STE_MAP2K6 (Dual specificity mitogen-activated protein kinase kinase 6)

Total number of chains: 15
Active chains: 2
Uniprot: MP2K6_HUMAN
Kinase Domain Residues: 53 - 314
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 6 40.0% 8P7JB
DFGin None 4 26.7% 3ENMA
DFGin BLAminus 3 20.0% AF-P52564-K1A
None None 2 13.3% 3VN9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P52564-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 45 - 322 0 None None Dual specificity mitogen-activated protein kinase kinase 6
AF-P52564-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 45 - 322 0 None None Dual specificity mitogen-activated protein kinase kinase 6
3ENMA 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 46 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
3ENMB 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 49 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
3ENMC 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 48 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
3ENMD 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 45 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
8P7JA 2.4 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn X3K Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
8P7JB 2.4 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn X3K Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
8PM3A 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
8PM3B 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
8PM3C 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
8PM3D 2.0 Inactive DFGout‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
3FMEA 2.26 Inactive None‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno STU Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
3VN9A 2.6 Inactive None‑None out-na out-out nonTYR APEdihe_aaiao APEdist_oooo ANK Type1 44 - 334 0 None None Dual specificity mitogen-activated protein kinase kinase 6
8A8MB 4.0 None DFGin‑BLAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn AP2 Type1 38 - 334 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6

STE_MAP2K6 (Dual specificity mitogen-activated protein kinase kinase 6)

Total number of chains: 15
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 6 40.0% 8P7JB
DFGin None 4 26.7% 3ENMA
DFGin BLAminus 3 20.0% AF-P52564-K1A
None None 2 13.3% 3VN9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
MP2K6_HUMAN AF-P52564-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 45 - 322 0 None None Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
MP2K6_HUMAN AF-P52564-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 45 - 322 0 None None Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
MP2K6_HUMAN 3ENMA 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 46 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
MP2K6_HUMAN 3ENMB 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 49 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
MP2K6_HUMAN 3ENMC 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 48 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
MP2K6_HUMAN 3ENMD 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 45 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
MP2K6_HUMAN 8P7JA 2.4 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn X3K Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
MP2K6_HUMAN 8P7JB 2.4 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn X3K Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
MP2K6_HUMAN 8PM3A 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
MP2K6_HUMAN 8PM3B 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
MP2K6_HUMAN 8PM3C 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
MP2K6_HUMAN 8PM3D 2.0 Inactive DFGout‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
MP2K6_HUMAN 3FMEA 2.26 Inactive None‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno STU Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
MP2K6_HUMAN 3VN9A 2.6 Inactive None‑None out-na out-out nonTYR APEdihe_aaiao APEdist_oooo ANK Type1 44 - 334 0 None None Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
MP2K6_HUMAN 8A8MB 4.0 None DFGin‑BLAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn AP2 Type1 38 - 334 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens

STE_MAP2K6 (Dual specificity mitogen-activated protein kinase kinase 6)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism