| Gene | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAPK12 | 1CM8A | P53778 | 8 | 353 | 367.0 | ANP:60400 | ATPlike | Active | DFGin | 6.9648 | 14.7742 | BLAminus | -109.08, -177.81 | 49.88, 82.62 | -94.66, 21.96 | 279.65, 74.31 | -61.38, -21.21 | in-in | in | 9.0 | Saltbr-in | 2.7767 | HRD-in | -80.35, -48.18 | 64.34, 20.91 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.7927 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -132.88, 159.85 | APE9-dihe-na | 73.62, 141.22 | APE8-dihe-in | -70.32, 134.6 | APE8-rot-in | 295.09 | APE67-dihe-in | -62.17, -12.08 | -34.13, -61.33 | APE12-dist-in | 11.6036 | APE11-dist-in | 10.9558 | APE10-dist-in | 6.9911 | APE9-dist-in | 3.072 | None | TPO183,PTR185 | TPO183,PTR185 | XRAY | 2.4 | 0.232 | 0.283 | A | 367.0 | 329.0 | 6 | 25 | 25 | 0 | [[27, 311]] | 1.0 | 1cm8 | CMGC_MAPK12_HUMAN | CMGC | 5.6e-85 | 291.2 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | 1CM8B | P53778 | 8 | 353 | 367.0 | ANP:61400 | ATPlike | Active | DFGin | 6.9649 | 14.7941 | BLAminus | -106.93, -177.79 | 50.51, 81.99 | -94.3, 22.09 | 279.91, 74.94 | -61.07, -21.75 | in-in | in | 9.0314 | Saltbr-in | 2.7588 | HRD-in | -80.7, -47.04 | 63.03, 19.82 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8171 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -132.88, 160.62 | APE9-dihe-na | 73.12, 141.25 | APE8-dihe-in | -70.38, 133.34 | APE8-rot-in | 295.67 | APE67-dihe-in | -62.05, -11.85 | -33.55, -61.0 | APE12-dist-in | 11.6132 | APE11-dist-in | 10.95 | APE10-dist-in | 6.9956 | APE9-dist-in | 3.0483 | None | TPO183,PTR185 | TPO183,PTR185 | XRAY | 2.4 | 0.232 | 0.283 | B | 367.0 | 329.0 | 6 | 25 | 25 | 0 | [[27, 311]] | 1.0 | 1cm8 | CMGC_MAPK12_HUMAN | CMGC | 5.6e-85 | 291.2 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | AF-P53778-K1A | P53778 | 19 | 319 | 367.0 | No_ligand | No_ligand | Active | DFGin | 6.942 | 14.5801 | BLAminus | -114.74, 171.49 | 59.55, 70.2 | -81.36, 15.32 | 288.02, 85.0 | -61.25, -29.33 | in-in | in | 9.0711 | Saltbr-in | 2.6529 | HRD-in | -75.03, -49.4 | 63.95, 16.94 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.887 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -111.53, 169.25 | APE9-dihe-na | 64.71, 138.58 | APE8-dihe-in | -57.41, 128.64 | APE8-rot-in | 298.8 | APE67-dihe-in | -69.45, -18.41 | -45.26, -45.85 | APE12-dist-in | 11.2922 | APE11-dist-in | 11.3371 | APE10-dist-in | 6.9597 | APE9-dist-in | 3.1547 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 301.0 | 301.0 | 0 | 25 | 25 | 0 | [[27, 311]] | 1.0 | AF-P53778-K1 | CMGC_MAPK12_HUMAN | CMGC | 2.7e-85 | 292.1 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | AF-P53778-K3A | P53778 | 19 | 319 | 367.0 | No_ligand | No_ligand | Active | DFGin | 6.6544 | 14.4129 | BLAminus | -117.05, 172.87 | 62.36, 62.32 | -74.09, 13.82 | 287.94, 79.39 | -62.76, -22.02 | in-in | in | 9.4048 | Saltbr-in | 2.7182 | HRD-in | -73.87, -45.92 | 63.52, 15.65 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8434 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -83.66, 170.51 | APE9-dihe-na | 63.91, 132.83 | APE8-dihe-in | -56.22, 129.24 | APE8-rot-in | 295.98 | APE67-dihe-in | -70.87, -16.95 | -43.53, -47.75 | APE12-dist-in | 10.9428 | APE11-dist-in | 10.8558 | APE10-dist-in | 6.5565 | APE9-dist-in | 3.1513 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 301.0 | 301.0 | 0 | 25 | 25 | 0 | [[27, 311]] | 1.0 | AF-P53778-K3 | CMGC_MAPK12_HUMAN | CMGC | 2.7e-85 | 292.1 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | 7CGAB | P53778 | 9 | 353 | 367.0 | No_ligand | No_ligand | Inactive | DFGin | 6.2718 | 14.9689 | ABAminus | -110.86, -62.49 | -102.64, 106.93 | -94.38, 23.15 | 281.27, 88.51 | -76.7, -25.42 | in-in | in | 9.3125 | Saltbr-in | 2.6948 | HRD-out | -79.77, 114.92 | -94.73, 10.19 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.832 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_oiio | APE10-dihe-na | -57.15, 115.35 | APE9-dihe-na | -85.53, -51.12 | APE8-dihe-in | -51.2, 127.61 | APE8-rot-in | 312.11 | APE67-dihe-in | -63.98, -37.1 | -91.4, -47.81 | APE12-dist-out | 6.5497 | APE11-dist-in | 9.4177 | APE10-dist-in | 7.485 | APE9-dist-out | 8.2712 | None | None | None | XRAY | 3.15 | 0.163 | 0.218 | B | 348.0 | 345.0 | 0 | 25 | 25 | 0 | [[27, 311]] | 1.0 | 7cga | CMGC_MAPK12_HUMAN | CMGC | 4.7e-85 | 291.4 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | 7CGAC | P53778 | 9 | 353 | 367.0 | No_ligand | No_ligand | Inactive | DFGin | 6.7758 | 15.0681 | ABAminus | -115.28, -58.81 | -110.37, 107.81 | -95.19, 9.49 | 276.0, 86.92 | -68.22, -14.79 | in-in | in | 9.0832 | Saltbr-in | 3.2179 | HRD-out | -52.52, 150.85 | -125.06, 11.69 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.8531 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_oiio | APE10-dihe-na | -70.64, 118.03 | APE9-dihe-na | -84.55, -56.95 | APE8-dihe-in | -38.51, 120.41 | APE8-rot-in | 307.31 | APE67-dihe-in | -68.67, -38.99 | -90.47, -46.68 | APE12-dist-out | 6.852 | APE11-dist-in | 9.3038 | APE10-dist-in | 7.744 | APE9-dist-out | 8.3788 | None | None | None | XRAY | 3.15 | 0.163 | 0.218 | C | 348.0 | 345.0 | 0 | 25 | 25 | 0 | [[27, 311]] | 1.0 | 7cga | CMGC_MAPK12_HUMAN | CMGC | 4.7e-85 | 291.4 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | 7CGAD | P53778 | 9 | 353 | 367.0 | No_ligand | No_ligand | Inactive | DFGin | 6.6849 | 14.6524 | ABAminus | -119.58, -46.64 | -112.32, 106.79 | -92.17, 3.91 | 283.23, 103.54 | -68.25, -11.35 | in-in | in | 8.9869 | Saltbr-in | 2.679 | HRD-out | -90.17, 97.99 | -84.21, 7.22 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.9232 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_oiio | APE10-dihe-na | -63.92, 117.14 | APE9-dihe-na | -85.66, -57.65 | APE8-dihe-in | -38.77, 133.64 | APE8-rot-in | 316.55 | APE67-dihe-in | -82.55, -28.14 | -108.44, -27.55 | APE12-dist-out | 6.9459 | APE11-dist-in | 9.4335 | APE10-dist-in | 7.7607 | APE9-dist-out | 8.5912 | None | None | None | XRAY | 3.15 | 0.163 | 0.218 | D | 348.0 | 345.0 | 0 | 25 | 25 | 0 | [[27, 311]] | 1.0 | 7cga | CMGC_MAPK12_HUMAN | CMGC | 4.7e-85 | 291.4 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | 7CGAA | P53778 | 9 | 353 | 367.0 | No_ligand | No_ligand | Inactive | DFGin | 6.5112 | 14.8034 | BLAminus | -102.95, 174.14 | 60.25, 88.75 | -98.15, 16.52 | 279.5, 81.2 | -76.27, -1.53 | in-in | in | 8.695 | Saltbr-in | 3.1003 | HRD-in | -69.44, -53.9 | 82.33, -6.84 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.9193 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_oiio | APE10-dihe-na | -80.58, 119.04 | APE9-dihe-na | -87.45, -57.23 | APE8-dihe-in | -48.06, 132.7 | APE8-rot-in | 311.02 | APE67-dihe-in | -70.61, -33.55 | -106.57, -39.76 | APE12-dist-out | 6.5319 | APE11-dist-in | 9.2949 | APE10-dist-in | 7.4909 | APE9-dist-out | 8.1688 | None | None | None | XRAY | 3.15 | 0.163 | 0.218 | A | 348.0 | 345.0 | 0 | 25 | 25 | 0 | [[27, 311]] | 1.0 | 7cga | CMGC_MAPK12_HUMAN | CMGC | 4.7e-85 | 291.4 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | 6UNAA | P53778 | 10 | 351 | 367.0 | No_ligand | No_ligand | Inactive | DFGin | 4.688 | 14.3477 | BLBplus | -119.22, 158.65 | 56.88, 54.29 | -106.73, 143.29 | 55.57, 87.52 | 77.47, -10.4 | in-in | in | 9.3042 | Saltbr-in | 2.9375 | HRD-in | -70.3, -54.18 | 80.54, -18.41 | in-none-out | SNCino | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | nonTYR | APEdihe_aaooi | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, -43.48 | APE8-dihe-out | -98.96, -53.24 | APE8-rot-out | 36.51 | APE67-dihe-in | -67.95, -19.14 | -119.83, 10.68 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 11.2572 | Q31R | None | None | XRAY | 2.554 | 0.198 | 0.245 | A | 361.0 | 329.0 | 11 | 25 | 14 | 11 | [[27, 311]] | 1.0 | 6una | CMGC_MAPK12_HUMAN | CMGC | 3.7e-85 | 291.7 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | 6UNAB | P53778 | 9 | 351 | 367.0 | No_ligand | No_ligand | Inactive | DFGin | 4.5506 | 13.8783 | BLBplus | -121.26, 156.28 | 59.95, 55.75 | -100.45, 141.03 | 54.7, 95.97 | -138.82, -13.73 | in-in | in | 8.9736 | Saltbr-in | 2.6564 | HRD-in | -69.85, -53.43 | 80.9, -19.31 | in-none-out | SNCino | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 132.32 | APE8-dihe-in | -102.04, 126.27 | APE8-rot-out | 36.5 | APE67-dihe-in | -64.94, -15.57 | -104.48, -13.18 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 11.4392 | Q31R | None | None | XRAY | 2.554 | 0.198 | 0.245 | B | 361.0 | 331.0 | 12 | 25 | 13 | 12 | [[27, 311]] | 1.0 | 6una | CMGC_MAPK12_HUMAN | CMGC | 3.7e-85 | 291.7 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAPK12 | MK12_HUMAN | 1CM8A | P53778 | 8 | 353 | 367.0 | ANP:60400 | ATPlike | Active | DFGin | 6.9648 | 14.7742 | BLAminus | -109.08, -177.81 | 49.88, 82.62 | -94.66, 21.96 | 279.65, 74.31 | -61.38, -21.21 | in-in | in | 9.0 | Saltbr-in | 2.7767 | HRD-in | -80.35, -48.18 | 64.34, 20.91 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.7927 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -132.88, 159.85 | APE9-dihe-na | 73.62, 141.22 | APE8-dihe-in | -70.32, 134.6 | APE8-rot-in | 295.09 | APE67-dihe-in | -62.17, -12.08 | -34.13, -61.33 | APE12-dist-in | 11.6036 | APE11-dist-in | 10.9558 | APE10-dist-in | 6.9911 | APE9-dist-in | 3.072 | None | TPO183,PTR185 | TPO183,PTR185 | XRAY | 2.4 | 0.232 | 0.283 | A | 367.0 | 329.0 | 6 | 25 | 25 | 0 | [[27, 311]] | 1.0 | 1cm8 | Homo sapiens | CMGC_MAPK12_HUMAN | CMGC | 5.6e-85 | 291.2 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | MK12_HUMAN | 1CM8B | P53778 | 8 | 353 | 367.0 | ANP:61400 | ATPlike | Active | DFGin | 6.9649 | 14.7941 | BLAminus | -106.93, -177.79 | 50.51, 81.99 | -94.3, 22.09 | 279.91, 74.94 | -61.07, -21.75 | in-in | in | 9.0314 | Saltbr-in | 2.7588 | HRD-in | -80.7, -47.04 | 63.03, 19.82 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8171 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -132.88, 160.62 | APE9-dihe-na | 73.12, 141.25 | APE8-dihe-in | -70.38, 133.34 | APE8-rot-in | 295.67 | APE67-dihe-in | -62.05, -11.85 | -33.55, -61.0 | APE12-dist-in | 11.6132 | APE11-dist-in | 10.95 | APE10-dist-in | 6.9956 | APE9-dist-in | 3.0483 | None | TPO183,PTR185 | TPO183,PTR185 | XRAY | 2.4 | 0.232 | 0.283 | B | 367.0 | 329.0 | 6 | 25 | 25 | 0 | [[27, 311]] | 1.0 | 1cm8 | Homo sapiens | CMGC_MAPK12_HUMAN | CMGC | 5.6e-85 | 291.2 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | MK12_HUMAN | AF-P53778-K1A | P53778 | 19 | 319 | 367.0 | No_ligand | No_ligand | Active | DFGin | 6.942 | 14.5801 | BLAminus | -114.74, 171.49 | 59.55, 70.2 | -81.36, 15.32 | 288.02, 85.0 | -61.25, -29.33 | in-in | in | 9.0711 | Saltbr-in | 2.6529 | HRD-in | -75.03, -49.4 | 63.95, 16.94 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.887 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -111.53, 169.25 | APE9-dihe-na | 64.71, 138.58 | APE8-dihe-in | -57.41, 128.64 | APE8-rot-in | 298.8 | APE67-dihe-in | -69.45, -18.41 | -45.26, -45.85 | APE12-dist-in | 11.2922 | APE11-dist-in | 11.3371 | APE10-dist-in | 6.9597 | APE9-dist-in | 3.1547 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 301.0 | 301.0 | 0 | 25 | 25 | 0 | [[27, 311]] | 1.0 | AF-P53778-K1 | Homo sapiens | CMGC_MAPK12_HUMAN | CMGC | 2.7e-85 | 292.1 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | MK12_HUMAN | AF-P53778-K3A | P53778 | 19 | 319 | 367.0 | No_ligand | No_ligand | Active | DFGin | 6.6544 | 14.4129 | BLAminus | -117.05, 172.87 | 62.36, 62.32 | -74.09, 13.82 | 287.94, 79.39 | -62.76, -22.02 | in-in | in | 9.4048 | Saltbr-in | 2.7182 | HRD-in | -73.87, -45.92 | 63.52, 15.65 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8434 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -83.66, 170.51 | APE9-dihe-na | 63.91, 132.83 | APE8-dihe-in | -56.22, 129.24 | APE8-rot-in | 295.98 | APE67-dihe-in | -70.87, -16.95 | -43.53, -47.75 | APE12-dist-in | 10.9428 | APE11-dist-in | 10.8558 | APE10-dist-in | 6.5565 | APE9-dist-in | 3.1513 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 301.0 | 301.0 | 0 | 25 | 25 | 0 | [[27, 311]] | 1.0 | AF-P53778-K3 | Homo sapiens | CMGC_MAPK12_HUMAN | CMGC | 2.7e-85 | 292.1 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | MK12_HUMAN | 7CGAB | P53778 | 9 | 353 | 367.0 | No_ligand | No_ligand | Inactive | DFGin | 6.2718 | 14.9689 | ABAminus | -110.86, -62.49 | -102.64, 106.93 | -94.38, 23.15 | 281.27, 88.51 | -76.7, -25.42 | in-in | in | 9.3125 | Saltbr-in | 2.6948 | HRD-out | -79.77, 114.92 | -94.73, 10.19 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.832 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_oiio | APE10-dihe-na | -57.15, 115.35 | APE9-dihe-na | -85.53, -51.12 | APE8-dihe-in | -51.2, 127.61 | APE8-rot-in | 312.11 | APE67-dihe-in | -63.98, -37.1 | -91.4, -47.81 | APE12-dist-out | 6.5497 | APE11-dist-in | 9.4177 | APE10-dist-in | 7.485 | APE9-dist-out | 8.2712 | None | None | None | XRAY | 3.15 | 0.163 | 0.218 | B | 348.0 | 345.0 | 0 | 25 | 25 | 0 | [[27, 311]] | 1.0 | 7cga | Homo sapiens | CMGC_MAPK12_HUMAN | CMGC | 4.7e-85 | 291.4 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | MK12_HUMAN | 7CGAC | P53778 | 9 | 353 | 367.0 | No_ligand | No_ligand | Inactive | DFGin | 6.7758 | 15.0681 | ABAminus | -115.28, -58.81 | -110.37, 107.81 | -95.19, 9.49 | 276.0, 86.92 | -68.22, -14.79 | in-in | in | 9.0832 | Saltbr-in | 3.2179 | HRD-out | -52.52, 150.85 | -125.06, 11.69 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.8531 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_oiio | APE10-dihe-na | -70.64, 118.03 | APE9-dihe-na | -84.55, -56.95 | APE8-dihe-in | -38.51, 120.41 | APE8-rot-in | 307.31 | APE67-dihe-in | -68.67, -38.99 | -90.47, -46.68 | APE12-dist-out | 6.852 | APE11-dist-in | 9.3038 | APE10-dist-in | 7.744 | APE9-dist-out | 8.3788 | None | None | None | XRAY | 3.15 | 0.163 | 0.218 | C | 348.0 | 345.0 | 0 | 25 | 25 | 0 | [[27, 311]] | 1.0 | 7cga | Homo sapiens | CMGC_MAPK12_HUMAN | CMGC | 4.7e-85 | 291.4 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | MK12_HUMAN | 7CGAD | P53778 | 9 | 353 | 367.0 | No_ligand | No_ligand | Inactive | DFGin | 6.6849 | 14.6524 | ABAminus | -119.58, -46.64 | -112.32, 106.79 | -92.17, 3.91 | 283.23, 103.54 | -68.25, -11.35 | in-in | in | 8.9869 | Saltbr-in | 2.679 | HRD-out | -90.17, 97.99 | -84.21, 7.22 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.9232 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_oiio | APE10-dihe-na | -63.92, 117.14 | APE9-dihe-na | -85.66, -57.65 | APE8-dihe-in | -38.77, 133.64 | APE8-rot-in | 316.55 | APE67-dihe-in | -82.55, -28.14 | -108.44, -27.55 | APE12-dist-out | 6.9459 | APE11-dist-in | 9.4335 | APE10-dist-in | 7.7607 | APE9-dist-out | 8.5912 | None | None | None | XRAY | 3.15 | 0.163 | 0.218 | D | 348.0 | 345.0 | 0 | 25 | 25 | 0 | [[27, 311]] | 1.0 | 7cga | Homo sapiens | CMGC_MAPK12_HUMAN | CMGC | 4.7e-85 | 291.4 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | MK12_HUMAN | 7CGAA | P53778 | 9 | 353 | 367.0 | No_ligand | No_ligand | Inactive | DFGin | 6.5112 | 14.8034 | BLAminus | -102.95, 174.14 | 60.25, 88.75 | -98.15, 16.52 | 279.5, 81.2 | -76.27, -1.53 | in-in | in | 8.695 | Saltbr-in | 3.1003 | HRD-in | -69.44, -53.9 | 82.33, -6.84 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.9193 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_oiio | APE10-dihe-na | -80.58, 119.04 | APE9-dihe-na | -87.45, -57.23 | APE8-dihe-in | -48.06, 132.7 | APE8-rot-in | 311.02 | APE67-dihe-in | -70.61, -33.55 | -106.57, -39.76 | APE12-dist-out | 6.5319 | APE11-dist-in | 9.2949 | APE10-dist-in | 7.4909 | APE9-dist-out | 8.1688 | None | None | None | XRAY | 3.15 | 0.163 | 0.218 | A | 348.0 | 345.0 | 0 | 25 | 25 | 0 | [[27, 311]] | 1.0 | 7cga | Homo sapiens | CMGC_MAPK12_HUMAN | CMGC | 4.7e-85 | 291.4 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | MK12_HUMAN | 6UNAA | P53778 | 10 | 351 | 367.0 | No_ligand | No_ligand | Inactive | DFGin | 4.688 | 14.3477 | BLBplus | -119.22, 158.65 | 56.88, 54.29 | -106.73, 143.29 | 55.57, 87.52 | 77.47, -10.4 | in-in | in | 9.3042 | Saltbr-in | 2.9375 | HRD-in | -70.3, -54.18 | 80.54, -18.41 | in-none-out | SNCino | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | nonTYR | APEdihe_aaooi | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, -43.48 | APE8-dihe-out | -98.96, -53.24 | APE8-rot-out | 36.51 | APE67-dihe-in | -67.95, -19.14 | -119.83, 10.68 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 11.2572 | Q31R | None | None | XRAY | 2.554 | 0.198 | 0.245 | A | 361.0 | 329.0 | 11 | 25 | 14 | 11 | [[27, 311]] | 1.0 | 6una | Homo sapiens | CMGC_MAPK12_HUMAN | CMGC | 3.7e-85 | 291.7 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| MAPK12 | MK12_HUMAN | 6UNAB | P53778 | 9 | 351 | 367.0 | No_ligand | No_ligand | Inactive | DFGin | 4.5506 | 13.8783 | BLBplus | -121.26, 156.28 | 59.95, 55.75 | -100.45, 141.03 | 54.7, 95.97 | -138.82, -13.73 | in-in | in | 8.9736 | Saltbr-in | 2.6564 | HRD-in | -69.85, -53.43 | 80.9, -19.31 | in-none-out | SNCino | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 132.32 | APE8-dihe-in | -102.04, 126.27 | APE8-rot-out | 36.5 | APE67-dihe-in | -64.94, -15.57 | -104.48, -13.18 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 11.4392 | Q31R | None | None | XRAY | 2.554 | 0.198 | 0.245 | B | 361.0 | 331.0 | 12 | 25 | 13 | 12 | [[27, 311]] | 1.0 | 6una | Homo sapiens | CMGC_MAPK12_HUMAN | CMGC | 3.7e-85 | 291.7 | 1.0 | 301.0 | 301.0 | 170 | 171 | 172 | 174 | 176 | 56 | 74 | 78 | 150 | 152 | 151 | 153.0 | 208 | 195 | 190 | 189 | 188 | 187 | 186 | 185 | 184 | 110 | Mitogen-activated protein kinase 12 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|