TYR_EPHB4 (Ephrin type-B receptor 4)

Total number of chains: 24
Active chains: 2
Uniprot: EPHB4_HUMAN
Kinase Domain Residues: 615 - 876
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 11 45.8% 2VWXA
DFGin BLAminus 5 20.8% AF-P54760-K1A
DFGin None 5 20.8% 2YN8B
DFGout BBAminus 3 12.5% 6FNJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P54760-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 607 - 884 0 None None Ephrin type-B receptor 4
AF-P54760-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 607 - 884 0 None None Ephrin type-B receptor 4
6FNKA 1.049 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai DXK Type1 604 - 889 0 None Y774E,A803V,V870I Ephrin type-B receptor 4
6FNMA 1.157 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1 608 - 889 0 None Y774E,A803V,V870I Ephrin type-B receptor 4
4AW5A 2.33 Inactive DFGin‑BLBminus in-in none-none TYR APEdihe_nniai APEdist_aaai 30K Type1 607 - 888 0 None None Ephrin type-B receptor 4
2VWXA 1.65 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 7X4 Type1 608 - 888 0 None Y774E Ephrin type-B receptor 4
2VWYA 1.65 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 7X5 Type1 608 - 888 0 None Y774E Ephrin type-B receptor 4
2VWZA 1.65 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 7X6 Type1 608 - 888 0 None Y774E Ephrin type-B receptor 4
2VX0A 2.1 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 7X7 Type1 608 - 888 0 None Y774E Ephrin type-B receptor 4
2VX1A 1.65 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 7X8 Type1 608 - 888 0 None Y774E Ephrin type-B receptor 4
2X9FA 1.75 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai X9F Type1 608 - 888 0 None Y774E Ephrin type-B receptor 4
4BB4A 1.65 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 32W Type1 606 - 888 0 None Y774E Ephrin type-B receptor 4
2XVDA 1.7 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai AS6 Type1.5_Back 607 - 888 0 None Y774E Ephrin type-B receptor 4
2YN8A 2.11 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 608 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4
2YN8B 2.11 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 606 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4
2VWUA 2.0 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai 7X1 Type1 609 - 887 0 None Y774E Ephrin type-B receptor 4
2VWVA 1.9 Inactive DFGin‑None in-in none-none TYR APEdihe_niiai APEdist_aaai 7X3 Type1 606 - 885 0 None Y774E Ephrin type-B receptor 4
2VWWA 1.9 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai 7X2 Type1 609 - 887 0 None Y774E Ephrin type-B receptor 4
6FNIA 1.468 Inactive DFGout‑BBAminus in-in out-out TYR APEdihe_nniai APEdist_aaao DXH Type2 607 - 889 0 None Y774E,A803V,V870I Ephrin type-B receptor 4
6FNJA 1.239 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_nnoai APEdist_aaao DWT Type2 607 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4
6FNJB 1.239 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_nnoai APEdist_aaao DWT Type2 607 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4
6FNLA 1.269 None DFGin‑BLAminus in-in none-none TYR APEdihe_niiai APEdist_aaai No_ligand No_ligand 607 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4
3ZEWA 2.5 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai STU Type1 609 - 888 0 PTR774 None Ephrin type-B receptor 4
3ZEWB 2.5 None DFGin‑BLAminus in-none none-none TYR APEdihe_nniai APEdist_aaai STU Type1 609 - 887 0 PTR774 None Ephrin type-B receptor 4

TYR_EPHB4 (Ephrin type-B receptor 4)

Total number of chains: 24
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 11 45.8% 2VWXA
DFGin BLAminus 5 20.8% AF-P54760-K1A
DFGin None 5 20.8% 2YN8B
DFGout BBAminus 3 12.5% 6FNJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
EPHB4_HUMAN AF-P54760-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 607 - 884 0 None None Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN AF-P54760-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 607 - 884 0 None None Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 6FNKA 1.049 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai DXK Type1 604 - 889 0 None Y774E,A803V,V870I Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 6FNMA 1.157 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1 608 - 889 0 None Y774E,A803V,V870I Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 4AW5A 2.33 Inactive DFGin‑BLBminus in-in none-none TYR APEdihe_nniai APEdist_aaai 30K Type1 607 - 888 0 None None Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 2VWXA 1.65 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 7X4 Type1 608 - 888 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 2VWYA 1.65 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 7X5 Type1 608 - 888 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 2VWZA 1.65 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 7X6 Type1 608 - 888 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 2VX0A 2.1 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 7X7 Type1 608 - 888 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 2VX1A 1.65 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 7X8 Type1 608 - 888 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 2X9FA 1.75 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai X9F Type1 608 - 888 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 4BB4A 1.65 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 32W Type1 606 - 888 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 2XVDA 1.7 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai AS6 Type1.5_Back 607 - 888 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 2YN8A 2.11 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 608 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 2YN8B 2.11 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 606 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 2VWUA 2.0 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai 7X1 Type1 609 - 887 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 2VWVA 1.9 Inactive DFGin‑None in-in none-none TYR APEdihe_niiai APEdist_aaai 7X3 Type1 606 - 885 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 2VWWA 1.9 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai 7X2 Type1 609 - 887 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 6FNIA 1.468 Inactive DFGout‑BBAminus in-in out-out TYR APEdihe_nniai APEdist_aaao DXH Type2 607 - 889 0 None Y774E,A803V,V870I Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 6FNJA 1.239 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_nnoai APEdist_aaao DWT Type2 607 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 6FNJB 1.239 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_nnoai APEdist_aaao DWT Type2 607 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 6FNLA 1.269 None DFGin‑BLAminus in-in none-none TYR APEdihe_niiai APEdist_aaai No_ligand No_ligand 607 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 3ZEWA 2.5 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai STU Type1 609 - 888 0 PTR774 None Ephrin type-B receptor 4 Homo sapiens
EPHB4_HUMAN 3ZEWB 2.5 None DFGin‑BLAminus in-none none-none TYR APEdihe_nniai APEdist_aaai STU Type1 609 - 887 0 PTR774 None Ephrin type-B receptor 4 Homo sapiens

TYR_EPHB4 (Ephrin type-B receptor 4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism