TYR_ERBB2 (Receptor tyrosine-protein kinase erbB-2)

Total number of chains: 19
Active chains: 2
Uniprot: ERBB2_HUMAN
Kinase Domain Residues: 720 - 978
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 10 52.6% 3PP0A
DFGin BLAminus 4 21.1% AF-P04626-K1A
DFGin BLBminus 2 10.5% 7PCDA
DFGin BLBplus 1 5.3% 7JXHE
DFGout None 1 5.3% 8U8XA
None None 1 5.3% 8VB5A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ERBB2 AF-P04626-K1A P04626 712 986 1255.0 No_ligand No_ligand Active DFGin 6.5639 14.0171 BLAminus -144.66, -176.12 61.8, 62.85 -78.34, 15.78 291.35, 91.75 -63.64, -22.88 in-in in 8.945 Saltbr-in 2.7188 HRD-in -76.17, -43.33 68.24, -14.48 in-in-in SNCiii in-in ActLoopNT-in 2.8437 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.2, 132.85 APE9-dihe-in -133.68, 146.19 APE8-dihe-in -82.15, 71.71 APE8-rot-na 35.76 APE67-dihe-in -70.12, -10.82 -41.93, -41.36 APE12-dist-na 11.3675 APE11-dist-na 9.7059 APE10-dist-na 10.5198 APE9-dist-in 6.6372 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 30 30 0 [[720, 978]] 1.0 AF-P04626-K1 TYR_ERBB2_HUMAN TYR 4.1e-86 294.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 AF-P04626-K3A P04626 712 986 1255.0 No_ligand No_ligand Active DFGin 6.1285 14.6813 BLAminus -146.79, -169.62 57.65, 68.57 -82.73, 14.22 294.24, 97.83 -60.74, -26.87 in-in in 8.8948 Saltbr-in 2.725 HRD-in -80.22, -44.01 67.05, -11.61 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.14, 131.07 APE9-dihe-in -137.06, 151.46 APE8-dihe-in -81.74, 64.34 APE8-rot-na 38.16 APE67-dihe-in -68.22, -12.83 -42.92, -40.11 APE12-dist-na 11.3414 APE11-dist-na 9.5334 APE10-dist-na 9.9419 APE9-dist-in 6.1805 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 30 30 0 [[720, 978]] 1.0 AF-P04626-K3 TYR_ERBB2_HUMAN TYR 4.1e-86 294.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 3RCDB P04626 713 1010 1255.0 No_ligand No_ligand Inactive DFGin 7.2562 11.5226 BLAminus -162.6, -165.98 69.09, 34.02 -51.41, 70.59 347.73, 81.5 31.46, 999.0 out-out out 13.7947 Saltbr-out 12.0493 HRD-in -50.78, -58.3 87.17, -54.04 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -57.16 APE8-dihe-in -79.63, 85.56 APE8-rot-na 30.88 APE67-dihe-in -73.13, -19.0 -76.27, -37.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.4587 None None None XRAY 3.21 0.227 0.294 B 338.0 268.0 22 30 12 18 [[720, 978]] 1.0 3rcd TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 3RCDD P04626 713 1010 1255.0 No_ligand No_ligand Inactive DFGin 7.2379 11.4943 BLAminus -162.12, -166.04 68.93, 33.06 -50.02, 70.36 348.11, 80.81 32.92, 999.0 out-out out 13.8024 Saltbr-out 12.0259 HRD-in -49.69, -57.8 88.91, -54.81 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -58.76 APE8-dihe-in -79.29, 85.84 APE8-rot-na 29.28 APE67-dihe-in -73.16, -18.62 -76.57, -38.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.542 None None None XRAY 3.21 0.227 0.294 D 338.0 268.0 22 30 12 18 [[720, 978]] 1.0 3rcd TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 7PCDA P04626 710 991 1255.0 70I:1101 Type1.5_Back Inactive DFGin 8.3829 13.2036 BLBminus -148.41, -166.41 62.56, 52.18 -68.49, 124.41 307.97, 99.05 -75.96, 149.37 out-out out 12.8979 Saltbr-out 9.9353 HRD-in -70.48, -51.68 76.42, -1.85 out-out-none SNCoon out-none ActLoopNT-out 12.4756 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 150.12 APE8-dihe-in -82.11, 73.84 APE8-rot-na 35.94 APE67-dihe-in -73.1, -9.91 -54.31, -42.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7239 None None None XRAY 1.77 0.21 0.241 A 327.0 272.0 10 30 20 10 [[720, 978]] 1.0 7pcd TYR_ERBB2_HUMAN TYR 7.6e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 7JXHA P04626 706 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 5.9081 13.2398 BLBminus -131.52, 175.2 62.08, 56.13 -92.48, -170.68 344.14, 107.37 58.36, 33.43 out-out out 13.0279 Saltbr-out 9.6096 HRD-in -57.73, -60.36 83.58, -8.59 out-out-out SNCooo out-out ActLoopNT-out 8.5337 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.53 APE8-dihe-in -82.79, 85.07 APE8-rot-na 32.34 APE67-dihe-in -86.46, -6.53 -76.67, -19.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0952 None None None XRAY 3.27 0.241 0.285 A 326.0 272.0 15 30 15 15 [[720, 978]] 1.0 7jxh TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 7JXHE P04626 709 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 5.506 13.0298 BLBplus -144.25, 173.09 68.0, 35.8 -95.14, 154.97 35.11, 54.15 82.38, 22.11 out-out out 12.3662 Saltbr-out 8.7511 HRD-in -57.84, -60.65 83.01, -1.74 out-out-none SNCoon out-none ActLoopNT-out 9.2122 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 58.84 APE8-rot-na 31.63 APE67-dihe-in -82.19, -4.4 -74.83, -20.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 3.27 0.241 0.285 E 326.0 268.0 16 30 14 16 [[720, 978]] 1.0 7jxh TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 7JXHB P04626 707 996 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 7.2065 13.5254 None -148.36, -162.08 75.74, -80.61 60.69, 10.97 304.93, 117.3 -60.45, -19.03 out-out out 11.1459 Saltbr-out 7.1946 HRD-in -68.76, -43.51 73.16, -15.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.14, 8.4 APE9-dihe-in -91.45, 135.42 APE8-dihe-in -59.93, 122.28 APE8-rot-na 333.95 APE67-dihe-in -83.25, -7.59 -73.08, -19.15 APE12-dist-na 999.0 APE11-dist-na 10.876 APE10-dist-na 7.7989 APE9-dist-in 5.3721 None None None XRAY 3.27 0.241 0.285 B 326.0 276.0 14 30 16 14 [[720, 978]] 1.0 7jxh TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 7JXHC P04626 707 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.6125 13.3041 None -143.65, -158.56 73.24, -76.65 56.5, 17.37 306.61, 100.9 -65.36, -26.15 out-out out 11.167 Saltbr-out 8.5521 HRD-in -71.63, -45.71 67.47, -11.62 out-in-out SNCoio in-out ActLoopNT-in 2.8423 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -101.65, -5.59 APE9-dihe-in -76.55, 128.34 APE8-dihe-in -57.68, 119.14 APE8-rot-na 333.73 APE67-dihe-in -84.4, -5.28 -70.79, -17.96 APE12-dist-na 999.0 APE11-dist-na 10.8294 APE10-dist-na 7.7009 APE9-dist-in 5.3788 None None None XRAY 3.27 0.241 0.285 C 326.0 274.0 12 30 18 12 [[720, 978]] 1.0 7jxh TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 7JXHD P04626 707 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.7679 13.3927 None -142.96, -159.37 73.71, -79.68 58.36, 17.86 306.67, 100.24 -64.62, -26.72 out-out out 11.1303 Saltbr-out 5.9863 HRD-in -71.8, -45.74 66.79, -11.56 out-in-none SNCoin in-none ActLoopNT-in 3.0535 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 8.73 APE9-dihe-in -87.17, 130.9 APE8-dihe-in -61.26, 114.35 APE8-rot-na 332.97 APE67-dihe-in -82.22, -4.18 -69.93, -17.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.7783 APE9-dist-in 5.5184 None None None XRAY 3.27 0.241 0.285 D 326.0 283.0 3 30 27 3 [[720, 978]] 1.0 7jxh TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 7JXHF P04626 713 991 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.9028 13.9624 None -147.07, -162.69 78.08, -83.21 56.45, 8.27 300.93, 121.19 -58.9, -10.87 out-out out 10.8692 Saltbr-out 6.7281 HRD-in -63.37, -44.43 70.8, -16.12 out-out-none SNCoon out-none ActLoopNT-out 5.435 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.37 APE8-dihe-in -63.96, 121.3 APE8-rot-na 334.12 APE67-dihe-in -82.97, -7.43 -74.51, -19.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.6423 None None None XRAY 3.27 0.241 0.285 F 326.0 262.0 17 30 18 12 [[720, 978]] 1.0 7jxh TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 7JXHG P04626 706 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 7.8697 13.8089 None -142.75, -163.19 75.45, -91.2 64.27, 18.94 302.94, 97.25 -68.06, -26.16 out-out out 11.5789 Saltbr-out 7.4558 HRD-in -69.52, -47.34 66.45, -11.89 out-in-none SNCoin in-none ActLoopNT-in 3.4707 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.01 APE8-dihe-in -53.01, 109.02 APE8-rot-na 332.56 APE67-dihe-in -83.03, -4.37 -69.53, -16.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.7907 None None None XRAY 3.27 0.241 0.285 G 326.0 273.0 14 30 16 14 [[720, 978]] 1.0 7jxh TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 7JXHH P04626 707 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.4919 13.3909 None -147.0, -168.64 78.92, -65.16 55.44, -120.37 308.82, 110.24 77.15, -59.63 out-out out 10.4414 Saltbr-out 6.2345 HRD-in -70.56, -45.63 67.17, -12.43 out-in-out SNCoio in-out ActLoopNT-in 2.8816 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.87, 9.88 APE9-dihe-in -95.76, 115.55 APE8-dihe-in -50.25, 109.35 APE8-rot-na 333.22 APE67-dihe-in -82.18, -3.91 -69.96, -16.92 APE12-dist-na 8.8114 APE11-dist-na 10.9517 APE10-dist-na 7.599 APE9-dist-in 5.5459 None None None XRAY 3.27 0.241 0.285 H 326.0 282.0 4 30 30 0 [[720, 978]] 1.0 7jxh TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 3PP0A P04626 706 993 1255.0 03Q:1 Type1.5_Back Inactive DFGin 6.1891 12.8909 None -143.24, -161.48 74.0, -72.25 62.71, 12.18 304.07, 105.53 -53.57, -26.07 out-out out 10.8314 Saltbr-out 6.7356 HRD-in -72.52, -43.75 67.05, -6.56 out-in-in SNCoii in-in ActLoopNT-in 2.986 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.93, 133.73 APE9-dihe-in -132.61, 148.93 APE8-dihe-in -81.51, 83.41 APE8-rot-na 32.02 APE67-dihe-in -73.68, -2.45 -53.16, -44.04 APE12-dist-na 999.0 APE11-dist-na 9.4866 APE10-dist-na 9.955 APE9-dist-in 6.4533 M706A,Q711L,M712L None None XRAY 2.25 0.189 0.26 A 338.0 286.0 2 30 28 2 [[720, 978]] 1.0 3pp0 TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 3PP0B P04626 706 1009 1255.0 03Q:2 Type1.5_Back Inactive DFGin 6.5295 13.1712 None -149.09, -166.81 85.39, -78.34 67.1, 11.91 301.66, 109.6 -51.94, -39.66 out-out out 10.6441 Saltbr-out 6.7399 HRD-in -69.4, -53.62 79.07, -10.52 out-in-out SNCoio in-out ActLoopNT-in 2.8388 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.46, -6.75 APE9-dihe-in -77.94, 120.44 APE8-dihe-in -61.24, 120.47 APE8-rot-na 332.74 APE67-dihe-in -74.13, -7.61 -67.24, -26.94 APE12-dist-na 999.0 APE11-dist-na 10.6587 APE10-dist-na 7.6218 APE9-dist-in 5.3485 M706A,Q711L,M712L None None XRAY 2.25 0.189 0.26 B 338.0 296.0 2 30 28 2 [[720, 978]] 1.0 3pp0 TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 3RCDA P04626 713 1022 1255.0 03P:69001 Type1.5_Back Inactive DFGin 7.3275 12.7836 None -131.6, -178.33 92.87, -78.83 17.87, 80.88 36.71, 96.9 175.62, 84.65 out-out out 12.7748 Saltbr-out 10.1037 HRD-in -81.36, -50.25 83.34, -29.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 32.08 APE8-dihe-in -80.8, 92.84 APE8-rot-na 32.85 APE67-dihe-in -72.62, -9.61 -71.44, -35.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.7735 None None None XRAY 3.21 0.227 0.294 A 338.0 278.0 21 30 13 17 [[720, 978]] 1.0 3rcd TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 3RCDC P04626 713 1022 1255.0 03P:69001 Type1.5_Back Inactive DFGin 7.2988 12.8076 None -129.48, -177.14 93.53, -78.44 17.53, 81.66 36.39, 96.61 174.11, 84.1 out-out out 12.7623 Saltbr-out 10.1811 HRD-in -79.56, -52.25 82.81, -26.53 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 30.75 APE8-dihe-in -78.7, 91.19 APE8-rot-na 32.27 APE67-dihe-in -71.69, -11.86 -69.94, -35.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.6837 None None None XRAY 3.21 0.227 0.294 C 338.0 278.0 21 30 13 17 [[720, 978]] 1.0 3rcd TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 8U8XA P04626 712 1024 1255.0 W9N:61101 Type1 Inactive DFGout 13.4821 13.3336 None -129.81, 177.67 64.69, 73.23 -147.25, 162.07 53.54, 85.09 97.47, -6.1 out-out out 16.0555 Saltbr-out 20.3039 HRD-in -74.04, -54.22 80.88, -6.76 out-out-out SNCooo out-out ActLoopNT-out 7.1333 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -87.32, 128.38 APE9-dihe-in -138.84, 154.99 APE8-dihe-in -82.3, 65.4 APE8-rot-na 28.41 APE67-dihe-in -77.12, -2.98 -53.37, -41.06 APE12-dist-na 16.8573 APE11-dist-na 16.6275 APE10-dist-na 15.8589 APE9-dist-out 8.1708 None None None XRAY 1.69 0.166 0.203 A 348.0 304.0 2 30 30 0 [[720, 978]] 1.0 8u8x TYR_ERBB2_HUMAN TYR 8.9e-84 286.8 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 8VB5A P04626 706 990 1255.0 A1AAC:61101 Type1 Inactive None 999.0 13.127 None -138.51, 178.96 59.5, 31.82 -81.44, 146.92 46.7, 89.0 57.03, 36.14 out-out out 13.5823 Saltbr-out 11.2898 HRD-in -68.6, -58.45 82.76, -10.58 out-out-out SNCooo out-out ActLoopNT-out 9.6563 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -78.45, 136.82 APE9-dihe-in -65.23, 128.82 APE8-dihe-in -78.23, 60.2 APE8-rot-na 33.2 APE67-dihe-in -78.8, -4.76 -48.22, -40.86 APE12-dist-na 12.4386 APE11-dist-na 13.1039 APE10-dist-na 15.3619 APE9-dist-out 9.0113 None None None XRAY 1.48 0.147 0.187 A 342.0 285.0 0 30 30 0 [[720, 978]] 1.0 8vb5 TYR_ERBB2_HUMAN TYR 8.4e-84 286.9 2.0 260.0 259.0 862 863 864 866 868 753 770 -9999 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2

TYR_ERBB2 (Receptor tyrosine-protein kinase erbB-2)

Total number of chains: 19
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 10 52.6% 3PP0A
DFGin BLAminus 4 21.1% AF-P04626-K1A
DFGin BLBminus 2 10.5% 7PCDA
DFGin BLBplus 1 5.3% 7JXHE
DFGout None 1 5.3% 8U8XA
None None 1 5.3% 8VB5A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ERBB2 ERBB2_HUMAN AF-P04626-K1A P04626 712 986 1255.0 No_ligand No_ligand Active DFGin 6.5639 14.0171 BLAminus -144.66, -176.12 61.8, 62.85 -78.34, 15.78 291.35, 91.75 -63.64, -22.88 in-in in 8.945 Saltbr-in 2.7188 HRD-in -76.17, -43.33 68.24, -14.48 in-in-in SNCiii in-in ActLoopNT-in 2.8437 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.2, 132.85 APE9-dihe-in -133.68, 146.19 APE8-dihe-in -82.15, 71.71 APE8-rot-na 35.76 APE67-dihe-in -70.12, -10.82 -41.93, -41.36 APE12-dist-na 11.3675 APE11-dist-na 9.7059 APE10-dist-na 10.5198 APE9-dist-in 6.6372 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 30 30 0 [[720, 978]] 1.0 AF-P04626-K1 Homo sapiens TYR_ERBB2_HUMAN TYR 4.1e-86 294.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN AF-P04626-K3A P04626 712 986 1255.0 No_ligand No_ligand Active DFGin 6.1285 14.6813 BLAminus -146.79, -169.62 57.65, 68.57 -82.73, 14.22 294.24, 97.83 -60.74, -26.87 in-in in 8.8948 Saltbr-in 2.725 HRD-in -80.22, -44.01 67.05, -11.61 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.14, 131.07 APE9-dihe-in -137.06, 151.46 APE8-dihe-in -81.74, 64.34 APE8-rot-na 38.16 APE67-dihe-in -68.22, -12.83 -42.92, -40.11 APE12-dist-na 11.3414 APE11-dist-na 9.5334 APE10-dist-na 9.9419 APE9-dist-in 6.1805 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 30 30 0 [[720, 978]] 1.0 AF-P04626-K3 Homo sapiens TYR_ERBB2_HUMAN TYR 4.1e-86 294.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 3RCDB P04626 713 1010 1255.0 No_ligand No_ligand Inactive DFGin 7.2562 11.5226 BLAminus -162.6, -165.98 69.09, 34.02 -51.41, 70.59 347.73, 81.5 31.46, 999.0 out-out out 13.7947 Saltbr-out 12.0493 HRD-in -50.78, -58.3 87.17, -54.04 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -57.16 APE8-dihe-in -79.63, 85.56 APE8-rot-na 30.88 APE67-dihe-in -73.13, -19.0 -76.27, -37.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.4587 None None None XRAY 3.21 0.227 0.294 B 338.0 268.0 22 30 12 18 [[720, 978]] 1.0 3rcd Homo sapiens TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 3RCDD P04626 713 1010 1255.0 No_ligand No_ligand Inactive DFGin 7.2379 11.4943 BLAminus -162.12, -166.04 68.93, 33.06 -50.02, 70.36 348.11, 80.81 32.92, 999.0 out-out out 13.8024 Saltbr-out 12.0259 HRD-in -49.69, -57.8 88.91, -54.81 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -58.76 APE8-dihe-in -79.29, 85.84 APE8-rot-na 29.28 APE67-dihe-in -73.16, -18.62 -76.57, -38.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.542 None None None XRAY 3.21 0.227 0.294 D 338.0 268.0 22 30 12 18 [[720, 978]] 1.0 3rcd Homo sapiens TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 7PCDA P04626 710 991 1255.0 70I:1101 Type1.5_Back Inactive DFGin 8.3829 13.2036 BLBminus -148.41, -166.41 62.56, 52.18 -68.49, 124.41 307.97, 99.05 -75.96, 149.37 out-out out 12.8979 Saltbr-out 9.9353 HRD-in -70.48, -51.68 76.42, -1.85 out-out-none SNCoon out-none ActLoopNT-out 12.4756 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 150.12 APE8-dihe-in -82.11, 73.84 APE8-rot-na 35.94 APE67-dihe-in -73.1, -9.91 -54.31, -42.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7239 None None None XRAY 1.77 0.21 0.241 A 327.0 272.0 10 30 20 10 [[720, 978]] 1.0 7pcd Homo sapiens TYR_ERBB2_HUMAN TYR 7.6e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 7JXHA P04626 706 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 5.9081 13.2398 BLBminus -131.52, 175.2 62.08, 56.13 -92.48, -170.68 344.14, 107.37 58.36, 33.43 out-out out 13.0279 Saltbr-out 9.6096 HRD-in -57.73, -60.36 83.58, -8.59 out-out-out SNCooo out-out ActLoopNT-out 8.5337 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.53 APE8-dihe-in -82.79, 85.07 APE8-rot-na 32.34 APE67-dihe-in -86.46, -6.53 -76.67, -19.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0952 None None None XRAY 3.27 0.241 0.285 A 326.0 272.0 15 30 15 15 [[720, 978]] 1.0 7jxh Homo sapiens TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 7JXHE P04626 709 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 5.506 13.0298 BLBplus -144.25, 173.09 68.0, 35.8 -95.14, 154.97 35.11, 54.15 82.38, 22.11 out-out out 12.3662 Saltbr-out 8.7511 HRD-in -57.84, -60.65 83.01, -1.74 out-out-none SNCoon out-none ActLoopNT-out 9.2122 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 58.84 APE8-rot-na 31.63 APE67-dihe-in -82.19, -4.4 -74.83, -20.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 3.27 0.241 0.285 E 326.0 268.0 16 30 14 16 [[720, 978]] 1.0 7jxh Homo sapiens TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 7JXHB P04626 707 996 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 7.2065 13.5254 None -148.36, -162.08 75.74, -80.61 60.69, 10.97 304.93, 117.3 -60.45, -19.03 out-out out 11.1459 Saltbr-out 7.1946 HRD-in -68.76, -43.51 73.16, -15.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.14, 8.4 APE9-dihe-in -91.45, 135.42 APE8-dihe-in -59.93, 122.28 APE8-rot-na 333.95 APE67-dihe-in -83.25, -7.59 -73.08, -19.15 APE12-dist-na 999.0 APE11-dist-na 10.876 APE10-dist-na 7.7989 APE9-dist-in 5.3721 None None None XRAY 3.27 0.241 0.285 B 326.0 276.0 14 30 16 14 [[720, 978]] 1.0 7jxh Homo sapiens TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 7JXHC P04626 707 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.6125 13.3041 None -143.65, -158.56 73.24, -76.65 56.5, 17.37 306.61, 100.9 -65.36, -26.15 out-out out 11.167 Saltbr-out 8.5521 HRD-in -71.63, -45.71 67.47, -11.62 out-in-out SNCoio in-out ActLoopNT-in 2.8423 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -101.65, -5.59 APE9-dihe-in -76.55, 128.34 APE8-dihe-in -57.68, 119.14 APE8-rot-na 333.73 APE67-dihe-in -84.4, -5.28 -70.79, -17.96 APE12-dist-na 999.0 APE11-dist-na 10.8294 APE10-dist-na 7.7009 APE9-dist-in 5.3788 None None None XRAY 3.27 0.241 0.285 C 326.0 274.0 12 30 18 12 [[720, 978]] 1.0 7jxh Homo sapiens TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 7JXHD P04626 707 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.7679 13.3927 None -142.96, -159.37 73.71, -79.68 58.36, 17.86 306.67, 100.24 -64.62, -26.72 out-out out 11.1303 Saltbr-out 5.9863 HRD-in -71.8, -45.74 66.79, -11.56 out-in-none SNCoin in-none ActLoopNT-in 3.0535 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 8.73 APE9-dihe-in -87.17, 130.9 APE8-dihe-in -61.26, 114.35 APE8-rot-na 332.97 APE67-dihe-in -82.22, -4.18 -69.93, -17.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.7783 APE9-dist-in 5.5184 None None None XRAY 3.27 0.241 0.285 D 326.0 283.0 3 30 27 3 [[720, 978]] 1.0 7jxh Homo sapiens TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 7JXHF P04626 713 991 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.9028 13.9624 None -147.07, -162.69 78.08, -83.21 56.45, 8.27 300.93, 121.19 -58.9, -10.87 out-out out 10.8692 Saltbr-out 6.7281 HRD-in -63.37, -44.43 70.8, -16.12 out-out-none SNCoon out-none ActLoopNT-out 5.435 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.37 APE8-dihe-in -63.96, 121.3 APE8-rot-na 334.12 APE67-dihe-in -82.97, -7.43 -74.51, -19.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.6423 None None None XRAY 3.27 0.241 0.285 F 326.0 262.0 17 30 18 12 [[720, 978]] 1.0 7jxh Homo sapiens TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 7JXHG P04626 706 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 7.8697 13.8089 None -142.75, -163.19 75.45, -91.2 64.27, 18.94 302.94, 97.25 -68.06, -26.16 out-out out 11.5789 Saltbr-out 7.4558 HRD-in -69.52, -47.34 66.45, -11.89 out-in-none SNCoin in-none ActLoopNT-in 3.4707 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.01 APE8-dihe-in -53.01, 109.02 APE8-rot-na 332.56 APE67-dihe-in -83.03, -4.37 -69.53, -16.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.7907 None None None XRAY 3.27 0.241 0.285 G 326.0 273.0 14 30 16 14 [[720, 978]] 1.0 7jxh Homo sapiens TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 7JXHH P04626 707 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.4919 13.3909 None -147.0, -168.64 78.92, -65.16 55.44, -120.37 308.82, 110.24 77.15, -59.63 out-out out 10.4414 Saltbr-out 6.2345 HRD-in -70.56, -45.63 67.17, -12.43 out-in-out SNCoio in-out ActLoopNT-in 2.8816 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.87, 9.88 APE9-dihe-in -95.76, 115.55 APE8-dihe-in -50.25, 109.35 APE8-rot-na 333.22 APE67-dihe-in -82.18, -3.91 -69.96, -16.92 APE12-dist-na 8.8114 APE11-dist-na 10.9517 APE10-dist-na 7.599 APE9-dist-in 5.5459 None None None XRAY 3.27 0.241 0.285 H 326.0 282.0 4 30 30 0 [[720, 978]] 1.0 7jxh Homo sapiens TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 3PP0A P04626 706 993 1255.0 03Q:1 Type1.5_Back Inactive DFGin 6.1891 12.8909 None -143.24, -161.48 74.0, -72.25 62.71, 12.18 304.07, 105.53 -53.57, -26.07 out-out out 10.8314 Saltbr-out 6.7356 HRD-in -72.52, -43.75 67.05, -6.56 out-in-in SNCoii in-in ActLoopNT-in 2.986 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.93, 133.73 APE9-dihe-in -132.61, 148.93 APE8-dihe-in -81.51, 83.41 APE8-rot-na 32.02 APE67-dihe-in -73.68, -2.45 -53.16, -44.04 APE12-dist-na 999.0 APE11-dist-na 9.4866 APE10-dist-na 9.955 APE9-dist-in 6.4533 M706A,Q711L,M712L None None XRAY 2.25 0.189 0.26 A 338.0 286.0 2 30 28 2 [[720, 978]] 1.0 3pp0 Homo sapiens TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 3PP0B P04626 706 1009 1255.0 03Q:2 Type1.5_Back Inactive DFGin 6.5295 13.1712 None -149.09, -166.81 85.39, -78.34 67.1, 11.91 301.66, 109.6 -51.94, -39.66 out-out out 10.6441 Saltbr-out 6.7399 HRD-in -69.4, -53.62 79.07, -10.52 out-in-out SNCoio in-out ActLoopNT-in 2.8388 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.46, -6.75 APE9-dihe-in -77.94, 120.44 APE8-dihe-in -61.24, 120.47 APE8-rot-na 332.74 APE67-dihe-in -74.13, -7.61 -67.24, -26.94 APE12-dist-na 999.0 APE11-dist-na 10.6587 APE10-dist-na 7.6218 APE9-dist-in 5.3485 M706A,Q711L,M712L None None XRAY 2.25 0.189 0.26 B 338.0 296.0 2 30 28 2 [[720, 978]] 1.0 3pp0 Homo sapiens TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 3RCDA P04626 713 1022 1255.0 03P:69001 Type1.5_Back Inactive DFGin 7.3275 12.7836 None -131.6, -178.33 92.87, -78.83 17.87, 80.88 36.71, 96.9 175.62, 84.65 out-out out 12.7748 Saltbr-out 10.1037 HRD-in -81.36, -50.25 83.34, -29.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 32.08 APE8-dihe-in -80.8, 92.84 APE8-rot-na 32.85 APE67-dihe-in -72.62, -9.61 -71.44, -35.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.7735 None None None XRAY 3.21 0.227 0.294 A 338.0 278.0 21 30 13 17 [[720, 978]] 1.0 3rcd Homo sapiens TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 3RCDC P04626 713 1022 1255.0 03P:69001 Type1.5_Back Inactive DFGin 7.2988 12.8076 None -129.48, -177.14 93.53, -78.44 17.53, 81.66 36.39, 96.61 174.11, 84.1 out-out out 12.7623 Saltbr-out 10.1811 HRD-in -79.56, -52.25 82.81, -26.53 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 30.75 APE8-dihe-in -78.7, 91.19 APE8-rot-na 32.27 APE67-dihe-in -71.69, -11.86 -69.94, -35.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.6837 None None None XRAY 3.21 0.227 0.294 C 338.0 278.0 21 30 13 17 [[720, 978]] 1.0 3rcd Homo sapiens TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 8U8XA P04626 712 1024 1255.0 W9N:61101 Type1 Inactive DFGout 13.4821 13.3336 None -129.81, 177.67 64.69, 73.23 -147.25, 162.07 53.54, 85.09 97.47, -6.1 out-out out 16.0555 Saltbr-out 20.3039 HRD-in -74.04, -54.22 80.88, -6.76 out-out-out SNCooo out-out ActLoopNT-out 7.1333 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -87.32, 128.38 APE9-dihe-in -138.84, 154.99 APE8-dihe-in -82.3, 65.4 APE8-rot-na 28.41 APE67-dihe-in -77.12, -2.98 -53.37, -41.06 APE12-dist-na 16.8573 APE11-dist-na 16.6275 APE10-dist-na 15.8589 APE9-dist-out 8.1708 None None None XRAY 1.69 0.166 0.203 A 348.0 304.0 2 30 30 0 [[720, 978]] 1.0 8u8x Homo sapiens TYR_ERBB2_HUMAN TYR 8.9e-84 286.8 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
ERBB2 ERBB2_HUMAN 8VB5A P04626 706 990 1255.0 A1AAC:61101 Type1 Inactive None 999.0 13.127 None -138.51, 178.96 59.5, 31.82 -81.44, 146.92 46.7, 89.0 57.03, 36.14 out-out out 13.5823 Saltbr-out 11.2898 HRD-in -68.6, -58.45 82.76, -10.58 out-out-out SNCooo out-out ActLoopNT-out 9.6563 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -78.45, 136.82 APE9-dihe-in -65.23, 128.82 APE8-dihe-in -78.23, 60.2 APE8-rot-na 33.2 APE67-dihe-in -78.8, -4.76 -48.22, -40.86 APE12-dist-na 12.4386 APE11-dist-na 13.1039 APE10-dist-na 15.3619 APE9-dist-out 9.0113 None None None XRAY 1.48 0.147 0.187 A 342.0 285.0 0 30 30 0 [[720, 978]] 1.0 8vb5 Homo sapiens TYR_ERBB2_HUMAN TYR 8.4e-84 286.9 2.0 260.0 259.0 862 863 864 866 868 753 770 -9999 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2

TYR_ERBB2 (Receptor tyrosine-protein kinase erbB-2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name