TKL_LIMK1 (LIM domain kinase 1)

Total number of chains: 20
Active chains: 7
Uniprot: LIMK1_HUMAN
Kinase Domain Residues: 339 - 606
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 45.0% AF-P53667-K1A
DFGout BBAminus 8 40.0% 7ATUB
DFGin None 2 10.0% 5HVKC
DFGin BLBplus 1 5.0% 7ATSA

Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
LIMK1 5L6WL P53667 330 633 647.0 AGS:60701 ATPlike Active DFGin 6.2348 14.3373 BLAminus -131.64, -166.52 46.75, 81.93 -92.83, 15.71 304.28, 98.92 -42.69, -49.84 in-in in 7.6644 Saltbr-in 2.6698 HRD-in -78.67, -47.86 69.62, -13.12 in-in-in SNCiii in-in ActLoopNT-in 3.0656 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -134.6, 165.2 APE9-dihe-na 100.19, 162.86 APE8-dihe-in -63.5, 131.5 APE8-rot-na 185.1 APE67-dihe-in -61.44, -31.47 -69.46, -29.71 APE12-dist-in 9.1162 APE11-dist-in 11.1338 APE10-dist-in 5.4376 APE9-dist-in 3.7616 None None None XRAY 2.53 0.229 0.284 L 310.0 288.0 16 42 26 16 [[339, 606]] 1.0 5l6w TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 5HVKA P53667 329 634 647.0 ANP:61001 ATPlike Active DFGin 6.4055 13.6462 BLAminus -145.46, 176.84 65.07, 82.49 -109.26, 24.73 304.62, 92.73 -71.79, -22.73 in-in in 7.7955 Saltbr-in 3.1595 HRD-in -70.8, -44.42 59.42, 18.52 in-in-in SNCiii in-in ActLoopNT-in 3.3239 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -139.63, 151.17 APE9-dihe-na 143.88, 171.7 APE8-dihe-in -71.51, 120.27 APE8-rot-na 199.31 APE67-dihe-in -66.59, -36.22 -54.03, -34.34 APE12-dist-in 9.3008 APE11-dist-in 11.0813 APE10-dist-in 5.6355 APE9-dist-in 3.574 D460N TPO508 TPO508 XRAY 3.5 0.275 0.31 A 315.0 293.0 13 42 29 13 [[339, 606]] 1.0 5hvk TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 AF-P53667-K1A P53667 331 614 647.0 No_ligand No_ligand Active DFGin 6.4021 13.541 BLAminus -132.91, 172.92 63.45, 83.32 -95.59, 15.47 307.89, 98.1 -56.0, -37.92 in-in in 8.0035 Saltbr-in 2.8756 HRD-in -72.18, -46.62 65.68, -7.95 in-in-in SNCiii in-in ActLoopNT-in 2.8147 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -147.55, 162.1 APE9-dihe-na 111.74, 171.85 APE8-dihe-in -70.23, 125.79 APE8-rot-na 190.49 APE67-dihe-in -72.63, -29.87 -60.16, -27.98 APE12-dist-in 8.9723 APE11-dist-in 11.3112 APE10-dist-in 5.6992 APE9-dist-in 3.7416 None None None AF2 -1.0 1.0 1.0 A 284.0 284.0 0 42 42 0 [[339, 606]] 1.0 AF-P53667-K1 TKL_LIMK1_HUMAN TKL 3.2e-77 265.6 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 AF-P53667-K3A P53667 331 614 647.0 No_ligand No_ligand Active DFGin 6.4364 13.0013 BLAminus -134.63, 176.85 57.56, 81.2 -91.01, 15.28 308.67, 101.9 -59.38, -29.77 in-in in 8.4189 Saltbr-in 2.7623 HRD-in -76.02, -44.69 64.99, -9.59 in-in-in SNCiii in-in ActLoopNT-in 2.8487 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -146.38, 153.96 APE9-dihe-na 114.91, -178.52 APE8-dihe-in -81.56, 123.45 APE8-rot-na 187.77 APE67-dihe-in -69.46, -22.15 -58.27, -25.04 APE12-dist-in 9.6764 APE11-dist-in 11.3408 APE10-dist-in 5.6872 APE9-dist-in 4.083 None None None AF2 -1.0 1.0 1.0 A 284.0 284.0 0 42 42 0 [[339, 606]] 1.0 AF-P53667-K3 TKL_LIMK1_HUMAN TKL 3.2e-77 265.6 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 3S95A P53667 330 637 647.0 STU:60001 Type1 Active DFGin 6.5043 14.0715 BLAminus -132.12, 176.01 61.94, 79.29 -96.74, 17.56 299.36, 104.43 -67.12, -24.68 in-in in 7.4783 Saltbr-in 2.7701 HRD-in -69.3, -54.34 71.96, -1.22 in-in-in SNCiii in-in ActLoopNT-in 2.8744 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -137.33, 152.92 APE9-dihe-na 118.99, 175.51 APE8-dihe-in -76.56, 127.6 APE8-rot-na 188.61 APE67-dihe-in -66.82, -23.07 -64.42, -23.72 APE12-dist-in 9.2185 APE11-dist-in 11.4435 APE10-dist-in 5.6449 APE9-dist-in 3.7458 None None None XRAY 1.65 0.157 0.181 A 310.0 288.0 20 42 22 20 [[339, 606]] 1.0 3s95 TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 3S95B P53667 330 637 647.0 STU:60001 Type1 Active DFGin 6.4648 13.7229 BLAminus -137.18, 172.16 66.04, 80.35 -97.8, 13.37 302.38, 103.91 -61.7, -26.69 in-in in 7.8062 Saltbr-in 2.5961 HRD-in -67.95, -51.91 71.9, -3.03 in-in-in SNCiii in-in ActLoopNT-in 2.8557 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -131.01, 146.52 APE9-dihe-na 126.16, 169.25 APE8-dihe-in -67.25, 124.73 APE8-rot-na 183.11 APE67-dihe-in -72.71, -16.93 -64.76, -21.17 APE12-dist-in 9.1152 APE11-dist-in 11.2682 APE10-dist-in 5.4051 APE9-dist-in 3.7833 None None None XRAY 1.65 0.157 0.181 B 310.0 288.0 20 42 22 20 [[339, 606]] 1.0 3s95 TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 8AAUL P53667 330 634 647.0 LH0:60702 Type1 Active DFGin 6.786 14.3596 BLAminus -139.69, 179.69 63.59, 84.26 -97.44, 26.6 302.89, 100.12 -69.05, -22.82 in-in in 8.0099 Saltbr-in 2.978 HRD-in -77.51, -55.38 71.25, -0.11 in-in-in SNCiii in-in ActLoopNT-in 2.9518 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -142.5, 160.37 APE9-dihe-na 102.43, 175.55 APE8-dihe-in -76.32, 127.47 APE8-rot-na 188.29 APE67-dihe-in -71.03, -16.49 -57.76, -26.74 APE12-dist-in 9.2056 APE11-dist-in 11.6205 APE10-dist-in 5.8444 APE9-dist-in 3.7263 None None None XRAY 1.74 0.213 0.24 L 310.0 289.0 16 42 26 16 [[339, 606]] 1.0 8aau TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 5HVJA P53667 329 633 647.0 ANP:1000 ATPlike Inactive DFGin 6.1667 14.0183 BLAminus -132.74, -177.4 60.53, 87.07 -109.1, 23.76 308.69, 90.48 -66.78, -25.98 in-in in 8.1192 Saltbr-in 2.7865 HRD-in -65.97, -50.93 68.53, 0.88 in-in-out SNCiio in-out ActLoopNT-in 2.9434 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oiio APE10-dihe-na -124.58, 95.6 APE9-dihe-na 76.06, -115.03 APE8-dihe-in -111.26, 122.06 APE8-rot-na 224.18 APE67-dihe-in -69.88, -30.27 -73.34, -10.37 APE12-dist-out 14.7577 APE11-dist-in 11.8135 APE10-dist-in 6.9252 APE9-dist-out 6.3724 D460N None None XRAY 2.2 0.208 0.252 A 315.0 283.0 22 42 20 22 [[339, 606]] 1.0 5hvj TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 7ATSA P53667 330 634 647.0 RXQ:60701 Type1.5_Back Inactive DFGin 6.3253 13.0202 BLBplus -148.3, 165.76 77.89, 46.61 -88.39, 148.29 39.39, 66.52 72.51, 999.0 out-none out 10.7167 Saltbr-none 999.0 HRD-in -70.62, -43.74 68.99, -24.38 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.94, 2.16 999.0, -60.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.251 0.312 A 310.0 273.0 32 42 10 32 [[339, 606]] 1.0 7ats TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 5HVKC P53667 329 633 647.0 ANP:60701 ATPlike Inactive DFGin 6.0783 13.9339 None -149.69, 172.69 -101.87, 169.41 -110.21, 23.25 306.34, 92.8 -73.91, -25.16 in-out in 7.8911 Saltbr-out 3.6442 HRD-in -72.39, -44.63 59.79, 17.6 out-in-in SNCoii in-in ActLoopNT-in 3.0698 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -140.53, 148.22 APE9-dihe-na 140.89, 172.08 APE8-dihe-in -72.12, 119.75 APE8-rot-na 199.66 APE67-dihe-in -64.48, -35.33 -54.5, -33.22 APE12-dist-in 8.6689 APE11-dist-in 11.1988 APE10-dist-in 5.8992 APE9-dist-in 3.5423 D460N TPO508 TPO508 XRAY 3.5 0.275 0.31 C 315.0 291.0 14 42 28 14 [[339, 606]] 1.0 5hvk TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 5NXCL P53667 330 632 647.0 9DB:60701 Type1 Inactive DFGin 6.1921 12.9336 None -122.26, 162.54 70.04, 26.42 -74.72, 999.0 43.09, 84.18 999.0, 999.0 out-out out 14.186 Saltbr-out 16.3784 HRD-in -67.42, -56.12 78.54, -18.62 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -87.18 APE8-dihe-in -64.64, 140.22 APE8-rot-na 296.78 APE67-dihe-in -58.15, -27.29 -88.8, 19.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.065 None None None XRAY 2.25 0.242 0.298 L 310.0 272.0 31 42 11 31 [[339, 606]] 1.0 5nxc TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 7B8WA P53667 330 633 647.0 T3B:701 Type2 Inactive DFGout 16.6661 11.4926 BBAminus -108.83, 173.28 -137.19, 82.52 -63.27, -30.52 292.34, 152.89 -108.41, 12.13 out-out out 15.4181 Saltbr-out 15.2387 HRD-in -60.02, -54.69 66.73, -7.71 out-out-none SNCoon out-none ActLoopNT-out 4.2286 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 173.73 APE8-rot-na 249.62 APE67-dihe-in -62.65, -17.18 -62.83, -26.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.209 0.286 A 310.0 279.0 25 42 17 25 [[339, 606]] 1.0 7b8w TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 7B8WB P53667 330 632 647.0 T3B:701 Type2 Inactive DFGout 16.7675 11.0591 BBAminus -106.35, 172.19 -132.14, 77.15 -57.43, -29.76 284.14, 171.59 -103.49, 0.05 out-out out 15.4479 Saltbr-out 15.4371 HRD-in -64.64, -57.77 78.09, -18.57 out-out-none SNCoon out-none ActLoopNT-out 4.5347 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 157.36 APE8-rot-na 234.58 APE67-dihe-in -57.94, -33.17 -72.5, -19.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.209 0.286 B 310.0 275.0 28 42 17 25 [[339, 606]] 1.0 7b8w TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 7B8WC P53667 330 632 647.0 T3B:701 Type2 Inactive DFGout 16.4887 11.2611 BBAminus -111.78, 177.07 -146.46, 75.42 -59.24, -37.03 298.62, 151.29 -94.08, 6.16 out-out out 15.4237 Saltbr-out 15.3287 HRD-in -60.88, -61.88 71.56, -6.41 out-out-none SNCoon out-none ActLoopNT-out 4.3299 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -76.99, 161.6 999.0, -48.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.209 0.286 C 310.0 276.0 27 42 16 26 [[339, 606]] 1.0 7b8w TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 7B8WD P53667 331 632 647.0 T3B:701 Type2 Inactive DFGout 16.7849 11.4189 BBAminus -104.89, 177.21 -139.94, 82.99 -62.41, -30.49 296.01, 157.77 -99.63, 2.65 out-out out 15.6383 Saltbr-out 15.3644 HRD-in -83.91, -55.17 72.93, -9.44 out-out-none SNCoon out-none ActLoopNT-out 4.4525 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -172.92 APE8-rot-na 308.11 APE67-dihe-in -63.89, -29.07 -79.57, -3.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.209 0.286 D 310.0 273.0 29 42 17 25 [[339, 606]] 1.0 7b8w TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 7ATUA P53667 330 634 647.0 RXN:60701 Type3 Inactive DFGout 14.9876 10.0013 BBAminus -109.21, 174.28 -142.39, 83.58 -74.29, -18.32 285.18, 140.01 -111.7, 18.04 out-out out 16.0842 Saltbr-out 15.4511 HRD-in -57.8, -51.16 74.51, -19.19 out-out-out SNCooo out-out ActLoopNT-out 4.3287 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -67.49, -72.98 APE9-dihe-na -69.77, -144.94 APE8-dihe-in -75.87, 154.24 APE8-rot-na 319.69 APE67-dihe-in -61.11, -47.04 -83.72, 16.19 APE12-dist-in 12.8646 APE11-dist-in 10.2081 APE10-dist-out 8.7969 APE9-dist-out 10.3054 None None None XRAY 2.8 0.244 0.316 A 310.0 275.0 26 42 21 21 [[339, 606]] 1.0 7atu TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 7ATUB P53667 330 636 647.0 RXN:60701 Type3 Inactive DFGout 14.8706 10.3854 BBAminus -106.42, 171.63 -143.53, 69.8 -63.76, -14.73 294.73, 133.01 -108.57, -0.53 out-out out 15.698 Saltbr-out 15.9291 HRD-in -85.21, -51.0 77.42, -16.83 out-out-out SNCooo out-out ActLoopNT-out 4.3537 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -53.4, -74.11 APE9-dihe-na -79.86, -149.85 APE8-dihe-in -70.91, 144.09 APE8-rot-na 286.44 APE67-dihe-in -64.41, -40.03 -82.97, 20.25 APE12-dist-in 12.9593 APE11-dist-in 10.3577 APE10-dist-out 8.5329 APE9-dist-out 10.0774 None None None XRAY 2.8 0.244 0.316 B 310.0 286.0 21 42 22 20 [[339, 606]] 1.0 7atu TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 7ATUC P53667 350 632 647.0 RXN:60701 Type3 Inactive DFGout 14.7184 10.0327 BBAminus -88.15, 177.18 -140.99, 72.99 -70.21, -9.41 281.23, 139.59 -112.2, 13.51 out-none out 16.3341 Saltbr-none 999.0 HRD-in -66.72, -54.87 73.93, -4.49 none-out-none SNCnon out-none ActLoopNT-out 4.1731 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.36 APE8-rot-na 315.64 APE67-dihe-in -46.43, -53.49 -85.62, 16.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.244 0.316 C 310.0 244.0 50 42 16 26 [[339, 606]] 1.0 7atu TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 7ATUD P53667 354 632 647.0 RXN:60701 Type3 Inactive DFGout 15.3308 10.2244 BBAminus -128.0, -173.91 -147.27, 77.77 -61.68, -36.22 282.23, 139.99 -104.61, 32.02 out-none out 15.9178 Saltbr-none 999.0 HRD-in -81.48, -48.99 75.04, -24.96 none-out-out SNCnoo out-out ActLoopNT-out 4.3589 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 90.29 APE8-dihe-in -64.34, 138.15 APE8-rot-none 999.0 APE67-dihe-in -66.61, -40.13 -99.55, 33.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.651 None None None XRAY 2.8 0.244 0.316 D 310.0 243.0 50 42 17 25 [[339, 606]] 1.0 7atu TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 5HVJB P53667 330 637 647.0 No_ligand No_ligand None DFGin 6.3114 14.4704 BLAminus -141.63, -173.95 58.14, 85.14 -109.93, 21.77 307.16, 94.0 -69.69, -19.18 in-in in 8.3213 Saltbr-in 3.5002 HRD-in -62.14, -52.6 65.87, 6.3 in-in-none SNCiin in-none ActLoopNT-in 2.8336 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_niii APE10-dihe-na -122.6, 132.58 APE9-dihe-na 145.85, 159.27 APE8-dihe-in -67.15, 124.01 APE8-rot-na 289.03 APE67-dihe-in -68.41, -22.95 -71.76, -27.06 APE12-dist-none 999.0 APE11-dist-in 10.5032 APE10-dist-in 6.9679 APE9-dist-in 4.7796 D460N None None XRAY 2.2 0.208 0.252 B 315.0 284.0 24 42 18 24 [[339, 606]] 1.0 5hvj TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1

TKL_LIMK1 (LIM domain kinase 1)

Total number of chains: 20
Active chains: 7
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 45.0% AF-P53667-K1A
DFGout BBAminus 8 40.0% 7ATUB
DFGin None 2 10.0% 5HVKC
DFGin BLBplus 1 5.0% 7ATSA

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
LIMK1 LIMK1_HUMAN 5L6WL P53667 330 633 647.0 AGS:60701 ATPlike Active DFGin 6.2348 14.3373 BLAminus -131.64, -166.52 46.75, 81.93 -92.83, 15.71 304.28, 98.92 -42.69, -49.84 in-in in 7.6644 Saltbr-in 2.6698 HRD-in -78.67, -47.86 69.62, -13.12 in-in-in SNCiii in-in ActLoopNT-in 3.0656 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -134.6, 165.2 APE9-dihe-na 100.19, 162.86 APE8-dihe-in -63.5, 131.5 APE8-rot-na 185.1 APE67-dihe-in -61.44, -31.47 -69.46, -29.71 APE12-dist-in 9.1162 APE11-dist-in 11.1338 APE10-dist-in 5.4376 APE9-dist-in 3.7616 None None None XRAY 2.53 0.229 0.284 L 310.0 288.0 16 42 26 16 [[339, 606]] 1.0 5l6w Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 5HVKA P53667 329 634 647.0 ANP:61001 ATPlike Active DFGin 6.4055 13.6462 BLAminus -145.46, 176.84 65.07, 82.49 -109.26, 24.73 304.62, 92.73 -71.79, -22.73 in-in in 7.7955 Saltbr-in 3.1595 HRD-in -70.8, -44.42 59.42, 18.52 in-in-in SNCiii in-in ActLoopNT-in 3.3239 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -139.63, 151.17 APE9-dihe-na 143.88, 171.7 APE8-dihe-in -71.51, 120.27 APE8-rot-na 199.31 APE67-dihe-in -66.59, -36.22 -54.03, -34.34 APE12-dist-in 9.3008 APE11-dist-in 11.0813 APE10-dist-in 5.6355 APE9-dist-in 3.574 D460N TPO508 TPO508 XRAY 3.5 0.275 0.31 A 315.0 293.0 13 42 29 13 [[339, 606]] 1.0 5hvk Homo sapiens TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN AF-P53667-K1A P53667 331 614 647.0 No_ligand No_ligand Active DFGin 6.4021 13.541 BLAminus -132.91, 172.92 63.45, 83.32 -95.59, 15.47 307.89, 98.1 -56.0, -37.92 in-in in 8.0035 Saltbr-in 2.8756 HRD-in -72.18, -46.62 65.68, -7.95 in-in-in SNCiii in-in ActLoopNT-in 2.8147 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -147.55, 162.1 APE9-dihe-na 111.74, 171.85 APE8-dihe-in -70.23, 125.79 APE8-rot-na 190.49 APE67-dihe-in -72.63, -29.87 -60.16, -27.98 APE12-dist-in 8.9723 APE11-dist-in 11.3112 APE10-dist-in 5.6992 APE9-dist-in 3.7416 None None None AF2 -1.0 1.0 1.0 A 284.0 284.0 0 42 42 0 [[339, 606]] 1.0 AF-P53667-K1 Homo sapiens TKL_LIMK1_HUMAN TKL 3.2e-77 265.6 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN AF-P53667-K3A P53667 331 614 647.0 No_ligand No_ligand Active DFGin 6.4364 13.0013 BLAminus -134.63, 176.85 57.56, 81.2 -91.01, 15.28 308.67, 101.9 -59.38, -29.77 in-in in 8.4189 Saltbr-in 2.7623 HRD-in -76.02, -44.69 64.99, -9.59 in-in-in SNCiii in-in ActLoopNT-in 2.8487 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -146.38, 153.96 APE9-dihe-na 114.91, -178.52 APE8-dihe-in -81.56, 123.45 APE8-rot-na 187.77 APE67-dihe-in -69.46, -22.15 -58.27, -25.04 APE12-dist-in 9.6764 APE11-dist-in 11.3408 APE10-dist-in 5.6872 APE9-dist-in 4.083 None None None AF2 -1.0 1.0 1.0 A 284.0 284.0 0 42 42 0 [[339, 606]] 1.0 AF-P53667-K3 Homo sapiens TKL_LIMK1_HUMAN TKL 3.2e-77 265.6 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 3S95A P53667 330 637 647.0 STU:60001 Type1 Active DFGin 6.5043 14.0715 BLAminus -132.12, 176.01 61.94, 79.29 -96.74, 17.56 299.36, 104.43 -67.12, -24.68 in-in in 7.4783 Saltbr-in 2.7701 HRD-in -69.3, -54.34 71.96, -1.22 in-in-in SNCiii in-in ActLoopNT-in 2.8744 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -137.33, 152.92 APE9-dihe-na 118.99, 175.51 APE8-dihe-in -76.56, 127.6 APE8-rot-na 188.61 APE67-dihe-in -66.82, -23.07 -64.42, -23.72 APE12-dist-in 9.2185 APE11-dist-in 11.4435 APE10-dist-in 5.6449 APE9-dist-in 3.7458 None None None XRAY 1.65 0.157 0.181 A 310.0 288.0 20 42 22 20 [[339, 606]] 1.0 3s95 Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 3S95B P53667 330 637 647.0 STU:60001 Type1 Active DFGin 6.4648 13.7229 BLAminus -137.18, 172.16 66.04, 80.35 -97.8, 13.37 302.38, 103.91 -61.7, -26.69 in-in in 7.8062 Saltbr-in 2.5961 HRD-in -67.95, -51.91 71.9, -3.03 in-in-in SNCiii in-in ActLoopNT-in 2.8557 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -131.01, 146.52 APE9-dihe-na 126.16, 169.25 APE8-dihe-in -67.25, 124.73 APE8-rot-na 183.11 APE67-dihe-in -72.71, -16.93 -64.76, -21.17 APE12-dist-in 9.1152 APE11-dist-in 11.2682 APE10-dist-in 5.4051 APE9-dist-in 3.7833 None None None XRAY 1.65 0.157 0.181 B 310.0 288.0 20 42 22 20 [[339, 606]] 1.0 3s95 Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 8AAUL P53667 330 634 647.0 LH0:60702 Type1 Active DFGin 6.786 14.3596 BLAminus -139.69, 179.69 63.59, 84.26 -97.44, 26.6 302.89, 100.12 -69.05, -22.82 in-in in 8.0099 Saltbr-in 2.978 HRD-in -77.51, -55.38 71.25, -0.11 in-in-in SNCiii in-in ActLoopNT-in 2.9518 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -142.5, 160.37 APE9-dihe-na 102.43, 175.55 APE8-dihe-in -76.32, 127.47 APE8-rot-na 188.29 APE67-dihe-in -71.03, -16.49 -57.76, -26.74 APE12-dist-in 9.2056 APE11-dist-in 11.6205 APE10-dist-in 5.8444 APE9-dist-in 3.7263 None None None XRAY 1.74 0.213 0.24 L 310.0 289.0 16 42 26 16 [[339, 606]] 1.0 8aau Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 5HVJA P53667 329 633 647.0 ANP:1000 ATPlike Inactive DFGin 6.1667 14.0183 BLAminus -132.74, -177.4 60.53, 87.07 -109.1, 23.76 308.69, 90.48 -66.78, -25.98 in-in in 8.1192 Saltbr-in 2.7865 HRD-in -65.97, -50.93 68.53, 0.88 in-in-out SNCiio in-out ActLoopNT-in 2.9434 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oiio APE10-dihe-na -124.58, 95.6 APE9-dihe-na 76.06, -115.03 APE8-dihe-in -111.26, 122.06 APE8-rot-na 224.18 APE67-dihe-in -69.88, -30.27 -73.34, -10.37 APE12-dist-out 14.7577 APE11-dist-in 11.8135 APE10-dist-in 6.9252 APE9-dist-out 6.3724 D460N None None XRAY 2.2 0.208 0.252 A 315.0 283.0 22 42 20 22 [[339, 606]] 1.0 5hvj Homo sapiens TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 7ATSA P53667 330 634 647.0 RXQ:60701 Type1.5_Back Inactive DFGin 6.3253 13.0202 BLBplus -148.3, 165.76 77.89, 46.61 -88.39, 148.29 39.39, 66.52 72.51, 999.0 out-none out 10.7167 Saltbr-none 999.0 HRD-in -70.62, -43.74 68.99, -24.38 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.94, 2.16 999.0, -60.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.251 0.312 A 310.0 273.0 32 42 10 32 [[339, 606]] 1.0 7ats Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 5HVKC P53667 329 633 647.0 ANP:60701 ATPlike Inactive DFGin 6.0783 13.9339 None -149.69, 172.69 -101.87, 169.41 -110.21, 23.25 306.34, 92.8 -73.91, -25.16 in-out in 7.8911 Saltbr-out 3.6442 HRD-in -72.39, -44.63 59.79, 17.6 out-in-in SNCoii in-in ActLoopNT-in 3.0698 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -140.53, 148.22 APE9-dihe-na 140.89, 172.08 APE8-dihe-in -72.12, 119.75 APE8-rot-na 199.66 APE67-dihe-in -64.48, -35.33 -54.5, -33.22 APE12-dist-in 8.6689 APE11-dist-in 11.1988 APE10-dist-in 5.8992 APE9-dist-in 3.5423 D460N TPO508 TPO508 XRAY 3.5 0.275 0.31 C 315.0 291.0 14 42 28 14 [[339, 606]] 1.0 5hvk Homo sapiens TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 5NXCL P53667 330 632 647.0 9DB:60701 Type1 Inactive DFGin 6.1921 12.9336 None -122.26, 162.54 70.04, 26.42 -74.72, 999.0 43.09, 84.18 999.0, 999.0 out-out out 14.186 Saltbr-out 16.3784 HRD-in -67.42, -56.12 78.54, -18.62 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -87.18 APE8-dihe-in -64.64, 140.22 APE8-rot-na 296.78 APE67-dihe-in -58.15, -27.29 -88.8, 19.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.065 None None None XRAY 2.25 0.242 0.298 L 310.0 272.0 31 42 11 31 [[339, 606]] 1.0 5nxc Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 7B8WA P53667 330 633 647.0 T3B:701 Type2 Inactive DFGout 16.6661 11.4926 BBAminus -108.83, 173.28 -137.19, 82.52 -63.27, -30.52 292.34, 152.89 -108.41, 12.13 out-out out 15.4181 Saltbr-out 15.2387 HRD-in -60.02, -54.69 66.73, -7.71 out-out-none SNCoon out-none ActLoopNT-out 4.2286 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 173.73 APE8-rot-na 249.62 APE67-dihe-in -62.65, -17.18 -62.83, -26.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.209 0.286 A 310.0 279.0 25 42 17 25 [[339, 606]] 1.0 7b8w Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 7B8WB P53667 330 632 647.0 T3B:701 Type2 Inactive DFGout 16.7675 11.0591 BBAminus -106.35, 172.19 -132.14, 77.15 -57.43, -29.76 284.14, 171.59 -103.49, 0.05 out-out out 15.4479 Saltbr-out 15.4371 HRD-in -64.64, -57.77 78.09, -18.57 out-out-none SNCoon out-none ActLoopNT-out 4.5347 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 157.36 APE8-rot-na 234.58 APE67-dihe-in -57.94, -33.17 -72.5, -19.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.209 0.286 B 310.0 275.0 28 42 17 25 [[339, 606]] 1.0 7b8w Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 7B8WC P53667 330 632 647.0 T3B:701 Type2 Inactive DFGout 16.4887 11.2611 BBAminus -111.78, 177.07 -146.46, 75.42 -59.24, -37.03 298.62, 151.29 -94.08, 6.16 out-out out 15.4237 Saltbr-out 15.3287 HRD-in -60.88, -61.88 71.56, -6.41 out-out-none SNCoon out-none ActLoopNT-out 4.3299 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -76.99, 161.6 999.0, -48.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.209 0.286 C 310.0 276.0 27 42 16 26 [[339, 606]] 1.0 7b8w Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 7B8WD P53667 331 632 647.0 T3B:701 Type2 Inactive DFGout 16.7849 11.4189 BBAminus -104.89, 177.21 -139.94, 82.99 -62.41, -30.49 296.01, 157.77 -99.63, 2.65 out-out out 15.6383 Saltbr-out 15.3644 HRD-in -83.91, -55.17 72.93, -9.44 out-out-none SNCoon out-none ActLoopNT-out 4.4525 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -172.92 APE8-rot-na 308.11 APE67-dihe-in -63.89, -29.07 -79.57, -3.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.209 0.286 D 310.0 273.0 29 42 17 25 [[339, 606]] 1.0 7b8w Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 7ATUA P53667 330 634 647.0 RXN:60701 Type3 Inactive DFGout 14.9876 10.0013 BBAminus -109.21, 174.28 -142.39, 83.58 -74.29, -18.32 285.18, 140.01 -111.7, 18.04 out-out out 16.0842 Saltbr-out 15.4511 HRD-in -57.8, -51.16 74.51, -19.19 out-out-out SNCooo out-out ActLoopNT-out 4.3287 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -67.49, -72.98 APE9-dihe-na -69.77, -144.94 APE8-dihe-in -75.87, 154.24 APE8-rot-na 319.69 APE67-dihe-in -61.11, -47.04 -83.72, 16.19 APE12-dist-in 12.8646 APE11-dist-in 10.2081 APE10-dist-out 8.7969 APE9-dist-out 10.3054 None None None XRAY 2.8 0.244 0.316 A 310.0 275.0 26 42 21 21 [[339, 606]] 1.0 7atu Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 7ATUB P53667 330 636 647.0 RXN:60701 Type3 Inactive DFGout 14.8706 10.3854 BBAminus -106.42, 171.63 -143.53, 69.8 -63.76, -14.73 294.73, 133.01 -108.57, -0.53 out-out out 15.698 Saltbr-out 15.9291 HRD-in -85.21, -51.0 77.42, -16.83 out-out-out SNCooo out-out ActLoopNT-out 4.3537 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -53.4, -74.11 APE9-dihe-na -79.86, -149.85 APE8-dihe-in -70.91, 144.09 APE8-rot-na 286.44 APE67-dihe-in -64.41, -40.03 -82.97, 20.25 APE12-dist-in 12.9593 APE11-dist-in 10.3577 APE10-dist-out 8.5329 APE9-dist-out 10.0774 None None None XRAY 2.8 0.244 0.316 B 310.0 286.0 21 42 22 20 [[339, 606]] 1.0 7atu Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 7ATUC P53667 350 632 647.0 RXN:60701 Type3 Inactive DFGout 14.7184 10.0327 BBAminus -88.15, 177.18 -140.99, 72.99 -70.21, -9.41 281.23, 139.59 -112.2, 13.51 out-none out 16.3341 Saltbr-none 999.0 HRD-in -66.72, -54.87 73.93, -4.49 none-out-none SNCnon out-none ActLoopNT-out 4.1731 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.36 APE8-rot-na 315.64 APE67-dihe-in -46.43, -53.49 -85.62, 16.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.244 0.316 C 310.0 244.0 50 42 16 26 [[339, 606]] 1.0 7atu Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 7ATUD P53667 354 632 647.0 RXN:60701 Type3 Inactive DFGout 15.3308 10.2244 BBAminus -128.0, -173.91 -147.27, 77.77 -61.68, -36.22 282.23, 139.99 -104.61, 32.02 out-none out 15.9178 Saltbr-none 999.0 HRD-in -81.48, -48.99 75.04, -24.96 none-out-out SNCnoo out-out ActLoopNT-out 4.3589 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 90.29 APE8-dihe-in -64.34, 138.15 APE8-rot-none 999.0 APE67-dihe-in -66.61, -40.13 -99.55, 33.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.651 None None None XRAY 2.8 0.244 0.316 D 310.0 243.0 50 42 17 25 [[339, 606]] 1.0 7atu Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
LIMK1 LIMK1_HUMAN 5HVJB P53667 330 637 647.0 No_ligand No_ligand None DFGin 6.3114 14.4704 BLAminus -141.63, -173.95 58.14, 85.14 -109.93, 21.77 307.16, 94.0 -69.69, -19.18 in-in in 8.3213 Saltbr-in 3.5002 HRD-in -62.14, -52.6 65.87, 6.3 in-in-none SNCiin in-none ActLoopNT-in 2.8336 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_niii APE10-dihe-na -122.6, 132.58 APE9-dihe-na 145.85, 159.27 APE8-dihe-in -67.15, 124.01 APE8-rot-na 289.03 APE67-dihe-in -68.41, -22.95 -71.76, -27.06 APE12-dist-none 999.0 APE11-dist-in 10.5032 APE10-dist-in 6.9679 APE9-dist-in 4.7796 D460N None None XRAY 2.2 0.208 0.252 B 315.0 284.0 24 42 18 24 [[339, 606]] 1.0 5hvj Homo sapiens TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1

TKL_LIMK1 (LIM domain kinase 1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name