TKL_RIPK2 (Receptor-interacting serine/threonine-protein kinase 2)

Total number of chains: 72
Active chains: 1
Uniprot: RIPK2_HUMAN
Kinase Domain Residues: 18 - 292
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 47 65.3% AF-O43353-K3A
DFGin BLBplus 10 13.9% 5NG3A
DFGin None 6 8.3% 6FU5B
DFGin BLBminus 3 4.2% 6S1FA
DFGout BBAminus 3 4.2% 6ES0A
DFGout None 3 4.2% 5AR7A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RIPK2 AF-O43353-K3A O43353 10 300 540.0 No_ligand No_ligand Active DFGin 5.8355 13.9164 BLAminus -131.05, 176.49 59.07, 72.73 -86.61, 15.53 288.91, 79.18 -58.82, -34.9 in-in in 8.0725 Saltbr-in 2.7454 HRD-in -79.76, -41.87 62.78, -13.47 in-in-in SNCiii in-in ActLoopNT-in 2.8929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -60.31, 147.35 APE9-dihe-na 163.97, 163.66 APE8-dihe-in -80.92, 119.55 APE8-rot-in 303.11 APE67-dihe-in -58.79, -31.16 -43.37, -46.06 APE12-dist-in 12.1519 APE11-dist-in 8.6903 APE10-dist-in 6.3862 APE9-dist-in 3.8157 None None None AF2 -1.0 1.0 1.0 A 291.0 291.0 0 33 33 0 [[18, 292]] 1.0 AF-O43353-K3 TKL_RIPK2_HUMAN TKL 3.5e-73 252.3 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5NG0A O43353 6 300 540.0 ACP:1000 ATPlike Inactive DFGin 5.8784 14.1777 BLAminus -123.27, -179.27 62.78, 77.58 -93.4, 20.77 286.94, 75.81 -61.85, -28.6 in-in in 8.2049 Saltbr-in 2.7453 HRD-in -73.28, -52.62 66.02, 10.49 in-in-out SNCiio in-out ActLoopNT-in 2.8467 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.46 APE8-dihe-in -72.18, 143.02 APE8-rot-out 185.7 APE67-dihe-in -65.61, -24.81 -104.28, 1.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8005 L294F None None XRAY 2.0 0.171 0.191 A 304.0 274.0 21 33 18 15 [[18, 292]] 1.0 5ng0 TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5NG0B O43353 5 299 540.0 ACP:401 ATPlike Inactive DFGin 5.8866 14.1774 BLAminus -123.03, -178.96 62.29, 77.78 -94.31, 21.44 286.41, 77.58 -63.12, -27.82 in-in in 8.1596 Saltbr-in 2.756 HRD-in -74.08, -51.77 69.59, 3.54 in-in-out SNCiio in-out ActLoopNT-in 2.8525 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -72.33, -175.56 APE9-dihe-na 154.16, -172.85 APE8-dihe-in -105.14, 130.27 APE8-rot-in 300.55 APE67-dihe-in -61.64, -28.91 -51.09, -46.77 APE12-dist-in 11.85 APE11-dist-out 7.4022 APE10-dist-in 6.0202 APE9-dist-in 3.3421 L294F None None XRAY 2.0 0.171 0.191 B 304.0 282.0 13 33 23 10 [[18, 292]] 1.0 5ng0 TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5AR3A O43353 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.9241 14.2881 BLAminus -133.03, 175.56 72.21, 76.24 -97.68, 34.32 293.9, 86.68 -66.76, -37.47 in-in in 7.9943 Saltbr-in 2.7998 HRD-in -61.0, -40.82 51.84, 8.75 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -117.65 APE9-dihe-na 164.28, -57.84 APE8-dihe-in -114.77, 107.38 APE8-rot-out 185.6 APE67-dihe-in -64.24, -32.65 -95.4, 6.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.7091 APE9-dist-out 10.828 None None None XRAY 3.23 0.192 0.254 A 326.0 279.0 26 33 19 14 [[18, 292]] 1.0 5ar3 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5AR3B O43353 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.8705 14.4182 BLAminus -128.31, 176.09 65.92, 78.1 -98.91, 35.33 294.64, 70.55 -68.55, -48.71 in-in in 8.021 Saltbr-in 2.8795 HRD-in -65.19, -46.65 55.58, 8.54 in-in-out SNCiio in-out ActLoopNT-in 2.8614 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.98 APE8-rot-out 49.06 APE67-dihe-in -39.82, -41.25 -97.08, -7.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.23 0.192 0.254 B 326.0 276.0 29 33 17 16 [[18, 292]] 1.0 5ar3 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 AF-O43353-K1A O43353 10 300 540.0 No_ligand No_ligand Inactive DFGin 5.8465 14.0078 BLAminus -127.94, 175.85 61.05, 79.69 -94.57, 16.88 285.86, 79.13 -59.24, -35.38 in-in in 8.056 Saltbr-in 2.7289 HRD-in -78.75, -47.93 64.43, -6.6 in-in-out SNCiio in-out ActLoopNT-in 2.8926 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -61.43, 170.33 APE9-dihe-na 162.37, 176.49 APE8-dihe-in -85.18, 118.94 APE8-rot-in 304.26 APE67-dihe-in -60.83, -35.85 -43.4, -45.78 APE12-dist-in 11.8663 APE11-dist-out 7.5907 APE10-dist-in 6.5108 APE9-dist-in 3.4941 None None None AF2 -1.0 1.0 1.0 A 291.0 291.0 0 33 33 0 [[18, 292]] 1.0 AF-O43353-K1 TKL_RIPK2_HUMAN TKL 3.5e-73 252.3 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 8AZAA O43353 8 314 540.0 No_ligand No_ligand Inactive DFGin 6.638 14.9717 BLAminus -149.95, -164.59 59.67, 64.47 -87.13, 14.1 289.04, 7.53 -62.24, -46.57 in-out in 9.7382 Saltbr-out 8.8925 HRD-in -64.59, -39.64 71.24, -10.99 out-in-out SNCoio in-out ActLoopNT-in 3.2457 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.84 APE8-rot-out 77.29 APE67-dihe-in -86.62, -6.01 -67.77, -11.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.15 999.0 999.0 A 317.0 284.0 23 33 20 13 [[18, 292]] 1.0 8aza TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 8AZAB O43353 8 314 540.0 No_ligand No_ligand Inactive DFGin 5.3355 13.5513 BLAminus -130.42, -164.95 50.89, 68.36 -81.01, 15.64 291.47, 76.47 -59.33, -43.28 in-out in 7.362 Saltbr-out 5.6055 HRD-in -91.72, -62.3 59.19, 5.81 out-in-none SNCoin in-none ActLoopNT-in 3.4609 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.15 999.0 999.0 B 317.0 246.0 61 33 8 25 [[18, 292]] 1.0 8aza TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5AR2A O43353 4 310 540.0 No_ligand No_ligand Inactive DFGin 5.9315 14.5204 BLAminus -127.38, -176.39 62.31, 78.66 -95.92, 24.69 288.34, 80.55 -59.09, -44.11 in-in in 8.4919 Saltbr-in 2.871 HRD-in -75.18, -53.25 68.8, 7.8 in-in-out SNCiio in-out ActLoopNT-in 2.7969 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 116.83 APE9-dihe-na -174.85, -153.32 APE8-dihe-in -65.24, 140.18 APE8-rot-out 190.57 APE67-dihe-in -65.15, -22.55 -115.33, 6.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.3853 APE9-dist-out 10.606 None None None XRAY 2.44 0.172 0.211 A 326.0 277.0 30 33 19 14 [[18, 292]] 1.0 5ar2 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5AR2B O43353 4 310 540.0 No_ligand No_ligand Inactive DFGin 6.0514 14.5222 BLAminus -121.7, 177.66 61.53, 80.64 -98.26, 20.96 286.82, 74.03 -54.66, -35.04 in-in in 8.4347 Saltbr-in 3.4795 HRD-in -73.03, -54.01 65.44, 6.7 in-in-out SNCiio in-out ActLoopNT-in 2.8619 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -62.83, 130.3 APE9-dihe-na -160.33, 164.95 APE8-dihe-in -67.1, 149.78 APE8-rot-out 186.39 APE67-dihe-in -54.03, -24.23 -110.46, -3.23 APE12-dist-in 11.9721 APE11-dist-in 9.9909 APE10-dist-out 13.0438 APE9-dist-out 10.6303 None None None XRAY 2.44 0.172 0.211 B 326.0 285.0 22 33 22 11 [[18, 292]] 1.0 5ar2 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OA O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1363 13.9064 BLAminus -125.19, -174.64 59.09, 81.1 -106.86, 24.62 291.19, 85.74 -72.37, -32.43 in-none in 7.781 Saltbr-none 999.0 HRD-in -58.73, -48.93 54.24, 22.59 none-in-out SNCnio in-out ActLoopNT-in 2.7789 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 52.01 APE8-dihe-in -88.74, 126.44 APE8-rot-out 182.28 APE67-dihe-in -69.67, -13.84 -102.91, 3.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7802 None None None XRAY 2.89 0.219 0.252 A 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OB O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.075 13.8552 BLAminus -124.69, -174.05 60.01, 82.18 -107.5, 25.35 291.09, 85.35 -69.3, -34.49 in-none in 7.852 Saltbr-none 999.0 HRD-in -59.53, -49.22 54.97, 22.29 none-in-out SNCnio in-out ActLoopNT-in 2.7955 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.07 APE8-dihe-in -82.18, 127.67 APE8-rot-out 181.47 APE67-dihe-in -70.21, -14.17 -102.49, 4.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7893 None None None XRAY 2.89 0.219 0.252 B 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OC O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 5.9407 13.8497 BLAminus -124.15, -173.26 59.49, 81.39 -107.32, 24.78 291.29, 84.01 -68.0, -35.39 in-none in 7.8877 Saltbr-none 999.0 HRD-in -61.12, -47.92 53.98, 21.23 none-in-out SNCnio in-out ActLoopNT-in 2.7891 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 58.39 APE8-dihe-in -87.67, 127.44 APE8-rot-out 182.78 APE67-dihe-in -69.34, -14.96 -102.25, 3.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4354 None None None XRAY 2.89 0.219 0.252 C 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OD O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1004 13.7601 BLAminus -124.11, -174.9 59.11, 83.61 -107.83, 24.21 291.26, 84.74 -71.93, -33.31 in-none in 7.7124 Saltbr-none 999.0 HRD-in -58.77, -50.37 55.05, 21.57 none-in-out SNCnio in-out ActLoopNT-in 2.7974 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 52.34 APE8-dihe-in -81.49, 128.95 APE8-rot-out 42.92 APE67-dihe-in -70.09, -15.04 -103.55, 3.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6555 None None None XRAY 2.89 0.219 0.252 D 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OE O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1549 13.9143 BLAminus -125.32, -175.39 59.04, 81.44 -106.24, 24.21 291.63, 86.05 -73.47, -30.79 in-in in 7.8417 Saltbr-in 2.7712 HRD-in -59.5, -48.44 53.52, 22.49 in-in-out SNCiio in-out ActLoopNT-in 2.7698 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 63.28 APE8-dihe-in -87.25, 127.57 APE8-rot-out 182.11 APE67-dihe-in -69.71, -14.84 -102.46, 3.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9221 None None None XRAY 2.89 0.219 0.252 E 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OF O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1021 13.7845 BLAminus -125.28, -174.81 60.87, 81.57 -107.6, 24.8 291.53, 85.38 -69.89, -33.64 in-none in 7.7824 Saltbr-none 999.0 HRD-in -59.66, -48.54 55.22, 21.96 none-in-out SNCnio in-out ActLoopNT-in 2.7916 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 60.19 APE8-dihe-in -79.96, 131.01 APE8-rot-out 181.63 APE67-dihe-in -71.08, -14.3 -102.18, 4.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6497 None None None XRAY 2.89 0.219 0.252 F 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OG O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.0863 13.8448 BLAminus -124.86, -174.91 60.12, 81.59 -107.81, 23.84 291.29, 84.93 -68.89, -36.67 in-none in 7.7335 Saltbr-none 999.0 HRD-in -64.82, -49.86 54.77, 20.73 none-in-out SNCnio in-out ActLoopNT-in 2.7872 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 60.09 APE8-dihe-in -78.03, 125.79 APE8-rot-out 184.52 APE67-dihe-in -69.81, -14.62 -102.95, 4.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7849 None None None XRAY 2.89 0.219 0.252 G 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OH O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.0893 13.938 BLAminus -123.39, -173.38 58.61, 81.33 -105.97, 24.15 291.79, 83.79 -68.5, -35.98 in-in in 7.8994 Saltbr-in 2.7036 HRD-in -60.4, -48.42 54.87, 21.93 in-in-out SNCiio in-out ActLoopNT-in 2.7873 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -55.03 APE8-dihe-in -80.95, 128.93 APE8-rot-out 42.89 APE67-dihe-in -69.91, -14.59 -102.1, 3.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4271 None None None XRAY 2.89 0.219 0.252 H 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OI O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 5.9459 13.8868 BLAminus -123.53, -172.96 57.44, 81.36 -106.55, 24.49 290.99, 84.39 -68.01, -35.42 in-none in 7.8441 Saltbr-none 999.0 HRD-in -60.65, -52.84 62.49, 6.67 none-in-out SNCnio in-out ActLoopNT-in 2.7926 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -155.66 APE8-dihe-in -115.79, 147.83 APE8-rot-out 226.21 APE67-dihe-in -65.02, -15.65 -101.34, 1.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.4171 None None None XRAY 2.89 0.219 0.252 I 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OJ O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1261 13.8532 BLAminus -125.49, -173.66 60.26, 80.69 -107.0, 24.2 291.57, 84.27 -70.16, -35.59 in-in in 7.7874 Saltbr-in 2.7609 HRD-in -59.56, -49.0 54.34, 21.8 in-in-out SNCiio in-out ActLoopNT-in 2.8093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 62.31 APE8-dihe-in -78.64, 127.4 APE8-rot-out 183.39 APE67-dihe-in -70.3, -14.88 -101.54, 2.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.595 None None None XRAY 2.89 0.219 0.252 J 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OK O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1293 13.8059 BLAminus -123.47, -174.04 59.2, 82.79 -107.55, 23.57 291.68, 84.11 -72.29, -31.81 in-in in 7.7765 Saltbr-in 2.8227 HRD-in -59.03, -50.17 55.62, 20.99 in-in-out SNCiio in-out ActLoopNT-in 2.7932 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 54.61 APE8-dihe-in -86.36, 126.77 APE8-rot-out 185.25 APE67-dihe-in -70.21, -14.67 -104.03, 4.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9333 None None None XRAY 2.89 0.219 0.252 K 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OL O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 5.9768 13.8724 BLAminus -123.97, -173.69 59.22, 81.96 -107.43, 24.71 291.89, 82.85 -67.15, -36.07 in-in in 7.9099 Saltbr-in 2.7447 HRD-in -60.31, -48.17 54.61, 21.38 in-in-out SNCiio in-out ActLoopNT-in 2.7921 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 61.72 APE8-dihe-in -85.16, 131.31 APE8-rot-out 40.96 APE67-dihe-in -60.1, -15.62 -98.81, -9.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3911 None None None XRAY 2.89 0.219 0.252 L 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OM O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1064 13.8754 BLAminus -124.12, -175.41 59.62, 81.55 -107.4, 24.65 291.81, 83.79 -71.72, -32.48 in-none in 7.7974 Saltbr-none 999.0 HRD-in -58.16, -49.42 54.05, 21.71 none-in-out SNCnio in-out ActLoopNT-in 2.7926 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 41.26 APE8-dihe-in -78.53, 134.02 APE8-rot-out 36.01 APE67-dihe-in -69.76, -14.56 -101.27, 4.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.0598 None None None XRAY 2.89 0.219 0.252 M 310.0 276.0 30 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5ON O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.0791 13.9277 BLAminus -124.88, -172.7 59.14, 81.77 -106.98, 23.8 291.97, 82.42 -69.42, -34.18 in-none in 7.9469 Saltbr-none 999.0 HRD-in -59.84, -48.61 54.69, 21.04 none-in-out SNCnio in-out ActLoopNT-in 2.7885 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 57.95 APE8-dihe-in -84.02, 128.93 APE8-rot-out 182.08 APE67-dihe-in -69.96, -13.84 -103.42, 3.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6515 None None None XRAY 2.89 0.219 0.252 N 310.0 272.0 34 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OO O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1838 13.8237 BLAminus -123.94, -174.15 58.85, 81.43 -106.41, 23.33 291.99, 84.7 -71.56, -32.06 in-in in 7.7913 Saltbr-in 2.7914 HRD-in -58.13, -49.83 54.51, 21.43 in-in-out SNCiio in-out ActLoopNT-in 2.7873 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 64.54 APE8-dihe-in -77.78, 132.07 APE8-rot-out 38.52 APE67-dihe-in -70.42, -14.07 -103.31, 4.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3895 None None None XRAY 2.89 0.219 0.252 O 310.0 276.0 30 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5OP O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.0245 13.8318 BLAminus -124.74, -174.78 59.93, 81.7 -106.98, 23.2 291.86, 82.87 -68.58, -34.35 in-none in 7.9853 Saltbr-none 999.0 HRD-in -60.06, -48.48 54.27, 16.98 none-in-out SNCnio in-out ActLoopNT-in 2.7918 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 52.76 APE8-dihe-in -83.36, 127.8 APE8-rot-out 182.51 APE67-dihe-in -70.3, -14.79 -101.64, 2.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7436 None None None XRAY 2.89 0.219 0.252 P 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6HMXA O43353 5 310 540.0 GEZ:401 Type1 Inactive DFGin 6.2358 14.3161 BLAminus -124.52, -177.56 66.8, 84.95 -109.14, 29.79 295.83, 94.07 -68.94, -45.49 in-in in 7.794 Saltbr-in 3.2337 HRD-in -58.38, -60.47 64.01, 17.43 in-in-out SNCiio in-out ActLoopNT-in 2.7998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -151.32 APE9-dihe-na -124.57, -125.51 APE8-dihe-in -82.66, 129.77 APE8-rot-out 187.19 APE67-dihe-in -64.93, -22.0 -95.67, -1.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.5562 APE9-dist-out 10.4465 None None None XRAY 2.53 0.166 0.192 A 311.0 280.0 26 33 18 15 [[18, 292]] 1.0 6hmx TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6HMXB O43353 5 310 540.0 GEZ:401 Type1 Inactive DFGin 6.1862 14.368 BLAminus -124.43, -176.46 65.93, 86.3 -112.37, 30.95 293.81, 90.5 -69.1, -47.31 in-in in 7.9189 Saltbr-in 3.1559 HRD-in -59.3, -60.67 66.8, 11.61 in-in-out SNCiio in-out ActLoopNT-in 2.8129 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 165.56 APE9-dihe-na -122.56, -147.83 APE8-dihe-in -59.45, 144.61 APE8-rot-out 192.64 APE67-dihe-in -62.6, -17.14 -111.83, -1.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.6547 APE9-dist-out 11.1676 None None None XRAY 2.53 0.166 0.192 B 311.0 282.0 24 33 19 14 [[18, 292]] 1.0 6hmx TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6SZEB O43353 5 310 540.0 M2B:402 Type1 Inactive DFGin 6.0394 14.5744 BLAminus -129.09, 175.84 70.06, 89.61 -113.49, 18.44 288.29, 86.33 -60.8, -47.17 in-in in 7.885 Saltbr-in 3.1277 HRD-in -75.74, -46.99 56.85, -2.91 in-in-out SNCiio in-out ActLoopNT-in 2.9116 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -136.96, -159.87 APE9-dihe-na -128.34, -119.13 APE8-dihe-in -65.42, 150.34 APE8-rot-out 193.04 APE67-dihe-in -52.67, -15.51 -114.53, -21.66 APE12-dist-none 999.0 APE11-dist-in 12.8399 APE10-dist-out 10.1206 APE9-dist-out 11.0415 None None None XRAY 2.94 0.179 0.234 B 311.0 276.0 30 33 18 15 [[18, 292]] 1.0 6sze TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6SZJB O43353 5 310 540.0 M5W:402 Type1 Inactive DFGin 6.0601 14.8025 BLAminus -127.62, -178.38 64.51, 85.71 -108.62, 30.49 299.07, 85.51 -62.99, -29.31 in-in in 8.0355 Saltbr-in 2.624 HRD-in -73.84, -57.47 64.38, 3.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -111.13, -160.71 APE9-dihe-na -124.86, -125.22 APE8-dihe-in -69.02, 143.41 APE8-rot-out 187.62 APE67-dihe-in -53.68, -19.89 -104.22, -17.47 APE12-dist-none 999.0 APE11-dist-in 13.7473 APE10-dist-out 10.3847 APE9-dist-out 10.9785 None None None XRAY 2.53 0.191 0.241 B 311.0 283.0 23 33 16 17 [[18, 292]] 1.0 6szj TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6FU5A O43353 5 315 540.0 E7N:400 Type1 Inactive DFGin 5.9695 14.1294 BLAminus -149.81, 168.35 73.17, 56.82 -87.36, -24.33 315.9, 145.59 -100.37, 169.03 in-in in 8.1619 Saltbr-in 2.9851 HRD-in -66.01, -55.94 58.15, 19.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -113.83 APE8-dihe-out -84.15, 2.15 APE8-rot-out 169.53 APE67-dihe-in -57.24, -36.43 -90.25, -17.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2691 None None None XRAY 3.26 0.231 0.271 A 317.0 282.0 29 33 13 20 [[18, 292]] 1.0 6fu5 TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6S1FB O43353 5 315 540.0 KRE:400 Type1 Inactive DFGin 6.0889 14.5519 BLAminus -136.13, -177.6 64.6, 77.45 -102.32, 33.61 287.44, 99.54 -74.42, -24.82 in-out in 8.5067 Saltbr-out 4.3325 HRD-in -68.09, -52.63 66.62, 10.13 out-in-out SNCoio in-out ActLoopNT-in 2.922 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -76.64 APE8-rot-out 48.4 APE67-dihe-in -60.75, -18.88 -96.32, -3.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.11 0.256 0.3 B 317.0 286.0 25 33 19 14 [[18, 292]] 1.0 6s1f TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6S1FD O43353 5 316 540.0 KRE:400 Type1 Inactive DFGin 5.7543 14.4945 BLAminus -135.97, -176.52 66.84, 77.7 -101.6, 58.1 285.65, 99.66 -72.67, -42.59 in-in in 8.2322 Saltbr-in 3.111 HRD-in -68.66, -53.79 68.01, 9.06 in-in-out SNCiio in-out ActLoopNT-in 3.5614 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -44.09 APE8-dihe-out -55.97, -26.25 APE8-rot-out 47.91 APE67-dihe-in -63.85, -22.41 -93.96, -4.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6285 None None None XRAY 3.11 0.256 0.3 D 317.0 288.0 24 33 16 17 [[18, 292]] 1.0 6s1f TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5AR5A O43353 4 310 540.0 IQ7:1312 Type1 Inactive DFGin 6.0809 13.9195 BLAminus -126.86, 179.69 62.84, 81.27 -103.15, 21.11 292.75, 77.76 -56.66, -44.59 in-in in 8.1036 Saltbr-in 2.8225 HRD-in -78.11, -46.09 56.4, 9.14 in-in-out SNCiio in-out ActLoopNT-in 2.806 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -92.65, 115.03 APE9-dihe-na -137.7, -171.82 APE8-dihe-in -72.24, 155.44 APE8-rot-out 54.69 APE67-dihe-in -55.38, -21.99 -110.33, -4.36 APE12-dist-none 999.0 APE11-dist-in 8.3611 APE10-dist-out 12.0932 APE9-dist-out 10.5038 None None None XRAY 2.66 0.172 0.217 A 326.0 284.0 23 33 20 13 [[18, 292]] 1.0 5ar5 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5AR5B O43353 4 310 540.0 IQ7:1311 Type1 Inactive DFGin 6.0569 14.2413 BLAminus -142.51, -179.66 67.74, 82.82 -106.87, 40.76 298.14, 96.55 -73.01, -50.49 in-in in 8.0366 Saltbr-in 2.7608 HRD-in -72.89, -56.07 62.45, 7.8 in-in-out SNCiio in-out ActLoopNT-in 2.8285 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 150.41 APE8-rot-out 179.27 APE67-dihe-in -68.25, -17.91 -122.83, 8.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.66 0.172 0.217 B 326.0 279.0 28 33 16 17 [[18, 292]] 1.0 5ar5 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5J79A O43353 2 310 540.0 6GE:401 Type1 Inactive DFGin 6.1907 14.8884 BLAminus -120.64, -169.71 53.95, 72.95 -94.42, 19.46 286.13, 70.88 -56.87, -46.79 in-in in 8.0121 Saltbr-in 2.8261 HRD-in -78.08, -43.76 61.31, -5.39 in-in-out SNCiio in-out ActLoopNT-in 2.8429 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -79.71, 177.31 APE9-dihe-na 153.91, -173.6 APE8-dihe-in -106.59, 127.13 APE8-rot-in 297.35 APE67-dihe-in -52.69, -23.77 -40.38, -60.16 APE12-dist-in 12.2053 APE11-dist-out 7.74 APE10-dist-in 6.1582 APE9-dist-in 3.5204 None None None XRAY 2.69 0.164 0.219 A 326.0 283.0 26 33 23 10 [[18, 292]] 1.0 5j79 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5J79B O43353 5 310 540.0 6GE:401 Type1 Inactive DFGin 6.2146 14.6915 BLAminus -127.38, -171.48 58.91, 71.21 -93.63, 17.06 288.17, 81.6 -55.96, -36.73 in-in in 7.8932 Saltbr-in 2.8213 HRD-in -66.88, -48.06 57.22, 15.22 in-in-out SNCiio in-out ActLoopNT-in 2.8949 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -149.85 APE8-dihe-in -92.95, 137.0 APE8-rot-out 192.1 APE67-dihe-in -64.77, -22.33 -110.03, 6.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1187 None None None XRAY 2.69 0.164 0.219 B 326.0 277.0 29 33 18 15 [[18, 292]] 1.0 5j79 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5NG2A O43353 5 298 540.0 STU:401 Type1 Inactive DFGin 5.9592 13.8755 BLAminus -127.83, 178.19 61.49, 80.49 -96.67, 24.09 288.33, 78.8 -62.82, -31.8 in-in in 8.0911 Saltbr-in 2.9024 HRD-in -73.87, -50.37 57.71, 19.44 in-in-out SNCiio in-out ActLoopNT-in 2.8273 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 149.89 APE8-dihe-in -77.86, 146.25 APE8-rot-out 189.94 APE67-dihe-in -66.59, -20.81 -105.1, 1.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8555 D146N None None XRAY 2.8 0.209 0.226 A 304.0 274.0 20 33 19 14 [[18, 292]] 1.0 5ng2 TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5NG2B O43353 5 298 540.0 STU:401 Type1 Inactive DFGin 5.987 13.9001 BLAminus -127.96, 178.42 61.45, 80.21 -96.5, 23.45 288.92, 78.23 -62.02, -31.71 in-in in 8.0927 Saltbr-in 2.8937 HRD-in -73.84, -50.5 58.4, 18.77 in-in-out SNCiio in-out ActLoopNT-in 2.8272 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.58 APE8-dihe-in -77.44, 145.88 APE8-rot-out 189.53 APE67-dihe-in -67.7, -20.58 -104.84, 1.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7903 D146N None None XRAY 2.8 0.209 0.226 B 304.0 278.0 16 33 18 15 [[18, 292]] 1.0 5ng2 TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6UL8A O43353 5 310 540.0 Q9J:401 Type1.5_Back Inactive DFGin 6.0845 13.9036 BLAminus -138.68, 177.39 65.76, 84.99 -107.51, 38.57 290.05, 69.88 -77.69, -36.11 in-in in 7.9595 Saltbr-in 3.1856 HRD-in -69.43, -53.26 62.34, 12.17 in-in-out SNCiio in-out ActLoopNT-in 2.9522 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -165.87 APE8-dihe-in -60.17, 149.46 APE8-rot-out 196.86 APE67-dihe-in -58.24, -30.16 -112.68, 2.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5384 C7S,S168C None None XRAY 2.68 0.185 0.22 A 306.0 279.0 27 33 16 17 [[18, 292]] 1.0 6ul8 TKL_RIPK2_HUMAN TKL 1.9e-72 250.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6UL8B O43353 5 310 540.0 Q9J:402 Type1.5_Back Inactive DFGin 6.1752 13.9804 BLAminus -122.99, -178.46 65.81, 77.15 -98.02, 36.9 291.09, 78.99 -72.1, -29.98 in-in in 8.057 Saltbr-in 3.0831 HRD-in -78.67, -48.07 63.33, 13.97 in-in-out SNCiio in-out ActLoopNT-in 2.7016 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -175.3 APE8-dihe-in -93.82, 150.28 APE8-rot-out 194.98 APE67-dihe-in -68.22, -20.36 -108.06, 1.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4783 C7S,S168C None None XRAY 2.68 0.185 0.22 B 306.0 283.0 23 33 16 17 [[18, 292]] 1.0 6ul8 TKL_RIPK2_HUMAN TKL 1.9e-72 250.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6RN8A O43353 5 310 540.0 K9T:401 Type1.5_Back Inactive DFGin 6.0981 13.8907 BLAminus -121.2, -174.58 53.58, 84.93 -101.75, 30.28 282.16, 80.1 -71.87, -31.63 in-in in 7.9813 Saltbr-in 2.8706 HRD-in -66.39, -50.33 64.83, 11.58 in-in-out SNCiio in-out ActLoopNT-in 2.8624 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.27 APE8-dihe-in -62.06, 149.59 APE8-rot-out 197.55 APE67-dihe-in -63.99, -18.48 -118.03, -0.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6245 None None None XRAY 2.69 0.178 0.212 A 311.0 281.0 25 33 18 15 [[18, 292]] 1.0 6rn8 TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6RN8B O43353 5 310 540.0 K9T:402 Type1.5_Back Inactive DFGin 6.0131 13.7399 BLAminus -122.39, -174.33 51.92, 85.84 -100.82, 20.49 283.98, 79.06 -64.39, -29.28 in-in in 8.2166 Saltbr-in 2.9524 HRD-in -60.94, -56.67 69.44, 9.97 in-in-out SNCiio in-out ActLoopNT-in 2.8249 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -139.63, -164.48 APE9-dihe-na -115.85, -133.91 APE8-dihe-in -56.11, 149.92 APE8-rot-out 199.64 APE67-dihe-in -63.61, -17.82 -118.75, -0.13 APE12-dist-none 999.0 APE11-dist-in 13.3049 APE10-dist-out 10.53 APE9-dist-out 10.9757 None None None XRAY 2.69 0.178 0.212 B 311.0 284.0 22 33 20 13 [[18, 292]] 1.0 6rn8 TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6RNAA O43353 5 310 540.0 KA2:401 Type1.5_Back Inactive DFGin 6.0963 14.1187 BLAminus -118.69, -178.94 59.47, 86.33 -104.16, 26.83 288.87, 81.14 -69.66, -36.26 in-in in 8.0213 Saltbr-in 2.8713 HRD-in -59.8, -53.12 61.06, 18.18 in-in-out SNCiio in-out ActLoopNT-in 2.806 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -150.26 APE9-dihe-na -111.81, -125.99 APE8-dihe-in -71.22, 149.14 APE8-rot-out 191.73 APE67-dihe-in -63.27, -18.82 -116.66, -2.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.3587 APE9-dist-out 10.6079 None None None XRAY 2.62 0.162 0.19 A 311.0 277.0 29 33 19 14 [[18, 292]] 1.0 6rna TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6RNAB O43353 4 310 540.0 KA2:401 Type1.5_Back Inactive DFGin 6.0802 14.2468 BLAminus -120.18, -176.72 60.07, 86.2 -105.54, 23.51 290.08, 82.68 -62.84, -38.47 in-in in 8.0698 Saltbr-in 3.2503 HRD-in -61.33, -52.71 61.11, 15.17 in-in-out SNCiio in-out ActLoopNT-in 2.8167 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -137.02, 170.76 APE9-dihe-na -116.32, -128.61 APE8-dihe-in -67.14, 150.22 APE8-rot-out 193.81 APE67-dihe-in -62.73, -17.87 -118.35, -1.43 APE12-dist-none 999.0 APE11-dist-in 11.9097 APE10-dist-out 10.6231 APE9-dist-out 11.1029 None None None XRAY 2.62 0.162 0.19 B 311.0 284.0 23 33 20 13 [[18, 292]] 1.0 6rna TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 8X2OA O43353 8 316 540.0 6IL:401 Type1.5_Back Inactive DFGin 6.1082 14.063 BLAminus -124.76, -178.24 59.51, 83.58 -103.26, 21.59 286.78, 67.68 -61.63, -25.69 in-in in 8.1719 Saltbr-in 2.8992 HRD-in -73.25, -53.73 66.65, 12.78 in-in-out SNCiio in-out ActLoopNT-in 2.8222 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -34.29 APE8-dihe-out -78.32, -9.99 APE8-rot-none 999.0 APE67-dihe-in -62.03, -22.4 -97.2, -12.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7076 None None None XRAY 2.26 0.215 0.254 A 316.0 278.0 31 33 17 16 [[18, 292]] 1.0 8x2o TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 8X2OB O43353 9 316 540.0 6IL:401 Type1.5_Back Inactive DFGin 5.9557 14.0215 BLAminus -124.91, 179.9 57.85, 85.82 -101.47, 22.95 284.79, 67.03 -59.39, -22.8 in-in in 8.2288 Saltbr-in 2.7018 HRD-in -76.1, -54.35 62.81, 14.76 in-in-out SNCiio in-out ActLoopNT-in 2.6809 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.95 APE8-dihe-out -77.16, -10.52 APE8-rot-out 66.48 APE67-dihe-in -64.46, -19.1 -99.04, -14.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1454 None None None XRAY 2.26 0.215 0.254 B 316.0 287.0 21 33 17 16 [[18, 292]] 1.0 8x2o TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6S1FA O43353 5 316 540.0 KRE:400 Type1 Inactive DFGin 5.8865 14.1537 BLBminus -136.68, -174.64 68.69, 76.96 -104.64, -172.79 287.96, 1.48 75.58, -141.77 in-in in 7.9208 Saltbr-in 2.8937 HRD-in -68.42, -54.93 68.33, 10.57 in-out-out SNCioo out-out ActLoopNT-out 14.855 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -44.24 APE8-dihe-out -97.88, 11.31 APE8-rot-out 48.21 APE67-dihe-in -64.33, -18.5 -93.61, -4.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.7127 None None None XRAY 3.11 0.256 0.3 A 317.0 291.0 21 33 17 16 [[18, 292]] 1.0 6s1f TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6S1FC O43353 5 315 540.0 KRE:400 Type1 Inactive DFGin 6.4178 14.4655 BLBminus -136.0, -178.34 66.52, 77.3 -105.6, -150.08 288.38, 1.24 54.26, -143.32 in-in in 8.103 Saltbr-in 3.2949 HRD-in -66.98, -53.6 67.88, 10.57 in-out-out SNCioo out-out ActLoopNT-out 14.6769 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -39.08 APE8-dihe-out -92.13, -29.89 APE8-rot-out 48.51 APE67-dihe-in -60.41, -17.19 -93.43, -2.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.1049 None None None XRAY 3.11 0.256 0.3 C 317.0 289.0 22 33 17 16 [[18, 292]] 1.0 6s1f TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5AR8B O43353 8 310 540.0 XYW:1311 Type1.5_Back Inactive DFGin 6.4448 14.5481 BLBminus -138.31, -177.12 57.02, 46.97 -53.35, 139.38 296.36, 78.76 -77.07, 61.56 out-out out 11.7203 Saltbr-out 9.6727 HRD-in -73.74, -57.92 63.65, 13.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 6.02 APE9-dihe-na -70.75, 168.46 APE8-dihe-in -59.78, 148.4 APE8-rot-out 194.81 APE67-dihe-in -57.35, -6.9 -103.85, -13.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.4251 APE9-dist-out 10.6323 None None None XRAY 2.79 0.204 0.233 B 326.0 274.0 29 33 14 19 [[18, 292]] 1.0 5ar8 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5NG3A O43353 8 297 540.0 No_ligand No_ligand Inactive DFGin 5.5395 12.8991 BLBplus -112.38, 160.58 70.97, 23.75 -68.8, 144.03 47.35, 86.99 65.51, 12.2 out-none out 12.7512 Saltbr-none 999.0 HRD-in -71.1, -58.95 67.21, 2.05 none-out-out SNCnoo out-out ActLoopNT-out 9.7889 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -127.51, 155.11 APE9-dihe-na -75.1, 166.99 APE8-dihe-in -61.92, 146.05 APE8-rot-out 193.53 APE67-dihe-in -56.91, -27.84 -109.89, 2.62 APE12-dist-none 999.0 APE11-dist-out 18.3793 APE10-dist-out 14.8698 APE9-dist-out 10.1617 K47R TPO111 TPO111 XRAY 2.6 0.234 0.269 A 304.0 284.0 6 33 27 6 [[18, 292]] 1.0 5ng3 TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5NG3B O43353 9 297 540.0 No_ligand No_ligand Inactive DFGin 5.6695 12.9014 BLBplus -112.34, 160.48 70.49, 24.2 -68.43, 144.17 47.17, 86.84 64.87, 12.81 out-none out 12.9136 Saltbr-none 999.0 HRD-in -70.57, -58.52 66.45, 2.64 none-out-out SNCnoo out-out ActLoopNT-out 9.7093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -51.15 APE9-dihe-na -75.96, 168.48 APE8-dihe-in -61.9, 146.98 APE8-rot-out 192.74 APE67-dihe-in -54.8, -29.64 -109.73, 3.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.1216 APE9-dist-out 9.6412 K47R None None XRAY 2.6 0.234 0.269 B 304.0 275.0 14 33 25 8 [[18, 292]] 1.0 5ng3 TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5NG3C O43353 9 297 540.0 No_ligand No_ligand Inactive DFGin 5.5896 12.944 BLBplus -112.71, 161.13 70.64, 23.93 -68.42, 144.19 47.15, 87.05 64.5, 12.74 out-none out 12.8447 Saltbr-none 999.0 HRD-in -71.02, -58.72 67.3, 1.13 none-out-out SNCnoo out-out ActLoopNT-out 9.8157 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 160.87 APE8-dihe-in -62.18, 147.01 APE8-rot-out 192.72 APE67-dihe-in -54.87, -29.19 -109.49, 3.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.9977 K47R None None XRAY 2.6 0.234 0.269 C 304.0 272.0 17 33 24 9 [[18, 292]] 1.0 5ng3 TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5NG3D O43353 9 297 540.0 No_ligand No_ligand Inactive DFGin 5.5736 12.8886 BLBplus -112.39, 160.12 71.59, 23.49 -69.04, 143.91 48.32, 92.26 67.92, 12.12 out-none out 12.805 Saltbr-none 999.0 HRD-in -69.99, -59.28 66.07, 2.93 none-out-out SNCnoo out-out ActLoopNT-out 9.6277 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -124.38, 144.23 APE9-dihe-na -74.77, 167.56 APE8-dihe-in -63.05, 146.04 APE8-rot-out 193.19 APE67-dihe-in -62.45, -21.47 -111.58, 2.98 APE12-dist-none 999.0 APE11-dist-out 18.2155 APE10-dist-out 15.1103 APE9-dist-out 10.1475 K47R TPO111 TPO111 XRAY 2.6 0.234 0.269 D 304.0 279.0 10 33 27 6 [[18, 292]] 1.0 5ng3 TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6SZEA O43353 5 310 540.0 M2B:401 Type1 Inactive DFGin 4.6852 14.1881 BLBplus -140.38, 176.81 56.22, 39.89 -108.75, 153.17 54.91, 95.34 65.03, 43.78 in-in in 7.7009 Saltbr-in 2.8207 HRD-in -69.61, -60.35 64.99, -5.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 142.75 APE8-rot-out 182.72 APE67-dihe-in -63.71, -17.61 -123.61, 3.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.94 0.179 0.234 A 311.0 274.0 32 33 13 20 [[18, 292]] 1.0 6sze TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6SZJA O43353 5 310 540.0 M5W:401 Type1 Inactive DFGin 4.728 14.5425 BLBplus -128.88, 175.29 56.57, 61.59 -132.22, 139.55 60.02, 89.16 45.92, 68.66 in-in in 7.8419 Saltbr-in 3.596 HRD-in -66.36, -57.71 64.68, 3.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -118.11 APE8-dihe-in -97.65, 128.8 APE8-rot-out 180.19 APE67-dihe-in -65.16, -18.87 -95.83, 0.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.12 None None None XRAY 2.53 0.191 0.241 A 311.0 279.0 27 33 13 20 [[18, 292]] 1.0 6szj TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5AR4A O43353 5 310 540.0 SB2:1311 Type1 Inactive DFGin 4.6318 14.0452 BLBplus -139.45, 166.57 61.79, 49.71 -115.35, 148.15 54.64, 94.62 62.79, 37.41 in-in in 7.6452 Saltbr-in 2.8208 HRD-in -68.8, -62.63 63.67, 2.11 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.58 APE8-rot-out 174.49 APE67-dihe-in -67.48, -22.2 -110.63, -5.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.18 0.216 A 326.0 274.0 32 33 12 21 [[18, 292]] 1.0 5ar4 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5AR4B O43353 6 310 540.0 SB2:1311 Type1 Inactive DFGin 4.569 14.0575 BLBplus -133.48, 172.27 57.95, 41.37 -105.11, 150.43 49.24, 89.44 68.18, 19.95 in-in in 7.5793 Saltbr-in 2.9036 HRD-in -72.79, -67.06 71.53, 1.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.45 APE8-dihe-in -96.06, 114.48 APE8-rot-out 179.92 APE67-dihe-in -54.67, -24.97 -78.06, -12.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3315 None None None XRAY 2.7 0.18 0.216 B 326.0 279.0 26 33 13 20 [[18, 292]] 1.0 5ar4 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5J7BA O43353 5 310 540.0 6GD:401 Type1 Inactive DFGin 4.5876 14.4045 BLBplus -129.48, 168.3 62.65, 43.46 -109.82, 148.85 51.68, 86.16 70.79, 38.23 in-in in 7.8674 Saltbr-in 2.8886 HRD-in -71.32, -62.27 67.57, -0.37 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -116.74 APE8-dihe-in -88.25, 140.13 APE8-rot-out 180.7 APE67-dihe-in -66.48, -20.9 -107.99, 7.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.229 None None None XRAY 2.53 0.182 0.233 A 326.0 277.0 29 33 13 20 [[18, 292]] 1.0 5j7b TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5J7BB O43353 4 310 540.0 6GD:401 Type1 Inactive DFGin 4.6349 14.6096 BLBplus -120.37, 168.05 63.64, 41.51 -106.03, 152.65 50.14, 87.53 73.72, 5.94 in-in in 7.9759 Saltbr-in 2.7682 HRD-in -76.48, -65.75 71.16, -2.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -95.83, 157.85 APE9-dihe-na -91.06, -150.2 APE8-dihe-in -80.84, 153.57 APE8-rot-out 185.33 APE67-dihe-in -54.63, -17.55 -109.62, -19.05 APE12-dist-none 999.0 APE11-dist-out 16.3249 APE10-dist-out 13.7217 APE9-dist-out 10.4684 None None None XRAY 2.53 0.182 0.233 B 326.0 281.0 26 33 15 18 [[18, 292]] 1.0 5j7b TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5JA O43353 9 310 540.0 9WS:401 Type1 Inactive DFGin 6.0636 11.774 None -119.1, 58.24 -81.72, 48.17 -169.21, 999.0 29.16, 78.79 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-out -76.29, 33.51 -93.6, 157.22 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.86 APE8-rot-out 51.78 APE67-dihe-in -59.34, -25.23 -55.53, -13.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.22 0.268 A 310.0 251.0 51 33 10 23 [[18, 292]] 1.0 5w5j TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5W5JB O43353 10 311 540.0 9WS:401 Type1 Inactive DFGin 10.6638 12.427 None -117.65, 82.68 -113.99, 168.64 -106.24, 999.0 178.58, 75.53 999.0, 999.0 out-none out 12.7338 Saltbr-none 999.0 HRD-none 999.0, -168.86 -106.07, -61.78 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.02 APE8-rot-out 182.83 APE67-dihe-in -59.02, -25.25 -78.75, -12.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.22 0.268 B 310.0 257.0 45 33 10 23 [[18, 292]] 1.0 5w5j TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6FU5B O43353 5 316 540.0 E7N:400 Type1 Inactive DFGin 5.9966 14.4823 None -152.27, 168.89 72.98, 59.18 -85.18, 999.0 313.99, 145.21 999.0, 999.0 in-in in 8.2541 Saltbr-in 3.2918 HRD-in -67.82, -57.29 58.73, 20.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 33.08 APE8-dihe-out -121.2, 5.37 APE8-rot-out 45.9 APE67-dihe-in -54.25, -32.94 -85.9, -14.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.8037 None None None XRAY 3.26 0.231 0.271 B 317.0 286.0 26 33 11 22 [[18, 292]] 1.0 6fu5 TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 9F3VA O43353 9 314 540.0 A1H90:401 Type1 Inactive DFGin 6.1196 11.6318 None -123.15, 40.28 -90.71, 70.0 -87.39, 999.0 300.2, 126.34 999.0, 999.0 out-out out 12.4585 Saltbr-out 11.3915 HRD-out -117.23, 144.8 -142.51, 123.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.92 APE8-rot-out 194.2 APE67-dihe-in -71.3, -18.73 -128.19, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.943 0.222 0.256 A 320.0 271.0 35 33 10 23 [[18, 292]] 1.0 9f3v TKL_RIPK2_HUMAN TKL 5e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 9F3VB O43353 9 315 540.0 A1H90:401 Type1 Inactive DFGin 6.1588 11.1837 None -124.64, 37.34 -86.49, 73.07 -88.12, -171.81 302.83, 123.42 -66.33, -25.78 out-out out 11.9434 Saltbr-out 13.034 HRD-out -117.06, 146.57 -143.26, 122.43 out-out-out SNCooo out-out ActLoopNT-out 9.0527 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.32 APE8-rot-out 190.74 APE67-dihe-in -70.4, -21.68 -126.9, 0.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.943 0.222 0.256 B 320.0 278.0 29 33 15 18 [[18, 292]] 1.0 9f3v TKL_RIPK2_HUMAN TKL 5e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5AR8A O43353 9 310 540.0 XYW:1311 Type1.5_Back Inactive DFGin 6.4925 13.7371 None -145.13, 172.75 65.95, 57.21 -55.82, 999.0 299.0, 99.97 999.0, 999.0 out-out out 11.8351 Saltbr-out 10.7188 HRD-in -72.15, -51.23 60.29, 11.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -41.34 APE8-dihe-in -100.17, 152.95 APE8-rot-out 191.99 APE67-dihe-in -63.35, -16.88 -126.62, -2.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0407 None None None XRAY 2.79 0.204 0.233 A 326.0 255.0 47 33 11 22 [[18, 292]] 1.0 5ar8 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6ES0A O43353 5 316 540.0 BW8:401 Type2 Inactive DFGout 14.1211 8.9233 BBAminus -138.52, -178.62 -150.57, 111.81 -84.27, -8.2 285.77, 101.08 -70.34, 157.2 in-in in 8.2327 Saltbr-in 2.7817 HRD-in -75.11, -58.32 62.84, 20.2 in-out-out SNCioo out-out ActLoopNT-out 10.2709 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -68.98 APE8-dihe-out -81.68, 11.21 APE8-rot-out 56.58 APE67-dihe-in -75.1, -13.25 -106.14, -1.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.3743 None None None XRAY 2.38 0.216 0.258 A 317.0 288.0 24 33 16 17 [[18, 292]] 1.0 6es0 TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 6ES0B O43353 5 315 540.0 BW8:401 Type2 Inactive DFGout 14.0432 9.0664 BBAminus -137.57, -177.15 -156.56, 109.76 -81.72, 4.5 291.34, 90.75 -64.05, 168.24 in-in in 8.6494 Saltbr-in 2.8001 HRD-in -85.89, -59.6 64.07, 17.46 in-out-out SNCioo out-out ActLoopNT-out 10.8379 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.42 APE8-dihe-in -71.95, 155.63 APE8-rot-out 184.48 APE67-dihe-in -73.42, -23.5 -115.93, 5.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.1118 None None None XRAY 2.38 0.216 0.258 B 317.0 287.0 24 33 17 16 [[18, 292]] 1.0 6es0 TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5AR7B O43353 6 310 540.0 SR8:1311 Type2 Inactive DFGout 14.1236 8.7475 BBAminus -122.07, 179.23 -147.51, 96.13 -66.21, -16.47 275.32, 92.13 58.18, 999.0 in-in in 7.8442 Saltbr-in 2.8175 HRD-in -67.02, -63.9 68.7, 14.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -175.85 APE8-dihe-in -67.25, 147.17 APE8-rot-out 32.44 APE67-dihe-in -57.24, -19.17 -103.63, -6.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.709 None None None XRAY 2.71 0.184 0.225 B 326.0 279.0 26 33 12 21 [[18, 292]] 1.0 5ar7 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 4C8BA O43353 8 316 540.0 0LI:1000 Type2 Inactive DFGout 12.7285 8.5841 None -142.99, -175.55 -154.35, 140.4 -129.56, 999.0 290.55, 114.67 999.0, 999.0 in-in in 8.2431 Saltbr-in 2.8173 HRD-in -79.84, -58.2 64.89, 19.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.9 APE8-dihe-out -84.71, -55.98 APE8-rot-none 999.0 APE67-dihe-in -64.98, -25.64 -68.13, -16.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2944 None None None XRAY 2.75 0.203 0.244 A 334.0 279.0 30 33 11 22 [[18, 292]] 1.0 4c8b TKL_RIPK2_HUMAN TKL 3.4e-73 252.4 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 4C8BB O43353 9 316 540.0 0LI:1000 Type2 Inactive DFGout 12.8402 8.8595 None -140.63, -176.63 -153.18, 138.54 -119.75, 999.0 285.35, 113.34 999.0, 999.0 in-in in 8.2645 Saltbr-in 2.8058 HRD-in -79.98, -59.74 66.42, 17.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -39.27 APE8-dihe-out -68.6, -38.75 APE8-rot-out 169.06 APE67-dihe-in -64.78, -24.38 -61.46, -15.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4449 None None None XRAY 2.75 0.203 0.244 B 334.0 281.0 27 33 11 22 [[18, 292]] 1.0 4c8b TKL_RIPK2_HUMAN TKL 3.4e-73 252.4 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 5AR7A O43353 6 310 540.0 SR8:1311 Type2 Inactive DFGout 14.0262 8.973 None -113.55, 174.5 -138.76, 94.08 -69.87, 134.61 275.21, 95.18 -123.3, 75.72 in-in in 7.7647 Saltbr-in 2.8126 HRD-in -59.22, -52.79 59.1, 6.82 in-out-out SNCioo out-out ActLoopNT-out 14.005 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 137.51 APE8-rot-out 192.27 APE67-dihe-in -58.31, -33.64 -121.66, -0.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.71 0.184 0.225 A 326.0 278.0 27 33 17 16 [[18, 292]] 1.0 5ar7 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2

TKL_RIPK2 (Receptor-interacting serine/threonine-protein kinase 2)

Total number of chains: 72
Active chains: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 47 65.3% AF-O43353-K3A
DFGin BLBplus 10 13.9% 5NG3A
DFGin None 6 8.3% 6FU5B
DFGin BLBminus 3 4.2% 6S1FA
DFGout BBAminus 3 4.2% 6ES0A
DFGout None 3 4.2% 5AR7A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RIPK2 RIPK2_HUMAN AF-O43353-K3A O43353 10 300 540.0 No_ligand No_ligand Active DFGin 5.8355 13.9164 BLAminus -131.05, 176.49 59.07, 72.73 -86.61, 15.53 288.91, 79.18 -58.82, -34.9 in-in in 8.0725 Saltbr-in 2.7454 HRD-in -79.76, -41.87 62.78, -13.47 in-in-in SNCiii in-in ActLoopNT-in 2.8929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -60.31, 147.35 APE9-dihe-na 163.97, 163.66 APE8-dihe-in -80.92, 119.55 APE8-rot-in 303.11 APE67-dihe-in -58.79, -31.16 -43.37, -46.06 APE12-dist-in 12.1519 APE11-dist-in 8.6903 APE10-dist-in 6.3862 APE9-dist-in 3.8157 None None None AF2 -1.0 1.0 1.0 A 291.0 291.0 0 33 33 0 [[18, 292]] 1.0 AF-O43353-K3 Homo sapiens TKL_RIPK2_HUMAN TKL 3.5e-73 252.3 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5NG0A O43353 6 300 540.0 ACP:1000 ATPlike Inactive DFGin 5.8784 14.1777 BLAminus -123.27, -179.27 62.78, 77.58 -93.4, 20.77 286.94, 75.81 -61.85, -28.6 in-in in 8.2049 Saltbr-in 2.7453 HRD-in -73.28, -52.62 66.02, 10.49 in-in-out SNCiio in-out ActLoopNT-in 2.8467 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.46 APE8-dihe-in -72.18, 143.02 APE8-rot-out 185.7 APE67-dihe-in -65.61, -24.81 -104.28, 1.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8005 L294F None None XRAY 2.0 0.171 0.191 A 304.0 274.0 21 33 18 15 [[18, 292]] 1.0 5ng0 Homo sapiens TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5NG0B O43353 5 299 540.0 ACP:401 ATPlike Inactive DFGin 5.8866 14.1774 BLAminus -123.03, -178.96 62.29, 77.78 -94.31, 21.44 286.41, 77.58 -63.12, -27.82 in-in in 8.1596 Saltbr-in 2.756 HRD-in -74.08, -51.77 69.59, 3.54 in-in-out SNCiio in-out ActLoopNT-in 2.8525 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -72.33, -175.56 APE9-dihe-na 154.16, -172.85 APE8-dihe-in -105.14, 130.27 APE8-rot-in 300.55 APE67-dihe-in -61.64, -28.91 -51.09, -46.77 APE12-dist-in 11.85 APE11-dist-out 7.4022 APE10-dist-in 6.0202 APE9-dist-in 3.3421 L294F None None XRAY 2.0 0.171 0.191 B 304.0 282.0 13 33 23 10 [[18, 292]] 1.0 5ng0 Homo sapiens TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5AR3A O43353 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.9241 14.2881 BLAminus -133.03, 175.56 72.21, 76.24 -97.68, 34.32 293.9, 86.68 -66.76, -37.47 in-in in 7.9943 Saltbr-in 2.7998 HRD-in -61.0, -40.82 51.84, 8.75 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -117.65 APE9-dihe-na 164.28, -57.84 APE8-dihe-in -114.77, 107.38 APE8-rot-out 185.6 APE67-dihe-in -64.24, -32.65 -95.4, 6.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.7091 APE9-dist-out 10.828 None None None XRAY 3.23 0.192 0.254 A 326.0 279.0 26 33 19 14 [[18, 292]] 1.0 5ar3 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5AR3B O43353 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.8705 14.4182 BLAminus -128.31, 176.09 65.92, 78.1 -98.91, 35.33 294.64, 70.55 -68.55, -48.71 in-in in 8.021 Saltbr-in 2.8795 HRD-in -65.19, -46.65 55.58, 8.54 in-in-out SNCiio in-out ActLoopNT-in 2.8614 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.98 APE8-rot-out 49.06 APE67-dihe-in -39.82, -41.25 -97.08, -7.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.23 0.192 0.254 B 326.0 276.0 29 33 17 16 [[18, 292]] 1.0 5ar3 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN AF-O43353-K1A O43353 10 300 540.0 No_ligand No_ligand Inactive DFGin 5.8465 14.0078 BLAminus -127.94, 175.85 61.05, 79.69 -94.57, 16.88 285.86, 79.13 -59.24, -35.38 in-in in 8.056 Saltbr-in 2.7289 HRD-in -78.75, -47.93 64.43, -6.6 in-in-out SNCiio in-out ActLoopNT-in 2.8926 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -61.43, 170.33 APE9-dihe-na 162.37, 176.49 APE8-dihe-in -85.18, 118.94 APE8-rot-in 304.26 APE67-dihe-in -60.83, -35.85 -43.4, -45.78 APE12-dist-in 11.8663 APE11-dist-out 7.5907 APE10-dist-in 6.5108 APE9-dist-in 3.4941 None None None AF2 -1.0 1.0 1.0 A 291.0 291.0 0 33 33 0 [[18, 292]] 1.0 AF-O43353-K1 Homo sapiens TKL_RIPK2_HUMAN TKL 3.5e-73 252.3 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 8AZAA O43353 8 314 540.0 No_ligand No_ligand Inactive DFGin 6.638 14.9717 BLAminus -149.95, -164.59 59.67, 64.47 -87.13, 14.1 289.04, 7.53 -62.24, -46.57 in-out in 9.7382 Saltbr-out 8.8925 HRD-in -64.59, -39.64 71.24, -10.99 out-in-out SNCoio in-out ActLoopNT-in 3.2457 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.84 APE8-rot-out 77.29 APE67-dihe-in -86.62, -6.01 -67.77, -11.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.15 999.0 999.0 A 317.0 284.0 23 33 20 13 [[18, 292]] 1.0 8aza Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 8AZAB O43353 8 314 540.0 No_ligand No_ligand Inactive DFGin 5.3355 13.5513 BLAminus -130.42, -164.95 50.89, 68.36 -81.01, 15.64 291.47, 76.47 -59.33, -43.28 in-out in 7.362 Saltbr-out 5.6055 HRD-in -91.72, -62.3 59.19, 5.81 out-in-none SNCoin in-none ActLoopNT-in 3.4609 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.15 999.0 999.0 B 317.0 246.0 61 33 8 25 [[18, 292]] 1.0 8aza Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5AR2A O43353 4 310 540.0 No_ligand No_ligand Inactive DFGin 5.9315 14.5204 BLAminus -127.38, -176.39 62.31, 78.66 -95.92, 24.69 288.34, 80.55 -59.09, -44.11 in-in in 8.4919 Saltbr-in 2.871 HRD-in -75.18, -53.25 68.8, 7.8 in-in-out SNCiio in-out ActLoopNT-in 2.7969 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 116.83 APE9-dihe-na -174.85, -153.32 APE8-dihe-in -65.24, 140.18 APE8-rot-out 190.57 APE67-dihe-in -65.15, -22.55 -115.33, 6.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.3853 APE9-dist-out 10.606 None None None XRAY 2.44 0.172 0.211 A 326.0 277.0 30 33 19 14 [[18, 292]] 1.0 5ar2 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5AR2B O43353 4 310 540.0 No_ligand No_ligand Inactive DFGin 6.0514 14.5222 BLAminus -121.7, 177.66 61.53, 80.64 -98.26, 20.96 286.82, 74.03 -54.66, -35.04 in-in in 8.4347 Saltbr-in 3.4795 HRD-in -73.03, -54.01 65.44, 6.7 in-in-out SNCiio in-out ActLoopNT-in 2.8619 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -62.83, 130.3 APE9-dihe-na -160.33, 164.95 APE8-dihe-in -67.1, 149.78 APE8-rot-out 186.39 APE67-dihe-in -54.03, -24.23 -110.46, -3.23 APE12-dist-in 11.9721 APE11-dist-in 9.9909 APE10-dist-out 13.0438 APE9-dist-out 10.6303 None None None XRAY 2.44 0.172 0.211 B 326.0 285.0 22 33 22 11 [[18, 292]] 1.0 5ar2 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OA O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1363 13.9064 BLAminus -125.19, -174.64 59.09, 81.1 -106.86, 24.62 291.19, 85.74 -72.37, -32.43 in-none in 7.781 Saltbr-none 999.0 HRD-in -58.73, -48.93 54.24, 22.59 none-in-out SNCnio in-out ActLoopNT-in 2.7789 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 52.01 APE8-dihe-in -88.74, 126.44 APE8-rot-out 182.28 APE67-dihe-in -69.67, -13.84 -102.91, 3.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7802 None None None XRAY 2.89 0.219 0.252 A 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OB O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.075 13.8552 BLAminus -124.69, -174.05 60.01, 82.18 -107.5, 25.35 291.09, 85.35 -69.3, -34.49 in-none in 7.852 Saltbr-none 999.0 HRD-in -59.53, -49.22 54.97, 22.29 none-in-out SNCnio in-out ActLoopNT-in 2.7955 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.07 APE8-dihe-in -82.18, 127.67 APE8-rot-out 181.47 APE67-dihe-in -70.21, -14.17 -102.49, 4.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7893 None None None XRAY 2.89 0.219 0.252 B 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OC O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 5.9407 13.8497 BLAminus -124.15, -173.26 59.49, 81.39 -107.32, 24.78 291.29, 84.01 -68.0, -35.39 in-none in 7.8877 Saltbr-none 999.0 HRD-in -61.12, -47.92 53.98, 21.23 none-in-out SNCnio in-out ActLoopNT-in 2.7891 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 58.39 APE8-dihe-in -87.67, 127.44 APE8-rot-out 182.78 APE67-dihe-in -69.34, -14.96 -102.25, 3.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4354 None None None XRAY 2.89 0.219 0.252 C 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OD O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1004 13.7601 BLAminus -124.11, -174.9 59.11, 83.61 -107.83, 24.21 291.26, 84.74 -71.93, -33.31 in-none in 7.7124 Saltbr-none 999.0 HRD-in -58.77, -50.37 55.05, 21.57 none-in-out SNCnio in-out ActLoopNT-in 2.7974 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 52.34 APE8-dihe-in -81.49, 128.95 APE8-rot-out 42.92 APE67-dihe-in -70.09, -15.04 -103.55, 3.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6555 None None None XRAY 2.89 0.219 0.252 D 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OE O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1549 13.9143 BLAminus -125.32, -175.39 59.04, 81.44 -106.24, 24.21 291.63, 86.05 -73.47, -30.79 in-in in 7.8417 Saltbr-in 2.7712 HRD-in -59.5, -48.44 53.52, 22.49 in-in-out SNCiio in-out ActLoopNT-in 2.7698 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 63.28 APE8-dihe-in -87.25, 127.57 APE8-rot-out 182.11 APE67-dihe-in -69.71, -14.84 -102.46, 3.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9221 None None None XRAY 2.89 0.219 0.252 E 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OF O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1021 13.7845 BLAminus -125.28, -174.81 60.87, 81.57 -107.6, 24.8 291.53, 85.38 -69.89, -33.64 in-none in 7.7824 Saltbr-none 999.0 HRD-in -59.66, -48.54 55.22, 21.96 none-in-out SNCnio in-out ActLoopNT-in 2.7916 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 60.19 APE8-dihe-in -79.96, 131.01 APE8-rot-out 181.63 APE67-dihe-in -71.08, -14.3 -102.18, 4.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6497 None None None XRAY 2.89 0.219 0.252 F 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OG O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.0863 13.8448 BLAminus -124.86, -174.91 60.12, 81.59 -107.81, 23.84 291.29, 84.93 -68.89, -36.67 in-none in 7.7335 Saltbr-none 999.0 HRD-in -64.82, -49.86 54.77, 20.73 none-in-out SNCnio in-out ActLoopNT-in 2.7872 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 60.09 APE8-dihe-in -78.03, 125.79 APE8-rot-out 184.52 APE67-dihe-in -69.81, -14.62 -102.95, 4.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7849 None None None XRAY 2.89 0.219 0.252 G 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OH O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.0893 13.938 BLAminus -123.39, -173.38 58.61, 81.33 -105.97, 24.15 291.79, 83.79 -68.5, -35.98 in-in in 7.8994 Saltbr-in 2.7036 HRD-in -60.4, -48.42 54.87, 21.93 in-in-out SNCiio in-out ActLoopNT-in 2.7873 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -55.03 APE8-dihe-in -80.95, 128.93 APE8-rot-out 42.89 APE67-dihe-in -69.91, -14.59 -102.1, 3.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4271 None None None XRAY 2.89 0.219 0.252 H 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OI O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 5.9459 13.8868 BLAminus -123.53, -172.96 57.44, 81.36 -106.55, 24.49 290.99, 84.39 -68.01, -35.42 in-none in 7.8441 Saltbr-none 999.0 HRD-in -60.65, -52.84 62.49, 6.67 none-in-out SNCnio in-out ActLoopNT-in 2.7926 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -155.66 APE8-dihe-in -115.79, 147.83 APE8-rot-out 226.21 APE67-dihe-in -65.02, -15.65 -101.34, 1.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.4171 None None None XRAY 2.89 0.219 0.252 I 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OJ O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1261 13.8532 BLAminus -125.49, -173.66 60.26, 80.69 -107.0, 24.2 291.57, 84.27 -70.16, -35.59 in-in in 7.7874 Saltbr-in 2.7609 HRD-in -59.56, -49.0 54.34, 21.8 in-in-out SNCiio in-out ActLoopNT-in 2.8093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 62.31 APE8-dihe-in -78.64, 127.4 APE8-rot-out 183.39 APE67-dihe-in -70.3, -14.88 -101.54, 2.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.595 None None None XRAY 2.89 0.219 0.252 J 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OK O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1293 13.8059 BLAminus -123.47, -174.04 59.2, 82.79 -107.55, 23.57 291.68, 84.11 -72.29, -31.81 in-in in 7.7765 Saltbr-in 2.8227 HRD-in -59.03, -50.17 55.62, 20.99 in-in-out SNCiio in-out ActLoopNT-in 2.7932 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 54.61 APE8-dihe-in -86.36, 126.77 APE8-rot-out 185.25 APE67-dihe-in -70.21, -14.67 -104.03, 4.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9333 None None None XRAY 2.89 0.219 0.252 K 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OL O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 5.9768 13.8724 BLAminus -123.97, -173.69 59.22, 81.96 -107.43, 24.71 291.89, 82.85 -67.15, -36.07 in-in in 7.9099 Saltbr-in 2.7447 HRD-in -60.31, -48.17 54.61, 21.38 in-in-out SNCiio in-out ActLoopNT-in 2.7921 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 61.72 APE8-dihe-in -85.16, 131.31 APE8-rot-out 40.96 APE67-dihe-in -60.1, -15.62 -98.81, -9.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3911 None None None XRAY 2.89 0.219 0.252 L 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OM O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1064 13.8754 BLAminus -124.12, -175.41 59.62, 81.55 -107.4, 24.65 291.81, 83.79 -71.72, -32.48 in-none in 7.7974 Saltbr-none 999.0 HRD-in -58.16, -49.42 54.05, 21.71 none-in-out SNCnio in-out ActLoopNT-in 2.7926 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 41.26 APE8-dihe-in -78.53, 134.02 APE8-rot-out 36.01 APE67-dihe-in -69.76, -14.56 -101.27, 4.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.0598 None None None XRAY 2.89 0.219 0.252 M 310.0 276.0 30 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5ON O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.0791 13.9277 BLAminus -124.88, -172.7 59.14, 81.77 -106.98, 23.8 291.97, 82.42 -69.42, -34.18 in-none in 7.9469 Saltbr-none 999.0 HRD-in -59.84, -48.61 54.69, 21.04 none-in-out SNCnio in-out ActLoopNT-in 2.7885 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 57.95 APE8-dihe-in -84.02, 128.93 APE8-rot-out 182.08 APE67-dihe-in -69.96, -13.84 -103.42, 3.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6515 None None None XRAY 2.89 0.219 0.252 N 310.0 272.0 34 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OO O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.1838 13.8237 BLAminus -123.94, -174.15 58.85, 81.43 -106.41, 23.33 291.99, 84.7 -71.56, -32.06 in-in in 7.7913 Saltbr-in 2.7914 HRD-in -58.13, -49.83 54.51, 21.43 in-in-out SNCiio in-out ActLoopNT-in 2.7873 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 64.54 APE8-dihe-in -77.78, 132.07 APE8-rot-out 38.52 APE67-dihe-in -70.42, -14.07 -103.31, 4.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3895 None None None XRAY 2.89 0.219 0.252 O 310.0 276.0 30 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5OP O43353 5 310 540.0 9XA:401 Type1 Inactive DFGin 6.0245 13.8318 BLAminus -124.74, -174.78 59.93, 81.7 -106.98, 23.2 291.86, 82.87 -68.58, -34.35 in-none in 7.9853 Saltbr-none 999.0 HRD-in -60.06, -48.48 54.27, 16.98 none-in-out SNCnio in-out ActLoopNT-in 2.7918 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 52.76 APE8-dihe-in -83.36, 127.8 APE8-rot-out 182.51 APE67-dihe-in -70.3, -14.79 -101.64, 2.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7436 None None None XRAY 2.89 0.219 0.252 P 310.0 275.0 31 33 18 15 [[18, 292]] 1.0 5w5o Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6HMXA O43353 5 310 540.0 GEZ:401 Type1 Inactive DFGin 6.2358 14.3161 BLAminus -124.52, -177.56 66.8, 84.95 -109.14, 29.79 295.83, 94.07 -68.94, -45.49 in-in in 7.794 Saltbr-in 3.2337 HRD-in -58.38, -60.47 64.01, 17.43 in-in-out SNCiio in-out ActLoopNT-in 2.7998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -151.32 APE9-dihe-na -124.57, -125.51 APE8-dihe-in -82.66, 129.77 APE8-rot-out 187.19 APE67-dihe-in -64.93, -22.0 -95.67, -1.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.5562 APE9-dist-out 10.4465 None None None XRAY 2.53 0.166 0.192 A 311.0 280.0 26 33 18 15 [[18, 292]] 1.0 6hmx Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6HMXB O43353 5 310 540.0 GEZ:401 Type1 Inactive DFGin 6.1862 14.368 BLAminus -124.43, -176.46 65.93, 86.3 -112.37, 30.95 293.81, 90.5 -69.1, -47.31 in-in in 7.9189 Saltbr-in 3.1559 HRD-in -59.3, -60.67 66.8, 11.61 in-in-out SNCiio in-out ActLoopNT-in 2.8129 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 165.56 APE9-dihe-na -122.56, -147.83 APE8-dihe-in -59.45, 144.61 APE8-rot-out 192.64 APE67-dihe-in -62.6, -17.14 -111.83, -1.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.6547 APE9-dist-out 11.1676 None None None XRAY 2.53 0.166 0.192 B 311.0 282.0 24 33 19 14 [[18, 292]] 1.0 6hmx Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6SZEB O43353 5 310 540.0 M2B:402 Type1 Inactive DFGin 6.0394 14.5744 BLAminus -129.09, 175.84 70.06, 89.61 -113.49, 18.44 288.29, 86.33 -60.8, -47.17 in-in in 7.885 Saltbr-in 3.1277 HRD-in -75.74, -46.99 56.85, -2.91 in-in-out SNCiio in-out ActLoopNT-in 2.9116 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -136.96, -159.87 APE9-dihe-na -128.34, -119.13 APE8-dihe-in -65.42, 150.34 APE8-rot-out 193.04 APE67-dihe-in -52.67, -15.51 -114.53, -21.66 APE12-dist-none 999.0 APE11-dist-in 12.8399 APE10-dist-out 10.1206 APE9-dist-out 11.0415 None None None XRAY 2.94 0.179 0.234 B 311.0 276.0 30 33 18 15 [[18, 292]] 1.0 6sze Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6SZJB O43353 5 310 540.0 M5W:402 Type1 Inactive DFGin 6.0601 14.8025 BLAminus -127.62, -178.38 64.51, 85.71 -108.62, 30.49 299.07, 85.51 -62.99, -29.31 in-in in 8.0355 Saltbr-in 2.624 HRD-in -73.84, -57.47 64.38, 3.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -111.13, -160.71 APE9-dihe-na -124.86, -125.22 APE8-dihe-in -69.02, 143.41 APE8-rot-out 187.62 APE67-dihe-in -53.68, -19.89 -104.22, -17.47 APE12-dist-none 999.0 APE11-dist-in 13.7473 APE10-dist-out 10.3847 APE9-dist-out 10.9785 None None None XRAY 2.53 0.191 0.241 B 311.0 283.0 23 33 16 17 [[18, 292]] 1.0 6szj Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6FU5A O43353 5 315 540.0 E7N:400 Type1 Inactive DFGin 5.9695 14.1294 BLAminus -149.81, 168.35 73.17, 56.82 -87.36, -24.33 315.9, 145.59 -100.37, 169.03 in-in in 8.1619 Saltbr-in 2.9851 HRD-in -66.01, -55.94 58.15, 19.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -113.83 APE8-dihe-out -84.15, 2.15 APE8-rot-out 169.53 APE67-dihe-in -57.24, -36.43 -90.25, -17.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2691 None None None XRAY 3.26 0.231 0.271 A 317.0 282.0 29 33 13 20 [[18, 292]] 1.0 6fu5 Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6S1FB O43353 5 315 540.0 KRE:400 Type1 Inactive DFGin 6.0889 14.5519 BLAminus -136.13, -177.6 64.6, 77.45 -102.32, 33.61 287.44, 99.54 -74.42, -24.82 in-out in 8.5067 Saltbr-out 4.3325 HRD-in -68.09, -52.63 66.62, 10.13 out-in-out SNCoio in-out ActLoopNT-in 2.922 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -76.64 APE8-rot-out 48.4 APE67-dihe-in -60.75, -18.88 -96.32, -3.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.11 0.256 0.3 B 317.0 286.0 25 33 19 14 [[18, 292]] 1.0 6s1f Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6S1FD O43353 5 316 540.0 KRE:400 Type1 Inactive DFGin 5.7543 14.4945 BLAminus -135.97, -176.52 66.84, 77.7 -101.6, 58.1 285.65, 99.66 -72.67, -42.59 in-in in 8.2322 Saltbr-in 3.111 HRD-in -68.66, -53.79 68.01, 9.06 in-in-out SNCiio in-out ActLoopNT-in 3.5614 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -44.09 APE8-dihe-out -55.97, -26.25 APE8-rot-out 47.91 APE67-dihe-in -63.85, -22.41 -93.96, -4.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6285 None None None XRAY 3.11 0.256 0.3 D 317.0 288.0 24 33 16 17 [[18, 292]] 1.0 6s1f Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5AR5A O43353 4 310 540.0 IQ7:1312 Type1 Inactive DFGin 6.0809 13.9195 BLAminus -126.86, 179.69 62.84, 81.27 -103.15, 21.11 292.75, 77.76 -56.66, -44.59 in-in in 8.1036 Saltbr-in 2.8225 HRD-in -78.11, -46.09 56.4, 9.14 in-in-out SNCiio in-out ActLoopNT-in 2.806 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -92.65, 115.03 APE9-dihe-na -137.7, -171.82 APE8-dihe-in -72.24, 155.44 APE8-rot-out 54.69 APE67-dihe-in -55.38, -21.99 -110.33, -4.36 APE12-dist-none 999.0 APE11-dist-in 8.3611 APE10-dist-out 12.0932 APE9-dist-out 10.5038 None None None XRAY 2.66 0.172 0.217 A 326.0 284.0 23 33 20 13 [[18, 292]] 1.0 5ar5 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5AR5B O43353 4 310 540.0 IQ7:1311 Type1 Inactive DFGin 6.0569 14.2413 BLAminus -142.51, -179.66 67.74, 82.82 -106.87, 40.76 298.14, 96.55 -73.01, -50.49 in-in in 8.0366 Saltbr-in 2.7608 HRD-in -72.89, -56.07 62.45, 7.8 in-in-out SNCiio in-out ActLoopNT-in 2.8285 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 150.41 APE8-rot-out 179.27 APE67-dihe-in -68.25, -17.91 -122.83, 8.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.66 0.172 0.217 B 326.0 279.0 28 33 16 17 [[18, 292]] 1.0 5ar5 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5J79A O43353 2 310 540.0 6GE:401 Type1 Inactive DFGin 6.1907 14.8884 BLAminus -120.64, -169.71 53.95, 72.95 -94.42, 19.46 286.13, 70.88 -56.87, -46.79 in-in in 8.0121 Saltbr-in 2.8261 HRD-in -78.08, -43.76 61.31, -5.39 in-in-out SNCiio in-out ActLoopNT-in 2.8429 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -79.71, 177.31 APE9-dihe-na 153.91, -173.6 APE8-dihe-in -106.59, 127.13 APE8-rot-in 297.35 APE67-dihe-in -52.69, -23.77 -40.38, -60.16 APE12-dist-in 12.2053 APE11-dist-out 7.74 APE10-dist-in 6.1582 APE9-dist-in 3.5204 None None None XRAY 2.69 0.164 0.219 A 326.0 283.0 26 33 23 10 [[18, 292]] 1.0 5j79 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5J79B O43353 5 310 540.0 6GE:401 Type1 Inactive DFGin 6.2146 14.6915 BLAminus -127.38, -171.48 58.91, 71.21 -93.63, 17.06 288.17, 81.6 -55.96, -36.73 in-in in 7.8932 Saltbr-in 2.8213 HRD-in -66.88, -48.06 57.22, 15.22 in-in-out SNCiio in-out ActLoopNT-in 2.8949 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -149.85 APE8-dihe-in -92.95, 137.0 APE8-rot-out 192.1 APE67-dihe-in -64.77, -22.33 -110.03, 6.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1187 None None None XRAY 2.69 0.164 0.219 B 326.0 277.0 29 33 18 15 [[18, 292]] 1.0 5j79 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5NG2A O43353 5 298 540.0 STU:401 Type1 Inactive DFGin 5.9592 13.8755 BLAminus -127.83, 178.19 61.49, 80.49 -96.67, 24.09 288.33, 78.8 -62.82, -31.8 in-in in 8.0911 Saltbr-in 2.9024 HRD-in -73.87, -50.37 57.71, 19.44 in-in-out SNCiio in-out ActLoopNT-in 2.8273 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 149.89 APE8-dihe-in -77.86, 146.25 APE8-rot-out 189.94 APE67-dihe-in -66.59, -20.81 -105.1, 1.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8555 D146N None None XRAY 2.8 0.209 0.226 A 304.0 274.0 20 33 19 14 [[18, 292]] 1.0 5ng2 Homo sapiens TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5NG2B O43353 5 298 540.0 STU:401 Type1 Inactive DFGin 5.987 13.9001 BLAminus -127.96, 178.42 61.45, 80.21 -96.5, 23.45 288.92, 78.23 -62.02, -31.71 in-in in 8.0927 Saltbr-in 2.8937 HRD-in -73.84, -50.5 58.4, 18.77 in-in-out SNCiio in-out ActLoopNT-in 2.8272 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.58 APE8-dihe-in -77.44, 145.88 APE8-rot-out 189.53 APE67-dihe-in -67.7, -20.58 -104.84, 1.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7903 D146N None None XRAY 2.8 0.209 0.226 B 304.0 278.0 16 33 18 15 [[18, 292]] 1.0 5ng2 Homo sapiens TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6UL8A O43353 5 310 540.0 Q9J:401 Type1.5_Back Inactive DFGin 6.0845 13.9036 BLAminus -138.68, 177.39 65.76, 84.99 -107.51, 38.57 290.05, 69.88 -77.69, -36.11 in-in in 7.9595 Saltbr-in 3.1856 HRD-in -69.43, -53.26 62.34, 12.17 in-in-out SNCiio in-out ActLoopNT-in 2.9522 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -165.87 APE8-dihe-in -60.17, 149.46 APE8-rot-out 196.86 APE67-dihe-in -58.24, -30.16 -112.68, 2.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5384 C7S,S168C None None XRAY 2.68 0.185 0.22 A 306.0 279.0 27 33 16 17 [[18, 292]] 1.0 6ul8 Homo sapiens TKL_RIPK2_HUMAN TKL 1.9e-72 250.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6UL8B O43353 5 310 540.0 Q9J:402 Type1.5_Back Inactive DFGin 6.1752 13.9804 BLAminus -122.99, -178.46 65.81, 77.15 -98.02, 36.9 291.09, 78.99 -72.1, -29.98 in-in in 8.057 Saltbr-in 3.0831 HRD-in -78.67, -48.07 63.33, 13.97 in-in-out SNCiio in-out ActLoopNT-in 2.7016 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -175.3 APE8-dihe-in -93.82, 150.28 APE8-rot-out 194.98 APE67-dihe-in -68.22, -20.36 -108.06, 1.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4783 C7S,S168C None None XRAY 2.68 0.185 0.22 B 306.0 283.0 23 33 16 17 [[18, 292]] 1.0 6ul8 Homo sapiens TKL_RIPK2_HUMAN TKL 1.9e-72 250.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6RN8A O43353 5 310 540.0 K9T:401 Type1.5_Back Inactive DFGin 6.0981 13.8907 BLAminus -121.2, -174.58 53.58, 84.93 -101.75, 30.28 282.16, 80.1 -71.87, -31.63 in-in in 7.9813 Saltbr-in 2.8706 HRD-in -66.39, -50.33 64.83, 11.58 in-in-out SNCiio in-out ActLoopNT-in 2.8624 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.27 APE8-dihe-in -62.06, 149.59 APE8-rot-out 197.55 APE67-dihe-in -63.99, -18.48 -118.03, -0.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6245 None None None XRAY 2.69 0.178 0.212 A 311.0 281.0 25 33 18 15 [[18, 292]] 1.0 6rn8 Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6RN8B O43353 5 310 540.0 K9T:402 Type1.5_Back Inactive DFGin 6.0131 13.7399 BLAminus -122.39, -174.33 51.92, 85.84 -100.82, 20.49 283.98, 79.06 -64.39, -29.28 in-in in 8.2166 Saltbr-in 2.9524 HRD-in -60.94, -56.67 69.44, 9.97 in-in-out SNCiio in-out ActLoopNT-in 2.8249 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -139.63, -164.48 APE9-dihe-na -115.85, -133.91 APE8-dihe-in -56.11, 149.92 APE8-rot-out 199.64 APE67-dihe-in -63.61, -17.82 -118.75, -0.13 APE12-dist-none 999.0 APE11-dist-in 13.3049 APE10-dist-out 10.53 APE9-dist-out 10.9757 None None None XRAY 2.69 0.178 0.212 B 311.0 284.0 22 33 20 13 [[18, 292]] 1.0 6rn8 Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6RNAA O43353 5 310 540.0 KA2:401 Type1.5_Back Inactive DFGin 6.0963 14.1187 BLAminus -118.69, -178.94 59.47, 86.33 -104.16, 26.83 288.87, 81.14 -69.66, -36.26 in-in in 8.0213 Saltbr-in 2.8713 HRD-in -59.8, -53.12 61.06, 18.18 in-in-out SNCiio in-out ActLoopNT-in 2.806 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -150.26 APE9-dihe-na -111.81, -125.99 APE8-dihe-in -71.22, 149.14 APE8-rot-out 191.73 APE67-dihe-in -63.27, -18.82 -116.66, -2.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.3587 APE9-dist-out 10.6079 None None None XRAY 2.62 0.162 0.19 A 311.0 277.0 29 33 19 14 [[18, 292]] 1.0 6rna Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6RNAB O43353 4 310 540.0 KA2:401 Type1.5_Back Inactive DFGin 6.0802 14.2468 BLAminus -120.18, -176.72 60.07, 86.2 -105.54, 23.51 290.08, 82.68 -62.84, -38.47 in-in in 8.0698 Saltbr-in 3.2503 HRD-in -61.33, -52.71 61.11, 15.17 in-in-out SNCiio in-out ActLoopNT-in 2.8167 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -137.02, 170.76 APE9-dihe-na -116.32, -128.61 APE8-dihe-in -67.14, 150.22 APE8-rot-out 193.81 APE67-dihe-in -62.73, -17.87 -118.35, -1.43 APE12-dist-none 999.0 APE11-dist-in 11.9097 APE10-dist-out 10.6231 APE9-dist-out 11.1029 None None None XRAY 2.62 0.162 0.19 B 311.0 284.0 23 33 20 13 [[18, 292]] 1.0 6rna Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 8X2OA O43353 8 316 540.0 6IL:401 Type1.5_Back Inactive DFGin 6.1082 14.063 BLAminus -124.76, -178.24 59.51, 83.58 -103.26, 21.59 286.78, 67.68 -61.63, -25.69 in-in in 8.1719 Saltbr-in 2.8992 HRD-in -73.25, -53.73 66.65, 12.78 in-in-out SNCiio in-out ActLoopNT-in 2.8222 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -34.29 APE8-dihe-out -78.32, -9.99 APE8-rot-none 999.0 APE67-dihe-in -62.03, -22.4 -97.2, -12.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7076 None None None XRAY 2.26 0.215 0.254 A 316.0 278.0 31 33 17 16 [[18, 292]] 1.0 8x2o Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 8X2OB O43353 9 316 540.0 6IL:401 Type1.5_Back Inactive DFGin 5.9557 14.0215 BLAminus -124.91, 179.9 57.85, 85.82 -101.47, 22.95 284.79, 67.03 -59.39, -22.8 in-in in 8.2288 Saltbr-in 2.7018 HRD-in -76.1, -54.35 62.81, 14.76 in-in-out SNCiio in-out ActLoopNT-in 2.6809 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.95 APE8-dihe-out -77.16, -10.52 APE8-rot-out 66.48 APE67-dihe-in -64.46, -19.1 -99.04, -14.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1454 None None None XRAY 2.26 0.215 0.254 B 316.0 287.0 21 33 17 16 [[18, 292]] 1.0 8x2o Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6S1FA O43353 5 316 540.0 KRE:400 Type1 Inactive DFGin 5.8865 14.1537 BLBminus -136.68, -174.64 68.69, 76.96 -104.64, -172.79 287.96, 1.48 75.58, -141.77 in-in in 7.9208 Saltbr-in 2.8937 HRD-in -68.42, -54.93 68.33, 10.57 in-out-out SNCioo out-out ActLoopNT-out 14.855 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -44.24 APE8-dihe-out -97.88, 11.31 APE8-rot-out 48.21 APE67-dihe-in -64.33, -18.5 -93.61, -4.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.7127 None None None XRAY 3.11 0.256 0.3 A 317.0 291.0 21 33 17 16 [[18, 292]] 1.0 6s1f Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6S1FC O43353 5 315 540.0 KRE:400 Type1 Inactive DFGin 6.4178 14.4655 BLBminus -136.0, -178.34 66.52, 77.3 -105.6, -150.08 288.38, 1.24 54.26, -143.32 in-in in 8.103 Saltbr-in 3.2949 HRD-in -66.98, -53.6 67.88, 10.57 in-out-out SNCioo out-out ActLoopNT-out 14.6769 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -39.08 APE8-dihe-out -92.13, -29.89 APE8-rot-out 48.51 APE67-dihe-in -60.41, -17.19 -93.43, -2.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.1049 None None None XRAY 3.11 0.256 0.3 C 317.0 289.0 22 33 17 16 [[18, 292]] 1.0 6s1f Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5AR8B O43353 8 310 540.0 XYW:1311 Type1.5_Back Inactive DFGin 6.4448 14.5481 BLBminus -138.31, -177.12 57.02, 46.97 -53.35, 139.38 296.36, 78.76 -77.07, 61.56 out-out out 11.7203 Saltbr-out 9.6727 HRD-in -73.74, -57.92 63.65, 13.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 6.02 APE9-dihe-na -70.75, 168.46 APE8-dihe-in -59.78, 148.4 APE8-rot-out 194.81 APE67-dihe-in -57.35, -6.9 -103.85, -13.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.4251 APE9-dist-out 10.6323 None None None XRAY 2.79 0.204 0.233 B 326.0 274.0 29 33 14 19 [[18, 292]] 1.0 5ar8 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5NG3A O43353 8 297 540.0 No_ligand No_ligand Inactive DFGin 5.5395 12.8991 BLBplus -112.38, 160.58 70.97, 23.75 -68.8, 144.03 47.35, 86.99 65.51, 12.2 out-none out 12.7512 Saltbr-none 999.0 HRD-in -71.1, -58.95 67.21, 2.05 none-out-out SNCnoo out-out ActLoopNT-out 9.7889 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -127.51, 155.11 APE9-dihe-na -75.1, 166.99 APE8-dihe-in -61.92, 146.05 APE8-rot-out 193.53 APE67-dihe-in -56.91, -27.84 -109.89, 2.62 APE12-dist-none 999.0 APE11-dist-out 18.3793 APE10-dist-out 14.8698 APE9-dist-out 10.1617 K47R TPO111 TPO111 XRAY 2.6 0.234 0.269 A 304.0 284.0 6 33 27 6 [[18, 292]] 1.0 5ng3 Homo sapiens TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5NG3B O43353 9 297 540.0 No_ligand No_ligand Inactive DFGin 5.6695 12.9014 BLBplus -112.34, 160.48 70.49, 24.2 -68.43, 144.17 47.17, 86.84 64.87, 12.81 out-none out 12.9136 Saltbr-none 999.0 HRD-in -70.57, -58.52 66.45, 2.64 none-out-out SNCnoo out-out ActLoopNT-out 9.7093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -51.15 APE9-dihe-na -75.96, 168.48 APE8-dihe-in -61.9, 146.98 APE8-rot-out 192.74 APE67-dihe-in -54.8, -29.64 -109.73, 3.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.1216 APE9-dist-out 9.6412 K47R None None XRAY 2.6 0.234 0.269 B 304.0 275.0 14 33 25 8 [[18, 292]] 1.0 5ng3 Homo sapiens TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5NG3C O43353 9 297 540.0 No_ligand No_ligand Inactive DFGin 5.5896 12.944 BLBplus -112.71, 161.13 70.64, 23.93 -68.42, 144.19 47.15, 87.05 64.5, 12.74 out-none out 12.8447 Saltbr-none 999.0 HRD-in -71.02, -58.72 67.3, 1.13 none-out-out SNCnoo out-out ActLoopNT-out 9.8157 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 160.87 APE8-dihe-in -62.18, 147.01 APE8-rot-out 192.72 APE67-dihe-in -54.87, -29.19 -109.49, 3.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.9977 K47R None None XRAY 2.6 0.234 0.269 C 304.0 272.0 17 33 24 9 [[18, 292]] 1.0 5ng3 Homo sapiens TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5NG3D O43353 9 297 540.0 No_ligand No_ligand Inactive DFGin 5.5736 12.8886 BLBplus -112.39, 160.12 71.59, 23.49 -69.04, 143.91 48.32, 92.26 67.92, 12.12 out-none out 12.805 Saltbr-none 999.0 HRD-in -69.99, -59.28 66.07, 2.93 none-out-out SNCnoo out-out ActLoopNT-out 9.6277 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -124.38, 144.23 APE9-dihe-na -74.77, 167.56 APE8-dihe-in -63.05, 146.04 APE8-rot-out 193.19 APE67-dihe-in -62.45, -21.47 -111.58, 2.98 APE12-dist-none 999.0 APE11-dist-out 18.2155 APE10-dist-out 15.1103 APE9-dist-out 10.1475 K47R TPO111 TPO111 XRAY 2.6 0.234 0.269 D 304.0 279.0 10 33 27 6 [[18, 292]] 1.0 5ng3 Homo sapiens TKL_RIPK2_HUMAN TKL 2.2e-72 249.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6SZEA O43353 5 310 540.0 M2B:401 Type1 Inactive DFGin 4.6852 14.1881 BLBplus -140.38, 176.81 56.22, 39.89 -108.75, 153.17 54.91, 95.34 65.03, 43.78 in-in in 7.7009 Saltbr-in 2.8207 HRD-in -69.61, -60.35 64.99, -5.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 142.75 APE8-rot-out 182.72 APE67-dihe-in -63.71, -17.61 -123.61, 3.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.94 0.179 0.234 A 311.0 274.0 32 33 13 20 [[18, 292]] 1.0 6sze Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6SZJA O43353 5 310 540.0 M5W:401 Type1 Inactive DFGin 4.728 14.5425 BLBplus -128.88, 175.29 56.57, 61.59 -132.22, 139.55 60.02, 89.16 45.92, 68.66 in-in in 7.8419 Saltbr-in 3.596 HRD-in -66.36, -57.71 64.68, 3.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -118.11 APE8-dihe-in -97.65, 128.8 APE8-rot-out 180.19 APE67-dihe-in -65.16, -18.87 -95.83, 0.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.12 None None None XRAY 2.53 0.191 0.241 A 311.0 279.0 27 33 13 20 [[18, 292]] 1.0 6szj Homo sapiens TKL_RIPK2_HUMAN TKL 4.5e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5AR4A O43353 5 310 540.0 SB2:1311 Type1 Inactive DFGin 4.6318 14.0452 BLBplus -139.45, 166.57 61.79, 49.71 -115.35, 148.15 54.64, 94.62 62.79, 37.41 in-in in 7.6452 Saltbr-in 2.8208 HRD-in -68.8, -62.63 63.67, 2.11 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.58 APE8-rot-out 174.49 APE67-dihe-in -67.48, -22.2 -110.63, -5.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.18 0.216 A 326.0 274.0 32 33 12 21 [[18, 292]] 1.0 5ar4 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5AR4B O43353 6 310 540.0 SB2:1311 Type1 Inactive DFGin 4.569 14.0575 BLBplus -133.48, 172.27 57.95, 41.37 -105.11, 150.43 49.24, 89.44 68.18, 19.95 in-in in 7.5793 Saltbr-in 2.9036 HRD-in -72.79, -67.06 71.53, 1.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.45 APE8-dihe-in -96.06, 114.48 APE8-rot-out 179.92 APE67-dihe-in -54.67, -24.97 -78.06, -12.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3315 None None None XRAY 2.7 0.18 0.216 B 326.0 279.0 26 33 13 20 [[18, 292]] 1.0 5ar4 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5J7BA O43353 5 310 540.0 6GD:401 Type1 Inactive DFGin 4.5876 14.4045 BLBplus -129.48, 168.3 62.65, 43.46 -109.82, 148.85 51.68, 86.16 70.79, 38.23 in-in in 7.8674 Saltbr-in 2.8886 HRD-in -71.32, -62.27 67.57, -0.37 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -116.74 APE8-dihe-in -88.25, 140.13 APE8-rot-out 180.7 APE67-dihe-in -66.48, -20.9 -107.99, 7.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.229 None None None XRAY 2.53 0.182 0.233 A 326.0 277.0 29 33 13 20 [[18, 292]] 1.0 5j7b Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5J7BB O43353 4 310 540.0 6GD:401 Type1 Inactive DFGin 4.6349 14.6096 BLBplus -120.37, 168.05 63.64, 41.51 -106.03, 152.65 50.14, 87.53 73.72, 5.94 in-in in 7.9759 Saltbr-in 2.7682 HRD-in -76.48, -65.75 71.16, -2.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -95.83, 157.85 APE9-dihe-na -91.06, -150.2 APE8-dihe-in -80.84, 153.57 APE8-rot-out 185.33 APE67-dihe-in -54.63, -17.55 -109.62, -19.05 APE12-dist-none 999.0 APE11-dist-out 16.3249 APE10-dist-out 13.7217 APE9-dist-out 10.4684 None None None XRAY 2.53 0.182 0.233 B 326.0 281.0 26 33 15 18 [[18, 292]] 1.0 5j7b Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5JA O43353 9 310 540.0 9WS:401 Type1 Inactive DFGin 6.0636 11.774 None -119.1, 58.24 -81.72, 48.17 -169.21, 999.0 29.16, 78.79 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-out -76.29, 33.51 -93.6, 157.22 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.86 APE8-rot-out 51.78 APE67-dihe-in -59.34, -25.23 -55.53, -13.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.22 0.268 A 310.0 251.0 51 33 10 23 [[18, 292]] 1.0 5w5j Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5W5JB O43353 10 311 540.0 9WS:401 Type1 Inactive DFGin 10.6638 12.427 None -117.65, 82.68 -113.99, 168.64 -106.24, 999.0 178.58, 75.53 999.0, 999.0 out-none out 12.7338 Saltbr-none 999.0 HRD-none 999.0, -168.86 -106.07, -61.78 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.02 APE8-rot-out 182.83 APE67-dihe-in -59.02, -25.25 -78.75, -12.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.22 0.268 B 310.0 257.0 45 33 10 23 [[18, 292]] 1.0 5w5j Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6FU5B O43353 5 316 540.0 E7N:400 Type1 Inactive DFGin 5.9966 14.4823 None -152.27, 168.89 72.98, 59.18 -85.18, 999.0 313.99, 145.21 999.0, 999.0 in-in in 8.2541 Saltbr-in 3.2918 HRD-in -67.82, -57.29 58.73, 20.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 33.08 APE8-dihe-out -121.2, 5.37 APE8-rot-out 45.9 APE67-dihe-in -54.25, -32.94 -85.9, -14.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.8037 None None None XRAY 3.26 0.231 0.271 B 317.0 286.0 26 33 11 22 [[18, 292]] 1.0 6fu5 Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 9F3VA O43353 9 314 540.0 A1H90:401 Type1 Inactive DFGin 6.1196 11.6318 None -123.15, 40.28 -90.71, 70.0 -87.39, 999.0 300.2, 126.34 999.0, 999.0 out-out out 12.4585 Saltbr-out 11.3915 HRD-out -117.23, 144.8 -142.51, 123.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.92 APE8-rot-out 194.2 APE67-dihe-in -71.3, -18.73 -128.19, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.943 0.222 0.256 A 320.0 271.0 35 33 10 23 [[18, 292]] 1.0 9f3v Homo sapiens TKL_RIPK2_HUMAN TKL 5e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 9F3VB O43353 9 315 540.0 A1H90:401 Type1 Inactive DFGin 6.1588 11.1837 None -124.64, 37.34 -86.49, 73.07 -88.12, -171.81 302.83, 123.42 -66.33, -25.78 out-out out 11.9434 Saltbr-out 13.034 HRD-out -117.06, 146.57 -143.26, 122.43 out-out-out SNCooo out-out ActLoopNT-out 9.0527 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.32 APE8-rot-out 190.74 APE67-dihe-in -70.4, -21.68 -126.9, 0.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.943 0.222 0.256 B 320.0 278.0 29 33 15 18 [[18, 292]] 1.0 9f3v Homo sapiens TKL_RIPK2_HUMAN TKL 5e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5AR8A O43353 9 310 540.0 XYW:1311 Type1.5_Back Inactive DFGin 6.4925 13.7371 None -145.13, 172.75 65.95, 57.21 -55.82, 999.0 299.0, 99.97 999.0, 999.0 out-out out 11.8351 Saltbr-out 10.7188 HRD-in -72.15, -51.23 60.29, 11.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -41.34 APE8-dihe-in -100.17, 152.95 APE8-rot-out 191.99 APE67-dihe-in -63.35, -16.88 -126.62, -2.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0407 None None None XRAY 2.79 0.204 0.233 A 326.0 255.0 47 33 11 22 [[18, 292]] 1.0 5ar8 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6ES0A O43353 5 316 540.0 BW8:401 Type2 Inactive DFGout 14.1211 8.9233 BBAminus -138.52, -178.62 -150.57, 111.81 -84.27, -8.2 285.77, 101.08 -70.34, 157.2 in-in in 8.2327 Saltbr-in 2.7817 HRD-in -75.11, -58.32 62.84, 20.2 in-out-out SNCioo out-out ActLoopNT-out 10.2709 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -68.98 APE8-dihe-out -81.68, 11.21 APE8-rot-out 56.58 APE67-dihe-in -75.1, -13.25 -106.14, -1.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.3743 None None None XRAY 2.38 0.216 0.258 A 317.0 288.0 24 33 16 17 [[18, 292]] 1.0 6es0 Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 6ES0B O43353 5 315 540.0 BW8:401 Type2 Inactive DFGout 14.0432 9.0664 BBAminus -137.57, -177.15 -156.56, 109.76 -81.72, 4.5 291.34, 90.75 -64.05, 168.24 in-in in 8.6494 Saltbr-in 2.8001 HRD-in -85.89, -59.6 64.07, 17.46 in-out-out SNCioo out-out ActLoopNT-out 10.8379 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.42 APE8-dihe-in -71.95, 155.63 APE8-rot-out 184.48 APE67-dihe-in -73.42, -23.5 -115.93, 5.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.1118 None None None XRAY 2.38 0.216 0.258 B 317.0 287.0 24 33 17 16 [[18, 292]] 1.0 6es0 Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5AR7B O43353 6 310 540.0 SR8:1311 Type2 Inactive DFGout 14.1236 8.7475 BBAminus -122.07, 179.23 -147.51, 96.13 -66.21, -16.47 275.32, 92.13 58.18, 999.0 in-in in 7.8442 Saltbr-in 2.8175 HRD-in -67.02, -63.9 68.7, 14.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -175.85 APE8-dihe-in -67.25, 147.17 APE8-rot-out 32.44 APE67-dihe-in -57.24, -19.17 -103.63, -6.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.709 None None None XRAY 2.71 0.184 0.225 B 326.0 279.0 26 33 12 21 [[18, 292]] 1.0 5ar7 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 4C8BA O43353 8 316 540.0 0LI:1000 Type2 Inactive DFGout 12.7285 8.5841 None -142.99, -175.55 -154.35, 140.4 -129.56, 999.0 290.55, 114.67 999.0, 999.0 in-in in 8.2431 Saltbr-in 2.8173 HRD-in -79.84, -58.2 64.89, 19.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.9 APE8-dihe-out -84.71, -55.98 APE8-rot-none 999.0 APE67-dihe-in -64.98, -25.64 -68.13, -16.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2944 None None None XRAY 2.75 0.203 0.244 A 334.0 279.0 30 33 11 22 [[18, 292]] 1.0 4c8b Homo sapiens TKL_RIPK2_HUMAN TKL 3.4e-73 252.4 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 4C8BB O43353 9 316 540.0 0LI:1000 Type2 Inactive DFGout 12.8402 8.8595 None -140.63, -176.63 -153.18, 138.54 -119.75, 999.0 285.35, 113.34 999.0, 999.0 in-in in 8.2645 Saltbr-in 2.8058 HRD-in -79.98, -59.74 66.42, 17.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -39.27 APE8-dihe-out -68.6, -38.75 APE8-rot-out 169.06 APE67-dihe-in -64.78, -24.38 -61.46, -15.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4449 None None None XRAY 2.75 0.203 0.244 B 334.0 281.0 27 33 11 22 [[18, 292]] 1.0 4c8b Homo sapiens TKL_RIPK2_HUMAN TKL 3.4e-73 252.4 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
RIPK2 RIPK2_HUMAN 5AR7A O43353 6 310 540.0 SR8:1311 Type2 Inactive DFGout 14.0262 8.973 None -113.55, 174.5 -138.76, 94.08 -69.87, 134.61 275.21, 95.18 -123.3, 75.72 in-in in 7.7647 Saltbr-in 2.8126 HRD-in -59.22, -52.79 59.1, 6.82 in-out-out SNCioo out-out ActLoopNT-out 14.005 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 137.51 APE8-rot-out 192.27 APE67-dihe-in -58.31, -33.64 -121.66, -0.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.71 0.184 0.225 A 326.0 278.0 27 33 17 16 [[18, 292]] 1.0 5ar7 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2

TKL_RIPK2 (Receptor-interacting serine/threonine-protein kinase 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name