92 APE8-dihe-in -98.74, 116.85 APE8-rot-in 308.08 APE67-dihe-out -55.27, -26.35 -87.68, 68.83 APE12-dist-in 9.181 APE11-dist-in 8.783 APE10-dist-out 9.351 APE9-dist-out 12.09 None TPO185,SEP191,TPO208 TPO185,SEP191,TPO208 XRAY 2.09 0.192 0.219 D 302 287 3 0 0 0 [[36, 294]] 1.0 6hxf Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 7QGPA O94804 23 313 968.0 DJ8:401 Type1.5_Front Inactive DFGin 6.63 15.647 BLBminus -137.41, 176.17 64.63, 46.3 -55.04, 138.14 280.95, 68.0 -53.28, 137.64 in-out in 8.416 Saltbr-out 10.651 HRD-in -69.38, -55.58 84.71, -10.94 out-out-out SNCooo out-out ActLoopNT-out 11.032 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -131.79, 8.52 APE9-dihe-na 91.31, 163.78 APE8-dihe-in -62.99, 130.71 APE8-rot-in 298.17 APE67-dihe-out -58.73, -25.46 -85.93, 65.94 APE12-dist-in 12.317 APE11-dist-in 13.564 APE10-dist-out 8.716 APE9-dist-out 11.288 None None None XRAY 1.9 0.201 0.237 A 302 288 3 0 0 0 [[36, 294]] 1.0 7qgp Homo sapiens STE_STK10_HUMAN STE 4.6e-94 320.5 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 5AJQA O94804 24 312 968.0 DB8:800 Type1 Inactive DFGin 6.259 15.744 None -120.59, 174.2 81.32, -56.36 57.24, 29.42 287.8, 79.18 102.53, -17.28 out-out out 10.748 Saltbr-out 10.947 HRD-in -68.33, -48.71 84.04, -21.17 out-out-out SNCooo out-out ActLoopNT-out 12.573 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -85.91, 130.23 APE9-dihe-na 91.1, 7.46 APE8-dihe-in -59.1, 130.74 APE8-rot-in 288.9 APE67-dihe-out -66.14, -20.66 -86.49, 69.24 APE12-dist-none 999.0 APE11-dist-out 18.692 APE10-dist-out 14.146 APE9-dist-out 10.682 None None None XRAY 2.2 0.219 0.257 A 295 280 9 0 0 6 [[36, 294]] 1.0 5ajq Homo sapiens STE_STK10_HUMAN STE 1.9e-94 321.7 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 5AJQB O94804 25 312 968.0 DB8:800 Type1 Inactive DFGin 6.286 15.939 None -120.49, 173.38 83.25, -57.95 53.22, 23.51 288.78, 77.4 -62.81, -49.77 out-none out 10.89 Saltbr-none 999.0 HRD-in -69.73, -48.6 82.63, -20.29 none-out-none SNCnon out-none ActLoopNT-out 6.673 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 83.37 APE8-rot-in 290.95 APE67-dihe-in -67.97, -24.14 -101.21, 28.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.219 0.257 B 295 267 21 0 0 13 [[36, 294]] 1.0 5ajq Homo sapiens STE_STK10_HUMAN STE 1.9e-94 321.7 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 6GTTA O94804 18 316 968.0 B96:60500 Type2 Inactive DFGout 14.357 11.25 BBAminus -122.71, -176.27 -164.19, 106.76 -94.52, 78.45 303.25, 45.24 -69.74, 999.0 in-in in 9.527 Saltbr-in 2.91 HRD-in -75.32, -62.48 89.24, -7.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -54.1 APE8-rot-in 307.29 APE67-dihe-out -65.46, -17.63 -89.59, 54.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.244 0.301 A 302 280 19 0 0 17 [[36, 294]] 1.0 6gtt Homo sapiens STE_STK10_HUMAN STE 4.6e-94 320.5 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 6EIMA O94804 26 317 968.0 B6E:405 Type2 Inactive DFGout 13.311 9.69 BBAminus -116.85, 166.04 -137.31, 80.27 -69.97, -39.66 277.09, 110.17 -91.42, 14.8 in-in in 8.219 Saltbr-in 2.787 HRD-in -95.89, -59.64 74.79, 2.61 in-out-out SNCioo out-out ActLoopNT-out 12.792 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -99.38, 131.17 APE9-dihe-na 128.7, 169.19 APE8-dihe-in -106.93, 126.69 APE8-rot-in 305.68 APE67-dihe-in -61.79, -26.5 -47.76, -46.99 APE12-dist-out 22.592 APE11-dist-out 23.54 APE10-dist-out 24.082 APE9-dist-out 26.025 None None None XRAY 1.43 0.155 0.174 A 302 286 6 0 0 0 [[36, 294]] 1.0 6eim Homo sapiens STE_STK10_HUMAN STE 3e-93 317.8 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 6EIMB O94804 23 317 968.0 B6E:402 Type2 Inactive DFGout 13.291 9.816 BBAminus -116.36, 168.22 -139.14, 76.85 -70.31, -37.77 277.47, 112.66 -103.6, 2.73 in-in in 7.995 Saltbr-in 2.717 HRD-in -97.94, -57.89 73.08, 9.78 in-out-out SNCioo out-out ActLoopNT-out 12.63 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -104.05, 130.3 APE9-dihe-na 136.47, 172.53 APE8-dihe-in -107.45, 127.14 APE8-rot-in 303.64 APE67-dihe-in -59.5, -26.27 -46.06, -49.12 APE12-dist-out 22.323 APE11-dist-out 23.822 APE10-dist-out 23.462 APE9-dist-out 25.984 None None None XRAY 1.43 0.155 0.174 B 302 295 0 0 0 0 [[36, 294]] 1.0 6eim Homo sapiens STE_STK10_HUMAN STE 3e-93 317.8 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 4AOTA O94804 18 314 968.0 GW8:61319 Type1 Inactive DFGout 14.321 10.263 None -81.46, 137.23 -62.75, -41.15 -135.71, 144.39 183.19, 71.41 -158.36, 166.86 out-out out 11.104 Saltbr-out 9.181 HRD-in -75.1, -50.54 72.66, 3.42 out-out-out SNCooo out-out ActLoopNT-out 20.134 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 89.4 APE8-dihe-in -72.74, 134.2 APE8-rot-in 305.44 APE67-dihe-out -67.28, -26.48 -88.67, 72.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.62 None None None XRAY 2.33 0.219 0.252 A 302 276 21 0 0 13 [[36, 294]] 1.0 4aot Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 4AOTB O94804 18 314 968.0 GW8:61319 Type1 Inactive DFGout 14.925 11.462 None -79.03, 142.25 -66.19, -41.04 -134.87, 146.44 176.21, 70.39 -162.34, 170.06 out-out out 13.917 Saltbr-out 9.911 HRD-in -74.94, -50.25 74.37, 0.2 out-out-out SNCooo out-out ActLoopNT-out 20.137 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoo APE10-dihe-na 999.0, -177.9 APE9-dihe-na 79.39, 68.84 APE8-dihe-in -71.24, 121.3 APE8-rot-in 308.6 APE67-dihe-out -67.31, -26.76 -85.51, 69.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.326 APE9-dist-out 11.118 None None None XRAY 2.33 0.219 0.252 B 302 277 18 0 0 11 [[36, 294]] 1.0 4aot Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 4USDA O94804 24 314 968.0 R09:500 Type1 Inactive DFGout 15.983 6.513 None -127.04, 147.35 -89.99, -48.64 52.66, 44.35 201.48, 52.81 133.39, -8.64 out-out out 11.474 Saltbr-out 7.219 HRD-in -98.1, -42.18 72.73, 6.06 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 14.27 APE8-dihe-in -75.81, 156.02 APE8-rot-in 326.25 APE67-dihe-out -84.4, -25.55 -131.98, 90.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.855 None None None XRAY 3.05 0.237 0.289 A 302 268 23 0 0 15 [[36, 294]] 1.0 4usd Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 4USDB O94804 24 314 968.0 R09:500 Type1 Inactive DFGout 15.932 6.474 None -127.63, 146.51 -89.68, -49.09 53.05, 44.03 201.59, 52.69 133.19, -10.34 out-out out 11.485 Saltbr-out 7.256 HRD-in -95.04, -42.77 73.11, 4.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 15.7 APE8-dihe-in -74.23, 153.57 APE8-rot-in 331.06 APE67-dihe-out -82.52, -24.09 -130.17, 87.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.87 None None None XRAY 3.05 0.237 0.289 B 302 267 24 0 0 15 [[36, 294]] 1.0 4usd Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 4EQUA O94804 24 317 968.0 G6I:401 Type2 Inactive DFGout 12.962 11.109 None -131.84, 176.0 -151.34, 132.05 -118.68, 177.7 313.7, 118.54 76.43, -131.58 in-in in 8.943 Saltbr-in 2.958 HRD-in -78.34, -55.56 69.93, 3.31 in-out-out SNCioo out-out ActLoopNT-out 6.838 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -6.77 APE9-dihe-na 121.61, 164.05 APE8-dihe-in -85.52, 135.62 APE8-rot-in 332.46 APE67-dihe-in -57.59, -32.28 -67.44, -34.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 24.554 APE9-dist-out 25.847 None None None XRAY 2.0 0.224 0.246 A 302 274 20 0 0 9 [[36, 294]] 1.0 4equ Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 4EQUB O94804 24 317 968.0 G6I:401 Type2 Inactive DFGout 12.932 10.814 None -133.33, 178.11 -152.01, 130.99 -119.28, 176.3 314.12, 118.42 77.48, -131.5 in-in in 8.858 Saltbr-in 2.677 HRD-in -78.61, -56.75 72.94, 3.03 in-out-out SNCioo out-out ActLoopNT-out 6.8 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -81.28, 51.58 APE9-dihe-na 125.6, 166.52 APE8-dihe-in -85.58, 135.09 APE8-rot-in 333.22 APE67-dihe-in -58.76, -29.8 -67.43, -34.34 APE12-dist-none 999.0 APE11-dist-out 26.582 APE10-dist-out 23.744 APE9-dist-out 25.79 None None None XRAY 2.0 0.224 0.246 B 302 282 12 0 0 8 [[36, 294]] 1.0 4equ Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 6I2YA O94804 24 317 968.0 88Z:2000 Type2 Inactive DFGout 14.256 8.574 None -142.6, 167.0 -107.59, -54.88 62.87, -46.4 275.81, 122.12 -90.27, -135.26 out-out out 10.946 Saltbr-out 9.656 HRD-in -100.04, -54.51 71.49, 1.4 out-in-out SNCoio in-out ActLoopNT-in 3.454 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -142.05 APE9-dihe-na -118.43, -179.23 APE8-dihe-in -77.25, 139.36 APE8-rot-in 315.91 APE67-dihe-in -58.76, -37.44 -65.9, -40.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.826 APE9-dist-out 27.363 None None None XRAY 2.56 0.264 0.283 A 302 279 15 0 0 10 [[36, 294]] 1.0 6i2y Homo sapiens STE_STK10_HUMAN STE 4.6e-94 320.5 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 6I2YB O94804 24 317 968.0 88Z:2000 Type2 Inactive DFGout 14.256 8.894 None -141.77, 169.33 -104.17, -54.09 61.03, 36.32 275.49, 122.46 -178.77, -139.27 out-none out 10.523 Saltbr-none 999.0 HRD-in -100.14, -55.33 72.94, 1.28 none-out-out SNCnoo out-out ActLoopNT-out 3.996 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 999.0 APE9-dihe-na -121.96, -178.86 APE8-dihe-in -77.3, 140.17 APE8-rot-none 999.0 APE67-dihe-in -63.08, -39.73 -66.89, -45.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.626 APE9-dist-out 26.545 None None None XRAY 2.56 0.264 0.283 B 302 277 17 0 0 10 [[36, 294]] 1.0 6i2y Homo sapiens STE_STK10_HUMAN STE 4.6e-94 320.5 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 5OWQA O94804 30 317 968.0 38O:600 Type1 Inactive None 999.0 999.0 None -110.03, 168.4 44.48, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 10.669 Saltbr-none 999.0 HRD-in -81.59, -60.25 72.43, 10.89 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -97.79, -7.31 999.0, 33.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.265 0.305 A 302 255 33 0 0 20 [[36, 294]] 1.0 5owq Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STK10_HUMAN 5OWQB O94804 32 317 968.0 38O:600 Type1 Inactive None 999.0 999.0 None -111.67, 174.73 56.37, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.674 Saltbr-out 5.294 HRD-in -80.32, -59.59 72.13, 11.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -98.8, -4.63 999.0, 29.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.265 0.305 B 302 254 32 0 0 20 [[36, 294]] 1.0 5owq Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10

STE_STK10 (Serine/threonine-protein kinase 10)

Total number of chains: 0
Active chains: 0
Family: STE
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name