TKL_MAP3K20 (Mitogen-activated protein kinase kinase kinase 20)

Total number of chains: 12
Active chains: 2
Uniprot: M3K20_HUMAN
Kinase Domain Residues: 16 - 262
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 10 83.3% 6JUUA
DFGin BLAminus 2 16.7% AF-Q9NYL2-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K20 AF-Q9NYL2-K1A Q9NYL2 8 270 800.0 No_ligand No_ligand Active DFGin 6.6807 13.8724 BLAminus -136.88, -179.15 60.84, 76.08 -90.77, 16.25 289.28, 81.4 -62.28, -33.23 in-in in 8.2088 Saltbr-in 2.7695 HRD-in -72.24, -49.06 71.31, -9.71 in-in-in SNCiii in-in ActLoopNT-in 2.9445 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.51, 142.14 APE9-dihe-na 124.77, -163.41 APE8-dihe-in -116.24, 119.4 APE8-rot-in 317.66 APE67-dihe-in -59.17, -24.37 -45.63, -45.28 APE12-dist-in 8.9825 APE11-dist-in 11.0969 APE10-dist-in 5.1698 APE9-dist-in 4.1799 None None None AF2 -1.0 1.0 1.0 A 263.0 263.0 0 26 26 0 [[16, 262]] 1.0 AF-Q9NYL2-K1 TKL_MAP3K20_HUMAN TKL 6.7e-79 271.2 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 AF-Q9NYL2-K3A Q9NYL2 8 270 800.0 No_ligand No_ligand Active DFGin 6.1896 13.8169 BLAminus -138.36, -178.08 56.55, 77.69 -87.2, 15.12 295.14, 83.57 -61.15, -31.92 in-in in 7.9646 Saltbr-in 2.6636 HRD-in -73.83, -47.11 67.36, -8.84 in-in-in SNCiii in-in ActLoopNT-in 3.0738 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.7, 129.72 APE9-dihe-na 138.72, -163.73 APE8-dihe-in -129.0, 115.06 APE8-rot-in 318.5 APE67-dihe-in -59.32, -21.0 -45.29, -45.91 APE12-dist-in 8.3608 APE11-dist-in 10.8509 APE10-dist-in 4.9224 APE9-dist-in 4.0546 None None None AF2 -1.0 1.0 1.0 A 263.0 263.0 0 26 26 0 [[16, 262]] 1.0 AF-Q9NYL2-K3 TKL_MAP3K20_HUMAN TKL 6.7e-79 271.2 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 5HESB Q9NYL2 7 298 800.0 032:401 Type1 Inactive DFGin 6.4097 13.0233 BLAplus -143.58, 177.64 72.44, 21.16 -87.16, -28.78 42.57, 80.13 -79.68, 999.0 out-out out 13.6139 Saltbr-out 12.2528 HRD-in -72.66, -57.27 76.35, 0.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -8.17 APE8-dihe-out -112.48, -1.68 APE8-rot-in 299.88 APE67-dihe-in -59.28, -26.85 -56.83, -32.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6111 None TPO161 TPO161 XRAY 2.14 0.18 0.226 B 307.0 278.0 14 26 12 14 [[16, 262]] 1.0 5hes TKL_MAP3K20_HUMAN TKL 1.2e-78 270.5 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 5HESA Q9NYL2 6 299 800.0 032:401 Type1.5_Back Inactive DFGin 6.5083 12.9465 BLAplus -149.3, -178.78 72.05, 18.35 -79.29, -13.47 42.54, 81.81 -105.89, 8.43 out-out out 10.3272 Saltbr-out 7.9101 HRD-in -63.65, -61.5 81.63, -14.81 out-out-out SNCooo out-out ActLoopNT-out 8.5311 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.01 APE8-dihe-out -130.74, 34.59 APE8-rot-out 64.32 APE67-dihe-in -59.25, -25.49 -57.81, -30.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.632 None TPO161 TPO161 XRAY 2.14 0.18 0.226 A 307.0 288.0 6 26 20 6 [[16, 262]] 1.0 5hes TKL_MAP3K20_HUMAN TKL 1.2e-78 270.5 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 5X5OA Q9NYL2 8 299 800.0 7Z0:401 Type1.5_Back Inactive DFGin 6.6267 12.6386 BLAplus -111.05, 164.5 66.24, 16.91 -68.57, -10.61 52.5, 81.11 -102.97, -3.56 out-out out 16.6947 Saltbr-out 18.2682 HRD-in -63.84, -52.27 74.76, -10.99 out-out-out SNCooo out-out ActLoopNT-out 6.2439 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -59.51, -46.06 APE9-dihe-na -52.38, -30.92 APE8-dihe-out -90.44, -13.44 APE8-rot-in 307.92 APE67-dihe-in -53.82, -26.39 -56.83, -35.18 APE12-dist-out 15.3405 APE11-dist-in 13.7836 APE10-dist-out 18.442 APE9-dist-out 12.0426 None None None XRAY 1.868 0.192 0.226 A 310.0 291.0 1 26 25 1 [[16, 262]] 1.0 5x5o TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 6JUTA Q9NYL2 8 304 800.0 C9O:401 Type1.5_Back Inactive DFGin 6.1481 12.6624 BLAplus -114.7, 160.54 66.2, 27.22 -75.05, -8.98 54.77, 76.79 -98.32, -6.07 out-out out 13.2896 Saltbr-out 13.7244 HRD-in -61.65, -58.69 73.8, -5.87 out-out-out SNCooo out-out ActLoopNT-out 6.1187 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -57.82, 127.21 APE9-dihe-na 91.36, -5.91 APE8-dihe-out -116.32, -16.6 APE8-rot-in 301.48 APE67-dihe-in -58.74, -27.01 -46.23, -39.09 APE12-dist-in 10.7442 APE11-dist-in 13.6307 APE10-dist-out 16.8001 APE9-dist-out 12.098 None None None XRAY 2.1 0.181 0.222 A 310.0 297.0 0 26 26 0 [[16, 262]] 1.0 6jut TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 6JUUA Q9NYL2 8 299 800.0 C9R:401 Type1.5_Back Inactive DFGin 6.5449 12.5212 BLAplus -115.43, 157.64 70.58, 18.67 -63.52, -23.08 56.3, 81.41 -96.97, -0.08 out-out out 17.0312 Saltbr-out 18.8425 HRD-in -69.4, -60.75 82.42, -9.38 out-out-out SNCooo out-out ActLoopNT-out 6.4432 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -60.51, -41.04 APE9-dihe-na -59.26, -31.61 APE8-dihe-out -82.47, -8.82 APE8-rot-in 313.39 APE67-dihe-in -57.15, -29.55 -56.71, -35.8 APE12-dist-out 15.6625 APE11-dist-in 13.2716 APE10-dist-out 18.1465 APE9-dist-out 12.192 None None None XRAY 1.903 0.168 0.21 A 310.0 292.0 0 26 26 0 [[16, 262]] 1.0 6juu TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 7YAWA Q9NYL2 8 299 800.0 IGS:60401 Type1.5_Back Inactive DFGin 6.6366 12.5628 BLAplus -107.37, 162.77 70.01, 25.25 -77.69, -20.79 49.78, 78.58 -92.33, -4.17 out-out out 16.9522 Saltbr-out 16.8243 HRD-in -66.81, -58.39 69.73, -5.3 out-out-out SNCooo out-out ActLoopNT-out 5.3454 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -136.19, -36.14 APE9-dihe-na -87.34, 25.43 APE8-dihe-out -120.09, -23.77 APE8-rot-out 63.21 APE67-dihe-in -58.2, -27.12 -48.71, -41.35 APE12-dist-out 16.1855 APE11-dist-in 13.7792 APE10-dist-out 18.6507 APE9-dist-out 12.1535 None None None XRAY 2.1 0.208 0.243 A 310.0 291.0 1 26 25 1 [[16, 262]] 1.0 7yaw TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 7YAWD Q9NYL2 8 299 800.0 IGS:60401 Type1.5_Back Inactive DFGin 6.0387 12.3501 BLAplus -110.86, 162.98 67.32, 26.82 -75.01, -16.27 51.63, 85.42 -101.64, -3.07 out-out out 16.407 Saltbr-out 12.3921 HRD-in -66.82, -58.27 73.94, -17.87 out-out-out SNCooo out-out ActLoopNT-out 5.8543 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -50.8, -49.33 APE9-dihe-na -74.08, 31.98 APE8-dihe-out -131.38, -38.39 APE8-rot-out 63.81 APE67-dihe-in -59.55, -22.6 -47.42, -42.75 APE12-dist-out 17.8804 APE11-dist-out 14.2837 APE10-dist-out 19.1466 APE9-dist-out 11.9677 None None None XRAY 2.1 0.208 0.243 D 310.0 291.0 1 26 25 1 [[16, 262]] 1.0 7yaw TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 7YAZA Q9NYL2 8 299 800.0 IGV:60401 Type1.5_Back Inactive DFGin 6.4886 12.9093 BLAplus -104.08, 163.07 66.5, 24.72 -76.06, -21.05 52.57, 81.45 -94.77, 8.1 out-out out 17.4485 Saltbr-out 19.2918 HRD-in -74.32, -47.28 68.42, -12.2 out-out-out SNCooo out-out ActLoopNT-out 6.1429 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -76.12, -32.07 APE9-dihe-na -76.2, 4.92 APE8-dihe-out -118.21, -12.07 APE8-rot-in 313.69 APE67-dihe-in -61.46, -21.69 -54.4, -35.57 APE12-dist-out 15.6436 APE11-dist-in 13.4324 APE10-dist-out 18.5772 APE9-dist-out 11.9881 None None None XRAY 2.54 0.187 0.252 A 310.0 291.0 1 26 25 1 [[16, 262]] 1.0 7yaz TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 7YAWB Q9NYL2 8 299 800.0 IGS:60401 Type1.5_Front Inactive DFGin 6.0615 12.8867 BLAplus -112.26, 159.46 66.47, 30.72 -77.06, -4.03 46.81, 82.8 -112.18, 3.53 out-out out 16.1976 Saltbr-out 14.385 HRD-in -68.93, -58.68 76.93, -11.19 out-out-out SNCooo out-out ActLoopNT-out 5.8412 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -56.67, -41.74 APE9-dihe-na -72.55, 0.42 APE8-dihe-out -131.57, -4.4 APE8-rot-out 77.42 APE67-dihe-in -62.57, -21.79 -53.81, -31.98 APE12-dist-out 14.667 APE11-dist-out 14.0274 APE10-dist-out 18.4933 APE9-dist-out 12.4597 None None None XRAY 2.1 0.208 0.243 B 310.0 291.0 1 26 25 1 [[16, 262]] 1.0 7yaw TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 7YAWC Q9NYL2 8 299 800.0 IGS:60401 Type1.5_Front Inactive DFGin 5.6767 12.9838 BLAplus -105.78, 161.9 66.78, 23.82 -68.46, -14.89 48.8, 88.46 -104.69, -15.53 out-out out 16.0889 Saltbr-out 16.0954 HRD-in -71.18, -58.92 73.09, -4.85 out-out-out SNCooo out-out ActLoopNT-out 5.6164 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -67.62, -51.34 APE9-dihe-na -86.7, 18.29 APE8-dihe-out -115.5, -10.48 APE8-rot-in 308.5 APE67-dihe-in -59.14, -22.29 -53.59, -37.71 APE12-dist-out 14.9863 APE11-dist-in 13.9487 APE10-dist-out 18.3728 APE9-dist-out 12.3026 None None None XRAY 2.1 0.208 0.243 C 310.0 291.0 1 26 25 1 [[16, 262]] 1.0 7yaw TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20

TKL_MAP3K20 (Mitogen-activated protein kinase kinase kinase 20)

Total number of chains: 12
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 10 83.3% 6JUUA
DFGin BLAminus 2 16.7% AF-Q9NYL2-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K20 M3K20_HUMAN AF-Q9NYL2-K1A Q9NYL2 8 270 800.0 No_ligand No_ligand Active DFGin 6.6807 13.8724 BLAminus -136.88, -179.15 60.84, 76.08 -90.77, 16.25 289.28, 81.4 -62.28, -33.23 in-in in 8.2088 Saltbr-in 2.7695 HRD-in -72.24, -49.06 71.31, -9.71 in-in-in SNCiii in-in ActLoopNT-in 2.9445 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.51, 142.14 APE9-dihe-na 124.77, -163.41 APE8-dihe-in -116.24, 119.4 APE8-rot-in 317.66 APE67-dihe-in -59.17, -24.37 -45.63, -45.28 APE12-dist-in 8.9825 APE11-dist-in 11.0969 APE10-dist-in 5.1698 APE9-dist-in 4.1799 None None None AF2 -1.0 1.0 1.0 A 263.0 263.0 0 26 26 0 [[16, 262]] 1.0 AF-Q9NYL2-K1 Homo sapiens TKL_MAP3K20_HUMAN TKL 6.7e-79 271.2 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 M3K20_HUMAN AF-Q9NYL2-K3A Q9NYL2 8 270 800.0 No_ligand No_ligand Active DFGin 6.1896 13.8169 BLAminus -138.36, -178.08 56.55, 77.69 -87.2, 15.12 295.14, 83.57 -61.15, -31.92 in-in in 7.9646 Saltbr-in 2.6636 HRD-in -73.83, -47.11 67.36, -8.84 in-in-in SNCiii in-in ActLoopNT-in 3.0738 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.7, 129.72 APE9-dihe-na 138.72, -163.73 APE8-dihe-in -129.0, 115.06 APE8-rot-in 318.5 APE67-dihe-in -59.32, -21.0 -45.29, -45.91 APE12-dist-in 8.3608 APE11-dist-in 10.8509 APE10-dist-in 4.9224 APE9-dist-in 4.0546 None None None AF2 -1.0 1.0 1.0 A 263.0 263.0 0 26 26 0 [[16, 262]] 1.0 AF-Q9NYL2-K3 Homo sapiens TKL_MAP3K20_HUMAN TKL 6.7e-79 271.2 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 M3K20_HUMAN 5HESB Q9NYL2 7 298 800.0 032:401 Type1 Inactive DFGin 6.4097 13.0233 BLAplus -143.58, 177.64 72.44, 21.16 -87.16, -28.78 42.57, 80.13 -79.68, 999.0 out-out out 13.6139 Saltbr-out 12.2528 HRD-in -72.66, -57.27 76.35, 0.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -8.17 APE8-dihe-out -112.48, -1.68 APE8-rot-in 299.88 APE67-dihe-in -59.28, -26.85 -56.83, -32.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6111 None TPO161 TPO161 XRAY 2.14 0.18 0.226 B 307.0 278.0 14 26 12 14 [[16, 262]] 1.0 5hes Homo sapiens TKL_MAP3K20_HUMAN TKL 1.2e-78 270.5 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 M3K20_HUMAN 5HESA Q9NYL2 6 299 800.0 032:401 Type1.5_Back Inactive DFGin 6.5083 12.9465 BLAplus -149.3, -178.78 72.05, 18.35 -79.29, -13.47 42.54, 81.81 -105.89, 8.43 out-out out 10.3272 Saltbr-out 7.9101 HRD-in -63.65, -61.5 81.63, -14.81 out-out-out SNCooo out-out ActLoopNT-out 8.5311 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.01 APE8-dihe-out -130.74, 34.59 APE8-rot-out 64.32 APE67-dihe-in -59.25, -25.49 -57.81, -30.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.632 None TPO161 TPO161 XRAY 2.14 0.18 0.226 A 307.0 288.0 6 26 20 6 [[16, 262]] 1.0 5hes Homo sapiens TKL_MAP3K20_HUMAN TKL 1.2e-78 270.5 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 M3K20_HUMAN 5X5OA Q9NYL2 8 299 800.0 7Z0:401 Type1.5_Back Inactive DFGin 6.6267 12.6386 BLAplus -111.05, 164.5 66.24, 16.91 -68.57, -10.61 52.5, 81.11 -102.97, -3.56 out-out out 16.6947 Saltbr-out 18.2682 HRD-in -63.84, -52.27 74.76, -10.99 out-out-out SNCooo out-out ActLoopNT-out 6.2439 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -59.51, -46.06 APE9-dihe-na -52.38, -30.92 APE8-dihe-out -90.44, -13.44 APE8-rot-in 307.92 APE67-dihe-in -53.82, -26.39 -56.83, -35.18 APE12-dist-out 15.3405 APE11-dist-in 13.7836 APE10-dist-out 18.442 APE9-dist-out 12.0426 None None None XRAY 1.868 0.192 0.226 A 310.0 291.0 1 26 25 1 [[16, 262]] 1.0 5x5o Homo sapiens TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 M3K20_HUMAN 6JUTA Q9NYL2 8 304 800.0 C9O:401 Type1.5_Back Inactive DFGin 6.1481 12.6624 BLAplus -114.7, 160.54 66.2, 27.22 -75.05, -8.98 54.77, 76.79 -98.32, -6.07 out-out out 13.2896 Saltbr-out 13.7244 HRD-in -61.65, -58.69 73.8, -5.87 out-out-out SNCooo out-out ActLoopNT-out 6.1187 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -57.82, 127.21 APE9-dihe-na 91.36, -5.91 APE8-dihe-out -116.32, -16.6 APE8-rot-in 301.48 APE67-dihe-in -58.74, -27.01 -46.23, -39.09 APE12-dist-in 10.7442 APE11-dist-in 13.6307 APE10-dist-out 16.8001 APE9-dist-out 12.098 None None None XRAY 2.1 0.181 0.222 A 310.0 297.0 0 26 26 0 [[16, 262]] 1.0 6jut Homo sapiens TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 M3K20_HUMAN 6JUUA Q9NYL2 8 299 800.0 C9R:401 Type1.5_Back Inactive DFGin 6.5449 12.5212 BLAplus -115.43, 157.64 70.58, 18.67 -63.52, -23.08 56.3, 81.41 -96.97, -0.08 out-out out 17.0312 Saltbr-out 18.8425 HRD-in -69.4, -60.75 82.42, -9.38 out-out-out SNCooo out-out ActLoopNT-out 6.4432 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -60.51, -41.04 APE9-dihe-na -59.26, -31.61 APE8-dihe-out -82.47, -8.82 APE8-rot-in 313.39 APE67-dihe-in -57.15, -29.55 -56.71, -35.8 APE12-dist-out 15.6625 APE11-dist-in 13.2716 APE10-dist-out 18.1465 APE9-dist-out 12.192 None None None XRAY 1.903 0.168 0.21 A 310.0 292.0 0 26 26 0 [[16, 262]] 1.0 6juu Homo sapiens TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 M3K20_HUMAN 7YAWA Q9NYL2 8 299 800.0 IGS:60401 Type1.5_Back Inactive DFGin 6.6366 12.5628 BLAplus -107.37, 162.77 70.01, 25.25 -77.69, -20.79 49.78, 78.58 -92.33, -4.17 out-out out 16.9522 Saltbr-out 16.8243 HRD-in -66.81, -58.39 69.73, -5.3 out-out-out SNCooo out-out ActLoopNT-out 5.3454 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -136.19, -36.14 APE9-dihe-na -87.34, 25.43 APE8-dihe-out -120.09, -23.77 APE8-rot-out 63.21 APE67-dihe-in -58.2, -27.12 -48.71, -41.35 APE12-dist-out 16.1855 APE11-dist-in 13.7792 APE10-dist-out 18.6507 APE9-dist-out 12.1535 None None None XRAY 2.1 0.208 0.243 A 310.0 291.0 1 26 25 1 [[16, 262]] 1.0 7yaw Homo sapiens TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 M3K20_HUMAN 7YAWD Q9NYL2 8 299 800.0 IGS:60401 Type1.5_Back Inactive DFGin 6.0387 12.3501 BLAplus -110.86, 162.98 67.32, 26.82 -75.01, -16.27 51.63, 85.42 -101.64, -3.07 out-out out 16.407 Saltbr-out 12.3921 HRD-in -66.82, -58.27 73.94, -17.87 out-out-out SNCooo out-out ActLoopNT-out 5.8543 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -50.8, -49.33 APE9-dihe-na -74.08, 31.98 APE8-dihe-out -131.38, -38.39 APE8-rot-out 63.81 APE67-dihe-in -59.55, -22.6 -47.42, -42.75 APE12-dist-out 17.8804 APE11-dist-out 14.2837 APE10-dist-out 19.1466 APE9-dist-out 11.9677 None None None XRAY 2.1 0.208 0.243 D 310.0 291.0 1 26 25 1 [[16, 262]] 1.0 7yaw Homo sapiens TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 M3K20_HUMAN 7YAZA Q9NYL2 8 299 800.0 IGV:60401 Type1.5_Back Inactive DFGin 6.4886 12.9093 BLAplus -104.08, 163.07 66.5, 24.72 -76.06, -21.05 52.57, 81.45 -94.77, 8.1 out-out out 17.4485 Saltbr-out 19.2918 HRD-in -74.32, -47.28 68.42, -12.2 out-out-out SNCooo out-out ActLoopNT-out 6.1429 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -76.12, -32.07 APE9-dihe-na -76.2, 4.92 APE8-dihe-out -118.21, -12.07 APE8-rot-in 313.69 APE67-dihe-in -61.46, -21.69 -54.4, -35.57 APE12-dist-out 15.6436 APE11-dist-in 13.4324 APE10-dist-out 18.5772 APE9-dist-out 11.9881 None None None XRAY 2.54 0.187 0.252 A 310.0 291.0 1 26 25 1 [[16, 262]] 1.0 7yaz Homo sapiens TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 M3K20_HUMAN 7YAWB Q9NYL2 8 299 800.0 IGS:60401 Type1.5_Front Inactive DFGin 6.0615 12.8867 BLAplus -112.26, 159.46 66.47, 30.72 -77.06, -4.03 46.81, 82.8 -112.18, 3.53 out-out out 16.1976 Saltbr-out 14.385 HRD-in -68.93, -58.68 76.93, -11.19 out-out-out SNCooo out-out ActLoopNT-out 5.8412 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -56.67, -41.74 APE9-dihe-na -72.55, 0.42 APE8-dihe-out -131.57, -4.4 APE8-rot-out 77.42 APE67-dihe-in -62.57, -21.79 -53.81, -31.98 APE12-dist-out 14.667 APE11-dist-out 14.0274 APE10-dist-out 18.4933 APE9-dist-out 12.4597 None None None XRAY 2.1 0.208 0.243 B 310.0 291.0 1 26 25 1 [[16, 262]] 1.0 7yaw Homo sapiens TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
MAP3K20 M3K20_HUMAN 7YAWC Q9NYL2 8 299 800.0 IGS:60401 Type1.5_Front Inactive DFGin 5.6767 12.9838 BLAplus -105.78, 161.9 66.78, 23.82 -68.46, -14.89 48.8, 88.46 -104.69, -15.53 out-out out 16.0889 Saltbr-out 16.0954 HRD-in -71.18, -58.92 73.09, -4.85 out-out-out SNCooo out-out ActLoopNT-out 5.6164 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -67.62, -51.34 APE9-dihe-na -86.7, 18.29 APE8-dihe-out -115.5, -10.48 APE8-rot-in 308.5 APE67-dihe-in -59.14, -22.29 -53.59, -37.71 APE12-dist-out 14.9863 APE11-dist-in 13.9487 APE10-dist-out 18.3728 APE9-dist-out 12.3026 None None None XRAY 2.1 0.208 0.243 C 310.0 291.0 1 26 25 1 [[16, 262]] 1.0 7yaw Homo sapiens TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2.0 266.0 265.0 150 151 152 154 156 45 53 57 130 132 131 133.0 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20

TKL_MAP3K20 (Mitogen-activated protein kinase kinase kinase 20)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name