CAMK_PRKAA1 (5'-AMP-activated protein kinase catalytic subunit alpha-1)

Total number of chains: 14
Active chains: 2
Family: CAMK
Uniprot: AAPK1_HUMAN
Kinase Domain Residues: 27 - 279
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 35.7% AF-Q13131-K3A
DFGin None 5 35.7% 7JHGA
DFGin ABAminus 2 14.3% 6C9FA
DFGinter None 2 14.3% 4REDB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
6C9JA 22 559 559.0 R34:60601,STU:60602 Allosteric,Type1 Active DFGin 6.98 13.932 BLAminus -148.31, -179.86 61.68, 68.06 -82.96, 8.26 285.07, 89.54 -49.65, -37.12 out-in out 10.05 Saltbr-in 3.025 HRD-in -61.18, -61.45 68.18, -7.34 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.03, 155.55 APE9-dihe-na 81.79, 170.06 APE8-dihe-in -65.93, 140.22 APE8-rot-in 298.24 APE67-dihe-in -65.83, -31.14 -52.06, -38.38 APE12-dist-in 8.312 APE11-dist-in 11.199 APE10-dist-in 5.64 APE9-dist-in 4.101 None TPO183 TPO183 XRAY 3.05 0.215 0.225 A 494 384 0 0 0 0 [[27, 279]] 1.0 6c9j CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AF-Q13131-K3A 19 287 559.0 No_ligand No_ligand Active DFGin 6.501 14.903 BLAminus -129.08, -177.68 47.33, 68.2 -74.74, 17.85 288.58, 82.81 -63.19, -24.19 in-in in 9.323 Saltbr-in 2.709 HRD-in -78.49, -48.1 65.48, -2.12 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.89, 169.2 APE9-dihe-na 88.63, -177.87 APE8-dihe-in -80.88, 127.64 APE8-rot-in 293.69 APE67-dihe-in -63.96, -18.51 -42.59, -48.91 APE12-dist-in 8.22 APE11-dist-in 11.595 APE10-dist-in 6.089 APE9-dist-in 4.45 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[27, 279]] 1.0 AF-Q13131-K3 CAMK_PRKAA1_HUMAN CAMK 5.5e-90 307.1 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
6C9FA 22 558 559.0 R34:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.728 14.295 ABAminus -116.49, -61.55 -94.26, 110.71 -99.52, 6.4 287.66, 85.72 -50.13, -39.13 out-out out 10.713 Saltbr-out 5.319 HRD-in -66.33, -58.11 53.99, 16.31 out-in-out SNCoio in-out ActLoopNT-in 2.771 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.89, 155.28 APE9-dihe-na 94.11, 171.31 APE8-dihe-in -69.7, 144.51 APE8-rot-out 175.9 APE67-dihe-in -64.59, -37.19 -54.17, -35.84 APE12-dist-in 8.268 APE11-dist-in 10.73 APE10-dist-in 5.149 APE9-dist-in 4.237 None TPO183 TPO183 XRAY 2.924 0.229 0.245 A 494 371 0 0 0 0 [[27, 279]] 1.0 6c9f CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
7JIJA 22 559 559.0 No_ligand No_ligand Inactive DFGin 8.307 13.768 ABAminus -95.45, -62.92 -74.4, 116.63 -122.62, 17.87 285.24, 153.02 -61.65, -40.14 out-in out 10.147 Saltbr-in 3.554 HRD-out -97.22, 118.75 -68.27, -49.38 in-in-in SNCiii in-in ActLoopNT-in 3.099 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.85, -164.16 APE9-dihe-na 97.91, 178.24 APE8-dihe-in -54.32, 146.84 APE8-rot-in 296.81 APE67-dihe-in -71.31, -40.54 -72.68, -33.78 APE12-dist-in 9.382 APE11-dist-in 11.619 APE10-dist-in 6.959 APE9-dist-in 5.882 None TPO183 TPO183 XRAY 5.5 0.253 0.323 A 484 407 0 0 0 0 [[27, 279]] 1.0 7jij CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
6C9GA 22 558 559.0 R93:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.907 14.399 BLAminus -135.02, 170.21 60.34, 77.63 -85.45, 11.43 285.05, 75.57 -50.8, -32.37 out-out out 10.695 Saltbr-out 5.597 HRD-in -79.11, -48.44 68.49, -16.14 out-in-out SNCoio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.15, 158.83 APE9-dihe-na 72.57, 174.42 APE8-dihe-in -69.04, 143.86 APE8-rot-out 162.73 APE67-dihe-in -62.81, -32.14 -55.18, -38.62 APE12-dist-in 8.45 APE11-dist-in 11.031 APE10-dist-in 6.008 APE9-dist-in 4.009 None TPO183 TPO183 XRAY 2.7 0.205 0.24 A 494 384 0 0 0 0 [[27, 279]] 1.0 6c9g CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
6C9HA 22 558 559.0 R34:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.712 14.382 BLAminus -138.26, 171.2 60.5, 73.75 -84.01, 6.76 285.61, 85.73 -48.49, -36.53 out-out out 10.649 Saltbr-out 5.631 HRD-in -69.22, -48.97 68.92, -5.29 out-in-out SNCoio in-out ActLoopNT-in 3.017 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.6, 158.62 APE9-dihe-na 60.32, -132.0 APE8-dihe-in -130.57, 153.41 APE8-rot-out 177.79 APE67-dihe-in -63.0, -34.49 -63.07, -41.05 APE12-dist-in 8.655 APE11-dist-in 10.618 APE10-dist-in 6.189 APE9-dist-in 3.873 None None None XRAY 2.65 0.215 0.242 A 494 433 0 0 0 0 [[27, 279]] 1.0 6c9h CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AF-Q13131-K1A 19 287 559.0 No_ligand No_ligand Inactive DFGin 6.939 14.365 BLAminus -126.29, 178.95 47.22, 74.39 -80.07, 15.61 284.51, 79.75 -61.56, -31.72 in-in in 9.375 Saltbr-in 2.671 HRD-in -78.83, -47.66 63.91, -0.09 in-in-out SNCiio in-out ActLoopNT-in 2.996 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.96, 168.44 APE9-dihe-na 93.06, 171.61 APE8-dihe-in -71.73, 134.73 APE8-rot-out 179.4 APE67-dihe-in -66.08, -18.64 -47.45, -46.11 APE12-dist-in 8.246 APE11-dist-in 11.392 APE10-dist-in 5.597 APE9-dist-in 3.639 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[27, 279]] 1.0 AF-Q13131-K1 CAMK_PRKAA1_HUMAN CAMK 5.5e-90 307.1 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
7JHHA 22 559 559.0 No_ligand No_ligand Inactive DFGin 4.408 14.053 None -72.1, -47.74 -146.41, 153.99 -125.94, -39.52 58.73, 92.29 -80.39, -25.75 out-out out 12.69 Saltbr-out 12.814 HRD-out -119.19, 87.53 -68.79, -38.46 out-out-out SNCooo out-out ActLoopNT-out 5.3 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -67.5, -39.69 APE9-dihe-na -65.47, -47.47 APE8-dihe-in -135.51, 108.04 APE8-rot-in 295.83 APE67-dihe-in -65.04, -42.29 -74.22, -38.89 APE12-dist-in 11.962 APE11-dist-out 17.013 APE10-dist-out 19.009 APE9-dist-out 12.742 None None None EM 3.92 999.0 999.0 A 484 379 0 0 0 0 [[27, 279]] 1.0 7jhh CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
7JHGA 22 559 559.0 TAK:60601 Type1 Inactive DFGin 3.958 12.385 None -75.55, -57.95 -128.11, 115.65 -75.63, -58.59 53.99, 94.22 -113.12, -1.21 out-out out 12.413 Saltbr-out 12.276 HRD-out -118.93, 87.19 -68.87, -35.95 out-out-out SNCooo out-out ActLoopNT-out 5.755 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -71.04, -42.27 APE9-dihe-na -68.52, -40.55 APE8-dihe-in -128.24, 81.11 APE8-rot-out 178.77 APE67-dihe-in -67.22, -49.66 -68.38, -37.04 APE12-dist-in 12.585 APE11-dist-out 17.761 APE10-dist-out 17.985 APE9-dist-out 11.239 None None None EM 3.47 999.0 999.0 A 484 380 0 0 0 0 [[27, 279]] 1.0 7jhg CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
7M74A 22 559 559.0 TAK:60601 Type1 Inactive DFGin 4.811 13.234 None -76.76, -62.2 -122.49, 107.13 -85.46, -38.34 61.13, 92.05 -117.4, -4.69 out-out out 13.695 Saltbr-out 11.239 HRD-out -115.45, 89.03 -69.29, -34.6 out-out-out SNCooo out-out ActLoopNT-out 5.607 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -77.56, -39.26 APE9-dihe-na -72.79, -36.52 APE8-dihe-in -124.27, 83.8 APE8-rot-out 178.33 APE67-dihe-in -73.53, -46.6 -74.47, -34.26 APE12-dist-in 12.858 APE11-dist-out 17.936 APE10-dist-out 18.145 APE9-dist-out 11.108 None None None EM 3.93 999.0 999.0 A 484 380 0 0 0 0 [[27, 279]] 1.0 7m74 CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
4RERA 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.724 14.682 None -104.41, -74.44 -70.58, 123.21 -111.45, 7.12 271.34, 95.59 -64.34, -25.66 in-in in 9.394 Saltbr-in 3.168 HRD-out -106.73, 104.09 -76.93, -37.65 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.23, 162.43 APE9-dihe-na 109.76, -176.61 APE8-dihe-in -65.38, 159.16 APE8-rot-in 282.67 APE67-dihe-in -82.84, -28.7 -67.98, -40.26 APE12-dist-in 8.764 APE11-dist-in 11.102 APE10-dist-in 5.353 APE9-dist-in 4.566 E480G,E483A,K485A TPO183 TPO183 XRAY 4.047 0.227 0.26 A 540 459 0 0 0 0 [[27, 279]] 1.0 4rer CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
4REWA 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.282 14.445 None -106.98, -78.3 -79.98, 116.66 -98.66, 4.74 266.69, 106.69 -52.57, -49.44 out-out out 10.894 Saltbr-out 4.849 HRD-out -91.4, 104.28 -79.59, -35.51 out-in-out SNCoio in-out ActLoopNT-in 2.949 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -146.3, 177.71 APE9-dihe-na 92.22, 179.97 APE8-dihe-in -62.77, 176.84 APE8-rot-in 309.53 APE67-dihe-in -79.73, -37.36 -85.43, -26.86 APE12-dist-in 9.032 APE11-dist-in 10.912 APE10-dist-in 6.074 APE9-dist-out 7.166 E480G,E483A,K485A None None XRAY 4.58 0.234 0.259 A 540 411 0 0 0 0 [[27, 279]] 1.0 4rew CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
4REDA 22 360 559.0 No_ligand No_ligand Inactive DFGinter 7.587 8.711 None -76.34, -39.91 -91.25, 104.66 -101.3, 16.59 55.39, 86.7 124.85, -0.24 out-out out 12.796 Saltbr-out 10.996 HRD-out -68.9, 144.23 -138.95, 122.97 out-out-out SNCooo out-out ActLoopNT-out 13.073 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 59.47 APE8-rot-out 66.53 APE67-dihe-out -120.17, 127.81 -69.82, 149.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K52A None None XRAY 2.95 0.233 0.277 A 351 326 13 0 0 9 [[27, 279]] 1.0 4red CAMK_PRKAA1_HUMAN CAMK 4.9e-89 304.1 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
4REDB 22 360 559.0 No_ligand No_ligand Inactive DFGinter 7.581 8.224 None -76.53, -36.41 -94.12, 106.96 -98.58, 14.09 52.09, 86.12 121.55, -8.46 out-out out 12.669 Saltbr-out 11.179 HRD-out -67.54, 143.84 -139.21, 124.67 out-out-out SNCooo out-out ActLoopNT-out 13.157 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -40.52 APE8-rot-out 68.01 APE67-dihe-in -131.1, -88.72 -74.35, 44.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K52A None None XRAY 2.95 0.233 0.277 B 351 331 8 0 0 8 [[27, 279]] 1.0 4red CAMK_PRKAA1_HUMAN CAMK 4.9e-89 304.1 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1

CAMK_PRKAA1 (5'-AMP-activated protein kinase catalytic subunit alpha-1)

Total number of chains: 24
Active chains: 2
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 8 33.3% 6C9FA
DFGin BLAminus 7 29.2% AF-Q13131-K3A
DFGin None 7 29.2% 4CFHA
DFGinter None 2 8.3% 4REDB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AAPK1_HUMAN 6C9JA Q13131 22 559 559.0 R34:60601,STU:60602 Allosteric,Type1 Active DFGin 6.98 13.932 BLAminus -148.31, -179.86 61.68, 68.06 -82.96, 8.26 285.07, 89.54 -49.65, -37.12 out-in out 10.05 Saltbr-in 3.025 HRD-in -61.18, -61.45 68.18, -7.34 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.03, 155.55 APE9-dihe-na 81.79, 170.06 APE8-dihe-in -65.93, 140.22 APE8-rot-in 298.24 APE67-dihe-in -65.83, -31.14 -52.06, -38.38 APE12-dist-in 8.312 APE11-dist-in 11.199 APE10-dist-in 5.64 APE9-dist-in 4.101 None TPO183 TPO183 XRAY 3.05 0.215 0.225 A 494 384 0 0 0 0 [[27, 279]] 1.0 6c9j Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_HUMAN AF-Q13131-K3A Q13131 19 287 559.0 No_ligand No_ligand Active DFGin 6.501 14.903 BLAminus -129.08, -177.68 47.33, 68.2 -74.74, 17.85 288.58, 82.81 -63.19, -24.19 in-in in 9.323 Saltbr-in 2.709 HRD-in -78.49, -48.1 65.48, -2.12 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.89, 169.2 APE9-dihe-na 88.63, -177.87 APE8-dihe-in -80.88, 127.64 APE8-rot-in 293.69 APE67-dihe-in -63.96, -18.51 -42.59, -48.91 APE12-dist-in 8.22 APE11-dist-in 11.595 APE10-dist-in 6.089 APE9-dist-in 4.45 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[27, 279]] 1.0 AF-Q13131-K3 Homo sapiens CAMK_PRKAA1_HUMAN CAMK 5.5e-90 307.1 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_HUMAN 6C9FA Q13131 22 558 559.0 R34:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.728 14.295 ABAminus -116.49, -61.55 -94.26, 110.71 -99.52, 6.4 287.66, 85.72 -50.13, -39.13 out-out out 10.713 Saltbr-out 5.319 HRD-in -66.33, -58.11 53.99, 16.31 out-in-out SNCoio in-out ActLoopNT-in 2.771 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.89, 155.28 APE9-dihe-na 94.11, 171.31 APE8-dihe-in -69.7, 144.51 APE8-rot-out 175.9 APE67-dihe-in -64.59, -37.19 -54.17, -35.84 APE12-dist-in 8.268 APE11-dist-in 10.73 APE10-dist-in 5.149 APE9-dist-in 4.237 None TPO183 TPO183 XRAY 2.924 0.229 0.245 A 494 371 0 0 0 0 [[27, 279]] 1.0 6c9f Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_HUMAN 7JIJA Q13131 22 559 559.0 No_ligand No_ligand Inactive DFGin 8.307 13.768 ABAminus -95.45, -62.92 -74.4, 116.63 -122.62, 17.87 285.24, 153.02 -61.65, -40.14 out-in out 10.147 Saltbr-in 3.554 HRD-out -97.22, 118.75 -68.27, -49.38 in-in-in SNCiii in-in ActLoopNT-in 3.099 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.85, -164.16 APE9-dihe-na 97.91, 178.24 APE8-dihe-in -54.32, 146.84 APE8-rot-in 296.81 APE67-dihe-in -71.31, -40.54 -72.68, -33.78 APE12-dist-in 9.382 APE11-dist-in 11.619 APE10-dist-in 6.959 APE9-dist-in 5.882 None TPO183 TPO183 XRAY 5.5 0.253 0.323 A 484 407 0 0 0 0 [[27, 279]] 1.0 7jij Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_HUMAN 6C9GA Q13131 22 558 559.0 R93:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.907 14.399 BLAminus -135.02, 170.21 60.34, 77.63 -85.45, 11.43 285.05, 75.57 -50.8, -32.37 out-out out 10.695 Saltbr-out 5.597 HRD-in -79.11, -48.44 68.49, -16.14 out-in-out SNCoio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.15, 158.83 APE9-dihe-na 72.57, 174.42 APE8-dihe-in -69.04, 143.86 APE8-rot-out 162.73 APE67-dihe-in -62.81, -32.14 -55.18, -38.62 APE12-dist-in 8.45 APE11-dist-in 11.031 APE10-dist-in 6.008 APE9-dist-in 4.009 None TPO183 TPO183 XRAY 2.7 0.205 0.24 A 494 384 0 0 0 0 [[27, 279]] 1.0 6c9g Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_HUMAN 6C9HA Q13131 22 558 559.0 R34:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.712 14.382 BLAminus -138.26, 171.2 60.5, 73.75 -84.01, 6.76 285.61, 85.73 -48.49, -36.53 out-out out 10.649 Saltbr-out 5.631 HRD-in -69.22, -48.97 68.92, -5.29 out-in-out SNCoio in-out ActLoopNT-in 3.017 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.6, 158.62 APE9-dihe-na 60.32, -132.0 APE8-dihe-in -130.57, 153.41 APE8-rot-out 177.79 APE67-dihe-in -63.0, -34.49 -63.07, -41.05 APE12-dist-in 8.655 APE11-dist-in 10.618 APE10-dist-in 6.189 APE9-dist-in 3.873 None None None XRAY 2.65 0.215 0.242 A 494 433 0 0 0 0 [[27, 279]] 1.0 6c9h Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_HUMAN AF-Q13131-K1A Q13131 19 287 559.0 No_ligand No_ligand Inactive DFGin 6.939 14.365 BLAminus -126.29, 178.95 47.22, 74.39 -80.07, 15.61 284.51, 79.75 -61.56, -31.72 in-in in 9.375 Saltbr-in 2.671 HRD-in -78.83, -47.66 63.91, -0.09 in-in-out SNCiio in-out ActLoopNT-in 2.996 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.96, 168.44 APE9-dihe-na 93.06, 171.61 APE8-dihe-in -71.73, 134.73 APE8-rot-out 179.4 APE67-dihe-in -66.08, -18.64 -47.45, -46.11 APE12-dist-in 8.246 APE11-dist-in 11.392 APE10-dist-in 5.597 APE9-dist-in 3.639 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[27, 279]] 1.0 AF-Q13131-K1 Homo sapiens CAMK_PRKAA1_HUMAN CAMK 5.5e-90 307.1 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_HUMAN 7JHHA Q13131 22 559 559.0 No_ligand No_ligand Inactive DFGin 4.408 14.053 None -72.1, -47.74 -146.41, 153.99 -125.94, -39.52 58.73, 92.29 -80.39, -25.75 out-out out 12.69 Saltbr-out 12.814 HRD-out -119.19, 87.53 -68.79, -38.46 out-out-out SNCooo out-out ActLoopNT-out 5.3 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -67.5, -39.69 APE9-dihe-na -65.47, -47.47 APE8-dihe-in -135.51, 108.04 APE8-rot-in 295.83 APE67-dihe-in -65.04, -42.29 -74.22, -38.89 APE12-dist-in 11.962 APE11-dist-out 17.013 APE10-dist-out 19.009 APE9-dist-out 12.742 None None None EM 3.92 999.0 999.0 A 484 379 0 0 0 0 [[27, 279]] 1.0 7jhh Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_HUMAN 7JHGA Q13131 22 559 559.0 TAK:60601 Type1 Inactive DFGin 3.958 12.385 None -75.55, -57.95 -128.11, 115.65 -75.63, -58.59 53.99, 94.22 -113.12, -1.21 out-out out 12.413 Saltbr-out 12.276 HRD-out -118.93, 87.19 -68.87, -35.95 out-out-out SNCooo out-out ActLoopNT-out 5.755 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -71.04, -42.27 APE9-dihe-na -68.52, -40.55 APE8-dihe-in -128.24, 81.11 APE8-rot-out 178.77 APE67-dihe-in -67.22, -49.66 -68.38, -37.04 APE12-dist-in 12.585 APE11-dist-out 17.761 APE10-dist-out 17.985 APE9-dist-out 11.239 None None None EM 3.47 999.0 999.0 A 484 380 0 0 0 0 [[27, 279]] 1.0 7jhg Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_HUMAN 7M74A Q13131 22 559 559.0 TAK:60601 Type1 Inactive DFGin 4.811 13.234 None -76.76, -62.2 -122.49, 107.13 -85.46, -38.34 61.13, 92.05 -117.4, -4.69 out-out out 13.695 Saltbr-out 11.239 HRD-out -115.45, 89.03 -69.29, -34.6 out-out-out SNCooo out-out ActLoopNT-out 5.607 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -77.56, -39.26 APE9-dihe-na -72.79, -36.52 APE8-dihe-in -124.27, 83.8 APE8-rot-out 178.33 APE67-dihe-in -73.53, -46.6 -74.47, -34.26 APE12-dist-in 12.858 APE11-dist-out 17.936 APE10-dist-out 18.145 APE9-dist-out 11.108 None None None EM 3.93 999.0 999.0 A 484 380 0 0 0 0 [[27, 279]] 1.0 7m74 Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_HUMAN 4RERA Q13131 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.724 14.682 None -104.41, -74.44 -70.58, 123.21 -111.45, 7.12 271.34, 95.59 -64.34, -25.66 in-in in 9.394 Saltbr-in 3.168 HRD-out -106.73, 104.09 -76.93, -37.65 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.23, 162.43 APE9-dihe-na 109.76, -176.61 APE8-dihe-in -65.38, 159.16 APE8-rot-in 282.67 APE67-dihe-in -82.84, -28.7 -67.98, -40.26 APE12-dist-in 8.764 APE11-dist-in 11.102 APE10-dist-in 5.353 APE9-dist-in 4.566 E480G,E483A,K485A TPO183 TPO183 XRAY 4.047 0.227 0.26 A 540 459 0 0 0 0 [[27, 279]] 1.0 4rer Homo sapiens CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_HUMAN 4REWA Q13131 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.282 14.445 None -106.98, -78.3 -79.98, 116.66 -98.66, 4.74 266.69, 106.69 -52.57, -49.44 out-out out 10.894 Saltbr-out 4.849 HRD-out -91.4, 104.28 -79.59, -35.51 out-in-out SNCoio in-out ActLoopNT-in 2.949 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -146.3, 177.71 APE9-dihe-na 92.22, 179.97 APE8-dihe-in -62.77, 176.84 APE8-rot-in 309.53 APE67-dihe-in -79.73, -37.36 -85.43, -26.86 APE12-dist-in 9.032 APE11-dist-in 10.912 APE10-dist-in 6.074 APE9-dist-out 7.166 E480G,E483A,K485A None None XRAY 4.58 0.234 0.259 A 540 411 0 0 0 0 [[27, 279]] 1.0 4rew Homo sapiens CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_HUMAN 4REDA Q13131 22 360 559.0 No_ligand No_ligand Inactive DFGinter 7.587 8.711 None -76.34, -39.91 -91.25, 104.66 -101.3, 16.59 55.39, 86.7 124.85, -0.24 out-out out 12.796 Saltbr-out 10.996 HRD-out -68.9, 144.23 -138.95, 122.97 out-out-out SNCooo out-out ActLoopNT-out 13.073 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 59.47 APE8-rot-out 66.53 APE67-dihe-out -120.17, 127.81 -69.82, 149.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K52A None None XRAY 2.95 0.233 0.277 A 351 326 13 0 0 9 [[27, 279]] 1.0 4red Homo sapiens CAMK_PRKAA1_HUMAN CAMK 4.9e-89 304.1 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_HUMAN 4REDB Q13131 22 360 559.0 No_ligand No_ligand Inactive DFGinter 7.581 8.224 None -76.53, -36.41 -94.12, 106.96 -98.58, 14.09 52.09, 86.12 121.55, -8.46 out-out out 12.669 Saltbr-out 11.179 HRD-out -67.54, 143.84 -139.21, 124.67 out-out-out SNCooo out-out ActLoopNT-out 13.157 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -40.52 APE8-rot-out 68.01 APE67-dihe-in -131.1, -88.72 -74.35, 44.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K52A None None XRAY 2.95 0.233 0.277 B 351 331 8 0 0 8 [[27, 279]] 1.0 4red Homo sapiens CAMK_PRKAA1_HUMAN CAMK 4.9e-89 304.1 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_MOUSE 5UFUA Q5EG47 20 559 559.0 STU:60601,85V:60602 Type1,Allosteric Inactive DFGin 7.217 14.246 BLAminus -131.5, 162.6 65.85, 93.86 -99.38, 24.57 280.79, 65.36 -57.61, -46.84 in-in in 9.764 Saltbr-in 2.748 HRD-out -69.82, 100.36 -85.07, 166.65 in-in-out SNCiio in-out ActLoopNT-in 2.745 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -90.3, 155.77 APE9-dihe-na 100.05, 157.58 APE8-dihe-in -52.88, 143.31 APE8-rot-out 164.19 APE67-dihe-in -65.21, -41.11 -61.15, -33.48 APE12-dist-in 7.574 APE11-dist-in 11.095 APE10-dist-in 5.13 APE9-dist-out 6.066 None TPO183 TPO183 XRAY 3.45 0.195 0.238 A 503 249 0 0 0 0 [[27, 279]] 1.0 5ufu Mus musculus CAMK_PRKAA1_MOUSE CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 6E4TA P54645 20 559 559.0 HTV:60601,STU:60602 Allosteric,Type1 Inactive DFGin 7.435 14.261 ABAminus -127.14, -39.21 -103.64, 92.84 -85.31, 24.03 289.4, 72.26 -73.07, -34.04 out-in out 10.019 Saltbr-in 3.148 HRD-out -67.59, 99.51 -83.8, 164.42 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -86.15, 147.86 APE9-dihe-na 86.15, 170.33 APE8-dihe-in -53.88, 128.36 APE8-rot-out 178.71 APE67-dihe-in -78.32, -32.83 -55.05, -15.97 APE12-dist-in 7.737 APE11-dist-in 10.95 APE10-dist-in 5.108 APE9-dist-out 6.047 None TPO183 TPO183 XRAY 3.4 0.218 0.245 A 503 362 0 0 0 0 [[27, 279]] 1.0 6e4t Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 4QFGA P54645 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.531 14.834 ABAminus -129.83, -31.53 -108.51, 95.59 -86.54, 22.6 280.04, 73.48 -69.33, -40.23 in-in in 8.767 Saltbr-in 2.778 HRD-out -72.26, 87.26 -69.37, 157.2 in-in-in SNCiii in-in ActLoopNT-in 2.811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.6, 162.5 APE9-dihe-na 108.84, 159.63 APE8-dihe-in -59.24, 132.89 APE8-rot-in 308.45 APE67-dihe-in -56.78, -50.62 -41.69, -48.89 APE12-dist-in 7.804 APE11-dist-in 11.28 APE10-dist-in 5.635 APE9-dist-in 5.976 None TPO183 TPO183 XRAY 3.46 0.224 0.267 A 503 366 0 0 0 0 [[27, 279]] 1.0 4qfg Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 4QFRA P54645 20 559 559.0 STU:60601,32J:60606 Type1,Allosteric Inactive DFGin 7.179 14.461 ABAminus -135.94, -12.01 -110.66, 91.74 -85.33, 22.64 282.92, 78.98 -65.65, -45.25 in-in in 9.739 Saltbr-in 3.381 HRD-out -83.58, 90.91 -68.37, 165.86 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -94.98, 155.0 APE9-dihe-na 104.66, 160.03 APE8-dihe-in -55.29, 137.08 APE8-rot-out 167.48 APE67-dihe-in -71.49, -40.84 -60.68, -24.54 APE12-dist-in 7.624 APE11-dist-in 11.161 APE10-dist-in 5.181 APE9-dist-out 6.055 None TPO183 TPO183 XRAY 3.34 0.212 0.249 A 503 362 0 0 0 0 [[27, 279]] 1.0 4qfr Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 4QFSA P54645 20 559 559.0 STU:60601,32H:60602 Type1,Allosteric Inactive DFGin 6.89 14.377 ABAminus -124.9, -28.24 -112.18, 85.76 -75.27, 7.65 284.68, 79.39 -57.92, -39.76 in-in in 9.764 Saltbr-in 3.467 HRD-out -68.1, 87.64 -69.41, 154.35 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -125.95, 151.68 APE9-dihe-na 98.37, 158.77 APE8-dihe-in -43.48, 135.81 APE8-rot-out 168.88 APE67-dihe-in -73.46, -39.34 -64.14, -18.67 APE12-dist-in 7.721 APE11-dist-in 11.304 APE10-dist-in 5.545 APE9-dist-out 6.281 None TPO183 TPO183 XRAY 3.55 0.228 0.269 A 503 362 0 0 0 0 [[27, 279]] 1.0 4qfs Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 6E4UA P54645 20 559 559.0 STU:60601,HU7:60602 Type1,Allosteric Inactive DFGin 7.229 14.487 ABAminus -129.48, -32.52 -101.47, 99.32 -91.51, 18.06 282.35, 82.84 -62.17, -40.84 in-in in 9.777 Saltbr-in 2.9 HRD-out -78.35, 93.03 -70.69, 167.95 in-in-out SNCiio in-out ActLoopNT-in 2.908 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -104.64, -70.24 APE9-dihe-na -62.49, -169.58 APE8-dihe-in -69.59, 137.05 APE8-rot-out 166.67 APE67-dihe-in -62.15, -31.58 -48.72, -38.44 APE12-dist-in 7.888 APE11-dist-in 10.936 APE10-dist-in 5.302 APE9-dist-out 6.115 None TPO183 TPO183 XRAY 3.27 0.213 0.231 A 503 366 0 0 0 0 [[27, 279]] 1.0 6e4u Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 6E4WA P54645 20 559 559.0 STU:60601,HUG:60602 Type1,Allosteric Inactive DFGin 7.496 14.408 ABAminus -129.16, -43.82 -96.4, 98.46 -86.03, 19.41 285.3, 80.28 -65.13, -32.32 out-in out 10.281 Saltbr-in 3.414 HRD-out -66.89, 97.04 -81.94, 166.54 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -119.09, -68.02 APE9-dihe-na -76.27, -164.02 APE8-dihe-in -59.87, 132.49 APE8-rot-out 168.71 APE67-dihe-in -67.7, -51.69 -45.66, -33.67 APE12-dist-in 7.713 APE11-dist-in 10.871 APE10-dist-in 5.486 APE9-dist-out 6.081 None TPO183 TPO183 XRAY 3.35 0.21 0.244 A 503 362 0 0 0 0 [[27, 279]] 1.0 6e4w Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 5T5TA P54645 20 559 559.0 STU:60601 Type1 Inactive DFGin 7.275 14.446 BLAminus -131.93, 169.19 62.59, 84.7 -94.86, 17.97 279.02, 73.94 -55.16, -41.28 in-in in 9.798 Saltbr-in 3.171 HRD-out -77.74, 95.53 -76.17, 164.09 in-in-out SNCiio in-out ActLoopNT-in 2.838 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -99.9, 148.13 APE9-dihe-na 108.52, 171.16 APE8-dihe-in -60.68, 140.01 APE8-rot-out 180.44 APE67-dihe-in -65.41, -31.73 -60.15, -34.97 APE12-dist-in 7.797 APE11-dist-in 11.284 APE10-dist-in 5.316 APE9-dist-out 6.248 None TPO183 TPO183 XRAY 3.46 0.212 0.231 A 503 369 0 0 0 0 [[27, 279]] 1.0 5t5t Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 4CFHA P54645 21 481 559.0 STU:61550 Type1 Inactive DFGin 6.609 14.765 None -117.21, -79.88 -80.17, 112.56 -105.2, 27.91 278.75, 78.83 -62.93, -29.8 in-in in 9.294 Saltbr-in 2.664 HRD-out -123.7, 94.84 -71.28, 163.89 in-in-out SNCiio in-out ActLoopNT-in 3.029 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiio APE10-dihe-na -124.99, -9.44 APE9-dihe-na -61.07, -171.7 APE8-dihe-in -76.22, 167.06 APE8-rot-in 301.11 APE67-dihe-out -88.03, -177.87 -58.32, -48.27 APE12-dist-in 8.355 APE11-dist-in 10.864 APE10-dist-in 5.282 APE9-dist-out 6.078 None TPO183,TPO388 TPO183,TPO388 XRAY 3.24 0.234 0.268 A 493 402 0 0 0 0 [[27, 279]] 1.0 4cfh Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 5KQ5A P54645 21 559 559.0 STU:60601,6VT:60602 Type1,Allosteric Inactive DFGin 7.473 14.604 None -132.46, -37.52 -94.52, 85.46 -82.34, 16.94 281.45, 80.99 -67.49, -33.4 in-in in 9.898 Saltbr-in 3.252 HRD-out -71.96, 95.28 -74.85, 167.58 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -101.64, 146.06 APE9-dihe-na 119.59, 166.41 APE8-dihe-in -64.65, 139.74 APE8-rot-out 166.73 APE67-dihe-in -69.09, -28.51 -58.99, -33.91 APE12-dist-in 7.87 APE11-dist-in 11.359 APE10-dist-in 5.426 APE9-dist-out 6.076 None TPO183 TPO183 XRAY 3.41 0.223 0.259 A 503 363 0 0 0 0 [[27, 279]] 1.0 5kq5 Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1

CAMK_PRKAA1 (5'-AMP-activated protein kinase catalytic subunit alpha-1)

Total number of chains: 10
Active chains: 0
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 6 60.0% 6E4UA
DFGin BLAminus 2 20.0% 5UFUA
DFGin None 2 20.0% 4CFHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AAPK1_MOUSE 5UFUA Q5EG47 20 559 559.0 STU:60601,85V:60602 Type1,Allosteric Inactive DFGin 7.217 14.246 BLAminus -131.5, 162.6 65.85, 93.86 -99.38, 24.57 280.79, 65.36 -57.61, -46.84 in-in in 9.764 Saltbr-in 2.748 HRD-out -69.82, 100.36 -85.07, 166.65 in-in-out SNCiio in-out ActLoopNT-in 2.745 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -90.3, 155.77 APE9-dihe-na 100.05, 157.58 APE8-dihe-in -52.88, 143.31 APE8-rot-out 164.19 APE67-dihe-in -65.21, -41.11 -61.15, -33.48 APE12-dist-in 7.574 APE11-dist-in 11.095 APE10-dist-in 5.13 APE9-dist-out 6.066 None TPO183 TPO183 XRAY 3.45 0.195 0.238 A 503 249 0 0 0 0 [[27, 279]] 1.0 5ufu Mus musculus CAMK_PRKAA1_MOUSE CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 6E4TA P54645 20 559 559.0 HTV:60601,STU:60602 Allosteric,Type1 Inactive DFGin 7.435 14.261 ABAminus -127.14, -39.21 -103.64, 92.84 -85.31, 24.03 289.4, 72.26 -73.07, -34.04 out-in out 10.019 Saltbr-in 3.148 HRD-out -67.59, 99.51 -83.8, 164.42 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -86.15, 147.86 APE9-dihe-na 86.15, 170.33 APE8-dihe-in -53.88, 128.36 APE8-rot-out 178.71 APE67-dihe-in -78.32, -32.83 -55.05, -15.97 APE12-dist-in 7.737 APE11-dist-in 10.95 APE10-dist-in 5.108 APE9-dist-out 6.047 None TPO183 TPO183 XRAY 3.4 0.218 0.245 A 503 362 0 0 0 0 [[27, 279]] 1.0 6e4t Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 4QFGA P54645 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.531 14.834 ABAminus -129.83, -31.53 -108.51, 95.59 -86.54, 22.6 280.04, 73.48 -69.33, -40.23 in-in in 8.767 Saltbr-in 2.778 HRD-out -72.26, 87.26 -69.37, 157.2 in-in-in SNCiii in-in ActLoopNT-in 2.811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.6, 162.5 APE9-dihe-na 108.84, 159.63 APE8-dihe-in -59.24, 132.89 APE8-rot-in 308.45 APE67-dihe-in -56.78, -50.62 -41.69, -48.89 APE12-dist-in 7.804 APE11-dist-in 11.28 APE10-dist-in 5.635 APE9-dist-in 5.976 None TPO183 TPO183 XRAY 3.46 0.224 0.267 A 503 366 0 0 0 0 [[27, 279]] 1.0 4qfg Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 4QFRA P54645 20 559 559.0 STU:60601,32J:60606 Type1,Allosteric Inactive DFGin 7.179 14.461 ABAminus -135.94, -12.01 -110.66, 91.74 -85.33, 22.64 282.92, 78.98 -65.65, -45.25 in-in in 9.739 Saltbr-in 3.381 HRD-out -83.58, 90.91 -68.37, 165.86 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -94.98, 155.0 APE9-dihe-na 104.66, 160.03 APE8-dihe-in -55.29, 137.08 APE8-rot-out 167.48 APE67-dihe-in -71.49, -40.84 -60.68, -24.54 APE12-dist-in 7.624 APE11-dist-in 11.161 APE10-dist-in 5.181 APE9-dist-out 6.055 None TPO183 TPO183 XRAY 3.34 0.212 0.249 A 503 362 0 0 0 0 [[27, 279]] 1.0 4qfr Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 4QFSA P54645 20 559 559.0 STU:60601,32H:60602 Type1,Allosteric Inactive DFGin 6.89 14.377 ABAminus -124.9, -28.24 -112.18, 85.76 -75.27, 7.65 284.68, 79.39 -57.92, -39.76 in-in in 9.764 Saltbr-in 3.467 HRD-out -68.1, 87.64 -69.41, 154.35 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -125.95, 151.68 APE9-dihe-na 98.37, 158.77 APE8-dihe-in -43.48, 135.81 APE8-rot-out 168.88 APE67-dihe-in -73.46, -39.34 -64.14, -18.67 APE12-dist-in 7.721 APE11-dist-in 11.304 APE10-dist-in 5.545 APE9-dist-out 6.281 None TPO183 TPO183 XRAY 3.55 0.228 0.269 A 503 362 0 0 0 0 [[27, 279]] 1.0 4qfs Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 6E4UA P54645 20 559 559.0 STU:60601,HU7:60602 Type1,Allosteric Inactive DFGin 7.229 14.487 ABAminus -129.48, -32.52 -101.47, 99.32 -91.51, 18.06 282.35, 82.84 -62.17, -40.84 in-in in 9.777 Saltbr-in 2.9 HRD-out -78.35, 93.03 -70.69, 167.95 in-in-out SNCiio in-out ActLoopNT-in 2.908 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -104.64, -70.24 APE9-dihe-na -62.49, -169.58 APE8-dihe-in -69.59, 137.05 APE8-rot-out 166.67 APE67-dihe-in -62.15, -31.58 -48.72, -38.44 APE12-dist-in 7.888 APE11-dist-in 10.936 APE10-dist-in 5.302 APE9-dist-out 6.115 None TPO183 TPO183 XRAY 3.27 0.213 0.231 A 503 366 0 0 0 0 [[27, 279]] 1.0 6e4u Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 6E4WA P54645 20 559 559.0 STU:60601,HUG:60602 Type1,Allosteric Inactive DFGin 7.496 14.408 ABAminus -129.16, -43.82 -96.4, 98.46 -86.03, 19.41 285.3, 80.28 -65.13, -32.32 out-in out 10.281 Saltbr-in 3.414 HRD-out -66.89, 97.04 -81.94, 166.54 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -119.09, -68.02 APE9-dihe-na -76.27, -164.02 APE8-dihe-in -59.87, 132.49 APE8-rot-out 168.71 APE67-dihe-in -67.7, -51.69 -45.66, -33.67 APE12-dist-in 7.713 APE11-dist-in 10.871 APE10-dist-in 5.486 APE9-dist-out 6.081 None TPO183 TPO183 XRAY 3.35 0.21 0.244 A 503 362 0 0 0 0 [[27, 279]] 1.0 6e4w Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 5T5TA P54645 20 559 559.0 STU:60601 Type1 Inactive DFGin 7.275 14.446 BLAminus -131.93, 169.19 62.59, 84.7 -94.86, 17.97 279.02, 73.94 -55.16, -41.28 in-in in 9.798 Saltbr-in 3.171 HRD-out -77.74, 95.53 -76.17, 164.09 in-in-out SNCiio in-out ActLoopNT-in 2.838 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -99.9, 148.13 APE9-dihe-na 108.52, 171.16 APE8-dihe-in -60.68, 140.01 APE8-rot-out 180.44 APE67-dihe-in -65.41, -31.73 -60.15, -34.97 APE12-dist-in 7.797 APE11-dist-in 11.284 APE10-dist-in 5.316 APE9-dist-out 6.248 None TPO183 TPO183 XRAY 3.46 0.212 0.231 A 503 369 0 0 0 0 [[27, 279]] 1.0 5t5t Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 4CFHA P54645 21 481 559.0 STU:61550 Type1 Inactive DFGin 6.609 14.765 None -117.21, -79.88 -80.17, 112.56 -105.2, 27.91 278.75, 78.83 -62.93, -29.8 in-in in 9.294 Saltbr-in 2.664 HRD-out -123.7, 94.84 -71.28, 163.89 in-in-out SNCiio in-out ActLoopNT-in 3.029 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiio APE10-dihe-na -124.99, -9.44 APE9-dihe-na -61.07, -171.7 APE8-dihe-in -76.22, 167.06 APE8-rot-in 301.11 APE67-dihe-out -88.03, -177.87 -58.32, -48.27 APE12-dist-in 8.355 APE11-dist-in 10.864 APE10-dist-in 5.282 APE9-dist-out 6.078 None TPO183,TPO388 TPO183,TPO388 XRAY 3.24 0.234 0.268 A 493 402 0 0 0 0 [[27, 279]] 1.0 4cfh Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
AAPK1_RAT 5KQ5A P54645 21 559 559.0 STU:60601,6VT:60602 Type1,Allosteric Inactive DFGin 7.473 14.604 None -132.46, -37.52 -94.52, 85.46 -82.34, 16.94 281.45, 80.99 -67.49, -33.4 in-in in 9.898 Saltbr-in 3.252 HRD-out -71.96, 95.28 -74.85, 167.58 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -101.64, 146.06 APE9-dihe-na 119.59, 166.41 APE8-dihe-in -64.65, 139.74 APE8-rot-out 166.73 APE67-dihe-in -69.09, -28.51 -58.99, -33.91 APE12-dist-in 7.87 APE11-dist-in 11.359 APE10-dist-in 5.426 APE9-dist-out 6.076 None TPO183 TPO183 XRAY 3.41 0.223 0.259 A 503 363 0 0 0 0 [[27, 279]] 1.0 5kq5 Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1