TYR_MERTK (Tyrosine-protein kinase Mer)

Total number of chains: 67
Active chains: 2
Family: TYR
Uniprot: MERTK_HUMAN
Kinase Domain Residues: 587 - 856
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 22 32.8% 5U6CA
DFGin BLBplus 18 26.9% 7AVXA
DFGout None 7 10.4% 7AVXB
DFGin BLAminus 6 9.0% AF-Q12866-K1A
DFGout BBAminus 6 9.0% 7AAYA
DFGin BLBminus 5 7.5% 7AVYA
None None 2 3.0% 7OAMA
DFGin BLAplus 1 1.5% 7M5ZB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q12866-K1A 579 864 999.0 No_ligand No_ligand Active DFGin 6.586 13.681 BLAminus -144.83, -175.9 51.5, 82.73 -93.93, 18.27 304.69, 113.26 -60.03, -30.37 in-in in 8.204 Saltbr-in 2.676 HRD-in -74.47, -47.11 66.16, -5.81 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.85, 120.1 APE9-dihe-in -121.85, 147.61 APE8-dihe-in -75.14, 65.26 APE8-rot-na 35.08 APE67-dihe-in -70.89, -13.43 -42.81, -40.71 APE12-dist-na 13.782 APE11-dist-na 8.307 APE10-dist-na 10.592 APE9-dist-in 6.949 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[587, 856]] 1.0 AF-Q12866-K1 TYR_MERTK_HUMAN TYR 1e-92 316.1 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
AF-Q12866-K3A 579 864 999.0 No_ligand No_ligand Active DFGin 6.413 13.575 BLAminus -146.38, -177.24 51.16, 87.17 -97.96, 15.82 303.76, 108.44 -60.82, -30.58 in-in in 8.597 Saltbr-in 2.803 HRD-in -77.09, -48.52 64.93, -8.04 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.54, 129.1 APE9-dihe-in -135.06, 151.8 APE8-dihe-in -78.59, 66.92 APE8-rot-na 38.33 APE67-dihe-in -71.81, -12.29 -39.13, -41.1 APE12-dist-na 13.679 APE11-dist-na 7.977 APE10-dist-na 9.721 APE9-dist-in 6.224 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[587, 856]] 1.0 AF-Q12866-K3 TYR_MERTK_HUMAN TYR 1e-92 316.1 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AAZA 574 863 999.0 R6K:901 Type1.5_Front Inactive DFGin 6.931 13.0 BLAminus -138.31, -157.88 39.97, 76.8 -86.63, 13.92 303.38, 139.91 -55.98, -23.43 out-out out 13.714 Saltbr-out 13.412 HRD-in -73.08, -57.78 72.91, 6.58 out-in-out SNCoio in-out ActLoopNT-in 2.755 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -69.02, -26.36 APE9-dihe-in -66.36, 123.32 APE8-dihe-in -78.41, 127.1 APE8-rot-na 30.52 APE67-dihe-in -75.24, 0.32 -53.59, -39.62 APE12-dist-na 9.191 APE11-dist-na 11.609 APE10-dist-na 7.365 APE9-dist-in 4.907 None None None XRAY 1.855 0.189 0.219 A 296 290 0 0 0 0 [[587, 856]] 1.0 7aaz TYR_MERTK_HUMAN TYR 1.1e-92 315.9 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
9BHIA 578 864 999.0 A1APF:60901 Type1.5_Front Inactive DFGin 6.992 12.805 BLAminus -138.66, -158.87 44.96, 74.5 -90.39, 18.73 305.52, 137.7 -55.48, -30.3 out-out out 13.615 Saltbr-out 13.031 HRD-in -81.75, -51.8 68.35, 6.62 out-in-out SNCoio in-out ActLoopNT-in 2.82 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.15, 11.33 APE9-dihe-in -72.53, 150.77 APE8-dihe-in -64.75, 117.67 APE8-rot-na 25.92 APE67-dihe-in -73.91, -0.64 -53.67, -34.29 APE12-dist-na 7.154 APE11-dist-na 12.056 APE10-dist-na 11.657 APE9-dist-in 6.71 None None None XRAY 2.07 0.211 0.23 A 323 278 9 0 0 2 [[587, 856]] 1.0 9bhi TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
9BHJA 578 862 999.0 A1APG:60901 Type1.5_Front Inactive DFGin 7.068 13.244 BLAminus -146.72, -174.1 64.74, 69.57 -92.99, 18.47 306.82, 135.89 -58.57, -33.38 out-out out 13.147 Saltbr-out 13.083 HRD-in -74.38, -50.97 66.43, 4.8 out-in-out SNCoio in-out ActLoopNT-in 2.931 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -101.13, 12.6 APE9-dihe-in -72.99, 145.36 APE8-dihe-in -59.15, 119.95 APE8-rot-na 335.8 APE67-dihe-in -75.1, -1.94 -63.08, -26.94 APE12-dist-na 7.006 APE11-dist-na 11.862 APE10-dist-na 11.009 APE9-dist-in 6.692 None None None XRAY 2.294 0.22 0.252 A 323 279 6 0 0 0 [[587, 856]] 1.0 9bhj TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
9BHKA 578 862 999.0 A1APH:60901 Type1.5_Front Inactive DFGin 7.438 13.112 BLAminus -146.17, -169.74 58.59, 57.61 -88.08, 14.92 314.86, 133.55 -56.57, -30.36 out-out out 13.408 Saltbr-out 13.148 HRD-in -71.96, -51.79 69.44, 2.44 out-in-out SNCoio in-out ActLoopNT-in 2.846 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.49, 5.66 APE9-dihe-in -63.51, 142.65 APE8-dihe-in -57.87, 119.03 APE8-rot-na 336.99 APE67-dihe-in -73.75, -3.45 -57.71, -31.48 APE12-dist-na 7.129 APE11-dist-na 11.95 APE10-dist-na 11.013 APE9-dist-in 6.435 None None None XRAY 2.106 0.208 0.229 A 323 273 12 0 0 0 [[587, 856]] 1.0 9bhk TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7M5ZB 574 862 999.0 YR7:901 Type1 Inactive DFGin 5.838 12.524 BLAplus -159.53, -178.04 60.44, 58.46 -114.79, 14.1 33.64, 70.49 -51.9, 999.0 out-out out 13.751 Saltbr-out 12.154 HRD-in -66.18, -42.82 66.6, -11.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 46.45 APE8-rot-na 30.1 APE67-dihe-in -68.0, -31.03 -61.8, -27.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 3.06 0.265 0.297 B 313 264 25 0 0 19 [[587, 856]] 1.0 7m5z TYR_MERTK_HUMAN TYR 2.7e-92 314.7 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AVYA 576 863 999.0 S4E:901 Type1 Inactive DFGin 6.559 12.583 BLBminus -144.49, -173.14 43.51, 58.22 -65.27, 146.14 319.45, 104.85 -88.47, 168.4 out-out out 13.819 Saltbr-out 14.185 HRD-in -63.1, -54.14 77.2, -11.16 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 110.12 APE8-rot-na 25.31 APE67-dihe-in -73.48, -0.84 -44.31, -39.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.23 0.249 A 296 270 18 0 0 17 [[587, 856]] 1.0 7avy TYR_MERTK_HUMAN TYR 1.1e-92 315.9 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AW2A 571 862 999.0 S4W:60901 Type1.5_Front Inactive DFGin 6.721 12.964 BLBminus -150.9, -171.53 41.59, 54.7 -57.18, 136.95 317.76, 109.5 -43.48, 130.9 out-out out 12.917 Saltbr-out 13.1 HRD-in -73.03, -51.56 71.01, 1.22 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.98 APE8-rot-na 17.36 APE67-dihe-in -72.89, 2.66 -33.8, -45.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 2.1 0.208 0.238 A 298 267 25 0 0 18 [[587, 856]] 1.0 7aw2 TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7OLSA 571 862 999.0 VJZ:60901 Type1.5_Front Inactive DFGin 6.656 13.567 BLBminus -153.83, -175.53 51.86, 59.49 -72.66, 142.42 308.34, 110.17 -75.07, 999.0 out-out out 13.556 Saltbr-out 13.877 HRD-in -70.87, -52.35 83.16, -32.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.15 APE8-rot-na 35.66 APE67-dihe-in -76.51, -1.1 -58.07, -40.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.89 0.222 0.282 A 298 269 23 0 0 19 [[587, 856]] 1.0 7ols TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7OLVA 571 862 999.0 VK2:60901 Type1.5_Front Inactive DFGin 6.528 13.64 BLBminus -149.58, -174.75 55.04, 54.02 -65.24, 140.11 308.45, 116.95 -72.6, 999.0 out-out out 13.503 Saltbr-out 14.112 HRD-in -71.43, -46.21 70.23, 5.98 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 78.84 APE8-rot-na 31.04 APE67-dihe-in -72.99, -5.09 -55.61, -36.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 2.13 0.21 0.247 A 298 269 23 0 0 19 [[587, 856]] 1.0 7olv TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7OLXA 571 862 999.0 VK5:60901 Type1.5_Front Inactive DFGin 6.209 13.727 BLBminus -149.38, -179.13 56.05, 51.35 -58.87, 139.21 312.09, 118.2 -79.48, 999.0 out-out out 13.764 Saltbr-out 12.352 HRD-in -72.38, -52.17 78.72, -5.83 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 42.77 APE8-rot-na 35.47 APE67-dihe-in -74.39, -3.51 -55.36, -38.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.98 0.205 0.251 A 298 271 21 0 0 19 [[587, 856]] 1.0 7olx TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
2P0CA 575 861 999.0 ANP:1 ATPlike Inactive DFGin 5.924 13.136 BLBplus -137.27, 178.6 60.37, 23.32 -81.61, 167.49 49.71, 91.11 85.65, -47.4 out-none out 13.649 Saltbr-none 999.0 HRD-in -80.53, -55.62 75.56, -3.56 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.71 APE8-rot-na 32.28 APE67-dihe-in -80.87, -2.88 -33.63, -45.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.274 A 313 249 38 0 0 18 [[587, 856]] 1.0 2p0c TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
2P0CB 575 861 999.0 ANP:2 ATPlike Inactive DFGin 6.034 13.332 BLBplus -140.6, 176.88 63.43, 26.39 -92.68, 153.87 48.18, 81.79 87.34, -0.94 out-none out 13.973 Saltbr-none 999.0 HRD-in -83.37, -59.67 75.95, 2.32 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.74 APE8-rot-na 27.11 APE67-dihe-in -70.68, -3.16 -43.98, -45.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.274 B 313 248 39 0 0 18 [[587, 856]] 1.0 2p0c TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
3BRBA 575 861 999.0 ADP:901 ATPlike Inactive DFGin 6.074 13.609 BLBplus -149.4, 172.79 64.51, 33.37 -100.26, 164.7 46.71, 83.96 59.32, 174.03 out-out out 13.75 Saltbr-out 12.558 HRD-in -82.25, -54.47 71.68, 7.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -42.31 APE8-dihe-in -85.78, 61.15 APE8-rot-na 26.09 APE67-dihe-in -74.59, -1.92 -45.39, -40.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.341 None None None XRAY 1.9 0.195 0.24 A 313 260 27 0 0 16 [[587, 856]] 1.0 3brb TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
3BRBB 575 863 999.0 ADP:901 ATPlike Inactive DFGin 5.874 13.373 BLBplus -148.45, 175.8 65.39, 30.29 -97.01, 161.01 52.76, 80.7 77.95, 168.41 out-out out 13.696 Saltbr-out 12.572 HRD-in -83.14, -55.33 72.79, 2.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.74 APE8-rot-na 30.57 APE67-dihe-in -72.04, -6.33 -47.66, -41.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.195 0.24 B 313 271 18 0 0 18 [[587, 856]] 1.0 3brb TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7CQEA 578 861 999.0 YDJ:906 Type1 Inactive DFGin 5.694 12.457 BLBplus -152.24, -170.16 49.35, 41.77 -91.57, 97.57 44.58, 57.14 74.0, 999.0 out-out out 14.268 Saltbr-out 13.063 HRD-in -70.01, -64.83 84.53, -1.87 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 63.73 APE8-rot-na 37.9 APE67-dihe-in -78.04, -1.46 -58.17, -32.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.69 0.203 0.259 A 294 253 31 0 0 19 [[587, 856]] 1.0 7cqe TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7CQEC 578 861 999.0 YDJ:902 Type1 Inactive DFGin 6.41 13.001 BLBplus -154.28, -172.73 48.8, 38.59 -97.86, 95.79 39.92, 71.43 71.62, 999.0 out-out out 14.187 Saltbr-out 17.294 HRD-in -71.61, -64.11 82.96, 6.41 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.09 APE8-rot-na 37.08 APE67-dihe-in -77.01, -1.74 -56.95, -30.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.69 0.203 0.259 C 294 239 45 0 0 19 [[587, 856]] 1.0 7cqe TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7DXLA 575 863 999.0 E56:901 Type1 Inactive DFGin 5.693 12.912 BLBplus -151.73, -179.85 59.55, 33.96 -96.78, 141.17 48.03, 89.29 122.99, -141.2 out-out out 14.406 Saltbr-out 11.326 HRD-in -82.78, -46.78 71.1, -14.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.94 APE8-dihe-out -84.62, 44.17 APE8-rot-na 34.04 APE67-dihe-in -61.75, -10.77 -55.95, -44.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.781 I650M None None XRAY 3.146 0.259 0.302 A 296 261 28 0 0 17 [[587, 856]] 1.0 7dxl TYR_MERTK_HUMAN TYR 3.3e-92 314.4 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7DXLB 575 863 999.0 E56:901 Type1 Inactive DFGin 6.394 12.887 BLBplus -154.41, 174.83 65.7, 46.55 -105.06, 151.5 29.62, 85.97 72.51, 999.0 out-out out 13.873 Saltbr-out 12.938 HRD-in -88.29, -46.43 62.33, -8.53 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 12.68 APE8-rot-na 329.13 APE67-dihe-in -64.23, -9.78 -52.42, -47.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 I650M None None XRAY 3.146 0.259 0.302 B 296 256 33 0 0 19 [[587, 856]] 1.0 7dxl TYR_MERTK_HUMAN TYR 3.3e-92 314.4 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
3BPRA 575 863 999.0 OLP:900 Type1 Inactive DFGin 5.686 12.304 BLBplus -137.26, -178.9 61.47, 12.73 -59.75, 137.03 20.33, 65.08 61.12, -116.43 out-out out 12.689 Saltbr-out 10.364 HRD-in -72.21, -60.59 74.99, 6.41 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 8.66 APE8-rot-na 26.27 APE67-dihe-in -74.48, 0.97 -50.81, -38.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.275 0.301 A 313 261 28 0 0 17 [[587, 856]] 1.0 3bpr TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
3BPRB 576 863 999.0 OLP:900 Type1 Inactive DFGin 5.696 12.309 BLBplus -135.14, -179.32 61.21, 14.94 -59.61, 138.18 20.13, 67.44 59.61, -114.67 out-out out 12.681 Saltbr-out 10.349 HRD-in -67.36, -58.88 72.16, 7.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 9.65 APE8-rot-na 23.75 APE67-dihe-in -74.27, 0.34 -51.9, -37.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.275 0.301 B 313 256 32 0 0 17 [[587, 856]] 1.0 3bpr TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
3BPRC 575 863 999.0 OLP:900 Type1 Inactive DFGin 5.653 12.314 BLBplus -137.44, -178.75 62.53, 10.12 -55.95, 136.39 21.78, 66.13 60.87, -116.77 out-out out 12.661 Saltbr-out 10.357 HRD-in -72.44, -61.45 74.91, 7.03 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 10.43 APE8-rot-na 24.85 APE67-dihe-in -75.54, 1.55 -53.21, -36.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.275 0.301 C 313 259 30 0 0 17 [[587, 856]] 1.0 3bpr TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
3BPRD 575 863 999.0 OLP:900 Type1 Inactive DFGin 5.704 12.316 BLBplus -139.18, -179.69 62.54, 13.28 -60.89, 135.81 20.55, 64.95 61.8, -113.74 out-out out 12.676 Saltbr-out 10.399 HRD-in -70.76, -61.42 73.63, 7.99 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 10.06 APE8-rot-na 25.2 APE67-dihe-in -76.88, 1.13 -52.53, -35.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.275 0.301 D 313 259 30 0 0 17 [[587, 856]] 1.0 3bpr TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
4M3QB 577 861 999.0 24K:904 Type1 Inactive DFGin 7.016 12.844 BLBplus -155.47, 177.8 59.97, 60.05 -123.11, 100.7 28.76, 84.8 73.7, 999.0 out-out out 13.113 Saltbr-out 8.269 HRD-in -77.58, -49.58 67.43, 9.99 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -8.23 APE8-rot-na 30.54 APE67-dihe-in -76.7, 7.19 -63.08, -36.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.718 0.248 0.296 B 313 236 49 0 0 19 [[587, 856]] 1.0 4m3q TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
4MHAA 580 863 999.0 4MH:904 Type1 Inactive DFGin 6.066 12.879 BLBplus -165.26, -177.42 65.13, 22.57 -85.11, 109.86 39.34, 89.59 -64.37, 999.0 out-out out 13.26 Saltbr-out 11.617 HRD-in -90.76, -48.14 63.93, 14.2 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 53.04 APE8-rot-na 30.98 APE67-dihe-in -69.86, -11.05 -63.45, -33.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.59 0.246 0.294 A 313 256 28 0 0 19 [[587, 856]] 1.0 4mha TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
5K0KA 577 863 999.0 6Q1:904 Type1 Inactive DFGin 6.043 13.083 BLBplus -151.37, 176.9 70.65, 6.45 -74.59, 148.34 49.33, 80.56 71.75, 161.84 out-out out 13.206 Saltbr-out 9.664 HRD-in -93.56, -51.52 71.26, 5.04 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 31.89 APE8-rot-na 27.0 APE67-dihe-in -74.95, 2.1 -52.33, -38.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.545 0.203 0.254 A 313 260 27 0 0 18 [[587, 856]] 1.0 5k0k TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
5K0XA 576 863 999.0 K0X:904 Type1 Inactive DFGin 6.004 13.123 BLBplus -141.68, 176.73 63.1, 26.77 -84.66, 126.17 47.94, 79.86 81.45, 999.0 out-out out 13.512 Saltbr-out 10.996 HRD-in -92.4, -57.41 77.73, 0.87 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -7.87 APE8-rot-na 21.82 APE67-dihe-in -69.98, -2.36 -41.05, -51.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.231 0.189 0.239 A 313 258 30 0 0 19 [[587, 856]] 1.0 5k0x TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
6MEPA 576 863 999.0 9VS:904 Type1.5_Back Inactive DFGin 6.881 13.685 BLBplus -143.01, -178.51 63.28, 31.36 -107.1, 128.61 51.55, 95.48 90.53, 175.14 out-out out 13.538 Saltbr-out 11.985 HRD-out -104.28, 87.47 -74.97, 17.26 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 63.86 APE8-rot-na 29.86 APE67-dihe-in -73.9, 3.63 -75.19, -36.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.893 0.21 0.268 A 313 250 38 0 0 17 [[587, 856]] 1.0 6mep TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AVXA 577 862 999.0 S4K:901 Type1.5_Front Inactive DFGin 6.212 14.187 BLBplus -139.94, 176.96 57.63, 33.7 -91.93, 149.58 50.89, 81.01 -76.42, 165.87 out-out out 12.696 Saltbr-out 9.191 HRD-in -70.33, -65.18 70.62, 12.45 out-out-out SNCooo out-out ActLoopNT-out 5.197 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -81.78, -23.56 APE9-dihe-in -75.41, 164.94 APE8-dihe-in -70.62, 164.17 APE8-rot-na 350.35 APE67-dihe-in -69.09, -9.08 -44.67, -43.43 APE12-dist-na 13.398 APE11-dist-na 14.161 APE10-dist-na 11.783 APE9-dist-in 4.623 None None None XRAY 2.44 0.216 0.259 A 313 276 10 0 0 5 [[587, 856]] 1.0 7avx TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
5TD2B 577 861 999.0 No_ligand No_ligand Inactive DFGin 6.793 13.116 None -144.11, 174.62 61.92, 63.15 -77.51, 999.0 303.45, 94.64 999.0, 999.0 out-out out 13.351 Saltbr-out 12.416 HRD-in -68.4, -50.94 72.94, 5.34 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 75.34 APE8-rot-na 32.97 APE67-dihe-in -69.61, -9.75 -67.34, -19.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.68 0.251 0.3 B 285 242 43 0 0 20 [[587, 856]] 1.0 5td2 TYR_MERTK_HUMAN TYR 2.9e-92 314.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
4MH7B 577 862 999.0 No_ligand No_ligand Inactive DFGin 6.237 12.808 None -148.47, -179.73 64.64, 46.7 -122.89, 999.0 48.11, 70.87 999.0, 999.0 out-out out 12.896 Saltbr-out 12.926 HRD-in -78.94, -52.07 71.09, 5.48 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 23.45 APE8-rot-na 30.55 APE67-dihe-in -77.17, 1.49 -58.85, -30.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.51 0.228 0.279 B 313 255 31 0 0 20 [[587, 856]] 1.0 4mh7 TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
5TC0B 578 861 999.0 No_ligand No_ligand Inactive DFGin 5.977 12.879 None -140.01, 177.82 66.06, 34.51 -92.54, 999.0 25.62, 68.77 999.0, 999.0 out-out out 12.95 Saltbr-out 9.125 HRD-in -84.36, -52.52 74.32, 6.07 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -24.67 APE8-rot-na 31.87 APE67-dihe-in -69.09, -5.19 -56.41, -41.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.24 0.229 0.262 B 314 250 34 0 0 20 [[587, 856]] 1.0 5tc0 TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AB0A 571 862 999.0 No_ligand No_ligand Inactive DFGin 6.624 14.014 None -143.7, 175.11 61.44, 47.67 -68.22, 999.0 316.54, 102.57 999.0, 999.0 out-out out 13.264 Saltbr-out 14.346 HRD-in -75.07, -54.59 74.43, 4.28 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.53 APE8-rot-na 33.09 APE67-dihe-in -75.24, -3.15 -51.47, -40.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.74 0.202 0.246 A 298 267 25 0 0 20 [[587, 856]] 1.0 7ab0 TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
5TD2A 577 861 999.0 7AE:1000 Type1 Inactive DFGin 6.134 13.651 None -143.3, 174.43 65.95, 82.51 -104.11, 999.0 312.2, 105.07 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.96, -51.07 72.28, 6.41 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 97.89 APE8-rot-na 25.82 APE67-dihe-in -75.54, -1.44 -65.62, -42.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.68 0.251 0.3 A 285 240 45 0 0 20 [[587, 856]] 1.0 5td2 TYR_MERTK_HUMAN TYR 2.9e-92 314.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7OAMB 576 862 999.0 V6H:60901 Type1 Inactive DFGin 7.007 13.457 None -146.0, 178.63 58.31, 50.5 -120.77, 999.0 46.98, 69.39 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.67, -62.84 85.61, -10.13 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 97.98 APE8-dihe-in -79.78, 85.21 APE8-rot-na 33.46 APE67-dihe-in -75.72, -1.35 -61.95, -25.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.518 None None None XRAY 2.65 0.224 0.257 B 296 250 37 0 0 19 [[587, 856]] 1.0 7oam TYR_MERTK_HUMAN TYR 1.1e-92 315.9 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
3TCPA 577 863 999.0 CKJ:1 Type1 Inactive DFGin 6.203 12.893 None -136.14, -178.38 58.94, 40.23 -104.0, 999.0 45.8, 90.86 999.0, 999.0 out-out out 13.07 Saltbr-out 10.087 HRD-in -71.3, -54.4 78.76, -16.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 71.51 APE8-rot-na 24.96 APE67-dihe-in -68.45, -1.97 -46.97, -39.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.69 0.228 0.298 A 313 256 31 0 0 20 [[587, 856]] 1.0 3tcp TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
3TCPB 576 861 999.0 CKJ:2 Type1 Inactive DFGin 6.542 12.725 None -151.12, -175.9 57.3, 28.48 -93.29, 999.0 44.8, 72.64 999.0, 999.0 out-none out 12.011 Saltbr-none 999.0 HRD-in -62.48, -45.95 68.1, -10.21 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -34.04 APE8-dihe-in -94.24, 71.38 APE8-rot-na 31.8 APE67-dihe-in -76.89, -2.28 -48.4, -36.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.261 None None None XRAY 2.69 0.228 0.298 B 313 250 36 0 0 19 [[587, 856]] 1.0 3tcp TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
4M3QA 578 861 999.0 24K:906 Type1 Inactive DFGin 5.962 13.272 None -156.18, 179.21 59.94, 63.59 -121.26, 999.0 26.4, 60.96 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -76.83, -49.1 68.2, 10.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -8.28 APE8-rot-na 30.83 APE67-dihe-in -76.46, 5.82 -62.87, -37.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.718 0.248 0.296 A 313 243 41 0 0 20 [[587, 856]] 1.0 4m3q TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
4MH7A 577 861 999.0 MH7:906 Type1 Inactive DFGin 6.673 13.733 None -149.88, -177.32 66.64, 46.5 -124.55, 999.0 44.22, 68.98 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -78.51, -51.41 72.09, 3.88 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 23.58 APE8-rot-na 30.75 APE67-dihe-in -78.5, 1.01 -58.56, -31.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.51 0.228 0.279 A 313 248 37 0 0 20 [[587, 856]] 1.0 4mh7 TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
4MHAB 577 862 999.0 4MH:905 Type1 Inactive DFGin 5.588 13.166 None -164.91, -178.11 62.75, 50.05 -120.6, 999.0 47.74, 75.91 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -87.47, -43.02 65.67, 7.44 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 102.4 APE8-rot-na 29.27 APE67-dihe-in -76.83, 2.21 -113.8, -35.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.59 0.246 0.294 B 313 246 40 0 0 20 [[587, 856]] 1.0 4mha TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
5K0KB 577 862 999.0 6Q1:904 Type1 Inactive DFGin 6.189 13.389 None -144.02, -179.34 56.66, 60.57 -135.11, 999.0 52.83, 74.37 999.0, 999.0 out-out out 12.83 Saltbr-out 9.006 HRD-in -81.18, -49.68 74.51, -7.68 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.62 APE8-rot-na 27.52 APE67-dihe-in -73.94, -3.99 -57.79, -40.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.545 0.203 0.254 B 313 248 38 0 0 20 [[587, 856]] 1.0 5k0k TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
5TC0A 578 861 999.0 79Y:1100 Type1 Inactive DFGin 5.868 13.093 None -140.95, 176.68 72.06, 53.5 -127.68, 999.0 35.95, 63.07 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -85.04, -52.33 70.75, 9.58 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 51.99 APE8-dihe-in -70.22, 110.63 APE8-rot-na 29.77 APE67-dihe-in -71.61, -2.78 -54.4, -35.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.184 None None None XRAY 2.24 0.229 0.262 A 314 238 46 0 0 19 [[587, 856]] 1.0 5tc0 TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
5U6CA 572 864 999.0 7YS:9001 Type1 Inactive DFGin 6.514 13.097 None -140.41, -178.19 73.14, -58.25 59.05, 38.04 321.05, 119.16 47.3, 38.19 out-out out 12.238 Saltbr-out 10.41 HRD-in -76.31, -59.9 77.64, -5.13 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -19.89 APE8-rot-na 24.77 APE67-dihe-in -66.57, -0.63 -47.81, -46.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.214 0.257 A 315 272 21 0 0 17 [[587, 856]] 1.0 5u6c TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
5U6CB 575 862 999.0 7YS:9001 Type1 Inactive DFGin 5.756 13.39 None -146.75, -178.14 49.0, 37.86 -93.39, 999.0 43.6, 77.83 999.0, 999.0 out-out out 13.856 Saltbr-out 11.107 HRD-in -77.29, -57.91 76.71, -6.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 163.75 APE8-dihe-in -83.33, 57.19 APE8-rot-na 31.94 APE67-dihe-in -71.79, -2.99 -38.38, -48.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.061 None None None XRAY 2.1 0.214 0.257 B 315 257 31 0 0 19 [[587, 856]] 1.0 5u6c TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AB1A 571 862 999.0 C6F:60901 Type1 Inactive DFGin 5.872 13.527 None -150.27, 178.21 48.78, 48.66 -107.87, 999.0 41.9, 85.18 999.0, 999.0 out-out out 12.844 Saltbr-out 9.566 HRD-in -84.92, -52.07 85.67, -41.55 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.29 APE8-rot-na 36.31 APE67-dihe-in -65.53, -14.5 -57.08, -42.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.93 0.237 0.298 A 298 267 25 0 0 20 [[587, 856]] 1.0 7ab1 TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AB2A 571 862 999.0 R6N:60901 Type1 Inactive DFGin 6.328 13.588 None -148.22, 175.53 55.93, 53.34 -74.83, 999.0 329.09, 104.95 999.0, 999.0 out-out out 13.203 Saltbr-out 14.57 HRD-in -79.16, -56.47 81.41, -4.68 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 64.62 APE8-rot-na 36.54 APE67-dihe-in -78.04, -6.9 -58.38, -34.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.78 0.196 0.25 A 298 267 25 0 0 20 [[587, 856]] 1.0 7ab2 TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AVZA 571 862 999.0 S4N:60901 Type1 Inactive DFGin 6.269 13.59 None -145.45, 176.2 52.56, 50.67 -72.23, 999.0 339.86, 87.13 999.0, 999.0 out-out out 12.984 Saltbr-out 9.923 HRD-in -69.09, -58.13 78.41, -16.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -7.96 APE8-rot-na 31.06 APE67-dihe-in -76.22, 2.71 -47.31, -44.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 2.04 0.207 0.229 A 298 265 27 0 0 20 [[587, 856]] 1.0 7avz TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AW0A 571 862 999.0 S4Q:60901 Type1 Inactive DFGin 6.074 13.887 None -146.33, 175.15 58.08, 44.92 -106.5, 999.0 37.04, 79.3 999.0, 999.0 out-out out 13.159 Saltbr-out 9.893 HRD-in -73.83, -55.86 76.62, -13.66 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 69.76 APE8-rot-na 19.28 APE67-dihe-in -68.82, -6.08 -45.38, -39.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.893 0.204 0.233 A 298 266 26 0 0 20 [[587, 856]] 1.0 7aw0 TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AW3A 571 862 999.0 S4Z:60901 Type1 Inactive DFGin 6.136 13.492 None -141.96, 175.75 54.61, 48.83 -104.75, 999.0 29.07, 73.23 999.0, 999.0 out-out out 13.253 Saltbr-out 10.167 HRD-in -76.56, -55.94 78.32, -15.64 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.13 APE8-rot-na 30.36 APE67-dihe-in -72.86, -3.93 -46.59, -40.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.99 0.217 0.245 A 298 266 26 0 0 20 [[587, 856]] 1.0 7aw3 TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7M5ZA 577 862 999.0 YR7:901 Type1 Inactive DFGin 5.681 14.174 None -159.0, -169.59 47.7, 65.14 -69.86, 999.0 300.1, 112.68 999.0, 999.0 in-out in 9.256 Saltbr-out 6.024 HRD-in -77.96, -43.12 69.37, -0.08 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 13.83 APE8-rot-na 32.06 APE67-dihe-in -66.59, -6.13 -57.74, -32.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 3.06 0.265 0.297 A 313 263 23 0 0 20 [[587, 856]] 1.0 7m5z TYR_MERTK_HUMAN TYR 2.7e-92 314.7 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
6MEPB 578 862 999.0 9VS:904 Type1.5_Back Inactive DFGin 6.137 13.751 None -149.56, -177.34 59.65, 39.31 -110.56, 999.0 52.79, 83.98 999.0, 999.0 out-out out 12.835 Saltbr-out 11.807 HRD-out -99.49, 96.49 -80.13, -3.87 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 68.16 APE8-rot-na 30.37 APE67-dihe-in -67.86, -3.3 -78.71, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.893 0.21 0.268 B 313 236 49 0 0 20 [[587, 856]] 1.0 6mep TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
9KS9B 577 863 999.0 A1L6L:901 Type1 Inactive DFGout 16.68 9.571 BBAminus -150.93, -175.1 -149.15, 104.97 -55.25, -29.1 282.42, 72.66 68.42, 999.0 out-none out 12.294 Saltbr-none 999.0 HRD-in -61.19, -61.05 76.89, -1.4 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 45.22 APE8-rot-na 27.27 APE67-dihe-in -61.05, -25.0 -62.95, -42.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.212 0.26 B 294 259 28 0 0 19 [[587, 856]] 1.0 9ks9 TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7XHYA 571 862 999.0 E0X:60901 Type1 Inactive DFGout 16.043 9.147 BBAminus -145.7, -173.77 -157.94, 107.94 -59.29, -23.23 277.42, 83.07 47.74, 57.36 out-out out 13.309 Saltbr-out 10.486 HRD-in -73.65, -57.9 79.12, -8.03 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 28.15 APE8-rot-na 34.93 APE67-dihe-in -74.84, -2.33 -55.6, -34.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 2.16 0.212 0.252 A 298 267 25 0 0 18 [[587, 856]] 1.0 7xhy TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AAYA 571 862 999.0 L1X:60901 Type2 Inactive DFGout 15.272 11.553 BBAminus -158.07, -174.81 -144.2, 119.75 -72.18, -30.61 282.04, 79.68 81.94, 999.0 in-in in 8.727 Saltbr-in 2.808 HRD-in -70.71, -62.02 81.51, -21.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -56.79 APE8-dihe-out -51.76, -19.75 APE8-rot-na 333.06 APE67-dihe-in -71.89, -3.89 -51.82, -34.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.661 None None None XRAY 1.87 0.197 0.224 A 294 270 18 0 0 18 [[587, 856]] 1.0 7aay TYR_MERTK_HUMAN TYR 5.3e-93 317.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
9KRYB 580 863 999.0 A1L6J:901 Type2 Inactive DFGout 16.962 9.427 BBAminus -147.28, -173.49 -155.52, 108.98 -61.25, -61.35 276.25, 91.0 70.46, 26.54 out-none out 13.103 Saltbr-none 999.0 HRD-in -73.14, -53.57 69.92, -2.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.5 APE8-rot-na 26.98 APE67-dihe-in -76.71, -9.16 -55.23, -33.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.242 0.284 B 294 252 32 0 0 18 [[587, 856]] 1.0 9kry TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AW4A 576 862 999.0 S5E:901 Type3 Inactive DFGout 14.166 6.988 BBAminus -151.73, 174.5 -134.58, 93.64 -99.75, 11.14 282.83, 106.8 -60.06, 134.62 out-out out 12.678 Saltbr-out 6.924 HRD-in -71.68, -56.26 76.66, -5.4 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 37.4 APE8-rot-na 27.32 APE67-dihe-in -72.74, -3.62 -49.0, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.98 0.215 0.246 A 313 264 23 0 0 17 [[587, 856]] 1.0 7aw4 TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AW4B 574 862 999.0 S5E:901 Type3 Inactive DFGout 14.17 7.002 BBAminus -152.39, 174.35 -134.62, 92.94 -100.47, 8.02 282.22, 107.21 -60.15, 130.28 out-out out 12.756 Saltbr-out 7.104 HRD-in -72.36, -56.01 76.07, -4.93 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 37.48 APE8-rot-na 27.51 APE67-dihe-in -72.81, -3.1 -48.72, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.98 0.215 0.246 B 313 257 32 0 0 18 [[587, 856]] 1.0 7aw4 TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AVXB 577 862 999.0 S4K:901 Type1 Inactive DFGout 16.233 9.367 None -141.54, -179.69 -114.73, -166.9 -158.87, 999.0 260.93, 100.77 999.0, 999.0 out-out out 12.963 Saltbr-out 9.387 HRD-in -69.0, -65.55 71.08, 10.89 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.94 APE8-rot-na 24.19 APE67-dihe-in -68.67, -9.11 -43.26, -44.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.44 0.216 0.259 B 313 263 23 0 0 20 [[587, 856]] 1.0 7avx TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
9KRZA 577 864 999.0 A1L6K:901 Type1.5_Front Inactive DFGout 16.995 9.166 None -144.96, 178.8 -147.12, 97.05 -55.74, 999.0 272.88, 54.11 999.0, 999.0 out-none out 12.645 Saltbr-none 999.0 HRD-in -83.04, -57.33 76.85, -1.67 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 22.11 APE8-rot-na 9.43 APE67-dihe-in -73.23, -7.29 -55.21, -31.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.224 0.267 A 294 263 25 0 0 20 [[587, 856]] 1.0 9krz TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
9KRZB 575 863 999.0 A1L6K:901 Type1.5_Front Inactive DFGout 17.116 9.26 None -136.76, -173.26 -147.11, 97.01 -63.71, 999.0 262.09, 109.75 999.0, 999.0 out-none out 12.404 Saltbr-none 999.0 HRD-in -59.48, -61.4 74.72, -1.69 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.37 APE8-rot-na 32.13 APE67-dihe-in -79.29, -5.37 -59.11, -19.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.224 0.267 B 294 260 29 0 0 20 [[587, 856]] 1.0 9krz TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
9KRYA 580 863 999.0 A1L6J:901 Type2 Inactive DFGout 16.021 9.312 None -145.17, -171.5 -155.53, 115.18 -76.36, 999.0 280.47, 88.85 999.0, 999.0 out-out out 10.614 Saltbr-out 4.668 HRD-in -79.08, -57.6 74.04, -4.61 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 14.81 APE8-rot-na 349.6 APE67-dihe-in -82.44, -0.93 -60.68, -30.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.242 0.284 A 294 249 35 0 0 20 [[587, 856]] 1.0 9kry TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
9KS9A 576 862 999.0 A1L6L:1001 Type2 Inactive DFGout 15.524 9.27 None -150.99, -177.04 -153.01, 113.06 -69.38, 999.0 286.5, 79.65 999.0, 999.0 out-out out 10.161 Saltbr-out 4.673 HRD-in -73.1, -59.19 76.81, -1.34 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 25.41 APE8-rot-na 29.26 APE67-dihe-in -77.0, -9.07 -59.08, -33.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.212 0.26 A 294 262 25 0 0 20 [[587, 856]] 1.0 9ks9 TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AAXA 571 862 999.0 R6H:60901 Type2 Inactive DFGout 15.733 8.907 None -138.81, -167.54 -165.53, 104.61 -69.55, 999.0 281.2, 84.02 999.0, 999.0 out-out out 12.981 Saltbr-out 13.872 HRD-in -71.43, -58.84 84.16, -7.62 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 9.57 APE8-rot-na 34.0 APE67-dihe-in -78.18, -0.39 -55.56, -36.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.762 0.202 0.253 A 298 267 25 0 0 20 [[587, 856]] 1.0 7aax TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7AW1A 571 862 999.0 S4T:60901 Type2 Inactive DFGout 16.346 9.562 None -147.65, -171.05 -165.02, 92.03 -50.93, 999.0 282.63, 88.85 999.0, 999.0 out-out out 13.311 Saltbr-out 10.463 HRD-in -79.03, -54.45 77.4, -8.22 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 60.11 APE8-rot-na 28.27 APE67-dihe-in -65.96, -9.73 -45.0, -44.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.98 0.203 0.225 A 298 265 27 0 0 20 [[587, 856]] 1.0 7aw1 TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
7OAMA 575 863 999.0 No_ligand No_ligand Inactive None 999.0 999.0 None -144.87, 174.24 51.78, 47.89 113.25, 999.0 999.0, 999.0 999.0, 999.0 out-none out 13.006 Saltbr-none 999.0 HRD-in -73.54, -63.06 83.28, -5.74 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.53 APE8-dihe-in -87.85, 50.31 APE8-rot-na 32.97 APE67-dihe-in -74.96, -1.44 -63.88, -24.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.315 None None None XRAY 2.65 0.224 0.257 A 296 260 29 0 0 19 [[587, 856]] 1.0 7oam TYR_MERTK_HUMAN TYR 1.1e-92 315.9 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
5K0XB 575 863 999.0 K0X:903 Type1 Inactive None 999.0 999.0 None -144.28, -179.95 63.63, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 13.28 Saltbr-out 11.559 HRD-in -82.77, -56.55 75.35, 0.54 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 69.74 APE8-rot-na 36.04 APE67-dihe-in -72.66, -3.44 -60.52, -36.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.231 0.189 0.239 B 313 254 35 0 0 21 [[587, 856]] 1.0 5k0x TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer

TYR_MERTK (Tyrosine-protein kinase Mer)

Total number of chains: 67
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 22 32.8% 5U6CA
DFGin BLBplus 18 26.9% 7AVXA
DFGout None 7 10.4% 7AVXB
DFGin BLAminus 6 9.0% AF-Q12866-K1A
DFGout BBAminus 6 9.0% 7AAYA
DFGin BLBminus 5 7.5% 7AVYA
None None 2 3.0% 7OAMA
DFGin BLAplus 1 1.5% 7M5ZB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MERTK_HUMAN AF-Q12866-K1A Q12866 579 864 999.0 No_ligand No_ligand Active DFGin 6.586 13.681 BLAminus -144.83, -175.9 51.5, 82.73 -93.93, 18.27 304.69, 113.26 -60.03, -30.37 in-in in 8.204 Saltbr-in 2.676 HRD-in -74.47, -47.11 66.16, -5.81 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.85, 120.1 APE9-dihe-in -121.85, 147.61 APE8-dihe-in -75.14, 65.26 APE8-rot-na 35.08 APE67-dihe-in -70.89, -13.43 -42.81, -40.71 APE12-dist-na 13.782 APE11-dist-na 8.307 APE10-dist-na 10.592 APE9-dist-in 6.949 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[587, 856]] 1.0 AF-Q12866-K1 Homo sapiens TYR_MERTK_HUMAN TYR 1e-92 316.1 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN AF-Q12866-K3A Q12866 579 864 999.0 No_ligand No_ligand Active DFGin 6.413 13.575 BLAminus -146.38, -177.24 51.16, 87.17 -97.96, 15.82 303.76, 108.44 -60.82, -30.58 in-in in 8.597 Saltbr-in 2.803 HRD-in -77.09, -48.52 64.93, -8.04 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.54, 129.1 APE9-dihe-in -135.06, 151.8 APE8-dihe-in -78.59, 66.92 APE8-rot-na 38.33 APE67-dihe-in -71.81, -12.29 -39.13, -41.1 APE12-dist-na 13.679 APE11-dist-na 7.977 APE10-dist-na 9.721 APE9-dist-in 6.224 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[587, 856]] 1.0 AF-Q12866-K3 Homo sapiens TYR_MERTK_HUMAN TYR 1e-92 316.1 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AAZA Q12866 574 863 999.0 R6K:901 Type1.5_Front Inactive DFGin 6.931 13.0 BLAminus -138.31, -157.88 39.97, 76.8 -86.63, 13.92 303.38, 139.91 -55.98, -23.43 out-out out 13.714 Saltbr-out 13.412 HRD-in -73.08, -57.78 72.91, 6.58 out-in-out SNCoio in-out ActLoopNT-in 2.755 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -69.02, -26.36 APE9-dihe-in -66.36, 123.32 APE8-dihe-in -78.41, 127.1 APE8-rot-na 30.52 APE67-dihe-in -75.24, 0.32 -53.59, -39.62 APE12-dist-na 9.191 APE11-dist-na 11.609 APE10-dist-na 7.365 APE9-dist-in 4.907 None None None XRAY 1.855 0.189 0.219 A 296 290 0 0 0 0 [[587, 856]] 1.0 7aaz Homo sapiens TYR_MERTK_HUMAN TYR 1.1e-92 315.9 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 9BHIA Q12866 578 864 999.0 A1APF:60901 Type1.5_Front Inactive DFGin 6.992 12.805 BLAminus -138.66, -158.87 44.96, 74.5 -90.39, 18.73 305.52, 137.7 -55.48, -30.3 out-out out 13.615 Saltbr-out 13.031 HRD-in -81.75, -51.8 68.35, 6.62 out-in-out SNCoio in-out ActLoopNT-in 2.82 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.15, 11.33 APE9-dihe-in -72.53, 150.77 APE8-dihe-in -64.75, 117.67 APE8-rot-na 25.92 APE67-dihe-in -73.91, -0.64 -53.67, -34.29 APE12-dist-na 7.154 APE11-dist-na 12.056 APE10-dist-na 11.657 APE9-dist-in 6.71 None None None XRAY 2.07 0.211 0.23 A 323 278 9 0 0 2 [[587, 856]] 1.0 9bhi Homo sapiens TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 9BHJA Q12866 578 862 999.0 A1APG:60901 Type1.5_Front Inactive DFGin 7.068 13.244 BLAminus -146.72, -174.1 64.74, 69.57 -92.99, 18.47 306.82, 135.89 -58.57, -33.38 out-out out 13.147 Saltbr-out 13.083 HRD-in -74.38, -50.97 66.43, 4.8 out-in-out SNCoio in-out ActLoopNT-in 2.931 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -101.13, 12.6 APE9-dihe-in -72.99, 145.36 APE8-dihe-in -59.15, 119.95 APE8-rot-na 335.8 APE67-dihe-in -75.1, -1.94 -63.08, -26.94 APE12-dist-na 7.006 APE11-dist-na 11.862 APE10-dist-na 11.009 APE9-dist-in 6.692 None None None XRAY 2.294 0.22 0.252 A 323 279 6 0 0 0 [[587, 856]] 1.0 9bhj Homo sapiens TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 9BHKA Q12866 578 862 999.0 A1APH:60901 Type1.5_Front Inactive DFGin 7.438 13.112 BLAminus -146.17, -169.74 58.59, 57.61 -88.08, 14.92 314.86, 133.55 -56.57, -30.36 out-out out 13.408 Saltbr-out 13.148 HRD-in -71.96, -51.79 69.44, 2.44 out-in-out SNCoio in-out ActLoopNT-in 2.846 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.49, 5.66 APE9-dihe-in -63.51, 142.65 APE8-dihe-in -57.87, 119.03 APE8-rot-na 336.99 APE67-dihe-in -73.75, -3.45 -57.71, -31.48 APE12-dist-na 7.129 APE11-dist-na 11.95 APE10-dist-na 11.013 APE9-dist-in 6.435 None None None XRAY 2.106 0.208 0.229 A 323 273 12 0 0 0 [[587, 856]] 1.0 9bhk Homo sapiens TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7M5ZB Q12866 574 862 999.0 YR7:901 Type1 Inactive DFGin 5.838 12.524 BLAplus -159.53, -178.04 60.44, 58.46 -114.79, 14.1 33.64, 70.49 -51.9, 999.0 out-out out 13.751 Saltbr-out 12.154 HRD-in -66.18, -42.82 66.6, -11.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 46.45 APE8-rot-na 30.1 APE67-dihe-in -68.0, -31.03 -61.8, -27.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 3.06 0.265 0.297 B 313 264 25 0 0 19 [[587, 856]] 1.0 7m5z Homo sapiens TYR_MERTK_HUMAN TYR 2.7e-92 314.7 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AVYA Q12866 576 863 999.0 S4E:901 Type1 Inactive DFGin 6.559 12.583 BLBminus -144.49, -173.14 43.51, 58.22 -65.27, 146.14 319.45, 104.85 -88.47, 168.4 out-out out 13.819 Saltbr-out 14.185 HRD-in -63.1, -54.14 77.2, -11.16 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 110.12 APE8-rot-na 25.31 APE67-dihe-in -73.48, -0.84 -44.31, -39.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.23 0.249 A 296 270 18 0 0 17 [[587, 856]] 1.0 7avy Homo sapiens TYR_MERTK_HUMAN TYR 1.1e-92 315.9 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AW2A Q12866 571 862 999.0 S4W:60901 Type1.5_Front Inactive DFGin 6.721 12.964 BLBminus -150.9, -171.53 41.59, 54.7 -57.18, 136.95 317.76, 109.5 -43.48, 130.9 out-out out 12.917 Saltbr-out 13.1 HRD-in -73.03, -51.56 71.01, 1.22 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.98 APE8-rot-na 17.36 APE67-dihe-in -72.89, 2.66 -33.8, -45.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 2.1 0.208 0.238 A 298 267 25 0 0 18 [[587, 856]] 1.0 7aw2 Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7OLSA Q12866 571 862 999.0 VJZ:60901 Type1.5_Front Inactive DFGin 6.656 13.567 BLBminus -153.83, -175.53 51.86, 59.49 -72.66, 142.42 308.34, 110.17 -75.07, 999.0 out-out out 13.556 Saltbr-out 13.877 HRD-in -70.87, -52.35 83.16, -32.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.15 APE8-rot-na 35.66 APE67-dihe-in -76.51, -1.1 -58.07, -40.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.89 0.222 0.282 A 298 269 23 0 0 19 [[587, 856]] 1.0 7ols Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7OLVA Q12866 571 862 999.0 VK2:60901 Type1.5_Front Inactive DFGin 6.528 13.64 BLBminus -149.58, -174.75 55.04, 54.02 -65.24, 140.11 308.45, 116.95 -72.6, 999.0 out-out out 13.503 Saltbr-out 14.112 HRD-in -71.43, -46.21 70.23, 5.98 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 78.84 APE8-rot-na 31.04 APE67-dihe-in -72.99, -5.09 -55.61, -36.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 2.13 0.21 0.247 A 298 269 23 0 0 19 [[587, 856]] 1.0 7olv Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7OLXA Q12866 571 862 999.0 VK5:60901 Type1.5_Front Inactive DFGin 6.209 13.727 BLBminus -149.38, -179.13 56.05, 51.35 -58.87, 139.21 312.09, 118.2 -79.48, 999.0 out-out out 13.764 Saltbr-out 12.352 HRD-in -72.38, -52.17 78.72, -5.83 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 42.77 APE8-rot-na 35.47 APE67-dihe-in -74.39, -3.51 -55.36, -38.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.98 0.205 0.251 A 298 271 21 0 0 19 [[587, 856]] 1.0 7olx Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 2P0CA Q12866 575 861 999.0 ANP:1 ATPlike Inactive DFGin 5.924 13.136 BLBplus -137.27, 178.6 60.37, 23.32 -81.61, 167.49 49.71, 91.11 85.65, -47.4 out-none out 13.649 Saltbr-none 999.0 HRD-in -80.53, -55.62 75.56, -3.56 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.71 APE8-rot-na 32.28 APE67-dihe-in -80.87, -2.88 -33.63, -45.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.274 A 313 249 38 0 0 18 [[587, 856]] 1.0 2p0c Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 2P0CB Q12866 575 861 999.0 ANP:2 ATPlike Inactive DFGin 6.034 13.332 BLBplus -140.6, 176.88 63.43, 26.39 -92.68, 153.87 48.18, 81.79 87.34, -0.94 out-none out 13.973 Saltbr-none 999.0 HRD-in -83.37, -59.67 75.95, 2.32 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.74 APE8-rot-na 27.11 APE67-dihe-in -70.68, -3.16 -43.98, -45.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.274 B 313 248 39 0 0 18 [[587, 856]] 1.0 2p0c Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 3BRBA Q12866 575 861 999.0 ADP:901 ATPlike Inactive DFGin 6.074 13.609 BLBplus -149.4, 172.79 64.51, 33.37 -100.26, 164.7 46.71, 83.96 59.32, 174.03 out-out out 13.75 Saltbr-out 12.558 HRD-in -82.25, -54.47 71.68, 7.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -42.31 APE8-dihe-in -85.78, 61.15 APE8-rot-na 26.09 APE67-dihe-in -74.59, -1.92 -45.39, -40.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.341 None None None XRAY 1.9 0.195 0.24 A 313 260 27 0 0 16 [[587, 856]] 1.0 3brb Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 3BRBB Q12866 575 863 999.0 ADP:901 ATPlike Inactive DFGin 5.874 13.373 BLBplus -148.45, 175.8 65.39, 30.29 -97.01, 161.01 52.76, 80.7 77.95, 168.41 out-out out 13.696 Saltbr-out 12.572 HRD-in -83.14, -55.33 72.79, 2.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.74 APE8-rot-na 30.57 APE67-dihe-in -72.04, -6.33 -47.66, -41.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.195 0.24 B 313 271 18 0 0 18 [[587, 856]] 1.0 3brb Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7CQEA Q12866 578 861 999.0 YDJ:906 Type1 Inactive DFGin 5.694 12.457 BLBplus -152.24, -170.16 49.35, 41.77 -91.57, 97.57 44.58, 57.14 74.0, 999.0 out-out out 14.268 Saltbr-out 13.063 HRD-in -70.01, -64.83 84.53, -1.87 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 63.73 APE8-rot-na 37.9 APE67-dihe-in -78.04, -1.46 -58.17, -32.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.69 0.203 0.259 A 294 253 31 0 0 19 [[587, 856]] 1.0 7cqe Homo sapiens TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7CQEC Q12866 578 861 999.0 YDJ:902 Type1 Inactive DFGin 6.41 13.001 BLBplus -154.28, -172.73 48.8, 38.59 -97.86, 95.79 39.92, 71.43 71.62, 999.0 out-out out 14.187 Saltbr-out 17.294 HRD-in -71.61, -64.11 82.96, 6.41 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.09 APE8-rot-na 37.08 APE67-dihe-in -77.01, -1.74 -56.95, -30.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.69 0.203 0.259 C 294 239 45 0 0 19 [[587, 856]] 1.0 7cqe Homo sapiens TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7DXLA Q12866 575 863 999.0 E56:901 Type1 Inactive DFGin 5.693 12.912 BLBplus -151.73, -179.85 59.55, 33.96 -96.78, 141.17 48.03, 89.29 122.99, -141.2 out-out out 14.406 Saltbr-out 11.326 HRD-in -82.78, -46.78 71.1, -14.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.94 APE8-dihe-out -84.62, 44.17 APE8-rot-na 34.04 APE67-dihe-in -61.75, -10.77 -55.95, -44.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.781 I650M None None XRAY 3.146 0.259 0.302 A 296 261 28 0 0 17 [[587, 856]] 1.0 7dxl Homo sapiens TYR_MERTK_HUMAN TYR 3.3e-92 314.4 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7DXLB Q12866 575 863 999.0 E56:901 Type1 Inactive DFGin 6.394 12.887 BLBplus -154.41, 174.83 65.7, 46.55 -105.06, 151.5 29.62, 85.97 72.51, 999.0 out-out out 13.873 Saltbr-out 12.938 HRD-in -88.29, -46.43 62.33, -8.53 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 12.68 APE8-rot-na 329.13 APE67-dihe-in -64.23, -9.78 -52.42, -47.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 I650M None None XRAY 3.146 0.259 0.302 B 296 256 33 0 0 19 [[587, 856]] 1.0 7dxl Homo sapiens TYR_MERTK_HUMAN TYR 3.3e-92 314.4 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 3BPRA Q12866 575 863 999.0 OLP:900 Type1 Inactive DFGin 5.686 12.304 BLBplus -137.26, -178.9 61.47, 12.73 -59.75, 137.03 20.33, 65.08 61.12, -116.43 out-out out 12.689 Saltbr-out 10.364 HRD-in -72.21, -60.59 74.99, 6.41 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 8.66 APE8-rot-na 26.27 APE67-dihe-in -74.48, 0.97 -50.81, -38.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.275 0.301 A 313 261 28 0 0 17 [[587, 856]] 1.0 3bpr Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 3BPRB Q12866 576 863 999.0 OLP:900 Type1 Inactive DFGin 5.696 12.309 BLBplus -135.14, -179.32 61.21, 14.94 -59.61, 138.18 20.13, 67.44 59.61, -114.67 out-out out 12.681 Saltbr-out 10.349 HRD-in -67.36, -58.88 72.16, 7.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 9.65 APE8-rot-na 23.75 APE67-dihe-in -74.27, 0.34 -51.9, -37.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.275 0.301 B 313 256 32 0 0 17 [[587, 856]] 1.0 3bpr Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 3BPRC Q12866 575 863 999.0 OLP:900 Type1 Inactive DFGin 5.653 12.314 BLBplus -137.44, -178.75 62.53, 10.12 -55.95, 136.39 21.78, 66.13 60.87, -116.77 out-out out 12.661 Saltbr-out 10.357 HRD-in -72.44, -61.45 74.91, 7.03 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 10.43 APE8-rot-na 24.85 APE67-dihe-in -75.54, 1.55 -53.21, -36.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.275 0.301 C 313 259 30 0 0 17 [[587, 856]] 1.0 3bpr Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 3BPRD Q12866 575 863 999.0 OLP:900 Type1 Inactive DFGin 5.704 12.316 BLBplus -139.18, -179.69 62.54, 13.28 -60.89, 135.81 20.55, 64.95 61.8, -113.74 out-out out 12.676 Saltbr-out 10.399 HRD-in -70.76, -61.42 73.63, 7.99 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 10.06 APE8-rot-na 25.2 APE67-dihe-in -76.88, 1.13 -52.53, -35.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.275 0.301 D 313 259 30 0 0 17 [[587, 856]] 1.0 3bpr Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 4M3QB Q12866 577 861 999.0 24K:904 Type1 Inactive DFGin 7.016 12.844 BLBplus -155.47, 177.8 59.97, 60.05 -123.11, 100.7 28.76, 84.8 73.7, 999.0 out-out out 13.113 Saltbr-out 8.269 HRD-in -77.58, -49.58 67.43, 9.99 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -8.23 APE8-rot-na 30.54 APE67-dihe-in -76.7, 7.19 -63.08, -36.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.718 0.248 0.296 B 313 236 49 0 0 19 [[587, 856]] 1.0 4m3q Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 4MHAA Q12866 580 863 999.0 4MH:904 Type1 Inactive DFGin 6.066 12.879 BLBplus -165.26, -177.42 65.13, 22.57 -85.11, 109.86 39.34, 89.59 -64.37, 999.0 out-out out 13.26 Saltbr-out 11.617 HRD-in -90.76, -48.14 63.93, 14.2 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 53.04 APE8-rot-na 30.98 APE67-dihe-in -69.86, -11.05 -63.45, -33.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.59 0.246 0.294 A 313 256 28 0 0 19 [[587, 856]] 1.0 4mha Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 5K0KA Q12866 577 863 999.0 6Q1:904 Type1 Inactive DFGin 6.043 13.083 BLBplus -151.37, 176.9 70.65, 6.45 -74.59, 148.34 49.33, 80.56 71.75, 161.84 out-out out 13.206 Saltbr-out 9.664 HRD-in -93.56, -51.52 71.26, 5.04 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 31.89 APE8-rot-na 27.0 APE67-dihe-in -74.95, 2.1 -52.33, -38.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.545 0.203 0.254 A 313 260 27 0 0 18 [[587, 856]] 1.0 5k0k Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 5K0XA Q12866 576 863 999.0 K0X:904 Type1 Inactive DFGin 6.004 13.123 BLBplus -141.68, 176.73 63.1, 26.77 -84.66, 126.17 47.94, 79.86 81.45, 999.0 out-out out 13.512 Saltbr-out 10.996 HRD-in -92.4, -57.41 77.73, 0.87 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -7.87 APE8-rot-na 21.82 APE67-dihe-in -69.98, -2.36 -41.05, -51.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.231 0.189 0.239 A 313 258 30 0 0 19 [[587, 856]] 1.0 5k0x Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 6MEPA Q12866 576 863 999.0 9VS:904 Type1.5_Back Inactive DFGin 6.881 13.685 BLBplus -143.01, -178.51 63.28, 31.36 -107.1, 128.61 51.55, 95.48 90.53, 175.14 out-out out 13.538 Saltbr-out 11.985 HRD-out -104.28, 87.47 -74.97, 17.26 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 63.86 APE8-rot-na 29.86 APE67-dihe-in -73.9, 3.63 -75.19, -36.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.893 0.21 0.268 A 313 250 38 0 0 17 [[587, 856]] 1.0 6mep Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AVXA Q12866 577 862 999.0 S4K:901 Type1.5_Front Inactive DFGin 6.212 14.187 BLBplus -139.94, 176.96 57.63, 33.7 -91.93, 149.58 50.89, 81.01 -76.42, 165.87 out-out out 12.696 Saltbr-out 9.191 HRD-in -70.33, -65.18 70.62, 12.45 out-out-out SNCooo out-out ActLoopNT-out 5.197 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -81.78, -23.56 APE9-dihe-in -75.41, 164.94 APE8-dihe-in -70.62, 164.17 APE8-rot-na 350.35 APE67-dihe-in -69.09, -9.08 -44.67, -43.43 APE12-dist-na 13.398 APE11-dist-na 14.161 APE10-dist-na 11.783 APE9-dist-in 4.623 None None None XRAY 2.44 0.216 0.259 A 313 276 10 0 0 5 [[587, 856]] 1.0 7avx Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 5TD2B Q12866 577 861 999.0 No_ligand No_ligand Inactive DFGin 6.793 13.116 None -144.11, 174.62 61.92, 63.15 -77.51, 999.0 303.45, 94.64 999.0, 999.0 out-out out 13.351 Saltbr-out 12.416 HRD-in -68.4, -50.94 72.94, 5.34 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 75.34 APE8-rot-na 32.97 APE67-dihe-in -69.61, -9.75 -67.34, -19.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.68 0.251 0.3 B 285 242 43 0 0 20 [[587, 856]] 1.0 5td2 Homo sapiens TYR_MERTK_HUMAN TYR 2.9e-92 314.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 4MH7B Q12866 577 862 999.0 No_ligand No_ligand Inactive DFGin 6.237 12.808 None -148.47, -179.73 64.64, 46.7 -122.89, 999.0 48.11, 70.87 999.0, 999.0 out-out out 12.896 Saltbr-out 12.926 HRD-in -78.94, -52.07 71.09, 5.48 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 23.45 APE8-rot-na 30.55 APE67-dihe-in -77.17, 1.49 -58.85, -30.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.51 0.228 0.279 B 313 255 31 0 0 20 [[587, 856]] 1.0 4mh7 Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 5TC0B Q12866 578 861 999.0 No_ligand No_ligand Inactive DFGin 5.977 12.879 None -140.01, 177.82 66.06, 34.51 -92.54, 999.0 25.62, 68.77 999.0, 999.0 out-out out 12.95 Saltbr-out 9.125 HRD-in -84.36, -52.52 74.32, 6.07 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -24.67 APE8-rot-na 31.87 APE67-dihe-in -69.09, -5.19 -56.41, -41.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.24 0.229 0.262 B 314 250 34 0 0 20 [[587, 856]] 1.0 5tc0 Homo sapiens TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AB0A Q12866 571 862 999.0 No_ligand No_ligand Inactive DFGin 6.624 14.014 None -143.7, 175.11 61.44, 47.67 -68.22, 999.0 316.54, 102.57 999.0, 999.0 out-out out 13.264 Saltbr-out 14.346 HRD-in -75.07, -54.59 74.43, 4.28 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.53 APE8-rot-na 33.09 APE67-dihe-in -75.24, -3.15 -51.47, -40.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.74 0.202 0.246 A 298 267 25 0 0 20 [[587, 856]] 1.0 7ab0 Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 5TD2A Q12866 577 861 999.0 7AE:1000 Type1 Inactive DFGin 6.134 13.651 None -143.3, 174.43 65.95, 82.51 -104.11, 999.0 312.2, 105.07 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.96, -51.07 72.28, 6.41 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 97.89 APE8-rot-na 25.82 APE67-dihe-in -75.54, -1.44 -65.62, -42.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.68 0.251 0.3 A 285 240 45 0 0 20 [[587, 856]] 1.0 5td2 Homo sapiens TYR_MERTK_HUMAN TYR 2.9e-92 314.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7OAMB Q12866 576 862 999.0 V6H:60901 Type1 Inactive DFGin 7.007 13.457 None -146.0, 178.63 58.31, 50.5 -120.77, 999.0 46.98, 69.39 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.67, -62.84 85.61, -10.13 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 97.98 APE8-dihe-in -79.78, 85.21 APE8-rot-na 33.46 APE67-dihe-in -75.72, -1.35 -61.95, -25.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.518 None None None XRAY 2.65 0.224 0.257 B 296 250 37 0 0 19 [[587, 856]] 1.0 7oam Homo sapiens TYR_MERTK_HUMAN TYR 1.1e-92 315.9 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 3TCPA Q12866 577 863 999.0 CKJ:1 Type1 Inactive DFGin 6.203 12.893 None -136.14, -178.38 58.94, 40.23 -104.0, 999.0 45.8, 90.86 999.0, 999.0 out-out out 13.07 Saltbr-out 10.087 HRD-in -71.3, -54.4 78.76, -16.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 71.51 APE8-rot-na 24.96 APE67-dihe-in -68.45, -1.97 -46.97, -39.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.69 0.228 0.298 A 313 256 31 0 0 20 [[587, 856]] 1.0 3tcp Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 3TCPB Q12866 576 861 999.0 CKJ:2 Type1 Inactive DFGin 6.542 12.725 None -151.12, -175.9 57.3, 28.48 -93.29, 999.0 44.8, 72.64 999.0, 999.0 out-none out 12.011 Saltbr-none 999.0 HRD-in -62.48, -45.95 68.1, -10.21 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -34.04 APE8-dihe-in -94.24, 71.38 APE8-rot-na 31.8 APE67-dihe-in -76.89, -2.28 -48.4, -36.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.261 None None None XRAY 2.69 0.228 0.298 B 313 250 36 0 0 19 [[587, 856]] 1.0 3tcp Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 4M3QA Q12866 578 861 999.0 24K:906 Type1 Inactive DFGin 5.962 13.272 None -156.18, 179.21 59.94, 63.59 -121.26, 999.0 26.4, 60.96 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -76.83, -49.1 68.2, 10.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -8.28 APE8-rot-na 30.83 APE67-dihe-in -76.46, 5.82 -62.87, -37.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.718 0.248 0.296 A 313 243 41 0 0 20 [[587, 856]] 1.0 4m3q Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 4MH7A Q12866 577 861 999.0 MH7:906 Type1 Inactive DFGin 6.673 13.733 None -149.88, -177.32 66.64, 46.5 -124.55, 999.0 44.22, 68.98 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -78.51, -51.41 72.09, 3.88 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 23.58 APE8-rot-na 30.75 APE67-dihe-in -78.5, 1.01 -58.56, -31.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.51 0.228 0.279 A 313 248 37 0 0 20 [[587, 856]] 1.0 4mh7 Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 4MHAB Q12866 577 862 999.0 4MH:905 Type1 Inactive DFGin 5.588 13.166 None -164.91, -178.11 62.75, 50.05 -120.6, 999.0 47.74, 75.91 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -87.47, -43.02 65.67, 7.44 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 102.4 APE8-rot-na 29.27 APE67-dihe-in -76.83, 2.21 -113.8, -35.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.59 0.246 0.294 B 313 246 40 0 0 20 [[587, 856]] 1.0 4mha Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 5K0KB Q12866 577 862 999.0 6Q1:904 Type1 Inactive DFGin 6.189 13.389 None -144.02, -179.34 56.66, 60.57 -135.11, 999.0 52.83, 74.37 999.0, 999.0 out-out out 12.83 Saltbr-out 9.006 HRD-in -81.18, -49.68 74.51, -7.68 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.62 APE8-rot-na 27.52 APE67-dihe-in -73.94, -3.99 -57.79, -40.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.545 0.203 0.254 B 313 248 38 0 0 20 [[587, 856]] 1.0 5k0k Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 5TC0A Q12866 578 861 999.0 79Y:1100 Type1 Inactive DFGin 5.868 13.093 None -140.95, 176.68 72.06, 53.5 -127.68, 999.0 35.95, 63.07 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -85.04, -52.33 70.75, 9.58 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 51.99 APE8-dihe-in -70.22, 110.63 APE8-rot-na 29.77 APE67-dihe-in -71.61, -2.78 -54.4, -35.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.184 None None None XRAY 2.24 0.229 0.262 A 314 238 46 0 0 19 [[587, 856]] 1.0 5tc0 Homo sapiens TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 5U6CA Q12866 572 864 999.0 7YS:9001 Type1 Inactive DFGin 6.514 13.097 None -140.41, -178.19 73.14, -58.25 59.05, 38.04 321.05, 119.16 47.3, 38.19 out-out out 12.238 Saltbr-out 10.41 HRD-in -76.31, -59.9 77.64, -5.13 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -19.89 APE8-rot-na 24.77 APE67-dihe-in -66.57, -0.63 -47.81, -46.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.214 0.257 A 315 272 21 0 0 17 [[587, 856]] 1.0 5u6c Homo sapiens TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 5U6CB Q12866 575 862 999.0 7YS:9001 Type1 Inactive DFGin 5.756 13.39 None -146.75, -178.14 49.0, 37.86 -93.39, 999.0 43.6, 77.83 999.0, 999.0 out-out out 13.856 Saltbr-out 11.107 HRD-in -77.29, -57.91 76.71, -6.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 163.75 APE8-dihe-in -83.33, 57.19 APE8-rot-na 31.94 APE67-dihe-in -71.79, -2.99 -38.38, -48.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.061 None None None XRAY 2.1 0.214 0.257 B 315 257 31 0 0 19 [[587, 856]] 1.0 5u6c Homo sapiens TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AB1A Q12866 571 862 999.0 C6F:60901 Type1 Inactive DFGin 5.872 13.527 None -150.27, 178.21 48.78, 48.66 -107.87, 999.0 41.9, 85.18 999.0, 999.0 out-out out 12.844 Saltbr-out 9.566 HRD-in -84.92, -52.07 85.67, -41.55 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.29 APE8-rot-na 36.31 APE67-dihe-in -65.53, -14.5 -57.08, -42.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.93 0.237 0.298 A 298 267 25 0 0 20 [[587, 856]] 1.0 7ab1 Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AB2A Q12866 571 862 999.0 R6N:60901 Type1 Inactive DFGin 6.328 13.588 None -148.22, 175.53 55.93, 53.34 -74.83, 999.0 329.09, 104.95 999.0, 999.0 out-out out 13.203 Saltbr-out 14.57 HRD-in -79.16, -56.47 81.41, -4.68 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 64.62 APE8-rot-na 36.54 APE67-dihe-in -78.04, -6.9 -58.38, -34.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.78 0.196 0.25 A 298 267 25 0 0 20 [[587, 856]] 1.0 7ab2 Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AVZA Q12866 571 862 999.0 S4N:60901 Type1 Inactive DFGin 6.269 13.59 None -145.45, 176.2 52.56, 50.67 -72.23, 999.0 339.86, 87.13 999.0, 999.0 out-out out 12.984 Saltbr-out 9.923 HRD-in -69.09, -58.13 78.41, -16.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -7.96 APE8-rot-na 31.06 APE67-dihe-in -76.22, 2.71 -47.31, -44.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 2.04 0.207 0.229 A 298 265 27 0 0 20 [[587, 856]] 1.0 7avz Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AW0A Q12866 571 862 999.0 S4Q:60901 Type1 Inactive DFGin 6.074 13.887 None -146.33, 175.15 58.08, 44.92 -106.5, 999.0 37.04, 79.3 999.0, 999.0 out-out out 13.159 Saltbr-out 9.893 HRD-in -73.83, -55.86 76.62, -13.66 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 69.76 APE8-rot-na 19.28 APE67-dihe-in -68.82, -6.08 -45.38, -39.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.893 0.204 0.233 A 298 266 26 0 0 20 [[587, 856]] 1.0 7aw0 Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AW3A Q12866 571 862 999.0 S4Z:60901 Type1 Inactive DFGin 6.136 13.492 None -141.96, 175.75 54.61, 48.83 -104.75, 999.0 29.07, 73.23 999.0, 999.0 out-out out 13.253 Saltbr-out 10.167 HRD-in -76.56, -55.94 78.32, -15.64 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.13 APE8-rot-na 30.36 APE67-dihe-in -72.86, -3.93 -46.59, -40.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.99 0.217 0.245 A 298 266 26 0 0 20 [[587, 856]] 1.0 7aw3 Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7M5ZA Q12866 577 862 999.0 YR7:901 Type1 Inactive DFGin 5.681 14.174 None -159.0, -169.59 47.7, 65.14 -69.86, 999.0 300.1, 112.68 999.0, 999.0 in-out in 9.256 Saltbr-out 6.024 HRD-in -77.96, -43.12 69.37, -0.08 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 13.83 APE8-rot-na 32.06 APE67-dihe-in -66.59, -6.13 -57.74, -32.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 3.06 0.265 0.297 A 313 263 23 0 0 20 [[587, 856]] 1.0 7m5z Homo sapiens TYR_MERTK_HUMAN TYR 2.7e-92 314.7 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 6MEPB Q12866 578 862 999.0 9VS:904 Type1.5_Back Inactive DFGin 6.137 13.751 None -149.56, -177.34 59.65, 39.31 -110.56, 999.0 52.79, 83.98 999.0, 999.0 out-out out 12.835 Saltbr-out 11.807 HRD-out -99.49, 96.49 -80.13, -3.87 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 68.16 APE8-rot-na 30.37 APE67-dihe-in -67.86, -3.3 -78.71, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.893 0.21 0.268 B 313 236 49 0 0 20 [[587, 856]] 1.0 6mep Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 9KS9B Q12866 577 863 999.0 A1L6L:901 Type1 Inactive DFGout 16.68 9.571 BBAminus -150.93, -175.1 -149.15, 104.97 -55.25, -29.1 282.42, 72.66 68.42, 999.0 out-none out 12.294 Saltbr-none 999.0 HRD-in -61.19, -61.05 76.89, -1.4 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 45.22 APE8-rot-na 27.27 APE67-dihe-in -61.05, -25.0 -62.95, -42.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.212 0.26 B 294 259 28 0 0 19 [[587, 856]] 1.0 9ks9 Homo sapiens TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7XHYA Q12866 571 862 999.0 E0X:60901 Type1 Inactive DFGout 16.043 9.147 BBAminus -145.7, -173.77 -157.94, 107.94 -59.29, -23.23 277.42, 83.07 47.74, 57.36 out-out out 13.309 Saltbr-out 10.486 HRD-in -73.65, -57.9 79.12, -8.03 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 28.15 APE8-rot-na 34.93 APE67-dihe-in -74.84, -2.33 -55.6, -34.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 2.16 0.212 0.252 A 298 267 25 0 0 18 [[587, 856]] 1.0 7xhy Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AAYA Q12866 571 862 999.0 L1X:60901 Type2 Inactive DFGout 15.272 11.553 BBAminus -158.07, -174.81 -144.2, 119.75 -72.18, -30.61 282.04, 79.68 81.94, 999.0 in-in in 8.727 Saltbr-in 2.808 HRD-in -70.71, -62.02 81.51, -21.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -56.79 APE8-dihe-out -51.76, -19.75 APE8-rot-na 333.06 APE67-dihe-in -71.89, -3.89 -51.82, -34.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.661 None None None XRAY 1.87 0.197 0.224 A 294 270 18 0 0 18 [[587, 856]] 1.0 7aay Homo sapiens TYR_MERTK_HUMAN TYR 5.3e-93 317.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 9KRYB Q12866 580 863 999.0 A1L6J:901 Type2 Inactive DFGout 16.962 9.427 BBAminus -147.28, -173.49 -155.52, 108.98 -61.25, -61.35 276.25, 91.0 70.46, 26.54 out-none out 13.103 Saltbr-none 999.0 HRD-in -73.14, -53.57 69.92, -2.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.5 APE8-rot-na 26.98 APE67-dihe-in -76.71, -9.16 -55.23, -33.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.242 0.284 B 294 252 32 0 0 18 [[587, 856]] 1.0 9kry Homo sapiens TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AW4A Q12866 576 862 999.0 S5E:901 Type3 Inactive DFGout 14.166 6.988 BBAminus -151.73, 174.5 -134.58, 93.64 -99.75, 11.14 282.83, 106.8 -60.06, 134.62 out-out out 12.678 Saltbr-out 6.924 HRD-in -71.68, -56.26 76.66, -5.4 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 37.4 APE8-rot-na 27.32 APE67-dihe-in -72.74, -3.62 -49.0, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.98 0.215 0.246 A 313 264 23 0 0 17 [[587, 856]] 1.0 7aw4 Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AW4B Q12866 574 862 999.0 S5E:901 Type3 Inactive DFGout 14.17 7.002 BBAminus -152.39, 174.35 -134.62, 92.94 -100.47, 8.02 282.22, 107.21 -60.15, 130.28 out-out out 12.756 Saltbr-out 7.104 HRD-in -72.36, -56.01 76.07, -4.93 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 37.48 APE8-rot-na 27.51 APE67-dihe-in -72.81, -3.1 -48.72, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.98 0.215 0.246 B 313 257 32 0 0 18 [[587, 856]] 1.0 7aw4 Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AVXB Q12866 577 862 999.0 S4K:901 Type1 Inactive DFGout 16.233 9.367 None -141.54, -179.69 -114.73, -166.9 -158.87, 999.0 260.93, 100.77 999.0, 999.0 out-out out 12.963 Saltbr-out 9.387 HRD-in -69.0, -65.55 71.08, 10.89 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.94 APE8-rot-na 24.19 APE67-dihe-in -68.67, -9.11 -43.26, -44.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.44 0.216 0.259 B 313 263 23 0 0 20 [[587, 856]] 1.0 7avx Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 9KRZA Q12866 577 864 999.0 A1L6K:901 Type1.5_Front Inactive DFGout 16.995 9.166 None -144.96, 178.8 -147.12, 97.05 -55.74, 999.0 272.88, 54.11 999.0, 999.0 out-none out 12.645 Saltbr-none 999.0 HRD-in -83.04, -57.33 76.85, -1.67 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 22.11 APE8-rot-na 9.43 APE67-dihe-in -73.23, -7.29 -55.21, -31.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.224 0.267 A 294 263 25 0 0 20 [[587, 856]] 1.0 9krz Homo sapiens TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 9KRZB Q12866 575 863 999.0 A1L6K:901 Type1.5_Front Inactive DFGout 17.116 9.26 None -136.76, -173.26 -147.11, 97.01 -63.71, 999.0 262.09, 109.75 999.0, 999.0 out-none out 12.404 Saltbr-none 999.0 HRD-in -59.48, -61.4 74.72, -1.69 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.37 APE8-rot-na 32.13 APE67-dihe-in -79.29, -5.37 -59.11, -19.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.224 0.267 B 294 260 29 0 0 20 [[587, 856]] 1.0 9krz Homo sapiens TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 9KRYA Q12866 580 863 999.0 A1L6J:901 Type2 Inactive DFGout 16.021 9.312 None -145.17, -171.5 -155.53, 115.18 -76.36, 999.0 280.47, 88.85 999.0, 999.0 out-out out 10.614 Saltbr-out 4.668 HRD-in -79.08, -57.6 74.04, -4.61 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 14.81 APE8-rot-na 349.6 APE67-dihe-in -82.44, -0.93 -60.68, -30.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.242 0.284 A 294 249 35 0 0 20 [[587, 856]] 1.0 9kry Homo sapiens TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 9KS9A Q12866 576 862 999.0 A1L6L:1001 Type2 Inactive DFGout 15.524 9.27 None -150.99, -177.04 -153.01, 113.06 -69.38, 999.0 286.5, 79.65 999.0, 999.0 out-out out 10.161 Saltbr-out 4.673 HRD-in -73.1, -59.19 76.81, -1.34 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 25.41 APE8-rot-na 29.26 APE67-dihe-in -77.0, -9.07 -59.08, -33.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.212 0.26 A 294 262 25 0 0 20 [[587, 856]] 1.0 9ks9 Homo sapiens TYR_MERTK_HUMAN TYR 1.1e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AAXA Q12866 571 862 999.0 R6H:60901 Type2 Inactive DFGout 15.733 8.907 None -138.81, -167.54 -165.53, 104.61 -69.55, 999.0 281.2, 84.02 999.0, 999.0 out-out out 12.981 Saltbr-out 13.872 HRD-in -71.43, -58.84 84.16, -7.62 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 9.57 APE8-rot-na 34.0 APE67-dihe-in -78.18, -0.39 -55.56, -36.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.762 0.202 0.253 A 298 267 25 0 0 20 [[587, 856]] 1.0 7aax Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7AW1A Q12866 571 862 999.0 S4T:60901 Type2 Inactive DFGout 16.346 9.562 None -147.65, -171.05 -165.02, 92.03 -50.93, 999.0 282.63, 88.85 999.0, 999.0 out-out out 13.311 Saltbr-out 10.463 HRD-in -79.03, -54.45 77.4, -8.22 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 60.11 APE8-rot-na 28.27 APE67-dihe-in -65.96, -9.73 -45.0, -44.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.98 0.203 0.225 A 298 265 27 0 0 20 [[587, 856]] 1.0 7aw1 Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 7OAMA Q12866 575 863 999.0 No_ligand No_ligand Inactive None 999.0 999.0 None -144.87, 174.24 51.78, 47.89 113.25, 999.0 999.0, 999.0 999.0, 999.0 out-none out 13.006 Saltbr-none 999.0 HRD-in -73.54, -63.06 83.28, -5.74 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.53 APE8-dihe-in -87.85, 50.31 APE8-rot-na 32.97 APE67-dihe-in -74.96, -1.44 -63.88, -24.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.315 None None None XRAY 2.65 0.224 0.257 A 296 260 29 0 0 19 [[587, 856]] 1.0 7oam Homo sapiens TYR_MERTK_HUMAN TYR 1.1e-92 315.9 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
MERTK_HUMAN 5K0XB Q12866 575 863 999.0 K0X:903 Type1 Inactive None 999.0 999.0 None -144.28, -179.95 63.63, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 13.28 Saltbr-out 11.559 HRD-in -82.77, -56.55 75.35, 0.54 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 69.74 APE8-rot-na 36.04 APE67-dihe-in -72.66, -3.44 -60.52, -36.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.231 0.189 0.239 B 313 254 35 0 0 21 [[587, 856]] 1.0 5k0x Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer

TYR_MERTK (Tyrosine-protein kinase Mer)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name