TYR_EPHB4 (Ephrin type-B receptor 4)

Total number of chains: 24
Active chains: 2
Family: TYR
Uniprot: EPHB4_HUMAN
Kinase Domain Residues: 615 - 876
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 11 45.8% 2VWXA
DFGin BLAminus 5 20.8% AF-P54760-K1A
DFGin None 5 20.8% 2YN8B
DFGout BBAminus 3 12.5% 6FNJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P54760-K1A 607 884 987.0 No_ligand No_ligand Active DFGin 5.974 13.869 BLAminus -139.74, -179.4 64.18, 66.44 -86.68, 11.54 302.15, 96.73 -58.75, -33.49 in-in in 7.984 Saltbr-in 2.704 HRD-in -80.56, -43.43 66.67, -18.44 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.66, 132.17 APE9-dihe-in -122.16, 137.66 APE8-dihe-in -75.12, 84.65 APE8-rot-na 34.37 APE67-dihe-in -67.33, -22.06 -45.78, -45.95 APE12-dist-na 13.481 APE11-dist-na 9.813 APE10-dist-na 10.422 APE9-dist-in 6.359 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[615, 876]] 1.0 AF-P54760-K1 TYR_EPHB4_HUMAN TYR 2e-104 354.4 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
AF-P54760-K3A 607 884 987.0 No_ligand No_ligand Active DFGin 5.806 14.151 BLAminus -143.99, -175.54 62.87, 66.13 -83.54, 8.28 297.5, 100.05 -58.46, -33.53 in-in in 8.059 Saltbr-in 2.682 HRD-in -82.2, -47.78 67.39, -9.2 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.19, 139.12 APE9-dihe-in -138.81, 146.93 APE8-dihe-in -78.16, 77.82 APE8-rot-na 36.7 APE67-dihe-in -64.24, -26.99 -41.53, -46.33 APE12-dist-na 14.244 APE11-dist-na 10.465 APE10-dist-na 10.193 APE9-dist-in 5.985 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[615, 876]] 1.0 AF-P54760-K3 TYR_EPHB4_HUMAN TYR 2e-104 354.4 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
6FNKA 604 889 987.0 DXK:1001 Type1 Inactive DFGin 5.785 15.402 BLBminus -132.34, -179.48 79.05, 78.64 -110.02, 142.82 291.49, 104.76 170.31, 139.89 in-in in 8.072 Saltbr-in 2.873 HRD-in -75.87, -49.11 78.1, -14.8 in-out-in SNCioi out-in ActLoopNT-out 9.893 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.14, 155.16 APE9-dihe-in -55.72, 125.74 APE8-dihe-in -77.88, 85.95 APE8-rot-na 29.38 APE67-dihe-in -64.24, -19.7 -51.66, -47.73 APE12-dist-na 999.0 APE11-dist-na 11.556 APE10-dist-na 14.982 APE9-dist-in 6.416 Y774E,A803V,V870I None None XRAY 1.049 0.196 0.22 A 297 274 12 0 0 12 [[615, 876]] 1.0 6fnk TYR_EPHB4_HUMAN TYR 4.2e-105 356.7 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
6FNMA 608 889 987.0 1N1:1001 Type1 Inactive DFGin 5.961 15.769 BLBminus -128.55, -169.2 67.78, 75.65 -110.02, 138.75 293.26, 98.41 179.12, 146.16 in-in in 8.325 Saltbr-in 3.179 HRD-in -76.03, -51.54 81.54, -15.45 in-out-in SNCioi out-in ActLoopNT-out 10.01 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.65, 157.69 APE9-dihe-in -64.87, 128.21 APE8-dihe-in -78.96, 90.14 APE8-rot-na 30.03 APE67-dihe-in -61.19, -22.58 -57.17, -48.0 APE12-dist-na 999.0 APE11-dist-na 11.368 APE10-dist-na 15.034 APE9-dist-in 6.576 Y774E,A803V,V870I None None XRAY 1.157 0.184 0.195 A 297 270 12 0 0 12 [[615, 876]] 1.0 6fnm TYR_EPHB4_HUMAN TYR 4.2e-105 356.7 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
4AW5A 607 888 987.0 30K:61365 Type1 Inactive DFGin 5.918 15.076 BLBminus -115.6, -155.32 63.85, 73.81 -110.34, -176.13 296.63, 113.1 132.46, 999.0 in-in in 7.859 Saltbr-in 3.091 HRD-in -70.15, -42.22 67.5, -11.8 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 143.07 APE8-dihe-in -82.91, 93.65 APE8-rot-na 28.44 APE67-dihe-in -75.4, -11.75 -51.64, -47.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6 None None None XRAY 2.33 0.194 0.279 A 291 261 21 0 0 21 [[615, 876]] 1.0 4aw5 TYR_EPHB4_HUMAN TYR 2.4e-104 354.2 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
2VWXA 608 888 987.0 7X4:1889 Type1 Inactive DFGin 6.062 15.525 BLBminus -131.7, 175.26 83.18, 89.55 -120.97, 136.17 291.75, 99.91 176.83, 144.38 in-in in 7.866 Saltbr-in 2.753 HRD-in -69.03, -53.3 76.5, -14.01 in-out-in SNCioi out-in ActLoopNT-out 9.88 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.19, 154.87 APE9-dihe-in -61.39, 127.49 APE8-dihe-in -75.6, 85.97 APE8-rot-na 30.31 APE67-dihe-in -62.78, -19.77 -52.09, -48.79 APE12-dist-na 7.566 APE11-dist-na 11.192 APE10-dist-na 14.742 APE9-dist-in 6.477 Y774E None None XRAY 1.65 0.168 0.209 A 302 274 7 0 0 7 [[615, 876]] 1.0 2vwx TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
2VWYA 608 888 987.0 7X5:1889 Type1 Inactive DFGin 5.975 15.314 BLBminus -130.24, 178.95 77.7, 88.46 -121.39, 135.89 295.36, 99.3 176.24, 150.88 in-in in 7.91 Saltbr-in 2.886 HRD-in -70.47, -50.81 79.51, -13.14 in-out-in SNCioi out-in ActLoopNT-out 10.037 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.43, 158.81 APE9-dihe-in -65.85, 132.14 APE8-dihe-in -80.12, 86.03 APE8-rot-na 32.28 APE67-dihe-in -63.92, -21.59 -53.89, -44.17 APE12-dist-na 7.375 APE11-dist-na 11.051 APE10-dist-na 14.672 APE9-dist-in 6.506 Y774E None None XRAY 1.65 0.19 0.238 A 302 274 7 0 0 7 [[615, 876]] 1.0 2vwy TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
2VWZA 608 888 987.0 7X6:1889 Type1 Inactive DFGin 5.998 15.385 BLBminus -131.74, 178.07 81.02, 89.07 -120.62, 135.23 292.73, 100.19 177.61, 146.72 in-in in 7.898 Saltbr-in 2.807 HRD-in -73.17, -49.73 76.87, -12.59 in-out-in SNCioi out-in ActLoopNT-out 9.963 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.02, 156.88 APE9-dihe-in -64.46, 130.34 APE8-dihe-in -77.08, 84.67 APE8-rot-na 29.41 APE67-dihe-in -69.47, -18.21 -49.97, -46.03 APE12-dist-na 7.524 APE11-dist-na 11.198 APE10-dist-na 14.848 APE9-dist-in 6.559 Y774E None None XRAY 1.65 0.17 0.205 A 302 274 7 0 0 7 [[615, 876]] 1.0 2vwz TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
2VX0A 608 888 987.0 7X7:1889 Type1 Inactive DFGin 6.056 15.407 BLBminus -143.81, 173.4 80.11, 86.54 -119.94, 137.85 294.49, 102.39 174.61, 145.02 in-in in 7.875 Saltbr-in 2.742 HRD-in -76.09, -48.2 78.58, -18.57 in-out-in SNCioi out-in ActLoopNT-out 10.28 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.92, 159.94 APE9-dihe-in -65.58, 131.65 APE8-dihe-in -77.85, 83.81 APE8-rot-na 31.95 APE67-dihe-in -65.25, -23.14 -49.53, -44.88 APE12-dist-na 999.0 APE11-dist-na 11.04 APE10-dist-na 14.741 APE9-dist-in 6.499 Y774E None None XRAY 2.1 0.187 0.233 A 302 273 8 0 0 8 [[615, 876]] 1.0 2vx0 TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
2VX1A 608 888 987.0 7X8:1889 Type1 Inactive DFGin 5.991 15.42 BLBminus -129.17, 177.79 80.46, 88.46 -119.62, 136.3 293.32, 97.76 177.93, 147.99 in-in in 7.915 Saltbr-in 2.817 HRD-in -72.22, -48.58 77.96, -12.84 in-out-in SNCioi out-in ActLoopNT-out 9.968 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.61, 154.3 APE9-dihe-in -59.44, 127.59 APE8-dihe-in -74.58, 86.02 APE8-rot-na 29.44 APE67-dihe-in -63.23, -19.28 -52.13, -47.58 APE12-dist-na 7.632 APE11-dist-na 11.213 APE10-dist-na 14.754 APE9-dist-in 6.457 Y774E None None XRAY 1.65 0.173 0.21 A 302 274 7 0 0 7 [[615, 876]] 1.0 2vx1 TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
2X9FA 608 888 987.0 X9F:1889 Type1 Inactive DFGin 6.208 14.33 BLBminus -134.1, -172.08 65.01, 71.96 -106.66, 162.22 301.36, 107.12 163.16, 158.85 in-in in 7.543 Saltbr-in 2.703 HRD-in -73.92, -48.13 77.71, -16.54 in-out-in SNCioi out-in ActLoopNT-out 9.79 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.56, 149.08 APE9-dihe-in -55.67, 129.32 APE8-dihe-in -83.14, 89.74 APE8-rot-na 29.6 APE67-dihe-in -62.34, -22.56 -52.45, -48.78 APE12-dist-na 8.363 APE11-dist-na 11.417 APE10-dist-na 15.416 APE9-dist-in 6.34 Y774E None None XRAY 1.75 0.159 0.194 A 302 265 16 0 0 13 [[615, 876]] 1.0 2x9f TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
4BB4A 606 888 987.0 32W:1889 Type1 Inactive DFGin 6.157 15.017 BLBminus -130.67, -169.51 67.48, 72.63 -108.12, 154.59 297.87, 101.54 -178.32, 152.16 in-in in 7.837 Saltbr-in 2.762 HRD-in -66.92, -53.73 77.56, -19.3 in-out-in SNCioi out-in ActLoopNT-out 9.775 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.62, 151.71 APE9-dihe-in -62.33, 126.62 APE8-dihe-in -77.5, 86.29 APE8-rot-na 30.68 APE67-dihe-in -58.13, -23.28 -40.61, -55.64 APE12-dist-na 999.0 APE11-dist-na 11.829 APE10-dist-na 15.992 APE9-dist-in 6.552 Y774E None None XRAY 1.65 0.209 0.236 A 302 265 18 0 0 15 [[615, 876]] 1.0 4bb4 TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
2XVDA 607 888 987.0 AS6:1889 Type1.5_Back Inactive DFGin 6.242 14.578 BLBminus -134.76, 179.07 81.42, 84.67 -123.21, 165.83 300.45, 112.56 155.1, 172.66 in-in in 7.878 Saltbr-in 2.716 HRD-in -78.13, -48.34 77.25, -18.84 in-out-in SNCioi out-in ActLoopNT-out 9.819 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.57, 150.05 APE9-dihe-in -55.61, 128.05 APE8-dihe-in -79.95, 87.35 APE8-rot-na 28.9 APE67-dihe-in -63.17, -19.45 -49.03, -49.22 APE12-dist-na 8.444 APE11-dist-na 11.89 APE10-dist-na 15.867 APE9-dist-in 6.411 Y774E None None XRAY 1.7 0.177 0.209 A 302 270 12 0 0 9 [[615, 876]] 1.0 2xvd TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
2YN8A 608 888 987.0 STU:1889 Type1 Inactive DFGin 6.427 14.617 None -130.9, 178.33 70.32, 85.06 -121.95, 999.0 309.1, 102.44 999.0, 999.0 in-in in 7.533 Saltbr-in 2.751 HRD-in -74.77, -43.96 71.71, -21.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.38 APE8-rot-na 24.51 APE67-dihe-in -59.12, -26.62 -41.36, -49.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 A 298 253 28 0 0 23 [[615, 876]] 1.0 2yn8 TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
2YN8B 606 888 987.0 STU:1889 Type1 Inactive DFGin 6.429 14.627 None -131.1, 178.0 70.17, 85.21 -120.37, 999.0 309.66, 103.01 999.0, 999.0 in-in in 7.486 Saltbr-in 2.76 HRD-in -75.37, -48.88 76.16, -20.77 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.61 APE8-rot-na 24.46 APE67-dihe-in -59.58, -26.36 -40.69, -50.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 B 298 260 23 0 0 23 [[615, 876]] 1.0 2yn8 TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
2VWUA 609 887 987.0 7X1:1888 Type1 Inactive DFGin 6.077 15.924 None -124.83, -150.81 63.15, 75.45 -124.13, 999.0 300.91, 99.28 999.0, 999.0 in-in in 8.075 Saltbr-in 2.914 HRD-in -76.46, -48.16 73.47, -11.39 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.21 APE8-dihe-in -73.39, 85.33 APE8-rot-na 28.9 APE67-dihe-in -73.59, -6.79 -48.01, -50.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.358 Y774E None None XRAY 2.0 0.177 0.209 A 302 253 26 0 0 22 [[615, 876]] 1.0 2vwu TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
2VWVA 606 885 987.0 7X3:1888 Type1 Inactive DFGin 5.922 15.598 None -133.23, -172.3 65.63, 73.48 -107.63, 999.0 299.15, 99.0 999.0, 999.0 in-in in 8.587 Saltbr-in 2.623 HRD-in -81.9, -48.15 79.25, -19.08 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 11.23 APE9-dihe-in -83.5, 125.27 APE8-dihe-in -64.05, 86.66 APE8-rot-na 24.68 APE67-dihe-in -70.9, -11.59 -54.32, -49.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.603 Y774E None None XRAY 1.9 0.241 0.287 A 302 255 25 0 0 21 [[615, 876]] 1.0 2vwv TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
2VWWA 609 887 987.0 7X2:1888 Type1 Inactive DFGin 6.066 15.752 None -127.97, -175.21 79.12, 85.48 -128.75, 999.0 298.95, 96.97 999.0, 999.0 in-in in 8.06 Saltbr-in 2.98 HRD-in -81.76, -48.87 81.8, -14.84 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.85 APE8-dihe-in -74.53, 86.32 APE8-rot-na 30.17 APE67-dihe-in -77.13, -5.49 -50.75, -49.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.35 Y774E None None XRAY 1.9 0.186 0.229 A 302 253 26 0 0 22 [[615, 876]] 1.0 2vww TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
6FNIA 607 889 987.0 DXH:1001 Type2 Inactive DFGout 12.891 11.223 BBAminus -132.29, -177.43 -151.21, 106.22 -87.14, -10.74 305.49, 139.99 54.93, -138.11 in-in in 8.012 Saltbr-in 2.61 HRD-in -71.99, -50.26 79.58, -12.75 in-out-out SNCioo out-out ActLoopNT-out 19.363 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.75 APE8-dihe-in -88.04, 75.6 APE8-rot-na 351.76 APE67-dihe-in -74.35, -4.02 -75.63, -20.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.96 Y774E,A803V,V870I None None XRAY 1.468 0.224 0.236 A 297 261 22 0 0 17 [[615, 876]] 1.0 6fni TYR_EPHB4_HUMAN TYR 4.2e-105 356.7 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
6FNJA 607 888 987.0 DWT:1001 Type2 Inactive DFGout 13.021 10.928 BBAminus -134.64, -177.12 -148.76, 111.17 -93.99, 3.1 297.73, 155.63 70.63, -173.0 in-in in 7.718 Saltbr-in 2.604 HRD-in -73.95, -48.96 80.96, -17.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.39 APE8-dihe-out -76.9, 41.13 APE8-rot-na 20.91 APE67-dihe-in -77.95, -8.69 -49.83, -42.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.553 Y774E,A803V,V870I None None XRAY 1.239 0.209 0.224 A 297 262 20 0 0 20 [[615, 876]] 1.0 6fnj TYR_EPHB4_HUMAN TYR 4.2e-105 356.7 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
6FNJB 607 888 987.0 DWT:1001 Type2 Inactive DFGout 13.065 10.952 BBAminus -136.37, -175.7 -150.64, 109.69 -93.24, 2.06 298.88, 154.22 71.04, -164.55 in-in in 7.764 Saltbr-in 2.786 HRD-in -72.47, -48.77 81.73, -19.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.84 APE8-dihe-out -68.28, 43.94 APE8-rot-na 27.17 APE67-dihe-in -75.87, -7.79 -52.15, -45.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.294 Y774E,A803V,V870I None None XRAY 1.239 0.209 0.224 B 297 262 20 0 0 20 [[615, 876]] 1.0 6fnj TYR_EPHB4_HUMAN TYR 4.2e-105 356.7 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
6FNLA 607 888 987.0 No_ligand No_ligand None DFGin 5.878 15.674 BLAminus -131.81, -173.59 71.94, 76.75 -109.07, -10.52 295.76, 100.61 -115.48, 999.0 in-in in 8.17 Saltbr-in 3.201 HRD-in -75.8, -47.92 75.96, -12.97 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 41.74 APE9-dihe-in -75.1, 127.77 APE8-dihe-in -74.57, 87.67 APE8-rot-na 29.53 APE67-dihe-in -73.26, -6.87 -55.8, -49.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.634 Y774E,A803V,V870I None None XRAY 1.269 0.197 0.213 A 297 262 20 0 0 20 [[615, 876]] 1.0 6fnl TYR_EPHB4_HUMAN TYR 4.2e-105 356.7 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
3ZEWA 609 888 987.0 STU:1889 Type1 None DFGin 6.122 14.359 BLAminus -139.16, 174.72 57.83, 79.91 -97.95, 22.7 299.52, 94.02 -63.4, -45.19 in-in in 8.066 Saltbr-in 2.796 HRD-in -71.2, -51.67 69.26, -8.65 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 56.2 APE9-dihe-in -113.28, 124.67 APE8-dihe-in -75.39, 88.73 APE8-rot-na 23.8 APE67-dihe-in -74.18, -2.68 -39.84, -58.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.292 APE9-dist-in 6.071 None PTR774 PTR774 XRAY 2.5 0.24 0.282 A 298 270 10 0 0 6 [[615, 876]] 1.0 3zew TYR_EPHB4_HUMAN TYR 2.6e-104 354.1 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
3ZEWB 609 887 987.0 STU:1888 Type1 None DFGin 6.6 14.69 BLAminus -136.46, 179.33 65.25, 57.03 -88.32, 123.85 306.76, 101.31 132.26, 999.0 in-none in 7.638 Saltbr-none 999.0 HRD-in -68.01, -45.09 76.33, -22.89 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.88 APE8-dihe-in -93.06, 95.29 APE8-rot-na 27.85 APE67-dihe-in -68.25, -2.97 -47.06, -56.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.554 None PTR774 PTR774 XRAY 2.5 0.24 0.282 B 298 252 27 0 0 21 [[615, 876]] 1.0 3zew TYR_EPHB4_HUMAN TYR 2.6e-104 354.1 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4

TYR_EPHB4 (Ephrin type-B receptor 4)

Total number of chains: 24
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 11 45.8% 2VWXA
DFGin BLAminus 5 20.8% AF-P54760-K1A
DFGin None 5 20.8% 2YN8B
DFGout BBAminus 3 12.5% 6FNJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EPHB4_HUMAN AF-P54760-K1A P54760 607 884 987.0 No_ligand No_ligand Active DFGin 5.974 13.869 BLAminus -139.74, -179.4 64.18, 66.44 -86.68, 11.54 302.15, 96.73 -58.75, -33.49 in-in in 7.984 Saltbr-in 2.704 HRD-in -80.56, -43.43 66.67, -18.44 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.66, 132.17 APE9-dihe-in -122.16, 137.66 APE8-dihe-in -75.12, 84.65 APE8-rot-na 34.37 APE67-dihe-in -67.33, -22.06 -45.78, -45.95 APE12-dist-na 13.481 APE11-dist-na 9.813 APE10-dist-na 10.422 APE9-dist-in 6.359 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[615, 876]] 1.0 AF-P54760-K1 Homo sapiens TYR_EPHB4_HUMAN TYR 2e-104 354.4 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN AF-P54760-K3A P54760 607 884 987.0 No_ligand No_ligand Active DFGin 5.806 14.151 BLAminus -143.99, -175.54 62.87, 66.13 -83.54, 8.28 297.5, 100.05 -58.46, -33.53 in-in in 8.059 Saltbr-in 2.682 HRD-in -82.2, -47.78 67.39, -9.2 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.19, 139.12 APE9-dihe-in -138.81, 146.93 APE8-dihe-in -78.16, 77.82 APE8-rot-na 36.7 APE67-dihe-in -64.24, -26.99 -41.53, -46.33 APE12-dist-na 14.244 APE11-dist-na 10.465 APE10-dist-na 10.193 APE9-dist-in 5.985 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[615, 876]] 1.0 AF-P54760-K3 Homo sapiens TYR_EPHB4_HUMAN TYR 2e-104 354.4 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 6FNKA P54760 604 889 987.0 DXK:1001 Type1 Inactive DFGin 5.785 15.402 BLBminus -132.34, -179.48 79.05, 78.64 -110.02, 142.82 291.49, 104.76 170.31, 139.89 in-in in 8.072 Saltbr-in 2.873 HRD-in -75.87, -49.11 78.1, -14.8 in-out-in SNCioi out-in ActLoopNT-out 9.893 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.14, 155.16 APE9-dihe-in -55.72, 125.74 APE8-dihe-in -77.88, 85.95 APE8-rot-na 29.38 APE67-dihe-in -64.24, -19.7 -51.66, -47.73 APE12-dist-na 999.0 APE11-dist-na 11.556 APE10-dist-na 14.982 APE9-dist-in 6.416 Y774E,A803V,V870I None None XRAY 1.049 0.196 0.22 A 297 274 12 0 0 12 [[615, 876]] 1.0 6fnk Homo sapiens TYR_EPHB4_HUMAN TYR 4.2e-105 356.7 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 6FNMA P54760 608 889 987.0 1N1:1001 Type1 Inactive DFGin 5.961 15.769 BLBminus -128.55, -169.2 67.78, 75.65 -110.02, 138.75 293.26, 98.41 179.12, 146.16 in-in in 8.325 Saltbr-in 3.179 HRD-in -76.03, -51.54 81.54, -15.45 in-out-in SNCioi out-in ActLoopNT-out 10.01 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.65, 157.69 APE9-dihe-in -64.87, 128.21 APE8-dihe-in -78.96, 90.14 APE8-rot-na 30.03 APE67-dihe-in -61.19, -22.58 -57.17, -48.0 APE12-dist-na 999.0 APE11-dist-na 11.368 APE10-dist-na 15.034 APE9-dist-in 6.576 Y774E,A803V,V870I None None XRAY 1.157 0.184 0.195 A 297 270 12 0 0 12 [[615, 876]] 1.0 6fnm Homo sapiens TYR_EPHB4_HUMAN TYR 4.2e-105 356.7 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 4AW5A P54760 607 888 987.0 30K:61365 Type1 Inactive DFGin 5.918 15.076 BLBminus -115.6, -155.32 63.85, 73.81 -110.34, -176.13 296.63, 113.1 132.46, 999.0 in-in in 7.859 Saltbr-in 3.091 HRD-in -70.15, -42.22 67.5, -11.8 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 143.07 APE8-dihe-in -82.91, 93.65 APE8-rot-na 28.44 APE67-dihe-in -75.4, -11.75 -51.64, -47.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6 None None None XRAY 2.33 0.194 0.279 A 291 261 21 0 0 21 [[615, 876]] 1.0 4aw5 Homo sapiens TYR_EPHB4_HUMAN TYR 2.4e-104 354.2 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 2VWXA P54760 608 888 987.0 7X4:1889 Type1 Inactive DFGin 6.062 15.525 BLBminus -131.7, 175.26 83.18, 89.55 -120.97, 136.17 291.75, 99.91 176.83, 144.38 in-in in 7.866 Saltbr-in 2.753 HRD-in -69.03, -53.3 76.5, -14.01 in-out-in SNCioi out-in ActLoopNT-out 9.88 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.19, 154.87 APE9-dihe-in -61.39, 127.49 APE8-dihe-in -75.6, 85.97 APE8-rot-na 30.31 APE67-dihe-in -62.78, -19.77 -52.09, -48.79 APE12-dist-na 7.566 APE11-dist-na 11.192 APE10-dist-na 14.742 APE9-dist-in 6.477 Y774E None None XRAY 1.65 0.168 0.209 A 302 274 7 0 0 7 [[615, 876]] 1.0 2vwx Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 2VWYA P54760 608 888 987.0 7X5:1889 Type1 Inactive DFGin 5.975 15.314 BLBminus -130.24, 178.95 77.7, 88.46 -121.39, 135.89 295.36, 99.3 176.24, 150.88 in-in in 7.91 Saltbr-in 2.886 HRD-in -70.47, -50.81 79.51, -13.14 in-out-in SNCioi out-in ActLoopNT-out 10.037 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.43, 158.81 APE9-dihe-in -65.85, 132.14 APE8-dihe-in -80.12, 86.03 APE8-rot-na 32.28 APE67-dihe-in -63.92, -21.59 -53.89, -44.17 APE12-dist-na 7.375 APE11-dist-na 11.051 APE10-dist-na 14.672 APE9-dist-in 6.506 Y774E None None XRAY 1.65 0.19 0.238 A 302 274 7 0 0 7 [[615, 876]] 1.0 2vwy Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 2VWZA P54760 608 888 987.0 7X6:1889 Type1 Inactive DFGin 5.998 15.385 BLBminus -131.74, 178.07 81.02, 89.07 -120.62, 135.23 292.73, 100.19 177.61, 146.72 in-in in 7.898 Saltbr-in 2.807 HRD-in -73.17, -49.73 76.87, -12.59 in-out-in SNCioi out-in ActLoopNT-out 9.963 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.02, 156.88 APE9-dihe-in -64.46, 130.34 APE8-dihe-in -77.08, 84.67 APE8-rot-na 29.41 APE67-dihe-in -69.47, -18.21 -49.97, -46.03 APE12-dist-na 7.524 APE11-dist-na 11.198 APE10-dist-na 14.848 APE9-dist-in 6.559 Y774E None None XRAY 1.65 0.17 0.205 A 302 274 7 0 0 7 [[615, 876]] 1.0 2vwz Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 2VX0A P54760 608 888 987.0 7X7:1889 Type1 Inactive DFGin 6.056 15.407 BLBminus -143.81, 173.4 80.11, 86.54 -119.94, 137.85 294.49, 102.39 174.61, 145.02 in-in in 7.875 Saltbr-in 2.742 HRD-in -76.09, -48.2 78.58, -18.57 in-out-in SNCioi out-in ActLoopNT-out 10.28 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.92, 159.94 APE9-dihe-in -65.58, 131.65 APE8-dihe-in -77.85, 83.81 APE8-rot-na 31.95 APE67-dihe-in -65.25, -23.14 -49.53, -44.88 APE12-dist-na 999.0 APE11-dist-na 11.04 APE10-dist-na 14.741 APE9-dist-in 6.499 Y774E None None XRAY 2.1 0.187 0.233 A 302 273 8 0 0 8 [[615, 876]] 1.0 2vx0 Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 2VX1A P54760 608 888 987.0 7X8:1889 Type1 Inactive DFGin 5.991 15.42 BLBminus -129.17, 177.79 80.46, 88.46 -119.62, 136.3 293.32, 97.76 177.93, 147.99 in-in in 7.915 Saltbr-in 2.817 HRD-in -72.22, -48.58 77.96, -12.84 in-out-in SNCioi out-in ActLoopNT-out 9.968 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.61, 154.3 APE9-dihe-in -59.44, 127.59 APE8-dihe-in -74.58, 86.02 APE8-rot-na 29.44 APE67-dihe-in -63.23, -19.28 -52.13, -47.58 APE12-dist-na 7.632 APE11-dist-na 11.213 APE10-dist-na 14.754 APE9-dist-in 6.457 Y774E None None XRAY 1.65 0.173 0.21 A 302 274 7 0 0 7 [[615, 876]] 1.0 2vx1 Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 2X9FA P54760 608 888 987.0 X9F:1889 Type1 Inactive DFGin 6.208 14.33 BLBminus -134.1, -172.08 65.01, 71.96 -106.66, 162.22 301.36, 107.12 163.16, 158.85 in-in in 7.543 Saltbr-in 2.703 HRD-in -73.92, -48.13 77.71, -16.54 in-out-in SNCioi out-in ActLoopNT-out 9.79 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.56, 149.08 APE9-dihe-in -55.67, 129.32 APE8-dihe-in -83.14, 89.74 APE8-rot-na 29.6 APE67-dihe-in -62.34, -22.56 -52.45, -48.78 APE12-dist-na 8.363 APE11-dist-na 11.417 APE10-dist-na 15.416 APE9-dist-in 6.34 Y774E None None XRAY 1.75 0.159 0.194 A 302 265 16 0 0 13 [[615, 876]] 1.0 2x9f Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 4BB4A P54760 606 888 987.0 32W:1889 Type1 Inactive DFGin 6.157 15.017 BLBminus -130.67, -169.51 67.48, 72.63 -108.12, 154.59 297.87, 101.54 -178.32, 152.16 in-in in 7.837 Saltbr-in 2.762 HRD-in -66.92, -53.73 77.56, -19.3 in-out-in SNCioi out-in ActLoopNT-out 9.775 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.62, 151.71 APE9-dihe-in -62.33, 126.62 APE8-dihe-in -77.5, 86.29 APE8-rot-na 30.68 APE67-dihe-in -58.13, -23.28 -40.61, -55.64 APE12-dist-na 999.0 APE11-dist-na 11.829 APE10-dist-na 15.992 APE9-dist-in 6.552 Y774E None None XRAY 1.65 0.209 0.236 A 302 265 18 0 0 15 [[615, 876]] 1.0 4bb4 Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 2XVDA P54760 607 888 987.0 AS6:1889 Type1.5_Back Inactive DFGin 6.242 14.578 BLBminus -134.76, 179.07 81.42, 84.67 -123.21, 165.83 300.45, 112.56 155.1, 172.66 in-in in 7.878 Saltbr-in 2.716 HRD-in -78.13, -48.34 77.25, -18.84 in-out-in SNCioi out-in ActLoopNT-out 9.819 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.57, 150.05 APE9-dihe-in -55.61, 128.05 APE8-dihe-in -79.95, 87.35 APE8-rot-na 28.9 APE67-dihe-in -63.17, -19.45 -49.03, -49.22 APE12-dist-na 8.444 APE11-dist-na 11.89 APE10-dist-na 15.867 APE9-dist-in 6.411 Y774E None None XRAY 1.7 0.177 0.209 A 302 270 12 0 0 9 [[615, 876]] 1.0 2xvd Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 2YN8A P54760 608 888 987.0 STU:1889 Type1 Inactive DFGin 6.427 14.617 None -130.9, 178.33 70.32, 85.06 -121.95, 999.0 309.1, 102.44 999.0, 999.0 in-in in 7.533 Saltbr-in 2.751 HRD-in -74.77, -43.96 71.71, -21.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.38 APE8-rot-na 24.51 APE67-dihe-in -59.12, -26.62 -41.36, -49.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 A 298 253 28 0 0 23 [[615, 876]] 1.0 2yn8 Homo sapiens TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 2YN8B P54760 606 888 987.0 STU:1889 Type1 Inactive DFGin 6.429 14.627 None -131.1, 178.0 70.17, 85.21 -120.37, 999.0 309.66, 103.01 999.0, 999.0 in-in in 7.486 Saltbr-in 2.76 HRD-in -75.37, -48.88 76.16, -20.77 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.61 APE8-rot-na 24.46 APE67-dihe-in -59.58, -26.36 -40.69, -50.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 B 298 260 23 0 0 23 [[615, 876]] 1.0 2yn8 Homo sapiens TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 2VWUA P54760 609 887 987.0 7X1:1888 Type1 Inactive DFGin 6.077 15.924 None -124.83, -150.81 63.15, 75.45 -124.13, 999.0 300.91, 99.28 999.0, 999.0 in-in in 8.075 Saltbr-in 2.914 HRD-in -76.46, -48.16 73.47, -11.39 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.21 APE8-dihe-in -73.39, 85.33 APE8-rot-na 28.9 APE67-dihe-in -73.59, -6.79 -48.01, -50.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.358 Y774E None None XRAY 2.0 0.177 0.209 A 302 253 26 0 0 22 [[615, 876]] 1.0 2vwu Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 2VWVA P54760 606 885 987.0 7X3:1888 Type1 Inactive DFGin 5.922 15.598 None -133.23, -172.3 65.63, 73.48 -107.63, 999.0 299.15, 99.0 999.0, 999.0 in-in in 8.587 Saltbr-in 2.623 HRD-in -81.9, -48.15 79.25, -19.08 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 11.23 APE9-dihe-in -83.5, 125.27 APE8-dihe-in -64.05, 86.66 APE8-rot-na 24.68 APE67-dihe-in -70.9, -11.59 -54.32, -49.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.603 Y774E None None XRAY 1.9 0.241 0.287 A 302 255 25 0 0 21 [[615, 876]] 1.0 2vwv Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 2VWWA P54760 609 887 987.0 7X2:1888 Type1 Inactive DFGin 6.066 15.752 None -127.97, -175.21 79.12, 85.48 -128.75, 999.0 298.95, 96.97 999.0, 999.0 in-in in 8.06 Saltbr-in 2.98 HRD-in -81.76, -48.87 81.8, -14.84 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.85 APE8-dihe-in -74.53, 86.32 APE8-rot-na 30.17 APE67-dihe-in -77.13, -5.49 -50.75, -49.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.35 Y774E None None XRAY 1.9 0.186 0.229 A 302 253 26 0 0 22 [[615, 876]] 1.0 2vww Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 6FNIA P54760 607 889 987.0 DXH:1001 Type2 Inactive DFGout 12.891 11.223 BBAminus -132.29, -177.43 -151.21, 106.22 -87.14, -10.74 305.49, 139.99 54.93, -138.11 in-in in 8.012 Saltbr-in 2.61 HRD-in -71.99, -50.26 79.58, -12.75 in-out-out SNCioo out-out ActLoopNT-out 19.363 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.75 APE8-dihe-in -88.04, 75.6 APE8-rot-na 351.76 APE67-dihe-in -74.35, -4.02 -75.63, -20.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.96 Y774E,A803V,V870I None None XRAY 1.468 0.224 0.236 A 297 261 22 0 0 17 [[615, 876]] 1.0 6fni Homo sapiens TYR_EPHB4_HUMAN TYR 4.2e-105 356.7 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 6FNJA P54760 607 888 987.0 DWT:1001 Type2 Inactive DFGout 13.021 10.928 BBAminus -134.64, -177.12 -148.76, 111.17 -93.99, 3.1 297.73, 155.63 70.63, -173.0 in-in in 7.718 Saltbr-in 2.604 HRD-in -73.95, -48.96 80.96, -17.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.39 APE8-dihe-out -76.9, 41.13 APE8-rot-na 20.91 APE67-dihe-in -77.95, -8.69 -49.83, -42.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.553 Y774E,A803V,V870I None None XRAY 1.239 0.209 0.224 A 297 262 20 0 0 20 [[615, 876]] 1.0 6fnj Homo sapiens TYR_EPHB4_HUMAN TYR 4.2e-105 356.7 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 6FNJB P54760 607 888 987.0 DWT:1001 Type2 Inactive DFGout 13.065 10.952 BBAminus -136.37, -175.7 -150.64, 109.69 -93.24, 2.06 298.88, 154.22 71.04, -164.55 in-in in 7.764 Saltbr-in 2.786 HRD-in -72.47, -48.77 81.73, -19.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.84 APE8-dihe-out -68.28, 43.94 APE8-rot-na 27.17 APE67-dihe-in -75.87, -7.79 -52.15, -45.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.294 Y774E,A803V,V870I None None XRAY 1.239 0.209 0.224 B 297 262 20 0 0 20 [[615, 876]] 1.0 6fnj Homo sapiens TYR_EPHB4_HUMAN TYR 4.2e-105 356.7 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 6FNLA P54760 607 888 987.0 No_ligand No_ligand None DFGin 5.878 15.674 BLAminus -131.81, -173.59 71.94, 76.75 -109.07, -10.52 295.76, 100.61 -115.48, 999.0 in-in in 8.17 Saltbr-in 3.201 HRD-in -75.8, -47.92 75.96, -12.97 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 41.74 APE9-dihe-in -75.1, 127.77 APE8-dihe-in -74.57, 87.67 APE8-rot-na 29.53 APE67-dihe-in -73.26, -6.87 -55.8, -49.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.634 Y774E,A803V,V870I None None XRAY 1.269 0.197 0.213 A 297 262 20 0 0 20 [[615, 876]] 1.0 6fnl Homo sapiens TYR_EPHB4_HUMAN TYR 4.2e-105 356.7 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 3ZEWA P54760 609 888 987.0 STU:1889 Type1 None DFGin 6.122 14.359 BLAminus -139.16, 174.72 57.83, 79.91 -97.95, 22.7 299.52, 94.02 -63.4, -45.19 in-in in 8.066 Saltbr-in 2.796 HRD-in -71.2, -51.67 69.26, -8.65 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 56.2 APE9-dihe-in -113.28, 124.67 APE8-dihe-in -75.39, 88.73 APE8-rot-na 23.8 APE67-dihe-in -74.18, -2.68 -39.84, -58.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.292 APE9-dist-in 6.071 None PTR774 PTR774 XRAY 2.5 0.24 0.282 A 298 270 10 0 0 6 [[615, 876]] 1.0 3zew Homo sapiens TYR_EPHB4_HUMAN TYR 2.6e-104 354.1 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
EPHB4_HUMAN 3ZEWB P54760 609 887 987.0 STU:1888 Type1 None DFGin 6.6 14.69 BLAminus -136.46, 179.33 65.25, 57.03 -88.32, 123.85 306.76, 101.31 132.26, 999.0 in-none in 7.638 Saltbr-none 999.0 HRD-in -68.01, -45.09 76.33, -22.89 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.88 APE8-dihe-in -93.06, 95.29 APE8-rot-na 27.85 APE67-dihe-in -68.25, -2.97 -47.06, -56.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.554 None PTR774 PTR774 XRAY 2.5 0.24 0.282 B 298 252 27 0 0 21 [[615, 876]] 1.0 3zew Homo sapiens TYR_EPHB4_HUMAN TYR 2.6e-104 354.1 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4

TYR_EPHB4 (Ephrin type-B receptor 4)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name