TYR_ERBB2 (Receptor tyrosine-protein kinase erbB-2)

Total number of chains: 19
Active chains: 2
Uniprot: ERBB2_HUMAN
Kinase Domain Residues: 720 - 978
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 10 52.6% 3PP0A
DFGin BLAminus 4 21.1% AF-P04626-K1A
DFGin BLBminus 2 10.5% 7PCDA
DFGin BLBplus 1 5.3% 7JXHE
DFGout None 1 5.3% 8U8XA
None None 1 5.3% 8VB5A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P04626-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 712 - 986 0 None None Receptor tyrosine-protein kinase erbB-2
AF-P04626-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 712 - 986 0 None None Receptor tyrosine-protein kinase erbB-2
3RCDB 3.21 Inactive DFGin‑BLAminus out-out none-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 713 - 1010 0 None None Receptor tyrosine-protein kinase erbB-2
3RCDD 3.21 Inactive DFGin‑BLAminus out-out none-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 713 - 1010 0 None None Receptor tyrosine-protein kinase erbB-2
7PCDA 1.77 Inactive DFGin‑BLBminus out-out out-none TYR APEdihe_nniai APEdist_aaai 70I Type1.5_Back 710 - 991 0 None None Receptor tyrosine-protein kinase erbB-2
7JXHA 3.27 Inactive DFGin‑BLBminus out-out out-out TYR APEdihe_nniai APEdist_aaao VOY Type1.5_Back 706 - 992 0 None None Receptor tyrosine-protein kinase erbB-2
7JXHE 3.27 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan VOY Type1.5_Back 709 - 992 0 None None Receptor tyrosine-protein kinase erbB-2
7JXHB 3.27 Inactive DFGin‑None out-out none-out TYR APEdihe_oiiai APEdist_aaai VOY Type1.5_Back 707 - 996 0 None None Receptor tyrosine-protein kinase erbB-2
7JXHC 3.27 Inactive DFGin‑None out-out in-out TYR APEdihe_oiiai APEdist_aaai VOY Type1.5_Back 707 - 992 0 None None Receptor tyrosine-protein kinase erbB-2
7JXHD 3.27 Inactive DFGin‑None out-out in-none TYR APEdihe_niiai APEdist_aaai VOY Type1.5_Back 707 - 992 0 None None Receptor tyrosine-protein kinase erbB-2
7JXHF 3.27 Inactive DFGin‑None out-out out-none TYR APEdihe_nniai APEdist_aaai VOY Type1.5_Back 713 - 991 0 None None Receptor tyrosine-protein kinase erbB-2
7JXHG 3.27 Inactive DFGin‑None out-out in-none TYR APEdihe_nniai APEdist_aaai VOY Type1.5_Back 706 - 992 0 None None Receptor tyrosine-protein kinase erbB-2
7JXHH 3.27 Inactive DFGin‑None out-out in-out TYR APEdihe_oiiai APEdist_aaai VOY Type1.5_Back 707 - 992 0 None None Receptor tyrosine-protein kinase erbB-2
3PP0A 2.25 Inactive DFGin‑None out-out in-in TYR APEdihe_iiiai APEdist_aaai 03Q Type1.5_Back 706 - 993 0 None M706A,Q711L,M712L Receptor tyrosine-protein kinase erbB-2
3PP0B 2.25 Inactive DFGin‑None out-out in-out TYR APEdihe_oiiai APEdist_aaai 03Q Type1.5_Back 706 - 1009 0 None M706A,Q711L,M712L Receptor tyrosine-protein kinase erbB-2
3RCDA 3.21 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 03P Type1.5_Back 713 - 1022 0 None None Receptor tyrosine-protein kinase erbB-2
3RCDC 3.21 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 03P Type1.5_Back 713 - 1022 0 None None Receptor tyrosine-protein kinase erbB-2
8U8XA 1.69 Inactive DFGout‑None out-out out-out TYR APEdihe_iiiai APEdist_aaao W9N Type1 712 - 1024 0 None None Receptor tyrosine-protein kinase erbB-2
8VB5A 1.48 Inactive None‑None out-out out-out TYR APEdihe_iiiai APEdist_aaao A1AAC Type1 706 - 990 0 None None Receptor tyrosine-protein kinase erbB-2

TYR_ERBB2 (Receptor tyrosine-protein kinase erbB-2)

Total number of chains: 19
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 10 52.6% 3PP0A
DFGin BLAminus 4 21.1% AF-P04626-K1A
DFGin BLBminus 2 10.5% 7PCDA
DFGin BLBplus 1 5.3% 7JXHE
DFGout None 1 5.3% 8U8XA
None None 1 5.3% 8VB5A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ERBB2_HUMAN AF-P04626-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 712 - 986 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN AF-P04626-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 712 - 986 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 3RCDB 3.21 Inactive DFGin‑BLAminus out-out none-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 713 - 1010 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 3RCDD 3.21 Inactive DFGin‑BLAminus out-out none-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 713 - 1010 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 7PCDA 1.77 Inactive DFGin‑BLBminus out-out out-none TYR APEdihe_nniai APEdist_aaai 70I Type1.5_Back 710 - 991 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 7JXHA 3.27 Inactive DFGin‑BLBminus out-out out-out TYR APEdihe_nniai APEdist_aaao VOY Type1.5_Back 706 - 992 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 7JXHE 3.27 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan VOY Type1.5_Back 709 - 992 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 7JXHB 3.27 Inactive DFGin‑None out-out none-out TYR APEdihe_oiiai APEdist_aaai VOY Type1.5_Back 707 - 996 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 7JXHC 3.27 Inactive DFGin‑None out-out in-out TYR APEdihe_oiiai APEdist_aaai VOY Type1.5_Back 707 - 992 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 7JXHD 3.27 Inactive DFGin‑None out-out in-none TYR APEdihe_niiai APEdist_aaai VOY Type1.5_Back 707 - 992 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 7JXHF 3.27 Inactive DFGin‑None out-out out-none TYR APEdihe_nniai APEdist_aaai VOY Type1.5_Back 713 - 991 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 7JXHG 3.27 Inactive DFGin‑None out-out in-none TYR APEdihe_nniai APEdist_aaai VOY Type1.5_Back 706 - 992 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 7JXHH 3.27 Inactive DFGin‑None out-out in-out TYR APEdihe_oiiai APEdist_aaai VOY Type1.5_Back 707 - 992 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 3PP0A 2.25 Inactive DFGin‑None out-out in-in TYR APEdihe_iiiai APEdist_aaai 03Q Type1.5_Back 706 - 993 0 None M706A,Q711L,M712L Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 3PP0B 2.25 Inactive DFGin‑None out-out in-out TYR APEdihe_oiiai APEdist_aaai 03Q Type1.5_Back 706 - 1009 0 None M706A,Q711L,M712L Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 3RCDA 3.21 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 03P Type1.5_Back 713 - 1022 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 3RCDC 3.21 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 03P Type1.5_Back 713 - 1022 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 8U8XA 1.69 Inactive DFGout‑None out-out out-out TYR APEdihe_iiiai APEdist_aaao W9N Type1 712 - 1024 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
ERBB2_HUMAN 8VB5A 1.48 Inactive None‑None out-out out-out TYR APEdihe_iiiai APEdist_aaao A1AAC Type1 706 - 990 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens

TYR_ERBB2 (Receptor tyrosine-protein kinase erbB-2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism