CMGC_MAPK12 (Mitogen-activated protein kinase 12)

Total number of chains: 10
Active chains: 4
Family: CMGC
Uniprot: MK12_HUMAN
Kinase Domain Residues: 27 - 311
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 50.0% AF-P53778-K1A
DFGin ABAminus 3 30.0% 7CGAB
DFGin BLBplus 2 20.0% 6UNAA

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
1CM8A 8 353 367.0 ANP:60400 ATPlike Active DFGin 6.965 14.774 BLAminus -109.08, -177.81 49.88, 82.62 -94.66, 21.96 279.65, 74.31 -61.38, -21.21 in-in in 9.0 Saltbr-in 2.777 HRD-in -80.35, -48.18 64.34, 20.91 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 159.85 APE9-dihe-na 73.62, 141.22 APE8-dihe-in -70.32, 134.6 APE8-rot-in 295.09 APE67-dihe-in -62.17, -12.08 -34.13, -61.33 APE12-dist-in 11.604 APE11-dist-in 10.956 APE10-dist-in 6.991 APE9-dist-in 3.072 None TPO183,PTR185 TPO183,PTR185 XRAY 2.4 0.232 0.283 A 367 329 6 0 0 0 [[27, 311]] 1.0 1cm8 CMGC_MAPK12_HUMAN CMGC 5.6e-85 291.2 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
1CM8B 8 353 367.0 ANP:61400 ATPlike Active DFGin 6.965 14.794 BLAminus -106.93, -177.79 50.51, 81.99 -94.3, 22.09 279.91, 74.94 -61.07, -21.75 in-in in 9.031 Saltbr-in 2.759 HRD-in -80.7, -47.04 63.03, 19.82 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 160.62 APE9-dihe-na 73.12, 141.25 APE8-dihe-in -70.38, 133.34 APE8-rot-in 295.67 APE67-dihe-in -62.05, -11.85 -33.55, -61.0 APE12-dist-in 11.613 APE11-dist-in 10.95 APE10-dist-in 6.996 APE9-dist-in 3.048 None TPO183,PTR185 TPO183,PTR185 XRAY 2.4 0.232 0.283 B 367 329 6 0 0 0 [[27, 311]] 1.0 1cm8 CMGC_MAPK12_HUMAN CMGC 5.6e-85 291.2 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
AF-P53778-K1A 19 319 367.0 No_ligand No_ligand Active DFGin 6.942 14.58 BLAminus -114.74, 171.49 59.55, 70.2 -81.36, 15.32 288.02, 85.0 -61.25, -29.33 in-in in 9.071 Saltbr-in 2.653 HRD-in -75.03, -49.4 63.95, 16.94 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.53, 169.25 APE9-dihe-na 64.71, 138.58 APE8-dihe-in -57.41, 128.64 APE8-rot-in 298.8 APE67-dihe-in -69.45, -18.41 -45.26, -45.85 APE12-dist-in 11.292 APE11-dist-in 11.337 APE10-dist-in 6.96 APE9-dist-in 3.155 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[27, 311]] 1.0 AF-P53778-K1 CMGC_MAPK12_HUMAN CMGC 2.7e-85 292.1 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
AF-P53778-K3A 19 319 367.0 No_ligand No_ligand Active DFGin 6.654 14.413 BLAminus -117.05, 172.87 62.36, 62.32 -74.09, 13.82 287.94, 79.39 -62.76, -22.02 in-in in 9.405 Saltbr-in 2.718 HRD-in -73.87, -45.92 63.52, 15.65 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.66, 170.51 APE9-dihe-na 63.91, 132.83 APE8-dihe-in -56.22, 129.24 APE8-rot-in 295.98 APE67-dihe-in -70.87, -16.95 -43.53, -47.75 APE12-dist-in 10.943 APE11-dist-in 10.856 APE10-dist-in 6.556 APE9-dist-in 3.151 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[27, 311]] 1.0 AF-P53778-K3 CMGC_MAPK12_HUMAN CMGC 2.7e-85 292.1 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
7CGAB 9 353 367.0 No_ligand No_ligand Inactive DFGin 6.272 14.969 ABAminus -110.86, -62.49 -102.64, 106.93 -94.38, 23.15 281.27, 88.51 -76.7, -25.42 in-in in 9.312 Saltbr-in 2.695 HRD-out -79.77, 114.92 -94.73, 10.19 in-in-out SNCiio in-out ActLoopNT-in 2.832 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -57.15, 115.35 APE9-dihe-na -85.53, -51.12 APE8-dihe-in -51.2, 127.61 APE8-rot-in 312.11 APE67-dihe-in -63.98, -37.1 -91.4, -47.81 APE12-dist-out 6.55 APE11-dist-in 9.418 APE10-dist-in 7.485 APE9-dist-out 8.271 None None None XRAY 3.15 0.163 0.218 B 348 345 0 0 0 0 [[27, 311]] 1.0 7cga CMGC_MAPK12_HUMAN CMGC 4.7e-85 291.4 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
7CGAC 9 353 367.0 No_ligand No_ligand Inactive DFGin 6.776 15.068 ABAminus -115.28, -58.81 -110.37, 107.81 -95.19, 9.49 276.0, 86.92 -68.22, -14.79 in-in in 9.083 Saltbr-in 3.218 HRD-out -52.52, 150.85 -125.06, 11.69 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -70.64, 118.03 APE9-dihe-na -84.55, -56.95 APE8-dihe-in -38.51, 120.41 APE8-rot-in 307.31 APE67-dihe-in -68.67, -38.99 -90.47, -46.68 APE12-dist-out 6.852 APE11-dist-in 9.304 APE10-dist-in 7.744 APE9-dist-out 8.379 None None None XRAY 3.15 0.163 0.218 C 348 345 0 0 0 0 [[27, 311]] 1.0 7cga CMGC_MAPK12_HUMAN CMGC 4.7e-85 291.4 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
7CGAD 9 353 367.0 No_ligand No_ligand Inactive DFGin 6.685 14.652 ABAminus -119.58, -46.64 -112.32, 106.79 -92.17, 3.91 283.23, 103.54 -68.25, -11.35 in-in in 8.987 Saltbr-in 2.679 HRD-out -90.17, 97.99 -84.21, 7.22 in-in-out SNCiio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -63.92, 117.14 APE9-dihe-na -85.66, -57.65 APE8-dihe-in -38.77, 133.64 APE8-rot-in 316.55 APE67-dihe-in -82.55, -28.14 -108.44, -27.55 APE12-dist-out 6.946 APE11-dist-in 9.434 APE10-dist-in 7.761 APE9-dist-out 8.591 None None None XRAY 3.15 0.163 0.218 D 348 345 0 0 0 0 [[27, 311]] 1.0 7cga CMGC_MAPK12_HUMAN CMGC 4.7e-85 291.4 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
7CGAA 9 353 367.0 No_ligand No_ligand Inactive DFGin 6.511 14.803 BLAminus -102.95, 174.14 60.25, 88.75 -98.15, 16.52 279.5, 81.2 -76.27, -1.53 in-in in 8.695 Saltbr-in 3.1 HRD-in -69.44, -53.9 82.33, -6.84 in-in-out SNCiio in-out ActLoopNT-in 2.919 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -80.58, 119.04 APE9-dihe-na -87.45, -57.23 APE8-dihe-in -48.06, 132.7 APE8-rot-in 311.02 APE67-dihe-in -70.61, -33.55 -106.57, -39.76 APE12-dist-out 6.532 APE11-dist-in 9.295 APE10-dist-in 7.491 APE9-dist-out 8.169 None None None XRAY 3.15 0.163 0.218 A 348 345 0 0 0 0 [[27, 311]] 1.0 7cga CMGC_MAPK12_HUMAN CMGC 4.7e-85 291.4 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
6UNAA 10 351 367.0 No_ligand No_ligand Inactive DFGin 4.688 14.348 BLBplus -119.22, 158.65 56.88, 54.29 -106.73, 143.29 55.57, 87.52 77.47, -10.4 in-in in 9.304 Saltbr-in 2.938 HRD-in -70.3, -54.18 80.54, -18.41 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -43.48 APE8-dihe-out -98.96, -53.24 APE8-rot-out 36.51 APE67-dihe-in -67.95, -19.14 -119.83, 10.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.257 Q31R None None XRAY 2.554 0.198 0.245 A 361 329 11 0 0 11 [[27, 311]] 1.0 6una CMGC_MAPK12_HUMAN CMGC 3.7e-85 291.7 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
6UNAB 9 351 367.0 No_ligand No_ligand Inactive DFGin 4.551 13.878 BLBplus -121.26, 156.28 59.95, 55.75 -100.45, 141.03 54.7, 95.97 -138.82, -13.73 in-in in 8.974 Saltbr-in 2.656 HRD-in -69.85, -53.43 80.9, -19.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.32 APE8-dihe-in -102.04, 126.27 APE8-rot-out 36.5 APE67-dihe-in -64.94, -15.57 -104.48, -13.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.439 Q31R None None XRAY 2.554 0.198 0.245 B 361 331 12 0 0 12 [[27, 311]] 1.0 6una CMGC_MAPK12_HUMAN CMGC 3.7e-85 291.7 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12

CMGC_MAPK12 (Mitogen-activated protein kinase 12)

Total number of chains: 10
Active chains: 4
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 50.0% AF-P53778-K1A
DFGin ABAminus 3 30.0% 7CGAB
DFGin BLBplus 2 20.0% 6UNAA

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MK12_HUMAN 1CM8A P53778 8 353 367.0 ANP:60400 ATPlike Active DFGin 6.965 14.774 BLAminus -109.08, -177.81 49.88, 82.62 -94.66, 21.96 279.65, 74.31 -61.38, -21.21 in-in in 9.0 Saltbr-in 2.777 HRD-in -80.35, -48.18 64.34, 20.91 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 159.85 APE9-dihe-na 73.62, 141.22 APE8-dihe-in -70.32, 134.6 APE8-rot-in 295.09 APE67-dihe-in -62.17, -12.08 -34.13, -61.33 APE12-dist-in 11.604 APE11-dist-in 10.956 APE10-dist-in 6.991 APE9-dist-in 3.072 None TPO183,PTR185 TPO183,PTR185 XRAY 2.4 0.232 0.283 A 367 329 6 0 0 0 [[27, 311]] 1.0 1cm8 Homo sapiens CMGC_MAPK12_HUMAN CMGC 5.6e-85 291.2 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
MK12_HUMAN 1CM8B P53778 8 353 367.0 ANP:61400 ATPlike Active DFGin 6.965 14.794 BLAminus -106.93, -177.79 50.51, 81.99 -94.3, 22.09 279.91, 74.94 -61.07, -21.75 in-in in 9.031 Saltbr-in 2.759 HRD-in -80.7, -47.04 63.03, 19.82 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 160.62 APE9-dihe-na 73.12, 141.25 APE8-dihe-in -70.38, 133.34 APE8-rot-in 295.67 APE67-dihe-in -62.05, -11.85 -33.55, -61.0 APE12-dist-in 11.613 APE11-dist-in 10.95 APE10-dist-in 6.996 APE9-dist-in 3.048 None TPO183,PTR185 TPO183,PTR185 XRAY 2.4 0.232 0.283 B 367 329 6 0 0 0 [[27, 311]] 1.0 1cm8 Homo sapiens CMGC_MAPK12_HUMAN CMGC 5.6e-85 291.2 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
MK12_HUMAN AF-P53778-K1A P53778 19 319 367.0 No_ligand No_ligand Active DFGin 6.942 14.58 BLAminus -114.74, 171.49 59.55, 70.2 -81.36, 15.32 288.02, 85.0 -61.25, -29.33 in-in in 9.071 Saltbr-in 2.653 HRD-in -75.03, -49.4 63.95, 16.94 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.53, 169.25 APE9-dihe-na 64.71, 138.58 APE8-dihe-in -57.41, 128.64 APE8-rot-in 298.8 APE67-dihe-in -69.45, -18.41 -45.26, -45.85 APE12-dist-in 11.292 APE11-dist-in 11.337 APE10-dist-in 6.96 APE9-dist-in 3.155 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[27, 311]] 1.0 AF-P53778-K1 Homo sapiens CMGC_MAPK12_HUMAN CMGC 2.7e-85 292.1 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
MK12_HUMAN AF-P53778-K3A P53778 19 319 367.0 No_ligand No_ligand Active DFGin 6.654 14.413 BLAminus -117.05, 172.87 62.36, 62.32 -74.09, 13.82 287.94, 79.39 -62.76, -22.02 in-in in 9.405 Saltbr-in 2.718 HRD-in -73.87, -45.92 63.52, 15.65 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.66, 170.51 APE9-dihe-na 63.91, 132.83 APE8-dihe-in -56.22, 129.24 APE8-rot-in 295.98 APE67-dihe-in -70.87, -16.95 -43.53, -47.75 APE12-dist-in 10.943 APE11-dist-in 10.856 APE10-dist-in 6.556 APE9-dist-in 3.151 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[27, 311]] 1.0 AF-P53778-K3 Homo sapiens CMGC_MAPK12_HUMAN CMGC 2.7e-85 292.1 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
MK12_HUMAN 7CGAB P53778 9 353 367.0 No_ligand No_ligand Inactive DFGin 6.272 14.969 ABAminus -110.86, -62.49 -102.64, 106.93 -94.38, 23.15 281.27, 88.51 -76.7, -25.42 in-in in 9.312 Saltbr-in 2.695 HRD-out -79.77, 114.92 -94.73, 10.19 in-in-out SNCiio in-out ActLoopNT-in 2.832 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -57.15, 115.35 APE9-dihe-na -85.53, -51.12 APE8-dihe-in -51.2, 127.61 APE8-rot-in 312.11 APE67-dihe-in -63.98, -37.1 -91.4, -47.81 APE12-dist-out 6.55 APE11-dist-in 9.418 APE10-dist-in 7.485 APE9-dist-out 8.271 None None None XRAY 3.15 0.163 0.218 B 348 345 0 0 0 0 [[27, 311]] 1.0 7cga Homo sapiens CMGC_MAPK12_HUMAN CMGC 4.7e-85 291.4 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
MK12_HUMAN 7CGAC P53778 9 353 367.0 No_ligand No_ligand Inactive DFGin 6.776 15.068 ABAminus -115.28, -58.81 -110.37, 107.81 -95.19, 9.49 276.0, 86.92 -68.22, -14.79 in-in in 9.083 Saltbr-in 3.218 HRD-out -52.52, 150.85 -125.06, 11.69 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -70.64, 118.03 APE9-dihe-na -84.55, -56.95 APE8-dihe-in -38.51, 120.41 APE8-rot-in 307.31 APE67-dihe-in -68.67, -38.99 -90.47, -46.68 APE12-dist-out 6.852 APE11-dist-in 9.304 APE10-dist-in 7.744 APE9-dist-out 8.379 None None None XRAY 3.15 0.163 0.218 C 348 345 0 0 0 0 [[27, 311]] 1.0 7cga Homo sapiens CMGC_MAPK12_HUMAN CMGC 4.7e-85 291.4 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
MK12_HUMAN 7CGAD P53778 9 353 367.0 No_ligand No_ligand Inactive DFGin 6.685 14.652 ABAminus -119.58, -46.64 -112.32, 106.79 -92.17, 3.91 283.23, 103.54 -68.25, -11.35 in-in in 8.987 Saltbr-in 2.679 HRD-out -90.17, 97.99 -84.21, 7.22 in-in-out SNCiio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -63.92, 117.14 APE9-dihe-na -85.66, -57.65 APE8-dihe-in -38.77, 133.64 APE8-rot-in 316.55 APE67-dihe-in -82.55, -28.14 -108.44, -27.55 APE12-dist-out 6.946 APE11-dist-in 9.434 APE10-dist-in 7.761 APE9-dist-out 8.591 None None None XRAY 3.15 0.163 0.218 D 348 345 0 0 0 0 [[27, 311]] 1.0 7cga Homo sapiens CMGC_MAPK12_HUMAN CMGC 4.7e-85 291.4 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
MK12_HUMAN 7CGAA P53778 9 353 367.0 No_ligand No_ligand Inactive DFGin 6.511 14.803 BLAminus -102.95, 174.14 60.25, 88.75 -98.15, 16.52 279.5, 81.2 -76.27, -1.53 in-in in 8.695 Saltbr-in 3.1 HRD-in -69.44, -53.9 82.33, -6.84 in-in-out SNCiio in-out ActLoopNT-in 2.919 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -80.58, 119.04 APE9-dihe-na -87.45, -57.23 APE8-dihe-in -48.06, 132.7 APE8-rot-in 311.02 APE67-dihe-in -70.61, -33.55 -106.57, -39.76 APE12-dist-out 6.532 APE11-dist-in 9.295 APE10-dist-in 7.491 APE9-dist-out 8.169 None None None XRAY 3.15 0.163 0.218 A 348 345 0 0 0 0 [[27, 311]] 1.0 7cga Homo sapiens CMGC_MAPK12_HUMAN CMGC 4.7e-85 291.4 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
MK12_HUMAN 6UNAA P53778 10 351 367.0 No_ligand No_ligand Inactive DFGin 4.688 14.348 BLBplus -119.22, 158.65 56.88, 54.29 -106.73, 143.29 55.57, 87.52 77.47, -10.4 in-in in 9.304 Saltbr-in 2.938 HRD-in -70.3, -54.18 80.54, -18.41 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -43.48 APE8-dihe-out -98.96, -53.24 APE8-rot-out 36.51 APE67-dihe-in -67.95, -19.14 -119.83, 10.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.257 Q31R None None XRAY 2.554 0.198 0.245 A 361 329 11 0 0 11 [[27, 311]] 1.0 6una Homo sapiens CMGC_MAPK12_HUMAN CMGC 3.7e-85 291.7 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
MK12_HUMAN 6UNAB P53778 9 351 367.0 No_ligand No_ligand Inactive DFGin 4.551 13.878 BLBplus -121.26, 156.28 59.95, 55.75 -100.45, 141.03 54.7, 95.97 -138.82, -13.73 in-in in 8.974 Saltbr-in 2.656 HRD-in -69.85, -53.43 80.9, -19.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.32 APE8-dihe-in -102.04, 126.27 APE8-rot-out 36.5 APE67-dihe-in -64.94, -15.57 -104.48, -13.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.439 Q31R None None XRAY 2.554 0.198 0.245 B 361 331 12 0 0 12 [[27, 311]] 1.0 6una Homo sapiens CMGC_MAPK12_HUMAN CMGC 3.7e-85 291.7 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12

CMGC_MAPK12 (Mitogen-activated protein kinase 12)

Total number of chains: 0
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name