STE_MAP2K2 (Dual specificity mitogen-activated protein kinase kinase 2)

Total number of chains: 4
Active chains: 2
Uniprot: MP2K2_HUMAN
Kinase Domain Residues: 72 - 369
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% AF-P36507-K1A
DFGin BLBplus 2 50.0% 1S9IA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP2K2 AF-P36507-K1A P36507 64 377 400.0 No_ligand No_ligand Active DFGin 6.6424 14.2745 BLAminus -139.74, 178.8 58.58, 75.78 -90.71, 12.72 301.05, 101.27 -60.02, -30.56 in-in in 8.4919 Saltbr-in 2.6741 HRD-in -71.92, -42.37 65.73, 4.56 in-in-in SNCiii in-in ActLoopNT-in 2.9064 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.31, 158.43 APE9-dihe-na 95.29, 179.01 APE8-dihe-in -79.91, 122.36 APE8-rot-in 305.75 APE67-dihe-in -65.61, -11.1 -45.5, -50.73 APE12-dist-in 9.3115 APE11-dist-in 11.6165 APE10-dist-in 5.8527 APE9-dist-in 3.553 None None None AF2 -1.0 1.0 1.0 A 314.0 314.0 0 26 26 0 [[72, 369]] 1.0 AF-P36507-K1 STE_MAP2K2_HUMAN STE 9.9e-98 332.5 1.0 257.0 257.0 211 212 213 215 217 101 118 122 191 193 192 194.0 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2
MAP2K2 AF-P36507-K3A P36507 64 377 400.0 No_ligand No_ligand Active DFGin 6.4702 14.5358 BLAminus -143.71, -179.45 60.12, 68.57 -84.75, 8.39 298.47, 96.84 -61.1, -26.83 in-in in 8.6648 Saltbr-in 2.7041 HRD-in -69.54, -45.65 69.09, -5.81 in-in-in SNCiii in-in ActLoopNT-in 2.9595 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.57, 155.24 APE9-dihe-na 105.94, 179.49 APE8-dihe-in -81.15, 113.05 APE8-rot-in 309.58 APE67-dihe-in -64.25, -20.42 -57.25, -35.72 APE12-dist-in 8.6241 APE11-dist-in 11.0985 APE10-dist-in 5.1363 APE9-dist-in 4.1218 None None None AF2 -1.0 1.0 1.0 A 314.0 314.0 0 26 26 0 [[72, 369]] 1.0 AF-P36507-K3 STE_MAP2K2_HUMAN STE 9.9e-98 332.5 1.0 257.0 257.0 211 212 213 215 217 101 118 122 191 193 192 194.0 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2
MAP2K2 1S9IA P36507 60 393 400.0 ATP:535,5EA:1001 ATPlike,Type3 Inactive DFGin 6.2872 13.2689 BLBplus -139.34, -174.92 56.51, 21.27 -79.15, 150.55 47.45, 91.25 -79.77, 85.37 out-out out 15.5294 Saltbr-out 17.2975 HRD-out -62.14, 153.21 -129.12, 19.13 out-out-out SNCooo out-out ActLoopNT-out 8.8978 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 134.1 APE9-dihe-na -103.89, 62.93 APE8-dihe-out -65.91, -35.32 APE8-rot-in 354.81 APE67-dihe-out -93.63, 150.37 -174.34, 119.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 21.6182 APE9-dist-out 12.7323 None None None XRAY 3.2 0.294 0.364 A 354.0 303.0 31 26 22 4 [[72, 369]] 1.0 1s9i STE_MAP2K2_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 211 212 213 215 217 101 118 122 191 193 192 194.0 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2
MAP2K2 1S9IB P36507 59 389 400.0 ATP:537,5EA:1002 ATPlike,Type3 Inactive DFGin 6.2824 13.6383 BLBplus -139.5, 161.8 56.55, 60.44 -106.38, 150.17 37.7, 87.0 -78.89, 77.21 out-out out 15.5341 Saltbr-out 15.0044 HRD-out -92.42, 79.21 -68.62, 14.72 out-out-out SNCooo out-out ActLoopNT-out 9.5166 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -33.93 APE8-rot-out 15.08 APE67-dihe-out -144.19, 132.88 -117.04, 157.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.294 0.364 B 354.0 291.0 40 26 20 6 [[72, 369]] 1.0 1s9i STE_MAP2K2_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 211 212 213 215 217 101 118 122 191 193 192 194.0 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2

STE_MAP2K2 (Dual specificity mitogen-activated protein kinase kinase 2)

Total number of chains: 4
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% AF-P36507-K1A
DFGin BLBplus 2 50.0% 1S9IA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP2K2 MP2K2_HUMAN AF-P36507-K1A P36507 64 377 400.0 No_ligand No_ligand Active DFGin 6.6424 14.2745 BLAminus -139.74, 178.8 58.58, 75.78 -90.71, 12.72 301.05, 101.27 -60.02, -30.56 in-in in 8.4919 Saltbr-in 2.6741 HRD-in -71.92, -42.37 65.73, 4.56 in-in-in SNCiii in-in ActLoopNT-in 2.9064 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.31, 158.43 APE9-dihe-na 95.29, 179.01 APE8-dihe-in -79.91, 122.36 APE8-rot-in 305.75 APE67-dihe-in -65.61, -11.1 -45.5, -50.73 APE12-dist-in 9.3115 APE11-dist-in 11.6165 APE10-dist-in 5.8527 APE9-dist-in 3.553 None None None AF2 -1.0 1.0 1.0 A 314.0 314.0 0 26 26 0 [[72, 369]] 1.0 AF-P36507-K1 Homo sapiens STE_MAP2K2_HUMAN STE 9.9e-98 332.5 1.0 257.0 257.0 211 212 213 215 217 101 118 122 191 193 192 194.0 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2
MAP2K2 MP2K2_HUMAN AF-P36507-K3A P36507 64 377 400.0 No_ligand No_ligand Active DFGin 6.4702 14.5358 BLAminus -143.71, -179.45 60.12, 68.57 -84.75, 8.39 298.47, 96.84 -61.1, -26.83 in-in in 8.6648 Saltbr-in 2.7041 HRD-in -69.54, -45.65 69.09, -5.81 in-in-in SNCiii in-in ActLoopNT-in 2.9595 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.57, 155.24 APE9-dihe-na 105.94, 179.49 APE8-dihe-in -81.15, 113.05 APE8-rot-in 309.58 APE67-dihe-in -64.25, -20.42 -57.25, -35.72 APE12-dist-in 8.6241 APE11-dist-in 11.0985 APE10-dist-in 5.1363 APE9-dist-in 4.1218 None None None AF2 -1.0 1.0 1.0 A 314.0 314.0 0 26 26 0 [[72, 369]] 1.0 AF-P36507-K3 Homo sapiens STE_MAP2K2_HUMAN STE 9.9e-98 332.5 1.0 257.0 257.0 211 212 213 215 217 101 118 122 191 193 192 194.0 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2
MAP2K2 MP2K2_HUMAN 1S9IA P36507 60 393 400.0 ATP:535,5EA:1001 ATPlike,Type3 Inactive DFGin 6.2872 13.2689 BLBplus -139.34, -174.92 56.51, 21.27 -79.15, 150.55 47.45, 91.25 -79.77, 85.37 out-out out 15.5294 Saltbr-out 17.2975 HRD-out -62.14, 153.21 -129.12, 19.13 out-out-out SNCooo out-out ActLoopNT-out 8.8978 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 134.1 APE9-dihe-na -103.89, 62.93 APE8-dihe-out -65.91, -35.32 APE8-rot-in 354.81 APE67-dihe-out -93.63, 150.37 -174.34, 119.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 21.6182 APE9-dist-out 12.7323 None None None XRAY 3.2 0.294 0.364 A 354.0 303.0 31 26 22 4 [[72, 369]] 1.0 1s9i Homo sapiens STE_MAP2K2_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 211 212 213 215 217 101 118 122 191 193 192 194.0 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2
MAP2K2 MP2K2_HUMAN 1S9IB P36507 59 389 400.0 ATP:537,5EA:1002 ATPlike,Type3 Inactive DFGin 6.2824 13.6383 BLBplus -139.5, 161.8 56.55, 60.44 -106.38, 150.17 37.7, 87.0 -78.89, 77.21 out-out out 15.5341 Saltbr-out 15.0044 HRD-out -92.42, 79.21 -68.62, 14.72 out-out-out SNCooo out-out ActLoopNT-out 9.5166 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -33.93 APE8-rot-out 15.08 APE67-dihe-out -144.19, 132.88 -117.04, 157.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.294 0.364 B 354.0 291.0 40 26 20 6 [[72, 369]] 1.0 1s9i Homo sapiens STE_MAP2K2_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 211 212 213 215 217 101 118 122 191 193 192 194.0 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2

STE_MAP2K2 (Dual specificity mitogen-activated protein kinase kinase 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name