TKL_RIPK2 (Receptor-interacting serine/threonine-protein kinase 2)

Total number of chains: 72
Active chains: 1
Family: TKL
Uniprot: RIPK2_HUMAN
Kinase Domain Residues: 18 - 292
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 47 65.3% AF-O43353-K3A
DFGin BLBplus 10 13.9% 5NG3A
DFGin None 6 8.3% 6FU5B
DFGin BLBminus 3 4.2% 6S1FA
DFGout BBAminus 3 4.2% 6ES0A
DFGout None 3 4.2% 5AR7A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-O43353-K3A 10 300 540.0 No_ligand No_ligand Active DFGin 5.835 13.916 BLAminus -131.05, 176.49 59.07, 72.73 -86.61, 15.53 288.91, 79.18 -58.82, -34.9 in-in in 8.072 Saltbr-in 2.745 HRD-in -79.76, -41.87 62.78, -13.47 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -60.31, 147.35 APE9-dihe-na 163.97, 163.66 APE8-dihe-in -80.92, 119.55 APE8-rot-in 303.11 APE67-dihe-in -58.79, -31.16 -43.37, -46.06 APE12-dist-in 12.152 APE11-dist-in 8.69 APE10-dist-in 6.386 APE9-dist-in 3.816 None None None AF2 -1.0 1.0 1.0 A 291 291 0 0 0 0 [[18, 292]] 1.0 AF-O43353-K3 TKL_RIPK2_HUMAN TKL 3.5e-73 252.3 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5NG0A 6 300 540.0 ACP:1000 ATPlike Inactive DFGin 5.878 14.178 BLAminus -123.27, -179.27 62.78, 77.58 -93.4, 20.77 286.94, 75.81 -61.85, -28.6 in-in in 8.205 Saltbr-in 2.745 HRD-in -73.28, -52.62 66.02, 10.49 in-in-out SNCiio in-out ActLoopNT-in 2.847 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.46 APE8-dihe-in -72.18, 143.02 APE8-rot-out 185.7 APE67-dihe-in -65.61, -24.81 -104.28, 1.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8 L294F None None XRAY 2.0 0.171 0.191 A 304 274 21 0 0 15 [[18, 292]] 1.0 5ng0 TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5NG0B 5 299 540.0 ACP:401 ATPlike Inactive DFGin 5.887 14.177 BLAminus -123.03, -178.96 62.29, 77.78 -94.31, 21.44 286.41, 77.58 -63.12, -27.82 in-in in 8.16 Saltbr-in 2.756 HRD-in -74.08, -51.77 69.59, 3.54 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -72.33, -175.56 APE9-dihe-na 154.16, -172.85 APE8-dihe-in -105.14, 130.27 APE8-rot-in 300.55 APE67-dihe-in -61.64, -28.91 -51.09, -46.77 APE12-dist-in 11.85 APE11-dist-out 7.402 APE10-dist-in 6.02 APE9-dist-in 3.342 L294F None None XRAY 2.0 0.171 0.191 B 304 282 13 0 0 10 [[18, 292]] 1.0 5ng0 TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5AR3A 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.924 14.288 BLAminus -133.03, 175.56 72.21, 76.24 -97.68, 34.32 293.9, 86.68 -66.76, -37.47 in-in in 7.994 Saltbr-in 2.8 HRD-in -61.0, -40.82 51.84, 8.75 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -117.65 APE9-dihe-na 164.28, -57.84 APE8-dihe-in -114.77, 107.38 APE8-rot-out 185.6 APE67-dihe-in -64.24, -32.65 -95.4, 6.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.709 APE9-dist-out 10.828 None None None XRAY 3.23 0.192 0.254 A 326 279 26 0 0 14 [[18, 292]] 1.0 5ar3 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5AR3B 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.87 14.418 BLAminus -128.31, 176.09 65.92, 78.1 -98.91, 35.33 294.64, 70.55 -68.55, -48.71 in-in in 8.021 Saltbr-in 2.88 HRD-in -65.19, -46.65 55.58, 8.54 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.98 APE8-rot-out 49.06 APE67-dihe-in -39.82, -41.25 -97.08, -7.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.23 0.192 0.254 B 326 276 29 0 0 16 [[18, 292]] 1.0 5ar3 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
AF-O43353-K1A 10 300 540.0 No_ligand No_ligand Inactive DFGin 5.846 14.008 BLAminus -127.94, 175.85 61.05, 79.69 -94.57, 16.88 285.86, 79.13 -59.24, -35.38 in-in in 8.056 Saltbr-in 2.729 HRD-in -78.75, -47.93 64.43, -6.6 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -61.43, 170.33 APE9-dihe-na 162.37, 176.49 APE8-dihe-in -85.18, 118.94 APE8-rot-in 304.26 APE67-dihe-in -60.83, -35.85 -43.4, -45.78 APE12-dist-in 11.866 APE11-dist-out 7.591 APE10-dist-in 6.511 APE9-dist-in 3.494 None None None AF2 -1.0 1.0 1.0 A 291 291 0 0 0 0 [[18, 292]] 1.0 AF-O43353-K1 TKL_RIPK2_HUMAN TKL 3.5e-73 252.3 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
8AZAA 8 314 540.0 No_ligand No_ligand Inactive DFGin 6.638 14.972 BLAminus -149.95, -164.59 59.67, 64.47 -87.13, 14.1 289.04, 7.53 -62.24, -46.57 in-out in 9.738 Saltbr-out 8.893 HRD-in -64.59, -39.64 71.24, -10.99 out-in-out SNCoio in-out ActLoopNT-in 3.246 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.84 APE8-rot-out 77.29 APE67-dihe-in -86.62, -6.01 -67.77, -11.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.15 999.0 999.0 A 317 284 23 0 0 13 [[18, 292]] 1.0 8aza TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
8AZAB 8 314 540.0 No_ligand No_ligand Inactive DFGin 5.335 13.551 BLAminus -130.42, -164.95 50.89, 68.36 -81.01, 15.64 291.47, 76.47 -59.33, -43.28 in-out in 7.362 Saltbr-out 5.606 HRD-in -91.72, -62.3 59.19, 5.81 out-in-none SNCoin in-none ActLoopNT-in 3.461 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.15 999.0 999.0 B 317 246 61 0 0 25 [[18, 292]] 1.0 8aza TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5AR2A 4 310 540.0 No_ligand No_ligand Inactive DFGin 5.931 14.52 BLAminus -127.38, -176.39 62.31, 78.66 -95.92, 24.69 288.34, 80.55 -59.09, -44.11 in-in in 8.492 Saltbr-in 2.871 HRD-in -75.18, -53.25 68.8, 7.8 in-in-out SNCiio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 116.83 APE9-dihe-na -174.85, -153.32 APE8-dihe-in -65.24, 140.18 APE8-rot-out 190.57 APE67-dihe-in -65.15, -22.55 -115.33, 6.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.385 APE9-dist-out 10.606 None None None XRAY 2.44 0.172 0.211 A 326 277 30 0 0 14 [[18, 292]] 1.0 5ar2 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5AR2B 4 310 540.0 No_ligand No_ligand Inactive DFGin 6.051 14.522 BLAminus -121.7, 177.66 61.53, 80.64 -98.26, 20.96 286.82, 74.03 -54.66, -35.04 in-in in 8.435 Saltbr-in 3.479 HRD-in -73.03, -54.01 65.44, 6.7 in-in-out SNCiio in-out ActLoopNT-in 2.862 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -62.83, 130.3 APE9-dihe-na -160.33, 164.95 APE8-dihe-in -67.1, 149.78 APE8-rot-out 186.39 APE67-dihe-in -54.03, -24.23 -110.46, -3.23 APE12-dist-in 11.972 APE11-dist-in 9.991 APE10-dist-out 13.044 APE9-dist-out 10.63 None None None XRAY 2.44 0.172 0.211 B 326 285 22 0 0 11 [[18, 292]] 1.0 5ar2 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OA 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.136 13.906 BLAminus -125.19, -174.64 59.09, 81.1 -106.86, 24.62 291.19, 85.74 -72.37, -32.43 in-none in 7.781 Saltbr-none 999.0 HRD-in -58.73, -48.93 54.24, 22.59 none-in-out SNCnio in-out ActLoopNT-in 2.779 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 52.01 APE8-dihe-in -88.74, 126.44 APE8-rot-out 182.28 APE67-dihe-in -69.67, -13.84 -102.91, 3.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.78 None None None XRAY 2.89 0.219 0.252 A 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OB 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.075 13.855 BLAminus -124.69, -174.05 60.01, 82.18 -107.5, 25.35 291.09, 85.35 -69.3, -34.49 in-none in 7.852 Saltbr-none 999.0 HRD-in -59.53, -49.22 54.97, 22.29 none-in-out SNCnio in-out ActLoopNT-in 2.796 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.07 APE8-dihe-in -82.18, 127.67 APE8-rot-out 181.47 APE67-dihe-in -70.21, -14.17 -102.49, 4.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.789 None None None XRAY 2.89 0.219 0.252 B 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OC 5 310 540.0 9XA:401 Type1 Inactive DFGin 5.941 13.85 BLAminus -124.15, -173.26 59.49, 81.39 -107.32, 24.78 291.29, 84.01 -68.0, -35.39 in-none in 7.888 Saltbr-none 999.0 HRD-in -61.12, -47.92 53.98, 21.23 none-in-out SNCnio in-out ActLoopNT-in 2.789 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 58.39 APE8-dihe-in -87.67, 127.44 APE8-rot-out 182.78 APE67-dihe-in -69.34, -14.96 -102.25, 3.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.435 None None None XRAY 2.89 0.219 0.252 C 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OD 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1 13.76 BLAminus -124.11, -174.9 59.11, 83.61 -107.83, 24.21 291.26, 84.74 -71.93, -33.31 in-none in 7.712 Saltbr-none 999.0 HRD-in -58.77, -50.37 55.05, 21.57 none-in-out SNCnio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 52.34 APE8-dihe-in -81.49, 128.95 APE8-rot-out 42.92 APE67-dihe-in -70.09, -15.04 -103.55, 3.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.655 None None None XRAY 2.89 0.219 0.252 D 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OE 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.155 13.914 BLAminus -125.32, -175.39 59.04, 81.44 -106.24, 24.21 291.63, 86.05 -73.47, -30.79 in-in in 7.842 Saltbr-in 2.771 HRD-in -59.5, -48.44 53.52, 22.49 in-in-out SNCiio in-out ActLoopNT-in 2.77 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 63.28 APE8-dihe-in -87.25, 127.57 APE8-rot-out 182.11 APE67-dihe-in -69.71, -14.84 -102.46, 3.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.922 None None None XRAY 2.89 0.219 0.252 E 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OF 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.102 13.784 BLAminus -125.28, -174.81 60.87, 81.57 -107.6, 24.8 291.53, 85.38 -69.89, -33.64 in-none in 7.782 Saltbr-none 999.0 HRD-in -59.66, -48.54 55.22, 21.96 none-in-out SNCnio in-out ActLoopNT-in 2.792 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 60.19 APE8-dihe-in -79.96, 131.01 APE8-rot-out 181.63 APE67-dihe-in -71.08, -14.3 -102.18, 4.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.65 None None None XRAY 2.89 0.219 0.252 F 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OG 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.086 13.845 BLAminus -124.86, -174.91 60.12, 81.59 -107.81, 23.84 291.29, 84.93 -68.89, -36.67 in-none in 7.734 Saltbr-none 999.0 HRD-in -64.82, -49.86 54.77, 20.73 none-in-out SNCnio in-out ActLoopNT-in 2.787 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 60.09 APE8-dihe-in -78.03, 125.79 APE8-rot-out 184.52 APE67-dihe-in -69.81, -14.62 -102.95, 4.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.785 None None None XRAY 2.89 0.219 0.252 G 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OH 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.089 13.938 BLAminus -123.39, -173.38 58.61, 81.33 -105.97, 24.15 291.79, 83.79 -68.5, -35.98 in-in in 7.899 Saltbr-in 2.704 HRD-in -60.4, -48.42 54.87, 21.93 in-in-out SNCiio in-out ActLoopNT-in 2.787 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -55.03 APE8-dihe-in -80.95, 128.93 APE8-rot-out 42.89 APE67-dihe-in -69.91, -14.59 -102.1, 3.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.427 None None None XRAY 2.89 0.219 0.252 H 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OI 5 310 540.0 9XA:401 Type1 Inactive DFGin 5.946 13.887 BLAminus -123.53, -172.96 57.44, 81.36 -106.55, 24.49 290.99, 84.39 -68.01, -35.42 in-none in 7.844 Saltbr-none 999.0 HRD-in -60.65, -52.84 62.49, 6.67 none-in-out SNCnio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -155.66 APE8-dihe-in -115.79, 147.83 APE8-rot-out 226.21 APE67-dihe-in -65.02, -15.65 -101.34, 1.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.417 None None None XRAY 2.89 0.219 0.252 I 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OJ 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.126 13.853 BLAminus -125.49, -173.66 60.26, 80.69 -107.0, 24.2 291.57, 84.27 -70.16, -35.59 in-in in 7.787 Saltbr-in 2.761 HRD-in -59.56, -49.0 54.34, 21.8 in-in-out SNCiio in-out ActLoopNT-in 2.809 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 62.31 APE8-dihe-in -78.64, 127.4 APE8-rot-out 183.39 APE67-dihe-in -70.3, -14.88 -101.54, 2.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.595 None None None XRAY 2.89 0.219 0.252 J 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OK 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.129 13.806 BLAminus -123.47, -174.04 59.2, 82.79 -107.55, 23.57 291.68, 84.11 -72.29, -31.81 in-in in 7.777 Saltbr-in 2.823 HRD-in -59.03, -50.17 55.62, 20.99 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 54.61 APE8-dihe-in -86.36, 126.77 APE8-rot-out 185.25 APE67-dihe-in -70.21, -14.67 -104.03, 4.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.933 None None None XRAY 2.89 0.219 0.252 K 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OL 5 310 540.0 9XA:401 Type1 Inactive DFGin 5.977 13.872 BLAminus -123.97, -173.69 59.22, 81.96 -107.43, 24.71 291.89, 82.85 -67.15, -36.07 in-in in 7.91 Saltbr-in 2.745 HRD-in -60.31, -48.17 54.61, 21.38 in-in-out SNCiio in-out ActLoopNT-in 2.792 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 61.72 APE8-dihe-in -85.16, 131.31 APE8-rot-out 40.96 APE67-dihe-in -60.1, -15.62 -98.81, -9.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.391 None None None XRAY 2.89 0.219 0.252 L 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OM 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.106 13.875 BLAminus -124.12, -175.41 59.62, 81.55 -107.4, 24.65 291.81, 83.79 -71.72, -32.48 in-none in 7.797 Saltbr-none 999.0 HRD-in -58.16, -49.42 54.05, 21.71 none-in-out SNCnio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 41.26 APE8-dihe-in -78.53, 134.02 APE8-rot-out 36.01 APE67-dihe-in -69.76, -14.56 -101.27, 4.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.06 None None None XRAY 2.89 0.219 0.252 M 310 276 30 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5ON 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.079 13.928 BLAminus -124.88, -172.7 59.14, 81.77 -106.98, 23.8 291.97, 82.42 -69.42, -34.18 in-none in 7.947 Saltbr-none 999.0 HRD-in -59.84, -48.61 54.69, 21.04 none-in-out SNCnio in-out ActLoopNT-in 2.788 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 57.95 APE8-dihe-in -84.02, 128.93 APE8-rot-out 182.08 APE67-dihe-in -69.96, -13.84 -103.42, 3.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.652 None None None XRAY 2.89 0.219 0.252 N 310 272 34 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OO 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.184 13.824 BLAminus -123.94, -174.15 58.85, 81.43 -106.41, 23.33 291.99, 84.7 -71.56, -32.06 in-in in 7.791 Saltbr-in 2.791 HRD-in -58.13, -49.83 54.51, 21.43 in-in-out SNCiio in-out ActLoopNT-in 2.787 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 64.54 APE8-dihe-in -77.78, 132.07 APE8-rot-out 38.52 APE67-dihe-in -70.42, -14.07 -103.31, 4.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.389 None None None XRAY 2.89 0.219 0.252 O 310 276 30 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5OP 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.024 13.832 BLAminus -124.74, -174.78 59.93, 81.7 -106.98, 23.2 291.86, 82.87 -68.58, -34.35 in-none in 7.985 Saltbr-none 999.0 HRD-in -60.06, -48.48 54.27, 16.98 none-in-out SNCnio in-out ActLoopNT-in 2.792 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 52.76 APE8-dihe-in -83.36, 127.8 APE8-rot-out 182.51 APE67-dihe-in -70.3, -14.79 -101.64, 2.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.744 None None None XRAY 2.89 0.219 0.252 P 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6HMXA 5 310 540.0 GEZ:401 Type1 Inactive DFGin 6.236 14.316 BLAminus -124.52, -177.56 66.8, 84.95 -109.14, 29.79 295.83, 94.07 -68.94, -45.49 in-in in 7.794 Saltbr-in 3.234 HRD-in -58.38, -60.47 64.01, 17.43 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -151.32 APE9-dihe-na -124.57, -125.51 APE8-dihe-in -82.66, 129.77 APE8-rot-out 187.19 APE67-dihe-in -64.93, -22.0 -95.67, -1.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.556 APE9-dist-out 10.447 None None None XRAY 2.53 0.166 0.192 A 311 280 26 0 0 15 [[18, 292]] 1.0 6hmx TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6HMXB 5 310 540.0 GEZ:401 Type1 Inactive DFGin 6.186 14.368 BLAminus -124.43, -176.46 65.93, 86.3 -112.37, 30.95 293.81, 90.5 -69.1, -47.31 in-in in 7.919 Saltbr-in 3.156 HRD-in -59.3, -60.67 66.8, 11.61 in-in-out SNCiio in-out ActLoopNT-in 2.813 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 165.56 APE9-dihe-na -122.56, -147.83 APE8-dihe-in -59.45, 144.61 APE8-rot-out 192.64 APE67-dihe-in -62.6, -17.14 -111.83, -1.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.655 APE9-dist-out 11.168 None None None XRAY 2.53 0.166 0.192 B 311 282 24 0 0 14 [[18, 292]] 1.0 6hmx TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6SZEB 5 310 540.0 M2B:402 Type1 Inactive DFGin 6.039 14.574 BLAminus -129.09, 175.84 70.06, 89.61 -113.49, 18.44 288.29, 86.33 -60.8, -47.17 in-in in 7.885 Saltbr-in 3.128 HRD-in -75.74, -46.99 56.85, -2.91 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -136.96, -159.87 APE9-dihe-na -128.34, -119.13 APE8-dihe-in -65.42, 150.34 APE8-rot-out 193.04 APE67-dihe-in -52.67, -15.51 -114.53, -21.66 APE12-dist-none 999.0 APE11-dist-in 12.84 APE10-dist-out 10.121 APE9-dist-out 11.041 None None None XRAY 2.94 0.179 0.234 B 311 276 30 0 0 15 [[18, 292]] 1.0 6sze TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6SZJB 5 310 540.0 M5W:402 Type1 Inactive DFGin 6.06 14.803 BLAminus -127.62, -178.38 64.51, 85.71 -108.62, 30.49 299.07, 85.51 -62.99, -29.31 in-in in 8.036 Saltbr-in 2.624 HRD-in -73.84, -57.47 64.38, 3.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -111.13, -160.71 APE9-dihe-na -124.86, -125.22 APE8-dihe-in -69.02, 143.41 APE8-rot-out 187.62 APE67-dihe-in -53.68, -19.89 -104.22, -17.47 APE12-dist-none 999.0 APE11-dist-in 13.747 APE10-dist-out 10.385 APE9-dist-out 10.979 None None None XRAY 2.53 0.191 0.241 B 311 283 23 0 0 17 [[18, 292]] 1.0 6szj TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6FU5A 5 315 540.0 E7N:400 Type1 Inactive DFGin 5.97 14.129 BLAminus -149.81, 168.35 73.17, 56.82 -87.36, -24.33 315.9, 145.59 -100.37, 169.03 in-in in 8.162 Saltbr-in 2.985 HRD-in -66.01, -55.94 58.15, 19.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -113.83 APE8-dihe-out -84.15, 2.15 APE8-rot-out 169.53 APE67-dihe-in -57.24, -36.43 -90.25, -17.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.269 None None None XRAY 3.26 0.231 0.271 A 317 282 29 0 0 20 [[18, 292]] 1.0 6fu5 TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6S1FB 5 315 540.0 KRE:400 Type1 Inactive DFGin 6.089 14.552 BLAminus -136.13, -177.6 64.6, 77.45 -102.32, 33.61 287.44, 99.54 -74.42, -24.82 in-out in 8.507 Saltbr-out 4.332 HRD-in -68.09, -52.63 66.62, 10.13 out-in-out SNCoio in-out ActLoopNT-in 2.922 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -76.64 APE8-rot-out 48.4 APE67-dihe-in -60.75, -18.88 -96.32, -3.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.11 0.256 0.3 B 317 286 25 0 0 14 [[18, 292]] 1.0 6s1f TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6S1FD 5 316 540.0 KRE:400 Type1 Inactive DFGin 5.754 14.495 BLAminus -135.97, -176.52 66.84, 77.7 -101.6, 58.1 285.65, 99.66 -72.67, -42.59 in-in in 8.232 Saltbr-in 3.111 HRD-in -68.66, -53.79 68.01, 9.06 in-in-out SNCiio in-out ActLoopNT-in 3.561 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -44.09 APE8-dihe-out -55.97, -26.25 APE8-rot-out 47.91 APE67-dihe-in -63.85, -22.41 -93.96, -4.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.629 None None None XRAY 3.11 0.256 0.3 D 317 288 24 0 0 17 [[18, 292]] 1.0 6s1f TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5AR5A 4 310 540.0 IQ7:1312 Type1 Inactive DFGin 6.081 13.919 BLAminus -126.86, 179.69 62.84, 81.27 -103.15, 21.11 292.75, 77.76 -56.66, -44.59 in-in in 8.104 Saltbr-in 2.822 HRD-in -78.11, -46.09 56.4, 9.14 in-in-out SNCiio in-out ActLoopNT-in 2.806 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -92.65, 115.03 APE9-dihe-na -137.7, -171.82 APE8-dihe-in -72.24, 155.44 APE8-rot-out 54.69 APE67-dihe-in -55.38, -21.99 -110.33, -4.36 APE12-dist-none 999.0 APE11-dist-in 8.361 APE10-dist-out 12.093 APE9-dist-out 10.504 None None None XRAY 2.66 0.172 0.217 A 326 284 23 0 0 13 [[18, 292]] 1.0 5ar5 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5AR5B 4 310 540.0 IQ7:1311 Type1 Inactive DFGin 6.057 14.241 BLAminus -142.51, -179.66 67.74, 82.82 -106.87, 40.76 298.14, 96.55 -73.01, -50.49 in-in in 8.037 Saltbr-in 2.761 HRD-in -72.89, -56.07 62.45, 7.8 in-in-out SNCiio in-out ActLoopNT-in 2.829 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 150.41 APE8-rot-out 179.27 APE67-dihe-in -68.25, -17.91 -122.83, 8.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.66 0.172 0.217 B 326 279 28 0 0 17 [[18, 292]] 1.0 5ar5 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5J79A 2 310 540.0 6GE:401 Type1 Inactive DFGin 6.191 14.888 BLAminus -120.64, -169.71 53.95, 72.95 -94.42, 19.46 286.13, 70.88 -56.87, -46.79 in-in in 8.012 Saltbr-in 2.826 HRD-in -78.08, -43.76 61.31, -5.39 in-in-out SNCiio in-out ActLoopNT-in 2.843 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -79.71, 177.31 APE9-dihe-na 153.91, -173.6 APE8-dihe-in -106.59, 127.13 APE8-rot-in 297.35 APE67-dihe-in -52.69, -23.77 -40.38, -60.16 APE12-dist-in 12.205 APE11-dist-out 7.74 APE10-dist-in 6.158 APE9-dist-in 3.52 None None None XRAY 2.69 0.164 0.219 A 326 283 26 0 0 10 [[18, 292]] 1.0 5j79 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5J79B 5 310 540.0 6GE:401 Type1 Inactive DFGin 6.215 14.691 BLAminus -127.38, -171.48 58.91, 71.21 -93.63, 17.06 288.17, 81.6 -55.96, -36.73 in-in in 7.893 Saltbr-in 2.821 HRD-in -66.88, -48.06 57.22, 15.22 in-in-out SNCiio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -149.85 APE8-dihe-in -92.95, 137.0 APE8-rot-out 192.1 APE67-dihe-in -64.77, -22.33 -110.03, 6.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.119 None None None XRAY 2.69 0.164 0.219 B 326 277 29 0 0 15 [[18, 292]] 1.0 5j79 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5NG2A 5 298 540.0 STU:401 Type1 Inactive DFGin 5.959 13.876 BLAminus -127.83, 178.19 61.49, 80.49 -96.67, 24.09 288.33, 78.8 -62.82, -31.8 in-in in 8.091 Saltbr-in 2.902 HRD-in -73.87, -50.37 57.71, 19.44 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 149.89 APE8-dihe-in -77.86, 146.25 APE8-rot-out 189.94 APE67-dihe-in -66.59, -20.81 -105.1, 1.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.855 D146N None None XRAY 2.8 0.209 0.226 A 304 274 20 0 0 14 [[18, 292]] 1.0 5ng2 TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5NG2B 5 298 540.0 STU:401 Type1 Inactive DFGin 5.987 13.9 BLAminus -127.96, 178.42 61.45, 80.21 -96.5, 23.45 288.92, 78.23 -62.02, -31.71 in-in in 8.093 Saltbr-in 2.894 HRD-in -73.84, -50.5 58.4, 18.77 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.58 APE8-dihe-in -77.44, 145.88 APE8-rot-out 189.53 APE67-dihe-in -67.7, -20.58 -104.84, 1.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.79 D146N None None XRAY 2.8 0.209 0.226 B 304 278 16 0 0 15 [[18, 292]] 1.0 5ng2 TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6UL8A 5 310 540.0 Q9J:401 Type1.5_Back Inactive DFGin 6.085 13.904 BLAminus -138.68, 177.39 65.76, 84.99 -107.51, 38.57 290.05, 69.88 -77.69, -36.11 in-in in 7.96 Saltbr-in 3.186 HRD-in -69.43, -53.26 62.34, 12.17 in-in-out SNCiio in-out ActLoopNT-in 2.952 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -165.87 APE8-dihe-in -60.17, 149.46 APE8-rot-out 196.86 APE67-dihe-in -58.24, -30.16 -112.68, 2.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.538 C7S,S168C None None XRAY 2.68 0.185 0.22 A 306 279 27 0 0 17 [[18, 292]] 1.0 6ul8 TKL_RIPK2_HUMAN TKL 1.9e-72 250.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6UL8B 5 310 540.0 Q9J:402 Type1.5_Back Inactive DFGin 6.175 13.98 BLAminus -122.99, -178.46 65.81, 77.15 -98.02, 36.9 291.09, 78.99 -72.1, -29.98 in-in in 8.057 Saltbr-in 3.083 HRD-in -78.67, -48.07 63.33, 13.97 in-in-out SNCiio in-out ActLoopNT-in 2.702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -175.3 APE8-dihe-in -93.82, 150.28 APE8-rot-out 194.98 APE67-dihe-in -68.22, -20.36 -108.06, 1.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.478 C7S,S168C None None XRAY 2.68 0.185 0.22 B 306 283 23 0 0 17 [[18, 292]] 1.0 6ul8 TKL_RIPK2_HUMAN TKL 1.9e-72 250.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6RN8A 5 310 540.0 K9T:401 Type1.5_Back Inactive DFGin 6.098 13.891 BLAminus -121.2, -174.58 53.58, 84.93 -101.75, 30.28 282.16, 80.1 -71.87, -31.63 in-in in 7.981 Saltbr-in 2.871 HRD-in -66.39, -50.33 64.83, 11.58 in-in-out SNCiio in-out ActLoopNT-in 2.862 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.27 APE8-dihe-in -62.06, 149.59 APE8-rot-out 197.55 APE67-dihe-in -63.99, -18.48 -118.03, -0.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.624 None None None XRAY 2.69 0.178 0.212 A 311 281 25 0 0 15 [[18, 292]] 1.0 6rn8 TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6RN8B 5 310 540.0 K9T:402 Type1.5_Back Inactive DFGin 6.013 13.74 BLAminus -122.39, -174.33 51.92, 85.84 -100.82, 20.49 283.98, 79.06 -64.39, -29.28 in-in in 8.217 Saltbr-in 2.952 HRD-in -60.94, -56.67 69.44, 9.97 in-in-out SNCiio in-out ActLoopNT-in 2.825 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -139.63, -164.48 APE9-dihe-na -115.85, -133.91 APE8-dihe-in -56.11, 149.92 APE8-rot-out 199.64 APE67-dihe-in -63.61, -17.82 -118.75, -0.13 APE12-dist-none 999.0 APE11-dist-in 13.305 APE10-dist-out 10.53 APE9-dist-out 10.976 None None None XRAY 2.69 0.178 0.212 B 311 284 22 0 0 13 [[18, 292]] 1.0 6rn8 TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6RNAA 5 310 540.0 KA2:401 Type1.5_Back Inactive DFGin 6.096 14.119 BLAminus -118.69, -178.94 59.47, 86.33 -104.16, 26.83 288.87, 81.14 -69.66, -36.26 in-in in 8.021 Saltbr-in 2.871 HRD-in -59.8, -53.12 61.06, 18.18 in-in-out SNCiio in-out ActLoopNT-in 2.806 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -150.26 APE9-dihe-na -111.81, -125.99 APE8-dihe-in -71.22, 149.14 APE8-rot-out 191.73 APE67-dihe-in -63.27, -18.82 -116.66, -2.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.359 APE9-dist-out 10.608 None None None XRAY 2.62 0.162 0.19 A 311 277 29 0 0 14 [[18, 292]] 1.0 6rna TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6RNAB 4 310 540.0 KA2:401 Type1.5_Back Inactive DFGin 6.08 14.247 BLAminus -120.18, -176.72 60.07, 86.2 -105.54, 23.51 290.08, 82.68 -62.84, -38.47 in-in in 8.07 Saltbr-in 3.25 HRD-in -61.33, -52.71 61.11, 15.17 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -137.02, 170.76 APE9-dihe-na -116.32, -128.61 APE8-dihe-in -67.14, 150.22 APE8-rot-out 193.81 APE67-dihe-in -62.73, -17.87 -118.35, -1.43 APE12-dist-none 999.0 APE11-dist-in 11.91 APE10-dist-out 10.623 APE9-dist-out 11.103 None None None XRAY 2.62 0.162 0.19 B 311 284 23 0 0 13 [[18, 292]] 1.0 6rna TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
8X2OA 8 316 540.0 6IL:401 Type1.5_Back Inactive DFGin 6.108 14.063 BLAminus -124.76, -178.24 59.51, 83.58 -103.26, 21.59 286.78, 67.68 -61.63, -25.69 in-in in 8.172 Saltbr-in 2.899 HRD-in -73.25, -53.73 66.65, 12.78 in-in-out SNCiio in-out ActLoopNT-in 2.822 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -34.29 APE8-dihe-out -78.32, -9.99 APE8-rot-none 999.0 APE67-dihe-in -62.03, -22.4 -97.2, -12.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.708 None None None XRAY 2.26 0.215 0.254 A 316 278 31 0 0 16 [[18, 292]] 1.0 8x2o TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
8X2OB 9 316 540.0 6IL:401 Type1.5_Back Inactive DFGin 5.956 14.021 BLAminus -124.91, 179.9 57.85, 85.82 -101.47, 22.95 284.79, 67.03 -59.39, -22.8 in-in in 8.229 Saltbr-in 2.702 HRD-in -76.1, -54.35 62.81, 14.76 in-in-out SNCiio in-out ActLoopNT-in 2.681 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.95 APE8-dihe-out -77.16, -10.52 APE8-rot-out 66.48 APE67-dihe-in -64.46, -19.1 -99.04, -14.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.145 None None None XRAY 2.26 0.215 0.254 B 316 287 21 0 0 16 [[18, 292]] 1.0 8x2o TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6S1FA 5 316 540.0 KRE:400 Type1 Inactive DFGin 5.886 14.154 BLBminus -136.68, -174.64 68.69, 76.96 -104.64, -172.79 287.96, 1.48 75.58, -141.77 in-in in 7.921 Saltbr-in 2.894 HRD-in -68.42, -54.93 68.33, 10.57 in-out-out SNCioo out-out ActLoopNT-out 14.855 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -44.24 APE8-dihe-out -97.88, 11.31 APE8-rot-out 48.21 APE67-dihe-in -64.33, -18.5 -93.61, -4.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.713 None None None XRAY 3.11 0.256 0.3 A 317 291 21 0 0 16 [[18, 292]] 1.0 6s1f TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6S1FC 5 315 540.0 KRE:400 Type1 Inactive DFGin 6.418 14.466 BLBminus -136.0, -178.34 66.52, 77.3 -105.6, -150.08 288.38, 1.24 54.26, -143.32 in-in in 8.103 Saltbr-in 3.295 HRD-in -66.98, -53.6 67.88, 10.57 in-out-out SNCioo out-out ActLoopNT-out 14.677 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -39.08 APE8-dihe-out -92.13, -29.89 APE8-rot-out 48.51 APE67-dihe-in -60.41, -17.19 -93.43, -2.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.105 None None None XRAY 3.11 0.256 0.3 C 317 289 22 0 0 16 [[18, 292]] 1.0 6s1f TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5AR8B 8 310 540.0 XYW:1311 Type1.5_Back Inactive DFGin 6.445 14.548 BLBminus -138.31, -177.12 57.02, 46.97 -53.35, 139.38 296.36, 78.76 -77.07, 61.56 out-out out 11.72 Saltbr-out 9.673 HRD-in -73.74, -57.92 63.65, 13.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 6.02 APE9-dihe-na -70.75, 168.46 APE8-dihe-in -59.78, 148.4 APE8-rot-out 194.81 APE67-dihe-in -57.35, -6.9 -103.85, -13.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.425 APE9-dist-out 10.632 None None None XRAY 2.79 0.204 0.233 B 326 274 29 0 0 19 [[18, 292]] 1.0 5ar8 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5NG3A 8 297 540.0 No_ligand No_ligand Inactive DFGin 5.54 12.899 BLBplus -112.38, 160.58 70.97, 23.75 -68.8, 144.03 47.35, 86.99 65.51, 12.2 out-none out 12.751 Saltbr-none 999.0 HRD-in -71.1, -58.95 67.21, 2.05 none-out-out SNCnoo out-out ActLoopNT-out 9.789 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -127.51, 155.11 APE9-dihe-na -75.1, 166.99 APE8-dihe-in -61.92, 146.05 APE8-rot-out 193.53 APE67-dihe-in -56.91, -27.84 -109.89, 2.62 APE12-dist-none 999.0 APE11-dist-out 18.379 APE10-dist-out 14.87 APE9-dist-out 10.162 K47R TPO111 TPO111 XRAY 2.6 0.234 0.269 A 304 284 6 0 0 6 [[18, 292]] 1.0 5ng3 TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5NG3B 9 297 540.0 No_ligand No_ligand Inactive DFGin 5.67 12.901 BLBplus -112.34, 160.48 70.49, 24.2 -68.43, 144.17 47.17, 86.84 64.87, 12.81 out-none out 12.914 Saltbr-none 999.0 HRD-in -70.57, -58.52 66.45, 2.64 none-out-out SNCnoo out-out ActLoopNT-out 9.709 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -51.15 APE9-dihe-na -75.96, 168.48 APE8-dihe-in -61.9, 146.98 APE8-rot-out 192.74 APE67-dihe-in -54.8, -29.64 -109.73, 3.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.122 APE9-dist-out 9.641 K47R None None XRAY 2.6 0.234 0.269 B 304 275 14 0 0 8 [[18, 292]] 1.0 5ng3 TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5NG3C 9 297 540.0 No_ligand No_ligand Inactive DFGin 5.59 12.944 BLBplus -112.71, 161.13 70.64, 23.93 -68.42, 144.19 47.15, 87.05 64.5, 12.74 out-none out 12.845 Saltbr-none 999.0 HRD-in -71.02, -58.72 67.3, 1.13 none-out-out SNCnoo out-out ActLoopNT-out 9.816 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 160.87 APE8-dihe-in -62.18, 147.01 APE8-rot-out 192.72 APE67-dihe-in -54.87, -29.19 -109.49, 3.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.998 K47R None None XRAY 2.6 0.234 0.269 C 304 272 17 0 0 9 [[18, 292]] 1.0 5ng3 TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5NG3D 9 297 540.0 No_ligand No_ligand Inactive DFGin 5.574 12.889 BLBplus -112.39, 160.12 71.59, 23.49 -69.04, 143.91 48.32, 92.26 67.92, 12.12 out-none out 12.805 Saltbr-none 999.0 HRD-in -69.99, -59.28 66.07, 2.93 none-out-out SNCnoo out-out ActLoopNT-out 9.628 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -124.38, 144.23 APE9-dihe-na -74.77, 167.56 APE8-dihe-in -63.05, 146.04 APE8-rot-out 193.19 APE67-dihe-in -62.45, -21.47 -111.58, 2.98 APE12-dist-none 999.0 APE11-dist-out 18.215 APE10-dist-out 15.11 APE9-dist-out 10.148 K47R TPO111 TPO111 XRAY 2.6 0.234 0.269 D 304 279 10 0 0 6 [[18, 292]] 1.0 5ng3 TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6SZEA 5 310 540.0 M2B:401 Type1 Inactive DFGin 4.685 14.188 BLBplus -140.38, 176.81 56.22, 39.89 -108.75, 153.17 54.91, 95.34 65.03, 43.78 in-in in 7.701 Saltbr-in 2.821 HRD-in -69.61, -60.35 64.99, -5.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 142.75 APE8-rot-out 182.72 APE67-dihe-in -63.71, -17.61 -123.61, 3.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.94 0.179 0.234 A 311 274 32 0 0 20 [[18, 292]] 1.0 6sze TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6SZJA 5 310 540.0 M5W:401 Type1 Inactive DFGin 4.728 14.543 BLBplus -128.88, 175.29 56.57, 61.59 -132.22, 139.55 60.02, 89.16 45.92, 68.66 in-in in 7.842 Saltbr-in 3.596 HRD-in -66.36, -57.71 64.68, 3.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -118.11 APE8-dihe-in -97.65, 128.8 APE8-rot-out 180.19 APE67-dihe-in -65.16, -18.87 -95.83, 0.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.12 None None None XRAY 2.53 0.191 0.241 A 311 279 27 0 0 20 [[18, 292]] 1.0 6szj TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5AR4A 5 310 540.0 SB2:1311 Type1 Inactive DFGin 4.632 14.045 BLBplus -139.45, 166.57 61.79, 49.71 -115.35, 148.15 54.64, 94.62 62.79, 37.41 in-in in 7.645 Saltbr-in 2.821 HRD-in -68.8, -62.63 63.67, 2.11 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.58 APE8-rot-out 174.49 APE67-dihe-in -67.48, -22.2 -110.63, -5.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.18 0.216 A 326 274 32 0 0 21 [[18, 292]] 1.0 5ar4 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5AR4B 6 310 540.0 SB2:1311 Type1 Inactive DFGin 4.569 14.057 BLBplus -133.48, 172.27 57.95, 41.37 -105.11, 150.43 49.24, 89.44 68.18, 19.95 in-in in 7.579 Saltbr-in 2.904 HRD-in -72.79, -67.06 71.53, 1.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.45 APE8-dihe-in -96.06, 114.48 APE8-rot-out 179.92 APE67-dihe-in -54.67, -24.97 -78.06, -12.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.332 None None None XRAY 2.7 0.18 0.216 B 326 279 26 0 0 20 [[18, 292]] 1.0 5ar4 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5J7BA 5 310 540.0 6GD:401 Type1 Inactive DFGin 4.588 14.405 BLBplus -129.48, 168.3 62.65, 43.46 -109.82, 148.85 51.68, 86.16 70.79, 38.23 in-in in 7.867 Saltbr-in 2.889 HRD-in -71.32, -62.27 67.57, -0.37 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -116.74 APE8-dihe-in -88.25, 140.13 APE8-rot-out 180.7 APE67-dihe-in -66.48, -20.9 -107.99, 7.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.229 None None None XRAY 2.53 0.182 0.233 A 326 277 29 0 0 20 [[18, 292]] 1.0 5j7b TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5J7BB 4 310 540.0 6GD:401 Type1 Inactive DFGin 4.635 14.61 BLBplus -120.37, 168.05 63.64, 41.51 -106.03, 152.65 50.14, 87.53 73.72, 5.94 in-in in 7.976 Saltbr-in 2.768 HRD-in -76.48, -65.75 71.16, -2.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -95.83, 157.85 APE9-dihe-na -91.06, -150.2 APE8-dihe-in -80.84, 153.57 APE8-rot-out 185.33 APE67-dihe-in -54.63, -17.55 -109.62, -19.05 APE12-dist-none 999.0 APE11-dist-out 16.325 APE10-dist-out 13.722 APE9-dist-out 10.468 None None None XRAY 2.53 0.182 0.233 B 326 281 26 0 0 18 [[18, 292]] 1.0 5j7b TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5JA 9 310 540.0 9WS:401 Type1 Inactive DFGin 6.064 11.774 None -119.1, 58.24 -81.72, 48.17 -169.21, 999.0 29.16, 78.79 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-out -76.29, 33.51 -93.6, 157.22 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.86 APE8-rot-out 51.78 APE67-dihe-in -59.34, -25.23 -55.53, -13.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.22 0.268 A 310 251 51 0 0 23 [[18, 292]] 1.0 5w5j TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5W5JB 10 311 540.0 9WS:401 Type1 Inactive DFGin 10.664 12.427 None -117.65, 82.68 -113.99, 168.64 -106.24, 999.0 178.58, 75.53 999.0, 999.0 out-none out 12.734 Saltbr-none 999.0 HRD-none 999.0, -168.86 -106.07, -61.78 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.02 APE8-rot-out 182.83 APE67-dihe-in -59.02, -25.25 -78.75, -12.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.22 0.268 B 310 257 45 0 0 23 [[18, 292]] 1.0 5w5j TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6FU5B 5 316 540.0 E7N:400 Type1 Inactive DFGin 5.997 14.482 None -152.27, 168.89 72.98, 59.18 -85.18, 999.0 313.99, 145.21 999.0, 999.0 in-in in 8.254 Saltbr-in 3.292 HRD-in -67.82, -57.29 58.73, 20.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 33.08 APE8-dihe-out -121.2, 5.37 APE8-rot-out 45.9 APE67-dihe-in -54.25, -32.94 -85.9, -14.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.804 None None None XRAY 3.26 0.231 0.271 B 317 286 26 0 0 22 [[18, 292]] 1.0 6fu5 TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
9F3VA 9 314 540.0 A1H90:401 Type1 Inactive DFGin 6.12 11.632 None -123.15, 40.28 -90.71, 70.0 -87.39, 999.0 300.2, 126.34 999.0, 999.0 out-out out 12.459 Saltbr-out 11.392 HRD-out -117.23, 144.8 -142.51, 123.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.92 APE8-rot-out 194.2 APE67-dihe-in -71.3, -18.73 -128.19, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.943 0.222 0.256 A 320 271 35 0 0 23 [[18, 292]] 1.0 9f3v TKL_RIPK2_HUMAN TKL 5e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
9F3VB 9 315 540.0 A1H90:401 Type1 Inactive DFGin 6.159 11.184 None -124.64, 37.34 -86.49, 73.07 -88.12, -171.81 302.83, 123.42 -66.33, -25.78 out-out out 11.943 Saltbr-out 13.034 HRD-out -117.06, 146.57 -143.26, 122.43 out-out-out SNCooo out-out ActLoopNT-out 9.053 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.32 APE8-rot-out 190.74 APE67-dihe-in -70.4, -21.68 -126.9, 0.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.943 0.222 0.256 B 320 278 29 0 0 18 [[18, 292]] 1.0 9f3v TKL_RIPK2_HUMAN TKL 5e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5AR8A 9 310 540.0 XYW:1311 Type1.5_Back Inactive DFGin 6.492 13.737 None -145.13, 172.75 65.95, 57.21 -55.82, 999.0 299.0, 99.97 999.0, 999.0 out-out out 11.835 Saltbr-out 10.719 HRD-in -72.15, -51.23 60.29, 11.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -41.34 APE8-dihe-in -100.17, 152.95 APE8-rot-out 191.99 APE67-dihe-in -63.35, -16.88 -126.62, -2.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.041 None None None XRAY 2.79 0.204 0.233 A 326 255 47 0 0 22 [[18, 292]] 1.0 5ar8 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6ES0A 5 316 540.0 BW8:401 Type2 Inactive DFGout 14.121 8.923 BBAminus -138.52, -178.62 -150.57, 111.81 -84.27, -8.2 285.77, 101.08 -70.34, 157.2 in-in in 8.233 Saltbr-in 2.782 HRD-in -75.11, -58.32 62.84, 20.2 in-out-out SNCioo out-out ActLoopNT-out 10.271 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -68.98 APE8-dihe-out -81.68, 11.21 APE8-rot-out 56.58 APE67-dihe-in -75.1, -13.25 -106.14, -1.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.374 None None None XRAY 2.38 0.216 0.258 A 317 288 24 0 0 17 [[18, 292]] 1.0 6es0 TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
6ES0B 5 315 540.0 BW8:401 Type2 Inactive DFGout 14.043 9.066 BBAminus -137.57, -177.15 -156.56, 109.76 -81.72, 4.5 291.34, 90.75 -64.05, 168.24 in-in in 8.649 Saltbr-in 2.8 HRD-in -85.89, -59.6 64.07, 17.46 in-out-out SNCioo out-out ActLoopNT-out 10.838 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.42 APE8-dihe-in -71.95, 155.63 APE8-rot-out 184.48 APE67-dihe-in -73.42, -23.5 -115.93, 5.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.112 None None None XRAY 2.38 0.216 0.258 B 317 287 24 0 0 16 [[18, 292]] 1.0 6es0 TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5AR7B 6 310 540.0 SR8:1311 Type2 Inactive DFGout 14.124 8.748 BBAminus -122.07, 179.23 -147.51, 96.13 -66.21, -16.47 275.32, 92.13 58.18, 999.0 in-in in 7.844 Saltbr-in 2.817 HRD-in -67.02, -63.9 68.7, 14.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -175.85 APE8-dihe-in -67.25, 147.17 APE8-rot-out 32.44 APE67-dihe-in -57.24, -19.17 -103.63, -6.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.709 None None None XRAY 2.71 0.184 0.225 B 326 279 26 0 0 21 [[18, 292]] 1.0 5ar7 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
4C8BA 8 316 540.0 0LI:1000 Type2 Inactive DFGout 12.729 8.584 None -142.99, -175.55 -154.35, 140.4 -129.56, 999.0 290.55, 114.67 999.0, 999.0 in-in in 8.243 Saltbr-in 2.817 HRD-in -79.84, -58.2 64.89, 19.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.9 APE8-dihe-out -84.71, -55.98 APE8-rot-none 999.0 APE67-dihe-in -64.98, -25.64 -68.13, -16.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.294 None None None XRAY 2.75 0.203 0.244 A 334 279 30 0 0 22 [[18, 292]] 1.0 4c8b TKL_RIPK2_HUMAN TKL 3.4e-73 252.4 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
4C8BB 9 316 540.0 0LI:1000 Type2 Inactive DFGout 12.84 8.86 None -140.63, -176.63 -153.18, 138.54 -119.75, 999.0 285.35, 113.34 999.0, 999.0 in-in in 8.264 Saltbr-in 2.806 HRD-in -79.98, -59.74 66.42, 17.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -39.27 APE8-dihe-out -68.6, -38.75 APE8-rot-out 169.06 APE67-dihe-in -64.78, -24.38 -61.46, -15.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.445 None None None XRAY 2.75 0.203 0.244 B 334 281 27 0 0 22 [[18, 292]] 1.0 4c8b TKL_RIPK2_HUMAN TKL 3.4e-73 252.4 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
5AR7A 6 310 540.0 SR8:1311 Type2 Inactive DFGout 14.026 8.973 None -113.55, 174.5 -138.76, 94.08 -69.87, 134.61 275.21, 95.18 -123.3, 75.72 in-in in 7.765 Saltbr-in 2.813 HRD-in -59.22, -52.79 59.1, 6.82 in-out-out SNCioo out-out ActLoopNT-out 14.005 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 137.51 APE8-rot-out 192.27 APE67-dihe-in -58.31, -33.64 -121.66, -0.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.71 0.184 0.225 A 326 278 27 0 0 16 [[18, 292]] 1.0 5ar7 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2

TKL_RIPK2 (Receptor-interacting serine/threonine-protein kinase 2)

Total number of chains: 72
Active chains: 1
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 47 65.3% AF-O43353-K3A
DFGin BLBplus 10 13.9% 5NG3A
DFGin None 6 8.3% 6FU5B
DFGin BLBminus 3 4.2% 6S1FA
DFGout BBAminus 3 4.2% 6ES0A
DFGout None 3 4.2% 5AR7A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RIPK2_HUMAN AF-O43353-K3A O43353 10 300 540.0 No_ligand No_ligand Active DFGin 5.835 13.916 BLAminus -131.05, 176.49 59.07, 72.73 -86.61, 15.53 288.91, 79.18 -58.82, -34.9 in-in in 8.072 Saltbr-in 2.745 HRD-in -79.76, -41.87 62.78, -13.47 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -60.31, 147.35 APE9-dihe-na 163.97, 163.66 APE8-dihe-in -80.92, 119.55 APE8-rot-in 303.11 APE67-dihe-in -58.79, -31.16 -43.37, -46.06 APE12-dist-in 12.152 APE11-dist-in 8.69 APE10-dist-in 6.386 APE9-dist-in 3.816 None None None AF2 -1.0 1.0 1.0 A 291 291 0 0 0 0 [[18, 292]] 1.0 AF-O43353-K3 Homo sapiens TKL_RIPK2_HUMAN TKL 3.5e-73 252.3 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5NG0A O43353 6 300 540.0 ACP:1000 ATPlike Inactive DFGin 5.878 14.178 BLAminus -123.27, -179.27 62.78, 77.58 -93.4, 20.77 286.94, 75.81 -61.85, -28.6 in-in in 8.205 Saltbr-in 2.745 HRD-in -73.28, -52.62 66.02, 10.49 in-in-out SNCiio in-out ActLoopNT-in 2.847 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.46 APE8-dihe-in -72.18, 143.02 APE8-rot-out 185.7 APE67-dihe-in -65.61, -24.81 -104.28, 1.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8 L294F None None XRAY 2.0 0.171 0.191 A 304 274 21 0 0 15 [[18, 292]] 1.0 5ng0 Homo sapiens TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5NG0B O43353 5 299 540.0 ACP:401 ATPlike Inactive DFGin 5.887 14.177 BLAminus -123.03, -178.96 62.29, 77.78 -94.31, 21.44 286.41, 77.58 -63.12, -27.82 in-in in 8.16 Saltbr-in 2.756 HRD-in -74.08, -51.77 69.59, 3.54 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -72.33, -175.56 APE9-dihe-na 154.16, -172.85 APE8-dihe-in -105.14, 130.27 APE8-rot-in 300.55 APE67-dihe-in -61.64, -28.91 -51.09, -46.77 APE12-dist-in 11.85 APE11-dist-out 7.402 APE10-dist-in 6.02 APE9-dist-in 3.342 L294F None None XRAY 2.0 0.171 0.191 B 304 282 13 0 0 10 [[18, 292]] 1.0 5ng0 Homo sapiens TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5AR3A O43353 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.924 14.288 BLAminus -133.03, 175.56 72.21, 76.24 -97.68, 34.32 293.9, 86.68 -66.76, -37.47 in-in in 7.994 Saltbr-in 2.8 HRD-in -61.0, -40.82 51.84, 8.75 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -117.65 APE9-dihe-na 164.28, -57.84 APE8-dihe-in -114.77, 107.38 APE8-rot-out 185.6 APE67-dihe-in -64.24, -32.65 -95.4, 6.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.709 APE9-dist-out 10.828 None None None XRAY 3.23 0.192 0.254 A 326 279 26 0 0 14 [[18, 292]] 1.0 5ar3 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5AR3B O43353 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.87 14.418 BLAminus -128.31, 176.09 65.92, 78.1 -98.91, 35.33 294.64, 70.55 -68.55, -48.71 in-in in 8.021 Saltbr-in 2.88 HRD-in -65.19, -46.65 55.58, 8.54 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.98 APE8-rot-out 49.06 APE67-dihe-in -39.82, -41.25 -97.08, -7.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.23 0.192 0.254 B 326 276 29 0 0 16 [[18, 292]] 1.0 5ar3 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN AF-O43353-K1A O43353 10 300 540.0 No_ligand No_ligand Inactive DFGin 5.846 14.008 BLAminus -127.94, 175.85 61.05, 79.69 -94.57, 16.88 285.86, 79.13 -59.24, -35.38 in-in in 8.056 Saltbr-in 2.729 HRD-in -78.75, -47.93 64.43, -6.6 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -61.43, 170.33 APE9-dihe-na 162.37, 176.49 APE8-dihe-in -85.18, 118.94 APE8-rot-in 304.26 APE67-dihe-in -60.83, -35.85 -43.4, -45.78 APE12-dist-in 11.866 APE11-dist-out 7.591 APE10-dist-in 6.511 APE9-dist-in 3.494 None None None AF2 -1.0 1.0 1.0 A 291 291 0 0 0 0 [[18, 292]] 1.0 AF-O43353-K1 Homo sapiens TKL_RIPK2_HUMAN TKL 3.5e-73 252.3 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 8AZAA O43353 8 314 540.0 No_ligand No_ligand Inactive DFGin 6.638 14.972 BLAminus -149.95, -164.59 59.67, 64.47 -87.13, 14.1 289.04, 7.53 -62.24, -46.57 in-out in 9.738 Saltbr-out 8.893 HRD-in -64.59, -39.64 71.24, -10.99 out-in-out SNCoio in-out ActLoopNT-in 3.246 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.84 APE8-rot-out 77.29 APE67-dihe-in -86.62, -6.01 -67.77, -11.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.15 999.0 999.0 A 317 284 23 0 0 13 [[18, 292]] 1.0 8aza Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 8AZAB O43353 8 314 540.0 No_ligand No_ligand Inactive DFGin 5.335 13.551 BLAminus -130.42, -164.95 50.89, 68.36 -81.01, 15.64 291.47, 76.47 -59.33, -43.28 in-out in 7.362 Saltbr-out 5.606 HRD-in -91.72, -62.3 59.19, 5.81 out-in-none SNCoin in-none ActLoopNT-in 3.461 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.15 999.0 999.0 B 317 246 61 0 0 25 [[18, 292]] 1.0 8aza Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5AR2A O43353 4 310 540.0 No_ligand No_ligand Inactive DFGin 5.931 14.52 BLAminus -127.38, -176.39 62.31, 78.66 -95.92, 24.69 288.34, 80.55 -59.09, -44.11 in-in in 8.492 Saltbr-in 2.871 HRD-in -75.18, -53.25 68.8, 7.8 in-in-out SNCiio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 116.83 APE9-dihe-na -174.85, -153.32 APE8-dihe-in -65.24, 140.18 APE8-rot-out 190.57 APE67-dihe-in -65.15, -22.55 -115.33, 6.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.385 APE9-dist-out 10.606 None None None XRAY 2.44 0.172 0.211 A 326 277 30 0 0 14 [[18, 292]] 1.0 5ar2 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5AR2B O43353 4 310 540.0 No_ligand No_ligand Inactive DFGin 6.051 14.522 BLAminus -121.7, 177.66 61.53, 80.64 -98.26, 20.96 286.82, 74.03 -54.66, -35.04 in-in in 8.435 Saltbr-in 3.479 HRD-in -73.03, -54.01 65.44, 6.7 in-in-out SNCiio in-out ActLoopNT-in 2.862 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -62.83, 130.3 APE9-dihe-na -160.33, 164.95 APE8-dihe-in -67.1, 149.78 APE8-rot-out 186.39 APE67-dihe-in -54.03, -24.23 -110.46, -3.23 APE12-dist-in 11.972 APE11-dist-in 9.991 APE10-dist-out 13.044 APE9-dist-out 10.63 None None None XRAY 2.44 0.172 0.211 B 326 285 22 0 0 11 [[18, 292]] 1.0 5ar2 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OA O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.136 13.906 BLAminus -125.19, -174.64 59.09, 81.1 -106.86, 24.62 291.19, 85.74 -72.37, -32.43 in-none in 7.781 Saltbr-none 999.0 HRD-in -58.73, -48.93 54.24, 22.59 none-in-out SNCnio in-out ActLoopNT-in 2.779 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 52.01 APE8-dihe-in -88.74, 126.44 APE8-rot-out 182.28 APE67-dihe-in -69.67, -13.84 -102.91, 3.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.78 None None None XRAY 2.89 0.219 0.252 A 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OB O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.075 13.855 BLAminus -124.69, -174.05 60.01, 82.18 -107.5, 25.35 291.09, 85.35 -69.3, -34.49 in-none in 7.852 Saltbr-none 999.0 HRD-in -59.53, -49.22 54.97, 22.29 none-in-out SNCnio in-out ActLoopNT-in 2.796 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.07 APE8-dihe-in -82.18, 127.67 APE8-rot-out 181.47 APE67-dihe-in -70.21, -14.17 -102.49, 4.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.789 None None None XRAY 2.89 0.219 0.252 B 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OC O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 5.941 13.85 BLAminus -124.15, -173.26 59.49, 81.39 -107.32, 24.78 291.29, 84.01 -68.0, -35.39 in-none in 7.888 Saltbr-none 999.0 HRD-in -61.12, -47.92 53.98, 21.23 none-in-out SNCnio in-out ActLoopNT-in 2.789 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 58.39 APE8-dihe-in -87.67, 127.44 APE8-rot-out 182.78 APE67-dihe-in -69.34, -14.96 -102.25, 3.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.435 None None None XRAY 2.89 0.219 0.252 C 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OD O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1 13.76 BLAminus -124.11, -174.9 59.11, 83.61 -107.83, 24.21 291.26, 84.74 -71.93, -33.31 in-none in 7.712 Saltbr-none 999.0 HRD-in -58.77, -50.37 55.05, 21.57 none-in-out SNCnio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 52.34 APE8-dihe-in -81.49, 128.95 APE8-rot-out 42.92 APE67-dihe-in -70.09, -15.04 -103.55, 3.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.655 None None None XRAY 2.89 0.219 0.252 D 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OE O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.155 13.914 BLAminus -125.32, -175.39 59.04, 81.44 -106.24, 24.21 291.63, 86.05 -73.47, -30.79 in-in in 7.842 Saltbr-in 2.771 HRD-in -59.5, -48.44 53.52, 22.49 in-in-out SNCiio in-out ActLoopNT-in 2.77 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 63.28 APE8-dihe-in -87.25, 127.57 APE8-rot-out 182.11 APE67-dihe-in -69.71, -14.84 -102.46, 3.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.922 None None None XRAY 2.89 0.219 0.252 E 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OF O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.102 13.784 BLAminus -125.28, -174.81 60.87, 81.57 -107.6, 24.8 291.53, 85.38 -69.89, -33.64 in-none in 7.782 Saltbr-none 999.0 HRD-in -59.66, -48.54 55.22, 21.96 none-in-out SNCnio in-out ActLoopNT-in 2.792 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 60.19 APE8-dihe-in -79.96, 131.01 APE8-rot-out 181.63 APE67-dihe-in -71.08, -14.3 -102.18, 4.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.65 None None None XRAY 2.89 0.219 0.252 F 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OG O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.086 13.845 BLAminus -124.86, -174.91 60.12, 81.59 -107.81, 23.84 291.29, 84.93 -68.89, -36.67 in-none in 7.734 Saltbr-none 999.0 HRD-in -64.82, -49.86 54.77, 20.73 none-in-out SNCnio in-out ActLoopNT-in 2.787 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 60.09 APE8-dihe-in -78.03, 125.79 APE8-rot-out 184.52 APE67-dihe-in -69.81, -14.62 -102.95, 4.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.785 None None None XRAY 2.89 0.219 0.252 G 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OH O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.089 13.938 BLAminus -123.39, -173.38 58.61, 81.33 -105.97, 24.15 291.79, 83.79 -68.5, -35.98 in-in in 7.899 Saltbr-in 2.704 HRD-in -60.4, -48.42 54.87, 21.93 in-in-out SNCiio in-out ActLoopNT-in 2.787 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -55.03 APE8-dihe-in -80.95, 128.93 APE8-rot-out 42.89 APE67-dihe-in -69.91, -14.59 -102.1, 3.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.427 None None None XRAY 2.89 0.219 0.252 H 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OI O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 5.946 13.887 BLAminus -123.53, -172.96 57.44, 81.36 -106.55, 24.49 290.99, 84.39 -68.01, -35.42 in-none in 7.844 Saltbr-none 999.0 HRD-in -60.65, -52.84 62.49, 6.67 none-in-out SNCnio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -155.66 APE8-dihe-in -115.79, 147.83 APE8-rot-out 226.21 APE67-dihe-in -65.02, -15.65 -101.34, 1.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.417 None None None XRAY 2.89 0.219 0.252 I 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OJ O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.126 13.853 BLAminus -125.49, -173.66 60.26, 80.69 -107.0, 24.2 291.57, 84.27 -70.16, -35.59 in-in in 7.787 Saltbr-in 2.761 HRD-in -59.56, -49.0 54.34, 21.8 in-in-out SNCiio in-out ActLoopNT-in 2.809 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 62.31 APE8-dihe-in -78.64, 127.4 APE8-rot-out 183.39 APE67-dihe-in -70.3, -14.88 -101.54, 2.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.595 None None None XRAY 2.89 0.219 0.252 J 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OK O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.129 13.806 BLAminus -123.47, -174.04 59.2, 82.79 -107.55, 23.57 291.68, 84.11 -72.29, -31.81 in-in in 7.777 Saltbr-in 2.823 HRD-in -59.03, -50.17 55.62, 20.99 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 54.61 APE8-dihe-in -86.36, 126.77 APE8-rot-out 185.25 APE67-dihe-in -70.21, -14.67 -104.03, 4.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.933 None None None XRAY 2.89 0.219 0.252 K 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OL O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 5.977 13.872 BLAminus -123.97, -173.69 59.22, 81.96 -107.43, 24.71 291.89, 82.85 -67.15, -36.07 in-in in 7.91 Saltbr-in 2.745 HRD-in -60.31, -48.17 54.61, 21.38 in-in-out SNCiio in-out ActLoopNT-in 2.792 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 61.72 APE8-dihe-in -85.16, 131.31 APE8-rot-out 40.96 APE67-dihe-in -60.1, -15.62 -98.81, -9.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.391 None None None XRAY 2.89 0.219 0.252 L 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OM O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.106 13.875 BLAminus -124.12, -175.41 59.62, 81.55 -107.4, 24.65 291.81, 83.79 -71.72, -32.48 in-none in 7.797 Saltbr-none 999.0 HRD-in -58.16, -49.42 54.05, 21.71 none-in-out SNCnio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 41.26 APE8-dihe-in -78.53, 134.02 APE8-rot-out 36.01 APE67-dihe-in -69.76, -14.56 -101.27, 4.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.06 None None None XRAY 2.89 0.219 0.252 M 310 276 30 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5ON O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.079 13.928 BLAminus -124.88, -172.7 59.14, 81.77 -106.98, 23.8 291.97, 82.42 -69.42, -34.18 in-none in 7.947 Saltbr-none 999.0 HRD-in -59.84, -48.61 54.69, 21.04 none-in-out SNCnio in-out ActLoopNT-in 2.788 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 57.95 APE8-dihe-in -84.02, 128.93 APE8-rot-out 182.08 APE67-dihe-in -69.96, -13.84 -103.42, 3.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.652 None None None XRAY 2.89 0.219 0.252 N 310 272 34 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OO O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.184 13.824 BLAminus -123.94, -174.15 58.85, 81.43 -106.41, 23.33 291.99, 84.7 -71.56, -32.06 in-in in 7.791 Saltbr-in 2.791 HRD-in -58.13, -49.83 54.51, 21.43 in-in-out SNCiio in-out ActLoopNT-in 2.787 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 64.54 APE8-dihe-in -77.78, 132.07 APE8-rot-out 38.52 APE67-dihe-in -70.42, -14.07 -103.31, 4.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.389 None None None XRAY 2.89 0.219 0.252 O 310 276 30 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5OP O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.024 13.832 BLAminus -124.74, -174.78 59.93, 81.7 -106.98, 23.2 291.86, 82.87 -68.58, -34.35 in-none in 7.985 Saltbr-none 999.0 HRD-in -60.06, -48.48 54.27, 16.98 none-in-out SNCnio in-out ActLoopNT-in 2.792 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 52.76 APE8-dihe-in -83.36, 127.8 APE8-rot-out 182.51 APE67-dihe-in -70.3, -14.79 -101.64, 2.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.744 None None None XRAY 2.89 0.219 0.252 P 310 275 31 0 0 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6HMXA O43353 5 310 540.0 GEZ:401 Type1 Inactive DFGin 6.236 14.316 BLAminus -124.52, -177.56 66.8, 84.95 -109.14, 29.79 295.83, 94.07 -68.94, -45.49 in-in in 7.794 Saltbr-in 3.234 HRD-in -58.38, -60.47 64.01, 17.43 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -151.32 APE9-dihe-na -124.57, -125.51 APE8-dihe-in -82.66, 129.77 APE8-rot-out 187.19 APE67-dihe-in -64.93, -22.0 -95.67, -1.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.556 APE9-dist-out 10.447 None None None XRAY 2.53 0.166 0.192 A 311 280 26 0 0 15 [[18, 292]] 1.0 6hmx Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6HMXB O43353 5 310 540.0 GEZ:401 Type1 Inactive DFGin 6.186 14.368 BLAminus -124.43, -176.46 65.93, 86.3 -112.37, 30.95 293.81, 90.5 -69.1, -47.31 in-in in 7.919 Saltbr-in 3.156 HRD-in -59.3, -60.67 66.8, 11.61 in-in-out SNCiio in-out ActLoopNT-in 2.813 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 165.56 APE9-dihe-na -122.56, -147.83 APE8-dihe-in -59.45, 144.61 APE8-rot-out 192.64 APE67-dihe-in -62.6, -17.14 -111.83, -1.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.655 APE9-dist-out 11.168 None None None XRAY 2.53 0.166 0.192 B 311 282 24 0 0 14 [[18, 292]] 1.0 6hmx Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6SZEB O43353 5 310 540.0 M2B:402 Type1 Inactive DFGin 6.039 14.574 BLAminus -129.09, 175.84 70.06, 89.61 -113.49, 18.44 288.29, 86.33 -60.8, -47.17 in-in in 7.885 Saltbr-in 3.128 HRD-in -75.74, -46.99 56.85, -2.91 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -136.96, -159.87 APE9-dihe-na -128.34, -119.13 APE8-dihe-in -65.42, 150.34 APE8-rot-out 193.04 APE67-dihe-in -52.67, -15.51 -114.53, -21.66 APE12-dist-none 999.0 APE11-dist-in 12.84 APE10-dist-out 10.121 APE9-dist-out 11.041 None None None XRAY 2.94 0.179 0.234 B 311 276 30 0 0 15 [[18, 292]] 1.0 6sze Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6SZJB O43353 5 310 540.0 M5W:402 Type1 Inactive DFGin 6.06 14.803 BLAminus -127.62, -178.38 64.51, 85.71 -108.62, 30.49 299.07, 85.51 -62.99, -29.31 in-in in 8.036 Saltbr-in 2.624 HRD-in -73.84, -57.47 64.38, 3.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -111.13, -160.71 APE9-dihe-na -124.86, -125.22 APE8-dihe-in -69.02, 143.41 APE8-rot-out 187.62 APE67-dihe-in -53.68, -19.89 -104.22, -17.47 APE12-dist-none 999.0 APE11-dist-in 13.747 APE10-dist-out 10.385 APE9-dist-out 10.979 None None None XRAY 2.53 0.191 0.241 B 311 283 23 0 0 17 [[18, 292]] 1.0 6szj Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6FU5A O43353 5 315 540.0 E7N:400 Type1 Inactive DFGin 5.97 14.129 BLAminus -149.81, 168.35 73.17, 56.82 -87.36, -24.33 315.9, 145.59 -100.37, 169.03 in-in in 8.162 Saltbr-in 2.985 HRD-in -66.01, -55.94 58.15, 19.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -113.83 APE8-dihe-out -84.15, 2.15 APE8-rot-out 169.53 APE67-dihe-in -57.24, -36.43 -90.25, -17.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.269 None None None XRAY 3.26 0.231 0.271 A 317 282 29 0 0 20 [[18, 292]] 1.0 6fu5 Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6S1FB O43353 5 315 540.0 KRE:400 Type1 Inactive DFGin 6.089 14.552 BLAminus -136.13, -177.6 64.6, 77.45 -102.32, 33.61 287.44, 99.54 -74.42, -24.82 in-out in 8.507 Saltbr-out 4.332 HRD-in -68.09, -52.63 66.62, 10.13 out-in-out SNCoio in-out ActLoopNT-in 2.922 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -76.64 APE8-rot-out 48.4 APE67-dihe-in -60.75, -18.88 -96.32, -3.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.11 0.256 0.3 B 317 286 25 0 0 14 [[18, 292]] 1.0 6s1f Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6S1FD O43353 5 316 540.0 KRE:400 Type1 Inactive DFGin 5.754 14.495 BLAminus -135.97, -176.52 66.84, 77.7 -101.6, 58.1 285.65, 99.66 -72.67, -42.59 in-in in 8.232 Saltbr-in 3.111 HRD-in -68.66, -53.79 68.01, 9.06 in-in-out SNCiio in-out ActLoopNT-in 3.561 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -44.09 APE8-dihe-out -55.97, -26.25 APE8-rot-out 47.91 APE67-dihe-in -63.85, -22.41 -93.96, -4.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.629 None None None XRAY 3.11 0.256 0.3 D 317 288 24 0 0 17 [[18, 292]] 1.0 6s1f Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5AR5A O43353 4 310 540.0 IQ7:1312 Type1 Inactive DFGin 6.081 13.919 BLAminus -126.86, 179.69 62.84, 81.27 -103.15, 21.11 292.75, 77.76 -56.66, -44.59 in-in in 8.104 Saltbr-in 2.822 HRD-in -78.11, -46.09 56.4, 9.14 in-in-out SNCiio in-out ActLoopNT-in 2.806 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -92.65, 115.03 APE9-dihe-na -137.7, -171.82 APE8-dihe-in -72.24, 155.44 APE8-rot-out 54.69 APE67-dihe-in -55.38, -21.99 -110.33, -4.36 APE12-dist-none 999.0 APE11-dist-in 8.361 APE10-dist-out 12.093 APE9-dist-out 10.504 None None None XRAY 2.66 0.172 0.217 A 326 284 23 0 0 13 [[18, 292]] 1.0 5ar5 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5AR5B O43353 4 310 540.0 IQ7:1311 Type1 Inactive DFGin 6.057 14.241 BLAminus -142.51, -179.66 67.74, 82.82 -106.87, 40.76 298.14, 96.55 -73.01, -50.49 in-in in 8.037 Saltbr-in 2.761 HRD-in -72.89, -56.07 62.45, 7.8 in-in-out SNCiio in-out ActLoopNT-in 2.829 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 150.41 APE8-rot-out 179.27 APE67-dihe-in -68.25, -17.91 -122.83, 8.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.66 0.172 0.217 B 326 279 28 0 0 17 [[18, 292]] 1.0 5ar5 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5J79A O43353 2 310 540.0 6GE:401 Type1 Inactive DFGin 6.191 14.888 BLAminus -120.64, -169.71 53.95, 72.95 -94.42, 19.46 286.13, 70.88 -56.87, -46.79 in-in in 8.012 Saltbr-in 2.826 HRD-in -78.08, -43.76 61.31, -5.39 in-in-out SNCiio in-out ActLoopNT-in 2.843 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -79.71, 177.31 APE9-dihe-na 153.91, -173.6 APE8-dihe-in -106.59, 127.13 APE8-rot-in 297.35 APE67-dihe-in -52.69, -23.77 -40.38, -60.16 APE12-dist-in 12.205 APE11-dist-out 7.74 APE10-dist-in 6.158 APE9-dist-in 3.52 None None None XRAY 2.69 0.164 0.219 A 326 283 26 0 0 10 [[18, 292]] 1.0 5j79 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5J79B O43353 5 310 540.0 6GE:401 Type1 Inactive DFGin 6.215 14.691 BLAminus -127.38, -171.48 58.91, 71.21 -93.63, 17.06 288.17, 81.6 -55.96, -36.73 in-in in 7.893 Saltbr-in 2.821 HRD-in -66.88, -48.06 57.22, 15.22 in-in-out SNCiio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -149.85 APE8-dihe-in -92.95, 137.0 APE8-rot-out 192.1 APE67-dihe-in -64.77, -22.33 -110.03, 6.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.119 None None None XRAY 2.69 0.164 0.219 B 326 277 29 0 0 15 [[18, 292]] 1.0 5j79 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5NG2A O43353 5 298 540.0 STU:401 Type1 Inactive DFGin 5.959 13.876 BLAminus -127.83, 178.19 61.49, 80.49 -96.67, 24.09 288.33, 78.8 -62.82, -31.8 in-in in 8.091 Saltbr-in 2.902 HRD-in -73.87, -50.37 57.71, 19.44 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 149.89 APE8-dihe-in -77.86, 146.25 APE8-rot-out 189.94 APE67-dihe-in -66.59, -20.81 -105.1, 1.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.855 D146N None None XRAY 2.8 0.209 0.226 A 304 274 20 0 0 14 [[18, 292]] 1.0 5ng2 Homo sapiens TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5NG2B O43353 5 298 540.0 STU:401 Type1 Inactive DFGin 5.987 13.9 BLAminus -127.96, 178.42 61.45, 80.21 -96.5, 23.45 288.92, 78.23 -62.02, -31.71 in-in in 8.093 Saltbr-in 2.894 HRD-in -73.84, -50.5 58.4, 18.77 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.58 APE8-dihe-in -77.44, 145.88 APE8-rot-out 189.53 APE67-dihe-in -67.7, -20.58 -104.84, 1.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.79 D146N None None XRAY 2.8 0.209 0.226 B 304 278 16 0 0 15 [[18, 292]] 1.0 5ng2 Homo sapiens TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6UL8A O43353 5 310 540.0 Q9J:401 Type1.5_Back Inactive DFGin 6.085 13.904 BLAminus -138.68, 177.39 65.76, 84.99 -107.51, 38.57 290.05, 69.88 -77.69, -36.11 in-in in 7.96 Saltbr-in 3.186 HRD-in -69.43, -53.26 62.34, 12.17 in-in-out SNCiio in-out ActLoopNT-in 2.952 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -165.87 APE8-dihe-in -60.17, 149.46 APE8-rot-out 196.86 APE67-dihe-in -58.24, -30.16 -112.68, 2.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.538 C7S,S168C None None XRAY 2.68 0.185 0.22 A 306 279 27 0 0 17 [[18, 292]] 1.0 6ul8 Homo sapiens TKL_RIPK2_HUMAN TKL 1.9e-72 250.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6UL8B O43353 5 310 540.0 Q9J:402 Type1.5_Back Inactive DFGin 6.175 13.98 BLAminus -122.99, -178.46 65.81, 77.15 -98.02, 36.9 291.09, 78.99 -72.1, -29.98 in-in in 8.057 Saltbr-in 3.083 HRD-in -78.67, -48.07 63.33, 13.97 in-in-out SNCiio in-out ActLoopNT-in 2.702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -175.3 APE8-dihe-in -93.82, 150.28 APE8-rot-out 194.98 APE67-dihe-in -68.22, -20.36 -108.06, 1.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.478 C7S,S168C None None XRAY 2.68 0.185 0.22 B 306 283 23 0 0 17 [[18, 292]] 1.0 6ul8 Homo sapiens TKL_RIPK2_HUMAN TKL 1.9e-72 250.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6RN8A O43353 5 310 540.0 K9T:401 Type1.5_Back Inactive DFGin 6.098 13.891 BLAminus -121.2, -174.58 53.58, 84.93 -101.75, 30.28 282.16, 80.1 -71.87, -31.63 in-in in 7.981 Saltbr-in 2.871 HRD-in -66.39, -50.33 64.83, 11.58 in-in-out SNCiio in-out ActLoopNT-in 2.862 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.27 APE8-dihe-in -62.06, 149.59 APE8-rot-out 197.55 APE67-dihe-in -63.99, -18.48 -118.03, -0.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.624 None None None XRAY 2.69 0.178 0.212 A 311 281 25 0 0 15 [[18, 292]] 1.0 6rn8 Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6RN8B O43353 5 310 540.0 K9T:402 Type1.5_Back Inactive DFGin 6.013 13.74 BLAminus -122.39, -174.33 51.92, 85.84 -100.82, 20.49 283.98, 79.06 -64.39, -29.28 in-in in 8.217 Saltbr-in 2.952 HRD-in -60.94, -56.67 69.44, 9.97 in-in-out SNCiio in-out ActLoopNT-in 2.825 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -139.63, -164.48 APE9-dihe-na -115.85, -133.91 APE8-dihe-in -56.11, 149.92 APE8-rot-out 199.64 APE67-dihe-in -63.61, -17.82 -118.75, -0.13 APE12-dist-none 999.0 APE11-dist-in 13.305 APE10-dist-out 10.53 APE9-dist-out 10.976 None None None XRAY 2.69 0.178 0.212 B 311 284 22 0 0 13 [[18, 292]] 1.0 6rn8 Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6RNAA O43353 5 310 540.0 KA2:401 Type1.5_Back Inactive DFGin 6.096 14.119 BLAminus -118.69, -178.94 59.47, 86.33 -104.16, 26.83 288.87, 81.14 -69.66, -36.26 in-in in 8.021 Saltbr-in 2.871 HRD-in -59.8, -53.12 61.06, 18.18 in-in-out SNCiio in-out ActLoopNT-in 2.806 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -150.26 APE9-dihe-na -111.81, -125.99 APE8-dihe-in -71.22, 149.14 APE8-rot-out 191.73 APE67-dihe-in -63.27, -18.82 -116.66, -2.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.359 APE9-dist-out 10.608 None None None XRAY 2.62 0.162 0.19 A 311 277 29 0 0 14 [[18, 292]] 1.0 6rna Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6RNAB O43353 4 310 540.0 KA2:401 Type1.5_Back Inactive DFGin 6.08 14.247 BLAminus -120.18, -176.72 60.07, 86.2 -105.54, 23.51 290.08, 82.68 -62.84, -38.47 in-in in 8.07 Saltbr-in 3.25 HRD-in -61.33, -52.71 61.11, 15.17 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -137.02, 170.76 APE9-dihe-na -116.32, -128.61 APE8-dihe-in -67.14, 150.22 APE8-rot-out 193.81 APE67-dihe-in -62.73, -17.87 -118.35, -1.43 APE12-dist-none 999.0 APE11-dist-in 11.91 APE10-dist-out 10.623 APE9-dist-out 11.103 None None None XRAY 2.62 0.162 0.19 B 311 284 23 0 0 13 [[18, 292]] 1.0 6rna Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 8X2OA O43353 8 316 540.0 6IL:401 Type1.5_Back Inactive DFGin 6.108 14.063 BLAminus -124.76, -178.24 59.51, 83.58 -103.26, 21.59 286.78, 67.68 -61.63, -25.69 in-in in 8.172 Saltbr-in 2.899 HRD-in -73.25, -53.73 66.65, 12.78 in-in-out SNCiio in-out ActLoopNT-in 2.822 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -34.29 APE8-dihe-out -78.32, -9.99 APE8-rot-none 999.0 APE67-dihe-in -62.03, -22.4 -97.2, -12.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.708 None None None XRAY 2.26 0.215 0.254 A 316 278 31 0 0 16 [[18, 292]] 1.0 8x2o Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 8X2OB O43353 9 316 540.0 6IL:401 Type1.5_Back Inactive DFGin 5.956 14.021 BLAminus -124.91, 179.9 57.85, 85.82 -101.47, 22.95 284.79, 67.03 -59.39, -22.8 in-in in 8.229 Saltbr-in 2.702 HRD-in -76.1, -54.35 62.81, 14.76 in-in-out SNCiio in-out ActLoopNT-in 2.681 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.95 APE8-dihe-out -77.16, -10.52 APE8-rot-out 66.48 APE67-dihe-in -64.46, -19.1 -99.04, -14.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.145 None None None XRAY 2.26 0.215 0.254 B 316 287 21 0 0 16 [[18, 292]] 1.0 8x2o Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6S1FA O43353 5 316 540.0 KRE:400 Type1 Inactive DFGin 5.886 14.154 BLBminus -136.68, -174.64 68.69, 76.96 -104.64, -172.79 287.96, 1.48 75.58, -141.77 in-in in 7.921 Saltbr-in 2.894 HRD-in -68.42, -54.93 68.33, 10.57 in-out-out SNCioo out-out ActLoopNT-out 14.855 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -44.24 APE8-dihe-out -97.88, 11.31 APE8-rot-out 48.21 APE67-dihe-in -64.33, -18.5 -93.61, -4.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.713 None None None XRAY 3.11 0.256 0.3 A 317 291 21 0 0 16 [[18, 292]] 1.0 6s1f Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6S1FC O43353 5 315 540.0 KRE:400 Type1 Inactive DFGin 6.418 14.466 BLBminus -136.0, -178.34 66.52, 77.3 -105.6, -150.08 288.38, 1.24 54.26, -143.32 in-in in 8.103 Saltbr-in 3.295 HRD-in -66.98, -53.6 67.88, 10.57 in-out-out SNCioo out-out ActLoopNT-out 14.677 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -39.08 APE8-dihe-out -92.13, -29.89 APE8-rot-out 48.51 APE67-dihe-in -60.41, -17.19 -93.43, -2.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.105 None None None XRAY 3.11 0.256 0.3 C 317 289 22 0 0 16 [[18, 292]] 1.0 6s1f Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5AR8B O43353 8 310 540.0 XYW:1311 Type1.5_Back Inactive DFGin 6.445 14.548 BLBminus -138.31, -177.12 57.02, 46.97 -53.35, 139.38 296.36, 78.76 -77.07, 61.56 out-out out 11.72 Saltbr-out 9.673 HRD-in -73.74, -57.92 63.65, 13.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 6.02 APE9-dihe-na -70.75, 168.46 APE8-dihe-in -59.78, 148.4 APE8-rot-out 194.81 APE67-dihe-in -57.35, -6.9 -103.85, -13.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.425 APE9-dist-out 10.632 None None None XRAY 2.79 0.204 0.233 B 326 274 29 0 0 19 [[18, 292]] 1.0 5ar8 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5NG3A O43353 8 297 540.0 No_ligand No_ligand Inactive DFGin 5.54 12.899 BLBplus -112.38, 160.58 70.97, 23.75 -68.8, 144.03 47.35, 86.99 65.51, 12.2 out-none out 12.751 Saltbr-none 999.0 HRD-in -71.1, -58.95 67.21, 2.05 none-out-out SNCnoo out-out ActLoopNT-out 9.789 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -127.51, 155.11 APE9-dihe-na -75.1, 166.99 APE8-dihe-in -61.92, 146.05 APE8-rot-out 193.53 APE67-dihe-in -56.91, -27.84 -109.89, 2.62 APE12-dist-none 999.0 APE11-dist-out 18.379 APE10-dist-out 14.87 APE9-dist-out 10.162 K47R TPO111 TPO111 XRAY 2.6 0.234 0.269 A 304 284 6 0 0 6 [[18, 292]] 1.0 5ng3 Homo sapiens TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5NG3B O43353 9 297 540.0 No_ligand No_ligand Inactive DFGin 5.67 12.901 BLBplus -112.34, 160.48 70.49, 24.2 -68.43, 144.17 47.17, 86.84 64.87, 12.81 out-none out 12.914 Saltbr-none 999.0 HRD-in -70.57, -58.52 66.45, 2.64 none-out-out SNCnoo out-out ActLoopNT-out 9.709 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -51.15 APE9-dihe-na -75.96, 168.48 APE8-dihe-in -61.9, 146.98 APE8-rot-out 192.74 APE67-dihe-in -54.8, -29.64 -109.73, 3.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.122 APE9-dist-out 9.641 K47R None None XRAY 2.6 0.234 0.269 B 304 275 14 0 0 8 [[18, 292]] 1.0 5ng3 Homo sapiens TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5NG3C O43353 9 297 540.0 No_ligand No_ligand Inactive DFGin 5.59 12.944 BLBplus -112.71, 161.13 70.64, 23.93 -68.42, 144.19 47.15, 87.05 64.5, 12.74 out-none out 12.845 Saltbr-none 999.0 HRD-in -71.02, -58.72 67.3, 1.13 none-out-out SNCnoo out-out ActLoopNT-out 9.816 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 160.87 APE8-dihe-in -62.18, 147.01 APE8-rot-out 192.72 APE67-dihe-in -54.87, -29.19 -109.49, 3.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.998 K47R None None XRAY 2.6 0.234 0.269 C 304 272 17 0 0 9 [[18, 292]] 1.0 5ng3 Homo sapiens TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5NG3D O43353 9 297 540.0 No_ligand No_ligand Inactive DFGin 5.574 12.889 BLBplus -112.39, 160.12 71.59, 23.49 -69.04, 143.91 48.32, 92.26 67.92, 12.12 out-none out 12.805 Saltbr-none 999.0 HRD-in -69.99, -59.28 66.07, 2.93 none-out-out SNCnoo out-out ActLoopNT-out 9.628 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -124.38, 144.23 APE9-dihe-na -74.77, 167.56 APE8-dihe-in -63.05, 146.04 APE8-rot-out 193.19 APE67-dihe-in -62.45, -21.47 -111.58, 2.98 APE12-dist-none 999.0 APE11-dist-out 18.215 APE10-dist-out 15.11 APE9-dist-out 10.148 K47R TPO111 TPO111 XRAY 2.6 0.234 0.269 D 304 279 10 0 0 6 [[18, 292]] 1.0 5ng3 Homo sapiens TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6SZEA O43353 5 310 540.0 M2B:401 Type1 Inactive DFGin 4.685 14.188 BLBplus -140.38, 176.81 56.22, 39.89 -108.75, 153.17 54.91, 95.34 65.03, 43.78 in-in in 7.701 Saltbr-in 2.821 HRD-in -69.61, -60.35 64.99, -5.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 142.75 APE8-rot-out 182.72 APE67-dihe-in -63.71, -17.61 -123.61, 3.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.94 0.179 0.234 A 311 274 32 0 0 20 [[18, 292]] 1.0 6sze Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6SZJA O43353 5 310 540.0 M5W:401 Type1 Inactive DFGin 4.728 14.543 BLBplus -128.88, 175.29 56.57, 61.59 -132.22, 139.55 60.02, 89.16 45.92, 68.66 in-in in 7.842 Saltbr-in 3.596 HRD-in -66.36, -57.71 64.68, 3.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -118.11 APE8-dihe-in -97.65, 128.8 APE8-rot-out 180.19 APE67-dihe-in -65.16, -18.87 -95.83, 0.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.12 None None None XRAY 2.53 0.191 0.241 A 311 279 27 0 0 20 [[18, 292]] 1.0 6szj Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5AR4A O43353 5 310 540.0 SB2:1311 Type1 Inactive DFGin 4.632 14.045 BLBplus -139.45, 166.57 61.79, 49.71 -115.35, 148.15 54.64, 94.62 62.79, 37.41 in-in in 7.645 Saltbr-in 2.821 HRD-in -68.8, -62.63 63.67, 2.11 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.58 APE8-rot-out 174.49 APE67-dihe-in -67.48, -22.2 -110.63, -5.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.18 0.216 A 326 274 32 0 0 21 [[18, 292]] 1.0 5ar4 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5AR4B O43353 6 310 540.0 SB2:1311 Type1 Inactive DFGin 4.569 14.057 BLBplus -133.48, 172.27 57.95, 41.37 -105.11, 150.43 49.24, 89.44 68.18, 19.95 in-in in 7.579 Saltbr-in 2.904 HRD-in -72.79, -67.06 71.53, 1.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.45 APE8-dihe-in -96.06, 114.48 APE8-rot-out 179.92 APE67-dihe-in -54.67, -24.97 -78.06, -12.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.332 None None None XRAY 2.7 0.18 0.216 B 326 279 26 0 0 20 [[18, 292]] 1.0 5ar4 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5J7BA O43353 5 310 540.0 6GD:401 Type1 Inactive DFGin 4.588 14.405 BLBplus -129.48, 168.3 62.65, 43.46 -109.82, 148.85 51.68, 86.16 70.79, 38.23 in-in in 7.867 Saltbr-in 2.889 HRD-in -71.32, -62.27 67.57, -0.37 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -116.74 APE8-dihe-in -88.25, 140.13 APE8-rot-out 180.7 APE67-dihe-in -66.48, -20.9 -107.99, 7.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.229 None None None XRAY 2.53 0.182 0.233 A 326 277 29 0 0 20 [[18, 292]] 1.0 5j7b Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5J7BB O43353 4 310 540.0 6GD:401 Type1 Inactive DFGin 4.635 14.61 BLBplus -120.37, 168.05 63.64, 41.51 -106.03, 152.65 50.14, 87.53 73.72, 5.94 in-in in 7.976 Saltbr-in 2.768 HRD-in -76.48, -65.75 71.16, -2.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -95.83, 157.85 APE9-dihe-na -91.06, -150.2 APE8-dihe-in -80.84, 153.57 APE8-rot-out 185.33 APE67-dihe-in -54.63, -17.55 -109.62, -19.05 APE12-dist-none 999.0 APE11-dist-out 16.325 APE10-dist-out 13.722 APE9-dist-out 10.468 None None None XRAY 2.53 0.182 0.233 B 326 281 26 0 0 18 [[18, 292]] 1.0 5j7b Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5JA O43353 9 310 540.0 9WS:401 Type1 Inactive DFGin 6.064 11.774 None -119.1, 58.24 -81.72, 48.17 -169.21, 999.0 29.16, 78.79 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-out -76.29, 33.51 -93.6, 157.22 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.86 APE8-rot-out 51.78 APE67-dihe-in -59.34, -25.23 -55.53, -13.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.22 0.268 A 310 251 51 0 0 23 [[18, 292]] 1.0 5w5j Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5W5JB O43353 10 311 540.0 9WS:401 Type1 Inactive DFGin 10.664 12.427 None -117.65, 82.68 -113.99, 168.64 -106.24, 999.0 178.58, 75.53 999.0, 999.0 out-none out 12.734 Saltbr-none 999.0 HRD-none 999.0, -168.86 -106.07, -61.78 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.02 APE8-rot-out 182.83 APE67-dihe-in -59.02, -25.25 -78.75, -12.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.22 0.268 B 310 257 45 0 0 23 [[18, 292]] 1.0 5w5j Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6FU5B O43353 5 316 540.0 E7N:400 Type1 Inactive DFGin 5.997 14.482 None -152.27, 168.89 72.98, 59.18 -85.18, 999.0 313.99, 145.21 999.0, 999.0 in-in in 8.254 Saltbr-in 3.292 HRD-in -67.82, -57.29 58.73, 20.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 33.08 APE8-dihe-out -121.2, 5.37 APE8-rot-out 45.9 APE67-dihe-in -54.25, -32.94 -85.9, -14.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.804 None None None XRAY 3.26 0.231 0.271 B 317 286 26 0 0 22 [[18, 292]] 1.0 6fu5 Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 9F3VA O43353 9 314 540.0 A1H90:401 Type1 Inactive DFGin 6.12 11.632 None -123.15, 40.28 -90.71, 70.0 -87.39, 999.0 300.2, 126.34 999.0, 999.0 out-out out 12.459 Saltbr-out 11.392 HRD-out -117.23, 144.8 -142.51, 123.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.92 APE8-rot-out 194.2 APE67-dihe-in -71.3, -18.73 -128.19, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.943 0.222 0.256 A 320 271 35 0 0 23 [[18, 292]] 1.0 9f3v Homo sapiens TKL_RIPK2_HUMAN TKL 5e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 9F3VB O43353 9 315 540.0 A1H90:401 Type1 Inactive DFGin 6.159 11.184 None -124.64, 37.34 -86.49, 73.07 -88.12, -171.81 302.83, 123.42 -66.33, -25.78 out-out out 11.943 Saltbr-out 13.034 HRD-out -117.06, 146.57 -143.26, 122.43 out-out-out SNCooo out-out ActLoopNT-out 9.053 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.32 APE8-rot-out 190.74 APE67-dihe-in -70.4, -21.68 -126.9, 0.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.943 0.222 0.256 B 320 278 29 0 0 18 [[18, 292]] 1.0 9f3v Homo sapiens TKL_RIPK2_HUMAN TKL 5e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5AR8A O43353 9 310 540.0 XYW:1311 Type1.5_Back Inactive DFGin 6.492 13.737 None -145.13, 172.75 65.95, 57.21 -55.82, 999.0 299.0, 99.97 999.0, 999.0 out-out out 11.835 Saltbr-out 10.719 HRD-in -72.15, -51.23 60.29, 11.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -41.34 APE8-dihe-in -100.17, 152.95 APE8-rot-out 191.99 APE67-dihe-in -63.35, -16.88 -126.62, -2.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.041 None None None XRAY 2.79 0.204 0.233 A 326 255 47 0 0 22 [[18, 292]] 1.0 5ar8 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6ES0A O43353 5 316 540.0 BW8:401 Type2 Inactive DFGout 14.121 8.923 BBAminus -138.52, -178.62 -150.57, 111.81 -84.27, -8.2 285.77, 101.08 -70.34, 157.2 in-in in 8.233 Saltbr-in 2.782 HRD-in -75.11, -58.32 62.84, 20.2 in-out-out SNCioo out-out ActLoopNT-out 10.271 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -68.98 APE8-dihe-out -81.68, 11.21 APE8-rot-out 56.58 APE67-dihe-in -75.1, -13.25 -106.14, -1.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.374 None None None XRAY 2.38 0.216 0.258 A 317 288 24 0 0 17 [[18, 292]] 1.0 6es0 Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 6ES0B O43353 5 315 540.0 BW8:401 Type2 Inactive DFGout 14.043 9.066 BBAminus -137.57, -177.15 -156.56, 109.76 -81.72, 4.5 291.34, 90.75 -64.05, 168.24 in-in in 8.649 Saltbr-in 2.8 HRD-in -85.89, -59.6 64.07, 17.46 in-out-out SNCioo out-out ActLoopNT-out 10.838 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.42 APE8-dihe-in -71.95, 155.63 APE8-rot-out 184.48 APE67-dihe-in -73.42, -23.5 -115.93, 5.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.112 None None None XRAY 2.38 0.216 0.258 B 317 287 24 0 0 16 [[18, 292]] 1.0 6es0 Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5AR7B O43353 6 310 540.0 SR8:1311 Type2 Inactive DFGout 14.124 8.748 BBAminus -122.07, 179.23 -147.51, 96.13 -66.21, -16.47 275.32, 92.13 58.18, 999.0 in-in in 7.844 Saltbr-in 2.817 HRD-in -67.02, -63.9 68.7, 14.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -175.85 APE8-dihe-in -67.25, 147.17 APE8-rot-out 32.44 APE67-dihe-in -57.24, -19.17 -103.63, -6.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.709 None None None XRAY 2.71 0.184 0.225 B 326 279 26 0 0 21 [[18, 292]] 1.0 5ar7 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 4C8BA O43353 8 316 540.0 0LI:1000 Type2 Inactive DFGout 12.729 8.584 None -142.99, -175.55 -154.35, 140.4 -129.56, 999.0 290.55, 114.67 999.0, 999.0 in-in in 8.243 Saltbr-in 2.817 HRD-in -79.84, -58.2 64.89, 19.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.9 APE8-dihe-out -84.71, -55.98 APE8-rot-none 999.0 APE67-dihe-in -64.98, -25.64 -68.13, -16.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.294 None None None XRAY 2.75 0.203 0.244 A 334 279 30 0 0 22 [[18, 292]] 1.0 4c8b Homo sapiens TKL_RIPK2_HUMAN TKL 3.4e-73 252.4 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 4C8BB O43353 9 316 540.0 0LI:1000 Type2 Inactive DFGout 12.84 8.86 None -140.63, -176.63 -153.18, 138.54 -119.75, 999.0 285.35, 113.34 999.0, 999.0 in-in in 8.264 Saltbr-in 2.806 HRD-in -79.98, -59.74 66.42, 17.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -39.27 APE8-dihe-out -68.6, -38.75 APE8-rot-out 169.06 APE67-dihe-in -64.78, -24.38 -61.46, -15.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.445 None None None XRAY 2.75 0.203 0.244 B 334 281 27 0 0 22 [[18, 292]] 1.0 4c8b Homo sapiens TKL_RIPK2_HUMAN TKL 3.4e-73 252.4 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2_HUMAN 5AR7A O43353 6 310 540.0 SR8:1311 Type2 Inactive DFGout 14.026 8.973 None -113.55, 174.5 -138.76, 94.08 -69.87, 134.61 275.21, 95.18 -123.3, 75.72 in-in in 7.765 Saltbr-in 2.813 HRD-in -59.22, -52.79 59.1, 6.82 in-out-out SNCioo out-out ActLoopNT-out 14.005 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 137.51 APE8-rot-out 192.27 APE67-dihe-in -58.31, -33.64 -121.66, -0.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.71 0.184 0.225 A 326 278 27 0 0 16 [[18, 292]] 1.0 5ar7 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2

TKL_RIPK2 (Receptor-interacting serine/threonine-protein kinase 2)

Total number of chains: 0
Active chains: 0
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name