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| PDB | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AF-P52564-K1A | 45 | 322 | 334.0 | No_ligand | No_ligand | Active | DFGin | 5.905 | 13.5 | BLAminus | -145.69, 178.96 | 61.44, 66.89 | -85.87, 11.44 | 309.77, 111.48 | -67.09, -18.76 | na-na | na | 7.589 | Saltbr-na | 2.667 | HRD-in | -74.85, -45.86 | 69.56, -2.68 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.885 | ActLoopCT-in | nonTYR | APEdihe_aaiai | APEdist_iiii | APE10-dihe-na | -76.95, 150.78 | APE9-dihe-na | 93.16, 167.58 | APE8-dihe-in | -77.2, 117.73 | APE8-rot-na | 197.0 | APE67-dihe-in | -66.97, -22.1 | -48.05, -44.63 | APE12-dist-in | 12.775 | APE11-dist-in | 10.384 | APE10-dist-in | 5.399 | APE9-dist-in | 3.449 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 278 | 278 | 0 | 0 | 0 | 0 | [[53, 314]] | 1.0 | AF-P52564-K1 | STE_MAP2K6_HUMAN | STE | 2.3e-85 | 292.0 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| AF-P52564-K3A | 45 | 322 | 334.0 | No_ligand | No_ligand | Active | DFGin | 5.626 | 13.5 | BLAminus | -148.45, -176.54 | 62.42, 65.82 | -84.37, 5.85 | 308.37, 109.48 | -62.57, -20.53 | na-na | na | 8.113 | Saltbr-na | 2.697 | HRD-in | -76.25, -41.87 | 69.23, -6.15 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.879 | ActLoopCT-in | nonTYR | APEdihe_aaiai | APEdist_iiii | APE10-dihe-na | -123.41, 140.98 | APE9-dihe-na | 110.2, 162.45 | APE8-dihe-in | -76.59, 111.53 | APE8-rot-na | 194.17 | APE67-dihe-in | -66.13, -23.13 | -42.41, -45.83 | APE12-dist-in | 12.77 | APE11-dist-in | 10.761 | APE10-dist-in | 5.45 | APE9-dist-in | 3.444 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 278 | 278 | 0 | 0 | 0 | 0 | [[53, 314]] | 1.0 | AF-P52564-K3 | STE_MAP2K6_HUMAN | STE | 2.3e-85 | 292.0 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| 3ENMA | 46 | 332 | 334.0 | No_ligand | No_ligand | Inactive | DFGin | 7.206 | 11.561 | None | -72.54, 127.3 | -73.54, -5.06 | -145.36, 172.63 | 75.39, 93.79 | -81.87, 71.68 | na-na | na | 14.779 | Saltbr-na | 19.729 | HRD-in | -62.52, -52.47 | 78.76, -8.63 | na-out-none | SNCaon | out-none | ActLoopNT-out | 14.818 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -69.11, 104.97 | 999.0, -79.37 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 | XRAY | 2.35 | 0.215 | 0.269 | A | 316 | 278 | 9 | 0 | 0 | 9 | [[53, 314]] | 1.0 | 3enm | STE_MAP2K6_HUMAN | STE | 5.1e-85 | 290.9 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| 3ENMB | 49 | 332 | 334.0 | No_ligand | No_ligand | Inactive | DFGin | 6.434 | 11.873 | None | -76.15, 120.81 | -66.53, 1.54 | -153.84, 168.39 | 61.21, 99.4 | -71.06, 67.13 | na-na | na | 15.0 | Saltbr-na | 20.025 | HRD-in | -64.57, -50.97 | 79.15, -4.28 | na-out-none | SNCaon | out-none | ActLoopNT-out | 14.481 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -73.08, 113.2 | 999.0, -108.84 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 | XRAY | 2.35 | 0.215 | 0.269 | B | 316 | 271 | 13 | 0 | 0 | 8 | [[53, 314]] | 1.0 | 3enm | STE_MAP2K6_HUMAN | STE | 5.1e-85 | 290.9 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| 3ENMC | 48 | 332 | 334.0 | No_ligand | No_ligand | Inactive | DFGin | 6.801 | 11.727 | None | -62.87, 122.88 | -68.86, -8.42 | -137.51, 177.55 | 64.57, 100.37 | -78.87, 64.07 | na-na | na | 14.826 | Saltbr-na | 19.825 | HRD-in | -65.29, -57.18 | 66.82, -2.67 | na-out-none | SNCaon | out-none | ActLoopNT-out | 14.515 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -82.6, 107.52 | 999.0, -65.96 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 | XRAY | 2.35 | 0.215 | 0.269 | C | 316 | 274 | 11 | 0 | 0 | 8 | [[53, 314]] | 1.0 | 3enm | STE_MAP2K6_HUMAN | STE | 5.1e-85 | 290.9 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| 3ENMD | 45 | 332 | 334.0 | No_ligand | No_ligand | Inactive | DFGin | 6.875 | 11.478 | None | -70.65, 125.17 | -79.65, 11.99 | -158.34, 166.38 | 66.09, 89.82 | -77.06, 78.99 | na-na | na | 14.569 | Saltbr-na | 19.544 | HRD-in | -56.29, -53.91 | 80.33, -16.21 | na-out-none | SNCaon | out-none | ActLoopNT-out | 14.857 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -80.61, 127.32 | 999.0, -136.25 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 | XRAY | 2.35 | 0.215 | 0.269 | D | 316 | 279 | 9 | 0 | 0 | 9 | [[53, 314]] | 1.0 | 3enm | STE_MAP2K6_HUMAN | STE | 5.1e-85 | 290.9 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| 8P7JA | 47 | 333 | 334.0 | X3K:60401 | Type1 | Inactive | DFGout | 14.252 | 11.002 | None | -65.47, 133.28 | -55.04, -28.77 | -68.1, 109.13 | 186.73, 64.49 | 73.42, 16.91 | na-na | na | 9.911 | Saltbr-na | 6.954 | HRD-in | -77.01, -53.31 | 75.23, 1.98 | na-out-none | SNCaon | out-none | ActLoopNT-out | 3.929 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -79.78, 109.02 | 999.0, 136.8 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | None | XRAY | 2.4 | 0.199 | 0.257 | A | 290 | 275 | 12 | 0 | 0 | 12 | [[53, 314]] | 1.0 | 8p7j | STE_MAP2K6_HUMAN | STE | 3.8e-85 | 291.3 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| 8P7JB | 47 | 333 | 334.0 | X3K:60401 | Type1 | Inactive | DFGout | 14.021 | 11.604 | None | -58.28, 150.55 | -77.29, -24.28 | -63.25, 115.38 | 177.02, 74.78 | 81.07, 7.57 | na-na | na | 10.03 | Saltbr-na | 7.317 | HRD-in | -68.22, -47.82 | 72.99, -5.32 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 3.858 | ActLoopCT-out | nonTYR | APEdihe_aanao | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, -64.67 | APE8-rot-na | 294.32 | APE67-dihe-out | -87.52, 113.07 | -119.25, 94.44 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | None | XRAY | 2.4 | 0.199 | 0.257 | B | 290 | 277 | 10 | 0 | 0 | 10 | [[53, 314]] | 1.0 | 8p7j | STE_MAP2K6_HUMAN | STE | 3.8e-85 | 291.3 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| 8PM3A | 47 | 333 | 334.0 | ZLE:401 | Type1 | Inactive | DFGout | 14.14 | 10.992 | None | -68.3, 148.34 | -70.26, -27.95 | -68.28, 111.48 | 188.26, 59.11 | 78.14, 13.99 | na-na | na | 10.44 | Saltbr-na | 6.201 | HRD-in | -65.03, -48.31 | 73.37, 6.37 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 4.311 | ActLoopCT-out | nonTYR | APEdihe_aanao | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 106.98 | APE8-rot-na | 300.68 | APE67-dihe-out | -80.2, 110.27 | -83.05, 148.16 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | None | XRAY | 2.0 | 0.198 | 0.236 | A | 290 | 272 | 15 | 0 | 0 | 10 | [[53, 314]] | 1.0 | 8pm3 | STE_MAP2K6_HUMAN | STE | 3.8e-85 | 291.3 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| 8PM3B | 47 | 333 | 334.0 | ZLE:401 | Type1 | Inactive | DFGout | 14.157 | 11.049 | None | -64.72, 147.85 | -67.53, -30.45 | -67.44, 111.27 | 186.22, 62.58 | 78.46, 12.48 | na-na | na | 10.375 | Saltbr-na | 6.231 | HRD-in | -64.24, -48.73 | 73.1, 5.7 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 4.44 | ActLoopCT-out | nonTYR | APEdihe_aanao | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 128.21 | APE8-rot-na | 291.95 | APE67-dihe-out | -78.95, 106.16 | -95.43, 146.79 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | None | XRAY | 2.0 | 0.198 | 0.236 | B | 290 | 273 | 14 | 0 | 0 | 10 | [[53, 314]] | 1.0 | 8pm3 | STE_MAP2K6_HUMAN | STE | 3.8e-85 | 291.3 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| 8PM3C | 47 | 333 | 334.0 | ZLE:401 | Type1 | Inactive | DFGout | 14.275 | 11.157 | None | -62.2, 146.28 | -67.91, -27.86 | -66.6, 110.71 | 183.17, 60.91 | 87.44, 10.06 | na-na | na | 10.412 | Saltbr-na | 6.331 | HRD-in | -66.26, -50.08 | 72.66, 3.15 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 4.083 | ActLoopCT-out | nonTYR | APEdihe_aanao | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 120.53 | APE8-rot-na | 271.83 | APE67-dihe-out | -80.13, 108.4 | -78.51, 153.18 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | None | XRAY | 2.0 | 0.198 | 0.236 | C | 290 | 273 | 14 | 0 | 0 | 11 | [[53, 314]] | 1.0 | 8pm3 | STE_MAP2K6_HUMAN | STE | 3.8e-85 | 291.3 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| 8PM3D | 47 | 333 | 334.0 | ZLE:401 | Type1 | Inactive | DFGout | 14.268 | 11.166 | None | -66.56, 150.07 | -72.87, -25.62 | -66.14, 111.24 | 184.83, 57.72 | 85.28, 12.19 | na-na | na | 10.45 | Saltbr-na | 6.287 | HRD-in | -68.52, -48.22 | 72.4, 4.18 | na-out-none | SNCaon | out-none | ActLoopNT-out | 4.087 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -79.51, 109.87 | 999.0, 135.8 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | None | XRAY | 2.0 | 0.198 | 0.236 | D | 290 | 272 | 15 | 0 | 0 | 11 | [[53, 314]] | 1.0 | 8pm3 | STE_MAP2K6_HUMAN | STE | 3.8e-85 | 291.3 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| 3FMEA | 47 | 333 | 334.0 | STU:60001 | Type1 | Inactive | None | 999.0 | 999.0 | None | -108.01, 128.57 | -82.08, 37.27 | -74.9, 999.0 | 999.0, 999.0 | 999.0, 999.0 | na-na | na | 16.092 | Saltbr-na | 15.231 | HRD-in | -57.54, -47.19 | 80.18, -0.06 | na-none-out | SNCano | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | nonTYR | APEdihe_aaiao | APEdist_nnno | APE10-dihe-na | 999.0, 108.95 | APE9-dihe-na | -76.08, 66.3 | APE8-dihe-in | -91.33, 156.42 | APE8-rot-na | 298.81 | APE67-dihe-out | -82.0, 103.94 | -93.42, 147.99 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 16.976 | S207D,T211D | None | None | XRAY | 2.26 | 0.213 | 0.236 | A | 290 | 267 | 20 | 0 | 0 | 15 | [[53, 314]] | 1.0 | 3fme | STE_MAP2K6_HUMAN | STE | 3.8e-85 | 291.3 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| 3VN9A | 44 | 334 | 334.0 | ANK:401 | Type1 | Inactive | None | 12.484 | 16.452 | None | -156.07, 167.47 | 49.05, 65.77 | -66.48, -73.12 | 247.27, 104.01 | -116.78, -30.67 | na-na | na | 18.407 | Saltbr-na | 19.799 | HRD-out | -85.58, 116.13 | -89.6, 160.1 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 8.041 | ActLoopCT-out | nonTYR | APEdihe_aaiao | APEdist_oooo | APE10-dihe-na | -100.99, -122.29 | APE9-dihe-na | -158.81, 34.69 | APE8-dihe-in | -69.41, 135.75 | APE8-rot-na | 308.2 | APE67-dihe-out | -83.72, 102.27 | -50.21, 136.86 | APE12-dist-out | 19.857 | APE11-dist-out | 17.036 | APE10-dist-out | 16.653 | APE9-dist-out | 16.904 | None | None | None | XRAY | 2.6 | 0.265 | 0.28 | A | 340 | 291 | 0 | 0 | 0 | 0 | [[53, 314]] | 1.0 | 3vn9 | STE_MAP2K6_HUMAN | STE | 4.8e-85 | 291.0 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| 8A8MB | 38 | 334 | 334.0 | AP2:60401 | Type1 | None | DFGin | 5.486 | 11.64 | BLAminus | -146.69, -172.97 | 54.53, 63.91 | -81.56, 13.5 | 331.49, 114.43 | -66.25, -37.97 | na-na | na | 8.615 | Saltbr-na | 5.512 | HRD-in | -64.64, -38.02 | 67.87, -2.84 | na-in-none | SNCain | in-none | ActLoopNT-in | 3.185 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | 999.0, -48.81 | 999.0, 999.0 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | None | EM | 4.0 | 999.0 | 999.0 | B | 374 | 284 | 13 | 0 | 0 | 13 | [[53, 314]] | 1.0 | 8a8m | STE_MAP2K6_HUMAN | STE | 8.9e-85 | 290.1 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
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| SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MP2K6_HUMAN | AF-P52564-K1A | P52564 | 45 | 322 | 334.0 | No_ligand | No_ligand | Active | DFGin | 5.905 | 13.5 | BLAminus | -145.69, 178.96 | 61.44, 66.89 | -85.87, 11.44 | 309.77, 111.48 | -67.09, -18.76 | na-na | na | 7.589 | Saltbr-na | 2.667 | HRD-in | -74.85, -45.86 | 69.56, -2.68 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.885 | ActLoopCT-in | nonTYR | APEdihe_aaiai | APEdist_iiii | APE10-dihe-na | -76.95, 150.78 | APE9-dihe-na | 93.16, 167.58 | APE8-dihe-in | -77.2, 117.73 | APE8-rot-na | 197.0 | APE67-dihe-in | -66.97, -22.1 | -48.05, -44.63 | APE12-dist-in | 12.775 | APE11-dist-in | 10.384 | APE10-dist-in | 5.399 | APE9-dist-in | 3.449 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 278 | 278 | 0 | 0 | 0 | 0 | [[53, 314]] | 1.0 | AF-P52564-K1 | Homo sapiens | STE_MAP2K6_HUMAN | STE | 2.3e-85 | 292.0 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| MP2K6_HUMAN | AF-P52564-K3A | P52564 | 45 | 322 | 334.0 | No_ligand | No_ligand | Active | DFGin | 5.626 | 13.5 | BLAminus | -148.45, -176.54 | 62.42, 65.82 | -84.37, 5.85 | 308.37, 109.48 | -62.57, -20.53 | na-na | na | 8.113 | Saltbr-na | 2.697 | HRD-in | -76.25, -41.87 | 69.23, -6.15 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.879 | ActLoopCT-in | nonTYR | APEdihe_aaiai | APEdist_iiii | APE10-dihe-na | -123.41, 140.98 | APE9-dihe-na | 110.2, 162.45 | APE8-dihe-in | -76.59, 111.53 | APE8-rot-na | 194.17 | APE67-dihe-in | -66.13, -23.13 | -42.41, -45.83 | APE12-dist-in | 12.77 | APE11-dist-in | 10.761 | APE10-dist-in | 5.45 | APE9-dist-in | 3.444 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 278 | 278 | 0 | 0 | 0 | 0 | [[53, 314]] | 1.0 | AF-P52564-K3 | Homo sapiens | STE_MAP2K6_HUMAN | STE | 2.3e-85 | 292.0 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| MP2K6_HUMAN | 3ENMA | P52564 | 46 | 332 | 334.0 | No_ligand | No_ligand | Inactive | DFGin | 7.206 | 11.561 | None | -72.54, 127.3 | -73.54, -5.06 | -145.36, 172.63 | 75.39, 93.79 | -81.87, 71.68 | na-na | na | 14.779 | Saltbr-na | 19.729 | HRD-in | -62.52, -52.47 | 78.76, -8.63 | na-out-none | SNCaon | out-none | ActLoopNT-out | 14.818 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -69.11, 104.97 | 999.0, -79.37 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 | XRAY | 2.35 | 0.215 | 0.269 | A | 316 | 278 | 9 | 0 | 0 | 9 | [[53, 314]] | 1.0 | 3enm | Homo sapiens | STE_MAP2K6_HUMAN | STE | 5.1e-85 | 290.9 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| MP2K6_HUMAN | 3ENMB | P52564 | 49 | 332 | 334.0 | No_ligand | No_ligand | Inactive | DFGin | 6.434 | 11.873 | None | -76.15, 120.81 | -66.53, 1.54 | -153.84, 168.39 | 61.21, 99.4 | -71.06, 67.13 | na-na | na | 15.0 | Saltbr-na | 20.025 | HRD-in | -64.57, -50.97 | 79.15, -4.28 | na-out-none | SNCaon | out-none | ActLoopNT-out | 14.481 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -73.08, 113.2 | 999.0, -108.84 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 | XRAY | 2.35 | 0.215 | 0.269 | B | 316 | 271 | 13 | 0 | 0 | 8 | [[53, 314]] | 1.0 | 3enm | Homo sapiens | STE_MAP2K6_HUMAN | STE | 5.1e-85 | 290.9 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| MP2K6_HUMAN | 3ENMC | P52564 | 48 | 332 | 334.0 | No_ligand | No_ligand | Inactive | DFGin | 6.801 | 11.727 | None | -62.87, 122.88 | -68.86, -8.42 | -137.51, 177.55 | 64.57, 100.37 | -78.87, 64.07 | na-na | na | 14.826 | Saltbr-na | 19.825 | HRD-in | -65.29, -57.18 | 66.82, -2.67 | na-out-none | SNCaon | out-none | ActLoopNT-out | 14.515 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -82.6, 107.52 | 999.0, -65.96 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 | XRAY | 2.35 | 0.215 | 0.269 | C | 316 | 274 | 11 | 0 | 0 | 8 | [[53, 314]] | 1.0 | 3enm | Homo sapiens | STE_MAP2K6_HUMAN | STE | 5.1e-85 | 290.9 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| MP2K6_HUMAN | 3ENMD | P52564 | 45 | 332 | 334.0 | No_ligand | No_ligand | Inactive | DFGin | 6.875 | 11.478 | None | -70.65, 125.17 | -79.65, 11.99 | -158.34, 166.38 | 66.09, 89.82 | -77.06, 78.99 | na-na | na | 14.569 | Saltbr-na | 19.544 | HRD-in | -56.29, -53.91 | 80.33, -16.21 | na-out-none | SNCaon | out-none | ActLoopNT-out | 14.857 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -80.61, 127.32 | 999.0, -136.25 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 | XRAY | 2.35 | 0.215 | 0.269 | D | 316 | 279 | 9 | 0 | 0 | 9 | [[53, 314]] | 1.0 | 3enm | Homo sapiens | STE_MAP2K6_HUMAN | STE | 5.1e-85 | 290.9 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| MP2K6_HUMAN | 8P7JA | P52564 | 47 | 333 | 334.0 | X3K:60401 | Type1 | Inactive | DFGout | 14.252 | 11.002 | None | -65.47, 133.28 | -55.04, -28.77 | -68.1, 109.13 | 186.73, 64.49 | 73.42, 16.91 | na-na | na | 9.911 | Saltbr-na | 6.954 | HRD-in | -77.01, -53.31 | 75.23, 1.98 | na-out-none | SNCaon | out-none | ActLoopNT-out | 3.929 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -79.78, 109.02 | 999.0, 136.8 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | None | XRAY | 2.4 | 0.199 | 0.257 | A | 290 | 275 | 12 | 0 | 0 | 12 | [[53, 314]] | 1.0 | 8p7j | Homo sapiens | STE_MAP2K6_HUMAN | STE | 3.8e-85 | 291.3 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| MP2K6_HUMAN | 8P7JB | P52564 | 47 | 333 | 334.0 | X3K:60401 | Type1 | Inactive | DFGout | 14.021 | 11.604 | None | -58.28, 150.55 | -77.29, -24.28 | -63.25, 115.38 | 177.02, 74.78 | 81.07, 7.57 | na-na | na | 10.03 | Saltbr-na | 7.317 | HRD-in | -68.22, -47.82 | 72.99, -5.32 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 3.858 | ActLoopCT-out | nonTYR | APEdihe_aanao | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, -64.67 | APE8-rot-na | 294.32 | APE67-dihe-out | -87.52, 113.07 | -119.25, 94.44 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | None | XRAY | 2.4 | 0.199 | 0.257 | B | 290 | 277 | 10 | 0 | 0 | 10 | [[53, 314]] | 1.0 | 8p7j | Homo sapiens | STE_MAP2K6_HUMAN | STE | 3.8e-85 | 291.3 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| MP2K6_HUMAN | 8PM3A | P52564 | 47 | 333 | 334.0 | ZLE:401 | Type1 | Inactive | DFGout | 14.14 | 10.992 | None | -68.3, 148.34 | -70.26, -27.95 | -68.28, 111.48 | 188.26, 59.11 | 78.14, 13.99 | na-na | na | 10.44 | Saltbr-na | 6.201 | HRD-in | -65.03, -48.31 | 73.37, 6.37 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 4.311 | ActLoopCT-out | nonTYR | APEdihe_aanao | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 106.98 | APE8-rot-na | 300.68 | APE67-dihe-out | -80.2, 110.27 | -83.05, 148.16 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | None | XRAY | 2.0 | 0.198 | 0.236 | A | 290 | 272 | 15 | 0 | 0 | 10 | [[53, 314]] | 1.0 | 8pm3 | Homo sapiens | STE_MAP2K6_HUMAN | STE | 3.8e-85 | 291.3 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| MP2K6_HUMAN | 8PM3B | P52564 | 47 | 333 | 334.0 | ZLE:401 | Type1 | Inactive | DFGout | 14.157 | 11.049 | None | -64.72, 147.85 | -67.53, -30.45 | -67.44, 111.27 | 186.22, 62.58 | 78.46, 12.48 | na-na | na | 10.375 | Saltbr-na | 6.231 | HRD-in | -64.24, -48.73 | 73.1, 5.7 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 4.44 | ActLoopCT-out | nonTYR | APEdihe_aanao | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 128.21 | APE8-rot-na | 291.95 | APE67-dihe-out | -78.95, 106.16 | -95.43, 146.79 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | None | XRAY | 2.0 | 0.198 | 0.236 | B | 290 | 273 | 14 | 0 | 0 | 10 | [[53, 314]] | 1.0 | 8pm3 | Homo sapiens | STE_MAP2K6_HUMAN | STE | 3.8e-85 | 291.3 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| MP2K6_HUMAN | 8PM3C | P52564 | 47 | 333 | 334.0 | ZLE:401 | Type1 | Inactive | DFGout | 14.275 | 11.157 | None | -62.2, 146.28 | -67.91, -27.86 | -66.6, 110.71 | 183.17, 60.91 | 87.44, 10.06 | na-na | na | 10.412 | Saltbr-na | 6.331 | HRD-in | -66.26, -50.08 | 72.66, 3.15 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 4.083 | ActLoopCT-out | nonTYR | APEdihe_aanao | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 120.53 | APE8-rot-na | 271.83 | APE67-dihe-out | -80.13, 108.4 | -78.51, 153.18 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | None | XRAY | 2.0 | 0.198 | 0.236 | C | 290 | 273 | 14 | 0 | 0 | 11 | [[53, 314]] | 1.0 | 8pm3 | Homo sapiens | STE_MAP2K6_HUMAN | STE | 3.8e-85 | 291.3 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| MP2K6_HUMAN | 8PM3D | P52564 | 47 | 333 | 334.0 | ZLE:401 | Type1 | Inactive | DFGout | 14.268 | 11.166 | None | -66.56, 150.07 | -72.87, -25.62 | -66.14, 111.24 | 184.83, 57.72 | 85.28, 12.19 | na-na | na | 10.45 | Saltbr-na | 6.287 | HRD-in | -68.52, -48.22 | 72.4, 4.18 | na-out-none | SNCaon | out-none | ActLoopNT-out | 4.087 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -79.51, 109.87 | 999.0, 135.8 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | None | XRAY | 2.0 | 0.198 | 0.236 | D | 290 | 272 | 15 | 0 | 0 | 11 | [[53, 314]] | 1.0 | 8pm3 | Homo sapiens | STE_MAP2K6_HUMAN | STE | 3.8e-85 | 291.3 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| MP2K6_HUMAN | 3FMEA | P52564 | 47 | 333 | 334.0 | STU:60001 | Type1 | Inactive | None | 999.0 | 999.0 | None | -108.01, 128.57 | -82.08, 37.27 | -74.9, 999.0 | 999.0, 999.0 | 999.0, 999.0 | na-na | na | 16.092 | Saltbr-na | 15.231 | HRD-in | -57.54, -47.19 | 80.18, -0.06 | na-none-out | SNCano | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | nonTYR | APEdihe_aaiao | APEdist_nnno | APE10-dihe-na | 999.0, 108.95 | APE9-dihe-na | -76.08, 66.3 | APE8-dihe-in | -91.33, 156.42 | APE8-rot-na | 298.81 | APE67-dihe-out | -82.0, 103.94 | -93.42, 147.99 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 16.976 | S207D,T211D | None | None | XRAY | 2.26 | 0.213 | 0.236 | A | 290 | 267 | 20 | 0 | 0 | 15 | [[53, 314]] | 1.0 | 3fme | Homo sapiens | STE_MAP2K6_HUMAN | STE | 3.8e-85 | 291.3 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| MP2K6_HUMAN | 3VN9A | P52564 | 44 | 334 | 334.0 | ANK:401 | Type1 | Inactive | None | 12.484 | 16.452 | None | -156.07, 167.47 | 49.05, 65.77 | -66.48, -73.12 | 247.27, 104.01 | -116.78, -30.67 | na-na | na | 18.407 | Saltbr-na | 19.799 | HRD-out | -85.58, 116.13 | -89.6, 160.1 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 8.041 | ActLoopCT-out | nonTYR | APEdihe_aaiao | APEdist_oooo | APE10-dihe-na | -100.99, -122.29 | APE9-dihe-na | -158.81, 34.69 | APE8-dihe-in | -69.41, 135.75 | APE8-rot-na | 308.2 | APE67-dihe-out | -83.72, 102.27 | -50.21, 136.86 | APE12-dist-out | 19.857 | APE11-dist-out | 17.036 | APE10-dist-out | 16.653 | APE9-dist-out | 16.904 | None | None | None | XRAY | 2.6 | 0.265 | 0.28 | A | 340 | 291 | 0 | 0 | 0 | 0 | [[53, 314]] | 1.0 | 3vn9 | Homo sapiens | STE_MAP2K6_HUMAN | STE | 4.8e-85 | 291.0 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| MP2K6_HUMAN | 8A8MB | P52564 | 38 | 334 | 334.0 | AP2:60401 | Type1 | None | DFGin | 5.486 | 11.64 | BLAminus | -146.69, -172.97 | 54.53, 63.91 | -81.56, 13.5 | 331.49, 114.43 | -66.25, -37.97 | na-na | na | 8.615 | Saltbr-na | 5.512 | HRD-in | -64.64, -38.02 | 67.87, -2.84 | na-in-none | SNCain | in-none | ActLoopNT-in | 3.185 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | 999.0, -48.81 | 999.0, 999.0 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S207D,T211D | None | None | EM | 4.0 | 999.0 | 999.0 | B | 374 | 284 | 13 | 0 | 0 | 13 | [[53, 314]] | 1.0 | 8a8m | Homo sapiens | STE_MAP2K6_HUMAN | STE | 8.9e-85 | 290.1 | 3 | 257 | 255 | 196 | 197 | 198 | 200 | 202 | 82 | 99 | 103 | 176 | 178 | 177 | 179 | 239 | 223 | 218 | 217 | 216 | 215 | 214 | 213 | 212 | 130 | Dual specificity mitogen-activated protein kinase kinase 6 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
Hover over column headers for tooltip help
| SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
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