STE_MAP2K6 (Dual specificity mitogen-activated protein kinase kinase 6)

Total number of chains: 15
Active chains: 2
Uniprot: MP2K6_HUMAN
Kinase Domain Residues: 53 - 314
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 6 40.0% 8P7JB
DFGin None 4 26.7% 3ENMA
DFGin BLAminus 3 20.0% AF-P52564-K1A
None None 2 13.3% 3VN9A

Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP2K6 AF-P52564-K1A P52564 45 322 334.0 No_ligand No_ligand Active DFGin 5.9048 13.4996 BLAminus -145.69, 178.96 61.44, 66.89 -85.87, 11.44 309.77, 111.48 -67.09, -18.76 in-na in 7.589 Saltbr-na 2.667 HRD-in -74.85, -45.86 69.56, -2.68 na-in-in SNCaii in-in ActLoopNT-in 2.8851 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -76.95, 150.78 APE9-dihe-na 93.16, 167.58 APE8-dihe-in -77.2, 117.73 APE8-rot-na 197.0 APE67-dihe-in -66.97, -22.1 -48.05, -44.63 APE12-dist-in 12.7751 APE11-dist-in 10.3843 APE10-dist-in 5.3987 APE9-dist-in 3.4485 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 27 27 0 [[53, 314]] 1.0 AF-P52564-K1 STE_MAP2K6_HUMAN STE 2.3e-85 292.0 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 AF-P52564-K3A P52564 45 322 334.0 No_ligand No_ligand Active DFGin 5.626 13.5004 BLAminus -148.45, -176.54 62.42, 65.82 -84.37, 5.85 308.37, 109.48 -62.57, -20.53 in-na in 8.1127 Saltbr-na 2.697 HRD-in -76.25, -41.87 69.23, -6.15 na-in-in SNCaii in-in ActLoopNT-in 2.8793 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -123.41, 140.98 APE9-dihe-na 110.2, 162.45 APE8-dihe-in -76.59, 111.53 APE8-rot-na 194.17 APE67-dihe-in -66.13, -23.13 -42.41, -45.83 APE12-dist-in 12.7696 APE11-dist-in 10.7611 APE10-dist-in 5.4497 APE9-dist-in 3.444 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 27 27 0 [[53, 314]] 1.0 AF-P52564-K3 STE_MAP2K6_HUMAN STE 2.3e-85 292.0 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 3ENMA P52564 46 332 334.0 No_ligand No_ligand Inactive DFGin 7.2057 11.561 None -72.54, 127.3 -73.54, -5.06 -145.36, 172.63 75.39, 93.79 -81.87, 71.68 out-na out 14.7786 Saltbr-na 19.7289 HRD-in -62.52, -52.47 78.76, -8.63 na-out-none SNCaon out-none ActLoopNT-out 14.8184 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.11, 104.97 999.0, -79.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 A 316.0 278.0 9 27 18 9 [[53, 314]] 1.0 3enm STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 3ENMB P52564 49 332 334.0 No_ligand No_ligand Inactive DFGin 6.4336 11.873 None -76.15, 120.81 -66.53, 1.54 -153.84, 168.39 61.21, 99.4 -71.06, 67.13 out-na out 15.0002 Saltbr-na 20.0247 HRD-in -64.57, -50.97 79.15, -4.28 na-out-none SNCaon out-none ActLoopNT-out 14.4809 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -73.08, 113.2 999.0, -108.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 B 316.0 271.0 13 27 19 8 [[53, 314]] 1.0 3enm STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 3ENMC P52564 48 332 334.0 No_ligand No_ligand Inactive DFGin 6.8007 11.7267 None -62.87, 122.88 -68.86, -8.42 -137.51, 177.55 64.57, 100.37 -78.87, 64.07 out-na out 14.8261 Saltbr-na 19.8254 HRD-in -65.29, -57.18 66.82, -2.67 na-out-none SNCaon out-none ActLoopNT-out 14.5147 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -82.6, 107.52 999.0, -65.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 C 316.0 274.0 11 27 19 8 [[53, 314]] 1.0 3enm STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 3ENMD P52564 45 332 334.0 No_ligand No_ligand Inactive DFGin 6.8746 11.4777 None -70.65, 125.17 -79.65, 11.99 -158.34, 166.38 66.09, 89.82 -77.06, 78.99 out-na out 14.5686 Saltbr-na 19.5439 HRD-in -56.29, -53.91 80.33, -16.21 na-out-none SNCaon out-none ActLoopNT-out 14.8567 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -80.61, 127.32 999.0, -136.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 D 316.0 279.0 9 27 18 9 [[53, 314]] 1.0 3enm STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 8P7JA P52564 47 333 334.0 X3K:60401 Type1 Inactive DFGout 14.2515 11.0019 None -65.47, 133.28 -55.04, -28.77 -68.1, 109.13 186.73, 64.49 73.42, 16.91 in-na in 9.9111 Saltbr-na 6.9537 HRD-in -77.01, -53.31 75.23, 1.98 na-out-none SNCaon out-none ActLoopNT-out 3.9292 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -79.78, 109.02 999.0, 136.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None None XRAY 2.4 0.199 0.257 A 290.0 275.0 12 27 15 12 [[53, 314]] 1.0 8p7j STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 8P7JB P52564 47 333 334.0 X3K:60401 Type1 Inactive DFGout 14.0208 11.6035 None -58.28, 150.55 -77.29, -24.28 -63.25, 115.38 177.02, 74.78 81.07, 7.57 out-na out 10.0296 Saltbr-na 7.317 HRD-in -68.22, -47.82 72.99, -5.32 na-out-out SNCaoo out-out ActLoopNT-out 3.8583 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -64.67 APE8-rot-na 294.32 APE67-dihe-out -87.52, 113.07 -119.25, 94.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None None XRAY 2.4 0.199 0.257 B 290.0 277.0 10 27 17 10 [[53, 314]] 1.0 8p7j STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 8PM3A P52564 47 333 334.0 ZLE:401 Type1 Inactive DFGout 14.1398 10.9916 None -68.3, 148.34 -70.26, -27.95 -68.28, 111.48 188.26, 59.11 78.14, 13.99 out-na out 10.4402 Saltbr-na 6.2009 HRD-in -65.03, -48.31 73.37, 6.37 na-out-out SNCaoo out-out ActLoopNT-out 4.3115 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 106.98 APE8-rot-na 300.68 APE67-dihe-out -80.2, 110.27 -83.05, 148.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None None XRAY 2.0 0.198 0.236 A 290.0 272.0 15 27 17 10 [[53, 314]] 1.0 8pm3 STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 8PM3B P52564 47 333 334.0 ZLE:401 Type1 Inactive DFGout 14.1566 11.0488 None -64.72, 147.85 -67.53, -30.45 -67.44, 111.27 186.22, 62.58 78.46, 12.48 out-na out 10.3747 Saltbr-na 6.2311 HRD-in -64.24, -48.73 73.1, 5.7 na-out-out SNCaoo out-out ActLoopNT-out 4.4397 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.21 APE8-rot-na 291.95 APE67-dihe-out -78.95, 106.16 -95.43, 146.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None None XRAY 2.0 0.198 0.236 B 290.0 273.0 14 27 17 10 [[53, 314]] 1.0 8pm3 STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 8PM3C P52564 47 333 334.0 ZLE:401 Type1 Inactive DFGout 14.2754 11.1566 None -62.2, 146.28 -67.91, -27.86 -66.6, 110.71 183.17, 60.91 87.44, 10.06 out-na out 10.4122 Saltbr-na 6.331 HRD-in -66.26, -50.08 72.66, 3.15 na-out-out SNCaoo out-out ActLoopNT-out 4.0833 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 120.53 APE8-rot-na 271.83 APE67-dihe-out -80.13, 108.4 -78.51, 153.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None None XRAY 2.0 0.198 0.236 C 290.0 273.0 14 27 16 11 [[53, 314]] 1.0 8pm3 STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 8PM3D P52564 47 333 334.0 ZLE:401 Type1 Inactive DFGout 14.2679 11.1656 None -66.56, 150.07 -72.87, -25.62 -66.14, 111.24 184.83, 57.72 85.28, 12.19 out-na out 10.4505 Saltbr-na 6.2874 HRD-in -68.52, -48.22 72.4, 4.18 na-out-none SNCaon out-none ActLoopNT-out 4.0868 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -79.51, 109.87 999.0, 135.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None None XRAY 2.0 0.198 0.236 D 290.0 272.0 15 27 16 11 [[53, 314]] 1.0 8pm3 STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 3FMEA P52564 47 333 334.0 STU:60001 Type1 Inactive None 999.0 999.0 None -108.01, 128.57 -82.08, 37.27 -74.9, 999.0 999.0, 999.0 999.0, 999.0 out-na out 16.0922 Saltbr-na 15.2311 HRD-in -57.54, -47.19 80.18, -0.06 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_nnno APE10-dihe-na 999.0, 108.95 APE9-dihe-na -76.08, 66.3 APE8-dihe-in -91.33, 156.42 APE8-rot-na 298.81 APE67-dihe-out -82.0, 103.94 -93.42, 147.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.9762 S207D,T211D None None XRAY 2.26 0.213 0.236 A 290.0 267.0 20 27 12 15 [[53, 314]] 1.0 3fme STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 3VN9A P52564 44 334 334.0 ANK:401 Type1 Inactive None 12.4842 16.4516 None -156.07, 167.47 49.05, 65.77 -66.48, -73.12 247.27, 104.01 -116.78, -30.67 out-na out 18.407 Saltbr-na 19.799 HRD-out -85.58, 116.13 -89.6, 160.1 na-out-out SNCaoo out-out ActLoopNT-out 8.0413 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_oooo APE10-dihe-na -100.99, -122.29 APE9-dihe-na -158.81, 34.69 APE8-dihe-in -69.41, 135.75 APE8-rot-na 308.2 APE67-dihe-out -83.72, 102.27 -50.21, 136.86 APE12-dist-out 19.8565 APE11-dist-out 17.0364 APE10-dist-out 16.6528 APE9-dist-out 16.9042 None None None XRAY 2.6 0.265 0.28 A 340.0 291.0 0 27 27 0 [[53, 314]] 1.0 3vn9 STE_MAP2K6_HUMAN STE 4.8e-85 291.0 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 8A8MB P52564 38 334 334.0 AP2:60401 Type1 None DFGin 5.4863 11.6397 BLAminus -146.69, -172.97 54.53, 63.91 -81.56, 13.5 331.49, 114.43 -66.25, -37.97 in-na in 8.6147 Saltbr-na 5.512 HRD-in -64.64, -38.02 67.87, -2.84 na-in-none SNCain in-none ActLoopNT-in 3.1849 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -48.81 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None None EM 4.0 999.0 999.0 B 374.0 284.0 13 27 14 13 [[53, 314]] 1.0 8a8m STE_MAP2K6_HUMAN STE 8.9e-85 290.1 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6

STE_MAP2K6 (Dual specificity mitogen-activated protein kinase kinase 6)

Total number of chains: 15
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 6 40.0% 8P7JB
DFGin None 4 26.7% 3ENMA
DFGin BLAminus 3 20.0% AF-P52564-K1A
None None 2 13.3% 3VN9A

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP2K6 MP2K6_HUMAN AF-P52564-K1A P52564 45 322 334.0 No_ligand No_ligand Active DFGin 5.9048 13.4996 BLAminus -145.69, 178.96 61.44, 66.89 -85.87, 11.44 309.77, 111.48 -67.09, -18.76 in-na in 7.589 Saltbr-na 2.667 HRD-in -74.85, -45.86 69.56, -2.68 na-in-in SNCaii in-in ActLoopNT-in 2.8851 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -76.95, 150.78 APE9-dihe-na 93.16, 167.58 APE8-dihe-in -77.2, 117.73 APE8-rot-na 197.0 APE67-dihe-in -66.97, -22.1 -48.05, -44.63 APE12-dist-in 12.7751 APE11-dist-in 10.3843 APE10-dist-in 5.3987 APE9-dist-in 3.4485 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 27 27 0 [[53, 314]] 1.0 AF-P52564-K1 Homo sapiens STE_MAP2K6_HUMAN STE 2.3e-85 292.0 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 MP2K6_HUMAN AF-P52564-K3A P52564 45 322 334.0 No_ligand No_ligand Active DFGin 5.626 13.5004 BLAminus -148.45, -176.54 62.42, 65.82 -84.37, 5.85 308.37, 109.48 -62.57, -20.53 in-na in 8.1127 Saltbr-na 2.697 HRD-in -76.25, -41.87 69.23, -6.15 na-in-in SNCaii in-in ActLoopNT-in 2.8793 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -123.41, 140.98 APE9-dihe-na 110.2, 162.45 APE8-dihe-in -76.59, 111.53 APE8-rot-na 194.17 APE67-dihe-in -66.13, -23.13 -42.41, -45.83 APE12-dist-in 12.7696 APE11-dist-in 10.7611 APE10-dist-in 5.4497 APE9-dist-in 3.444 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 27 27 0 [[53, 314]] 1.0 AF-P52564-K3 Homo sapiens STE_MAP2K6_HUMAN STE 2.3e-85 292.0 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 MP2K6_HUMAN 3ENMA P52564 46 332 334.0 No_ligand No_ligand Inactive DFGin 7.2057 11.561 None -72.54, 127.3 -73.54, -5.06 -145.36, 172.63 75.39, 93.79 -81.87, 71.68 out-na out 14.7786 Saltbr-na 19.7289 HRD-in -62.52, -52.47 78.76, -8.63 na-out-none SNCaon out-none ActLoopNT-out 14.8184 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.11, 104.97 999.0, -79.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 A 316.0 278.0 9 27 18 9 [[53, 314]] 1.0 3enm Homo sapiens STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 MP2K6_HUMAN 3ENMB P52564 49 332 334.0 No_ligand No_ligand Inactive DFGin 6.4336 11.873 None -76.15, 120.81 -66.53, 1.54 -153.84, 168.39 61.21, 99.4 -71.06, 67.13 out-na out 15.0002 Saltbr-na 20.0247 HRD-in -64.57, -50.97 79.15, -4.28 na-out-none SNCaon out-none ActLoopNT-out 14.4809 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -73.08, 113.2 999.0, -108.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 B 316.0 271.0 13 27 19 8 [[53, 314]] 1.0 3enm Homo sapiens STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 MP2K6_HUMAN 3ENMC P52564 48 332 334.0 No_ligand No_ligand Inactive DFGin 6.8007 11.7267 None -62.87, 122.88 -68.86, -8.42 -137.51, 177.55 64.57, 100.37 -78.87, 64.07 out-na out 14.8261 Saltbr-na 19.8254 HRD-in -65.29, -57.18 66.82, -2.67 na-out-none SNCaon out-none ActLoopNT-out 14.5147 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -82.6, 107.52 999.0, -65.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 C 316.0 274.0 11 27 19 8 [[53, 314]] 1.0 3enm Homo sapiens STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 MP2K6_HUMAN 3ENMD P52564 45 332 334.0 No_ligand No_ligand Inactive DFGin 6.8746 11.4777 None -70.65, 125.17 -79.65, 11.99 -158.34, 166.38 66.09, 89.82 -77.06, 78.99 out-na out 14.5686 Saltbr-na 19.5439 HRD-in -56.29, -53.91 80.33, -16.21 na-out-none SNCaon out-none ActLoopNT-out 14.8567 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -80.61, 127.32 999.0, -136.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 D 316.0 279.0 9 27 18 9 [[53, 314]] 1.0 3enm Homo sapiens STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 MP2K6_HUMAN 8P7JA P52564 47 333 334.0 X3K:60401 Type1 Inactive DFGout 14.2515 11.0019 None -65.47, 133.28 -55.04, -28.77 -68.1, 109.13 186.73, 64.49 73.42, 16.91 in-na in 9.9111 Saltbr-na 6.9537 HRD-in -77.01, -53.31 75.23, 1.98 na-out-none SNCaon out-none ActLoopNT-out 3.9292 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -79.78, 109.02 999.0, 136.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None None XRAY 2.4 0.199 0.257 A 290.0 275.0 12 27 15 12 [[53, 314]] 1.0 8p7j Homo sapiens STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 MP2K6_HUMAN 8P7JB P52564 47 333 334.0 X3K:60401 Type1 Inactive DFGout 14.0208 11.6035 None -58.28, 150.55 -77.29, -24.28 -63.25, 115.38 177.02, 74.78 81.07, 7.57 out-na out 10.0296 Saltbr-na 7.317 HRD-in -68.22, -47.82 72.99, -5.32 na-out-out SNCaoo out-out ActLoopNT-out 3.8583 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -64.67 APE8-rot-na 294.32 APE67-dihe-out -87.52, 113.07 -119.25, 94.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None None XRAY 2.4 0.199 0.257 B 290.0 277.0 10 27 17 10 [[53, 314]] 1.0 8p7j Homo sapiens STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 MP2K6_HUMAN 8PM3A P52564 47 333 334.0 ZLE:401 Type1 Inactive DFGout 14.1398 10.9916 None -68.3, 148.34 -70.26, -27.95 -68.28, 111.48 188.26, 59.11 78.14, 13.99 out-na out 10.4402 Saltbr-na 6.2009 HRD-in -65.03, -48.31 73.37, 6.37 na-out-out SNCaoo out-out ActLoopNT-out 4.3115 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 106.98 APE8-rot-na 300.68 APE67-dihe-out -80.2, 110.27 -83.05, 148.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None None XRAY 2.0 0.198 0.236 A 290.0 272.0 15 27 17 10 [[53, 314]] 1.0 8pm3 Homo sapiens STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 MP2K6_HUMAN 8PM3B P52564 47 333 334.0 ZLE:401 Type1 Inactive DFGout 14.1566 11.0488 None -64.72, 147.85 -67.53, -30.45 -67.44, 111.27 186.22, 62.58 78.46, 12.48 out-na out 10.3747 Saltbr-na 6.2311 HRD-in -64.24, -48.73 73.1, 5.7 na-out-out SNCaoo out-out ActLoopNT-out 4.4397 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.21 APE8-rot-na 291.95 APE67-dihe-out -78.95, 106.16 -95.43, 146.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None None XRAY 2.0 0.198 0.236 B 290.0 273.0 14 27 17 10 [[53, 314]] 1.0 8pm3 Homo sapiens STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 MP2K6_HUMAN 8PM3C P52564 47 333 334.0 ZLE:401 Type1 Inactive DFGout 14.2754 11.1566 None -62.2, 146.28 -67.91, -27.86 -66.6, 110.71 183.17, 60.91 87.44, 10.06 out-na out 10.4122 Saltbr-na 6.331 HRD-in -66.26, -50.08 72.66, 3.15 na-out-out SNCaoo out-out ActLoopNT-out 4.0833 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 120.53 APE8-rot-na 271.83 APE67-dihe-out -80.13, 108.4 -78.51, 153.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None None XRAY 2.0 0.198 0.236 C 290.0 273.0 14 27 16 11 [[53, 314]] 1.0 8pm3 Homo sapiens STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 MP2K6_HUMAN 8PM3D P52564 47 333 334.0 ZLE:401 Type1 Inactive DFGout 14.2679 11.1656 None -66.56, 150.07 -72.87, -25.62 -66.14, 111.24 184.83, 57.72 85.28, 12.19 out-na out 10.4505 Saltbr-na 6.2874 HRD-in -68.52, -48.22 72.4, 4.18 na-out-none SNCaon out-none ActLoopNT-out 4.0868 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -79.51, 109.87 999.0, 135.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None None XRAY 2.0 0.198 0.236 D 290.0 272.0 15 27 16 11 [[53, 314]] 1.0 8pm3 Homo sapiens STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 MP2K6_HUMAN 3FMEA P52564 47 333 334.0 STU:60001 Type1 Inactive None 999.0 999.0 None -108.01, 128.57 -82.08, 37.27 -74.9, 999.0 999.0, 999.0 999.0, 999.0 out-na out 16.0922 Saltbr-na 15.2311 HRD-in -57.54, -47.19 80.18, -0.06 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_nnno APE10-dihe-na 999.0, 108.95 APE9-dihe-na -76.08, 66.3 APE8-dihe-in -91.33, 156.42 APE8-rot-na 298.81 APE67-dihe-out -82.0, 103.94 -93.42, 147.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.9762 S207D,T211D None None XRAY 2.26 0.213 0.236 A 290.0 267.0 20 27 12 15 [[53, 314]] 1.0 3fme Homo sapiens STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 MP2K6_HUMAN 3VN9A P52564 44 334 334.0 ANK:401 Type1 Inactive None 12.4842 16.4516 None -156.07, 167.47 49.05, 65.77 -66.48, -73.12 247.27, 104.01 -116.78, -30.67 out-na out 18.407 Saltbr-na 19.799 HRD-out -85.58, 116.13 -89.6, 160.1 na-out-out SNCaoo out-out ActLoopNT-out 8.0413 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_oooo APE10-dihe-na -100.99, -122.29 APE9-dihe-na -158.81, 34.69 APE8-dihe-in -69.41, 135.75 APE8-rot-na 308.2 APE67-dihe-out -83.72, 102.27 -50.21, 136.86 APE12-dist-out 19.8565 APE11-dist-out 17.0364 APE10-dist-out 16.6528 APE9-dist-out 16.9042 None None None XRAY 2.6 0.265 0.28 A 340.0 291.0 0 27 27 0 [[53, 314]] 1.0 3vn9 Homo sapiens STE_MAP2K6_HUMAN STE 4.8e-85 291.0 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
MAP2K6 MP2K6_HUMAN 8A8MB P52564 38 334 334.0 AP2:60401 Type1 None DFGin 5.4863 11.6397 BLAminus -146.69, -172.97 54.53, 63.91 -81.56, 13.5 331.49, 114.43 -66.25, -37.97 in-na in 8.6147 Saltbr-na 5.512 HRD-in -64.64, -38.02 67.87, -2.84 na-in-none SNCain in-none ActLoopNT-in 3.1849 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -48.81 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None None EM 4.0 999.0 999.0 B 374.0 284.0 13 27 14 13 [[53, 314]] 1.0 8a8m Homo sapiens STE_MAP2K6_HUMAN STE 8.9e-85 290.1 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6

STE_MAP2K6 (Dual specificity mitogen-activated protein kinase kinase 6)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name