KinCore

TKL_MAP3K20 (Mitogen-activated protein kinase kinase kinase 20)

Total number of chains: 12

Active chains: 2

Uniprot: M3K20_HUMAN

Kinase Domain Residues: 16 - 262

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAplus	10	83.3%	6JUUA
DFGin	BLAminus	2	16.7%	AF-Q9NYL2-K1A

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PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein
AF-Q9NYL2-K1A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	8 - 270	0	None	None	Mitogen-activated protein kinase kinase kinase 20
AF-Q9NYL2-K3A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	8 - 270	0	None	None	Mitogen-activated protein kinase kinase kinase 20
5HESB	2.14	Inactive	DFGin‑BLAplus	out-out	none-out	nonTYR	APEdihe_aaoii	APEdist_nnno	032	Type1	7 - 298	0	TPO161	None	Mitogen-activated protein kinase kinase kinase 20
5HESA	2.14	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaooi	APEdist_nnno	032	Type1.5_Back	6 - 299	0	TPO161	None	Mitogen-activated protein kinase kinase kinase 20
5X5OA	1.868	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaoii	APEdist_oioo	7Z0	Type1.5_Back	8 - 299	0	None	None	Mitogen-activated protein kinase kinase kinase 20
6JUTA	2.1	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaoii	APEdist_iioo	C9O	Type1.5_Back	8 - 304	0	None	None	Mitogen-activated protein kinase kinase kinase 20
6JUUA	1.903	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaoii	APEdist_oioo	C9R	Type1.5_Back	8 - 299	0	None	None	Mitogen-activated protein kinase kinase kinase 20
7YAWA	2.1	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaooi	APEdist_oioo	IGS	Type1.5_Back	8 - 299	0	None	None	Mitogen-activated protein kinase kinase kinase 20
7YAWD	2.1	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaooi	APEdist_oooo	IGS	Type1.5_Back	8 - 299	0	None	None	Mitogen-activated protein kinase kinase kinase 20
7YAZA	2.54	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaoii	APEdist_oioo	IGV	Type1.5_Back	8 - 299	0	None	None	Mitogen-activated protein kinase kinase kinase 20
7YAWB	2.1	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaooi	APEdist_oooo	IGS	Type1.5_Front	8 - 299	0	None	None	Mitogen-activated protein kinase kinase kinase 20
7YAWC	2.1	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaoii	APEdist_oioo	IGS	Type1.5_Front	8 - 299	0	None	None	Mitogen-activated protein kinase kinase kinase 20

TKL_MAP3K20 (Mitogen-activated protein kinase kinase kinase 20)

Total number of chains: 12

Active chains: 2

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAplus	10	83.3%	6JUUA
DFGin	BLAminus	2	16.7%	AF-Q9NYL2-K1A

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UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism
M3K20_HUMAN	AF-Q9NYL2-K1A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	8 - 270	0	None	None	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens
M3K20_HUMAN	AF-Q9NYL2-K3A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	8 - 270	0	None	None	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens
M3K20_HUMAN	5HESB	2.14	Inactive	DFGin‑BLAplus	out-out	none-out	nonTYR	APEdihe_aaoii	APEdist_nnno	032	Type1	7 - 298	0	TPO161	None	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens
M3K20_HUMAN	5HESA	2.14	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaooi	APEdist_nnno	032	Type1.5_Back	6 - 299	0	TPO161	None	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens
M3K20_HUMAN	5X5OA	1.868	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaoii	APEdist_oioo	7Z0	Type1.5_Back	8 - 299	0	None	None	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens
M3K20_HUMAN	6JUTA	2.1	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaoii	APEdist_iioo	C9O	Type1.5_Back	8 - 304	0	None	None	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens
M3K20_HUMAN	6JUUA	1.903	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaoii	APEdist_oioo	C9R	Type1.5_Back	8 - 299	0	None	None	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens
M3K20_HUMAN	7YAWA	2.1	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaooi	APEdist_oioo	IGS	Type1.5_Back	8 - 299	0	None	None	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens
M3K20_HUMAN	7YAWD	2.1	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaooi	APEdist_oooo	IGS	Type1.5_Back	8 - 299	0	None	None	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens
M3K20_HUMAN	7YAZA	2.54	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaoii	APEdist_oioo	IGV	Type1.5_Back	8 - 299	0	None	None	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens
M3K20_HUMAN	7YAWB	2.1	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaooi	APEdist_oooo	IGS	Type1.5_Front	8 - 299	0	None	None	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens
M3K20_HUMAN	7YAWC	2.1	Inactive	DFGin‑BLAplus	out-out	out-out	nonTYR	APEdihe_aaoii	APEdist_oioo	IGS	Type1.5_Front	8 - 299	0	None	None	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens

TKL_MAP3K20 (Mitogen-activated protein kinase kinase kinase 20)

Total number of chains: 0

Active chains: 0

Spatial label	Dihedral label	Number of Chains	Percent	Representative

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UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism