CMGC_DYRK1A (Dual specificity tyrosine-phosphorylation-regulated kinase 1A)

Total number of chains: 233
Active chains: 145
Family: CMGC
Uniprot: DYR1A_HUMAN
Kinase Domain Residues: 159 - 479
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 225 96.6% AF-Q13627-K1A
DFGin None 6 2.6% 6UIPA
DFGin ABAminus 2 0.9% 6UIPB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
7A4OA 136 481 763.0 ANP:501 ATPlike Active DFGin 7.404 15.034 BLAminus -121.6, 173.77 67.88, 73.96 -92.34, 22.26 284.87, 82.1 -70.26, -21.97 in-in in 8.684 Saltbr-in 2.793 HRD-in -65.03, -49.19 79.83, -0.94 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.61, 174.39 APE9-dihe-na 70.74, 151.67 APE8-dihe-in -72.34, 134.57 APE8-rot-in 295.77 APE67-dihe-in -65.19, -24.46 -43.45, -47.13 APE12-dist-in 10.098 APE11-dist-in 12.237 APE10-dist-in 7.723 APE9-dist-in 3.156 None PTR321 PTR321 XRAY 1.9 0.18 0.203 A 382 341 5 0 0 0 [[159, 479]] 1.0 7a4o CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
AF-Q13627-K1A 151 487 763.0 No_ligand No_ligand Active DFGin 7.099 14.822 BLAminus -126.07, 174.88 65.04, 63.05 -78.7, 14.51 284.78, 80.05 -60.76, -33.65 in-in in 8.656 Saltbr-in 2.714 HRD-in -68.27, -34.35 64.03, -15.38 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.02, 176.42 APE9-dihe-na 59.84, 143.69 APE8-dihe-in -63.5, 138.24 APE8-rot-in 290.81 APE67-dihe-in -65.87, -20.9 -54.43, -42.41 APE12-dist-in 12.758 APE11-dist-in 11.125 APE10-dist-in 7.099 APE9-dist-in 2.964 None None None AF2 -1.0 1.0 1.0 A 337 337 0 0 0 0 [[159, 479]] 1.0 AF-Q13627-K1 CMGC_DYRK1A_HUMAN CMGC 6.5e-91 310.6 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
AF-Q13627-K3A 151 487 763.0 No_ligand No_ligand Active DFGin 7.022 14.493 BLAminus -128.19, 173.68 64.75, 64.37 -75.81, 14.75 289.44, 85.21 -64.6, -21.99 in-in in 8.717 Saltbr-in 2.697 HRD-in -69.38, -38.91 69.17, -10.28 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.77, 176.19 APE9-dihe-na 61.66, 135.13 APE8-dihe-in -60.79, 140.78 APE8-rot-in 290.77 APE67-dihe-in -67.98, -20.6 -54.86, -44.85 APE12-dist-in 12.238 APE11-dist-in 10.675 APE10-dist-in 6.727 APE9-dist-in 3.139 None None None AF2 -1.0 1.0 1.0 A 337 337 0 0 0 0 [[159, 479]] 1.0 AF-Q13627-K3 CMGC_DYRK1A_HUMAN CMGC 6.5e-91 310.6 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6T6AD 135 481 763.0 No_ligand No_ligand Active DFGin 7.121 14.681 BLAminus -122.22, 178.29 61.07, 75.83 -93.67, 30.29 285.84, 74.34 -78.24, -5.35 in-in in 8.633 Saltbr-in 2.942 HRD-in -62.69, -43.95 76.48, -5.88 in-in-in SNCiii in-in ActLoopNT-in 2.847 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.02, 169.54 APE9-dihe-na 78.04, 146.93 APE8-dihe-in -67.8, 143.97 APE8-rot-in 270.75 APE67-dihe-in -62.33, -22.62 -60.21, -42.06 APE12-dist-in 12.775 APE11-dist-in 11.385 APE10-dist-in 7.064 APE9-dist-in 3.124 None PTR321 PTR321 XRAY 2.8 0.207 0.242 D 361 347 0 0 0 0 [[159, 479]] 1.0 6t6a CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6LN1A 135 480 763.0 EKU:60501 Type1 Active DFGin 7.54 14.912 BLAminus -115.21, 178.19 62.1, 76.45 -91.5, 24.99 284.48, 77.86 -70.41, -32.19 in-in in 8.828 Saltbr-in 2.784 HRD-in -69.61, -44.35 80.94, -0.24 in-in-in SNCiii in-in ActLoopNT-in 2.699 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -92.07, 176.48 APE9-dihe-na 66.77, 147.87 APE8-dihe-in -74.39, 150.81 APE8-rot-in 343.05 APE67-dihe-in -53.64, -21.6 -48.78, -54.67 APE12-dist-in 12.977 APE11-dist-in 11.304 APE10-dist-in 7.182 APE9-dist-in 3.189 None PTR321 PTR321 XRAY 2.699 0.217 0.277 A 347 341 5 0 0 0 [[159, 479]] 1.0 6ln1 CMGC_DYRK1A_HUMAN CMGC 4.7e-90 307.8 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6LN1B 140 479 763.0 EKU:60501 Type1 Active DFGin 7.089 14.398 BLAminus -101.75, -177.71 57.0, 58.3 -78.78, 41.72 301.2, 75.16 -82.62, -11.77 in-in in 8.771 Saltbr-in 2.6 HRD-in -46.38, -56.71 79.08, 7.56 in-in-in SNCiii in-in ActLoopNT-in 2.587 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 154.6 APE9-dihe-na 91.42, 164.72 APE8-dihe-in -88.63, 126.25 APE8-rot-in 268.81 APE67-dihe-in -84.49, -12.92 -41.57, -22.59 APE12-dist-in 13.502 APE11-dist-in 11.71 APE10-dist-in 7.576 APE9-dist-in 3.096 None PTR321 PTR321 XRAY 2.699 0.217 0.277 B 347 330 10 0 0 4 [[159, 479]] 1.0 6ln1 CMGC_DYRK1A_HUMAN CMGC 4.7e-90 307.8 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A4RA 148 479 763.0 QY8:60501 Type1 Active DFGin 7.3 14.891 BLAminus -123.91, 164.94 70.73, 83.02 -95.06, 19.69 291.95, 75.45 -62.6, -28.49 in-in in 8.514 Saltbr-in 2.704 HRD-in -61.82, -47.31 74.74, 3.26 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.99, 160.33 APE9-dihe-na 76.72, 147.14 APE8-dihe-in -69.21, 138.67 APE8-rot-in 293.85 APE67-dihe-in -64.87, -21.48 -52.75, -46.28 APE12-dist-in 12.299 APE11-dist-in 11.025 APE10-dist-in 7.23 APE9-dist-in 3.125 None PTR321 PTR321 XRAY 1.8 0.164 0.194 A 355 329 3 0 0 0 [[159, 479]] 1.0 7a4r CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A4RB 148 479 763.0 QY8:60501 Type1 Active DFGin 7.208 14.962 BLAminus -119.24, 168.89 69.18, 79.44 -94.17, 25.13 286.75, 83.25 -70.93, -17.0 in-in in 8.768 Saltbr-in 2.72 HRD-in -64.89, -47.68 76.51, 0.83 in-in-in SNCiii in-in ActLoopNT-in 2.773 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.84, 166.7 APE9-dihe-na 79.54, 145.8 APE8-dihe-in -71.28, 139.09 APE8-rot-in 294.44 APE67-dihe-in -65.98, -21.95 -52.32, -45.54 APE12-dist-in 12.987 APE11-dist-in 11.288 APE10-dist-in 7.136 APE9-dist-in 3.129 None PTR321 PTR321 XRAY 1.8 0.164 0.194 B 355 326 6 0 0 0 [[159, 479]] 1.0 7a4r CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A52B 148 479 763.0 QYB:60501 Type1 Active DFGin 7.429 14.685 BLAminus -117.36, 166.99 75.18, 78.44 -92.53, 26.04 294.13, 77.59 -62.87, -25.68 in-in in 8.756 Saltbr-in 2.849 HRD-in -65.57, -49.16 78.32, 2.35 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.88, 160.75 APE9-dihe-na 80.13, 142.69 APE8-dihe-in -66.42, 140.08 APE8-rot-in 292.67 APE67-dihe-in -65.51, -22.87 -52.45, -45.87 APE12-dist-in 12.973 APE11-dist-in 11.27 APE10-dist-in 7.231 APE9-dist-in 3.214 None PTR321 PTR321 XRAY 2.1 0.167 0.206 B 355 326 6 0 0 0 [[159, 479]] 1.0 7a52 CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJMA 148 479 763.0 RKW:60501 Type1 Active DFGin 7.265 15.083 BLAminus -113.57, 168.88 72.84, 94.57 -110.24, 26.23 282.42, 78.09 -74.69, -26.47 in-in in 8.683 Saltbr-in 2.872 HRD-in -61.05, -48.34 70.03, 7.39 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.12, 155.94 APE9-dihe-na 76.79, 143.51 APE8-dihe-in -62.38, 139.96 APE8-rot-in 262.82 APE67-dihe-in -62.73, -28.02 -49.34, -49.5 APE12-dist-in 11.834 APE11-dist-in 10.579 APE10-dist-in 6.991 APE9-dist-in 3.106 None PTR321 PTR321 XRAY 2.4 0.164 0.21 A 355 329 3 0 0 0 [[159, 479]] 1.0 7ajm CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJMB 148 479 763.0 RKW:60501 Type1 Active DFGin 6.994 14.671 BLAminus -112.64, 170.76 72.56, 91.79 -109.62, 28.16 283.39, 77.01 -72.83, -14.74 in-in in 8.845 Saltbr-in 2.814 HRD-in -64.07, -48.69 74.15, 3.15 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.54, 168.59 APE9-dihe-na 74.49, 143.62 APE8-dihe-in -65.42, 136.09 APE8-rot-in 307.57 APE67-dihe-in -62.29, -26.67 -49.12, -47.25 APE12-dist-in 12.723 APE11-dist-in 11.028 APE10-dist-in 6.764 APE9-dist-in 3.101 None PTR321 PTR321 XRAY 2.4 0.164 0.21 B 355 326 6 0 0 0 [[159, 479]] 1.0 7ajm CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJSA 148 479 763.0 RKH:60501 Type1 Active DFGin 7.392 14.924 BLAminus -118.68, 165.34 71.79, 87.71 -102.61, 24.08 288.44, 78.59 -63.05, -35.5 in-in in 8.753 Saltbr-in 2.748 HRD-in -60.3, -47.5 67.56, 13.64 in-in-in SNCiii in-in ActLoopNT-in 2.832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.78, 153.94 APE9-dihe-na 77.54, 146.15 APE8-dihe-in -64.0, 138.0 APE8-rot-in 250.19 APE67-dihe-in -60.02, -31.0 -48.17, -52.76 APE12-dist-in 11.961 APE11-dist-in 10.616 APE10-dist-in 6.978 APE9-dist-in 3.153 None PTR321 PTR321 XRAY 2.15 0.163 0.2 A 355 329 3 0 0 0 [[159, 479]] 1.0 7ajs CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJSB 148 479 763.0 RKH:60501 Type1 Active DFGin 7.162 14.64 BLAminus -115.69, 165.45 71.0, 84.62 -94.55, 26.84 288.65, 78.98 -76.35, -12.23 in-in in 8.769 Saltbr-in 2.943 HRD-in -67.11, -52.31 82.14, -1.84 in-in-in SNCiii in-in ActLoopNT-in 2.832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.36, 162.48 APE9-dihe-na 80.28, 144.7 APE8-dihe-in -73.09, 139.12 APE8-rot-in 302.28 APE67-dihe-in -65.82, -22.22 -51.22, -44.57 APE12-dist-in 12.902 APE11-dist-in 11.077 APE10-dist-in 6.906 APE9-dist-in 3.004 None PTR321 PTR321 XRAY 2.15 0.163 0.2 B 355 326 6 0 0 0 [[159, 479]] 1.0 7ajs CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A4SA 149 481 763.0 QYE:501 Type1 Active DFGin 7.532 15.086 BLAminus -138.93, -174.53 57.29, 81.7 -100.85, 35.37 281.58, 79.44 -74.97, -23.82 in-in in 9.32 Saltbr-in 2.944 HRD-in -72.17, -47.36 73.35, 1.71 in-in-in SNCiii in-in ActLoopNT-in 3.05 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.71, 169.75 APE9-dihe-na 81.31, 157.64 APE8-dihe-in -82.41, 132.6 APE8-rot-in 288.96 APE67-dihe-in -59.27, -30.96 -45.34, -50.09 APE12-dist-in 13.06 APE11-dist-in 11.627 APE10-dist-in 7.172 APE9-dist-in 3.27 None PTR321 PTR321 XRAY 3.1 0.187 0.243 A 359 331 2 0 0 0 [[159, 479]] 1.0 7a4s CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A4ZA 148 481 763.0 6SD:60501 Type1 Active DFGin 7.3 14.456 BLAminus -123.85, 174.34 70.88, 81.03 -96.04, 32.37 287.17, 75.22 -72.9, -22.44 in-in in 8.592 Saltbr-in 2.704 HRD-in -62.51, -50.76 77.01, -4.38 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.05, 171.4 APE9-dihe-na 73.73, 155.23 APE8-dihe-in -74.89, 141.08 APE8-rot-in 296.68 APE67-dihe-in -55.98, -24.62 -56.22, -49.4 APE12-dist-in 12.89 APE11-dist-in 11.225 APE10-dist-in 6.887 APE9-dist-in 3.048 None PTR321 PTR321 XRAY 1.9 0.175 0.215 A 359 330 4 0 0 0 [[159, 479]] 1.0 7a4z CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A51A 148 481 763.0 QYK:60501 Type1 Active DFGin 7.291 14.599 BLAminus -122.4, 177.29 65.77, 77.26 -91.33, 30.79 285.93, 79.92 -72.92, -25.25 in-in in 8.818 Saltbr-in 2.674 HRD-in -57.59, -54.42 79.24, -4.5 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.35, 171.53 APE9-dihe-na 74.18, 152.76 APE8-dihe-in -73.09, 137.72 APE8-rot-in 302.32 APE67-dihe-in -57.09, -27.14 -52.91, -48.55 APE12-dist-in 12.924 APE11-dist-in 11.273 APE10-dist-in 6.852 APE9-dist-in 3.051 None PTR321 PTR321 XRAY 1.9 0.176 0.22 A 359 330 4 0 0 0 [[159, 479]] 1.0 7a51 CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A53A 148 481 763.0 QYZ:60501 Type1 Active DFGin 6.956 14.876 BLAminus -124.21, 176.82 60.68, 75.14 -93.92, 34.06 288.73, 77.63 -73.67, -23.0 in-in in 8.892 Saltbr-in 2.46 HRD-in -59.2, -53.12 79.89, -5.25 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.62, 170.93 APE9-dihe-na 78.31, 140.71 APE8-dihe-in -58.15, 138.28 APE8-rot-in 298.09 APE67-dihe-in -53.16, -31.74 -53.07, -51.87 APE12-dist-in 12.976 APE11-dist-in 10.873 APE10-dist-in 6.772 APE9-dist-in 3.148 None PTR321 PTR321 XRAY 2.2 0.221 0.277 A 359 329 5 0 0 0 [[159, 479]] 1.0 7a53 CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A53B 148 481 763.0 QYZ:60501 Type1 Active DFGin 6.959 14.912 BLAminus -126.16, 176.02 60.73, 71.28 -92.14, 32.04 282.75, 96.35 -75.78, -25.86 in-in in 8.559 Saltbr-in 2.618 HRD-in -58.54, -51.47 78.72, -0.57 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.26, 164.66 APE9-dihe-na 73.43, 144.67 APE8-dihe-in -58.03, 137.93 APE8-rot-in 308.72 APE67-dihe-in -53.34, -33.44 -52.19, -50.33 APE12-dist-in 13.334 APE11-dist-in 11.167 APE10-dist-in 7.421 APE9-dist-in 2.938 None PTR321 PTR321 XRAY 2.2 0.221 0.277 B 359 328 6 0 0 0 [[159, 479]] 1.0 7a53 CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A5DA 148 481 763.0 QYW:60503 Type1 Active DFGin 7.291 14.499 BLAminus -125.92, 173.48 71.61, 80.32 -97.3, 32.34 286.41, 76.72 -76.78, -19.61 in-in in 8.581 Saltbr-in 2.928 HRD-in -61.07, -50.08 76.51, -7.31 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.46, 171.52 APE9-dihe-na 73.74, 152.43 APE8-dihe-in -73.09, 139.23 APE8-rot-in 301.1 APE67-dihe-in -59.42, -24.32 -53.95, -47.3 APE12-dist-in 12.903 APE11-dist-in 11.253 APE10-dist-in 6.819 APE9-dist-in 3.043 None PTR321 PTR321 XRAY 1.8 0.169 0.198 A 359 330 4 0 0 0 [[159, 479]] 1.0 7a5d CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A5LA 148 481 763.0 QZW:60501 Type1 Active DFGin 7.218 14.635 BLAminus -121.54, 170.14 72.24, 87.61 -101.02, 30.38 286.05, 77.12 -71.68, -20.82 in-in in 8.522 Saltbr-in 2.809 HRD-in -64.85, -49.91 77.97, -7.38 in-in-in SNCiii in-in ActLoopNT-in 2.76 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.06, 173.85 APE9-dihe-na 71.88, 150.72 APE8-dihe-in -74.11, 138.59 APE8-rot-in 300.11 APE67-dihe-in -57.42, -25.87 -52.04, -49.48 APE12-dist-in 12.969 APE11-dist-in 11.336 APE10-dist-in 6.922 APE9-dist-in 3.017 None PTR321 PTR321 XRAY 2.1 0.17 0.219 A 359 330 4 0 0 0 [[159, 479]] 1.0 7a5l CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A5NA 148 481 763.0 R05:60501 Type1 Active DFGin 7.403 14.447 BLAminus -130.77, 171.88 72.71, 82.27 -106.45, 26.81 288.21, 62.13 -65.93, -43.81 in-in in 8.598 Saltbr-in 3.065 HRD-in -57.21, -52.7 74.49, 12.94 in-in-in SNCiii in-in ActLoopNT-in 3.062 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.21, 148.03 APE9-dihe-na 71.58, 141.19 APE8-dihe-in -66.77, 132.98 APE8-rot-in 271.46 APE67-dihe-in -59.22, -30.19 -42.88, -51.66 APE12-dist-in 11.248 APE11-dist-in 9.343 APE10-dist-in 6.727 APE9-dist-in 3.128 None PTR321 PTR321 XRAY 2.3 0.222 0.285 A 359 331 3 0 0 0 [[159, 479]] 1.0 7a5n CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A5NB 148 481 763.0 R05:60501 Type1 Active DFGin 7.141 14.629 BLAminus -127.78, 175.57 50.44, 91.01 -100.1, 27.58 280.57, 76.94 -87.61, 4.92 in-in in 8.555 Saltbr-in 3.016 HRD-in -52.87, -55.56 83.95, -3.37 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.68, 165.98 APE9-dihe-na 74.29, 148.76 APE8-dihe-in -64.04, 140.88 APE8-rot-in 335.23 APE67-dihe-in -57.78, -36.24 -50.19, -48.03 APE12-dist-in 13.004 APE11-dist-in 10.844 APE10-dist-in 6.638 APE9-dist-in 3.12 None PTR321 PTR321 XRAY 2.3 0.222 0.285 B 359 325 9 0 0 0 [[159, 479]] 1.0 7a5n CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJ2A 148 481 763.0 RJ5:501 Type1 Active DFGin 7.24 14.559 BLAminus -122.01, 172.44 70.8, 81.8 -97.31, 27.59 285.79, 75.24 -65.4, -26.17 in-in in 8.494 Saltbr-in 2.647 HRD-in -59.33, -51.1 76.85, -6.27 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.89, 169.24 APE9-dihe-na 76.24, 151.09 APE8-dihe-in -74.37, 141.15 APE8-rot-in 296.76 APE67-dihe-in -60.14, -26.69 -54.23, -46.92 APE12-dist-in 12.982 APE11-dist-in 11.374 APE10-dist-in 6.836 APE9-dist-in 3.025 None PTR321 PTR321 XRAY 2.1 0.177 0.218 A 359 330 4 0 0 0 [[159, 479]] 1.0 7aj2 CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJ4A 149 481 763.0 RHZ:501 Type1 Active DFGin 7.311 14.601 BLAminus -123.99, 173.51 70.54, 81.2 -94.73, 29.42 286.45, 75.23 -67.9, -25.54 in-in in 8.635 Saltbr-in 2.816 HRD-in -57.38, -53.76 80.58, -8.62 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.55, 172.78 APE9-dihe-na 75.87, 151.36 APE8-dihe-in -72.21, 138.63 APE8-rot-in 297.12 APE67-dihe-in -55.82, -28.26 -51.87, -50.68 APE12-dist-in 12.866 APE11-dist-in 11.261 APE10-dist-in 6.705 APE9-dist-in 3.037 None PTR321 PTR321 XRAY 2.0 0.172 0.212 A 359 329 4 0 0 0 [[159, 479]] 1.0 7aj4 CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJ5A 149 481 763.0 RHW:501 Type1 Active DFGin 7.347 14.591 BLAminus -124.58, 171.68 71.78, 84.04 -100.42, 29.77 286.07, 78.8 -68.78, -26.1 in-in in 8.591 Saltbr-in 2.731 HRD-in -66.86, -51.83 82.75, -10.17 in-in-in SNCiii in-in ActLoopNT-in 2.826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.64, 172.12 APE9-dihe-na 70.48, 150.71 APE8-dihe-in -69.64, 139.8 APE8-rot-in 304.28 APE67-dihe-in -56.6, -26.89 -56.07, -46.59 APE12-dist-in 12.766 APE11-dist-in 11.205 APE10-dist-in 6.736 APE9-dist-in 3.05 None PTR321 PTR321 XRAY 2.0 0.173 0.202 A 359 330 3 0 0 0 [[159, 479]] 1.0 7aj5 CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJ7A 149 481 763.0 RHT:501 Type1 Active DFGin 7.213 14.444 BLAminus -137.43, 175.11 63.05, 82.92 -98.13, 25.37 284.49, 76.3 -61.96, -29.41 in-in in 8.512 Saltbr-in 2.773 HRD-in -62.96, -50.98 78.34, -8.02 in-in-in SNCiii in-in ActLoopNT-in 2.952 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.89, 173.67 APE9-dihe-na 76.79, 147.68 APE8-dihe-in -65.86, 142.81 APE8-rot-in 285.72 APE67-dihe-in -58.43, -30.42 -57.45, -46.57 APE12-dist-in 12.549 APE11-dist-in 11.153 APE10-dist-in 6.711 APE9-dist-in 2.857 None PTR321 PTR321 XRAY 2.9 0.187 0.244 A 359 329 4 0 0 0 [[159, 479]] 1.0 7aj7 CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJ8A 148 481 763.0 RJ8:501 Type1 Active DFGin 7.295 14.549 BLAminus -122.29, 170.47 71.74, 84.57 -99.84, 28.97 281.02, 79.91 -71.8, -23.08 in-in in 8.537 Saltbr-in 2.697 HRD-in -60.09, -51.67 74.99, -7.51 in-in-in SNCiii in-in ActLoopNT-in 2.81 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.41, 173.91 APE9-dihe-na 73.53, 152.08 APE8-dihe-in -72.76, 139.89 APE8-rot-in 300.81 APE67-dihe-in -58.72, -27.07 -52.93, -47.73 APE12-dist-in 12.8 APE11-dist-in 11.225 APE10-dist-in 6.7 APE9-dist-in 2.973 None PTR321 PTR321 XRAY 2.0 0.175 0.21 A 359 330 4 0 0 0 [[159, 479]] 1.0 7aj8 CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJAA 148 481 763.0 RJ2:501 Type1 Active DFGin 7.291 14.665 BLAminus -122.57, -179.95 65.98, 77.73 -92.38, 29.12 284.23, 75.93 -66.67, -27.05 in-in in 8.531 Saltbr-in 3.04 HRD-in -57.61, -51.76 76.82, -10.69 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.46, 175.17 APE9-dihe-na 69.93, 152.41 APE8-dihe-in -73.84, 143.1 APE8-rot-in 301.04 APE67-dihe-in -58.66, -26.17 -57.24, -46.95 APE12-dist-in 12.858 APE11-dist-in 11.253 APE10-dist-in 6.811 APE9-dist-in 2.994 None PTR321 PTR321 XRAY 2.2 0.17 0.206 A 359 330 4 0 0 0 [[159, 479]] 1.0 7aja CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJWA 149 481 763.0 RKQ:501 Type1 Active DFGin 7.15 14.109 BLAminus -134.56, 173.1 66.48, 91.61 -108.25, 30.66 287.96, 79.17 -74.2, -20.6 in-in in 8.555 Saltbr-in 2.654 HRD-in -67.52, -49.1 73.04, -0.56 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.59, 173.44 APE9-dihe-na 72.74, 148.59 APE8-dihe-in -66.33, 137.19 APE8-rot-in 261.72 APE67-dihe-in -58.85, -29.4 -50.84, -53.2 APE12-dist-in 12.66 APE11-dist-in 10.887 APE10-dist-in 6.549 APE9-dist-in 2.84 None PTR321 PTR321 XRAY 2.8 0.182 0.237 A 359 330 3 0 0 0 [[159, 479]] 1.0 7ajw CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AKLA 148 481 763.0 RK5:501 Type1 Active DFGin 7.3 14.425 BLAminus -122.02, 174.03 72.11, 83.92 -100.72, 31.09 288.14, 76.27 -72.0, -23.45 in-in in 8.638 Saltbr-in 2.745 HRD-in -60.22, -54.09 78.11, -4.59 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.03, 174.13 APE9-dihe-na 72.3, 150.01 APE8-dihe-in -71.28, 141.43 APE8-rot-in 296.39 APE67-dihe-in -55.01, -28.18 -52.85, -51.29 APE12-dist-in 12.783 APE11-dist-in 11.183 APE10-dist-in 6.726 APE9-dist-in 3.081 None PTR321 PTR321 XRAY 2.0 0.169 0.21 A 359 330 4 0 0 0 [[159, 479]] 1.0 7akl CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6A1FA 134 483 763.0 9OF:807 Type1 Active DFGin 7.205 15.092 BLAminus -125.52, 173.04 69.56, 79.06 -100.37, 18.23 289.23, 81.85 -66.74, -28.25 in-in in 8.712 Saltbr-in 2.843 HRD-in -63.72, -44.37 75.39, -2.34 in-in-in SNCiii in-in ActLoopNT-in 2.826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.51, 164.33 APE9-dihe-na 78.19, 142.16 APE8-dihe-in -71.23, 146.24 APE8-rot-in 287.31 APE67-dihe-in -64.89, -24.24 -54.81, -45.1 APE12-dist-in 13.001 APE11-dist-in 10.937 APE10-dist-in 7.397 APE9-dist-in 3.189 None PTR321 PTR321 XRAY 1.5 0.178 0.195 A 360 346 4 0 0 0 [[159, 479]] 1.0 6a1f CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6A1GA 134 480 763.0 9OL:801 Type1 Active DFGin 7.443 15.234 BLAminus -131.63, 174.89 62.52, 74.46 -86.81, 24.41 283.22, 87.78 -81.01, -15.6 in-in in 8.67 Saltbr-in 2.915 HRD-in -61.79, -54.2 82.78, 1.79 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.6, 165.45 APE9-dihe-na 76.44, 148.51 APE8-dihe-in -74.95, 145.84 APE8-rot-in 297.26 APE67-dihe-in -65.55, -18.66 -55.25, -42.45 APE12-dist-in 13.856 APE11-dist-in 11.648 APE10-dist-in 7.423 APE9-dist-in 3.22 None PTR321 PTR321 XRAY 2.15 0.227 0.272 A 360 338 9 0 0 0 [[159, 479]] 1.0 6a1g CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6A1GB 135 480 763.0 9OL:801 Type1 Active DFGin 7.579 15.287 BLAminus -122.59, 172.34 65.77, 71.51 -90.8, 21.72 282.42, 87.2 -69.78, -18.18 in-in in 8.764 Saltbr-in 2.721 HRD-in -62.09, -51.04 83.6, -3.9 in-in-in SNCiii in-in ActLoopNT-in 2.747 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.01, 163.93 APE9-dihe-na 74.32, 145.62 APE8-dihe-in -65.74, 146.16 APE8-rot-in 294.53 APE67-dihe-in -67.18, -18.01 -56.08, -44.17 APE12-dist-in 13.833 APE11-dist-in 11.814 APE10-dist-in 7.752 APE9-dist-in 3.148 None PTR321 PTR321 XRAY 2.15 0.227 0.272 B 360 338 8 0 0 0 [[159, 479]] 1.0 6a1g CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8YEVA 135 480 763.0 CUE:501 Type1 Active DFGin 7.434 14.786 BLAminus -118.94, 172.54 64.6, 78.63 -91.29, 26.52 288.98, 71.88 -65.34, -22.12 in-in in 8.522 Saltbr-in 2.577 HRD-in -68.73, -47.85 77.13, 4.82 in-in-in SNCiii in-in ActLoopNT-in 2.782 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.05, 170.5 APE9-dihe-na 69.2, 142.92 APE8-dihe-in -70.94, 147.42 APE8-rot-in 313.88 APE67-dihe-in -60.8, -23.15 -60.0, -43.7 APE12-dist-in 12.556 APE11-dist-in 11.383 APE10-dist-in 7.294 APE9-dist-in 3.152 None PTR321 PTR321 XRAY 2.252 0.187 0.239 A 360 346 0 0 0 0 [[159, 479]] 1.0 8yev CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8YEVB 135 480 763.0 CUE:501 Type1 Active DFGin 7.16 14.723 BLAminus -120.23, 173.78 62.44, 74.7 -88.8, 24.95 292.77, 72.65 -67.21, -11.0 in-in in 8.498 Saltbr-in 2.873 HRD-in -63.02, -42.24 73.2, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.663 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.96, 167.57 APE9-dihe-na 75.54, 148.76 APE8-dihe-in -70.82, 139.27 APE8-rot-in 281.75 APE67-dihe-in -60.51, -21.18 -55.07, -44.69 APE12-dist-in 12.796 APE11-dist-in 11.433 APE10-dist-in 7.267 APE9-dist-in 3.135 None PTR321 PTR321 XRAY 2.252 0.187 0.239 B 360 341 5 0 0 0 [[159, 479]] 1.0 8yev CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4MQ1A 135 480 763.0 2C3:501 Type1 Active DFGin 7.28 14.944 BLAminus -107.08, 169.28 64.33, 86.56 -96.37, 23.11 286.39, 71.27 -52.4, -28.63 in-in in 8.847 Saltbr-in 2.938 HRD-in -69.08, -48.33 84.08, -3.18 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.98, 166.32 APE9-dihe-na 74.9, 147.34 APE8-dihe-in -69.7, 145.86 APE8-rot-in 305.52 APE67-dihe-in -59.42, -25.59 -55.64, -47.81 APE12-dist-in 13.636 APE11-dist-in 11.377 APE10-dist-in 7.303 APE9-dist-in 3.132 None PTR321 PTR321 XRAY 2.35 0.204 0.246 A 361 346 0 0 0 0 [[159, 479]] 1.0 4mq1 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4MQ1B 135 480 763.0 2C3:501 Type1 Active DFGin 7.167 14.962 BLAminus -118.05, 178.11 65.5, 78.17 -95.21, 21.1 286.61, 77.13 -53.53, -31.57 in-in in 8.832 Saltbr-in 2.711 HRD-in -66.94, -41.93 74.32, -0.92 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.36, 163.1 APE9-dihe-na 74.84, 141.93 APE8-dihe-in -61.52, 141.81 APE8-rot-in 294.42 APE67-dihe-in -64.73, -20.55 -55.53, -44.91 APE12-dist-in 13.85 APE11-dist-in 11.968 APE10-dist-in 7.434 APE9-dist-in 3.145 None PTR321 PTR321 XRAY 2.35 0.204 0.246 B 361 341 5 0 0 0 [[159, 479]] 1.0 4mq1 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4MQ1C 135 479 763.0 2C3:501 Type1 Active DFGin 7.123 14.743 BLAminus -115.5, 174.34 57.95, 89.02 -100.48, 19.79 291.2, 71.21 -59.19, -10.35 in-in in 8.677 Saltbr-in 2.838 HRD-in -64.04, -46.07 77.17, 1.7 in-in-in SNCiii in-in ActLoopNT-in 2.825 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.41, 171.13 APE9-dihe-na 68.46, 151.93 APE8-dihe-in -76.63, 143.11 APE8-rot-in 282.43 APE67-dihe-in -62.99, -29.42 -51.54, -49.58 APE12-dist-in 13.421 APE11-dist-in 12.36 APE10-dist-in 7.454 APE9-dist-in 3.19 None PTR321 PTR321 XRAY 2.35 0.204 0.246 C 361 329 16 0 0 0 [[159, 479]] 1.0 4mq1 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4MQ1D 135 479 763.0 2C3:501 Type1 Active DFGin 7.019 14.808 BLAminus -126.44, 171.84 66.4, 87.23 -103.93, 24.03 286.04, 72.97 -66.45, -19.49 in-in in 8.854 Saltbr-in 3.063 HRD-in -60.3, -51.7 83.34, -2.89 in-in-in SNCiii in-in ActLoopNT-in 2.623 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.6, 163.81 APE9-dihe-na 70.67, 153.02 APE8-dihe-in -82.69, 145.06 APE8-rot-in 286.24 APE67-dihe-in -63.44, -21.16 -53.8, -45.92 APE12-dist-in 13.969 APE11-dist-in 11.879 APE10-dist-in 7.612 APE9-dist-in 3.091 None PTR321 PTR321 XRAY 2.35 0.204 0.246 D 361 337 8 0 0 0 [[159, 479]] 1.0 4mq1 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4MQ2A 136 481 763.0 2C4:501 Type1 Active DFGin 6.868 14.409 BLAminus -121.27, 179.82 65.24, 80.7 -100.33, 34.12 292.19, 76.56 -77.48, -4.08 in-in in 8.662 Saltbr-in 2.601 HRD-in -69.08, -52.44 83.64, -11.94 in-in-in SNCiii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.51, 172.47 APE9-dihe-na 67.48, 158.72 APE8-dihe-in -76.65, 148.34 APE8-rot-in 274.49 APE67-dihe-in -48.43, -32.19 -58.16, -54.33 APE12-dist-in 12.976 APE11-dist-in 11.302 APE10-dist-in 7.083 APE9-dist-in 2.96 None PTR321 PTR321 XRAY 2.8 0.193 0.258 A 361 344 2 0 0 0 [[159, 479]] 1.0 4mq2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4MQ2B 135 480 763.0 2C4:501 Type1 Active DFGin 7.053 14.829 BLAminus -112.51, 178.58 64.85, 72.08 -90.53, 21.44 285.46, 79.73 -54.32, -51.42 in-in in 8.7 Saltbr-in 2.465 HRD-in -55.52, -42.79 72.77, 8.39 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.3, 169.51 APE9-dihe-na 72.97, 142.27 APE8-dihe-in -68.49, 133.29 APE8-rot-in 303.19 APE67-dihe-in -62.35, -17.83 -46.19, -44.59 APE12-dist-in 13.951 APE11-dist-in 11.826 APE10-dist-in 7.221 APE9-dist-in 3.228 None PTR321 PTR321 XRAY 2.8 0.193 0.258 B 361 339 7 0 0 0 [[159, 479]] 1.0 4mq2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4MQ2C 135 480 763.0 2C4:501 Type1 Active DFGin 7.135 14.542 BLAminus -124.8, 176.28 61.28, 87.41 -103.36, 27.2 293.3, 79.71 -80.85, 14.66 in-in in 8.563 Saltbr-in 2.857 HRD-in -66.22, -46.45 80.74, -5.39 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.81, 170.36 APE9-dihe-na 74.19, 145.98 APE8-dihe-in -63.45, 145.7 APE8-rot-in 275.14 APE67-dihe-in -56.78, -28.08 -53.65, -50.23 APE12-dist-in 13.336 APE11-dist-in 11.439 APE10-dist-in 7.154 APE9-dist-in 3.083 None PTR321 PTR321 XRAY 2.8 0.193 0.258 C 361 340 6 0 0 0 [[159, 479]] 1.0 4mq2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4YLJA 135 481 763.0 4E1:505 Type1 Active DFGin 7.171 14.69 BLAminus -120.74, 179.02 60.36, 78.67 -97.57, 26.9 291.22, 73.75 -64.98, -15.53 in-in in 8.716 Saltbr-in 2.986 HRD-in -64.06, -46.78 79.78, -3.33 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.96, 172.9 APE9-dihe-na 73.38, 148.79 APE8-dihe-in -71.08, 143.3 APE8-rot-in 281.86 APE67-dihe-in -60.03, -27.35 -56.02, -46.64 APE12-dist-in 12.415 APE11-dist-in 11.382 APE10-dist-in 7.129 APE9-dist-in 3.148 None PTR321 PTR321 XRAY 2.58 0.193 0.222 A 361 347 0 0 0 0 [[159, 479]] 1.0 4ylj CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4YLJB 134 481 763.0 4E1:508 Type1 Active DFGin 7.17 14.829 BLAminus -121.55, 178.75 61.01, 77.19 -96.15, 26.83 289.05, 74.2 -67.89, -14.86 in-in in 8.741 Saltbr-in 2.994 HRD-in -63.71, -44.48 77.69, -2.83 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.19, 171.89 APE9-dihe-na 74.49, 148.58 APE8-dihe-in -68.34, 142.12 APE8-rot-in 282.31 APE67-dihe-in -56.89, -29.19 -56.17, -46.65 APE12-dist-in 12.631 APE11-dist-in 11.965 APE10-dist-in 7.323 APE9-dist-in 3.115 None PTR321 PTR321 XRAY 2.58 0.193 0.222 B 361 348 0 0 0 0 [[159, 479]] 1.0 4ylj CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4YLJC 135 481 763.0 4E1:503 Type1 Active DFGin 7.205 14.729 BLAminus -122.29, 179.51 59.93, 77.71 -95.82, 25.73 289.89, 74.73 -67.2, -13.85 in-in in 8.697 Saltbr-in 2.963 HRD-in -63.45, -46.33 78.82, -3.67 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.91, 172.11 APE9-dihe-na 74.94, 150.31 APE8-dihe-in -71.52, 143.35 APE8-rot-in 282.23 APE67-dihe-in -59.75, -28.5 -57.04, -44.59 APE12-dist-in 12.408 APE11-dist-in 11.398 APE10-dist-in 7.171 APE9-dist-in 3.131 None PTR321 PTR321 XRAY 2.58 0.193 0.222 C 361 347 0 0 0 0 [[159, 479]] 1.0 4ylj CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4YLJD 134 481 763.0 4E1:505 Type1 Active DFGin 7.199 14.803 BLAminus -121.44, 179.35 58.86, 78.49 -97.14, 26.21 290.36, 74.03 -66.11, -15.53 in-in in 8.75 Saltbr-in 2.981 HRD-in -63.57, -46.82 79.76, -3.19 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.75, 172.88 APE9-dihe-na 73.07, 149.38 APE8-dihe-in -71.54, 142.69 APE8-rot-in 281.4 APE67-dihe-in -59.08, -29.21 -56.77, -45.97 APE12-dist-in 12.518 APE11-dist-in 11.514 APE10-dist-in 7.3 APE9-dist-in 3.134 None PTR321 PTR321 XRAY 2.58 0.193 0.222 D 361 348 0 0 0 0 [[159, 479]] 1.0 4ylj CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4YLKA 134 481 763.0 4E2:519 Type1 Active DFGin 7.158 15.056 BLAminus -121.3, 173.23 68.75, 82.1 -101.46, 18.43 287.84, 80.51 -66.33, -24.85 in-in in 8.808 Saltbr-in 2.835 HRD-in -60.82, -45.77 73.28, 1.75 in-in-in SNCiii in-in ActLoopNT-in 2.798 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.3, 165.02 APE9-dihe-na 76.33, 137.8 APE8-dihe-in -71.51, 143.14 APE8-rot-in 292.21 APE67-dihe-in -62.85, -23.79 -52.79, -45.95 APE12-dist-in 12.9 APE11-dist-in 10.859 APE10-dist-in 7.405 APE9-dist-in 3.227 None PTR321 PTR321 XRAY 1.4 0.156 0.177 A 361 342 6 0 0 0 [[159, 479]] 1.0 4ylk CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4YLLA 134 481 763.0 4E3:515 Type1 Active DFGin 7.124 15.005 BLAminus -121.37, 173.09 67.61, 81.84 -100.09, 19.61 289.57, 78.47 -68.0, -24.32 in-in in 8.778 Saltbr-in 2.819 HRD-in -61.7, -47.42 73.98, 3.3 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.49, 164.4 APE9-dihe-na 78.13, 136.62 APE8-dihe-in -68.39, 143.3 APE8-rot-in 291.54 APE67-dihe-in -64.28, -22.41 -51.37, -47.28 APE12-dist-in 12.865 APE11-dist-in 10.831 APE10-dist-in 7.376 APE9-dist-in 3.217 None PTR321 PTR321 XRAY 1.4 0.152 0.172 A 361 342 6 0 0 0 [[159, 479]] 1.0 4yll CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4YU2A 134 482 763.0 4H5:502 Type1 Active DFGin 7.126 14.681 BLAminus -128.42, 169.74 66.24, 87.83 -106.58, 30.41 288.45, 76.74 -70.77, -21.27 in-in in 8.585 Saltbr-in 2.926 HRD-in -65.53, -46.44 78.54, 3.05 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.92, 172.99 APE9-dihe-na 68.27, 148.59 APE8-dihe-in -64.99, 149.49 APE8-rot-in 273.44 APE67-dihe-in -60.93, -28.26 -62.53, -43.49 APE12-dist-in 12.736 APE11-dist-in 11.533 APE10-dist-in 7.136 APE9-dist-in 3.121 None PTR321 PTR321 XRAY 2.9 0.245 0.277 A 361 349 0 0 0 0 [[159, 479]] 1.0 4yu2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4YU2B 134 481 763.0 4H5:502 Type1 Active DFGin 7.151 14.752 BLAminus -128.64, 169.94 65.22, 90.88 -106.36, 30.6 290.28, 73.66 -70.15, -21.89 in-in in 8.572 Saltbr-in 2.91 HRD-in -64.42, -46.95 79.44, 4.22 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.9, 173.47 APE9-dihe-na 67.52, 148.21 APE8-dihe-in -62.89, 148.04 APE8-rot-in 274.18 APE67-dihe-in -57.33, -29.6 -62.96, -44.24 APE12-dist-in 12.881 APE11-dist-in 11.9 APE10-dist-in 7.282 APE9-dist-in 3.117 None PTR321 PTR321 XRAY 2.9 0.245 0.277 B 361 348 0 0 0 0 [[159, 479]] 1.0 4yu2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4YU2C 135 481 763.0 4H5:502 Type1 Active DFGin 7.149 14.733 BLAminus -129.97, 170.39 64.97, 89.04 -105.39, 29.51 288.7, 75.12 -70.27, -20.52 in-in in 8.571 Saltbr-in 2.901 HRD-in -64.55, -48.15 80.68, 1.77 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.0, 173.91 APE9-dihe-na 67.18, 147.22 APE8-dihe-in -64.46, 149.75 APE8-rot-in 272.34 APE67-dihe-in -59.78, -28.43 -63.46, -43.86 APE12-dist-in 12.803 APE11-dist-in 11.599 APE10-dist-in 7.196 APE9-dist-in 3.145 None PTR321 PTR321 XRAY 2.9 0.245 0.277 C 361 347 0 0 0 0 [[159, 479]] 1.0 4yu2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4YU2D 135 481 763.0 4H5:501 Type1 Active DFGin 7.149 14.755 BLAminus -129.65, 170.04 63.79, 89.4 -106.1, 29.98 289.31, 74.3 -69.85, -20.2 in-in in 8.582 Saltbr-in 2.925 HRD-in -65.3, -48.21 80.59, 2.84 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.24, 173.34 APE9-dihe-na 67.44, 148.12 APE8-dihe-in -63.59, 148.85 APE8-rot-in 273.83 APE67-dihe-in -59.42, -28.15 -62.28, -44.56 APE12-dist-in 12.806 APE11-dist-in 11.569 APE10-dist-in 7.234 APE9-dist-in 3.121 None PTR321 PTR321 XRAY 2.9 0.245 0.277 D 361 347 0 0 0 0 [[159, 479]] 1.0 4yu2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6QU2A 134 482 763.0 JHW:506 Type1 Active DFGin 6.982 14.589 BLAminus -117.63, 177.32 58.78, 78.21 -94.48, 27.81 290.76, 75.74 -69.1, -16.2 in-in in 8.568 Saltbr-in 2.854 HRD-in -61.74, -43.97 72.49, -0.84 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.02, 172.07 APE9-dihe-na 71.62, 149.26 APE8-dihe-in -69.7, 147.81 APE8-rot-in 285.05 APE67-dihe-in -59.57, -29.32 -59.04, -45.45 APE12-dist-in 12.878 APE11-dist-in 11.444 APE10-dist-in 7.011 APE9-dist-in 3.089 None PTR321 PTR321 XRAY 2.9 0.204 0.242 A 361 349 0 0 0 0 [[159, 479]] 1.0 6qu2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6QU2B 134 482 763.0 JHW:508 Type1 Active DFGin 7.005 14.638 BLAminus -117.89, 176.82 58.51, 78.25 -94.64, 27.55 290.8, 75.81 -68.12, -17.63 in-in in 8.561 Saltbr-in 2.852 HRD-in -61.86, -43.77 71.78, 1.07 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.33, 172.98 APE9-dihe-na 71.69, 147.87 APE8-dihe-in -69.83, 147.77 APE8-rot-in 285.59 APE67-dihe-in -59.33, -29.5 -59.31, -45.22 APE12-dist-in 12.876 APE11-dist-in 11.482 APE10-dist-in 7.021 APE9-dist-in 3.097 None PTR321 PTR321 XRAY 2.9 0.204 0.242 B 361 349 0 0 0 0 [[159, 479]] 1.0 6qu2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6QU2C 134 482 763.0 JHW:505 Type1 Active DFGin 7.004 14.655 BLAminus -118.42, 176.92 59.0, 78.18 -94.14, 27.62 291.21, 74.99 -69.86, -15.95 in-in in 8.578 Saltbr-in 2.854 HRD-in -61.48, -44.17 72.54, -0.44 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.57, 172.15 APE9-dihe-na 71.25, 147.44 APE8-dihe-in -70.36, 148.07 APE8-rot-in 286.47 APE67-dihe-in -59.29, -29.31 -59.04, -45.15 APE12-dist-in 12.889 APE11-dist-in 11.507 APE10-dist-in 7.035 APE9-dist-in 3.102 None PTR321 PTR321 XRAY 2.9 0.204 0.242 C 361 349 0 0 0 0 [[159, 479]] 1.0 6qu2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6QU2D 134 482 763.0 JHW:504 Type1 Active DFGin 6.989 14.664 BLAminus -118.28, 176.89 59.45, 77.75 -95.14, 28.05 290.79, 75.43 -69.23, -15.75 in-in in 8.547 Saltbr-in 2.858 HRD-in -61.16, -43.94 72.27, -0.05 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.09, 173.93 APE9-dihe-na 71.93, 148.3 APE8-dihe-in -68.69, 147.47 APE8-rot-in 287.5 APE67-dihe-in -59.03, -30.52 -59.66, -44.67 APE12-dist-in 13.01 APE11-dist-in 11.567 APE10-dist-in 7.068 APE9-dist-in 3.083 None PTR321 PTR321 XRAY 2.9 0.204 0.242 D 361 349 0 0 0 0 [[159, 479]] 1.0 6qu2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6S11A 134 480 763.0 KQE:502 Type1 Active DFGin 7.296 14.892 BLAminus -121.55, 164.1 72.87, 91.72 -105.74, 27.5 285.62, 74.33 -70.05, -23.97 in-in in 8.616 Saltbr-in 2.709 HRD-in -66.61, -45.0 72.81, 4.62 in-in-in SNCiii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.87, 171.94 APE9-dihe-na 69.56, 141.33 APE8-dihe-in -63.19, 142.1 APE8-rot-in 291.08 APE67-dihe-in -52.63, -29.59 -57.6, -48.58 APE12-dist-in 13.815 APE11-dist-in 12.051 APE10-dist-in 7.349 APE9-dist-in 3.108 None PTR321 PTR321 XRAY 2.445 0.173 0.21 A 361 344 3 0 0 0 [[159, 479]] 1.0 6s11 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6S14A 135 481 763.0 KQW:507 Type1 Active DFGin 7.13 14.977 BLAminus -123.96, 169.43 73.07, 84.58 -102.85, 20.91 291.79, 78.47 -63.29, -31.08 in-in in 9.011 Saltbr-in 2.877 HRD-in -63.2, -46.68 75.3, 0.69 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.87, 164.58 APE9-dihe-na 76.07, 137.75 APE8-dihe-in -69.45, 143.91 APE8-rot-in 292.55 APE67-dihe-in -62.58, -24.67 -53.32, -47.34 APE12-dist-in 13.009 APE11-dist-in 10.9 APE10-dist-in 7.342 APE9-dist-in 3.258 None PTR321 PTR321 XRAY 1.05 0.151 0.163 A 361 340 7 0 0 0 [[159, 479]] 1.0 6s14 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6S17A 134 482 763.0 KQK:511 Type1 Active DFGin 7.203 14.902 BLAminus -124.45, 170.29 74.07, 85.62 -100.56, 16.05 291.39, 79.57 -63.97, -27.96 in-in in 8.995 Saltbr-in 2.873 HRD-in -63.13, -46.99 76.01, -0.62 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.8, 167.89 APE9-dihe-na 76.24, 136.82 APE8-dihe-in -67.42, 143.38 APE8-rot-in 293.12 APE67-dihe-in -63.63, -24.34 -54.34, -45.56 APE12-dist-in 13.102 APE11-dist-in 11.031 APE10-dist-in 7.433 APE9-dist-in 3.273 None PTR321 PTR321 XRAY 1.1 0.15 0.163 A 361 343 6 0 0 0 [[159, 479]] 1.0 6s17 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6S1BA 135 481 763.0 KRQ:507 Type1 Active DFGin 7.172 14.948 BLAminus -124.63, 169.27 74.75, 83.95 -103.32, 20.44 289.63, 79.43 -66.28, -30.23 in-in in 9.009 Saltbr-in 2.898 HRD-in -65.04, -45.97 75.32, -1.48 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.45, 158.87 APE9-dihe-na 81.09, 137.58 APE8-dihe-in -68.39, 146.11 APE8-rot-in 293.06 APE67-dihe-in -61.74, -25.57 -57.01, -46.7 APE12-dist-in 13.222 APE11-dist-in 11.017 APE10-dist-in 7.629 APE9-dist-in 3.282 None PTR321 PTR321 XRAY 1.3 0.162 0.179 A 361 338 9 0 0 0 [[159, 479]] 1.0 6s1b CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6S1HA 135 480 763.0 KQZ:504 Type1 Active DFGin 7.168 15.058 BLAminus -123.34, 170.35 73.43, 83.33 -101.5, 17.61 288.45, 79.73 -69.15, -23.93 in-in in 8.678 Saltbr-in 2.895 HRD-in -62.49, -46.68 75.7, -2.5 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.52, 161.84 APE9-dihe-na 78.83, 139.23 APE8-dihe-in -69.82, 141.58 APE8-rot-in 292.61 APE67-dihe-in -62.66, -23.51 -50.81, -48.04 APE12-dist-in 13.048 APE11-dist-in 11.013 APE10-dist-in 7.586 APE9-dist-in 3.222 None PTR321 PTR321 XRAY 1.05 0.141 0.154 A 361 340 6 0 0 0 [[159, 479]] 1.0 6s1h CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6S1IA 135 481 763.0 KR8:503 Type1 Active DFGin 6.898 14.588 BLAminus -126.45, 178.1 62.9, 78.82 -94.61, 26.34 284.66, 74.88 -61.34, -34.33 in-in in 8.697 Saltbr-in 2.792 HRD-in -63.27, -44.28 74.47, -2.25 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.45, 164.14 APE9-dihe-na 77.6, 145.17 APE8-dihe-in -67.72, 141.59 APE8-rot-in 292.76 APE67-dihe-in -56.98, -28.19 -56.25, -45.01 APE12-dist-in 12.54 APE11-dist-in 11.114 APE10-dist-in 6.989 APE9-dist-in 3.126 None PTR321 PTR321 XRAY 2.38 0.202 0.228 A 361 347 0 0 0 0 [[159, 479]] 1.0 6s1i CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6S1IB 135 481 763.0 KR8:505 Type1 Active DFGin 6.965 14.548 BLAminus -125.09, 179.13 61.73, 80.78 -98.89, 25.32 290.26, 72.62 -61.57, -38.18 in-in in 8.772 Saltbr-in 2.834 HRD-in -65.26, -46.98 75.17, -0.72 in-in-in SNCiii in-in ActLoopNT-in 2.741 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.9, 162.85 APE9-dihe-na 78.18, 146.19 APE8-dihe-in -67.03, 141.99 APE8-rot-in 283.82 APE67-dihe-in -57.88, -29.55 -55.88, -45.14 APE12-dist-in 12.921 APE11-dist-in 11.64 APE10-dist-in 7.231 APE9-dist-in 3.076 None PTR321 PTR321 XRAY 2.38 0.202 0.228 B 361 346 1 0 0 0 [[159, 479]] 1.0 6s1i CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6S1IC 135 481 763.0 KR8:505 Type1 Active DFGin 6.883 14.386 BLAminus -125.8, 178.51 61.15, 80.81 -97.76, 24.92 289.88, 75.99 -62.3, -32.74 in-in in 8.686 Saltbr-in 2.628 HRD-in -64.62, -43.93 75.06, -0.23 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.77, 158.73 APE9-dihe-na 76.8, 143.9 APE8-dihe-in -70.32, 140.69 APE8-rot-in 292.97 APE67-dihe-in -57.82, -29.55 -55.13, -45.7 APE12-dist-in 12.064 APE11-dist-in 10.094 APE10-dist-in 6.727 APE9-dist-in 3.071 None PTR321 PTR321 XRAY 2.38 0.202 0.228 C 361 345 2 0 0 1 [[159, 479]] 1.0 6s1i CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6S1ID 135 481 763.0 KR8:503 Type1 Active DFGin 6.958 14.617 BLAminus -125.25, 179.89 61.35, 78.92 -97.88, 24.63 284.55, 81.3 -62.38, -32.93 in-in in 8.646 Saltbr-in 2.758 HRD-in -63.56, -43.98 75.67, -1.81 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.5, 163.63 APE9-dihe-na 78.26, 147.78 APE8-dihe-in -66.75, 142.12 APE8-rot-in 283.64 APE67-dihe-in -57.25, -28.8 -57.5, -45.09 APE12-dist-in 13.463 APE11-dist-in 12.008 APE10-dist-in 7.185 APE9-dist-in 3.177 None PTR321 PTR321 XRAY 2.38 0.202 0.228 D 361 346 1 0 0 1 [[159, 479]] 1.0 6s1i CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6S1JA 134 480 763.0 KRK:501 Type1 Active DFGin 7.155 14.926 BLAminus -128.6, 173.02 72.92, 83.09 -103.37, 19.39 290.16, 84.03 -67.23, -28.05 in-in in 8.909 Saltbr-in 2.826 HRD-in -61.93, -50.27 77.88, -1.33 in-in-in SNCiii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.93, 162.86 APE9-dihe-na 76.64, 138.24 APE8-dihe-in -70.1, 144.21 APE8-rot-in 289.47 APE67-dihe-in -65.12, -21.74 -55.6, -43.87 APE12-dist-in 12.93 APE11-dist-in 10.885 APE10-dist-in 7.495 APE9-dist-in 3.218 None PTR321 PTR321 XRAY 1.408 0.156 0.176 A 361 341 6 0 0 0 [[159, 479]] 1.0 6s1j CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6T6AA 135 481 763.0 MLW:507 Type1 Active DFGin 7.075 14.643 BLAminus -121.66, 177.98 61.35, 75.17 -93.42, 30.57 286.52, 74.8 -78.3, -5.71 in-in in 8.645 Saltbr-in 2.954 HRD-in -61.63, -44.5 74.44, -4.8 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.2, 170.61 APE9-dihe-na 76.22, 146.16 APE8-dihe-in -67.8, 145.05 APE8-rot-in 269.7 APE67-dihe-in -62.62, -23.02 -60.27, -42.85 APE12-dist-in 12.766 APE11-dist-in 11.362 APE10-dist-in 7.034 APE9-dist-in 3.13 None PTR321 PTR321 XRAY 2.8 0.207 0.242 A 361 347 0 0 0 0 [[159, 479]] 1.0 6t6a CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6T6AB 135 481 763.0 MLW:506 Type1 Active DFGin 7.084 14.663 BLAminus -123.66, 178.07 61.12, 75.8 -93.78, 29.12 285.48, 75.25 -75.0, -7.67 in-in in 8.628 Saltbr-in 2.944 HRD-in -61.02, -44.18 75.29, -4.75 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.29, 171.86 APE9-dihe-na 76.73, 147.09 APE8-dihe-in -66.82, 144.9 APE8-rot-in 270.05 APE67-dihe-in -62.24, -23.36 -61.66, -42.17 APE12-dist-in 12.868 APE11-dist-in 11.504 APE10-dist-in 7.122 APE9-dist-in 3.121 None PTR321 PTR321 XRAY 2.8 0.207 0.242 B 361 347 0 0 0 0 [[159, 479]] 1.0 6t6a CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6T6AC 135 481 763.0 MLW:506 Type1 Active DFGin 7.041 14.592 BLAminus -124.36, 178.1 60.98, 75.42 -93.3, 29.52 285.85, 76.28 -78.87, -5.76 in-in in 8.642 Saltbr-in 2.936 HRD-in -63.57, -44.17 76.99, -6.26 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.62, 170.81 APE9-dihe-na 77.22, 146.49 APE8-dihe-in -67.43, 144.4 APE8-rot-in 270.2 APE67-dihe-in -62.89, -21.64 -59.6, -42.66 APE12-dist-in 12.786 APE11-dist-in 11.421 APE10-dist-in 7.043 APE9-dist-in 3.126 None PTR321 PTR321 XRAY 2.8 0.207 0.242 C 361 347 0 0 0 0 [[159, 479]] 1.0 6t6a CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6UWYA 135 481 763.0 QKG:501 Type1 Active DFGin 7.239 14.867 BLAminus -132.26, 176.05 58.86, 71.25 -90.67, 13.27 278.59, 82.94 -60.39, -40.77 in-in in 8.735 Saltbr-in 3.081 HRD-in -61.71, -47.36 76.81, -2.22 in-in-in SNCiii in-in ActLoopNT-in 2.655 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.12, 167.04 APE9-dihe-na 74.27, 150.88 APE8-dihe-in -72.73, 138.41 APE8-rot-in 284.49 APE67-dihe-in -57.43, -28.19 -49.04, -49.4 APE12-dist-in 12.812 APE11-dist-in 11.524 APE10-dist-in 7.209 APE9-dist-in 3.017 None PTR321 PTR321 XRAY 2.95 0.197 0.227 A 361 347 0 0 0 0 [[159, 479]] 1.0 6uwy CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6UWYB 134 481 763.0 QKG:501 Type1 Active DFGin 7.311 15.09 BLAminus -132.37, 173.46 57.96, 71.45 -90.43, 13.0 277.8, 80.83 -60.37, -40.54 in-in in 8.779 Saltbr-in 3.014 HRD-in -61.63, -47.91 76.71, -1.04 in-in-in SNCiii in-in ActLoopNT-in 2.716 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -63.7, 163.69 APE9-dihe-na 74.19, 154.88 APE8-dihe-in -72.83, 138.38 APE8-rot-in 286.89 APE67-dihe-in -59.92, -29.1 -50.36, -49.5 APE12-dist-in 13.664 APE11-dist-in 11.132 APE10-dist-in 7.037 APE9-dist-in 3.012 None PTR321 PTR321 XRAY 2.95 0.197 0.227 B 361 348 0 0 0 0 [[159, 479]] 1.0 6uwy CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6UWYC 135 481 763.0 QKG:501 Type1 Active DFGin 7.448 14.961 BLAminus -132.44, 172.18 56.85, 71.63 -90.4, 12.5 280.91, 80.19 -61.16, -41.17 in-in in 8.661 Saltbr-in 2.875 HRD-in -61.46, -47.79 77.42, -2.34 in-in-in SNCiii in-in ActLoopNT-in 2.77 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.48, 167.68 APE9-dihe-na 74.27, 151.37 APE8-dihe-in -72.8, 138.22 APE8-rot-in 285.1 APE67-dihe-in -57.33, -28.79 -48.84, -49.36 APE12-dist-in 12.866 APE11-dist-in 11.736 APE10-dist-in 7.357 APE9-dist-in 3.02 None PTR321 PTR321 XRAY 2.95 0.197 0.227 C 361 347 0 0 0 0 [[159, 479]] 1.0 6uwy CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6UWYD 134 481 763.0 QKG:501 Type1 Active DFGin 7.138 14.987 BLAminus -133.07, 174.34 57.8, 73.05 -90.03, 14.24 279.65, 81.22 -60.16, -40.68 in-in in 8.748 Saltbr-in 2.975 HRD-in -62.11, -48.37 77.72, -2.5 in-in-in SNCiii in-in ActLoopNT-in 2.725 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.78, 167.27 APE9-dihe-na 74.09, 151.84 APE8-dihe-in -72.45, 137.48 APE8-rot-in 284.95 APE67-dihe-in -57.53, -28.78 -49.33, -49.3 APE12-dist-in 12.8 APE11-dist-in 11.611 APE10-dist-in 7.385 APE9-dist-in 3.072 None PTR321 PTR321 XRAY 2.95 0.197 0.227 D 361 348 0 0 0 0 [[159, 479]] 1.0 6uwy CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8R8EB 135 481 763.0 YOX:502 Type1 Active DFGin 7.069 14.684 BLAminus -127.98, 172.63 62.79, 73.8 -88.81, 28.19 285.67, 76.47 -75.54, -11.12 in-in in 8.71 Saltbr-in 2.951 HRD-in -62.54, -47.06 75.87, -2.9 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.14, 171.54 APE9-dihe-na 74.42, 146.08 APE8-dihe-in -67.71, 141.78 APE8-rot-in 282.59 APE67-dihe-in -59.51, -26.74 -54.99, -45.67 APE12-dist-in 12.585 APE11-dist-in 11.047 APE10-dist-in 6.756 APE9-dist-in 3.113 None PTR321 PTR321 XRAY 2.22 0.2 0.234 B 361 347 0 0 0 0 [[159, 479]] 1.0 8r8e CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8R8EC 136 481 763.0 YOX:502 Type1 Active DFGin 7.188 14.623 BLAminus -130.04, 167.44 62.25, 73.8 -89.0, 26.94 285.37, 75.31 -74.67, -11.09 in-in in 8.643 Saltbr-in 2.589 HRD-in -61.57, -46.23 75.55, -3.28 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.37, 171.41 APE9-dihe-na 75.31, 148.56 APE8-dihe-in -65.26, 141.68 APE8-rot-in 281.12 APE67-dihe-in -59.77, -26.63 -54.67, -46.17 APE12-dist-in 12.705 APE11-dist-in 11.607 APE10-dist-in 7.189 APE9-dist-in 3.167 None PTR321 PTR321 XRAY 2.22 0.2 0.234 C 361 346 0 0 0 0 [[159, 479]] 1.0 8r8e CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8R8ED 135 480 763.0 YOX:501 Type1 Active DFGin 7.027 14.622 BLAminus -127.82, 174.49 61.5, 72.32 -89.25, 27.64 284.65, 74.88 -76.43, -9.3 in-in in 8.69 Saltbr-in 2.92 HRD-in -62.74, -44.79 74.53, -3.37 in-in-in SNCiii in-in ActLoopNT-in 2.679 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.28, 171.24 APE9-dihe-na 73.58, 146.12 APE8-dihe-in -67.75, 140.76 APE8-rot-in 279.97 APE67-dihe-in -58.05, -26.12 -56.64, -45.76 APE12-dist-in 12.399 APE11-dist-in 11.386 APE10-dist-in 6.834 APE9-dist-in 3.119 None None None XRAY 2.22 0.2 0.234 D 361 346 0 0 0 0 [[159, 479]] 1.0 8r8e CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7FHSB 134 481 763.0 4VZ:501 Type1 Active DFGin 7.385 15.0 BLAminus -125.73, 165.21 71.88, 83.89 -101.28, 23.85 281.27, 80.83 -70.35, -20.86 in-in in 8.799 Saltbr-in 2.715 HRD-in -62.95, -48.52 82.4, -4.32 in-in-in SNCiii in-in ActLoopNT-in 2.785 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.22, 160.69 APE9-dihe-na 79.18, 154.0 APE8-dihe-in -69.6, 130.45 APE8-rot-in 276.76 APE67-dihe-in -56.8, -23.49 -48.13, -49.11 APE12-dist-in 13.918 APE11-dist-in 11.969 APE10-dist-in 7.951 APE9-dist-in 3.132 None PTR321 PTR321 XRAY 2.42 0.234 0.275 B 361 342 6 0 0 0 [[159, 479]] 1.0 7fhs CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8T2HA 136 480 763.0 XIR:500 Type1 Active DFGin 7.123 14.605 BLAminus -125.94, 165.89 75.03, 89.05 -105.39, 23.99 289.74, 76.5 -56.41, -37.08 in-in in 8.48 Saltbr-in 2.687 HRD-in -62.3, -50.05 75.05, 4.64 in-in-in SNCiii in-in ActLoopNT-in 2.748 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.86, 166.87 APE9-dihe-na 78.77, 155.11 APE8-dihe-in -78.67, 140.46 APE8-rot-in 283.75 APE67-dihe-in -58.52, -25.12 -50.9, -49.84 APE12-dist-in 12.322 APE11-dist-in 11.973 APE10-dist-in 7.197 APE9-dist-in 2.99 None PTR321 PTR321 XRAY 1.85 0.166 0.213 A 365 339 6 0 0 0 [[159, 479]] 1.0 8t2h CMGC_DYRK1A_HUMAN CMGC 8.8e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8T2HB 135 481 763.0 XIR:500 Type1 Active DFGin 7.088 14.58 BLAminus -125.43, 166.77 72.41, 86.02 -100.65, 24.84 288.66, 75.08 -58.03, -34.69 in-in in 8.595 Saltbr-in 2.706 HRD-in -63.58, -50.21 76.67, 2.87 in-in-in SNCiii in-in ActLoopNT-in 2.762 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.51, 170.94 APE9-dihe-na 73.42, 151.8 APE8-dihe-in -77.86, 142.73 APE8-rot-in 295.35 APE67-dihe-in -69.62, -17.55 -49.75, -46.99 APE12-dist-in 12.643 APE11-dist-in 10.708 APE10-dist-in 6.938 APE9-dist-in 3.04 None PTR321 PTR321 XRAY 1.85 0.166 0.213 B 365 342 5 0 0 0 [[159, 479]] 1.0 8t2h CMGC_DYRK1A_HUMAN CMGC 8.8e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
9CY5A 136 480 763.0 A1A04:500 Type1 Active DFGin 7.147 14.638 BLAminus -122.0, 166.0 76.85, 87.4 -105.55, 21.68 282.78, 84.23 -69.73, -24.49 in-in in 8.504 Saltbr-in 2.313 HRD-in -59.7, -51.34 83.68, -0.54 in-in-in SNCiii in-in ActLoopNT-in 2.771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -96.54, 173.95 APE9-dihe-na 71.15, 158.37 APE8-dihe-in -75.95, 126.8 APE8-rot-in 288.5 APE67-dihe-in -59.95, -29.92 -35.82, -50.5 APE12-dist-in 12.757 APE11-dist-in 12.226 APE10-dist-in 7.349 APE9-dist-in 3.057 None PTR321 PTR321 XRAY 2.49 0.203 0.259 A 365 339 6 0 0 0 [[159, 479]] 1.0 9cy5 CMGC_DYRK1A_HUMAN CMGC 8.8e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
9CY5B 135 481 763.0 A1A04:500 Type1 Active DFGin 7.251 14.584 BLAminus -112.93, 162.83 79.63, 82.51 -96.96, 24.75 288.34, 80.4 -53.23, -41.67 in-in in 8.584 Saltbr-in 2.866 HRD-in -66.43, -49.68 77.31, -1.94 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -92.97, 173.98 APE9-dihe-na 79.25, 156.99 APE8-dihe-in -84.96, 136.04 APE8-rot-in 282.61 APE67-dihe-in -62.99, -28.41 -37.15, -54.75 APE12-dist-in 12.739 APE11-dist-in 12.286 APE10-dist-in 7.174 APE9-dist-in 3.17 None PTR321 PTR321 XRAY 2.49 0.203 0.259 B 365 342 5 0 0 0 [[159, 479]] 1.0 9cy5 CMGC_DYRK1A_HUMAN CMGC 8.8e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
3ANRA 134 481 763.0 HRM:1 Type1 Active DFGin 7.395 14.88 BLAminus -126.97, 175.57 62.29, 87.12 -103.96, 24.02 282.74, 80.66 -67.77, -18.58 in-in in 8.706 Saltbr-in 2.945 HRD-in -59.12, -43.08 70.29, -4.2 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.86, 169.59 APE9-dihe-na 72.59, 157.32 APE8-dihe-in -74.37, 142.22 APE8-rot-in 294.27 APE67-dihe-in -55.49, -26.14 -45.5, -54.94 APE12-dist-in 13.813 APE11-dist-in 12.061 APE10-dist-in 7.955 APE9-dist-in 3.253 None PTR321 PTR321 XRAY 2.6 0.232 0.264 A 368 343 5 0 0 0 [[159, 479]] 1.0 3anr CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4EA 134 480 763.0 7QQ:1482 Type1 Active DFGin 7.22 14.874 BLAminus -126.54, 177.15 58.69, 94.29 -113.21, 22.28 286.19, 77.0 -59.45, -31.21 in-in in 8.568 Saltbr-in 2.779 HRD-in -64.66, -42.27 66.83, 14.81 in-in-in SNCiii in-in ActLoopNT-in 2.662 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.09, 163.61 APE9-dihe-na 69.48, 158.79 APE8-dihe-in -72.55, 147.75 APE8-rot-in 295.07 APE67-dihe-in -58.22, -29.01 -58.76, -47.93 APE12-dist-in 13.575 APE11-dist-in 11.747 APE10-dist-in 7.974 APE9-dist-in 3.174 None PTR321 PTR321 XRAY 2.68 0.237 0.268 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a4e CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4EB 133 480 763.0 7QQ:1482 Type1 Active DFGin 7.399 14.881 BLAminus -121.24, 173.6 64.11, 83.73 -104.73, 23.57 287.63, 75.52 -70.09, -36.48 in-in in 8.688 Saltbr-in 2.932 HRD-in -51.94, -37.2 69.96, 8.72 in-in-in SNCiii in-in ActLoopNT-in 3.115 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.62, 169.1 APE9-dihe-na 63.21, 149.19 APE8-dihe-in -68.01, 145.26 APE8-rot-in 293.25 APE67-dihe-in -62.27, -28.2 -53.9, -51.02 APE12-dist-in 13.549 APE11-dist-in 11.424 APE10-dist-in 7.915 APE9-dist-in 3.305 None PTR321 PTR321 XRAY 2.68 0.237 0.268 B 368 323 25 0 0 0 [[159, 479]] 1.0 5a4e CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4ED 134 480 763.0 7QQ:1482 Type1 Active DFGin 7.084 14.377 BLAminus -127.03, 161.26 72.91, 98.11 -113.73, 26.73 293.48, 83.38 -71.75, -27.39 in-in in 8.717 Saltbr-in 2.757 HRD-in -62.4, -41.11 73.31, 5.6 in-in-in SNCiii in-in ActLoopNT-in 2.978 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.98, 167.15 APE9-dihe-na 68.52, 159.57 APE8-dihe-in -79.96, 125.33 APE8-rot-in 300.98 APE67-dihe-in -48.76, -38.1 -29.58, -60.85 APE12-dist-in 13.723 APE11-dist-in 11.606 APE10-dist-in 7.713 APE9-dist-in 3.246 None PTR321 PTR321 XRAY 2.68 0.237 0.268 D 368 332 15 0 0 0 [[159, 479]] 1.0 5a4e CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4LA 134 480 763.0 ZC3:1481 Type1 Active DFGin 7.234 14.766 BLAminus -122.38, 174.21 65.08, 93.49 -114.73, 26.8 284.64, 84.62 -79.93, -25.42 in-in in 8.428 Saltbr-in 3.23 HRD-in -65.21, -42.7 75.91, 6.95 in-in-in SNCiii in-in ActLoopNT-in 3.107 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.23, 163.1 APE9-dihe-na 70.58, 145.07 APE8-dihe-in -65.43, 141.62 APE8-rot-in 280.27 APE67-dihe-in -60.3, -30.26 -54.35, -42.8 APE12-dist-in 13.568 APE11-dist-in 11.426 APE10-dist-in 7.797 APE9-dist-in 3.088 None PTR321 PTR321 XRAY 2.73 0.224 0.267 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a4l CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4LD 134 479 763.0 ZC3:1480 Type1 Active DFGin 7.353 14.577 BLAminus -132.96, 164.11 69.89, 87.22 -105.39, 34.74 291.55, 76.59 -80.25, -34.64 in-in in 8.659 Saltbr-in 2.941 HRD-in -58.1, -45.98 75.95, 3.48 in-in-in SNCiii in-in ActLoopNT-in 3.239 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.1, 161.63 APE9-dihe-na 71.86, 145.21 APE8-dihe-in -54.07, 139.5 APE8-rot-in 266.11 APE67-dihe-in -50.1, -38.91 -55.61, -48.8 APE12-dist-in 13.859 APE11-dist-in 11.794 APE10-dist-in 7.849 APE9-dist-in 3.338 None PTR321 PTR321 XRAY 2.73 0.224 0.267 D 368 335 11 0 0 0 [[159, 479]] 1.0 5a4l CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4QB 133 480 763.0 Y3L:1482 Type1 Active DFGin 7.332 15.167 BLAminus -119.07, 169.96 69.93, 79.11 -95.25, 24.02 288.84, 81.96 -59.31, -40.09 in-in in 8.8 Saltbr-in 2.743 HRD-in -65.5, -47.61 81.19, 5.21 in-in-in SNCiii in-in ActLoopNT-in 3.026 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.35, 160.28 APE9-dihe-na 76.8, 155.69 APE8-dihe-in -77.08, 143.17 APE8-rot-in 298.14 APE67-dihe-in -56.03, -30.73 -51.27, -50.53 APE12-dist-in 13.619 APE11-dist-in 11.706 APE10-dist-in 7.959 APE9-dist-in 3.304 None PTR321 PTR321 XRAY 2.37 0.208 0.243 B 368 336 12 0 0 0 [[159, 479]] 1.0 5a4q CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4QD 134 479 763.0 Y3L:1481 Type1 Active DFGin 7.54 14.858 BLAminus -122.22, 174.03 62.3, 86.45 -97.65, 23.49 289.45, 76.37 -75.31, -20.37 in-in in 8.511 Saltbr-in 2.499 HRD-in -56.95, -45.96 79.67, 1.76 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.06, 163.2 APE9-dihe-na 73.87, 148.99 APE8-dihe-in -76.47, 142.42 APE8-rot-in 301.45 APE67-dihe-in -56.86, -27.34 -54.99, -48.13 APE12-dist-in 13.838 APE11-dist-in 11.826 APE10-dist-in 7.868 APE9-dist-in 3.329 None PTR321 PTR321 XRAY 2.37 0.208 0.243 D 368 335 11 0 0 0 [[159, 479]] 1.0 5a4q CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4TA 134 480 763.0 AJG:1482 Type1 Active DFGin 7.622 15.274 BLAminus -112.24, -178.72 54.59, 84.96 -104.05, 18.94 273.04, 77.95 -59.69, -39.38 in-in in 8.78 Saltbr-in 3.018 HRD-in -67.27, -38.62 73.07, -10.27 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.67, 162.72 APE9-dihe-na 73.04, 147.49 APE8-dihe-in -69.75, 138.1 APE8-rot-in 286.14 APE67-dihe-in -50.27, -34.74 -54.48, -46.81 APE12-dist-in 13.559 APE11-dist-in 11.324 APE10-dist-in 7.72 APE9-dist-in 3.11 None PTR321 PTR321 XRAY 2.15 0.205 0.234 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a4t CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4TB 133 480 763.0 AJG:1482 Type1 Active DFGin 7.334 14.771 BLAminus -134.42, 173.1 62.66, 77.62 -92.94, 44.39 292.89, 84.38 -83.77, -36.33 in-in in 8.596 Saltbr-in 2.831 HRD-in -64.98, -48.49 78.64, 9.32 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.45, 162.3 APE9-dihe-na 71.65, 143.12 APE8-dihe-in -61.58, 138.14 APE8-rot-in 299.68 APE67-dihe-in -70.11, -29.4 -55.95, -37.08 APE12-dist-in 13.618 APE11-dist-in 11.4 APE10-dist-in 7.822 APE9-dist-in 3.267 None PTR321 PTR321 XRAY 2.15 0.205 0.234 B 368 340 8 0 0 0 [[159, 479]] 1.0 5a4t CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4TD 134 479 763.0 AJG:1481 Type1 Active DFGin 7.489 14.887 BLAminus -117.21, 169.43 64.47, 80.55 -95.84, 25.37 288.01, 79.35 -68.27, -34.89 in-in in 8.669 Saltbr-in 2.892 HRD-in -67.49, -52.96 80.25, 5.24 in-in-in SNCiii in-in ActLoopNT-in 2.879 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.97, 164.66 APE9-dihe-na 70.52, 150.41 APE8-dihe-in -69.54, 148.58 APE8-rot-in 293.88 APE67-dihe-in -54.65, -28.51 -61.96, -48.11 APE12-dist-in 13.83 APE11-dist-in 11.722 APE10-dist-in 7.927 APE9-dist-in 3.124 None PTR321 PTR321 XRAY 2.15 0.205 0.234 D 368 333 13 0 0 0 [[159, 479]] 1.0 5a4t CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A54A 134 480 763.0 5PW:1482 Type1 Active DFGin 7.276 15.215 BLAminus -121.5, 177.39 61.3, 86.79 -106.46, 25.28 279.73, 71.96 -65.24, -32.8 in-in in 8.751 Saltbr-in 3.078 HRD-in -53.91, -44.92 70.91, 12.75 in-in-in SNCiii in-in ActLoopNT-in 3.481 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.16, 159.75 APE9-dihe-na 71.58, 162.32 APE8-dihe-in -77.6, 149.66 APE8-rot-in 289.63 APE67-dihe-in -60.85, -34.82 -58.88, -45.26 APE12-dist-in 13.602 APE11-dist-in 11.614 APE10-dist-in 7.831 APE9-dist-in 3.364 None PTR321 PTR321 XRAY 2.63 0.224 0.255 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a54 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A54B 133 480 763.0 5PW:1482 Type1 Active DFGin 6.963 14.712 BLAminus -134.12, 173.15 68.71, 67.58 -87.74, 26.53 289.52, 85.86 -78.5, -14.3 in-in in 8.811 Saltbr-in 3.073 HRD-in -63.19, -45.3 82.27, -18.93 in-in-in SNCiii in-in ActLoopNT-in 3.486 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.22, 164.07 APE9-dihe-na 69.13, 155.85 APE8-dihe-in -74.78, 146.48 APE8-rot-in 313.35 APE67-dihe-in -58.66, -31.56 -52.07, -50.9 APE12-dist-in 13.415 APE11-dist-in 11.505 APE10-dist-in 7.727 APE9-dist-in 3.182 None PTR321 PTR321 XRAY 2.63 0.224 0.255 B 368 340 8 0 0 0 [[159, 479]] 1.0 5a54 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A54D 134 479 763.0 5PW:1481 Type1 Active DFGin 7.476 14.887 BLAminus -116.89, 166.35 68.67, 97.95 -113.07, 31.59 286.6, 76.44 -75.63, -31.91 in-in in 8.723 Saltbr-in 3.178 HRD-in -62.68, -45.72 73.35, 10.52 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.93, 164.8 APE9-dihe-na 68.14, 162.71 APE8-dihe-in -79.75, 144.04 APE8-rot-in 293.59 APE67-dihe-in -50.71, -34.46 -57.02, -44.94 APE12-dist-in 13.828 APE11-dist-in 11.81 APE10-dist-in 7.781 APE9-dist-in 3.24 None PTR321 PTR321 XRAY 2.63 0.224 0.255 D 368 335 11 0 0 0 [[159, 479]] 1.0 5a54 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIFA 134 480 763.0 B5T:501 Type1 Active DFGin 7.715 15.153 BLAminus -108.17, 168.64 68.55, 82.38 -98.62, 28.92 285.39, 77.1 -72.07, -30.89 in-in in 8.846 Saltbr-in 2.978 HRD-in -66.36, -44.8 74.98, 9.71 in-in-in SNCiii in-in ActLoopNT-in 2.782 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.64, 161.63 APE9-dihe-na 71.89, 150.46 APE8-dihe-in -78.88, 144.18 APE8-rot-in 300.04 APE67-dihe-in -58.53, -31.8 -55.12, -42.87 APE12-dist-in 13.989 APE11-dist-in 11.748 APE10-dist-in 7.965 APE9-dist-in 3.281 None PTR321 PTR321 XRAY 2.22 0.22 0.25 A 368 344 3 0 0 0 [[159, 479]] 1.0 6eif CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIJB 133 480 763.0 B5Z:501 Type1 Active DFGin 7.267 15.528 BLAminus -117.59, 170.7 64.63, 89.36 -107.31, 30.62 285.29, 75.01 -79.8, -27.42 in-in in 9.004 Saltbr-in 3.483 HRD-in -63.56, -41.89 71.27, 6.78 in-in-in SNCiii in-in ActLoopNT-in 2.799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.2, 156.57 APE9-dihe-na 71.57, 144.46 APE8-dihe-in -65.65, 143.73 APE8-rot-in 301.69 APE67-dihe-in -60.34, -27.61 -53.56, -46.19 APE12-dist-in 13.554 APE11-dist-in 11.232 APE10-dist-in 7.686 APE9-dist-in 3.196 None PTR321 PTR321 XRAY 2.42 0.215 0.242 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eij CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIJD 134 479 763.0 B5Z:501 Type1 Active DFGin 7.495 15.445 BLAminus -110.58, 169.11 63.21, 88.34 -100.92, 29.04 284.12, 76.0 -75.59, -27.16 in-in in 9.051 Saltbr-in 2.765 HRD-in -55.24, -46.68 74.47, 11.33 in-in-in SNCiii in-in ActLoopNT-in 2.95 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.83, 166.58 APE9-dihe-na 66.27, 155.62 APE8-dihe-in -75.66, 150.91 APE8-rot-in 302.31 APE67-dihe-in -58.65, -28.49 -61.4, -47.04 APE12-dist-in 13.802 APE11-dist-in 11.742 APE10-dist-in 7.729 APE9-dist-in 3.253 None PTR321 PTR321 XRAY 2.42 0.215 0.242 D 368 339 7 0 0 0 [[159, 479]] 1.0 6eij CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EILA 134 480 763.0 B6B:501 Type1 Active DFGin 7.57 14.97 BLAminus -127.99, 168.56 62.9, 83.29 -100.21, 30.13 286.84, 74.94 -73.55, -27.3 in-in in 8.635 Saltbr-in 2.893 HRD-in -66.02, -40.6 72.49, 2.1 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.15, 170.89 APE9-dihe-na 67.45, 153.11 APE8-dihe-in -71.17, 144.45 APE8-rot-in 292.8 APE67-dihe-in -54.25, -24.55 -56.23, -51.45 APE12-dist-in 13.874 APE11-dist-in 11.853 APE10-dist-in 7.986 APE9-dist-in 3.106 None PTR321 PTR321 XRAY 2.465 0.213 0.254 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eil CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIPB 133 480 763.0 B7B:501 Type1 Active DFGin 7.3 15.137 BLAminus -116.31, 172.99 59.38, 82.91 -97.29, 38.15 294.47, 77.72 -74.08, -35.63 in-in in 9.09 Saltbr-in 2.899 HRD-in -65.81, -47.59 76.49, 9.41 in-in-in SNCiii in-in ActLoopNT-in 3.186 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.16, 160.62 APE9-dihe-na 70.79, 152.01 APE8-dihe-in -70.68, 148.82 APE8-rot-in 294.92 APE67-dihe-in -57.84, -32.79 -60.95, -46.44 APE12-dist-in 13.9 APE11-dist-in 11.499 APE10-dist-in 7.671 APE9-dist-in 3.306 None PTR321 PTR321 XRAY 2.56 0.243 0.266 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eip CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIPD 134 479 763.0 B7B:501 Type1 Active DFGin 7.439 15.077 BLAminus -126.34, 172.93 62.79, 86.26 -101.23, 28.95 288.24, 77.28 -69.9, -27.46 in-in in 8.846 Saltbr-in 2.848 HRD-in -58.79, -41.55 67.62, 10.96 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.57, 164.56 APE9-dihe-na 68.0, 151.01 APE8-dihe-in -69.91, 146.7 APE8-rot-in 286.07 APE67-dihe-in -59.83, -24.78 -58.38, -48.52 APE12-dist-in 13.863 APE11-dist-in 11.61 APE10-dist-in 7.782 APE9-dist-in 3.366 None PTR321 PTR321 XRAY 2.56 0.243 0.266 D 368 333 13 0 0 0 [[159, 479]] 1.0 6eip CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIQD 134 479 763.0 B6Z:501 Type1 Active DFGin 7.574 14.87 BLAminus -119.79, 171.42 62.12, 83.48 -94.95, 33.05 288.92, 76.92 -77.23, -31.31 in-in in 8.77 Saltbr-in 2.825 HRD-in -69.21, -45.78 80.19, 5.53 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.36, 156.34 APE9-dihe-na 80.64, 155.49 APE8-dihe-in -79.45, 139.43 APE8-rot-in 279.91 APE67-dihe-in -60.72, -27.06 -52.76, -47.1 APE12-dist-in 13.959 APE11-dist-in 11.841 APE10-dist-in 7.989 APE9-dist-in 3.232 None PTR321 PTR321 XRAY 2.3 0.22 0.252 D 368 333 13 0 0 0 [[159, 479]] 1.0 6eiq CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EISB 133 480 763.0 B6N:501 Type1 Active DFGin 7.364 15.01 BLAminus -121.04, 176.25 60.21, 78.92 -98.69, 24.99 286.57, 87.15 -70.6, -24.44 in-in in 8.697 Saltbr-in 2.736 HRD-in -63.78, -47.49 73.12, 4.16 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.07, 170.33 APE9-dihe-na 64.55, 152.61 APE8-dihe-in -67.26, 141.38 APE8-rot-in 300.27 APE67-dihe-in -63.11, -23.65 -52.42, -46.34 APE12-dist-in 13.8 APE11-dist-in 11.772 APE10-dist-in 7.906 APE9-dist-in 3.181 None PTR321 PTR321 XRAY 2.36 0.223 0.262 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eis CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EISD 134 479 763.0 B6N:501 Type1 Active DFGin 7.286 15.141 BLAminus -125.52, 165.07 68.69, 87.86 -104.24, 31.22 282.79, 81.9 -77.49, -25.71 in-in in 8.619 Saltbr-in 2.657 HRD-in -61.8, -42.91 69.44, 6.24 in-in-in SNCiii in-in ActLoopNT-in 2.742 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.63, 168.78 APE9-dihe-na 66.0, 152.38 APE8-dihe-in -69.65, 137.97 APE8-rot-in 298.51 APE67-dihe-in -59.57, -25.22 -50.11, -45.93 APE12-dist-in 13.975 APE11-dist-in 11.877 APE10-dist-in 7.865 APE9-dist-in 3.336 None PTR321 PTR321 XRAY 2.36 0.223 0.262 D 368 339 7 0 0 0 [[159, 479]] 1.0 6eis CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EJ4C 135 479 763.0 B7W:501 Type1 Active DFGin 7.399 14.621 BLAminus -127.52, 168.2 60.93, 96.68 -107.48, 20.89 285.11, 74.4 -57.11, -40.86 in-in in 9.022 Saltbr-in 2.977 HRD-in -60.32, -39.77 73.57, -0.65 in-in-in SNCiii in-in ActLoopNT-in 3.283 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.12, 159.98 APE9-dihe-na 72.27, 158.6 APE8-dihe-in -74.01, 154.25 APE8-rot-in 280.21 APE67-dihe-in -64.21, -35.15 -55.76, -52.46 APE12-dist-in 13.833 APE11-dist-in 11.799 APE10-dist-in 7.982 APE9-dist-in 3.286 None PTR321 PTR321 XRAY 2.88 0.222 0.27 C 368 332 13 0 0 0 [[159, 479]] 1.0 6ej4 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6YF8A 134 480 763.0 OPW:501 Type1 Active DFGin 7.367 15.037 BLAminus -107.79, 169.33 69.2, 81.79 -99.28, 28.66 285.18, 77.14 -72.43, -31.23 in-in in 8.601 Saltbr-in 2.847 HRD-in -65.51, -44.05 74.67, 9.56 in-in-in SNCiii in-in ActLoopNT-in 2.722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.05, 162.23 APE9-dihe-na 71.89, 151.15 APE8-dihe-in -78.29, 144.29 APE8-rot-in 300.07 APE67-dihe-in -58.27, -31.82 -55.32, -42.67 APE12-dist-in 13.883 APE11-dist-in 11.463 APE10-dist-in 7.639 APE9-dist-in 3.269 None PTR321 PTR321 XRAY 3.198 0.251 0.283 A 368 342 5 0 0 0 [[159, 479]] 1.0 6yf8 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6YF8B 133 480 763.0 OPW:501 Type1 Active DFGin 7.35 14.819 BLAminus -117.64, 170.81 65.81, 81.87 -100.82, 27.57 293.99, 81.4 -77.25, -30.97 in-in in 8.702 Saltbr-in 2.634 HRD-in -63.24, -42.07 74.0, 14.09 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.69, 162.87 APE9-dihe-na 65.58, 155.56 APE8-dihe-in -69.5, 152.58 APE8-rot-in 294.46 APE67-dihe-in -60.85, -36.35 -65.13, -40.78 APE12-dist-in 13.566 APE11-dist-in 11.269 APE10-dist-in 7.757 APE9-dist-in 3.284 None PTR321 PTR321 XRAY 3.198 0.251 0.283 B 368 340 8 0 0 0 [[159, 479]] 1.0 6yf8 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6YF8D 134 479 763.0 OPW:501 Type1 Active DFGin 7.163 14.672 BLAminus -129.06, 157.06 74.04, 87.38 -102.12, 32.5 287.46, 75.26 -75.18, -28.37 in-in in 8.607 Saltbr-in 3.368 HRD-in -62.03, -42.61 74.97, 8.8 in-in-in SNCiii in-in ActLoopNT-in 3.009 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.1, 162.77 APE9-dihe-na 71.6, 148.13 APE8-dihe-in -72.02, 126.06 APE8-rot-in 276.95 APE67-dihe-in -35.21, -29.98 -36.67, -74.72 APE12-dist-in 13.536 APE11-dist-in 11.438 APE10-dist-in 7.66 APE9-dist-in 3.254 None PTR321 PTR321 XRAY 3.198 0.251 0.283 D 368 331 15 0 0 0 [[159, 479]] 1.0 6yf8 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7Z5NA 135 480 763.0 3NG:501 Type1 Active DFGin 7.332 14.774 BLAminus -125.89, 175.46 60.34, 76.96 -90.72, 25.89 277.64, 75.8 -70.85, -23.55 in-in in 8.867 Saltbr-in 2.627 HRD-in -70.94, -45.64 77.0, -3.79 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.65, -35.2 APE9-dihe-na -94.12, 169.14 APE8-dihe-in -81.45, 135.48 APE8-rot-in 271.72 APE67-dihe-in -57.78, -21.85 -42.59, -54.66 APE12-dist-in 12.682 APE11-dist-in 11.088 APE10-dist-in 6.808 APE9-dist-in 3.373 None PTR321 PTR321 XRAY 2.77 0.207 0.252 A 370 346 0 0 0 0 [[159, 479]] 1.0 7z5n CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7Z5NB 135 480 763.0 3NG:501 Type1 Active DFGin 6.965 15.03 BLAminus -121.53, 177.86 59.36, 74.88 -91.0, 24.04 284.65, 79.36 -69.42, -6.51 in-in in 9.072 Saltbr-in 2.955 HRD-in -65.31, -40.72 67.91, 3.75 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.86, 165.14 APE9-dihe-na 70.53, 140.66 APE8-dihe-in -62.36, 145.8 APE8-rot-in 271.48 APE67-dihe-in -55.51, -24.3 -55.08, -48.98 APE12-dist-in 12.652 APE11-dist-in 11.24 APE10-dist-in 7.392 APE9-dist-in 3.193 None PTR321 PTR321 XRAY 2.77 0.207 0.252 B 370 343 3 0 0 0 [[159, 479]] 1.0 7z5n CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7Z5NC 134 480 763.0 3NG:501 Type1 Active DFGin 7.125 14.845 BLAminus -127.45, -179.8 54.81, 79.63 -96.7, 25.59 287.09, 79.21 -71.97, -4.29 in-in in 9.218 Saltbr-in 2.931 HRD-in -65.84, -47.16 77.48, 0.17 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.48, 175.3 APE9-dihe-na 70.69, 141.68 APE8-dihe-in -71.86, 144.08 APE8-rot-in 308.65 APE67-dihe-in -60.2, -32.88 -49.5, -49.8 APE12-dist-in 13.034 APE11-dist-in 11.534 APE10-dist-in 7.148 APE9-dist-in 3.171 None PTR321 PTR321 XRAY 2.77 0.207 0.252 C 370 344 3 0 0 0 [[159, 479]] 1.0 7z5n CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7Z5ND 135 480 763.0 3NG:501 Type1 Active DFGin 7.13 14.89 BLAminus -128.02, 175.09 60.57, 71.33 -86.84, 26.43 281.73, 81.64 -75.1, -14.91 in-in in 9.081 Saltbr-in 2.672 HRD-in -60.22, -35.39 67.3, 3.71 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -92.57, 171.93 APE9-dihe-na 66.97, 156.51 APE8-dihe-in -85.5, 144.03 APE8-rot-in 283.59 APE67-dihe-in -57.76, -18.64 -49.19, -52.69 APE12-dist-in 12.39 APE11-dist-in 10.732 APE10-dist-in 7.111 APE9-dist-in 3.042 None PTR321 PTR321 XRAY 2.77 0.207 0.252 D 370 338 8 0 0 0 [[159, 479]] 1.0 7z5n CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7Z5NE 135 480 763.0 3NG:501 Type1 Active DFGin 7.188 14.841 BLAminus -123.41, -179.95 58.6, 74.9 -91.66, 28.87 284.52, 74.3 -74.18, -15.86 in-in in 8.932 Saltbr-in 2.599 HRD-in -66.53, -45.73 70.01, 6.86 in-in-in SNCiii in-in ActLoopNT-in 2.729 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.5, 169.99 APE9-dihe-na 69.78, 136.41 APE8-dihe-in -57.94, 135.93 APE8-rot-in 298.8 APE67-dihe-in -52.87, -33.29 -49.91, -51.82 APE12-dist-in 12.549 APE11-dist-in 11.378 APE10-dist-in 7.325 APE9-dist-in 3.185 None PTR321 PTR321 XRAY 2.77 0.207 0.252 E 370 340 6 0 0 0 [[159, 479]] 1.0 7z5n CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7Z5NF 135 480 763.0 3NG:501 Type1 Active DFGin 7.268 14.5 BLAminus -134.01, 179.07 56.51, 71.89 -90.03, 23.99 289.58, 70.49 -65.64, -23.07 in-in in 9.224 Saltbr-in 2.867 HRD-in -69.65, -42.1 76.58, -5.06 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.88, -177.32 APE9-dihe-na 69.42, 90.94 APE8-dihe-in -27.36, 123.58 APE8-rot-in 265.98 APE67-dihe-in -50.43, -31.45 -50.21, -44.01 APE12-dist-in 13.065 APE11-dist-in 11.252 APE10-dist-in 6.846 APE9-dist-in 3.171 None PTR321 PTR321 XRAY 2.77 0.207 0.252 F 370 346 0 0 0 0 [[159, 479]] 1.0 7z5n CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7Z5NG 137 480 763.0 3NG:501 Type1 Active DFGin 7.344 14.781 BLAminus -131.27, 177.34 58.91, 64.55 -81.55, 37.12 289.02, 78.81 -81.79, -16.85 in-in in 8.979 Saltbr-in 2.629 HRD-in -65.23, -49.26 77.2, 4.64 in-in-in SNCiii in-in ActLoopNT-in 2.719 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.89, 64.11 APE9-dihe-na -161.3, 162.4 APE8-dihe-in -70.8, 130.74 APE8-rot-in 279.54 APE67-dihe-in -57.11, -25.99 -52.9, -46.96 APE12-dist-in 12.712 APE11-dist-in 11.544 APE10-dist-in 6.759 APE9-dist-in 3.418 None PTR321 PTR321 XRAY 2.77 0.207 0.252 G 370 333 11 0 0 0 [[159, 479]] 1.0 7z5n CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8C3RA 135 480 763.0 R7O:501 Type1 Active DFGin 7.582 14.765 BLAminus -123.3, 160.97 61.95, 92.11 -99.77, 29.64 287.05, 71.45 -70.47, -16.78 in-in in 8.52 Saltbr-in 2.774 HRD-in -65.6, -46.48 78.0, 2.34 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.35, 171.73 APE9-dihe-na 71.24, 149.33 APE8-dihe-in -74.45, 145.43 APE8-rot-in 300.61 APE67-dihe-in -59.08, -27.8 -56.43, -44.81 APE12-dist-in 12.402 APE11-dist-in 11.201 APE10-dist-in 7.222 APE9-dist-in 3.222 None PTR321 PTR321 XRAY 2.06 0.187 0.209 A 370 346 0 0 0 0 [[159, 479]] 1.0 8c3r CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8C3RB 136 480 763.0 R7O:501 Type1 Active DFGin 7.136 14.811 BLAminus -123.29, 167.45 65.44, 80.19 -97.63, 28.79 287.96, 74.69 -68.15, -22.5 in-in in 8.662 Saltbr-in 2.942 HRD-in -67.34, -39.55 70.0, 7.08 in-in-in SNCiii in-in ActLoopNT-in 2.703 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.04, 166.27 APE9-dihe-na 72.62, 139.21 APE8-dihe-in -62.23, 144.37 APE8-rot-in 295.1 APE67-dihe-in -57.99, -27.22 -56.76, -45.19 APE12-dist-in 12.555 APE11-dist-in 10.994 APE10-dist-in 7.329 APE9-dist-in 3.225 None PTR321 PTR321 XRAY 2.06 0.187 0.209 B 370 345 0 0 0 0 [[159, 479]] 1.0 8c3r CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8C3GA 134 480 763.0 QS0:501 Type1 Active DFGin 7.743 15.056 BLAminus -122.4, 159.11 70.62, 87.46 -99.56, 24.8 280.34, 73.41 -66.95, -22.86 in-in in 8.66 Saltbr-in 2.906 HRD-in -63.26, -48.03 79.68, -2.67 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.78, 166.89 APE9-dihe-na 73.47, 141.67 APE8-dihe-in -65.32, 142.21 APE8-rot-in 286.57 APE67-dihe-in -55.53, -29.43 -49.01, -52.14 APE12-dist-in 13.368 APE11-dist-in 11.339 APE10-dist-in 7.622 APE9-dist-in 3.122 None PTR321 PTR321 XRAY 2.08 0.196 0.237 A 371 344 3 0 0 0 [[159, 479]] 1.0 8c3g CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8C3GB 134 480 763.0 QS0:501 Type1 Active DFGin 7.619 14.965 BLAminus -126.26, 160.88 70.82, 88.0 -100.32, 24.36 284.04, 76.33 -69.92, -22.03 in-in in 8.69 Saltbr-in 2.709 HRD-in -65.16, -43.7 77.31, -6.37 in-in-in SNCiii in-in ActLoopNT-in 2.72 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.34, 171.66 APE9-dihe-na 68.35, 154.78 APE8-dihe-in -74.32, 140.03 APE8-rot-in 274.86 APE67-dihe-in -57.14, -31.61 -51.55, -47.48 APE12-dist-in 13.897 APE11-dist-in 11.795 APE10-dist-in 7.918 APE9-dist-in 3.068 None PTR321 PTR321 XRAY 2.08 0.196 0.237 B 371 333 14 0 0 0 [[159, 479]] 1.0 8c3g CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8C3GC 134 480 763.0 QS0:502 Type1 Active DFGin 7.39 14.702 BLAminus -128.69, 158.7 71.6, 91.39 -100.86, 21.74 282.48, 82.23 -71.28, -20.67 in-in in 8.486 Saltbr-in 2.828 HRD-in -70.94, -40.51 73.81, -8.22 in-in-in SNCiii in-in ActLoopNT-in 2.715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.57, 166.28 APE9-dihe-na 71.87, 146.61 APE8-dihe-in -66.83, 145.54 APE8-rot-in 302.42 APE67-dihe-in -61.67, -26.79 -57.09, -43.66 APE12-dist-in 13.613 APE11-dist-in 11.865 APE10-dist-in 7.836 APE9-dist-in 3.181 None PTR321 PTR321 XRAY 2.08 0.196 0.237 C 371 341 6 0 0 0 [[159, 479]] 1.0 8c3g CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8C3GD 134 480 763.0 QS0:501 Type1 Active DFGin 7.385 14.915 BLAminus -133.23, 162.85 62.78, 88.13 -95.33, 26.44 290.5, 77.86 -68.41, -23.5 in-in in 8.607 Saltbr-in 2.822 HRD-in -60.07, -49.82 78.57, -2.37 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.4, 174.1 APE9-dihe-na 67.56, 148.97 APE8-dihe-in -66.35, 140.59 APE8-rot-in 265.57 APE67-dihe-in -54.42, -30.15 -57.29, -47.59 APE12-dist-in 13.746 APE11-dist-in 12.049 APE10-dist-in 7.901 APE9-dist-in 3.058 None PTR321 PTR321 XRAY 2.08 0.196 0.237 D 371 337 10 0 0 0 [[159, 479]] 1.0 8c3g CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
9FPXA 136 479 763.0 CC9:501 Type1 Active DFGin 7.639 14.564 BLAminus -128.52, -179.85 64.32, 75.88 -96.77, 27.03 289.01, 77.19 -67.47, -43.12 in-in in 8.672 Saltbr-in 2.767 HRD-in -68.22, -36.96 69.23, -0.41 in-in-in SNCiii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.19, -47.98 APE9-dihe-na -95.05, 163.26 APE8-dihe-in -63.48, 147.02 APE8-rot-in 273.59 APE67-dihe-in -53.12, -33.33 -58.72, -55.68 APE12-dist-in 12.051 APE11-dist-in 10.975 APE10-dist-in 7.128 APE9-dist-in 3.304 None PTR321 PTR321 XRAY 2.69 0.242 0.278 A 371 337 7 0 0 0 [[159, 479]] 1.0 9fpx CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
9FPXB 143 480 763.0 CC9:501 Type1 Active DFGin 7.491 14.356 BLAminus -125.11, 175.25 58.16, 79.65 -98.94, 25.54 294.99, 76.36 -62.08, -51.42 in-in in 8.96 Saltbr-in 3.042 HRD-in -68.96, -37.47 65.08, 10.01 in-in-in SNCiii in-in ActLoopNT-in 2.43 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.35, 179.3 APE9-dihe-na 69.75, 147.35 APE8-dihe-in -76.68, 135.47 APE8-rot-in 286.81 APE67-dihe-in -53.4, -25.2 -48.11, -54.23 APE12-dist-in 12.133 APE11-dist-in 11.319 APE10-dist-in 7.011 APE9-dist-in 3.215 None PTR321 PTR321 XRAY 2.69 0.242 0.278 B 371 337 1 0 0 0 [[159, 479]] 1.0 9fpx CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
2VX3A 135 481 763.0 D15:600 Type1 Active DFGin 7.177 14.936 BLAminus -117.81, 179.58 65.92, 72.63 -91.66, 22.61 288.71, 80.01 -64.63, -16.68 in-in in 9.357 Saltbr-in 2.613 HRD-in -69.18, -45.26 74.92, -7.88 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.77, 169.88 APE9-dihe-na 74.29, 146.1 APE8-dihe-in -68.67, 142.33 APE8-rot-in 277.43 APE67-dihe-in -61.53, -28.29 -54.62, -46.41 APE12-dist-in 12.499 APE11-dist-in 11.435 APE10-dist-in 6.965 APE9-dist-in 3.064 None PTR321 PTR321 XRAY 2.4 0.186 0.23 A 382 347 0 0 0 0 [[159, 479]] 1.0 2vx3 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
2VX3B 135 480 763.0 D15:600 Type1 Active DFGin 7.264 15.037 BLAminus -122.56, -178.04 63.15, 68.41 -88.18, 26.58 286.19, 82.05 -63.3, -25.27 in-in in 9.323 Saltbr-in 2.487 HRD-in -63.29, -48.28 78.74, -5.5 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.98, 169.63 APE9-dihe-na 73.35, 142.01 APE8-dihe-in -64.13, 145.91 APE8-rot-in 293.73 APE67-dihe-in -61.18, -25.64 -59.75, -45.87 APE12-dist-in 12.788 APE11-dist-in 11.481 APE10-dist-in 7.216 APE9-dist-in 3.173 None PTR321 PTR321 XRAY 2.4 0.186 0.23 B 382 341 5 0 0 0 [[159, 479]] 1.0 2vx3 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
2VX3C 135 480 763.0 D15:600 Type1 Active DFGin 7.171 15.076 BLAminus -121.44, 178.92 62.09, 79.8 -99.68, 23.42 286.42, 75.22 -71.85, -9.09 in-in in 9.284 Saltbr-in 2.559 HRD-in -69.05, -51.28 81.08, -2.28 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.91, 169.36 APE9-dihe-na 73.6, 142.61 APE8-dihe-in -69.05, 142.27 APE8-rot-in 289.71 APE67-dihe-in -57.92, -27.82 -52.31, -50.36 APE12-dist-in 12.693 APE11-dist-in 11.469 APE10-dist-in 7.054 APE9-dist-in 3.198 None PTR321 PTR321 XRAY 2.4 0.186 0.23 C 382 339 7 0 0 0 [[159, 479]] 1.0 2vx3 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
2VX3D 135 480 763.0 D15:600 Type1 Active DFGin 7.127 15.124 BLAminus -119.03, 173.28 66.12, 79.97 -97.89, 24.65 287.18, 77.93 -62.52, -22.35 in-in in 9.434 Saltbr-in 2.837 HRD-in -59.24, -53.5 80.78, -1.27 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.8, 170.17 APE9-dihe-na 73.1, 153.08 APE8-dihe-in -81.31, 142.62 APE8-rot-in 292.88 APE67-dihe-in -60.26, -27.62 -52.95, -48.14 APE12-dist-in 12.928 APE11-dist-in 11.48 APE10-dist-in 7.18 APE9-dist-in 3.148 None PTR321 PTR321 XRAY 2.4 0.186 0.23 D 382 343 3 0 0 0 [[159, 479]] 1.0 2vx3 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
2WO6A 133 481 763.0 D15:60600 Type1 Active DFGin 7.448 15.138 BLAminus -113.71, 170.1 69.22, 79.01 -93.27, 30.89 281.47, 79.67 -74.92, -25.98 in-in in 8.538 Saltbr-in 2.478 HRD-in -60.74, -47.85 77.07, -4.65 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.22, 165.87 APE9-dihe-na 75.78, 143.18 APE8-dihe-in -71.63, 143.35 APE8-rot-in 298.65 APE67-dihe-in -54.81, -27.06 -54.61, -51.13 APE12-dist-in 13.979 APE11-dist-in 11.967 APE10-dist-in 7.387 APE9-dist-in 3.275 None PTR321 PTR321 XRAY 2.5 0.19 0.229 A 382 345 4 0 0 0 [[159, 479]] 1.0 2wo6 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
2WO6B 136 480 763.0 D15:60600 Type1 Active DFGin 7.392 15.045 BLAminus -114.82, 170.21 64.99, 84.74 -96.3, 34.41 283.13, 77.19 -78.24, -22.43 in-in in 9.207 Saltbr-in 2.725 HRD-in -63.58, -44.58 74.08, -1.57 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.01, 169.27 APE9-dihe-na 76.89, 144.45 APE8-dihe-in -76.49, 136.75 APE8-rot-in 283.78 APE67-dihe-in -66.31, -25.74 -49.43, -39.9 APE12-dist-in 12.633 APE11-dist-in 11.105 APE10-dist-in 6.823 APE9-dist-in 3.096 None PTR321 PTR321 XRAY 2.5 0.19 0.229 B 382 340 5 0 0 0 [[159, 479]] 1.0 2wo6 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4AZEA 132 481 763.0 3RA:700 Type1 Active DFGin 6.953 14.616 BLAminus -137.23, 169.92 67.49, 90.44 -106.39, 23.89 283.3, 71.95 -55.61, -37.62 in-in in 9.01 Saltbr-in 2.812 HRD-in -70.04, -49.18 72.92, 15.43 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.19, 169.65 APE9-dihe-na 74.45, 134.72 APE8-dihe-in -60.37, 136.79 APE8-rot-in 289.06 APE67-dihe-in -57.82, -32.3 -48.27, -49.81 APE12-dist-in 12.265 APE11-dist-in 10.562 APE10-dist-in 6.635 APE9-dist-in 3.256 None SEP301,PTR321 SEP301,PTR321 XRAY 3.15 0.219 0.248 A 382 350 0 0 0 0 [[159, 479]] 1.0 4aze CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4AZEB 135 481 763.0 3RA:700 Type1 Active DFGin 6.924 14.613 BLAminus -138.16, 169.5 68.4, 90.42 -106.1, 24.2 283.49, 72.02 -57.21, -35.99 in-in in 9.022 Saltbr-in 2.9 HRD-in -69.57, -48.1 73.99, 12.32 in-in-in SNCiii in-in ActLoopNT-in 2.833 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.81, 169.0 APE9-dihe-na 74.6, 134.75 APE8-dihe-in -60.95, 138.61 APE8-rot-in 290.43 APE67-dihe-in -56.44, -36.37 -49.68, -48.78 APE12-dist-in 12.276 APE11-dist-in 10.559 APE10-dist-in 6.631 APE9-dist-in 3.226 None SEP301,PTR321 SEP301,PTR321 XRAY 3.15 0.219 0.248 B 382 347 0 0 0 0 [[159, 479]] 1.0 4aze CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4AZEC 132 481 763.0 3RA:700 Type1 Active DFGin 6.933 14.607 BLAminus -136.67, 171.08 67.02, 92.32 -107.7, 25.06 283.25, 71.9 -57.45, -37.58 in-in in 9.002 Saltbr-in 2.835 HRD-in -68.51, -50.21 73.5, 15.7 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.49, 169.71 APE9-dihe-na 73.57, 134.86 APE8-dihe-in -60.52, 139.24 APE8-rot-in 289.26 APE67-dihe-in -57.24, -34.82 -50.4, -48.08 APE12-dist-in 12.316 APE11-dist-in 10.569 APE10-dist-in 6.591 APE9-dist-in 3.28 None SEP301,PTR321 SEP301,PTR321 XRAY 3.15 0.219 0.248 C 382 350 0 0 0 0 [[159, 479]] 1.0 4aze CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5AIKA 134 481 763.0 AWR:900 Type1 Active DFGin 7.488 15.138 BLAminus -123.8, 165.61 68.96, 89.37 -99.53, 20.4 284.53, 79.68 -68.37, -30.16 in-in in 8.457 Saltbr-in 2.716 HRD-in -69.39, -41.54 73.14, 9.89 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.11, 166.6 APE9-dihe-na 72.45, 139.9 APE8-dihe-in -58.6, 139.24 APE8-rot-in 263.46 APE67-dihe-in -61.38, -25.4 -48.26, -51.05 APE12-dist-in 13.515 APE11-dist-in 11.757 APE10-dist-in 7.939 APE9-dist-in 3.238 None PTR321 PTR321 XRAY 2.7 0.228 0.252 A 382 345 3 0 0 0 [[159, 479]] 1.0 5aik CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5AIKB 134 481 763.0 AWR:900 Type1 Active DFGin 7.471 15.176 BLAminus -125.22, 165.11 67.89, 88.91 -100.53, 21.33 285.51, 80.4 -65.48, -31.48 in-in in 8.424 Saltbr-in 2.707 HRD-in -68.57, -40.82 71.56, 10.16 in-in-in SNCiii in-in ActLoopNT-in 2.777 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.21, 166.46 APE9-dihe-na 73.88, 141.73 APE8-dihe-in -58.72, 138.35 APE8-rot-in 264.56 APE67-dihe-in -61.35, -26.09 -50.07, -49.03 APE12-dist-in 13.527 APE11-dist-in 11.708 APE10-dist-in 7.938 APE9-dist-in 3.208 None PTR321 PTR321 XRAY 2.7 0.228 0.252 B 382 343 5 0 0 0 [[159, 479]] 1.0 5aik CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5AIKC 134 481 763.0 AWR:900 Type1 Active DFGin 7.496 15.188 BLAminus -123.03, 165.69 69.38, 87.6 -99.21, 19.82 285.24, 79.6 -64.68, -32.8 in-in in 8.455 Saltbr-in 2.713 HRD-in -68.63, -41.21 72.74, 9.64 in-in-in SNCiii in-in ActLoopNT-in 2.787 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.44, 166.36 APE9-dihe-na 71.77, 141.71 APE8-dihe-in -59.81, 140.84 APE8-rot-in 262.61 APE67-dihe-in -60.57, -26.31 -49.76, -50.14 APE12-dist-in 13.385 APE11-dist-in 11.642 APE10-dist-in 7.885 APE9-dist-in 3.217 None PTR321 PTR321 XRAY 2.7 0.228 0.252 C 382 343 5 0 0 0 [[159, 479]] 1.0 5aik CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5AIKD 134 480 763.0 AWR:900 Type1 Active DFGin 7.476 15.15 BLAminus -124.79, 165.65 68.79, 87.65 -99.81, 21.12 284.88, 80.68 -66.8, -31.32 in-in in 8.421 Saltbr-in 2.707 HRD-in -68.57, -41.65 72.65, 9.66 in-in-in SNCiii in-in ActLoopNT-in 2.78 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.19, 166.91 APE9-dihe-na 72.86, 141.73 APE8-dihe-in -58.81, 138.66 APE8-rot-in 264.48 APE67-dihe-in -59.64, -26.2 -50.08, -49.71 APE12-dist-in 13.488 APE11-dist-in 11.764 APE10-dist-in 7.955 APE9-dist-in 3.231 None PTR321 PTR321 XRAY 2.7 0.228 0.252 D 382 343 4 0 0 0 [[159, 479]] 1.0 5aik CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A4WA 136 481 763.0 QYH:501 Type1 Active DFGin 7.514 14.841 BLAminus -120.3, 168.53 72.59, 81.22 -96.63, 23.6 288.31, 80.09 -71.01, -22.42 in-in in 8.491 Saltbr-in 2.835 HRD-in -59.72, -50.21 79.8, 0.59 in-in-in SNCiii in-in ActLoopNT-in 3.003 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.05, 174.06 APE9-dihe-na 68.15, 147.74 APE8-dihe-in -68.98, 144.2 APE8-rot-in 298.89 APE67-dihe-in -63.8, -25.02 -56.72, -43.13 APE12-dist-in 9.924 APE11-dist-in 12.077 APE10-dist-in 7.536 APE9-dist-in 3.227 None PTR321 PTR321 XRAY 2.7 0.165 0.205 A 382 340 6 0 0 0 [[159, 479]] 1.0 7a4w CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A55A 136 481 763.0 QZ2:501 Type1 Active DFGin 7.451 14.684 BLAminus -119.66, 171.79 70.04, 73.01 -89.35, 24.06 289.05, 80.07 -69.14, -22.64 in-in in 8.713 Saltbr-in 2.75 HRD-in -60.62, -50.43 82.56, -1.02 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.49, 170.31 APE9-dihe-na 73.06, 145.82 APE8-dihe-in -70.98, 140.61 APE8-rot-in 304.48 APE67-dihe-in -64.49, -24.47 -51.36, -43.54 APE12-dist-in 10.05 APE11-dist-in 12.225 APE10-dist-in 7.691 APE9-dist-in 3.217 None PTR321 PTR321 XRAY 2.2 0.182 0.225 A 382 340 6 0 0 0 [[159, 479]] 1.0 7a55 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A5BA 136 481 763.0 MFR:501 Type1 Active DFGin 7.453 14.846 BLAminus -123.33, 168.55 72.72, 88.97 -105.77, 23.56 281.26, 83.72 -72.41, -22.85 in-in in 8.485 Saltbr-in 2.953 HRD-in -66.22, -48.04 76.25, -4.46 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.35, 172.6 APE9-dihe-na 68.45, 154.81 APE8-dihe-in -72.07, 143.61 APE8-rot-in 303.66 APE67-dihe-in -68.11, -19.27 -52.63, -42.7 APE12-dist-in 9.784 APE11-dist-in 11.923 APE10-dist-in 7.448 APE9-dist-in 3.103 None PTR321 PTR321 XRAY 2.6 0.155 0.192 A 382 340 6 0 0 0 [[159, 479]] 1.0 7a5b CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7ZH8A 135 482 763.0 IWU:501,IWU:503 Type1,Allosteric Active DFGin 6.93 14.485 BLAminus -122.84, 179.43 62.46, 67.96 -84.46, 26.09 290.83, 71.55 -67.12, -11.2 in-in in 8.883 Saltbr-in 2.724 HRD-in -63.87, -44.79 74.86, -8.37 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.43, 165.77 APE9-dihe-na 78.45, 153.82 APE8-dihe-in -75.88, 144.9 APE8-rot-in 282.17 APE67-dihe-in -60.66, -29.31 -54.53, -47.47 APE12-dist-in 12.842 APE11-dist-in 11.113 APE10-dist-in 7.113 APE9-dist-in 3.047 None PTR321 PTR321 XRAY 2.3 0.199 0.235 A 382 348 0 0 0 0 [[159, 479]] 1.0 7zh8 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7ZH8B 135 481 763.0 IWU:501,IWU:502 Type1,Allosteric Active DFGin 7.016 14.696 BLAminus -126.24, 176.32 61.01, 72.92 -85.71, 26.03 289.71, 74.68 -65.98, -19.69 in-in in 8.922 Saltbr-in 2.551 HRD-in -62.74, -46.92 79.26, -5.01 in-in-in SNCiii in-in ActLoopNT-in 2.776 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.66, 167.11 APE9-dihe-na 77.27, 157.6 APE8-dihe-in -78.84, 143.58 APE8-rot-in 289.38 APE67-dihe-in -64.23, -22.19 -57.38, -41.71 APE12-dist-in 12.706 APE11-dist-in 11.378 APE10-dist-in 7.012 APE9-dist-in 3.066 None PTR321 PTR321 XRAY 2.3 0.199 0.235 B 382 347 0 0 0 0 [[159, 479]] 1.0 7zh8 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7ZH8C 136 481 763.0 IWU:502,IWU:504 Type1,Allosteric Active DFGin 6.95 14.526 BLAminus -134.74, -179.56 61.5, 68.92 -87.34, 24.99 287.1, 79.14 -63.98, -23.48 in-in in 8.908 Saltbr-in 2.284 HRD-in -62.72, -47.25 75.43, -4.98 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.64, 173.03 APE9-dihe-na 68.29, 149.69 APE8-dihe-in -67.12, 144.66 APE8-rot-in 287.21 APE67-dihe-in -61.1, -29.22 -57.48, -42.67 APE12-dist-in 12.923 APE11-dist-in 11.192 APE10-dist-in 6.996 APE9-dist-in 3.16 None PTR321 PTR321 XRAY 2.3 0.199 0.235 C 382 346 0 0 0 0 [[159, 479]] 1.0 7zh8 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7ZH8D 135 480 763.0 IWU:501,IWU:502 Type1,Allosteric Active DFGin 6.962 14.615 BLAminus -123.17, -177.61 59.0, 69.45 -88.29, 28.99 287.8, 74.48 -73.6, -11.3 in-in in 8.821 Saltbr-in 2.61 HRD-in -61.94, -44.56 72.7, -0.97 in-in-in SNCiii in-in ActLoopNT-in 2.549 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.11, 172.59 APE9-dihe-na 67.75, 147.93 APE8-dihe-in -73.89, 139.89 APE8-rot-in 260.52 APE67-dihe-in -46.52, -33.56 -54.25, -52.57 APE12-dist-in 12.275 APE11-dist-in 11.283 APE10-dist-in 6.938 APE9-dist-in 3.153 None PTR321 PTR321 XRAY 2.3 0.199 0.235 D 382 346 0 0 0 0 [[159, 479]] 1.0 7zh8 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8C3QA 134 480 763.0 RUT:501 Type1.5_Back Active DFGin 7.532 14.605 BLAminus -124.23, 179.11 72.21, 75.86 -95.78, 26.15 290.44, 76.76 -62.33, -27.15 in-in in 9.176 Saltbr-in 3.215 HRD-in -66.45, -50.9 75.85, 5.78 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.82, 171.3 APE9-dihe-na 70.78, 147.49 APE8-dihe-in -69.41, 147.33 APE8-rot-in 280.79 APE67-dihe-in -56.28, -27.14 -64.52, -44.2 APE12-dist-in 12.096 APE11-dist-in 10.7 APE10-dist-in 6.537 APE9-dist-in 3.086 None PTR321 PTR321 XRAY 2.32 0.178 0.21 A 370 344 3 0 0 0 [[159, 479]] 1.0 8c3q CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8C3QB 136 480 763.0 RUT:501 Type1.5_Back Active DFGin 7.376 14.823 BLAminus -127.14, 177.53 66.16, 80.91 -99.41, 25.8 287.74, 74.6 -66.59, -26.2 in-in in 9.106 Saltbr-in 3.03 HRD-in -69.45, -45.26 72.64, 7.14 in-in-in SNCiii in-in ActLoopNT-in 2.692 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.34, 175.86 APE9-dihe-na 74.43, 169.23 APE8-dihe-in -95.61, 134.32 APE8-rot-in 284.11 APE67-dihe-in -56.76, -28.89 -40.65, -51.81 APE12-dist-in 12.117 APE11-dist-in 10.746 APE10-dist-in 6.799 APE9-dist-in 3.089 None PTR321 PTR321 XRAY 2.32 0.178 0.21 B 370 344 1 0 0 0 [[159, 479]] 1.0 8c3q CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6UIPB 136 478 763.0 Q8J:501 Type1 Inactive DFGin 6.895 14.93 ABAminus -128.46, -42.33 -94.91, 127.61 -132.24, 12.58 285.14, 81.63 -56.41, -45.59 in-in in 9.087 Saltbr-in 2.898 HRD-in -67.7, -47.87 68.18, -0.51 in-in-in SNCiii in-in ActLoopNT-in 3.091 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.31, 177.75 APE9-dihe-na 64.01, 150.34 APE8-dihe-in -71.42, 137.1 APE8-rot-in 300.33 APE67-dihe-in -57.48, -29.96 -50.84, -45.43 APE12-dist-in 12.84 APE11-dist-in 11.176 APE10-dist-in 7.15 APE9-dist-in 2.974 None PTR321 PTR321 XRAY 3.7 0.272 0.29 B 361 338 6 0 0 0 [[159, 479]] 1.0 6uip CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6UIPC 131 477 763.0 Q8J:501 Type1 Inactive DFGin 6.957 14.584 ABAminus -128.48, -41.69 -94.89, 138.63 -139.05, 93.64 283.54, 77.23 -157.81, 999.0 in-in in 8.695 Saltbr-in 2.66 HRD-in -68.31, -47.09 68.76, -0.11 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na -122.81, -42.23 APE9-dihe-na -85.49, 157.66 APE8-dihe-in -67.92, 135.09 APE8-rot-out 172.73 APE67-dihe-in -59.1, -31.97 -53.15, -45.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.046 None PTR321 PTR321 XRAY 3.7 0.272 0.29 C 361 306 39 0 0 9 [[159, 479]] 1.0 6uip CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A4OB 134 481 763.0 ANP:501 ATPlike Inactive DFGin 7.223 15.047 BLAminus -127.4, 170.29 72.8, 80.08 -93.18, 24.5 286.73, 76.67 -71.46, -26.03 in-in in 8.365 Saltbr-in 2.797 HRD-in -57.9, -49.71 71.19, 2.83 in-in-out SNCiio in-out ActLoopNT-in 2.84 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -84.65, 164.16 APE9-dihe-na 75.07, 150.77 APE8-dihe-in -68.35, 138.34 APE8-rot-in 298.16 APE67-dihe-in -63.89, -24.74 -46.52, -48.39 APE12-dist-out 14.097 APE11-dist-in 11.896 APE10-dist-in 7.537 APE9-dist-in 3.028 None PTR321 PTR321 XRAY 1.9 0.18 0.203 B 382 341 7 0 0 0 [[159, 479]] 1.0 7a4o CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EILC 135 479 763.0 No_ligand No_ligand Inactive DFGin 7.37 15.158 BLAminus -131.05, 169.12 64.27, 85.03 -103.64, 28.05 281.44, 77.48 -71.23, -40.12 in-in in 8.643 Saltbr-in 2.937 HRD-in -68.33, -38.56 64.92, 12.92 in-in-out SNCiio in-out ActLoopNT-in 2.888 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -130.34, 174.88 APE9-dihe-na 62.38, 154.4 APE8-dihe-in -77.48, 142.58 APE8-rot-in 292.83 APE67-dihe-in -52.78, -22.59 -54.68, -54.7 APE12-dist-out 14.139 APE11-dist-in 11.754 APE10-dist-out 8.119 APE9-dist-in 3.283 None PTR321 PTR321 XRAY 2.465 0.213 0.254 C 368 333 12 0 0 0 [[159, 479]] 1.0 6eil CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A52A 148 479 763.0 QYB:60501 Type1 Inactive DFGin 7.317 14.879 BLAminus -123.16, 170.09 65.81, 84.07 -98.75, 23.74 289.83, 75.25 -64.25, -28.4 in-in in 8.518 Saltbr-in 2.706 HRD-in -61.91, -47.73 72.05, 4.02 in-in-out SNCiio in-out ActLoopNT-in 2.84 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.5, 160.85 APE9-dihe-na 74.97, 147.38 APE8-dihe-in -70.98, 136.41 APE8-rot-out 187.37 APE67-dihe-in -56.3, -29.72 -45.33, -55.66 APE12-dist-in 12.302 APE11-dist-in 10.999 APE10-dist-in 7.285 APE9-dist-in 3.099 None PTR321 PTR321 XRAY 2.1 0.167 0.206 A 355 329 3 0 0 0 [[159, 479]] 1.0 7a52 CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7OY6C 135 481 763.0 39I:501 Type1 Inactive DFGin 7.648 15.4 BLAminus -125.83, 168.21 66.48, 82.31 -94.71, 17.96 280.2, 86.53 -72.92, -24.78 in-in in 8.812 Saltbr-in 3.231 HRD-in -68.26, -38.56 68.22, 7.69 in-in-out SNCiio in-out ActLoopNT-in 2.664 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -109.61, 169.12 APE9-dihe-na 78.1, 158.02 APE8-dihe-in -72.9, 138.3 APE8-rot-out 215.64 APE67-dihe-in -58.63, -31.51 -47.01, -53.58 APE12-dist-out 14.468 APE11-dist-in 12.493 APE10-dist-out 8.058 APE9-dist-in 3.359 None PTR321 PTR321 XRAY 2.38 0.202 0.27 C 359 343 4 0 0 0 [[159, 479]] 1.0 7oy6 CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJVA 148 481 763.0 RKK:60501 Type1 Inactive DFGin 7.083 14.724 BLAminus -123.61, 170.03 70.85, 87.15 -98.76, 25.47 292.1, 75.69 -58.41, -34.3 in-in in 8.669 Saltbr-in 2.489 HRD-in -60.17, -50.82 77.68, 3.17 in-in-out SNCiio in-out ActLoopNT-in 2.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.87, 159.47 APE9-dihe-na 70.75, 141.67 APE8-dihe-in -65.64, 133.79 APE8-rot-out 171.55 APE67-dihe-in -58.95, -30.68 -50.41, -48.06 APE12-dist-in 11.625 APE11-dist-in 10.455 APE10-dist-in 6.904 APE9-dist-in 3.063 None PTR321 PTR321 XRAY 2.1 0.182 0.219 A 359 330 4 0 0 0 [[159, 479]] 1.0 7ajv CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJVB 148 481 763.0 RKK:60501 Type1 Inactive DFGin 7.184 14.628 BLAminus -117.14, 169.86 69.68, 90.8 -103.92, 27.7 282.23, 78.07 -72.14, -22.36 in-in in 8.618 Saltbr-in 2.757 HRD-in -62.69, -52.71 75.84, 3.99 in-in-out SNCiio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -148.21, 169.45 APE9-dihe-na 77.96, 139.9 APE8-dihe-in -73.65, 144.05 APE8-rot-out 83.51 APE67-dihe-in -59.27, -27.74 -53.72, -47.01 APE12-dist-in 12.782 APE11-dist-in 10.832 APE10-dist-in 6.539 APE9-dist-in 3.096 None PTR321 PTR321 XRAY 2.1 0.182 0.219 B 359 327 7 0 0 0 [[159, 479]] 1.0 7ajv CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJYA 148 481 763.0 RKZ:60501 Type1 Inactive DFGin 7.153 14.575 BLAminus -120.41, 167.48 78.93, 86.44 -103.86, 24.23 289.2, 84.36 -65.73, -34.02 in-in in 8.58 Saltbr-in 2.68 HRD-in -65.87, -47.05 67.93, 7.7 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.54, 163.03 APE9-dihe-na 66.78, 135.8 APE8-dihe-in -55.89, 133.22 APE8-rot-out 187.97 APE67-dihe-in -62.45, -26.31 -51.83, -46.65 APE12-dist-in 11.587 APE11-dist-in 10.706 APE10-dist-in 7.145 APE9-dist-in 3.166 None PTR321 PTR321 XRAY 2.2 0.185 0.225 A 359 330 4 0 0 0 [[159, 479]] 1.0 7ajy CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AJYB 148 481 763.0 RKZ:60501 Type1 Inactive DFGin 7.296 14.556 BLAminus -121.44, 168.83 70.7, 88.53 -103.39, 25.09 284.65, 82.01 -78.66, -10.84 in-in in 8.732 Saltbr-in 2.67 HRD-in -63.4, -50.81 70.51, 11.76 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -148.9, 170.84 APE9-dihe-na 74.85, 141.66 APE8-dihe-in -63.58, 131.13 APE8-rot-out 201.85 APE67-dihe-in -63.09, -26.02 -42.21, -47.55 APE12-dist-in 12.959 APE11-dist-in 11.061 APE10-dist-in 6.961 APE9-dist-in 3.372 None PTR321 PTR321 XRAY 2.2 0.185 0.225 B 359 323 11 0 0 0 [[159, 479]] 1.0 7ajy CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AK2A 148 481 763.0 RHH:60501 Type1 Inactive DFGin 7.291 14.851 BLAminus -115.74, 169.98 74.14, 90.39 -102.75, 24.02 288.48, 76.67 -68.21, -33.16 in-in in 8.772 Saltbr-in 2.761 HRD-in -65.68, -50.14 75.59, 4.1 in-in-out SNCiio in-out ActLoopNT-in 2.874 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.73, 160.37 APE9-dihe-na 71.52, 143.92 APE8-dihe-in -64.68, 134.05 APE8-rot-out 173.39 APE67-dihe-in -55.51, -27.41 -48.64, -56.18 APE12-dist-in 11.739 APE11-dist-in 10.424 APE10-dist-in 6.918 APE9-dist-in 3.112 None PTR321 PTR321 XRAY 2.1 0.198 0.231 A 359 331 3 0 0 0 [[159, 479]] 1.0 7ak2 CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AK2B 148 481 763.0 RHH:60501 Type1 Inactive DFGin 7.283 14.688 BLAminus -117.62, 169.19 72.17, 91.09 -105.5, 27.65 285.34, 74.8 -80.26, -16.76 in-in in 8.738 Saltbr-in 2.729 HRD-in -64.18, -49.57 76.66, 4.04 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.09, 173.48 APE9-dihe-na 74.34, 146.62 APE8-dihe-in -67.4, 134.77 APE8-rot-out 184.21 APE67-dihe-in -56.53, -28.03 -46.83, -54.27 APE12-dist-in 12.704 APE11-dist-in 11.103 APE10-dist-in 6.668 APE9-dist-in 3.152 None PTR321 PTR321 XRAY 2.1 0.198 0.231 B 359 327 7 0 0 0 [[159, 479]] 1.0 7ak2 CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AKAA 148 481 763.0 RK2:60501 Type1 Inactive DFGin 7.121 14.683 BLAminus -118.64, 167.89 71.85, 90.88 -104.61, 26.29 284.62, 77.32 -66.04, -26.17 in-in in 8.674 Saltbr-in 2.718 HRD-in -64.96, -49.4 75.94, 3.16 in-in-out SNCiio in-out ActLoopNT-in 2.783 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -148.73, 171.65 APE9-dihe-na 73.64, 144.05 APE8-dihe-in -67.38, 137.53 APE8-rot-out 177.41 APE67-dihe-in -59.7, -26.08 -53.2, -48.16 APE12-dist-in 12.846 APE11-dist-in 11.047 APE10-dist-in 6.727 APE9-dist-in 3.203 None PTR321 PTR321 XRAY 1.9 0.174 0.211 A 359 327 7 0 0 0 [[159, 479]] 1.0 7aka CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AKAB 148 481 763.0 RK2:60501 Type1 Inactive DFGin 7.167 14.793 BLAminus -121.95, 166.05 77.1, 90.48 -104.52, 21.8 284.24, 85.51 -65.0, -33.17 in-in in 8.634 Saltbr-in 2.65 HRD-in -66.63, -48.77 76.89, 1.39 in-in-out SNCiio in-out ActLoopNT-in 2.918 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.86, 162.5 APE9-dihe-na 69.1, 142.46 APE8-dihe-in -64.79, 134.35 APE8-rot-out 179.34 APE67-dihe-in -57.61, -31.09 -48.59, -49.25 APE12-dist-in 11.967 APE11-dist-in 10.697 APE10-dist-in 6.986 APE9-dist-in 3.067 None PTR321 PTR321 XRAY 1.9 0.174 0.211 B 359 330 4 0 0 0 [[159, 479]] 1.0 7aka CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AKBA 148 481 763.0 RJZ:60501 Type1 Inactive DFGin 7.213 14.196 BLAminus -124.09, -178.78 64.16, 81.03 -98.47, 34.82 287.29, 82.14 -91.53, -10.23 in-in in 8.413 Saltbr-in 2.371 HRD-in -60.25, -38.91 64.29, 1.37 in-in-out SNCiio in-out ActLoopNT-in 2.689 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.85, 174.48 APE9-dihe-na 78.85, 161.11 APE8-dihe-in -81.8, 138.37 APE8-rot-out 193.17 APE67-dihe-in -52.47, -29.53 -48.51, -57.21 APE12-dist-in 12.559 APE11-dist-in 10.708 APE10-dist-in 6.026 APE9-dist-in 2.937 None PTR321 PTR321 XRAY 2.8 0.197 0.248 A 359 327 7 0 0 0 [[159, 479]] 1.0 7akb CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AKBB 148 481 763.0 RJZ:60501 Type1 Inactive DFGin 7.114 14.481 BLAminus -126.85, -177.09 63.55, 78.5 -99.69, 38.47 289.46, 82.22 -88.73, -23.7 in-in in 8.506 Saltbr-in 2.46 HRD-in -57.16, -39.4 67.41, 4.61 in-in-out SNCiio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.81, 161.1 APE9-dihe-na 75.42, 163.85 APE8-dihe-in -80.4, 143.9 APE8-rot-out 185.64 APE67-dihe-in -56.87, -37.37 -45.64, -60.47 APE12-dist-in 11.599 APE11-dist-in 10.648 APE10-dist-in 6.659 APE9-dist-in 2.962 None PTR321 PTR321 XRAY 2.8 0.197 0.248 B 359 329 5 0 0 0 [[159, 479]] 1.0 7akb CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AKEA 148 481 763.0 RK8:60501 Type1 Inactive DFGin 6.963 14.696 BLAminus -124.29, 171.29 66.05, 88.52 -103.72, 32.03 286.65, 86.84 -69.65, -28.4 in-in in 8.657 Saltbr-in 2.74 HRD-in -55.46, -52.04 76.49, -6.74 in-in-out SNCiio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.97, 172.85 APE9-dihe-na 70.76, 139.43 APE8-dihe-in -62.48, 134.14 APE8-rot-out 223.94 APE67-dihe-in -56.1, -32.56 -47.63, -48.41 APE12-dist-in 12.591 APE11-dist-in 10.85 APE10-dist-in 6.827 APE9-dist-in 3.233 None PTR321 PTR321 XRAY 2.3 0.23 0.284 A 359 326 8 0 0 0 [[159, 479]] 1.0 7ake CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7AKEB 148 481 763.0 RK8:60501 Type1 Inactive DFGin 6.962 14.536 BLAminus -123.67, 174.51 70.81, 90.54 -105.83, 23.0 281.74, 93.32 -67.08, -29.7 in-in in 8.426 Saltbr-in 2.881 HRD-in -57.75, -50.61 73.65, -0.98 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.84, 158.68 APE9-dihe-na 73.04, 138.35 APE8-dihe-in -54.72, 130.03 APE8-rot-out 183.62 APE67-dihe-in -61.07, -29.87 -52.21, -41.09 APE12-dist-in 11.72 APE11-dist-in 10.621 APE10-dist-in 6.908 APE9-dist-in 2.993 None PTR321 PTR321 XRAY 2.3 0.23 0.284 B 359 329 5 0 0 0 [[159, 479]] 1.0 7ake CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4MQ2D 135 480 763.0 2C4:501 Type1 Inactive DFGin 7.123 14.677 BLAminus -125.93, 172.67 67.54, 75.32 -95.86, 30.17 291.65, 80.25 -78.68, -5.86 in-in in 8.779 Saltbr-in 2.752 HRD-in -62.52, -51.42 84.63, -0.78 in-in-out SNCiio in-out ActLoopNT-in 2.702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.81, 169.31 APE9-dihe-na 78.64, 158.51 APE8-dihe-in -88.72, 136.22 APE8-rot-out 152.13 APE67-dihe-in -61.7, -23.39 -43.42, -54.44 APE12-dist-in 13.722 APE11-dist-in 11.548 APE10-dist-in 7.582 APE9-dist-in 2.926 None PTR321 PTR321 XRAY 2.8 0.193 0.258 D 361 330 16 0 0 0 [[159, 479]] 1.0 4mq2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
8R8EA 135 481 763.0 YOX:501 Type1 Inactive DFGin 7.024 14.505 BLAminus -129.01, 171.95 62.59, 74.26 -89.71, 28.71 287.29, 75.01 -75.72, -10.22 in-in in 8.616 Saltbr-in 2.892 HRD-in -63.02, -47.54 76.3, -2.75 in-in-out SNCiio in-out ActLoopNT-in 2.91 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.31, 169.2 APE9-dihe-na 75.21, 146.05 APE8-dihe-in -69.06, 139.75 APE8-rot-out 193.55 APE67-dihe-in -59.48, -26.23 -55.55, -45.75 APE12-dist-in 12.641 APE11-dist-in 11.084 APE10-dist-in 6.734 APE9-dist-in 3.115 None PTR321 PTR321 XRAY 2.22 0.2 0.234 A 361 347 0 0 0 0 [[159, 479]] 1.0 8r8e CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7FHSA 134 481 763.0 4VZ:501 Type1 Inactive DFGin 7.241 14.926 BLAminus -121.39, 176.07 62.5, 85.89 -99.63, 18.4 279.74, 77.39 -67.82, -18.09 in-in in 8.534 Saltbr-in 2.505 HRD-in -59.16, -48.2 82.44, -2.99 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -129.74, 161.14 APE9-dihe-na 76.96, 152.88 APE8-dihe-in -66.51, 139.46 APE8-rot-in 276.14 APE67-dihe-in -65.33, -20.38 -53.89, -45.41 APE12-dist-out 14.124 APE11-dist-in 12.105 APE10-dist-out 8.132 APE9-dist-in 3.11 None PTR321 PTR321 XRAY 2.42 0.234 0.275 A 361 343 5 0 0 0 [[159, 479]] 1.0 7fhs CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7FHSC 134 480 763.0 4VZ:501 Type1 Inactive DFGin 7.147 14.803 BLAminus -122.76, 175.78 63.26, 85.37 -100.76, 19.54 285.72, 82.11 -73.67, -2.97 in-in in 8.844 Saltbr-in 2.717 HRD-in -56.19, -50.9 88.82, -2.51 in-in-out SNCiio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -138.77, 162.39 APE9-dihe-na 77.37, 153.1 APE8-dihe-in -64.98, 135.39 APE8-rot-in 268.68 APE67-dihe-in -55.6, -25.7 -46.74, -55.19 APE12-dist-in 13.909 APE11-dist-in 11.996 APE10-dist-out 8.024 APE9-dist-in 3.256 None PTR321 PTR321 XRAY 2.42 0.234 0.275 C 361 341 6 0 0 0 [[159, 479]] 1.0 7fhs CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7FHSD 134 480 763.0 4VZ:501 Type1 Inactive DFGin 7.411 15.065 BLAminus -127.1, 176.87 62.95, 73.78 -97.03, 21.7 278.97, 80.32 -71.98, -32.85 in-in in 8.797 Saltbr-in 2.973 HRD-in -62.79, -46.25 79.63, -0.41 in-in-out SNCiio in-out ActLoopNT-in 2.734 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -142.76, 171.2 APE9-dihe-na 70.9, 168.34 APE8-dihe-in -89.11, 136.94 APE8-rot-in 273.67 APE67-dihe-in -56.34, -27.28 -43.9, -54.58 APE12-dist-out 14.334 APE11-dist-in 11.899 APE10-dist-out 8.219 APE9-dist-in 3.105 None PTR321 PTR321 XRAY 2.42 0.234 0.275 D 361 342 5 0 0 0 [[159, 479]] 1.0 7fhs CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7FHTA 134 481 763.0 4WD:501 Type1 Inactive DFGin 7.385 15.04 BLAminus -115.56, 172.1 66.07, 83.84 -100.52, 20.7 283.28, 78.58 -68.54, -23.03 in-in in 8.7 Saltbr-in 3.285 HRD-in -57.68, -43.02 74.5, -0.17 in-in-out SNCiio in-out ActLoopNT-in 2.768 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -135.55, 163.58 APE9-dihe-na 69.38, 153.5 APE8-dihe-in -68.25, 140.14 APE8-rot-in 282.31 APE67-dihe-in -63.83, -23.96 -47.13, -50.62 APE12-dist-in 13.845 APE11-dist-in 12.051 APE10-dist-out 8.165 APE9-dist-in 3.074 None PTR321 PTR321 XRAY 2.68 0.191 0.249 A 361 343 5 0 0 0 [[159, 479]] 1.0 7fht CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7FHTB 134 480 763.0 4WD:501 Type1 Inactive DFGin 7.552 14.875 BLAminus -130.16, 173.47 60.71, 76.23 -98.42, 21.02 279.61, 81.43 -74.75, -28.83 in-in in 8.627 Saltbr-in 2.693 HRD-in -57.11, -44.93 77.29, 4.6 in-in-out SNCiio in-out ActLoopNT-in 2.833 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -136.63, 166.07 APE9-dihe-na 72.34, 153.51 APE8-dihe-in -70.32, 130.86 APE8-rot-in 279.96 APE67-dihe-in -61.47, -23.44 -50.08, -46.31 APE12-dist-in 13.847 APE11-dist-in 11.829 APE10-dist-out 8.0 APE9-dist-in 3.279 None PTR321 PTR321 XRAY 2.68 0.191 0.249 B 361 341 6 0 0 0 [[159, 479]] 1.0 7fht CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7FHTC 134 480 763.0 4WD:501 Type1 Inactive DFGin 7.372 15.027 BLAminus -125.03, 174.37 63.18, 83.49 -99.9, 20.78 282.36, 79.78 -79.83, -7.76 in-in in 8.723 Saltbr-in 3.03 HRD-in -55.31, -47.7 76.16, 8.53 in-in-out SNCiio in-out ActLoopNT-in 3.021 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -126.03, 164.79 APE9-dihe-na 71.34, 164.59 APE8-dihe-in -70.74, 135.69 APE8-rot-in 297.13 APE67-dihe-in -61.65, -39.99 -48.8, -48.72 APE12-dist-out 14.132 APE11-dist-in 11.947 APE10-dist-out 8.075 APE9-dist-in 3.185 None PTR321 PTR321 XRAY 2.68 0.191 0.249 C 361 341 6 0 0 0 [[159, 479]] 1.0 7fht CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7FHTD 134 480 763.0 4WD:501 Type1 Inactive DFGin 7.413 15.13 BLAminus -127.5, 171.04 65.84, 77.76 -97.3, 15.13 281.72, 82.6 -61.5, -43.31 in-in in 8.663 Saltbr-in 2.595 HRD-in -56.98, -47.37 76.71, 7.39 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -125.8, 168.64 APE9-dihe-na 68.47, 157.81 APE8-dihe-in -75.05, 138.24 APE8-rot-in 287.07 APE67-dihe-in -63.35, -29.18 -50.59, -48.07 APE12-dist-out 14.251 APE11-dist-in 12.098 APE10-dist-out 8.34 APE9-dist-in 3.344 None PTR321 PTR321 XRAY 2.68 0.191 0.249 D 361 342 5 0 0 0 [[159, 479]] 1.0 7fht CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
3ANQA 134 481 763.0 EHB:1 Type1 Inactive DFGin 7.428 15.033 BLAminus -121.67, -179.92 58.78, 88.75 -108.07, 22.93 278.63, 78.12 -73.99, -18.87 in-in in 8.689 Saltbr-in 2.68 HRD-in -53.82, -46.32 72.12, 1.71 in-in-out SNCiio in-out ActLoopNT-in 2.676 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -134.05, 156.97 APE9-dihe-na 80.08, 156.96 APE8-dihe-in -74.85, 138.03 APE8-rot-in 277.08 APE67-dihe-in -54.91, -29.37 -41.62, -56.78 APE12-dist-in 13.847 APE11-dist-in 11.843 APE10-dist-out 8.098 APE9-dist-in 3.321 None PTR321 PTR321 XRAY 2.6 0.236 0.27 A 368 343 5 0 0 0 [[159, 479]] 1.0 3anq CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
3ANQB 133 481 763.0 EHB:1 Type1 Inactive DFGin 7.435 15.059 BLAminus -120.5, 177.48 60.82, 88.34 -107.39, 25.34 279.32, 79.44 -76.35, -18.64 in-in in 8.777 Saltbr-in 2.628 HRD-in -52.09, -40.38 68.1, -0.17 in-in-out SNCiio in-out ActLoopNT-in 3.565 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -110.82, 170.49 APE9-dihe-na 72.23, 154.86 APE8-dihe-in -73.28, 139.58 APE8-rot-in 273.53 APE67-dihe-in -54.53, -27.07 -43.45, -57.9 APE12-dist-out 14.259 APE11-dist-in 12.132 APE10-dist-out 8.046 APE9-dist-in 3.354 None PTR321 PTR321 XRAY 2.6 0.236 0.27 B 368 344 5 0 0 0 [[159, 479]] 1.0 3anq CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
3ANQC 134 481 763.0 EHB:1 Type1 Inactive DFGin 7.463 15.221 BLAminus -119.05, 176.81 62.43, 87.36 -107.94, 27.53 279.33, 76.42 -77.11, -19.63 in-in in 8.714 Saltbr-in 2.613 HRD-in -51.7, -39.15 66.16, -1.22 in-in-out SNCiio in-out ActLoopNT-in 3.544 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -111.74, 164.15 APE9-dihe-na 79.15, 156.09 APE8-dihe-in -74.1, 139.85 APE8-rot-in 275.2 APE67-dihe-in -53.52, -28.49 -43.27, -57.57 APE12-dist-in 13.925 APE11-dist-in 12.218 APE10-dist-out 8.167 APE9-dist-in 3.38 None PTR321 PTR321 XRAY 2.6 0.236 0.27 C 368 341 7 0 0 0 [[159, 479]] 1.0 3anq CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
3ANQD 136 479 763.0 EHB:1 Type1 Inactive DFGin 7.594 15.139 BLAminus -117.59, 176.99 61.44, 86.46 -106.43, 25.3 279.19, 78.64 -77.29, -17.82 in-in in 8.733 Saltbr-in 2.587 HRD-in -55.98, -44.97 70.33, -1.13 in-in-out SNCiio in-out ActLoopNT-in 3.321 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -131.55, 165.5 APE9-dihe-na 73.05, 156.06 APE8-dihe-in -74.09, 138.2 APE8-rot-in 274.37 APE67-dihe-in -57.04, -27.51 -41.5, -55.11 APE12-dist-in 13.917 APE11-dist-in 12.097 APE10-dist-out 8.168 APE9-dist-in 3.283 None PTR321 PTR321 XRAY 2.6 0.236 0.27 D 368 335 9 0 0 0 [[159, 479]] 1.0 3anq CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
3ANRB 133 481 763.0 HRM:1 Type1 Inactive DFGin 7.455 14.931 BLAminus -127.37, 175.29 64.18, 86.03 -102.43, 22.55 283.14, 80.72 -64.64, -20.73 in-in in 8.733 Saltbr-in 2.866 HRD-in -58.01, -41.76 68.55, -4.63 in-in-out SNCiio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -113.3, 162.51 APE9-dihe-na 75.38, 151.66 APE8-dihe-in -71.98, 142.21 APE8-rot-in 293.97 APE67-dihe-in -54.5, -26.35 -45.44, -54.76 APE12-dist-in 13.749 APE11-dist-in 11.894 APE10-dist-out 8.014 APE9-dist-in 3.315 None PTR321 PTR321 XRAY 2.6 0.232 0.264 B 368 343 6 0 0 0 [[159, 479]] 1.0 3anr CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
3ANRC 134 481 763.0 HRM:1 Type1 Inactive DFGin 7.352 14.825 BLAminus -127.39, 175.73 63.91, 86.99 -105.92, 24.64 282.96, 79.27 -68.52, -18.05 in-in in 8.72 Saltbr-in 2.964 HRD-in -60.25, -41.86 68.21, -2.43 in-in-out SNCiio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -115.38, 158.82 APE9-dihe-na 80.57, 155.21 APE8-dihe-in -73.66, 142.81 APE8-rot-in 291.66 APE67-dihe-in -55.43, -28.06 -45.81, -53.64 APE12-dist-out 14.213 APE11-dist-in 12.115 APE10-dist-out 8.258 APE9-dist-in 3.335 None PTR321 PTR321 XRAY 2.6 0.232 0.264 C 368 338 10 0 0 0 [[159, 479]] 1.0 3anr CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
3ANRD 134 479 763.0 HRM:1 Type1 Inactive DFGin 7.439 14.887 BLAminus -126.79, 174.71 64.81, 86.52 -103.95, 22.81 283.21, 80.12 -67.2, -17.95 in-in in 8.734 Saltbr-in 2.974 HRD-in -61.66, -39.95 66.39, -3.38 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -134.79, 162.98 APE9-dihe-na 75.68, 154.5 APE8-dihe-in -74.59, 142.8 APE8-rot-in 292.67 APE67-dihe-in -57.39, -25.31 -44.77, -54.21 APE12-dist-out 14.035 APE11-dist-in 12.145 APE10-dist-out 8.165 APE9-dist-in 3.245 None PTR321 PTR321 XRAY 2.6 0.232 0.264 D 368 341 5 0 0 0 [[159, 479]] 1.0 3anr CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4NCTA 134 480 763.0 2K2:501 Type1 Inactive DFGin 7.45 15.223 BLAminus -119.55, 166.32 66.7, 85.69 -102.67, 26.83 290.37, 74.07 -64.21, -35.16 in-in in 8.649 Saltbr-in 2.708 HRD-in -61.53, -41.99 82.27, -8.19 in-in-out SNCiio in-out ActLoopNT-in 3.351 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -139.9, 164.55 APE9-dihe-na 71.96, 159.44 APE8-dihe-in -83.39, 140.05 APE8-rot-in 288.68 APE67-dihe-in -54.11, -34.74 -49.22, -50.15 APE12-dist-out 14.148 APE11-dist-in 11.947 APE10-dist-out 8.466 APE9-dist-in 3.233 None PTR321 PTR321 XRAY 2.597 0.21 0.249 A 368 342 5 0 0 0 [[159, 479]] 1.0 4nct CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4NCTB 133 480 763.0 2K2:501 Type1 Inactive DFGin 7.537 15.483 BLAminus -112.81, 170.12 65.22, 81.69 -98.56, 30.84 285.57, 81.33 -75.02, -33.69 in-in in 8.788 Saltbr-in 2.746 HRD-in -63.66, -42.9 78.55, 1.57 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -129.36, 161.46 APE9-dihe-na 75.46, 146.38 APE8-dihe-in -68.35, 143.08 APE8-rot-in 284.05 APE67-dihe-in -64.51, -32.58 -57.82, -38.26 APE12-dist-out 14.378 APE11-dist-in 12.147 APE10-dist-out 8.615 APE9-dist-in 3.255 None PTR321 PTR321 XRAY 2.597 0.21 0.249 B 368 334 14 0 0 0 [[159, 479]] 1.0 4nct CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4NCTC 134 479 763.0 2K2:501 Type1 Inactive DFGin 7.716 15.479 BLAminus -129.64, 158.78 69.37, 79.12 -97.74, 33.39 284.73, 80.36 -86.72, -36.3 in-in in 8.64 Saltbr-in 2.724 HRD-in -62.5, -46.61 84.64, -8.34 in-in-out SNCiio in-out ActLoopNT-in 3.262 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -141.23, 169.47 APE9-dihe-na 67.55, 148.75 APE8-dihe-in -69.0, 145.46 APE8-rot-in 286.67 APE67-dihe-in -54.3, -28.09 -54.21, -53.36 APE12-dist-out 14.259 APE11-dist-in 12.041 APE10-dist-out 8.519 APE9-dist-in 3.205 None SEP301,PTR321 SEP301,PTR321 XRAY 2.597 0.21 0.249 C 368 341 5 0 0 0 [[159, 479]] 1.0 4nct CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
4NCTD 134 480 763.0 2K2:501 Type1 Inactive DFGin 7.679 15.463 BLAminus -116.8, 164.71 65.44, 83.98 -98.76, 30.67 288.35, 84.66 -82.45, -24.84 in-in in 8.59 Saltbr-in 2.683 HRD-in -56.14, -45.28 80.34, 2.84 in-in-out SNCiio in-out ActLoopNT-in 3.216 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -143.29, 160.78 APE9-dihe-na 73.56, 144.01 APE8-dihe-in -64.76, 138.99 APE8-rot-in 292.07 APE67-dihe-in -62.66, -32.93 -50.17, -43.53 APE12-dist-out 14.251 APE11-dist-in 12.008 APE10-dist-out 8.504 APE9-dist-in 3.31 None PTR321 PTR321 XRAY 2.597 0.21 0.249 D 368 332 15 0 0 0 [[159, 479]] 1.0 4nct CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A3XA 134 481 763.0 QIV:1482 Type1 Inactive DFGin 7.664 15.187 BLAminus -121.3, 168.45 66.25, 87.13 -106.05, 27.07 283.2, 80.21 -83.81, -17.62 in-in in 8.617 Saltbr-in 2.997 HRD-in -59.25, -48.79 80.55, -0.05 in-in-out SNCiio in-out ActLoopNT-in 3.11 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -138.85, 162.88 APE9-dihe-na 69.36, 143.48 APE8-dihe-in -71.67, 143.32 APE8-rot-in 287.54 APE67-dihe-in -58.85, -26.94 -58.65, -43.64 APE12-dist-in 13.952 APE11-dist-in 12.011 APE10-dist-out 8.258 APE9-dist-in 3.21 None PTR321 PTR321 XRAY 2.26 0.236 0.259 A 368 343 5 0 0 0 [[159, 479]] 1.0 5a3x CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A3XB 133 481 763.0 QIV:1482 Type1 Inactive DFGin 7.772 15.505 BLAminus -125.81, 167.9 65.94, 85.46 -101.51, 31.91 279.0, 78.69 -86.09, -27.09 in-in in 8.599 Saltbr-in 2.745 HRD-in -56.46, -45.32 74.34, 3.15 in-in-out SNCiio in-out ActLoopNT-in 2.725 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -137.85, 164.62 APE9-dihe-na 69.98, 148.5 APE8-dihe-in -66.5, 143.45 APE8-rot-in 290.78 APE67-dihe-in -60.87, -33.02 -55.76, -43.48 APE12-dist-out 14.034 APE11-dist-in 11.882 APE10-dist-out 8.292 APE9-dist-in 3.258 None PTR321 PTR321 XRAY 2.26 0.236 0.259 B 368 341 8 0 0 0 [[159, 479]] 1.0 5a3x CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A3XC 134 481 763.0 QIV:1482 Type1 Inactive DFGin 7.235 14.805 BLAminus -120.77, 156.43 72.71, 88.81 -105.04, 42.02 290.66, 77.33 -99.01, -30.56 in-in in 8.549 Saltbr-in 2.645 HRD-in -62.04, -42.75 76.63, -18.75 in-in-out SNCiio in-out ActLoopNT-in 2.77 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -123.59, -60.32 APE9-dihe-na -74.24, 162.28 APE8-dihe-in -68.19, 134.61 APE8-rot-in 295.26 APE67-dihe-in -59.28, -25.8 -56.62, -43.45 APE12-dist-in 13.971 APE11-dist-in 12.104 APE10-dist-out 8.003 APE9-dist-in 3.467 None PTR321 PTR321 XRAY 2.26 0.236 0.259 C 368 334 14 0 0 0 [[159, 479]] 1.0 5a3x CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A3XD 134 480 763.0 QIV:1481 Type1 Inactive DFGin 7.745 15.107 BLAminus -112.42, 164.72 67.39, 90.55 -104.31, 19.84 285.07, 76.07 -77.1, -18.41 in-in in 8.438 Saltbr-in 2.756 HRD-in -55.52, -51.58 81.21, 8.94 in-in-out SNCiio in-out ActLoopNT-in 3.003 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -143.8, 163.41 APE9-dihe-na 70.65, 146.94 APE8-dihe-in -69.56, 144.9 APE8-rot-in 290.59 APE67-dihe-in -57.48, -32.7 -57.78, -42.42 APE12-dist-out 14.424 APE11-dist-in 12.129 APE10-dist-out 8.513 APE9-dist-in 3.22 None PTR321 PTR321 XRAY 2.26 0.236 0.259 D 368 332 15 0 0 0 [[159, 479]] 1.0 5a3x CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4EC 134 473 763.0 7QQ:1475 Type1 Inactive DFGin 7.237 14.787 BLAminus -138.1, 157.66 68.63, 87.31 -107.74, 30.93 287.87, 90.33 -77.47, -44.69 in-out in 8.675 Saltbr-out 4.117 HRD-in -57.3, -42.31 66.35, 18.38 out-in-out SNCoio in-out ActLoopNT-in 2.822 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -106.87, 162.91 APE9-dihe-na 69.03, 158.68 APE8-dihe-in -76.06, 149.31 APE8-rot-in 284.97 APE67-dihe-in -59.95, -35.01 -52.77, -51.14 APE12-dist-in 13.793 APE11-dist-in 11.825 APE10-dist-out 8.193 APE9-dist-in 3.39 None PTR321 PTR321 XRAY 2.68 0.237 0.268 C 368 263 83 0 0 0 [[159, 479]] 1.0 5a4e CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4LB 133 480 763.0 ZC3:1481 Type1 Inactive DFGin 7.225 15.318 BLAminus -122.33, 174.38 63.37, 78.82 -100.66, 29.63 272.85, 85.35 -76.48, -46.67 in-in in 8.833 Saltbr-in 2.811 HRD-in -57.78, -46.91 78.18, -18.11 in-in-out SNCiio in-out ActLoopNT-in 3.43 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -127.68, 167.12 APE9-dihe-na 66.14, 152.91 APE8-dihe-in -68.52, 139.01 APE8-rot-in 283.99 APE67-dihe-in -47.52, -39.04 -51.76, -60.03 APE12-dist-in 13.532 APE11-dist-in 11.715 APE10-dist-out 8.072 APE9-dist-in 3.289 None PTR321 PTR321 XRAY 2.73 0.224 0.267 B 368 340 8 0 0 0 [[159, 479]] 1.0 5a4l CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4LC 135 479 763.0 ZC3:1480 Type1 Inactive DFGin 7.006 14.913 BLAminus -127.3, 155.33 73.19, 93.96 -111.33, 27.03 285.01, 85.59 -87.36, -7.31 in-in in 8.652 Saltbr-in 2.868 HRD-in -55.97, -40.82 79.57, -27.3 in-out-out SNCioo out-out ActLoopNT-out 3.704 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -124.41, 154.1 APE9-dihe-na 82.43, 157.05 APE8-dihe-in -75.01, 149.63 APE8-rot-in 309.36 APE67-dihe-in -58.73, -24.55 -56.34, -55.91 APE12-dist-in 13.808 APE11-dist-in 12.046 APE10-dist-out 8.197 APE9-dist-in 3.158 None PTR321 PTR321 XRAY 2.73 0.224 0.267 C 368 333 12 0 0 0 [[159, 479]] 1.0 5a4l CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4QA 134 480 763.0 Y3L:1482 Type1 Inactive DFGin 7.38 14.947 BLAminus -121.96, 169.12 70.4, 82.32 -101.36, 21.61 281.14, 85.06 -74.47, -27.67 in-in in 8.557 Saltbr-in 2.795 HRD-in -68.17, -45.62 80.68, 0.25 in-in-out SNCiio in-out ActLoopNT-in 3.014 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -134.46, 166.81 APE9-dihe-na 68.32, 157.62 APE8-dihe-in -82.19, 145.27 APE8-rot-in 292.08 APE67-dihe-in -61.8, -22.63 -55.55, -46.76 APE12-dist-in 13.736 APE11-dist-in 11.739 APE10-dist-out 8.013 APE9-dist-in 3.183 None PTR321 PTR321 XRAY 2.37 0.208 0.243 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a4q CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4QC 135 479 763.0 Y3L:1481 Type1 Inactive DFGin 7.364 15.042 BLAminus -123.78, 162.78 68.52, 86.63 -104.38, 24.62 284.41, 77.47 -79.32, -18.49 in-in in 8.564 Saltbr-in 2.739 HRD-in -62.28, -44.19 78.26, -0.42 in-in-out SNCiio in-out ActLoopNT-in 3.42 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -129.11, 155.72 APE9-dihe-na 82.33, 164.45 APE8-dihe-in -86.88, 143.97 APE8-rot-out 35.24 APE67-dihe-in -42.95, -31.53 -51.33, -61.96 APE12-dist-in 13.912 APE11-dist-in 11.966 APE10-dist-out 8.185 APE9-dist-in 3.243 None PTR321 PTR321 XRAY 2.37 0.208 0.243 C 368 333 12 0 0 0 [[159, 479]] 1.0 5a4q CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A4TC 135 479 763.0 AJG:1481 Type1 Inactive DFGin 7.147 15.179 BLAminus -129.41, 163.24 71.43, 82.89 -101.13, 32.11 287.17, 80.63 -81.63, -18.22 in-in in 8.495 Saltbr-in 2.998 HRD-in -61.24, -38.7 67.95, 6.62 in-in-out SNCiio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -116.62, 167.66 APE9-dihe-na 72.77, 139.58 APE8-dihe-in -64.52, 140.24 APE8-rot-out 38.46 APE67-dihe-in -54.94, -25.91 -49.67, -56.28 APE12-dist-in 13.98 APE11-dist-in 12.084 APE10-dist-out 8.048 APE9-dist-in 3.265 None PTR321 PTR321 XRAY 2.15 0.205 0.234 C 368 333 12 0 0 0 [[159, 479]] 1.0 5a4t CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
5A54C 135 479 763.0 5PW:1481 Type1 Inactive DFGin 7.357 15.035 BLAminus -136.48, 159.35 67.91, 80.5 -97.98, 19.65 286.78, 80.5 -74.6, -18.1 in-in in 8.603 Saltbr-in 3.392 HRD-in -58.19, -39.79 67.18, 10.59 in-in-out SNCiio in-out ActLoopNT-in 3.295 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -123.3, 160.72 APE9-dihe-na 73.36, 165.79 APE8-dihe-in -83.62, 148.27 APE8-rot-in 290.99 APE67-dihe-in -61.27, -24.7 -54.62, -49.48 APE12-dist-out 14.125 APE11-dist-in 12.294 APE10-dist-out 8.351 APE9-dist-in 3.067 None PTR321 PTR321 XRAY 2.63 0.224 0.255 C 368 333 12 0 0 0 [[159, 479]] 1.0 5a54 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIFB 133 480 763.0 B5T:501 Type1 Inactive DFGin 7.437 15.011 BLAminus -117.53, 169.82 65.45, 81.5 -101.1, 26.98 294.5, 81.24 -78.02, -31.68 in-in in 8.976 Saltbr-in 2.829 HRD-in -63.16, -42.31 73.8, 14.91 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -135.66, 162.2 APE9-dihe-na 65.08, 155.43 APE8-dihe-in -69.9, 152.14 APE8-rot-in 294.46 APE67-dihe-in -60.84, -36.77 -65.76, -40.73 APE12-dist-out 14.096 APE11-dist-in 11.816 APE10-dist-out 8.23 APE9-dist-in 3.428 None PTR321 PTR321 XRAY 2.22 0.22 0.25 B 368 338 10 0 0 0 [[159, 479]] 1.0 6eif CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIFC 135 479 763.0 B5T:501 Type1 Inactive DFGin 7.626 14.968 BLAminus -125.16, 167.64 65.65, 86.42 -102.01, 28.2 285.76, 74.26 -70.95, -35.41 in-in in 8.71 Saltbr-in 3.053 HRD-in -64.14, -45.72 70.72, 21.75 in-in-out SNCiio in-out ActLoopNT-in 2.79 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -144.86, 166.67 APE9-dihe-na 68.87, 169.54 APE8-dihe-in -80.46, 148.42 APE8-rot-in 289.45 APE67-dihe-in -66.62, -23.66 -60.62, -43.05 APE12-dist-out 14.237 APE11-dist-in 12.046 APE10-dist-out 8.222 APE9-dist-in 3.494 None PTR321 PTR321 XRAY 2.22 0.22 0.25 C 368 317 28 0 0 0 [[159, 479]] 1.0 6eif CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIFD 134 479 763.0 B5T:501 Type1 Inactive DFGin 7.545 15.131 BLAminus -129.8, 155.34 72.75, 87.67 -101.7, 34.46 287.1, 75.24 -73.21, -33.11 in-in in 8.874 Saltbr-in 2.757 HRD-in -60.8, -47.28 75.52, 7.01 in-in-out SNCiio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -135.58, 162.36 APE9-dihe-na 71.89, 152.04 APE8-dihe-in -66.91, 143.91 APE8-rot-out 183.99 APE67-dihe-in -59.93, -30.1 -58.92, -45.25 APE12-dist-out 14.091 APE11-dist-in 11.962 APE10-dist-out 8.149 APE9-dist-in 3.292 None PTR321 PTR321 XRAY 2.22 0.22 0.25 D 368 331 15 0 0 0 [[159, 479]] 1.0 6eif CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIJA 134 480 763.0 B5Z:501 Type1 Inactive DFGin 7.364 15.562 BLAminus -121.9, 173.42 62.65, 84.26 -101.23, 24.54 287.56, 69.73 -71.05, -32.94 in-out in 9.316 Saltbr-out 4.407 HRD-in -64.87, -43.16 72.94, 6.35 out-in-in SNCoii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.18, 163.75 APE9-dihe-na 69.36, 155.02 APE8-dihe-in -79.85, 135.64 APE8-rot-in 297.55 APE67-dihe-in -62.23, -27.92 -43.08, -47.75 APE12-dist-in 13.698 APE11-dist-in 11.612 APE10-dist-in 7.695 APE9-dist-in 3.216 None PTR321 PTR321 XRAY 2.42 0.215 0.242 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eij CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EILB 133 480 763.0 B6B:501 Type1 Inactive DFGin 7.341 14.861 BLAminus -128.37, 170.63 59.71, 81.26 -96.98, 27.13 287.97, 84.89 -67.89, -37.04 in-in in 8.814 Saltbr-in 2.913 HRD-in -65.15, -42.63 79.56, -12.9 in-in-out SNCiio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -124.14, 168.7 APE9-dihe-na 64.39, 148.37 APE8-dihe-in -69.18, 141.68 APE8-rot-in 298.05 APE67-dihe-in -55.34, -29.83 -58.23, -45.83 APE12-dist-in 13.832 APE11-dist-in 11.929 APE10-dist-out 8.154 APE9-dist-in 3.28 None PTR321 PTR321 XRAY 2.465 0.213 0.254 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eil CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EILD 134 479 763.0 B6B:501 Type1 Inactive DFGin 7.448 15.158 BLAminus -126.14, 168.46 63.24, 83.44 -99.13, 27.73 285.72, 76.69 -71.9, -27.65 in-in in 8.93 Saltbr-in 3.07 HRD-in -62.89, -42.01 72.08, 9.2 in-in-out SNCiio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -133.3, 168.91 APE9-dihe-na 66.72, 148.4 APE8-dihe-in -67.25, 141.01 APE8-rot-in 291.85 APE67-dihe-in -57.62, -29.33 -53.66, -47.87 APE12-dist-in 13.925 APE11-dist-in 11.798 APE10-dist-out 8.029 APE9-dist-in 3.279 None PTR321 PTR321 XRAY 2.465 0.213 0.254 D 368 333 13 0 0 0 [[159, 479]] 1.0 6eil CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIPA 134 480 763.0 B7B:501 Type1 Inactive DFGin 7.259 15.24 BLAminus -125.43, 172.01 62.72, 86.19 -100.26, 27.0 284.48, 74.29 -66.18, -40.51 in-out in 8.947 Saltbr-out 3.641 HRD-in -62.34, -44.05 75.6, 8.2 out-in-in SNCoii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.2, 165.59 APE9-dihe-na 64.6, 153.96 APE8-dihe-in -70.09, 140.96 APE8-rot-in 288.47 APE67-dihe-in -58.27, -33.16 -55.85, -46.32 APE12-dist-in 13.589 APE11-dist-in 11.661 APE10-dist-in 7.786 APE9-dist-in 3.253 None PTR321 PTR321 XRAY 2.56 0.243 0.266 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eip CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIPC 135 479 763.0 B7B:501 Type1 Inactive DFGin 7.364 15.276 BLAminus -125.37, 158.18 59.75, 86.95 -98.2, 25.76 287.16, 77.19 -71.86, -22.77 in-in in 8.799 Saltbr-in 3.16 HRD-in -69.43, -41.36 66.86, 11.92 in-in-out SNCiio in-out ActLoopNT-in 3.055 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -123.33, 159.25 APE9-dihe-na 71.82, 144.57 APE8-dihe-in -70.74, 143.31 APE8-rot-out 53.41 APE67-dihe-in -64.2, -26.78 -50.51, -45.83 APE12-dist-out 14.057 APE11-dist-in 11.942 APE10-dist-out 8.124 APE9-dist-in 3.321 None PTR321 PTR321 XRAY 2.56 0.243 0.266 C 368 339 6 0 0 0 [[159, 479]] 1.0 6eip CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIQA 134 480 763.0 B6Z:501 Type1 Inactive DFGin 7.844 15.002 BLAminus -118.74, 166.17 66.15, 80.44 -94.35, 21.46 285.58, 78.61 -71.38, -21.76 in-in in 8.611 Saltbr-in 2.926 HRD-in -64.07, -39.42 69.31, 1.03 in-in-out SNCiio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -140.51, 163.19 APE9-dihe-na 69.7, 156.6 APE8-dihe-in -69.88, 140.03 APE8-rot-in 262.24 APE67-dihe-in -50.14, -33.52 -54.08, -50.81 APE12-dist-in 13.87 APE11-dist-in 12.058 APE10-dist-out 8.058 APE9-dist-in 3.177 None PTR321 PTR321 XRAY 2.3 0.22 0.252 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eiq CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIQB 133 480 763.0 B6Z:501 Type1 Inactive DFGin 7.297 14.849 BLAminus -120.11, 166.43 71.57, 79.73 -95.19, 22.26 288.5, 77.93 -74.27, -18.06 in-in in 8.849 Saltbr-in 3.152 HRD-in -55.6, -50.6 83.2, -26.1 in-in-out SNCiio in-out ActLoopNT-in 2.76 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -126.72, 167.31 APE9-dihe-na 70.71, 154.35 APE8-dihe-in -72.28, 149.56 APE8-rot-in 304.02 APE67-dihe-in -63.36, -28.5 -63.02, -48.04 APE12-dist-out 14.336 APE11-dist-in 12.172 APE10-dist-out 8.104 APE9-dist-in 3.421 None PTR321 PTR321 XRAY 2.3 0.22 0.252 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eiq CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIQC 135 479 763.0 B6Z:501 Type1 Inactive DFGin 7.468 15.222 BLAminus -135.44, 157.29 69.01, 84.56 -97.19, 20.1 284.91, 77.49 -65.57, -27.64 in-in in 8.968 Saltbr-in 3.256 HRD-in -67.8, -34.77 66.66, 7.84 in-in-out SNCiio in-out ActLoopNT-in 2.69 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -132.75, 173.41 APE9-dihe-na 67.43, 156.08 APE8-dihe-in -71.33, 140.62 APE8-rot-in 274.81 APE67-dihe-in -64.01, -26.61 -57.83, -37.82 APE12-dist-out 14.005 APE11-dist-in 12.18 APE10-dist-out 8.189 APE9-dist-in 3.321 None PTR321 PTR321 XRAY 2.3 0.22 0.252 C 368 333 12 0 0 0 [[159, 479]] 1.0 6eiq CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIRA 134 480 763.0 B6H:501 Type1 Inactive DFGin 7.393 14.795 BLAminus -125.18, 166.81 63.57, 86.84 -99.28, 31.63 287.87, 74.48 -70.6, -35.95 in-in in 8.782 Saltbr-in 2.895 HRD-in -63.53, -49.11 75.82, 12.8 in-in-out SNCiio in-out ActLoopNT-in 3.052 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -140.45, 163.14 APE9-dihe-na 68.93, 157.09 APE8-dihe-in -74.57, 134.52 APE8-rot-in 295.13 APE67-dihe-in -54.09, -35.75 -49.98, -47.46 APE12-dist-in 13.834 APE11-dist-in 11.859 APE10-dist-out 8.03 APE9-dist-in 3.209 None PTR321 PTR321 XRAY 2.4 0.235 0.258 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eir CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIRB 133 480 763.0 B6H:501 Type1 Inactive DFGin 7.276 14.735 BLAminus -119.78, 174.81 68.91, 77.35 -98.17, 20.3 285.13, 87.39 -69.57, -27.99 in-in in 8.712 Saltbr-in 2.955 HRD-in -65.48, -40.64 68.84, 5.47 in-in-out SNCiio in-out ActLoopNT-in 2.731 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -144.55, 153.93 APE9-dihe-na 72.69, 153.36 APE8-dihe-in -69.83, 136.66 APE8-rot-in 293.84 APE67-dihe-in -59.39, -29.71 -51.99, -43.85 APE12-dist-out 14.548 APE11-dist-in 11.935 APE10-dist-out 8.485 APE9-dist-in 3.178 None PTR321 PTR321 XRAY 2.4 0.235 0.258 B 368 335 13 0 0 0 [[159, 479]] 1.0 6eir CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIRC 135 479 763.0 B6H:501 Type1 Inactive DFGin 7.412 15.039 BLAminus -130.82, 163.5 66.19, 85.94 -102.57, 28.49 281.77, 74.34 -75.43, -37.22 in-in in 8.512 Saltbr-in 2.752 HRD-in -65.03, -38.44 68.49, 5.65 in-in-out SNCiio in-out ActLoopNT-in 3.18 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -126.14, 166.06 APE9-dihe-na 64.03, 157.33 APE8-dihe-in -71.3, 146.96 APE8-rot-in 289.92 APE67-dihe-in -58.68, -32.01 -54.63, -47.82 APE12-dist-in 13.847 APE11-dist-in 11.909 APE10-dist-out 8.196 APE9-dist-in 3.124 None PTR321 PTR321 XRAY 2.4 0.235 0.258 C 368 333 12 0 0 0 [[159, 479]] 1.0 6eir CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIRD 134 479 763.0 B6H:501 Type1 Inactive DFGin 7.412 15.089 BLAminus -128.73, 160.15 68.25, 89.2 -103.65, 29.38 289.19, 75.86 -72.84, -26.68 in-in in 8.657 Saltbr-in 2.915 HRD-in -59.93, -46.06 73.72, 10.04 in-in-out SNCiio in-out ActLoopNT-in 2.872 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -138.86, 161.67 APE9-dihe-na 67.2, 154.51 APE8-dihe-in -70.63, 143.22 APE8-rot-in 290.43 APE67-dihe-in -57.31, -33.06 -57.15, -43.79 APE12-dist-out 14.027 APE11-dist-in 11.781 APE10-dist-in 7.978 APE9-dist-in 3.306 None PTR321 PTR321 XRAY 2.4 0.235 0.258 D 368 333 13 0 0 0 [[159, 479]] 1.0 6eir CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EISA 134 480 763.0 B6N:501 Type1 Inactive DFGin 7.388 15.073 BLAminus -121.06, 176.79 59.09, 85.05 -102.98, 23.5 282.6, 78.49 -72.76, -28.73 in-in in 8.522 Saltbr-in 2.684 HRD-in -60.79, -45.9 71.73, 8.72 in-in-out SNCiio in-out ActLoopNT-in 2.965 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -123.11, 168.92 APE9-dihe-na 67.38, 154.43 APE8-dihe-in -70.15, 143.5 APE8-rot-in 292.25 APE67-dihe-in -58.07, -26.24 -55.8, -46.96 APE12-dist-in 13.889 APE11-dist-in 11.917 APE10-dist-out 8.032 APE9-dist-in 3.263 None PTR321 PTR321 XRAY 2.36 0.223 0.262 A 368 345 2 0 0 0 [[159, 479]] 1.0 6eis CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EISC 135 479 763.0 B6N:501 Type1 Inactive DFGin 7.252 15.079 BLAminus -126.53, 168.59 63.16, 91.31 -107.92, 22.87 278.58, 80.44 -66.2, -35.95 in-in in 8.493 Saltbr-in 2.624 HRD-in -60.79, -42.31 68.89, 12.84 in-in-out SNCiio in-out ActLoopNT-in 2.758 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -121.65, 170.02 APE9-dihe-na 65.71, 162.09 APE8-dihe-in -78.55, 143.24 APE8-rot-in 293.4 APE67-dihe-in -58.46, -25.81 -54.9, -49.25 APE12-dist-in 13.875 APE11-dist-in 11.986 APE10-dist-out 8.187 APE9-dist-in 3.364 None PTR321 PTR321 XRAY 2.36 0.223 0.262 C 368 341 4 0 0 0 [[159, 479]] 1.0 6eis CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIVA 134 480 763.0 B6Q:501 Type1 Inactive DFGin 7.555 15.152 BLAminus -120.84, 171.67 57.39, 86.98 -102.78, 35.14 274.84, 85.24 -78.55, -29.99 in-in in 8.863 Saltbr-in 2.667 HRD-in -64.41, -32.42 61.66, 3.26 in-in-out SNCiio in-out ActLoopNT-in 2.583 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -115.94, 171.35 APE9-dihe-na 64.29, 157.62 APE8-dihe-in -72.84, 149.54 APE8-rot-in 294.84 APE67-dihe-in -70.56, -22.33 -58.23, -37.84 APE12-dist-in 13.979 APE11-dist-in 11.914 APE10-dist-out 8.132 APE9-dist-in 3.157 None PTR321 PTR321 XRAY 2.68 0.2 0.235 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eiv CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIVB 133 480 763.0 B6Q:501 Type1 Inactive DFGin 7.838 15.054 BLAminus -117.46, 173.9 54.13, 86.38 -99.45, 36.06 278.29, 87.94 -79.83, -33.89 in-in in 9.001 Saltbr-in 2.687 HRD-in -72.2, -37.83 60.09, 15.76 in-in-out SNCiio in-out ActLoopNT-in 3.031 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -115.67, 152.23 APE9-dihe-na 68.73, 155.27 APE8-dihe-in -64.12, 146.96 APE8-rot-in 304.3 APE67-dihe-in -70.42, -38.71 -50.76, -42.3 APE12-dist-out 14.313 APE11-dist-in 11.293 APE10-dist-out 8.714 APE9-dist-in 3.185 None PTR321 PTR321 XRAY 2.68 0.2 0.235 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eiv CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIVC 135 479 763.0 B6Q:501 Type1 Inactive DFGin 7.974 15.09 BLAminus -130.5, 162.34 68.37, 85.75 -108.43, 38.06 286.93, 86.81 -88.65, -21.51 in-in in 8.82 Saltbr-in 3.056 HRD-in -63.41, -36.37 61.31, 16.95 in-in-out SNCiio in-out ActLoopNT-in 3.132 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -105.82, 169.53 APE9-dihe-na 68.49, 151.95 APE8-dihe-in -66.67, 153.42 APE8-rot-out 50.58 APE67-dihe-in -66.4, -29.21 -58.54, -50.01 APE12-dist-out 14.024 APE11-dist-in 12.006 APE10-dist-out 8.071 APE9-dist-in 3.196 None PTR321 PTR321 XRAY 2.68 0.2 0.235 C 368 333 12 0 0 0 [[159, 479]] 1.0 6eiv CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIVD 134 479 763.0 B6Q:501 Type1 Inactive DFGin 7.858 14.788 BLAminus -123.28, 170.55 60.69, 87.47 -104.63, 40.75 289.41, 79.15 -84.06, -24.98 in-in in 8.939 Saltbr-in 3.077 HRD-in -80.96, -33.53 58.1, 20.23 in-in-out SNCiio in-out ActLoopNT-in 2.757 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -123.8, 169.26 APE9-dihe-na 65.27, 152.41 APE8-dihe-in -65.12, 144.68 APE8-rot-in 294.25 APE67-dihe-in -62.96, -33.45 -60.21, -40.79 APE12-dist-in 13.884 APE11-dist-in 11.72 APE10-dist-out 8.139 APE9-dist-in 3.184 None PTR321 PTR321 XRAY 2.68 0.2 0.235 D 368 333 13 0 0 0 [[159, 479]] 1.0 6eiv CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EJ4A 134 480 763.0 B7W:501 Type1 Inactive DFGin 7.338 14.948 BLAminus -132.19, 174.27 73.69, 75.25 -98.32, 20.37 284.23, 94.63 -75.42, -26.2 in-out in 8.869 Saltbr-out 4.041 HRD-in -58.96, -48.23 70.58, 13.6 out-in-out SNCoio in-out ActLoopNT-in 2.854 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -125.35, 166.33 APE9-dihe-na 69.65, 156.05 APE8-dihe-in -76.23, 139.99 APE8-rot-in 286.29 APE67-dihe-in -51.41, -21.41 -54.65, -48.5 APE12-dist-in 13.897 APE11-dist-in 11.661 APE10-dist-out 8.075 APE9-dist-in 3.187 None PTR321 PTR321 XRAY 2.88 0.222 0.27 A 368 344 3 0 0 0 [[159, 479]] 1.0 6ej4 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EJ4B 133 480 763.0 B7W:501 Type1 Inactive DFGin 7.107 14.76 BLAminus -124.17, 168.72 61.19, 91.64 -101.7, 11.62 289.3, 74.52 -55.92, -30.33 in-in in 8.759 Saltbr-in 2.833 HRD-in -65.73, -48.81 75.08, 26.7 in-in-out SNCiio in-out ActLoopNT-in 3.123 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -164.85, 149.17 APE9-dihe-na 68.91, 175.03 APE8-dihe-in -91.13, 144.68 APE8-rot-in 309.9 APE67-dihe-in -69.08, -39.33 -60.28, -35.15 APE12-dist-in 13.849 APE11-dist-in 11.526 APE10-dist-out 8.561 APE9-dist-in 3.913 None PTR321 PTR321 XRAY 2.88 0.222 0.27 B 368 338 10 0 0 0 [[159, 479]] 1.0 6ej4 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EJ4D 134 479 763.0 B7W:501 Type1 Inactive DFGin 7.849 14.665 BLAminus -127.93, 170.7 58.86, 87.06 -99.94, 27.16 296.94, 82.16 -71.66, -18.74 in-in in 8.69 Saltbr-in 2.71 HRD-in -59.65, -49.19 78.06, 3.89 in-in-out SNCiio in-out ActLoopNT-in 3.11 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.94, 163.29 APE9-dihe-na 74.33, 157.36 APE8-dihe-in -70.12, 155.62 APE8-rot-in 287.38 APE67-dihe-in -63.74, -29.78 -64.08, -46.32 APE12-dist-out 14.079 APE11-dist-in 11.966 APE10-dist-in 7.846 APE9-dist-in 3.243 None PTR321 PTR321 XRAY 2.88 0.222 0.27 D 368 331 15 0 0 0 [[159, 479]] 1.0 6ej4 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6YF8C 135 479 763.0 OPW:501 Type1 Inactive DFGin 7.06 14.935 BLAminus -124.46, 168.16 66.21, 86.05 -102.5, 27.56 285.91, 74.18 -71.62, -35.88 in-in in 8.498 Saltbr-in 2.557 HRD-in -64.26, -45.7 70.47, 20.75 in-in-out SNCiio in-out ActLoopNT-in 2.786 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.66, 167.21 APE9-dihe-na 69.24, 168.75 APE8-dihe-in -80.92, 148.18 APE8-rot-out 33.92 APE67-dihe-in -67.11, -24.9 -61.32, -43.38 APE12-dist-in 13.864 APE11-dist-in 11.499 APE10-dist-in 7.931 APE9-dist-in 3.227 None PTR321 PTR321 XRAY 3.198 0.251 0.283 C 368 333 12 0 0 0 [[159, 479]] 1.0 6yf8 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A4WB 134 481 763.0 QYH:501 Type1 Inactive DFGin 7.23 14.867 BLAminus -127.1, 165.63 77.7, 82.87 -96.17, 24.09 286.93, 79.55 -67.49, -32.84 in-in in 8.601 Saltbr-in 2.743 HRD-in -59.27, -48.69 70.77, 5.13 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -89.37, 163.93 APE9-dihe-na 72.54, 147.59 APE8-dihe-in -66.14, 133.19 APE8-rot-in 287.48 APE67-dihe-in -59.02, -29.56 -43.35, -51.99 APE12-dist-out 14.059 APE11-dist-in 12.004 APE10-dist-in 7.669 APE9-dist-in 3.117 None PTR321 PTR321 XRAY 2.7 0.165 0.205 B 382 341 7 0 0 0 [[159, 479]] 1.0 7a4w CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A55B 134 481 763.0 QZ2:501 Type1 Inactive DFGin 7.224 14.978 BLAminus -126.6, 167.5 73.14, 85.31 -100.14, 23.23 283.45, 82.86 -73.5, -24.04 in-in in 8.585 Saltbr-in 2.766 HRD-in -64.22, -46.85 72.39, 0.81 in-in-out SNCiio in-out ActLoopNT-in 2.962 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -88.13, 163.49 APE9-dihe-na 76.28, 147.59 APE8-dihe-in -62.05, 132.27 APE8-rot-in 298.44 APE67-dihe-in -60.88, -26.56 -41.66, -52.05 APE12-dist-out 14.126 APE11-dist-in 12.031 APE10-dist-in 7.602 APE9-dist-in 3.12 None PTR321 PTR321 XRAY 2.2 0.182 0.225 B 382 341 7 0 0 0 [[159, 479]] 1.0 7a55 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7A5BB 134 481 763.0 MFR:501 Type1 Inactive DFGin 7.363 14.842 BLAminus -128.7, 170.78 69.52, 88.76 -102.46, 24.68 283.18, 76.24 -69.64, -30.01 in-in in 8.335 Saltbr-in 2.7 HRD-in -58.52, -51.24 77.14, -0.56 in-in-out SNCiio in-out ActLoopNT-in 2.875 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -95.16, 165.26 APE9-dihe-na 71.85, 148.34 APE8-dihe-in -58.61, 134.95 APE8-rot-in 282.87 APE67-dihe-in -61.06, -26.55 -48.36, -47.01 APE12-dist-out 14.169 APE11-dist-in 12.052 APE10-dist-in 7.643 APE9-dist-in 2.983 None PTR321 PTR321 XRAY 2.6 0.155 0.192 B 382 341 7 0 0 0 [[159, 479]] 1.0 7a5b CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7O7KA 134 480 763.0 6ZV:803,LI:813 Type1,Allosteric Inactive DFGin 7.479 14.978 BLAminus -123.84, 172.32 71.95, 80.41 -97.61, 20.16 282.45, 81.55 -75.41, -18.82 in-in in 8.732 Saltbr-in 2.569 HRD-in -66.95, -44.76 74.49, -2.2 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.45, 171.41 APE9-dihe-na 76.66, 152.25 APE8-dihe-in -71.23, 142.04 APE8-rot-out 204.57 APE67-dihe-in -61.2, -25.53 -57.62, -46.09 APE12-dist-in 13.826 APE11-dist-in 12.396 APE10-dist-in 7.934 APE9-dist-in 3.209 None PTR321 PTR321 XRAY 1.82 0.179 0.205 A 361 345 2 0 0 0 [[159, 479]] 1.0 7o7k CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7O7KB 133 480 763.0 6ZV:504,LI:516 Type1,Allosteric Inactive DFGin 7.549 15.002 BLAminus -123.44, 173.38 69.65, 80.66 -97.78, 19.84 280.19, 88.12 -76.56, -16.84 in-in in 8.721 Saltbr-in 2.45 HRD-in -66.14, -44.61 73.06, -2.94 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -122.41, 168.28 APE9-dihe-na 77.46, 151.66 APE8-dihe-in -70.04, 138.71 APE8-rot-out 178.34 APE67-dihe-in -60.28, -25.12 -56.13, -47.11 APE12-dist-in 13.885 APE11-dist-in 12.364 APE10-dist-out 8.042 APE9-dist-in 3.108 None PTR321 PTR321 XRAY 1.82 0.179 0.205 B 361 345 3 0 0 0 [[159, 479]] 1.0 7o7k CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6EIJC 135 479 763.0 B5Z:501 Type1.5_Front Inactive DFGin 7.322 15.822 BLAminus -119.52, 178.29 74.66, 62.43 -90.76, 17.19 281.65, 84.11 -79.88, -15.93 in-in in 8.813 Saltbr-in 2.837 HRD-in -61.62, -44.31 72.29, 10.77 in-in-out SNCiio in-out ActLoopNT-in 3.127 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -131.72, 163.63 APE9-dihe-na 69.62, 151.36 APE8-dihe-in -71.38, 142.46 APE8-rot-in 288.31 APE67-dihe-in -55.52, -31.51 -56.59, -47.99 APE12-dist-in 13.973 APE11-dist-in 12.181 APE10-dist-out 8.281 APE9-dist-in 3.331 None PTR321 PTR321 XRAY 2.42 0.215 0.242 C 368 338 7 0 0 0 [[159, 479]] 1.0 6eij CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6UIPA 131 479 763.0 Q8J:501 Type1 Inactive DFGin 7.329 15.292 None -128.98, -33.2 -83.24, -86.92 68.74, 42.73 287.01, 105.17 -106.11, -43.86 in-in in 8.607 Saltbr-in 2.444 HRD-in -69.31, -45.72 68.49, 1.14 in-in-in SNCiii in-in ActLoopNT-in 3.034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.27, -51.33 APE9-dihe-na -84.83, 157.96 APE8-dihe-in -67.65, 136.35 APE8-rot-in 301.98 APE67-dihe-in -59.01, -29.0 -52.09, -48.51 APE12-dist-in 12.51 APE11-dist-in 10.849 APE10-dist-in 6.989 APE9-dist-in 3.23 None PTR321 PTR321 XRAY 3.7 0.272 0.29 A 361 345 4 0 0 0 [[159, 479]] 1.0 6uip CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
9FT2A 134 480 763.0 A1IE6:501 Type1 Inactive DFGin 7.574 15.895 None -123.41, -159.52 69.59, -109.27 67.33, -3.52 296.76, 96.58 -76.19, -5.59 in-in in 9.144 Saltbr-in 3.298 HRD-in -61.34, -38.17 66.08, 9.45 in-out-out SNCioo out-out ActLoopNT-out 4.114 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -106.57, 172.34 APE9-dihe-na 65.66, 156.83 APE8-dihe-in -69.73, 153.42 APE8-rot-out 183.57 APE67-dihe-in -64.1, -34.34 -62.54, -50.05 APE12-dist-in 11.165 APE11-dist-in 11.868 APE10-dist-in 7.923 APE9-dist-in 3.363 None PTR321 PTR321 XRAY 2.9 0.212 0.235 A 361 342 5 0 0 0 [[159, 479]] 1.0 9ft2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
9FT3A 134 480 763.0 A1IE7:501 Type1 Inactive DFGin 7.559 15.695 None -120.59, 174.62 87.74, -111.53 67.1, 10.68 308.34, 93.78 -70.59, -9.71 in-in in 8.841 Saltbr-in 2.944 HRD-in -61.2, -47.31 80.25, -0.32 in-out-out SNCioo out-out ActLoopNT-out 4.054 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.45, 165.76 APE9-dihe-na 76.29, 154.85 APE8-dihe-in -77.87, 145.0 APE8-rot-out 181.65 APE67-dihe-in -62.64, -27.73 -60.42, -45.99 APE12-dist-in 11.142 APE11-dist-in 12.008 APE10-dist-in 7.954 APE9-dist-in 3.156 None PTR321 PTR321 XRAY 2.7 0.196 0.23 A 361 342 5 0 0 0 [[159, 479]] 1.0 9ft3 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
9FT4A 134 480 763.0 A1IFJ:501 Type1 Inactive DFGin 7.628 15.767 None -120.71, -156.86 61.01, -103.63 67.38, -3.25 294.05, 97.87 -71.86, -4.64 in-in in 9.066 Saltbr-in 3.176 HRD-in -62.39, -36.73 64.58, 13.09 in-out-out SNCioo out-out ActLoopNT-out 4.028 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.4, 173.83 APE9-dihe-na 66.37, 159.49 APE8-dihe-in -70.35, 150.45 APE8-rot-out 182.43 APE67-dihe-in -65.5, -29.58 -61.56, -47.55 APE12-dist-in 11.232 APE11-dist-in 11.95 APE10-dist-in 7.918 APE9-dist-in 3.405 None PTR321 PTR321 XRAY 3.0 0.203 0.237 A 361 342 5 0 0 0 [[159, 479]] 1.0 9ft4 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
9FT6A 134 480 763.0 A1IE8:501 Type1 Inactive DFGin 7.585 15.816 None -126.75, 170.06 89.43, -106.36 68.66, 5.72 299.38, 96.13 -75.78, -8.95 in-in in 9.146 Saltbr-in 3.339 HRD-in -60.11, -40.88 70.11, 5.43 in-out-out SNCioo out-out ActLoopNT-out 3.939 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.56, 172.59 APE9-dihe-na 68.31, 156.56 APE8-dihe-in -68.23, 150.78 APE8-rot-out 177.43 APE67-dihe-in -63.38, -34.6 -61.07, -48.82 APE12-dist-in 11.185 APE11-dist-in 11.902 APE10-dist-in 7.877 APE9-dist-in 3.415 None PTR321 PTR321 XRAY 3.0 0.209 0.25 A 361 342 5 0 0 0 [[159, 479]] 1.0 9ft6 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
9FUFA 134 480 763.0 A1IFO:501 Type1 Inactive DFGin 7.669 15.743 None -124.23, -170.08 74.82, -105.33 66.79, 7.03 297.99, 97.28 -82.54, -3.73 in-in in 9.004 Saltbr-in 3.007 HRD-in -63.73, -39.36 69.07, 9.77 in-out-out SNCioo out-out ActLoopNT-out 4.112 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.16, 171.47 APE9-dihe-na 67.5, 156.88 APE8-dihe-in -71.53, 145.53 APE8-rot-out 186.89 APE67-dihe-in -63.53, -27.94 -60.87, -45.06 APE12-dist-in 11.194 APE11-dist-in 11.939 APE10-dist-in 7.905 APE9-dist-in 3.309 None PTR321 PTR321 XRAY 2.7 0.21 0.232 A 361 342 5 0 0 0 [[159, 479]] 1.0 9fuf CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
6S11B 136 480 763.0 KQE:501 Type1 None DFGin 7.321 14.74 BLAminus -122.66, 164.68 70.6, 90.6 -105.94, 27.83 286.74, 77.35 -71.95, -23.72 in-in in 8.564 Saltbr-in 3.103 HRD-in -69.08, -43.23 70.93, 5.16 in-in-none SNCiin in-none ActLoopNT-in 2.871 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -126.36, 176.02 APE9-dihe-na 69.06, 141.8 APE8-dihe-in -64.1, 141.34 APE8-rot-in 291.06 APE67-dihe-in -52.52, -31.33 -58.27, -46.65 APE12-dist-none 999.0 APE11-dist-in 11.465 APE10-dist-in 7.262 APE9-dist-in 3.159 None PTR321 PTR321 XRAY 2.445 0.173 0.21 B 361 330 15 0 0 3 [[159, 479]] 1.0 6s11 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
7Z5NH 135 480 763.0 3NG:501 Type1 None DFGin 6.679 14.847 BLAminus -128.66, -179.58 53.82, 77.25 -93.05, 20.83 280.85, 75.88 -63.97, -13.6 in-in in 9.075 Saltbr-in 3.001 HRD-in -63.15, -47.83 74.92, 6.9 in-in-none SNCiin in-none ActLoopNT-in 2.799 ActLoopCT-none nonTYR APEdihe_aaini APEdist_niii APE10-dihe-na -156.21, 166.85 APE9-dihe-na 64.29, 161.67 APE8-dihe-in -89.72, 140.84 APE8-rot-none 999.0 APE67-dihe-in -54.39, -32.97 -48.02, -56.25 APE12-dist-none 999.0 APE11-dist-in 10.614 APE10-dist-in 7.767 APE9-dist-in 3.208 None PTR321 PTR321 XRAY 2.77 0.207 0.252 H 370 307 39 0 0 4 [[159, 479]] 1.0 7z5n CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

CMGC_DYRK1A (Dual specificity tyrosine-phosphorylation-regulated kinase 1A)

Total number of chains: 235
Active chains: 145
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 226 96.2% AF-Q13627-K1A
DFGin None 6 2.6% 6UIPA
DFGin ABAminus 3 1.3% 9KRJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
DYR1A_HUMAN 7A4OA Q13627 136 481 763.0 ANP:501 ATPlike Active DFGin 7.404 15.034 BLAminus -121.6, 173.77 67.88, 73.96 -92.34, 22.26 284.87, 82.1 -70.26, -21.97 in-in in 8.684 Saltbr-in 2.793 HRD-in -65.03, -49.19 79.83, -0.94 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.61, 174.39 APE9-dihe-na 70.74, 151.67 APE8-dihe-in -72.34, 134.57 APE8-rot-in 295.77 APE67-dihe-in -65.19, -24.46 -43.45, -47.13 APE12-dist-in 10.098 APE11-dist-in 12.237 APE10-dist-in 7.723 APE9-dist-in 3.156 None PTR321 PTR321 XRAY 1.9 0.18 0.203 A 382 341 5 0 0 0 [[159, 479]] 1.0 7a4o Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN AF-Q13627-K1A Q13627 151 487 763.0 No_ligand No_ligand Active DFGin 7.099 14.822 BLAminus -126.07, 174.88 65.04, 63.05 -78.7, 14.51 284.78, 80.05 -60.76, -33.65 in-in in 8.656 Saltbr-in 2.714 HRD-in -68.27, -34.35 64.03, -15.38 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.02, 176.42 APE9-dihe-na 59.84, 143.69 APE8-dihe-in -63.5, 138.24 APE8-rot-in 290.81 APE67-dihe-in -65.87, -20.9 -54.43, -42.41 APE12-dist-in 12.758 APE11-dist-in 11.125 APE10-dist-in 7.099 APE9-dist-in 2.964 None None None AF2 -1.0 1.0 1.0 A 337 337 0 0 0 0 [[159, 479]] 1.0 AF-Q13627-K1 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 6.5e-91 310.6 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN AF-Q13627-K3A Q13627 151 487 763.0 No_ligand No_ligand Active DFGin 7.022 14.493 BLAminus -128.19, 173.68 64.75, 64.37 -75.81, 14.75 289.44, 85.21 -64.6, -21.99 in-in in 8.717 Saltbr-in 2.697 HRD-in -69.38, -38.91 69.17, -10.28 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.77, 176.19 APE9-dihe-na 61.66, 135.13 APE8-dihe-in -60.79, 140.78 APE8-rot-in 290.77 APE67-dihe-in -67.98, -20.6 -54.86, -44.85 APE12-dist-in 12.238 APE11-dist-in 10.675 APE10-dist-in 6.727 APE9-dist-in 3.139 None None None AF2 -1.0 1.0 1.0 A 337 337 0 0 0 0 [[159, 479]] 1.0 AF-Q13627-K3 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 6.5e-91 310.6 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6T6AD Q13627 135 481 763.0 No_ligand No_ligand Active DFGin 7.121 14.681 BLAminus -122.22, 178.29 61.07, 75.83 -93.67, 30.29 285.84, 74.34 -78.24, -5.35 in-in in 8.633 Saltbr-in 2.942 HRD-in -62.69, -43.95 76.48, -5.88 in-in-in SNCiii in-in ActLoopNT-in 2.847 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.02, 169.54 APE9-dihe-na 78.04, 146.93 APE8-dihe-in -67.8, 143.97 APE8-rot-in 270.75 APE67-dihe-in -62.33, -22.62 -60.21, -42.06 APE12-dist-in 12.775 APE11-dist-in 11.385 APE10-dist-in 7.064 APE9-dist-in 3.124 None PTR321 PTR321 XRAY 2.8 0.207 0.242 D 361 347 0 0 0 0 [[159, 479]] 1.0 6t6a Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6LN1A Q13627 135 480 763.0 EKU:60501 Type1 Active DFGin 7.54 14.912 BLAminus -115.21, 178.19 62.1, 76.45 -91.5, 24.99 284.48, 77.86 -70.41, -32.19 in-in in 8.828 Saltbr-in 2.784 HRD-in -69.61, -44.35 80.94, -0.24 in-in-in SNCiii in-in ActLoopNT-in 2.699 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -92.07, 176.48 APE9-dihe-na 66.77, 147.87 APE8-dihe-in -74.39, 150.81 APE8-rot-in 343.05 APE67-dihe-in -53.64, -21.6 -48.78, -54.67 APE12-dist-in 12.977 APE11-dist-in 11.304 APE10-dist-in 7.182 APE9-dist-in 3.189 None PTR321 PTR321 XRAY 2.699 0.217 0.277 A 347 341 5 0 0 0 [[159, 479]] 1.0 6ln1 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 4.7e-90 307.8 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6LN1B Q13627 140 479 763.0 EKU:60501 Type1 Active DFGin 7.089 14.398 BLAminus -101.75, -177.71 57.0, 58.3 -78.78, 41.72 301.2, 75.16 -82.62, -11.77 in-in in 8.771 Saltbr-in 2.6 HRD-in -46.38, -56.71 79.08, 7.56 in-in-in SNCiii in-in ActLoopNT-in 2.587 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 154.6 APE9-dihe-na 91.42, 164.72 APE8-dihe-in -88.63, 126.25 APE8-rot-in 268.81 APE67-dihe-in -84.49, -12.92 -41.57, -22.59 APE12-dist-in 13.502 APE11-dist-in 11.71 APE10-dist-in 7.576 APE9-dist-in 3.096 None PTR321 PTR321 XRAY 2.699 0.217 0.277 B 347 330 10 0 0 4 [[159, 479]] 1.0 6ln1 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 4.7e-90 307.8 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A4RA Q13627 148 479 763.0 QY8:60501 Type1 Active DFGin 7.3 14.891 BLAminus -123.91, 164.94 70.73, 83.02 -95.06, 19.69 291.95, 75.45 -62.6, -28.49 in-in in 8.514 Saltbr-in 2.704 HRD-in -61.82, -47.31 74.74, 3.26 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.99, 160.33 APE9-dihe-na 76.72, 147.14 APE8-dihe-in -69.21, 138.67 APE8-rot-in 293.85 APE67-dihe-in -64.87, -21.48 -52.75, -46.28 APE12-dist-in 12.299 APE11-dist-in 11.025 APE10-dist-in 7.23 APE9-dist-in 3.125 None PTR321 PTR321 XRAY 1.8 0.164 0.194 A 355 329 3 0 0 0 [[159, 479]] 1.0 7a4r Homo sapiens CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A4RB Q13627 148 479 763.0 QY8:60501 Type1 Active DFGin 7.208 14.962 BLAminus -119.24, 168.89 69.18, 79.44 -94.17, 25.13 286.75, 83.25 -70.93, -17.0 in-in in 8.768 Saltbr-in 2.72 HRD-in -64.89, -47.68 76.51, 0.83 in-in-in SNCiii in-in ActLoopNT-in 2.773 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.84, 166.7 APE9-dihe-na 79.54, 145.8 APE8-dihe-in -71.28, 139.09 APE8-rot-in 294.44 APE67-dihe-in -65.98, -21.95 -52.32, -45.54 APE12-dist-in 12.987 APE11-dist-in 11.288 APE10-dist-in 7.136 APE9-dist-in 3.129 None PTR321 PTR321 XRAY 1.8 0.164 0.194 B 355 326 6 0 0 0 [[159, 479]] 1.0 7a4r Homo sapiens CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A52B Q13627 148 479 763.0 QYB:60501 Type1 Active DFGin 7.429 14.685 BLAminus -117.36, 166.99 75.18, 78.44 -92.53, 26.04 294.13, 77.59 -62.87, -25.68 in-in in 8.756 Saltbr-in 2.849 HRD-in -65.57, -49.16 78.32, 2.35 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.88, 160.75 APE9-dihe-na 80.13, 142.69 APE8-dihe-in -66.42, 140.08 APE8-rot-in 292.67 APE67-dihe-in -65.51, -22.87 -52.45, -45.87 APE12-dist-in 12.973 APE11-dist-in 11.27 APE10-dist-in 7.231 APE9-dist-in 3.214 None PTR321 PTR321 XRAY 2.1 0.167 0.206 B 355 326 6 0 0 0 [[159, 479]] 1.0 7a52 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJMA Q13627 148 479 763.0 RKW:60501 Type1 Active DFGin 7.265 15.083 BLAminus -113.57, 168.88 72.84, 94.57 -110.24, 26.23 282.42, 78.09 -74.69, -26.47 in-in in 8.683 Saltbr-in 2.872 HRD-in -61.05, -48.34 70.03, 7.39 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.12, 155.94 APE9-dihe-na 76.79, 143.51 APE8-dihe-in -62.38, 139.96 APE8-rot-in 262.82 APE67-dihe-in -62.73, -28.02 -49.34, -49.5 APE12-dist-in 11.834 APE11-dist-in 10.579 APE10-dist-in 6.991 APE9-dist-in 3.106 None PTR321 PTR321 XRAY 2.4 0.164 0.21 A 355 329 3 0 0 0 [[159, 479]] 1.0 7ajm Homo sapiens CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJMB Q13627 148 479 763.0 RKW:60501 Type1 Active DFGin 6.994 14.671 BLAminus -112.64, 170.76 72.56, 91.79 -109.62, 28.16 283.39, 77.01 -72.83, -14.74 in-in in 8.845 Saltbr-in 2.814 HRD-in -64.07, -48.69 74.15, 3.15 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.54, 168.59 APE9-dihe-na 74.49, 143.62 APE8-dihe-in -65.42, 136.09 APE8-rot-in 307.57 APE67-dihe-in -62.29, -26.67 -49.12, -47.25 APE12-dist-in 12.723 APE11-dist-in 11.028 APE10-dist-in 6.764 APE9-dist-in 3.101 None PTR321 PTR321 XRAY 2.4 0.164 0.21 B 355 326 6 0 0 0 [[159, 479]] 1.0 7ajm Homo sapiens CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJSA Q13627 148 479 763.0 RKH:60501 Type1 Active DFGin 7.392 14.924 BLAminus -118.68, 165.34 71.79, 87.71 -102.61, 24.08 288.44, 78.59 -63.05, -35.5 in-in in 8.753 Saltbr-in 2.748 HRD-in -60.3, -47.5 67.56, 13.64 in-in-in SNCiii in-in ActLoopNT-in 2.832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.78, 153.94 APE9-dihe-na 77.54, 146.15 APE8-dihe-in -64.0, 138.0 APE8-rot-in 250.19 APE67-dihe-in -60.02, -31.0 -48.17, -52.76 APE12-dist-in 11.961 APE11-dist-in 10.616 APE10-dist-in 6.978 APE9-dist-in 3.153 None PTR321 PTR321 XRAY 2.15 0.163 0.2 A 355 329 3 0 0 0 [[159, 479]] 1.0 7ajs Homo sapiens CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJSB Q13627 148 479 763.0 RKH:60501 Type1 Active DFGin 7.162 14.64 BLAminus -115.69, 165.45 71.0, 84.62 -94.55, 26.84 288.65, 78.98 -76.35, -12.23 in-in in 8.769 Saltbr-in 2.943 HRD-in -67.11, -52.31 82.14, -1.84 in-in-in SNCiii in-in ActLoopNT-in 2.832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.36, 162.48 APE9-dihe-na 80.28, 144.7 APE8-dihe-in -73.09, 139.12 APE8-rot-in 302.28 APE67-dihe-in -65.82, -22.22 -51.22, -44.57 APE12-dist-in 12.902 APE11-dist-in 11.077 APE10-dist-in 6.906 APE9-dist-in 3.004 None PTR321 PTR321 XRAY 2.15 0.163 0.2 B 355 326 6 0 0 0 [[159, 479]] 1.0 7ajs Homo sapiens CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A4SA Q13627 149 481 763.0 QYE:501 Type1 Active DFGin 7.532 15.086 BLAminus -138.93, -174.53 57.29, 81.7 -100.85, 35.37 281.58, 79.44 -74.97, -23.82 in-in in 9.32 Saltbr-in 2.944 HRD-in -72.17, -47.36 73.35, 1.71 in-in-in SNCiii in-in ActLoopNT-in 3.05 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.71, 169.75 APE9-dihe-na 81.31, 157.64 APE8-dihe-in -82.41, 132.6 APE8-rot-in 288.96 APE67-dihe-in -59.27, -30.96 -45.34, -50.09 APE12-dist-in 13.06 APE11-dist-in 11.627 APE10-dist-in 7.172 APE9-dist-in 3.27 None PTR321 PTR321 XRAY 3.1 0.187 0.243 A 359 331 2 0 0 0 [[159, 479]] 1.0 7a4s Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A4ZA Q13627 148 481 763.0 6SD:60501 Type1 Active DFGin 7.3 14.456 BLAminus -123.85, 174.34 70.88, 81.03 -96.04, 32.37 287.17, 75.22 -72.9, -22.44 in-in in 8.592 Saltbr-in 2.704 HRD-in -62.51, -50.76 77.01, -4.38 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.05, 171.4 APE9-dihe-na 73.73, 155.23 APE8-dihe-in -74.89, 141.08 APE8-rot-in 296.68 APE67-dihe-in -55.98, -24.62 -56.22, -49.4 APE12-dist-in 12.89 APE11-dist-in 11.225 APE10-dist-in 6.887 APE9-dist-in 3.048 None PTR321 PTR321 XRAY 1.9 0.175 0.215 A 359 330 4 0 0 0 [[159, 479]] 1.0 7a4z Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A51A Q13627 148 481 763.0 QYK:60501 Type1 Active DFGin 7.291 14.599 BLAminus -122.4, 177.29 65.77, 77.26 -91.33, 30.79 285.93, 79.92 -72.92, -25.25 in-in in 8.818 Saltbr-in 2.674 HRD-in -57.59, -54.42 79.24, -4.5 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.35, 171.53 APE9-dihe-na 74.18, 152.76 APE8-dihe-in -73.09, 137.72 APE8-rot-in 302.32 APE67-dihe-in -57.09, -27.14 -52.91, -48.55 APE12-dist-in 12.924 APE11-dist-in 11.273 APE10-dist-in 6.852 APE9-dist-in 3.051 None PTR321 PTR321 XRAY 1.9 0.176 0.22 A 359 330 4 0 0 0 [[159, 479]] 1.0 7a51 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A53A Q13627 148 481 763.0 QYZ:60501 Type1 Active DFGin 6.956 14.876 BLAminus -124.21, 176.82 60.68, 75.14 -93.92, 34.06 288.73, 77.63 -73.67, -23.0 in-in in 8.892 Saltbr-in 2.46 HRD-in -59.2, -53.12 79.89, -5.25 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.62, 170.93 APE9-dihe-na 78.31, 140.71 APE8-dihe-in -58.15, 138.28 APE8-rot-in 298.09 APE67-dihe-in -53.16, -31.74 -53.07, -51.87 APE12-dist-in 12.976 APE11-dist-in 10.873 APE10-dist-in 6.772 APE9-dist-in 3.148 None PTR321 PTR321 XRAY 2.2 0.221 0.277 A 359 329 5 0 0 0 [[159, 479]] 1.0 7a53 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A53B Q13627 148 481 763.0 QYZ:60501 Type1 Active DFGin 6.959 14.912 BLAminus -126.16, 176.02 60.73, 71.28 -92.14, 32.04 282.75, 96.35 -75.78, -25.86 in-in in 8.559 Saltbr-in 2.618 HRD-in -58.54, -51.47 78.72, -0.57 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.26, 164.66 APE9-dihe-na 73.43, 144.67 APE8-dihe-in -58.03, 137.93 APE8-rot-in 308.72 APE67-dihe-in -53.34, -33.44 -52.19, -50.33 APE12-dist-in 13.334 APE11-dist-in 11.167 APE10-dist-in 7.421 APE9-dist-in 2.938 None PTR321 PTR321 XRAY 2.2 0.221 0.277 B 359 328 6 0 0 0 [[159, 479]] 1.0 7a53 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A5DA Q13627 148 481 763.0 QYW:60503 Type1 Active DFGin 7.291 14.499 BLAminus -125.92, 173.48 71.61, 80.32 -97.3, 32.34 286.41, 76.72 -76.78, -19.61 in-in in 8.581 Saltbr-in 2.928 HRD-in -61.07, -50.08 76.51, -7.31 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.46, 171.52 APE9-dihe-na 73.74, 152.43 APE8-dihe-in -73.09, 139.23 APE8-rot-in 301.1 APE67-dihe-in -59.42, -24.32 -53.95, -47.3 APE12-dist-in 12.903 APE11-dist-in 11.253 APE10-dist-in 6.819 APE9-dist-in 3.043 None PTR321 PTR321 XRAY 1.8 0.169 0.198 A 359 330 4 0 0 0 [[159, 479]] 1.0 7a5d Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A5LA Q13627 148 481 763.0 QZW:60501 Type1 Active DFGin 7.218 14.635 BLAminus -121.54, 170.14 72.24, 87.61 -101.02, 30.38 286.05, 77.12 -71.68, -20.82 in-in in 8.522 Saltbr-in 2.809 HRD-in -64.85, -49.91 77.97, -7.38 in-in-in SNCiii in-in ActLoopNT-in 2.76 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.06, 173.85 APE9-dihe-na 71.88, 150.72 APE8-dihe-in -74.11, 138.59 APE8-rot-in 300.11 APE67-dihe-in -57.42, -25.87 -52.04, -49.48 APE12-dist-in 12.969 APE11-dist-in 11.336 APE10-dist-in 6.922 APE9-dist-in 3.017 None PTR321 PTR321 XRAY 2.1 0.17 0.219 A 359 330 4 0 0 0 [[159, 479]] 1.0 7a5l Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A5NA Q13627 148 481 763.0 R05:60501 Type1 Active DFGin 7.403 14.447 BLAminus -130.77, 171.88 72.71, 82.27 -106.45, 26.81 288.21, 62.13 -65.93, -43.81 in-in in 8.598 Saltbr-in 3.065 HRD-in -57.21, -52.7 74.49, 12.94 in-in-in SNCiii in-in ActLoopNT-in 3.062 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.21, 148.03 APE9-dihe-na 71.58, 141.19 APE8-dihe-in -66.77, 132.98 APE8-rot-in 271.46 APE67-dihe-in -59.22, -30.19 -42.88, -51.66 APE12-dist-in 11.248 APE11-dist-in 9.343 APE10-dist-in 6.727 APE9-dist-in 3.128 None PTR321 PTR321 XRAY 2.3 0.222 0.285 A 359 331 3 0 0 0 [[159, 479]] 1.0 7a5n Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A5NB Q13627 148 481 763.0 R05:60501 Type1 Active DFGin 7.141 14.629 BLAminus -127.78, 175.57 50.44, 91.01 -100.1, 27.58 280.57, 76.94 -87.61, 4.92 in-in in 8.555 Saltbr-in 3.016 HRD-in -52.87, -55.56 83.95, -3.37 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.68, 165.98 APE9-dihe-na 74.29, 148.76 APE8-dihe-in -64.04, 140.88 APE8-rot-in 335.23 APE67-dihe-in -57.78, -36.24 -50.19, -48.03 APE12-dist-in 13.004 APE11-dist-in 10.844 APE10-dist-in 6.638 APE9-dist-in 3.12 None PTR321 PTR321 XRAY 2.3 0.222 0.285 B 359 325 9 0 0 0 [[159, 479]] 1.0 7a5n Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJ2A Q13627 148 481 763.0 RJ5:501 Type1 Active DFGin 7.24 14.559 BLAminus -122.01, 172.44 70.8, 81.8 -97.31, 27.59 285.79, 75.24 -65.4, -26.17 in-in in 8.494 Saltbr-in 2.647 HRD-in -59.33, -51.1 76.85, -6.27 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.89, 169.24 APE9-dihe-na 76.24, 151.09 APE8-dihe-in -74.37, 141.15 APE8-rot-in 296.76 APE67-dihe-in -60.14, -26.69 -54.23, -46.92 APE12-dist-in 12.982 APE11-dist-in 11.374 APE10-dist-in 6.836 APE9-dist-in 3.025 None PTR321 PTR321 XRAY 2.1 0.177 0.218 A 359 330 4 0 0 0 [[159, 479]] 1.0 7aj2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJ4A Q13627 149 481 763.0 RHZ:501 Type1 Active DFGin 7.311 14.601 BLAminus -123.99, 173.51 70.54, 81.2 -94.73, 29.42 286.45, 75.23 -67.9, -25.54 in-in in 8.635 Saltbr-in 2.816 HRD-in -57.38, -53.76 80.58, -8.62 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.55, 172.78 APE9-dihe-na 75.87, 151.36 APE8-dihe-in -72.21, 138.63 APE8-rot-in 297.12 APE67-dihe-in -55.82, -28.26 -51.87, -50.68 APE12-dist-in 12.866 APE11-dist-in 11.261 APE10-dist-in 6.705 APE9-dist-in 3.037 None PTR321 PTR321 XRAY 2.0 0.172 0.212 A 359 329 4 0 0 0 [[159, 479]] 1.0 7aj4 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJ5A Q13627 149 481 763.0 RHW:501 Type1 Active DFGin 7.347 14.591 BLAminus -124.58, 171.68 71.78, 84.04 -100.42, 29.77 286.07, 78.8 -68.78, -26.1 in-in in 8.591 Saltbr-in 2.731 HRD-in -66.86, -51.83 82.75, -10.17 in-in-in SNCiii in-in ActLoopNT-in 2.826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.64, 172.12 APE9-dihe-na 70.48, 150.71 APE8-dihe-in -69.64, 139.8 APE8-rot-in 304.28 APE67-dihe-in -56.6, -26.89 -56.07, -46.59 APE12-dist-in 12.766 APE11-dist-in 11.205 APE10-dist-in 6.736 APE9-dist-in 3.05 None PTR321 PTR321 XRAY 2.0 0.173 0.202 A 359 330 3 0 0 0 [[159, 479]] 1.0 7aj5 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJ7A Q13627 149 481 763.0 RHT:501 Type1 Active DFGin 7.213 14.444 BLAminus -137.43, 175.11 63.05, 82.92 -98.13, 25.37 284.49, 76.3 -61.96, -29.41 in-in in 8.512 Saltbr-in 2.773 HRD-in -62.96, -50.98 78.34, -8.02 in-in-in SNCiii in-in ActLoopNT-in 2.952 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.89, 173.67 APE9-dihe-na 76.79, 147.68 APE8-dihe-in -65.86, 142.81 APE8-rot-in 285.72 APE67-dihe-in -58.43, -30.42 -57.45, -46.57 APE12-dist-in 12.549 APE11-dist-in 11.153 APE10-dist-in 6.711 APE9-dist-in 2.857 None PTR321 PTR321 XRAY 2.9 0.187 0.244 A 359 329 4 0 0 0 [[159, 479]] 1.0 7aj7 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJ8A Q13627 148 481 763.0 RJ8:501 Type1 Active DFGin 7.295 14.549 BLAminus -122.29, 170.47 71.74, 84.57 -99.84, 28.97 281.02, 79.91 -71.8, -23.08 in-in in 8.537 Saltbr-in 2.697 HRD-in -60.09, -51.67 74.99, -7.51 in-in-in SNCiii in-in ActLoopNT-in 2.81 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.41, 173.91 APE9-dihe-na 73.53, 152.08 APE8-dihe-in -72.76, 139.89 APE8-rot-in 300.81 APE67-dihe-in -58.72, -27.07 -52.93, -47.73 APE12-dist-in 12.8 APE11-dist-in 11.225 APE10-dist-in 6.7 APE9-dist-in 2.973 None PTR321 PTR321 XRAY 2.0 0.175 0.21 A 359 330 4 0 0 0 [[159, 479]] 1.0 7aj8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJAA Q13627 148 481 763.0 RJ2:501 Type1 Active DFGin 7.291 14.665 BLAminus -122.57, -179.95 65.98, 77.73 -92.38, 29.12 284.23, 75.93 -66.67, -27.05 in-in in 8.531 Saltbr-in 3.04 HRD-in -57.61, -51.76 76.82, -10.69 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.46, 175.17 APE9-dihe-na 69.93, 152.41 APE8-dihe-in -73.84, 143.1 APE8-rot-in 301.04 APE67-dihe-in -58.66, -26.17 -57.24, -46.95 APE12-dist-in 12.858 APE11-dist-in 11.253 APE10-dist-in 6.811 APE9-dist-in 2.994 None PTR321 PTR321 XRAY 2.2 0.17 0.206 A 359 330 4 0 0 0 [[159, 479]] 1.0 7aja Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJWA Q13627 149 481 763.0 RKQ:501 Type1 Active DFGin 7.15 14.109 BLAminus -134.56, 173.1 66.48, 91.61 -108.25, 30.66 287.96, 79.17 -74.2, -20.6 in-in in 8.555 Saltbr-in 2.654 HRD-in -67.52, -49.1 73.04, -0.56 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.59, 173.44 APE9-dihe-na 72.74, 148.59 APE8-dihe-in -66.33, 137.19 APE8-rot-in 261.72 APE67-dihe-in -58.85, -29.4 -50.84, -53.2 APE12-dist-in 12.66 APE11-dist-in 10.887 APE10-dist-in 6.549 APE9-dist-in 2.84 None PTR321 PTR321 XRAY 2.8 0.182 0.237 A 359 330 3 0 0 0 [[159, 479]] 1.0 7ajw Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AKLA Q13627 148 481 763.0 RK5:501 Type1 Active DFGin 7.3 14.425 BLAminus -122.02, 174.03 72.11, 83.92 -100.72, 31.09 288.14, 76.27 -72.0, -23.45 in-in in 8.638 Saltbr-in 2.745 HRD-in -60.22, -54.09 78.11, -4.59 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.03, 174.13 APE9-dihe-na 72.3, 150.01 APE8-dihe-in -71.28, 141.43 APE8-rot-in 296.39 APE67-dihe-in -55.01, -28.18 -52.85, -51.29 APE12-dist-in 12.783 APE11-dist-in 11.183 APE10-dist-in 6.726 APE9-dist-in 3.081 None PTR321 PTR321 XRAY 2.0 0.169 0.21 A 359 330 4 0 0 0 [[159, 479]] 1.0 7akl Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6A1FA Q13627 134 483 763.0 9OF:807 Type1 Active DFGin 7.205 15.092 BLAminus -125.52, 173.04 69.56, 79.06 -100.37, 18.23 289.23, 81.85 -66.74, -28.25 in-in in 8.712 Saltbr-in 2.843 HRD-in -63.72, -44.37 75.39, -2.34 in-in-in SNCiii in-in ActLoopNT-in 2.826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.51, 164.33 APE9-dihe-na 78.19, 142.16 APE8-dihe-in -71.23, 146.24 APE8-rot-in 287.31 APE67-dihe-in -64.89, -24.24 -54.81, -45.1 APE12-dist-in 13.001 APE11-dist-in 10.937 APE10-dist-in 7.397 APE9-dist-in 3.189 None PTR321 PTR321 XRAY 1.5 0.178 0.195 A 360 346 4 0 0 0 [[159, 479]] 1.0 6a1f Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6A1GA Q13627 134 480 763.0 9OL:801 Type1 Active DFGin 7.443 15.234 BLAminus -131.63, 174.89 62.52, 74.46 -86.81, 24.41 283.22, 87.78 -81.01, -15.6 in-in in 8.67 Saltbr-in 2.915 HRD-in -61.79, -54.2 82.78, 1.79 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.6, 165.45 APE9-dihe-na 76.44, 148.51 APE8-dihe-in -74.95, 145.84 APE8-rot-in 297.26 APE67-dihe-in -65.55, -18.66 -55.25, -42.45 APE12-dist-in 13.856 APE11-dist-in 11.648 APE10-dist-in 7.423 APE9-dist-in 3.22 None PTR321 PTR321 XRAY 2.15 0.227 0.272 A 360 338 9 0 0 0 [[159, 479]] 1.0 6a1g Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6A1GB Q13627 135 480 763.0 9OL:801 Type1 Active DFGin 7.579 15.287 BLAminus -122.59, 172.34 65.77, 71.51 -90.8, 21.72 282.42, 87.2 -69.78, -18.18 in-in in 8.764 Saltbr-in 2.721 HRD-in -62.09, -51.04 83.6, -3.9 in-in-in SNCiii in-in ActLoopNT-in 2.747 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.01, 163.93 APE9-dihe-na 74.32, 145.62 APE8-dihe-in -65.74, 146.16 APE8-rot-in 294.53 APE67-dihe-in -67.18, -18.01 -56.08, -44.17 APE12-dist-in 13.833 APE11-dist-in 11.814 APE10-dist-in 7.752 APE9-dist-in 3.148 None PTR321 PTR321 XRAY 2.15 0.227 0.272 B 360 338 8 0 0 0 [[159, 479]] 1.0 6a1g Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8YEVA Q13627 135 480 763.0 CUE:501 Type1 Active DFGin 7.434 14.786 BLAminus -118.94, 172.54 64.6, 78.63 -91.29, 26.52 288.98, 71.88 -65.34, -22.12 in-in in 8.522 Saltbr-in 2.577 HRD-in -68.73, -47.85 77.13, 4.82 in-in-in SNCiii in-in ActLoopNT-in 2.782 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.05, 170.5 APE9-dihe-na 69.2, 142.92 APE8-dihe-in -70.94, 147.42 APE8-rot-in 313.88 APE67-dihe-in -60.8, -23.15 -60.0, -43.7 APE12-dist-in 12.556 APE11-dist-in 11.383 APE10-dist-in 7.294 APE9-dist-in 3.152 None PTR321 PTR321 XRAY 2.252 0.187 0.239 A 360 346 0 0 0 0 [[159, 479]] 1.0 8yev Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8YEVB Q13627 135 480 763.0 CUE:501 Type1 Active DFGin 7.16 14.723 BLAminus -120.23, 173.78 62.44, 74.7 -88.8, 24.95 292.77, 72.65 -67.21, -11.0 in-in in 8.498 Saltbr-in 2.873 HRD-in -63.02, -42.24 73.2, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.663 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.96, 167.57 APE9-dihe-na 75.54, 148.76 APE8-dihe-in -70.82, 139.27 APE8-rot-in 281.75 APE67-dihe-in -60.51, -21.18 -55.07, -44.69 APE12-dist-in 12.796 APE11-dist-in 11.433 APE10-dist-in 7.267 APE9-dist-in 3.135 None PTR321 PTR321 XRAY 2.252 0.187 0.239 B 360 341 5 0 0 0 [[159, 479]] 1.0 8yev Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4MQ1A Q13627 135 480 763.0 2C3:501 Type1 Active DFGin 7.28 14.944 BLAminus -107.08, 169.28 64.33, 86.56 -96.37, 23.11 286.39, 71.27 -52.4, -28.63 in-in in 8.847 Saltbr-in 2.938 HRD-in -69.08, -48.33 84.08, -3.18 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.98, 166.32 APE9-dihe-na 74.9, 147.34 APE8-dihe-in -69.7, 145.86 APE8-rot-in 305.52 APE67-dihe-in -59.42, -25.59 -55.64, -47.81 APE12-dist-in 13.636 APE11-dist-in 11.377 APE10-dist-in 7.303 APE9-dist-in 3.132 None PTR321 PTR321 XRAY 2.35 0.204 0.246 A 361 346 0 0 0 0 [[159, 479]] 1.0 4mq1 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4MQ1B Q13627 135 480 763.0 2C3:501 Type1 Active DFGin 7.167 14.962 BLAminus -118.05, 178.11 65.5, 78.17 -95.21, 21.1 286.61, 77.13 -53.53, -31.57 in-in in 8.832 Saltbr-in 2.711 HRD-in -66.94, -41.93 74.32, -0.92 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.36, 163.1 APE9-dihe-na 74.84, 141.93 APE8-dihe-in -61.52, 141.81 APE8-rot-in 294.42 APE67-dihe-in -64.73, -20.55 -55.53, -44.91 APE12-dist-in 13.85 APE11-dist-in 11.968 APE10-dist-in 7.434 APE9-dist-in 3.145 None PTR321 PTR321 XRAY 2.35 0.204 0.246 B 361 341 5 0 0 0 [[159, 479]] 1.0 4mq1 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4MQ1C Q13627 135 479 763.0 2C3:501 Type1 Active DFGin 7.123 14.743 BLAminus -115.5, 174.34 57.95, 89.02 -100.48, 19.79 291.2, 71.21 -59.19, -10.35 in-in in 8.677 Saltbr-in 2.838 HRD-in -64.04, -46.07 77.17, 1.7 in-in-in SNCiii in-in ActLoopNT-in 2.825 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.41, 171.13 APE9-dihe-na 68.46, 151.93 APE8-dihe-in -76.63, 143.11 APE8-rot-in 282.43 APE67-dihe-in -62.99, -29.42 -51.54, -49.58 APE12-dist-in 13.421 APE11-dist-in 12.36 APE10-dist-in 7.454 APE9-dist-in 3.19 None PTR321 PTR321 XRAY 2.35 0.204 0.246 C 361 329 16 0 0 0 [[159, 479]] 1.0 4mq1 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4MQ1D Q13627 135 479 763.0 2C3:501 Type1 Active DFGin 7.019 14.808 BLAminus -126.44, 171.84 66.4, 87.23 -103.93, 24.03 286.04, 72.97 -66.45, -19.49 in-in in 8.854 Saltbr-in 3.063 HRD-in -60.3, -51.7 83.34, -2.89 in-in-in SNCiii in-in ActLoopNT-in 2.623 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.6, 163.81 APE9-dihe-na 70.67, 153.02 APE8-dihe-in -82.69, 145.06 APE8-rot-in 286.24 APE67-dihe-in -63.44, -21.16 -53.8, -45.92 APE12-dist-in 13.969 APE11-dist-in 11.879 APE10-dist-in 7.612 APE9-dist-in 3.091 None PTR321 PTR321 XRAY 2.35 0.204 0.246 D 361 337 8 0 0 0 [[159, 479]] 1.0 4mq1 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4MQ2A Q13627 136 481 763.0 2C4:501 Type1 Active DFGin 6.868 14.409 BLAminus -121.27, 179.82 65.24, 80.7 -100.33, 34.12 292.19, 76.56 -77.48, -4.08 in-in in 8.662 Saltbr-in 2.601 HRD-in -69.08, -52.44 83.64, -11.94 in-in-in SNCiii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.51, 172.47 APE9-dihe-na 67.48, 158.72 APE8-dihe-in -76.65, 148.34 APE8-rot-in 274.49 APE67-dihe-in -48.43, -32.19 -58.16, -54.33 APE12-dist-in 12.976 APE11-dist-in 11.302 APE10-dist-in 7.083 APE9-dist-in 2.96 None PTR321 PTR321 XRAY 2.8 0.193 0.258 A 361 344 2 0 0 0 [[159, 479]] 1.0 4mq2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4MQ2B Q13627 135 480 763.0 2C4:501 Type1 Active DFGin 7.053 14.829 BLAminus -112.51, 178.58 64.85, 72.08 -90.53, 21.44 285.46, 79.73 -54.32, -51.42 in-in in 8.7 Saltbr-in 2.465 HRD-in -55.52, -42.79 72.77, 8.39 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.3, 169.51 APE9-dihe-na 72.97, 142.27 APE8-dihe-in -68.49, 133.29 APE8-rot-in 303.19 APE67-dihe-in -62.35, -17.83 -46.19, -44.59 APE12-dist-in 13.951 APE11-dist-in 11.826 APE10-dist-in 7.221 APE9-dist-in 3.228 None PTR321 PTR321 XRAY 2.8 0.193 0.258 B 361 339 7 0 0 0 [[159, 479]] 1.0 4mq2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4MQ2C Q13627 135 480 763.0 2C4:501 Type1 Active DFGin 7.135 14.542 BLAminus -124.8, 176.28 61.28, 87.41 -103.36, 27.2 293.3, 79.71 -80.85, 14.66 in-in in 8.563 Saltbr-in 2.857 HRD-in -66.22, -46.45 80.74, -5.39 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.81, 170.36 APE9-dihe-na 74.19, 145.98 APE8-dihe-in -63.45, 145.7 APE8-rot-in 275.14 APE67-dihe-in -56.78, -28.08 -53.65, -50.23 APE12-dist-in 13.336 APE11-dist-in 11.439 APE10-dist-in 7.154 APE9-dist-in 3.083 None PTR321 PTR321 XRAY 2.8 0.193 0.258 C 361 340 6 0 0 0 [[159, 479]] 1.0 4mq2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4YLJA Q13627 135 481 763.0 4E1:505 Type1 Active DFGin 7.171 14.69 BLAminus -120.74, 179.02 60.36, 78.67 -97.57, 26.9 291.22, 73.75 -64.98, -15.53 in-in in 8.716 Saltbr-in 2.986 HRD-in -64.06, -46.78 79.78, -3.33 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.96, 172.9 APE9-dihe-na 73.38, 148.79 APE8-dihe-in -71.08, 143.3 APE8-rot-in 281.86 APE67-dihe-in -60.03, -27.35 -56.02, -46.64 APE12-dist-in 12.415 APE11-dist-in 11.382 APE10-dist-in 7.129 APE9-dist-in 3.148 None PTR321 PTR321 XRAY 2.58 0.193 0.222 A 361 347 0 0 0 0 [[159, 479]] 1.0 4ylj Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4YLJB Q13627 134 481 763.0 4E1:508 Type1 Active DFGin 7.17 14.829 BLAminus -121.55, 178.75 61.01, 77.19 -96.15, 26.83 289.05, 74.2 -67.89, -14.86 in-in in 8.741 Saltbr-in 2.994 HRD-in -63.71, -44.48 77.69, -2.83 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.19, 171.89 APE9-dihe-na 74.49, 148.58 APE8-dihe-in -68.34, 142.12 APE8-rot-in 282.31 APE67-dihe-in -56.89, -29.19 -56.17, -46.65 APE12-dist-in 12.631 APE11-dist-in 11.965 APE10-dist-in 7.323 APE9-dist-in 3.115 None PTR321 PTR321 XRAY 2.58 0.193 0.222 B 361 348 0 0 0 0 [[159, 479]] 1.0 4ylj Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4YLJC Q13627 135 481 763.0 4E1:503 Type1 Active DFGin 7.205 14.729 BLAminus -122.29, 179.51 59.93, 77.71 -95.82, 25.73 289.89, 74.73 -67.2, -13.85 in-in in 8.697 Saltbr-in 2.963 HRD-in -63.45, -46.33 78.82, -3.67 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.91, 172.11 APE9-dihe-na 74.94, 150.31 APE8-dihe-in -71.52, 143.35 APE8-rot-in 282.23 APE67-dihe-in -59.75, -28.5 -57.04, -44.59 APE12-dist-in 12.408 APE11-dist-in 11.398 APE10-dist-in 7.171 APE9-dist-in 3.131 None PTR321 PTR321 XRAY 2.58 0.193 0.222 C 361 347 0 0 0 0 [[159, 479]] 1.0 4ylj Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4YLJD Q13627 134 481 763.0 4E1:505 Type1 Active DFGin 7.199 14.803 BLAminus -121.44, 179.35 58.86, 78.49 -97.14, 26.21 290.36, 74.03 -66.11, -15.53 in-in in 8.75 Saltbr-in 2.981 HRD-in -63.57, -46.82 79.76, -3.19 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.75, 172.88 APE9-dihe-na 73.07, 149.38 APE8-dihe-in -71.54, 142.69 APE8-rot-in 281.4 APE67-dihe-in -59.08, -29.21 -56.77, -45.97 APE12-dist-in 12.518 APE11-dist-in 11.514 APE10-dist-in 7.3 APE9-dist-in 3.134 None PTR321 PTR321 XRAY 2.58 0.193 0.222 D 361 348 0 0 0 0 [[159, 479]] 1.0 4ylj Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4YLKA Q13627 134 481 763.0 4E2:519 Type1 Active DFGin 7.158 15.056 BLAminus -121.3, 173.23 68.75, 82.1 -101.46, 18.43 287.84, 80.51 -66.33, -24.85 in-in in 8.808 Saltbr-in 2.835 HRD-in -60.82, -45.77 73.28, 1.75 in-in-in SNCiii in-in ActLoopNT-in 2.798 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.3, 165.02 APE9-dihe-na 76.33, 137.8 APE8-dihe-in -71.51, 143.14 APE8-rot-in 292.21 APE67-dihe-in -62.85, -23.79 -52.79, -45.95 APE12-dist-in 12.9 APE11-dist-in 10.859 APE10-dist-in 7.405 APE9-dist-in 3.227 None PTR321 PTR321 XRAY 1.4 0.156 0.177 A 361 342 6 0 0 0 [[159, 479]] 1.0 4ylk Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4YLLA Q13627 134 481 763.0 4E3:515 Type1 Active DFGin 7.124 15.005 BLAminus -121.37, 173.09 67.61, 81.84 -100.09, 19.61 289.57, 78.47 -68.0, -24.32 in-in in 8.778 Saltbr-in 2.819 HRD-in -61.7, -47.42 73.98, 3.3 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.49, 164.4 APE9-dihe-na 78.13, 136.62 APE8-dihe-in -68.39, 143.3 APE8-rot-in 291.54 APE67-dihe-in -64.28, -22.41 -51.37, -47.28 APE12-dist-in 12.865 APE11-dist-in 10.831 APE10-dist-in 7.376 APE9-dist-in 3.217 None PTR321 PTR321 XRAY 1.4 0.152 0.172 A 361 342 6 0 0 0 [[159, 479]] 1.0 4yll Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4YU2A Q13627 134 482 763.0 4H5:502 Type1 Active DFGin 7.126 14.681 BLAminus -128.42, 169.74 66.24, 87.83 -106.58, 30.41 288.45, 76.74 -70.77, -21.27 in-in in 8.585 Saltbr-in 2.926 HRD-in -65.53, -46.44 78.54, 3.05 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.92, 172.99 APE9-dihe-na 68.27, 148.59 APE8-dihe-in -64.99, 149.49 APE8-rot-in 273.44 APE67-dihe-in -60.93, -28.26 -62.53, -43.49 APE12-dist-in 12.736 APE11-dist-in 11.533 APE10-dist-in 7.136 APE9-dist-in 3.121 None PTR321 PTR321 XRAY 2.9 0.245 0.277 A 361 349 0 0 0 0 [[159, 479]] 1.0 4yu2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4YU2B Q13627 134 481 763.0 4H5:502 Type1 Active DFGin 7.151 14.752 BLAminus -128.64, 169.94 65.22, 90.88 -106.36, 30.6 290.28, 73.66 -70.15, -21.89 in-in in 8.572 Saltbr-in 2.91 HRD-in -64.42, -46.95 79.44, 4.22 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.9, 173.47 APE9-dihe-na 67.52, 148.21 APE8-dihe-in -62.89, 148.04 APE8-rot-in 274.18 APE67-dihe-in -57.33, -29.6 -62.96, -44.24 APE12-dist-in 12.881 APE11-dist-in 11.9 APE10-dist-in 7.282 APE9-dist-in 3.117 None PTR321 PTR321 XRAY 2.9 0.245 0.277 B 361 348 0 0 0 0 [[159, 479]] 1.0 4yu2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4YU2C Q13627 135 481 763.0 4H5:502 Type1 Active DFGin 7.149 14.733 BLAminus -129.97, 170.39 64.97, 89.04 -105.39, 29.51 288.7, 75.12 -70.27, -20.52 in-in in 8.571 Saltbr-in 2.901 HRD-in -64.55, -48.15 80.68, 1.77 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.0, 173.91 APE9-dihe-na 67.18, 147.22 APE8-dihe-in -64.46, 149.75 APE8-rot-in 272.34 APE67-dihe-in -59.78, -28.43 -63.46, -43.86 APE12-dist-in 12.803 APE11-dist-in 11.599 APE10-dist-in 7.196 APE9-dist-in 3.145 None PTR321 PTR321 XRAY 2.9 0.245 0.277 C 361 347 0 0 0 0 [[159, 479]] 1.0 4yu2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4YU2D Q13627 135 481 763.0 4H5:501 Type1 Active DFGin 7.149 14.755 BLAminus -129.65, 170.04 63.79, 89.4 -106.1, 29.98 289.31, 74.3 -69.85, -20.2 in-in in 8.582 Saltbr-in 2.925 HRD-in -65.3, -48.21 80.59, 2.84 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.24, 173.34 APE9-dihe-na 67.44, 148.12 APE8-dihe-in -63.59, 148.85 APE8-rot-in 273.83 APE67-dihe-in -59.42, -28.15 -62.28, -44.56 APE12-dist-in 12.806 APE11-dist-in 11.569 APE10-dist-in 7.234 APE9-dist-in 3.121 None PTR321 PTR321 XRAY 2.9 0.245 0.277 D 361 347 0 0 0 0 [[159, 479]] 1.0 4yu2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6QU2A Q13627 134 482 763.0 JHW:506 Type1 Active DFGin 6.982 14.589 BLAminus -117.63, 177.32 58.78, 78.21 -94.48, 27.81 290.76, 75.74 -69.1, -16.2 in-in in 8.568 Saltbr-in 2.854 HRD-in -61.74, -43.97 72.49, -0.84 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.02, 172.07 APE9-dihe-na 71.62, 149.26 APE8-dihe-in -69.7, 147.81 APE8-rot-in 285.05 APE67-dihe-in -59.57, -29.32 -59.04, -45.45 APE12-dist-in 12.878 APE11-dist-in 11.444 APE10-dist-in 7.011 APE9-dist-in 3.089 None PTR321 PTR321 XRAY 2.9 0.204 0.242 A 361 349 0 0 0 0 [[159, 479]] 1.0 6qu2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6QU2B Q13627 134 482 763.0 JHW:508 Type1 Active DFGin 7.005 14.638 BLAminus -117.89, 176.82 58.51, 78.25 -94.64, 27.55 290.8, 75.81 -68.12, -17.63 in-in in 8.561 Saltbr-in 2.852 HRD-in -61.86, -43.77 71.78, 1.07 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.33, 172.98 APE9-dihe-na 71.69, 147.87 APE8-dihe-in -69.83, 147.77 APE8-rot-in 285.59 APE67-dihe-in -59.33, -29.5 -59.31, -45.22 APE12-dist-in 12.876 APE11-dist-in 11.482 APE10-dist-in 7.021 APE9-dist-in 3.097 None PTR321 PTR321 XRAY 2.9 0.204 0.242 B 361 349 0 0 0 0 [[159, 479]] 1.0 6qu2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6QU2C Q13627 134 482 763.0 JHW:505 Type1 Active DFGin 7.004 14.655 BLAminus -118.42, 176.92 59.0, 78.18 -94.14, 27.62 291.21, 74.99 -69.86, -15.95 in-in in 8.578 Saltbr-in 2.854 HRD-in -61.48, -44.17 72.54, -0.44 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.57, 172.15 APE9-dihe-na 71.25, 147.44 APE8-dihe-in -70.36, 148.07 APE8-rot-in 286.47 APE67-dihe-in -59.29, -29.31 -59.04, -45.15 APE12-dist-in 12.889 APE11-dist-in 11.507 APE10-dist-in 7.035 APE9-dist-in 3.102 None PTR321 PTR321 XRAY 2.9 0.204 0.242 C 361 349 0 0 0 0 [[159, 479]] 1.0 6qu2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6QU2D Q13627 134 482 763.0 JHW:504 Type1 Active DFGin 6.989 14.664 BLAminus -118.28, 176.89 59.45, 77.75 -95.14, 28.05 290.79, 75.43 -69.23, -15.75 in-in in 8.547 Saltbr-in 2.858 HRD-in -61.16, -43.94 72.27, -0.05 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.09, 173.93 APE9-dihe-na 71.93, 148.3 APE8-dihe-in -68.69, 147.47 APE8-rot-in 287.5 APE67-dihe-in -59.03, -30.52 -59.66, -44.67 APE12-dist-in 13.01 APE11-dist-in 11.567 APE10-dist-in 7.068 APE9-dist-in 3.083 None PTR321 PTR321 XRAY 2.9 0.204 0.242 D 361 349 0 0 0 0 [[159, 479]] 1.0 6qu2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6S11A Q13627 134 480 763.0 KQE:502 Type1 Active DFGin 7.296 14.892 BLAminus -121.55, 164.1 72.87, 91.72 -105.74, 27.5 285.62, 74.33 -70.05, -23.97 in-in in 8.616 Saltbr-in 2.709 HRD-in -66.61, -45.0 72.81, 4.62 in-in-in SNCiii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.87, 171.94 APE9-dihe-na 69.56, 141.33 APE8-dihe-in -63.19, 142.1 APE8-rot-in 291.08 APE67-dihe-in -52.63, -29.59 -57.6, -48.58 APE12-dist-in 13.815 APE11-dist-in 12.051 APE10-dist-in 7.349 APE9-dist-in 3.108 None PTR321 PTR321 XRAY 2.445 0.173 0.21 A 361 344 3 0 0 0 [[159, 479]] 1.0 6s11 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6S14A Q13627 135 481 763.0 KQW:507 Type1 Active DFGin 7.13 14.977 BLAminus -123.96, 169.43 73.07, 84.58 -102.85, 20.91 291.79, 78.47 -63.29, -31.08 in-in in 9.011 Saltbr-in 2.877 HRD-in -63.2, -46.68 75.3, 0.69 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.87, 164.58 APE9-dihe-na 76.07, 137.75 APE8-dihe-in -69.45, 143.91 APE8-rot-in 292.55 APE67-dihe-in -62.58, -24.67 -53.32, -47.34 APE12-dist-in 13.009 APE11-dist-in 10.9 APE10-dist-in 7.342 APE9-dist-in 3.258 None PTR321 PTR321 XRAY 1.05 0.151 0.163 A 361 340 7 0 0 0 [[159, 479]] 1.0 6s14 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6S17A Q13627 134 482 763.0 KQK:511 Type1 Active DFGin 7.203 14.902 BLAminus -124.45, 170.29 74.07, 85.62 -100.56, 16.05 291.39, 79.57 -63.97, -27.96 in-in in 8.995 Saltbr-in 2.873 HRD-in -63.13, -46.99 76.01, -0.62 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.8, 167.89 APE9-dihe-na 76.24, 136.82 APE8-dihe-in -67.42, 143.38 APE8-rot-in 293.12 APE67-dihe-in -63.63, -24.34 -54.34, -45.56 APE12-dist-in 13.102 APE11-dist-in 11.031 APE10-dist-in 7.433 APE9-dist-in 3.273 None PTR321 PTR321 XRAY 1.1 0.15 0.163 A 361 343 6 0 0 0 [[159, 479]] 1.0 6s17 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6S1BA Q13627 135 481 763.0 KRQ:507 Type1 Active DFGin 7.172 14.948 BLAminus -124.63, 169.27 74.75, 83.95 -103.32, 20.44 289.63, 79.43 -66.28, -30.23 in-in in 9.009 Saltbr-in 2.898 HRD-in -65.04, -45.97 75.32, -1.48 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.45, 158.87 APE9-dihe-na 81.09, 137.58 APE8-dihe-in -68.39, 146.11 APE8-rot-in 293.06 APE67-dihe-in -61.74, -25.57 -57.01, -46.7 APE12-dist-in 13.222 APE11-dist-in 11.017 APE10-dist-in 7.629 APE9-dist-in 3.282 None PTR321 PTR321 XRAY 1.3 0.162 0.179 A 361 338 9 0 0 0 [[159, 479]] 1.0 6s1b Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6S1HA Q13627 135 480 763.0 KQZ:504 Type1 Active DFGin 7.168 15.058 BLAminus -123.34, 170.35 73.43, 83.33 -101.5, 17.61 288.45, 79.73 -69.15, -23.93 in-in in 8.678 Saltbr-in 2.895 HRD-in -62.49, -46.68 75.7, -2.5 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.52, 161.84 APE9-dihe-na 78.83, 139.23 APE8-dihe-in -69.82, 141.58 APE8-rot-in 292.61 APE67-dihe-in -62.66, -23.51 -50.81, -48.04 APE12-dist-in 13.048 APE11-dist-in 11.013 APE10-dist-in 7.586 APE9-dist-in 3.222 None PTR321 PTR321 XRAY 1.05 0.141 0.154 A 361 340 6 0 0 0 [[159, 479]] 1.0 6s1h Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6S1IA Q13627 135 481 763.0 KR8:503 Type1 Active DFGin 6.898 14.588 BLAminus -126.45, 178.1 62.9, 78.82 -94.61, 26.34 284.66, 74.88 -61.34, -34.33 in-in in 8.697 Saltbr-in 2.792 HRD-in -63.27, -44.28 74.47, -2.25 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.45, 164.14 APE9-dihe-na 77.6, 145.17 APE8-dihe-in -67.72, 141.59 APE8-rot-in 292.76 APE67-dihe-in -56.98, -28.19 -56.25, -45.01 APE12-dist-in 12.54 APE11-dist-in 11.114 APE10-dist-in 6.989 APE9-dist-in 3.126 None PTR321 PTR321 XRAY 2.38 0.202 0.228 A 361 347 0 0 0 0 [[159, 479]] 1.0 6s1i Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6S1IB Q13627 135 481 763.0 KR8:505 Type1 Active DFGin 6.965 14.548 BLAminus -125.09, 179.13 61.73, 80.78 -98.89, 25.32 290.26, 72.62 -61.57, -38.18 in-in in 8.772 Saltbr-in 2.834 HRD-in -65.26, -46.98 75.17, -0.72 in-in-in SNCiii in-in ActLoopNT-in 2.741 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.9, 162.85 APE9-dihe-na 78.18, 146.19 APE8-dihe-in -67.03, 141.99 APE8-rot-in 283.82 APE67-dihe-in -57.88, -29.55 -55.88, -45.14 APE12-dist-in 12.921 APE11-dist-in 11.64 APE10-dist-in 7.231 APE9-dist-in 3.076 None PTR321 PTR321 XRAY 2.38 0.202 0.228 B 361 346 1 0 0 0 [[159, 479]] 1.0 6s1i Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6S1IC Q13627 135 481 763.0 KR8:505 Type1 Active DFGin 6.883 14.386 BLAminus -125.8, 178.51 61.15, 80.81 -97.76, 24.92 289.88, 75.99 -62.3, -32.74 in-in in 8.686 Saltbr-in 2.628 HRD-in -64.62, -43.93 75.06, -0.23 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.77, 158.73 APE9-dihe-na 76.8, 143.9 APE8-dihe-in -70.32, 140.69 APE8-rot-in 292.97 APE67-dihe-in -57.82, -29.55 -55.13, -45.7 APE12-dist-in 12.064 APE11-dist-in 10.094 APE10-dist-in 6.727 APE9-dist-in 3.071 None PTR321 PTR321 XRAY 2.38 0.202 0.228 C 361 345 2 0 0 1 [[159, 479]] 1.0 6s1i Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6S1ID Q13627 135 481 763.0 KR8:503 Type1 Active DFGin 6.958 14.617 BLAminus -125.25, 179.89 61.35, 78.92 -97.88, 24.63 284.55, 81.3 -62.38, -32.93 in-in in 8.646 Saltbr-in 2.758 HRD-in -63.56, -43.98 75.67, -1.81 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.5, 163.63 APE9-dihe-na 78.26, 147.78 APE8-dihe-in -66.75, 142.12 APE8-rot-in 283.64 APE67-dihe-in -57.25, -28.8 -57.5, -45.09 APE12-dist-in 13.463 APE11-dist-in 12.008 APE10-dist-in 7.185 APE9-dist-in 3.177 None PTR321 PTR321 XRAY 2.38 0.202 0.228 D 361 346 1 0 0 1 [[159, 479]] 1.0 6s1i Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6S1JA Q13627 134 480 763.0 KRK:501 Type1 Active DFGin 7.155 14.926 BLAminus -128.6, 173.02 72.92, 83.09 -103.37, 19.39 290.16, 84.03 -67.23, -28.05 in-in in 8.909 Saltbr-in 2.826 HRD-in -61.93, -50.27 77.88, -1.33 in-in-in SNCiii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.93, 162.86 APE9-dihe-na 76.64, 138.24 APE8-dihe-in -70.1, 144.21 APE8-rot-in 289.47 APE67-dihe-in -65.12, -21.74 -55.6, -43.87 APE12-dist-in 12.93 APE11-dist-in 10.885 APE10-dist-in 7.495 APE9-dist-in 3.218 None PTR321 PTR321 XRAY 1.408 0.156 0.176 A 361 341 6 0 0 0 [[159, 479]] 1.0 6s1j Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6T6AA Q13627 135 481 763.0 MLW:507 Type1 Active DFGin 7.075 14.643 BLAminus -121.66, 177.98 61.35, 75.17 -93.42, 30.57 286.52, 74.8 -78.3, -5.71 in-in in 8.645 Saltbr-in 2.954 HRD-in -61.63, -44.5 74.44, -4.8 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.2, 170.61 APE9-dihe-na 76.22, 146.16 APE8-dihe-in -67.8, 145.05 APE8-rot-in 269.7 APE67-dihe-in -62.62, -23.02 -60.27, -42.85 APE12-dist-in 12.766 APE11-dist-in 11.362 APE10-dist-in 7.034 APE9-dist-in 3.13 None PTR321 PTR321 XRAY 2.8 0.207 0.242 A 361 347 0 0 0 0 [[159, 479]] 1.0 6t6a Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6T6AB Q13627 135 481 763.0 MLW:506 Type1 Active DFGin 7.084 14.663 BLAminus -123.66, 178.07 61.12, 75.8 -93.78, 29.12 285.48, 75.25 -75.0, -7.67 in-in in 8.628 Saltbr-in 2.944 HRD-in -61.02, -44.18 75.29, -4.75 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.29, 171.86 APE9-dihe-na 76.73, 147.09 APE8-dihe-in -66.82, 144.9 APE8-rot-in 270.05 APE67-dihe-in -62.24, -23.36 -61.66, -42.17 APE12-dist-in 12.868 APE11-dist-in 11.504 APE10-dist-in 7.122 APE9-dist-in 3.121 None PTR321 PTR321 XRAY 2.8 0.207 0.242 B 361 347 0 0 0 0 [[159, 479]] 1.0 6t6a Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6T6AC Q13627 135 481 763.0 MLW:506 Type1 Active DFGin 7.041 14.592 BLAminus -124.36, 178.1 60.98, 75.42 -93.3, 29.52 285.85, 76.28 -78.87, -5.76 in-in in 8.642 Saltbr-in 2.936 HRD-in -63.57, -44.17 76.99, -6.26 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.62, 170.81 APE9-dihe-na 77.22, 146.49 APE8-dihe-in -67.43, 144.4 APE8-rot-in 270.2 APE67-dihe-in -62.89, -21.64 -59.6, -42.66 APE12-dist-in 12.786 APE11-dist-in 11.421 APE10-dist-in 7.043 APE9-dist-in 3.126 None PTR321 PTR321 XRAY 2.8 0.207 0.242 C 361 347 0 0 0 0 [[159, 479]] 1.0 6t6a Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6UWYA Q13627 135 481 763.0 QKG:501 Type1 Active DFGin 7.239 14.867 BLAminus -132.26, 176.05 58.86, 71.25 -90.67, 13.27 278.59, 82.94 -60.39, -40.77 in-in in 8.735 Saltbr-in 3.081 HRD-in -61.71, -47.36 76.81, -2.22 in-in-in SNCiii in-in ActLoopNT-in 2.655 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.12, 167.04 APE9-dihe-na 74.27, 150.88 APE8-dihe-in -72.73, 138.41 APE8-rot-in 284.49 APE67-dihe-in -57.43, -28.19 -49.04, -49.4 APE12-dist-in 12.812 APE11-dist-in 11.524 APE10-dist-in 7.209 APE9-dist-in 3.017 None PTR321 PTR321 XRAY 2.95 0.197 0.227 A 361 347 0 0 0 0 [[159, 479]] 1.0 6uwy Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6UWYB Q13627 134 481 763.0 QKG:501 Type1 Active DFGin 7.311 15.09 BLAminus -132.37, 173.46 57.96, 71.45 -90.43, 13.0 277.8, 80.83 -60.37, -40.54 in-in in 8.779 Saltbr-in 3.014 HRD-in -61.63, -47.91 76.71, -1.04 in-in-in SNCiii in-in ActLoopNT-in 2.716 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -63.7, 163.69 APE9-dihe-na 74.19, 154.88 APE8-dihe-in -72.83, 138.38 APE8-rot-in 286.89 APE67-dihe-in -59.92, -29.1 -50.36, -49.5 APE12-dist-in 13.664 APE11-dist-in 11.132 APE10-dist-in 7.037 APE9-dist-in 3.012 None PTR321 PTR321 XRAY 2.95 0.197 0.227 B 361 348 0 0 0 0 [[159, 479]] 1.0 6uwy Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6UWYC Q13627 135 481 763.0 QKG:501 Type1 Active DFGin 7.448 14.961 BLAminus -132.44, 172.18 56.85, 71.63 -90.4, 12.5 280.91, 80.19 -61.16, -41.17 in-in in 8.661 Saltbr-in 2.875 HRD-in -61.46, -47.79 77.42, -2.34 in-in-in SNCiii in-in ActLoopNT-in 2.77 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.48, 167.68 APE9-dihe-na 74.27, 151.37 APE8-dihe-in -72.8, 138.22 APE8-rot-in 285.1 APE67-dihe-in -57.33, -28.79 -48.84, -49.36 APE12-dist-in 12.866 APE11-dist-in 11.736 APE10-dist-in 7.357 APE9-dist-in 3.02 None PTR321 PTR321 XRAY 2.95 0.197 0.227 C 361 347 0 0 0 0 [[159, 479]] 1.0 6uwy Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6UWYD Q13627 134 481 763.0 QKG:501 Type1 Active DFGin 7.138 14.987 BLAminus -133.07, 174.34 57.8, 73.05 -90.03, 14.24 279.65, 81.22 -60.16, -40.68 in-in in 8.748 Saltbr-in 2.975 HRD-in -62.11, -48.37 77.72, -2.5 in-in-in SNCiii in-in ActLoopNT-in 2.725 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.78, 167.27 APE9-dihe-na 74.09, 151.84 APE8-dihe-in -72.45, 137.48 APE8-rot-in 284.95 APE67-dihe-in -57.53, -28.78 -49.33, -49.3 APE12-dist-in 12.8 APE11-dist-in 11.611 APE10-dist-in 7.385 APE9-dist-in 3.072 None PTR321 PTR321 XRAY 2.95 0.197 0.227 D 361 348 0 0 0 0 [[159, 479]] 1.0 6uwy Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8R8EB Q13627 135 481 763.0 YOX:502 Type1 Active DFGin 7.069 14.684 BLAminus -127.98, 172.63 62.79, 73.8 -88.81, 28.19 285.67, 76.47 -75.54, -11.12 in-in in 8.71 Saltbr-in 2.951 HRD-in -62.54, -47.06 75.87, -2.9 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.14, 171.54 APE9-dihe-na 74.42, 146.08 APE8-dihe-in -67.71, 141.78 APE8-rot-in 282.59 APE67-dihe-in -59.51, -26.74 -54.99, -45.67 APE12-dist-in 12.585 APE11-dist-in 11.047 APE10-dist-in 6.756 APE9-dist-in 3.113 None PTR321 PTR321 XRAY 2.22 0.2 0.234 B 361 347 0 0 0 0 [[159, 479]] 1.0 8r8e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8R8EC Q13627 136 481 763.0 YOX:502 Type1 Active DFGin 7.188 14.623 BLAminus -130.04, 167.44 62.25, 73.8 -89.0, 26.94 285.37, 75.31 -74.67, -11.09 in-in in 8.643 Saltbr-in 2.589 HRD-in -61.57, -46.23 75.55, -3.28 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.37, 171.41 APE9-dihe-na 75.31, 148.56 APE8-dihe-in -65.26, 141.68 APE8-rot-in 281.12 APE67-dihe-in -59.77, -26.63 -54.67, -46.17 APE12-dist-in 12.705 APE11-dist-in 11.607 APE10-dist-in 7.189 APE9-dist-in 3.167 None PTR321 PTR321 XRAY 2.22 0.2 0.234 C 361 346 0 0 0 0 [[159, 479]] 1.0 8r8e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8R8ED Q13627 135 480 763.0 YOX:501 Type1 Active DFGin 7.027 14.622 BLAminus -127.82, 174.49 61.5, 72.32 -89.25, 27.64 284.65, 74.88 -76.43, -9.3 in-in in 8.69 Saltbr-in 2.92 HRD-in -62.74, -44.79 74.53, -3.37 in-in-in SNCiii in-in ActLoopNT-in 2.679 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.28, 171.24 APE9-dihe-na 73.58, 146.12 APE8-dihe-in -67.75, 140.76 APE8-rot-in 279.97 APE67-dihe-in -58.05, -26.12 -56.64, -45.76 APE12-dist-in 12.399 APE11-dist-in 11.386 APE10-dist-in 6.834 APE9-dist-in 3.119 None None None XRAY 2.22 0.2 0.234 D 361 346 0 0 0 0 [[159, 479]] 1.0 8r8e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7FHSB Q13627 134 481 763.0 4VZ:501 Type1 Active DFGin 7.385 15.0 BLAminus -125.73, 165.21 71.88, 83.89 -101.28, 23.85 281.27, 80.83 -70.35, -20.86 in-in in 8.799 Saltbr-in 2.715 HRD-in -62.95, -48.52 82.4, -4.32 in-in-in SNCiii in-in ActLoopNT-in 2.785 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.22, 160.69 APE9-dihe-na 79.18, 154.0 APE8-dihe-in -69.6, 130.45 APE8-rot-in 276.76 APE67-dihe-in -56.8, -23.49 -48.13, -49.11 APE12-dist-in 13.918 APE11-dist-in 11.969 APE10-dist-in 7.951 APE9-dist-in 3.132 None PTR321 PTR321 XRAY 2.42 0.234 0.275 B 361 342 6 0 0 0 [[159, 479]] 1.0 7fhs Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8T2HA Q13627 136 480 763.0 XIR:500 Type1 Active DFGin 7.123 14.605 BLAminus -125.94, 165.89 75.03, 89.05 -105.39, 23.99 289.74, 76.5 -56.41, -37.08 in-in in 8.48 Saltbr-in 2.687 HRD-in -62.3, -50.05 75.05, 4.64 in-in-in SNCiii in-in ActLoopNT-in 2.748 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.86, 166.87 APE9-dihe-na 78.77, 155.11 APE8-dihe-in -78.67, 140.46 APE8-rot-in 283.75 APE67-dihe-in -58.52, -25.12 -50.9, -49.84 APE12-dist-in 12.322 APE11-dist-in 11.973 APE10-dist-in 7.197 APE9-dist-in 2.99 None PTR321 PTR321 XRAY 1.85 0.166 0.213 A 365 339 6 0 0 0 [[159, 479]] 1.0 8t2h Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.8e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8T2HB Q13627 135 481 763.0 XIR:500 Type1 Active DFGin 7.088 14.58 BLAminus -125.43, 166.77 72.41, 86.02 -100.65, 24.84 288.66, 75.08 -58.03, -34.69 in-in in 8.595 Saltbr-in 2.706 HRD-in -63.58, -50.21 76.67, 2.87 in-in-in SNCiii in-in ActLoopNT-in 2.762 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.51, 170.94 APE9-dihe-na 73.42, 151.8 APE8-dihe-in -77.86, 142.73 APE8-rot-in 295.35 APE67-dihe-in -69.62, -17.55 -49.75, -46.99 APE12-dist-in 12.643 APE11-dist-in 10.708 APE10-dist-in 6.938 APE9-dist-in 3.04 None PTR321 PTR321 XRAY 1.85 0.166 0.213 B 365 342 5 0 0 0 [[159, 479]] 1.0 8t2h Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.8e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 9CY5A Q13627 136 480 763.0 A1A04:500 Type1 Active DFGin 7.147 14.638 BLAminus -122.0, 166.0 76.85, 87.4 -105.55, 21.68 282.78, 84.23 -69.73, -24.49 in-in in 8.504 Saltbr-in 2.313 HRD-in -59.7, -51.34 83.68, -0.54 in-in-in SNCiii in-in ActLoopNT-in 2.771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -96.54, 173.95 APE9-dihe-na 71.15, 158.37 APE8-dihe-in -75.95, 126.8 APE8-rot-in 288.5 APE67-dihe-in -59.95, -29.92 -35.82, -50.5 APE12-dist-in 12.757 APE11-dist-in 12.226 APE10-dist-in 7.349 APE9-dist-in 3.057 None PTR321 PTR321 XRAY 2.49 0.203 0.259 A 365 339 6 0 0 0 [[159, 479]] 1.0 9cy5 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.8e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 9CY5B Q13627 135 481 763.0 A1A04:500 Type1 Active DFGin 7.251 14.584 BLAminus -112.93, 162.83 79.63, 82.51 -96.96, 24.75 288.34, 80.4 -53.23, -41.67 in-in in 8.584 Saltbr-in 2.866 HRD-in -66.43, -49.68 77.31, -1.94 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -92.97, 173.98 APE9-dihe-na 79.25, 156.99 APE8-dihe-in -84.96, 136.04 APE8-rot-in 282.61 APE67-dihe-in -62.99, -28.41 -37.15, -54.75 APE12-dist-in 12.739 APE11-dist-in 12.286 APE10-dist-in 7.174 APE9-dist-in 3.17 None PTR321 PTR321 XRAY 2.49 0.203 0.259 B 365 342 5 0 0 0 [[159, 479]] 1.0 9cy5 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.8e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 3ANRA Q13627 134 481 763.0 HRM:1 Type1 Active DFGin 7.395 14.88 BLAminus -126.97, 175.57 62.29, 87.12 -103.96, 24.02 282.74, 80.66 -67.77, -18.58 in-in in 8.706 Saltbr-in 2.945 HRD-in -59.12, -43.08 70.29, -4.2 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.86, 169.59 APE9-dihe-na 72.59, 157.32 APE8-dihe-in -74.37, 142.22 APE8-rot-in 294.27 APE67-dihe-in -55.49, -26.14 -45.5, -54.94 APE12-dist-in 13.813 APE11-dist-in 12.061 APE10-dist-in 7.955 APE9-dist-in 3.253 None PTR321 PTR321 XRAY 2.6 0.232 0.264 A 368 343 5 0 0 0 [[159, 479]] 1.0 3anr Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4EA Q13627 134 480 763.0 7QQ:1482 Type1 Active DFGin 7.22 14.874 BLAminus -126.54, 177.15 58.69, 94.29 -113.21, 22.28 286.19, 77.0 -59.45, -31.21 in-in in 8.568 Saltbr-in 2.779 HRD-in -64.66, -42.27 66.83, 14.81 in-in-in SNCiii in-in ActLoopNT-in 2.662 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.09, 163.61 APE9-dihe-na 69.48, 158.79 APE8-dihe-in -72.55, 147.75 APE8-rot-in 295.07 APE67-dihe-in -58.22, -29.01 -58.76, -47.93 APE12-dist-in 13.575 APE11-dist-in 11.747 APE10-dist-in 7.974 APE9-dist-in 3.174 None PTR321 PTR321 XRAY 2.68 0.237 0.268 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a4e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4EB Q13627 133 480 763.0 7QQ:1482 Type1 Active DFGin 7.399 14.881 BLAminus -121.24, 173.6 64.11, 83.73 -104.73, 23.57 287.63, 75.52 -70.09, -36.48 in-in in 8.688 Saltbr-in 2.932 HRD-in -51.94, -37.2 69.96, 8.72 in-in-in SNCiii in-in ActLoopNT-in 3.115 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.62, 169.1 APE9-dihe-na 63.21, 149.19 APE8-dihe-in -68.01, 145.26 APE8-rot-in 293.25 APE67-dihe-in -62.27, -28.2 -53.9, -51.02 APE12-dist-in 13.549 APE11-dist-in 11.424 APE10-dist-in 7.915 APE9-dist-in 3.305 None PTR321 PTR321 XRAY 2.68 0.237 0.268 B 368 323 25 0 0 0 [[159, 479]] 1.0 5a4e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4ED Q13627 134 480 763.0 7QQ:1482 Type1 Active DFGin 7.084 14.377 BLAminus -127.03, 161.26 72.91, 98.11 -113.73, 26.73 293.48, 83.38 -71.75, -27.39 in-in in 8.717 Saltbr-in 2.757 HRD-in -62.4, -41.11 73.31, 5.6 in-in-in SNCiii in-in ActLoopNT-in 2.978 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.98, 167.15 APE9-dihe-na 68.52, 159.57 APE8-dihe-in -79.96, 125.33 APE8-rot-in 300.98 APE67-dihe-in -48.76, -38.1 -29.58, -60.85 APE12-dist-in 13.723 APE11-dist-in 11.606 APE10-dist-in 7.713 APE9-dist-in 3.246 None PTR321 PTR321 XRAY 2.68 0.237 0.268 D 368 332 15 0 0 0 [[159, 479]] 1.0 5a4e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4LA Q13627 134 480 763.0 ZC3:1481 Type1 Active DFGin 7.234 14.766 BLAminus -122.38, 174.21 65.08, 93.49 -114.73, 26.8 284.64, 84.62 -79.93, -25.42 in-in in 8.428 Saltbr-in 3.23 HRD-in -65.21, -42.7 75.91, 6.95 in-in-in SNCiii in-in ActLoopNT-in 3.107 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.23, 163.1 APE9-dihe-na 70.58, 145.07 APE8-dihe-in -65.43, 141.62 APE8-rot-in 280.27 APE67-dihe-in -60.3, -30.26 -54.35, -42.8 APE12-dist-in 13.568 APE11-dist-in 11.426 APE10-dist-in 7.797 APE9-dist-in 3.088 None PTR321 PTR321 XRAY 2.73 0.224 0.267 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a4l Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4LD Q13627 134 479 763.0 ZC3:1480 Type1 Active DFGin 7.353 14.577 BLAminus -132.96, 164.11 69.89, 87.22 -105.39, 34.74 291.55, 76.59 -80.25, -34.64 in-in in 8.659 Saltbr-in 2.941 HRD-in -58.1, -45.98 75.95, 3.48 in-in-in SNCiii in-in ActLoopNT-in 3.239 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.1, 161.63 APE9-dihe-na 71.86, 145.21 APE8-dihe-in -54.07, 139.5 APE8-rot-in 266.11 APE67-dihe-in -50.1, -38.91 -55.61, -48.8 APE12-dist-in 13.859 APE11-dist-in 11.794 APE10-dist-in 7.849 APE9-dist-in 3.338 None PTR321 PTR321 XRAY 2.73 0.224 0.267 D 368 335 11 0 0 0 [[159, 479]] 1.0 5a4l Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4QB Q13627 133 480 763.0 Y3L:1482 Type1 Active DFGin 7.332 15.167 BLAminus -119.07, 169.96 69.93, 79.11 -95.25, 24.02 288.84, 81.96 -59.31, -40.09 in-in in 8.8 Saltbr-in 2.743 HRD-in -65.5, -47.61 81.19, 5.21 in-in-in SNCiii in-in ActLoopNT-in 3.026 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.35, 160.28 APE9-dihe-na 76.8, 155.69 APE8-dihe-in -77.08, 143.17 APE8-rot-in 298.14 APE67-dihe-in -56.03, -30.73 -51.27, -50.53 APE12-dist-in 13.619 APE11-dist-in 11.706 APE10-dist-in 7.959 APE9-dist-in 3.304 None PTR321 PTR321 XRAY 2.37 0.208 0.243 B 368 336 12 0 0 0 [[159, 479]] 1.0 5a4q Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4QD Q13627 134 479 763.0 Y3L:1481 Type1 Active DFGin 7.54 14.858 BLAminus -122.22, 174.03 62.3, 86.45 -97.65, 23.49 289.45, 76.37 -75.31, -20.37 in-in in 8.511 Saltbr-in 2.499 HRD-in -56.95, -45.96 79.67, 1.76 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.06, 163.2 APE9-dihe-na 73.87, 148.99 APE8-dihe-in -76.47, 142.42 APE8-rot-in 301.45 APE67-dihe-in -56.86, -27.34 -54.99, -48.13 APE12-dist-in 13.838 APE11-dist-in 11.826 APE10-dist-in 7.868 APE9-dist-in 3.329 None PTR321 PTR321 XRAY 2.37 0.208 0.243 D 368 335 11 0 0 0 [[159, 479]] 1.0 5a4q Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4TA Q13627 134 480 763.0 AJG:1482 Type1 Active DFGin 7.622 15.274 BLAminus -112.24, -178.72 54.59, 84.96 -104.05, 18.94 273.04, 77.95 -59.69, -39.38 in-in in 8.78 Saltbr-in 3.018 HRD-in -67.27, -38.62 73.07, -10.27 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.67, 162.72 APE9-dihe-na 73.04, 147.49 APE8-dihe-in -69.75, 138.1 APE8-rot-in 286.14 APE67-dihe-in -50.27, -34.74 -54.48, -46.81 APE12-dist-in 13.559 APE11-dist-in 11.324 APE10-dist-in 7.72 APE9-dist-in 3.11 None PTR321 PTR321 XRAY 2.15 0.205 0.234 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a4t Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4TB Q13627 133 480 763.0 AJG:1482 Type1 Active DFGin 7.334 14.771 BLAminus -134.42, 173.1 62.66, 77.62 -92.94, 44.39 292.89, 84.38 -83.77, -36.33 in-in in 8.596 Saltbr-in 2.831 HRD-in -64.98, -48.49 78.64, 9.32 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.45, 162.3 APE9-dihe-na 71.65, 143.12 APE8-dihe-in -61.58, 138.14 APE8-rot-in 299.68 APE67-dihe-in -70.11, -29.4 -55.95, -37.08 APE12-dist-in 13.618 APE11-dist-in 11.4 APE10-dist-in 7.822 APE9-dist-in 3.267 None PTR321 PTR321 XRAY 2.15 0.205 0.234 B 368 340 8 0 0 0 [[159, 479]] 1.0 5a4t Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4TD Q13627 134 479 763.0 AJG:1481 Type1 Active DFGin 7.489 14.887 BLAminus -117.21, 169.43 64.47, 80.55 -95.84, 25.37 288.01, 79.35 -68.27, -34.89 in-in in 8.669 Saltbr-in 2.892 HRD-in -67.49, -52.96 80.25, 5.24 in-in-in SNCiii in-in ActLoopNT-in 2.879 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.97, 164.66 APE9-dihe-na 70.52, 150.41 APE8-dihe-in -69.54, 148.58 APE8-rot-in 293.88 APE67-dihe-in -54.65, -28.51 -61.96, -48.11 APE12-dist-in 13.83 APE11-dist-in 11.722 APE10-dist-in 7.927 APE9-dist-in 3.124 None PTR321 PTR321 XRAY 2.15 0.205 0.234 D 368 333 13 0 0 0 [[159, 479]] 1.0 5a4t Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A54A Q13627 134 480 763.0 5PW:1482 Type1 Active DFGin 7.276 15.215 BLAminus -121.5, 177.39 61.3, 86.79 -106.46, 25.28 279.73, 71.96 -65.24, -32.8 in-in in 8.751 Saltbr-in 3.078 HRD-in -53.91, -44.92 70.91, 12.75 in-in-in SNCiii in-in ActLoopNT-in 3.481 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.16, 159.75 APE9-dihe-na 71.58, 162.32 APE8-dihe-in -77.6, 149.66 APE8-rot-in 289.63 APE67-dihe-in -60.85, -34.82 -58.88, -45.26 APE12-dist-in 13.602 APE11-dist-in 11.614 APE10-dist-in 7.831 APE9-dist-in 3.364 None PTR321 PTR321 XRAY 2.63 0.224 0.255 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a54 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A54B Q13627 133 480 763.0 5PW:1482 Type1 Active DFGin 6.963 14.712 BLAminus -134.12, 173.15 68.71, 67.58 -87.74, 26.53 289.52, 85.86 -78.5, -14.3 in-in in 8.811 Saltbr-in 3.073 HRD-in -63.19, -45.3 82.27, -18.93 in-in-in SNCiii in-in ActLoopNT-in 3.486 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.22, 164.07 APE9-dihe-na 69.13, 155.85 APE8-dihe-in -74.78, 146.48 APE8-rot-in 313.35 APE67-dihe-in -58.66, -31.56 -52.07, -50.9 APE12-dist-in 13.415 APE11-dist-in 11.505 APE10-dist-in 7.727 APE9-dist-in 3.182 None PTR321 PTR321 XRAY 2.63 0.224 0.255 B 368 340 8 0 0 0 [[159, 479]] 1.0 5a54 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A54D Q13627 134 479 763.0 5PW:1481 Type1 Active DFGin 7.476 14.887 BLAminus -116.89, 166.35 68.67, 97.95 -113.07, 31.59 286.6, 76.44 -75.63, -31.91 in-in in 8.723 Saltbr-in 3.178 HRD-in -62.68, -45.72 73.35, 10.52 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.93, 164.8 APE9-dihe-na 68.14, 162.71 APE8-dihe-in -79.75, 144.04 APE8-rot-in 293.59 APE67-dihe-in -50.71, -34.46 -57.02, -44.94 APE12-dist-in 13.828 APE11-dist-in 11.81 APE10-dist-in 7.781 APE9-dist-in 3.24 None PTR321 PTR321 XRAY 2.63 0.224 0.255 D 368 335 11 0 0 0 [[159, 479]] 1.0 5a54 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIFA Q13627 134 480 763.0 B5T:501 Type1 Active DFGin 7.715 15.153 BLAminus -108.17, 168.64 68.55, 82.38 -98.62, 28.92 285.39, 77.1 -72.07, -30.89 in-in in 8.846 Saltbr-in 2.978 HRD-in -66.36, -44.8 74.98, 9.71 in-in-in SNCiii in-in ActLoopNT-in 2.782 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.64, 161.63 APE9-dihe-na 71.89, 150.46 APE8-dihe-in -78.88, 144.18 APE8-rot-in 300.04 APE67-dihe-in -58.53, -31.8 -55.12, -42.87 APE12-dist-in 13.989 APE11-dist-in 11.748 APE10-dist-in 7.965 APE9-dist-in 3.281 None PTR321 PTR321 XRAY 2.22 0.22 0.25 A 368 344 3 0 0 0 [[159, 479]] 1.0 6eif Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIJB Q13627 133 480 763.0 B5Z:501 Type1 Active DFGin 7.267 15.528 BLAminus -117.59, 170.7 64.63, 89.36 -107.31, 30.62 285.29, 75.01 -79.8, -27.42 in-in in 9.004 Saltbr-in 3.483 HRD-in -63.56, -41.89 71.27, 6.78 in-in-in SNCiii in-in ActLoopNT-in 2.799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.2, 156.57 APE9-dihe-na 71.57, 144.46 APE8-dihe-in -65.65, 143.73 APE8-rot-in 301.69 APE67-dihe-in -60.34, -27.61 -53.56, -46.19 APE12-dist-in 13.554 APE11-dist-in 11.232 APE10-dist-in 7.686 APE9-dist-in 3.196 None PTR321 PTR321 XRAY 2.42 0.215 0.242 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eij Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIJD Q13627 134 479 763.0 B5Z:501 Type1 Active DFGin 7.495 15.445 BLAminus -110.58, 169.11 63.21, 88.34 -100.92, 29.04 284.12, 76.0 -75.59, -27.16 in-in in 9.051 Saltbr-in 2.765 HRD-in -55.24, -46.68 74.47, 11.33 in-in-in SNCiii in-in ActLoopNT-in 2.95 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.83, 166.58 APE9-dihe-na 66.27, 155.62 APE8-dihe-in -75.66, 150.91 APE8-rot-in 302.31 APE67-dihe-in -58.65, -28.49 -61.4, -47.04 APE12-dist-in 13.802 APE11-dist-in 11.742 APE10-dist-in 7.729 APE9-dist-in 3.253 None PTR321 PTR321 XRAY 2.42 0.215 0.242 D 368 339 7 0 0 0 [[159, 479]] 1.0 6eij Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EILA Q13627 134 480 763.0 B6B:501 Type1 Active DFGin 7.57 14.97 BLAminus -127.99, 168.56 62.9, 83.29 -100.21, 30.13 286.84, 74.94 -73.55, -27.3 in-in in 8.635 Saltbr-in 2.893 HRD-in -66.02, -40.6 72.49, 2.1 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.15, 170.89 APE9-dihe-na 67.45, 153.11 APE8-dihe-in -71.17, 144.45 APE8-rot-in 292.8 APE67-dihe-in -54.25, -24.55 -56.23, -51.45 APE12-dist-in 13.874 APE11-dist-in 11.853 APE10-dist-in 7.986 APE9-dist-in 3.106 None PTR321 PTR321 XRAY 2.465 0.213 0.254 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eil Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIPB Q13627 133 480 763.0 B7B:501 Type1 Active DFGin 7.3 15.137 BLAminus -116.31, 172.99 59.38, 82.91 -97.29, 38.15 294.47, 77.72 -74.08, -35.63 in-in in 9.09 Saltbr-in 2.899 HRD-in -65.81, -47.59 76.49, 9.41 in-in-in SNCiii in-in ActLoopNT-in 3.186 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.16, 160.62 APE9-dihe-na 70.79, 152.01 APE8-dihe-in -70.68, 148.82 APE8-rot-in 294.92 APE67-dihe-in -57.84, -32.79 -60.95, -46.44 APE12-dist-in 13.9 APE11-dist-in 11.499 APE10-dist-in 7.671 APE9-dist-in 3.306 None PTR321 PTR321 XRAY 2.56 0.243 0.266 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIPD Q13627 134 479 763.0 B7B:501 Type1 Active DFGin 7.439 15.077 BLAminus -126.34, 172.93 62.79, 86.26 -101.23, 28.95 288.24, 77.28 -69.9, -27.46 in-in in 8.846 Saltbr-in 2.848 HRD-in -58.79, -41.55 67.62, 10.96 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.57, 164.56 APE9-dihe-na 68.0, 151.01 APE8-dihe-in -69.91, 146.7 APE8-rot-in 286.07 APE67-dihe-in -59.83, -24.78 -58.38, -48.52 APE12-dist-in 13.863 APE11-dist-in 11.61 APE10-dist-in 7.782 APE9-dist-in 3.366 None PTR321 PTR321 XRAY 2.56 0.243 0.266 D 368 333 13 0 0 0 [[159, 479]] 1.0 6eip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIQD Q13627 134 479 763.0 B6Z:501 Type1 Active DFGin 7.574 14.87 BLAminus -119.79, 171.42 62.12, 83.48 -94.95, 33.05 288.92, 76.92 -77.23, -31.31 in-in in 8.77 Saltbr-in 2.825 HRD-in -69.21, -45.78 80.19, 5.53 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.36, 156.34 APE9-dihe-na 80.64, 155.49 APE8-dihe-in -79.45, 139.43 APE8-rot-in 279.91 APE67-dihe-in -60.72, -27.06 -52.76, -47.1 APE12-dist-in 13.959 APE11-dist-in 11.841 APE10-dist-in 7.989 APE9-dist-in 3.232 None PTR321 PTR321 XRAY 2.3 0.22 0.252 D 368 333 13 0 0 0 [[159, 479]] 1.0 6eiq Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EISB Q13627 133 480 763.0 B6N:501 Type1 Active DFGin 7.364 15.01 BLAminus -121.04, 176.25 60.21, 78.92 -98.69, 24.99 286.57, 87.15 -70.6, -24.44 in-in in 8.697 Saltbr-in 2.736 HRD-in -63.78, -47.49 73.12, 4.16 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.07, 170.33 APE9-dihe-na 64.55, 152.61 APE8-dihe-in -67.26, 141.38 APE8-rot-in 300.27 APE67-dihe-in -63.11, -23.65 -52.42, -46.34 APE12-dist-in 13.8 APE11-dist-in 11.772 APE10-dist-in 7.906 APE9-dist-in 3.181 None PTR321 PTR321 XRAY 2.36 0.223 0.262 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eis Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EISD Q13627 134 479 763.0 B6N:501 Type1 Active DFGin 7.286 15.141 BLAminus -125.52, 165.07 68.69, 87.86 -104.24, 31.22 282.79, 81.9 -77.49, -25.71 in-in in 8.619 Saltbr-in 2.657 HRD-in -61.8, -42.91 69.44, 6.24 in-in-in SNCiii in-in ActLoopNT-in 2.742 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.63, 168.78 APE9-dihe-na 66.0, 152.38 APE8-dihe-in -69.65, 137.97 APE8-rot-in 298.51 APE67-dihe-in -59.57, -25.22 -50.11, -45.93 APE12-dist-in 13.975 APE11-dist-in 11.877 APE10-dist-in 7.865 APE9-dist-in 3.336 None PTR321 PTR321 XRAY 2.36 0.223 0.262 D 368 339 7 0 0 0 [[159, 479]] 1.0 6eis Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EJ4C Q13627 135 479 763.0 B7W:501 Type1 Active DFGin 7.399 14.621 BLAminus -127.52, 168.2 60.93, 96.68 -107.48, 20.89 285.11, 74.4 -57.11, -40.86 in-in in 9.022 Saltbr-in 2.977 HRD-in -60.32, -39.77 73.57, -0.65 in-in-in SNCiii in-in ActLoopNT-in 3.283 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.12, 159.98 APE9-dihe-na 72.27, 158.6 APE8-dihe-in -74.01, 154.25 APE8-rot-in 280.21 APE67-dihe-in -64.21, -35.15 -55.76, -52.46 APE12-dist-in 13.833 APE11-dist-in 11.799 APE10-dist-in 7.982 APE9-dist-in 3.286 None PTR321 PTR321 XRAY 2.88 0.222 0.27 C 368 332 13 0 0 0 [[159, 479]] 1.0 6ej4 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6YF8A Q13627 134 480 763.0 OPW:501 Type1 Active DFGin 7.367 15.037 BLAminus -107.79, 169.33 69.2, 81.79 -99.28, 28.66 285.18, 77.14 -72.43, -31.23 in-in in 8.601 Saltbr-in 2.847 HRD-in -65.51, -44.05 74.67, 9.56 in-in-in SNCiii in-in ActLoopNT-in 2.722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.05, 162.23 APE9-dihe-na 71.89, 151.15 APE8-dihe-in -78.29, 144.29 APE8-rot-in 300.07 APE67-dihe-in -58.27, -31.82 -55.32, -42.67 APE12-dist-in 13.883 APE11-dist-in 11.463 APE10-dist-in 7.639 APE9-dist-in 3.269 None PTR321 PTR321 XRAY 3.198 0.251 0.283 A 368 342 5 0 0 0 [[159, 479]] 1.0 6yf8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6YF8B Q13627 133 480 763.0 OPW:501 Type1 Active DFGin 7.35 14.819 BLAminus -117.64, 170.81 65.81, 81.87 -100.82, 27.57 293.99, 81.4 -77.25, -30.97 in-in in 8.702 Saltbr-in 2.634 HRD-in -63.24, -42.07 74.0, 14.09 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.69, 162.87 APE9-dihe-na 65.58, 155.56 APE8-dihe-in -69.5, 152.58 APE8-rot-in 294.46 APE67-dihe-in -60.85, -36.35 -65.13, -40.78 APE12-dist-in 13.566 APE11-dist-in 11.269 APE10-dist-in 7.757 APE9-dist-in 3.284 None PTR321 PTR321 XRAY 3.198 0.251 0.283 B 368 340 8 0 0 0 [[159, 479]] 1.0 6yf8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6YF8D Q13627 134 479 763.0 OPW:501 Type1 Active DFGin 7.163 14.672 BLAminus -129.06, 157.06 74.04, 87.38 -102.12, 32.5 287.46, 75.26 -75.18, -28.37 in-in in 8.607 Saltbr-in 3.368 HRD-in -62.03, -42.61 74.97, 8.8 in-in-in SNCiii in-in ActLoopNT-in 3.009 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.1, 162.77 APE9-dihe-na 71.6, 148.13 APE8-dihe-in -72.02, 126.06 APE8-rot-in 276.95 APE67-dihe-in -35.21, -29.98 -36.67, -74.72 APE12-dist-in 13.536 APE11-dist-in 11.438 APE10-dist-in 7.66 APE9-dist-in 3.254 None PTR321 PTR321 XRAY 3.198 0.251 0.283 D 368 331 15 0 0 0 [[159, 479]] 1.0 6yf8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7Z5NA Q13627 135 480 763.0 3NG:501 Type1 Active DFGin 7.332 14.774 BLAminus -125.89, 175.46 60.34, 76.96 -90.72, 25.89 277.64, 75.8 -70.85, -23.55 in-in in 8.867 Saltbr-in 2.627 HRD-in -70.94, -45.64 77.0, -3.79 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.65, -35.2 APE9-dihe-na -94.12, 169.14 APE8-dihe-in -81.45, 135.48 APE8-rot-in 271.72 APE67-dihe-in -57.78, -21.85 -42.59, -54.66 APE12-dist-in 12.682 APE11-dist-in 11.088 APE10-dist-in 6.808 APE9-dist-in 3.373 None PTR321 PTR321 XRAY 2.77 0.207 0.252 A 370 346 0 0 0 0 [[159, 479]] 1.0 7z5n Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7Z5NB Q13627 135 480 763.0 3NG:501 Type1 Active DFGin 6.965 15.03 BLAminus -121.53, 177.86 59.36, 74.88 -91.0, 24.04 284.65, 79.36 -69.42, -6.51 in-in in 9.072 Saltbr-in 2.955 HRD-in -65.31, -40.72 67.91, 3.75 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.86, 165.14 APE9-dihe-na 70.53, 140.66 APE8-dihe-in -62.36, 145.8 APE8-rot-in 271.48 APE67-dihe-in -55.51, -24.3 -55.08, -48.98 APE12-dist-in 12.652 APE11-dist-in 11.24 APE10-dist-in 7.392 APE9-dist-in 3.193 None PTR321 PTR321 XRAY 2.77 0.207 0.252 B 370 343 3 0 0 0 [[159, 479]] 1.0 7z5n Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7Z5NC Q13627 134 480 763.0 3NG:501 Type1 Active DFGin 7.125 14.845 BLAminus -127.45, -179.8 54.81, 79.63 -96.7, 25.59 287.09, 79.21 -71.97, -4.29 in-in in 9.218 Saltbr-in 2.931 HRD-in -65.84, -47.16 77.48, 0.17 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.48, 175.3 APE9-dihe-na 70.69, 141.68 APE8-dihe-in -71.86, 144.08 APE8-rot-in 308.65 APE67-dihe-in -60.2, -32.88 -49.5, -49.8 APE12-dist-in 13.034 APE11-dist-in 11.534 APE10-dist-in 7.148 APE9-dist-in 3.171 None PTR321 PTR321 XRAY 2.77 0.207 0.252 C 370 344 3 0 0 0 [[159, 479]] 1.0 7z5n Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7Z5ND Q13627 135 480 763.0 3NG:501 Type1 Active DFGin 7.13 14.89 BLAminus -128.02, 175.09 60.57, 71.33 -86.84, 26.43 281.73, 81.64 -75.1, -14.91 in-in in 9.081 Saltbr-in 2.672 HRD-in -60.22, -35.39 67.3, 3.71 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -92.57, 171.93 APE9-dihe-na 66.97, 156.51 APE8-dihe-in -85.5, 144.03 APE8-rot-in 283.59 APE67-dihe-in -57.76, -18.64 -49.19, -52.69 APE12-dist-in 12.39 APE11-dist-in 10.732 APE10-dist-in 7.111 APE9-dist-in 3.042 None PTR321 PTR321 XRAY 2.77 0.207 0.252 D 370 338 8 0 0 0 [[159, 479]] 1.0 7z5n Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7Z5NE Q13627 135 480 763.0 3NG:501 Type1 Active DFGin 7.188 14.841 BLAminus -123.41, -179.95 58.6, 74.9 -91.66, 28.87 284.52, 74.3 -74.18, -15.86 in-in in 8.932 Saltbr-in 2.599 HRD-in -66.53, -45.73 70.01, 6.86 in-in-in SNCiii in-in ActLoopNT-in 2.729 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.5, 169.99 APE9-dihe-na 69.78, 136.41 APE8-dihe-in -57.94, 135.93 APE8-rot-in 298.8 APE67-dihe-in -52.87, -33.29 -49.91, -51.82 APE12-dist-in 12.549 APE11-dist-in 11.378 APE10-dist-in 7.325 APE9-dist-in 3.185 None PTR321 PTR321 XRAY 2.77 0.207 0.252 E 370 340 6 0 0 0 [[159, 479]] 1.0 7z5n Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7Z5NF Q13627 135 480 763.0 3NG:501 Type1 Active DFGin 7.268 14.5 BLAminus -134.01, 179.07 56.51, 71.89 -90.03, 23.99 289.58, 70.49 -65.64, -23.07 in-in in 9.224 Saltbr-in 2.867 HRD-in -69.65, -42.1 76.58, -5.06 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.88, -177.32 APE9-dihe-na 69.42, 90.94 APE8-dihe-in -27.36, 123.58 APE8-rot-in 265.98 APE67-dihe-in -50.43, -31.45 -50.21, -44.01 APE12-dist-in 13.065 APE11-dist-in 11.252 APE10-dist-in 6.846 APE9-dist-in 3.171 None PTR321 PTR321 XRAY 2.77 0.207 0.252 F 370 346 0 0 0 0 [[159, 479]] 1.0 7z5n Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7Z5NG Q13627 137 480 763.0 3NG:501 Type1 Active DFGin 7.344 14.781 BLAminus -131.27, 177.34 58.91, 64.55 -81.55, 37.12 289.02, 78.81 -81.79, -16.85 in-in in 8.979 Saltbr-in 2.629 HRD-in -65.23, -49.26 77.2, 4.64 in-in-in SNCiii in-in ActLoopNT-in 2.719 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.89, 64.11 APE9-dihe-na -161.3, 162.4 APE8-dihe-in -70.8, 130.74 APE8-rot-in 279.54 APE67-dihe-in -57.11, -25.99 -52.9, -46.96 APE12-dist-in 12.712 APE11-dist-in 11.544 APE10-dist-in 6.759 APE9-dist-in 3.418 None PTR321 PTR321 XRAY 2.77 0.207 0.252 G 370 333 11 0 0 0 [[159, 479]] 1.0 7z5n Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8C3RA Q13627 135 480 763.0 R7O:501 Type1 Active DFGin 7.582 14.765 BLAminus -123.3, 160.97 61.95, 92.11 -99.77, 29.64 287.05, 71.45 -70.47, -16.78 in-in in 8.52 Saltbr-in 2.774 HRD-in -65.6, -46.48 78.0, 2.34 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.35, 171.73 APE9-dihe-na 71.24, 149.33 APE8-dihe-in -74.45, 145.43 APE8-rot-in 300.61 APE67-dihe-in -59.08, -27.8 -56.43, -44.81 APE12-dist-in 12.402 APE11-dist-in 11.201 APE10-dist-in 7.222 APE9-dist-in 3.222 None PTR321 PTR321 XRAY 2.06 0.187 0.209 A 370 346 0 0 0 0 [[159, 479]] 1.0 8c3r Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8C3RB Q13627 136 480 763.0 R7O:501 Type1 Active DFGin 7.136 14.811 BLAminus -123.29, 167.45 65.44, 80.19 -97.63, 28.79 287.96, 74.69 -68.15, -22.5 in-in in 8.662 Saltbr-in 2.942 HRD-in -67.34, -39.55 70.0, 7.08 in-in-in SNCiii in-in ActLoopNT-in 2.703 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.04, 166.27 APE9-dihe-na 72.62, 139.21 APE8-dihe-in -62.23, 144.37 APE8-rot-in 295.1 APE67-dihe-in -57.99, -27.22 -56.76, -45.19 APE12-dist-in 12.555 APE11-dist-in 10.994 APE10-dist-in 7.329 APE9-dist-in 3.225 None PTR321 PTR321 XRAY 2.06 0.187 0.209 B 370 345 0 0 0 0 [[159, 479]] 1.0 8c3r Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8C3GA Q13627 134 480 763.0 QS0:501 Type1 Active DFGin 7.743 15.056 BLAminus -122.4, 159.11 70.62, 87.46 -99.56, 24.8 280.34, 73.41 -66.95, -22.86 in-in in 8.66 Saltbr-in 2.906 HRD-in -63.26, -48.03 79.68, -2.67 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.78, 166.89 APE9-dihe-na 73.47, 141.67 APE8-dihe-in -65.32, 142.21 APE8-rot-in 286.57 APE67-dihe-in -55.53, -29.43 -49.01, -52.14 APE12-dist-in 13.368 APE11-dist-in 11.339 APE10-dist-in 7.622 APE9-dist-in 3.122 None PTR321 PTR321 XRAY 2.08 0.196 0.237 A 371 344 3 0 0 0 [[159, 479]] 1.0 8c3g Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8C3GB Q13627 134 480 763.0 QS0:501 Type1 Active DFGin 7.619 14.965 BLAminus -126.26, 160.88 70.82, 88.0 -100.32, 24.36 284.04, 76.33 -69.92, -22.03 in-in in 8.69 Saltbr-in 2.709 HRD-in -65.16, -43.7 77.31, -6.37 in-in-in SNCiii in-in ActLoopNT-in 2.72 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.34, 171.66 APE9-dihe-na 68.35, 154.78 APE8-dihe-in -74.32, 140.03 APE8-rot-in 274.86 APE67-dihe-in -57.14, -31.61 -51.55, -47.48 APE12-dist-in 13.897 APE11-dist-in 11.795 APE10-dist-in 7.918 APE9-dist-in 3.068 None PTR321 PTR321 XRAY 2.08 0.196 0.237 B 371 333 14 0 0 0 [[159, 479]] 1.0 8c3g Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8C3GC Q13627 134 480 763.0 QS0:502 Type1 Active DFGin 7.39 14.702 BLAminus -128.69, 158.7 71.6, 91.39 -100.86, 21.74 282.48, 82.23 -71.28, -20.67 in-in in 8.486 Saltbr-in 2.828 HRD-in -70.94, -40.51 73.81, -8.22 in-in-in SNCiii in-in ActLoopNT-in 2.715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.57, 166.28 APE9-dihe-na 71.87, 146.61 APE8-dihe-in -66.83, 145.54 APE8-rot-in 302.42 APE67-dihe-in -61.67, -26.79 -57.09, -43.66 APE12-dist-in 13.613 APE11-dist-in 11.865 APE10-dist-in 7.836 APE9-dist-in 3.181 None PTR321 PTR321 XRAY 2.08 0.196 0.237 C 371 341 6 0 0 0 [[159, 479]] 1.0 8c3g Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8C3GD Q13627 134 480 763.0 QS0:501 Type1 Active DFGin 7.385 14.915 BLAminus -133.23, 162.85 62.78, 88.13 -95.33, 26.44 290.5, 77.86 -68.41, -23.5 in-in in 8.607 Saltbr-in 2.822 HRD-in -60.07, -49.82 78.57, -2.37 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.4, 174.1 APE9-dihe-na 67.56, 148.97 APE8-dihe-in -66.35, 140.59 APE8-rot-in 265.57 APE67-dihe-in -54.42, -30.15 -57.29, -47.59 APE12-dist-in 13.746 APE11-dist-in 12.049 APE10-dist-in 7.901 APE9-dist-in 3.058 None PTR321 PTR321 XRAY 2.08 0.196 0.237 D 371 337 10 0 0 0 [[159, 479]] 1.0 8c3g Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 9FPXA Q13627 136 479 763.0 CC9:501 Type1 Active DFGin 7.639 14.564 BLAminus -128.52, -179.85 64.32, 75.88 -96.77, 27.03 289.01, 77.19 -67.47, -43.12 in-in in 8.672 Saltbr-in 2.767 HRD-in -68.22, -36.96 69.23, -0.41 in-in-in SNCiii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.19, -47.98 APE9-dihe-na -95.05, 163.26 APE8-dihe-in -63.48, 147.02 APE8-rot-in 273.59 APE67-dihe-in -53.12, -33.33 -58.72, -55.68 APE12-dist-in 12.051 APE11-dist-in 10.975 APE10-dist-in 7.128 APE9-dist-in 3.304 None PTR321 PTR321 XRAY 2.69 0.242 0.278 A 371 337 7 0 0 0 [[159, 479]] 1.0 9fpx Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 9FPXB Q13627 143 480 763.0 CC9:501 Type1 Active DFGin 7.491 14.356 BLAminus -125.11, 175.25 58.16, 79.65 -98.94, 25.54 294.99, 76.36 -62.08, -51.42 in-in in 8.96 Saltbr-in 3.042 HRD-in -68.96, -37.47 65.08, 10.01 in-in-in SNCiii in-in ActLoopNT-in 2.43 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.35, 179.3 APE9-dihe-na 69.75, 147.35 APE8-dihe-in -76.68, 135.47 APE8-rot-in 286.81 APE67-dihe-in -53.4, -25.2 -48.11, -54.23 APE12-dist-in 12.133 APE11-dist-in 11.319 APE10-dist-in 7.011 APE9-dist-in 3.215 None PTR321 PTR321 XRAY 2.69 0.242 0.278 B 371 337 1 0 0 0 [[159, 479]] 1.0 9fpx Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 2VX3A Q13627 135 481 763.0 D15:600 Type1 Active DFGin 7.177 14.936 BLAminus -117.81, 179.58 65.92, 72.63 -91.66, 22.61 288.71, 80.01 -64.63, -16.68 in-in in 9.357 Saltbr-in 2.613 HRD-in -69.18, -45.26 74.92, -7.88 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.77, 169.88 APE9-dihe-na 74.29, 146.1 APE8-dihe-in -68.67, 142.33 APE8-rot-in 277.43 APE67-dihe-in -61.53, -28.29 -54.62, -46.41 APE12-dist-in 12.499 APE11-dist-in 11.435 APE10-dist-in 6.965 APE9-dist-in 3.064 None PTR321 PTR321 XRAY 2.4 0.186 0.23 A 382 347 0 0 0 0 [[159, 479]] 1.0 2vx3 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 2VX3B Q13627 135 480 763.0 D15:600 Type1 Active DFGin 7.264 15.037 BLAminus -122.56, -178.04 63.15, 68.41 -88.18, 26.58 286.19, 82.05 -63.3, -25.27 in-in in 9.323 Saltbr-in 2.487 HRD-in -63.29, -48.28 78.74, -5.5 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.98, 169.63 APE9-dihe-na 73.35, 142.01 APE8-dihe-in -64.13, 145.91 APE8-rot-in 293.73 APE67-dihe-in -61.18, -25.64 -59.75, -45.87 APE12-dist-in 12.788 APE11-dist-in 11.481 APE10-dist-in 7.216 APE9-dist-in 3.173 None PTR321 PTR321 XRAY 2.4 0.186 0.23 B 382 341 5 0 0 0 [[159, 479]] 1.0 2vx3 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 2VX3C Q13627 135 480 763.0 D15:600 Type1 Active DFGin 7.171 15.076 BLAminus -121.44, 178.92 62.09, 79.8 -99.68, 23.42 286.42, 75.22 -71.85, -9.09 in-in in 9.284 Saltbr-in 2.559 HRD-in -69.05, -51.28 81.08, -2.28 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.91, 169.36 APE9-dihe-na 73.6, 142.61 APE8-dihe-in -69.05, 142.27 APE8-rot-in 289.71 APE67-dihe-in -57.92, -27.82 -52.31, -50.36 APE12-dist-in 12.693 APE11-dist-in 11.469 APE10-dist-in 7.054 APE9-dist-in 3.198 None PTR321 PTR321 XRAY 2.4 0.186 0.23 C 382 339 7 0 0 0 [[159, 479]] 1.0 2vx3 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 2VX3D Q13627 135 480 763.0 D15:600 Type1 Active DFGin 7.127 15.124 BLAminus -119.03, 173.28 66.12, 79.97 -97.89, 24.65 287.18, 77.93 -62.52, -22.35 in-in in 9.434 Saltbr-in 2.837 HRD-in -59.24, -53.5 80.78, -1.27 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.8, 170.17 APE9-dihe-na 73.1, 153.08 APE8-dihe-in -81.31, 142.62 APE8-rot-in 292.88 APE67-dihe-in -60.26, -27.62 -52.95, -48.14 APE12-dist-in 12.928 APE11-dist-in 11.48 APE10-dist-in 7.18 APE9-dist-in 3.148 None PTR321 PTR321 XRAY 2.4 0.186 0.23 D 382 343 3 0 0 0 [[159, 479]] 1.0 2vx3 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 2WO6A Q13627 133 481 763.0 D15:60600 Type1 Active DFGin 7.448 15.138 BLAminus -113.71, 170.1 69.22, 79.01 -93.27, 30.89 281.47, 79.67 -74.92, -25.98 in-in in 8.538 Saltbr-in 2.478 HRD-in -60.74, -47.85 77.07, -4.65 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.22, 165.87 APE9-dihe-na 75.78, 143.18 APE8-dihe-in -71.63, 143.35 APE8-rot-in 298.65 APE67-dihe-in -54.81, -27.06 -54.61, -51.13 APE12-dist-in 13.979 APE11-dist-in 11.967 APE10-dist-in 7.387 APE9-dist-in 3.275 None PTR321 PTR321 XRAY 2.5 0.19 0.229 A 382 345 4 0 0 0 [[159, 479]] 1.0 2wo6 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 2WO6B Q13627 136 480 763.0 D15:60600 Type1 Active DFGin 7.392 15.045 BLAminus -114.82, 170.21 64.99, 84.74 -96.3, 34.41 283.13, 77.19 -78.24, -22.43 in-in in 9.207 Saltbr-in 2.725 HRD-in -63.58, -44.58 74.08, -1.57 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.01, 169.27 APE9-dihe-na 76.89, 144.45 APE8-dihe-in -76.49, 136.75 APE8-rot-in 283.78 APE67-dihe-in -66.31, -25.74 -49.43, -39.9 APE12-dist-in 12.633 APE11-dist-in 11.105 APE10-dist-in 6.823 APE9-dist-in 3.096 None PTR321 PTR321 XRAY 2.5 0.19 0.229 B 382 340 5 0 0 0 [[159, 479]] 1.0 2wo6 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4AZEA Q13627 132 481 763.0 3RA:700 Type1 Active DFGin 6.953 14.616 BLAminus -137.23, 169.92 67.49, 90.44 -106.39, 23.89 283.3, 71.95 -55.61, -37.62 in-in in 9.01 Saltbr-in 2.812 HRD-in -70.04, -49.18 72.92, 15.43 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.19, 169.65 APE9-dihe-na 74.45, 134.72 APE8-dihe-in -60.37, 136.79 APE8-rot-in 289.06 APE67-dihe-in -57.82, -32.3 -48.27, -49.81 APE12-dist-in 12.265 APE11-dist-in 10.562 APE10-dist-in 6.635 APE9-dist-in 3.256 None SEP301,PTR321 SEP301,PTR321 XRAY 3.15 0.219 0.248 A 382 350 0 0 0 0 [[159, 479]] 1.0 4aze Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4AZEB Q13627 135 481 763.0 3RA:700 Type1 Active DFGin 6.924 14.613 BLAminus -138.16, 169.5 68.4, 90.42 -106.1, 24.2 283.49, 72.02 -57.21, -35.99 in-in in 9.022 Saltbr-in 2.9 HRD-in -69.57, -48.1 73.99, 12.32 in-in-in SNCiii in-in ActLoopNT-in 2.833 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.81, 169.0 APE9-dihe-na 74.6, 134.75 APE8-dihe-in -60.95, 138.61 APE8-rot-in 290.43 APE67-dihe-in -56.44, -36.37 -49.68, -48.78 APE12-dist-in 12.276 APE11-dist-in 10.559 APE10-dist-in 6.631 APE9-dist-in 3.226 None SEP301,PTR321 SEP301,PTR321 XRAY 3.15 0.219 0.248 B 382 347 0 0 0 0 [[159, 479]] 1.0 4aze Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4AZEC Q13627 132 481 763.0 3RA:700 Type1 Active DFGin 6.933 14.607 BLAminus -136.67, 171.08 67.02, 92.32 -107.7, 25.06 283.25, 71.9 -57.45, -37.58 in-in in 9.002 Saltbr-in 2.835 HRD-in -68.51, -50.21 73.5, 15.7 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.49, 169.71 APE9-dihe-na 73.57, 134.86 APE8-dihe-in -60.52, 139.24 APE8-rot-in 289.26 APE67-dihe-in -57.24, -34.82 -50.4, -48.08 APE12-dist-in 12.316 APE11-dist-in 10.569 APE10-dist-in 6.591 APE9-dist-in 3.28 None SEP301,PTR321 SEP301,PTR321 XRAY 3.15 0.219 0.248 C 382 350 0 0 0 0 [[159, 479]] 1.0 4aze Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5AIKA Q13627 134 481 763.0 AWR:900 Type1 Active DFGin 7.488 15.138 BLAminus -123.8, 165.61 68.96, 89.37 -99.53, 20.4 284.53, 79.68 -68.37, -30.16 in-in in 8.457 Saltbr-in 2.716 HRD-in -69.39, -41.54 73.14, 9.89 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.11, 166.6 APE9-dihe-na 72.45, 139.9 APE8-dihe-in -58.6, 139.24 APE8-rot-in 263.46 APE67-dihe-in -61.38, -25.4 -48.26, -51.05 APE12-dist-in 13.515 APE11-dist-in 11.757 APE10-dist-in 7.939 APE9-dist-in 3.238 None PTR321 PTR321 XRAY 2.7 0.228 0.252 A 382 345 3 0 0 0 [[159, 479]] 1.0 5aik Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5AIKB Q13627 134 481 763.0 AWR:900 Type1 Active DFGin 7.471 15.176 BLAminus -125.22, 165.11 67.89, 88.91 -100.53, 21.33 285.51, 80.4 -65.48, -31.48 in-in in 8.424 Saltbr-in 2.707 HRD-in -68.57, -40.82 71.56, 10.16 in-in-in SNCiii in-in ActLoopNT-in 2.777 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.21, 166.46 APE9-dihe-na 73.88, 141.73 APE8-dihe-in -58.72, 138.35 APE8-rot-in 264.56 APE67-dihe-in -61.35, -26.09 -50.07, -49.03 APE12-dist-in 13.527 APE11-dist-in 11.708 APE10-dist-in 7.938 APE9-dist-in 3.208 None PTR321 PTR321 XRAY 2.7 0.228 0.252 B 382 343 5 0 0 0 [[159, 479]] 1.0 5aik Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5AIKC Q13627 134 481 763.0 AWR:900 Type1 Active DFGin 7.496 15.188 BLAminus -123.03, 165.69 69.38, 87.6 -99.21, 19.82 285.24, 79.6 -64.68, -32.8 in-in in 8.455 Saltbr-in 2.713 HRD-in -68.63, -41.21 72.74, 9.64 in-in-in SNCiii in-in ActLoopNT-in 2.787 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.44, 166.36 APE9-dihe-na 71.77, 141.71 APE8-dihe-in -59.81, 140.84 APE8-rot-in 262.61 APE67-dihe-in -60.57, -26.31 -49.76, -50.14 APE12-dist-in 13.385 APE11-dist-in 11.642 APE10-dist-in 7.885 APE9-dist-in 3.217 None PTR321 PTR321 XRAY 2.7 0.228 0.252 C 382 343 5 0 0 0 [[159, 479]] 1.0 5aik Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5AIKD Q13627 134 480 763.0 AWR:900 Type1 Active DFGin 7.476 15.15 BLAminus -124.79, 165.65 68.79, 87.65 -99.81, 21.12 284.88, 80.68 -66.8, -31.32 in-in in 8.421 Saltbr-in 2.707 HRD-in -68.57, -41.65 72.65, 9.66 in-in-in SNCiii in-in ActLoopNT-in 2.78 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.19, 166.91 APE9-dihe-na 72.86, 141.73 APE8-dihe-in -58.81, 138.66 APE8-rot-in 264.48 APE67-dihe-in -59.64, -26.2 -50.08, -49.71 APE12-dist-in 13.488 APE11-dist-in 11.764 APE10-dist-in 7.955 APE9-dist-in 3.231 None PTR321 PTR321 XRAY 2.7 0.228 0.252 D 382 343 4 0 0 0 [[159, 479]] 1.0 5aik Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A4WA Q13627 136 481 763.0 QYH:501 Type1 Active DFGin 7.514 14.841 BLAminus -120.3, 168.53 72.59, 81.22 -96.63, 23.6 288.31, 80.09 -71.01, -22.42 in-in in 8.491 Saltbr-in 2.835 HRD-in -59.72, -50.21 79.8, 0.59 in-in-in SNCiii in-in ActLoopNT-in 3.003 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.05, 174.06 APE9-dihe-na 68.15, 147.74 APE8-dihe-in -68.98, 144.2 APE8-rot-in 298.89 APE67-dihe-in -63.8, -25.02 -56.72, -43.13 APE12-dist-in 9.924 APE11-dist-in 12.077 APE10-dist-in 7.536 APE9-dist-in 3.227 None PTR321 PTR321 XRAY 2.7 0.165 0.205 A 382 340 6 0 0 0 [[159, 479]] 1.0 7a4w Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A55A Q13627 136 481 763.0 QZ2:501 Type1 Active DFGin 7.451 14.684 BLAminus -119.66, 171.79 70.04, 73.01 -89.35, 24.06 289.05, 80.07 -69.14, -22.64 in-in in 8.713 Saltbr-in 2.75 HRD-in -60.62, -50.43 82.56, -1.02 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.49, 170.31 APE9-dihe-na 73.06, 145.82 APE8-dihe-in -70.98, 140.61 APE8-rot-in 304.48 APE67-dihe-in -64.49, -24.47 -51.36, -43.54 APE12-dist-in 10.05 APE11-dist-in 12.225 APE10-dist-in 7.691 APE9-dist-in 3.217 None PTR321 PTR321 XRAY 2.2 0.182 0.225 A 382 340 6 0 0 0 [[159, 479]] 1.0 7a55 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A5BA Q13627 136 481 763.0 MFR:501 Type1 Active DFGin 7.453 14.846 BLAminus -123.33, 168.55 72.72, 88.97 -105.77, 23.56 281.26, 83.72 -72.41, -22.85 in-in in 8.485 Saltbr-in 2.953 HRD-in -66.22, -48.04 76.25, -4.46 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.35, 172.6 APE9-dihe-na 68.45, 154.81 APE8-dihe-in -72.07, 143.61 APE8-rot-in 303.66 APE67-dihe-in -68.11, -19.27 -52.63, -42.7 APE12-dist-in 9.784 APE11-dist-in 11.923 APE10-dist-in 7.448 APE9-dist-in 3.103 None PTR321 PTR321 XRAY 2.6 0.155 0.192 A 382 340 6 0 0 0 [[159, 479]] 1.0 7a5b Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7ZH8A Q13627 135 482 763.0 IWU:501,IWU:503 Type1,Allosteric Active DFGin 6.93 14.485 BLAminus -122.84, 179.43 62.46, 67.96 -84.46, 26.09 290.83, 71.55 -67.12, -11.2 in-in in 8.883 Saltbr-in 2.724 HRD-in -63.87, -44.79 74.86, -8.37 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.43, 165.77 APE9-dihe-na 78.45, 153.82 APE8-dihe-in -75.88, 144.9 APE8-rot-in 282.17 APE67-dihe-in -60.66, -29.31 -54.53, -47.47 APE12-dist-in 12.842 APE11-dist-in 11.113 APE10-dist-in 7.113 APE9-dist-in 3.047 None PTR321 PTR321 XRAY 2.3 0.199 0.235 A 382 348 0 0 0 0 [[159, 479]] 1.0 7zh8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7ZH8B Q13627 135 481 763.0 IWU:501,IWU:502 Type1,Allosteric Active DFGin 7.016 14.696 BLAminus -126.24, 176.32 61.01, 72.92 -85.71, 26.03 289.71, 74.68 -65.98, -19.69 in-in in 8.922 Saltbr-in 2.551 HRD-in -62.74, -46.92 79.26, -5.01 in-in-in SNCiii in-in ActLoopNT-in 2.776 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.66, 167.11 APE9-dihe-na 77.27, 157.6 APE8-dihe-in -78.84, 143.58 APE8-rot-in 289.38 APE67-dihe-in -64.23, -22.19 -57.38, -41.71 APE12-dist-in 12.706 APE11-dist-in 11.378 APE10-dist-in 7.012 APE9-dist-in 3.066 None PTR321 PTR321 XRAY 2.3 0.199 0.235 B 382 347 0 0 0 0 [[159, 479]] 1.0 7zh8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7ZH8C Q13627 136 481 763.0 IWU:502,IWU:504 Type1,Allosteric Active DFGin 6.95 14.526 BLAminus -134.74, -179.56 61.5, 68.92 -87.34, 24.99 287.1, 79.14 -63.98, -23.48 in-in in 8.908 Saltbr-in 2.284 HRD-in -62.72, -47.25 75.43, -4.98 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.64, 173.03 APE9-dihe-na 68.29, 149.69 APE8-dihe-in -67.12, 144.66 APE8-rot-in 287.21 APE67-dihe-in -61.1, -29.22 -57.48, -42.67 APE12-dist-in 12.923 APE11-dist-in 11.192 APE10-dist-in 6.996 APE9-dist-in 3.16 None PTR321 PTR321 XRAY 2.3 0.199 0.235 C 382 346 0 0 0 0 [[159, 479]] 1.0 7zh8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7ZH8D Q13627 135 480 763.0 IWU:501,IWU:502 Type1,Allosteric Active DFGin 6.962 14.615 BLAminus -123.17, -177.61 59.0, 69.45 -88.29, 28.99 287.8, 74.48 -73.6, -11.3 in-in in 8.821 Saltbr-in 2.61 HRD-in -61.94, -44.56 72.7, -0.97 in-in-in SNCiii in-in ActLoopNT-in 2.549 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.11, 172.59 APE9-dihe-na 67.75, 147.93 APE8-dihe-in -73.89, 139.89 APE8-rot-in 260.52 APE67-dihe-in -46.52, -33.56 -54.25, -52.57 APE12-dist-in 12.275 APE11-dist-in 11.283 APE10-dist-in 6.938 APE9-dist-in 3.153 None PTR321 PTR321 XRAY 2.3 0.199 0.235 D 382 346 0 0 0 0 [[159, 479]] 1.0 7zh8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8C3QA Q13627 134 480 763.0 RUT:501 Type1.5_Back Active DFGin 7.532 14.605 BLAminus -124.23, 179.11 72.21, 75.86 -95.78, 26.15 290.44, 76.76 -62.33, -27.15 in-in in 9.176 Saltbr-in 3.215 HRD-in -66.45, -50.9 75.85, 5.78 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.82, 171.3 APE9-dihe-na 70.78, 147.49 APE8-dihe-in -69.41, 147.33 APE8-rot-in 280.79 APE67-dihe-in -56.28, -27.14 -64.52, -44.2 APE12-dist-in 12.096 APE11-dist-in 10.7 APE10-dist-in 6.537 APE9-dist-in 3.086 None PTR321 PTR321 XRAY 2.32 0.178 0.21 A 370 344 3 0 0 0 [[159, 479]] 1.0 8c3q Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8C3QB Q13627 136 480 763.0 RUT:501 Type1.5_Back Active DFGin 7.376 14.823 BLAminus -127.14, 177.53 66.16, 80.91 -99.41, 25.8 287.74, 74.6 -66.59, -26.2 in-in in 9.106 Saltbr-in 3.03 HRD-in -69.45, -45.26 72.64, 7.14 in-in-in SNCiii in-in ActLoopNT-in 2.692 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.34, 175.86 APE9-dihe-na 74.43, 169.23 APE8-dihe-in -95.61, 134.32 APE8-rot-in 284.11 APE67-dihe-in -56.76, -28.89 -40.65, -51.81 APE12-dist-in 12.117 APE11-dist-in 10.746 APE10-dist-in 6.799 APE9-dist-in 3.089 None PTR321 PTR321 XRAY 2.32 0.178 0.21 B 370 344 1 0 0 0 [[159, 479]] 1.0 8c3q Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6UIPB Q13627 136 478 763.0 Q8J:501 Type1 Inactive DFGin 6.895 14.93 ABAminus -128.46, -42.33 -94.91, 127.61 -132.24, 12.58 285.14, 81.63 -56.41, -45.59 in-in in 9.087 Saltbr-in 2.898 HRD-in -67.7, -47.87 68.18, -0.51 in-in-in SNCiii in-in ActLoopNT-in 3.091 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.31, 177.75 APE9-dihe-na 64.01, 150.34 APE8-dihe-in -71.42, 137.1 APE8-rot-in 300.33 APE67-dihe-in -57.48, -29.96 -50.84, -45.43 APE12-dist-in 12.84 APE11-dist-in 11.176 APE10-dist-in 7.15 APE9-dist-in 2.974 None PTR321 PTR321 XRAY 3.7 0.272 0.29 B 361 338 6 0 0 0 [[159, 479]] 1.0 6uip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6UIPC Q13627 131 477 763.0 Q8J:501 Type1 Inactive DFGin 6.957 14.584 ABAminus -128.48, -41.69 -94.89, 138.63 -139.05, 93.64 283.54, 77.23 -157.81, 999.0 in-in in 8.695 Saltbr-in 2.66 HRD-in -68.31, -47.09 68.76, -0.11 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na -122.81, -42.23 APE9-dihe-na -85.49, 157.66 APE8-dihe-in -67.92, 135.09 APE8-rot-out 172.73 APE67-dihe-in -59.1, -31.97 -53.15, -45.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.046 None PTR321 PTR321 XRAY 3.7 0.272 0.29 C 361 306 39 0 0 9 [[159, 479]] 1.0 6uip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A4OB Q13627 134 481 763.0 ANP:501 ATPlike Inactive DFGin 7.223 15.047 BLAminus -127.4, 170.29 72.8, 80.08 -93.18, 24.5 286.73, 76.67 -71.46, -26.03 in-in in 8.365 Saltbr-in 2.797 HRD-in -57.9, -49.71 71.19, 2.83 in-in-out SNCiio in-out ActLoopNT-in 2.84 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -84.65, 164.16 APE9-dihe-na 75.07, 150.77 APE8-dihe-in -68.35, 138.34 APE8-rot-in 298.16 APE67-dihe-in -63.89, -24.74 -46.52, -48.39 APE12-dist-out 14.097 APE11-dist-in 11.896 APE10-dist-in 7.537 APE9-dist-in 3.028 None PTR321 PTR321 XRAY 1.9 0.18 0.203 B 382 341 7 0 0 0 [[159, 479]] 1.0 7a4o Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EILC Q13627 135 479 763.0 No_ligand No_ligand Inactive DFGin 7.37 15.158 BLAminus -131.05, 169.12 64.27, 85.03 -103.64, 28.05 281.44, 77.48 -71.23, -40.12 in-in in 8.643 Saltbr-in 2.937 HRD-in -68.33, -38.56 64.92, 12.92 in-in-out SNCiio in-out ActLoopNT-in 2.888 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -130.34, 174.88 APE9-dihe-na 62.38, 154.4 APE8-dihe-in -77.48, 142.58 APE8-rot-in 292.83 APE67-dihe-in -52.78, -22.59 -54.68, -54.7 APE12-dist-out 14.139 APE11-dist-in 11.754 APE10-dist-out 8.119 APE9-dist-in 3.283 None PTR321 PTR321 XRAY 2.465 0.213 0.254 C 368 333 12 0 0 0 [[159, 479]] 1.0 6eil Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A52A Q13627 148 479 763.0 QYB:60501 Type1 Inactive DFGin 7.317 14.879 BLAminus -123.16, 170.09 65.81, 84.07 -98.75, 23.74 289.83, 75.25 -64.25, -28.4 in-in in 8.518 Saltbr-in 2.706 HRD-in -61.91, -47.73 72.05, 4.02 in-in-out SNCiio in-out ActLoopNT-in 2.84 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.5, 160.85 APE9-dihe-na 74.97, 147.38 APE8-dihe-in -70.98, 136.41 APE8-rot-out 187.37 APE67-dihe-in -56.3, -29.72 -45.33, -55.66 APE12-dist-in 12.302 APE11-dist-in 10.999 APE10-dist-in 7.285 APE9-dist-in 3.099 None PTR321 PTR321 XRAY 2.1 0.167 0.206 A 355 329 3 0 0 0 [[159, 479]] 1.0 7a52 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 7.9e-91 310.3 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7OY6C Q13627 135 481 763.0 39I:501 Type1 Inactive DFGin 7.648 15.4 BLAminus -125.83, 168.21 66.48, 82.31 -94.71, 17.96 280.2, 86.53 -72.92, -24.78 in-in in 8.812 Saltbr-in 3.231 HRD-in -68.26, -38.56 68.22, 7.69 in-in-out SNCiio in-out ActLoopNT-in 2.664 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -109.61, 169.12 APE9-dihe-na 78.1, 158.02 APE8-dihe-in -72.9, 138.3 APE8-rot-out 215.64 APE67-dihe-in -58.63, -31.51 -47.01, -53.58 APE12-dist-out 14.468 APE11-dist-in 12.493 APE10-dist-out 8.058 APE9-dist-in 3.359 None PTR321 PTR321 XRAY 2.38 0.202 0.27 C 359 343 4 0 0 0 [[159, 479]] 1.0 7oy6 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJVA Q13627 148 481 763.0 RKK:60501 Type1 Inactive DFGin 7.083 14.724 BLAminus -123.61, 170.03 70.85, 87.15 -98.76, 25.47 292.1, 75.69 -58.41, -34.3 in-in in 8.669 Saltbr-in 2.489 HRD-in -60.17, -50.82 77.68, 3.17 in-in-out SNCiio in-out ActLoopNT-in 2.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.87, 159.47 APE9-dihe-na 70.75, 141.67 APE8-dihe-in -65.64, 133.79 APE8-rot-out 171.55 APE67-dihe-in -58.95, -30.68 -50.41, -48.06 APE12-dist-in 11.625 APE11-dist-in 10.455 APE10-dist-in 6.904 APE9-dist-in 3.063 None PTR321 PTR321 XRAY 2.1 0.182 0.219 A 359 330 4 0 0 0 [[159, 479]] 1.0 7ajv Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJVB Q13627 148 481 763.0 RKK:60501 Type1 Inactive DFGin 7.184 14.628 BLAminus -117.14, 169.86 69.68, 90.8 -103.92, 27.7 282.23, 78.07 -72.14, -22.36 in-in in 8.618 Saltbr-in 2.757 HRD-in -62.69, -52.71 75.84, 3.99 in-in-out SNCiio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -148.21, 169.45 APE9-dihe-na 77.96, 139.9 APE8-dihe-in -73.65, 144.05 APE8-rot-out 83.51 APE67-dihe-in -59.27, -27.74 -53.72, -47.01 APE12-dist-in 12.782 APE11-dist-in 10.832 APE10-dist-in 6.539 APE9-dist-in 3.096 None PTR321 PTR321 XRAY 2.1 0.182 0.219 B 359 327 7 0 0 0 [[159, 479]] 1.0 7ajv Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJYA Q13627 148 481 763.0 RKZ:60501 Type1 Inactive DFGin 7.153 14.575 BLAminus -120.41, 167.48 78.93, 86.44 -103.86, 24.23 289.2, 84.36 -65.73, -34.02 in-in in 8.58 Saltbr-in 2.68 HRD-in -65.87, -47.05 67.93, 7.7 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.54, 163.03 APE9-dihe-na 66.78, 135.8 APE8-dihe-in -55.89, 133.22 APE8-rot-out 187.97 APE67-dihe-in -62.45, -26.31 -51.83, -46.65 APE12-dist-in 11.587 APE11-dist-in 10.706 APE10-dist-in 7.145 APE9-dist-in 3.166 None PTR321 PTR321 XRAY 2.2 0.185 0.225 A 359 330 4 0 0 0 [[159, 479]] 1.0 7ajy Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AJYB Q13627 148 481 763.0 RKZ:60501 Type1 Inactive DFGin 7.296 14.556 BLAminus -121.44, 168.83 70.7, 88.53 -103.39, 25.09 284.65, 82.01 -78.66, -10.84 in-in in 8.732 Saltbr-in 2.67 HRD-in -63.4, -50.81 70.51, 11.76 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -148.9, 170.84 APE9-dihe-na 74.85, 141.66 APE8-dihe-in -63.58, 131.13 APE8-rot-out 201.85 APE67-dihe-in -63.09, -26.02 -42.21, -47.55 APE12-dist-in 12.959 APE11-dist-in 11.061 APE10-dist-in 6.961 APE9-dist-in 3.372 None PTR321 PTR321 XRAY 2.2 0.185 0.225 B 359 323 11 0 0 0 [[159, 479]] 1.0 7ajy Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AK2A Q13627 148 481 763.0 RHH:60501 Type1 Inactive DFGin 7.291 14.851 BLAminus -115.74, 169.98 74.14, 90.39 -102.75, 24.02 288.48, 76.67 -68.21, -33.16 in-in in 8.772 Saltbr-in 2.761 HRD-in -65.68, -50.14 75.59, 4.1 in-in-out SNCiio in-out ActLoopNT-in 2.874 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.73, 160.37 APE9-dihe-na 71.52, 143.92 APE8-dihe-in -64.68, 134.05 APE8-rot-out 173.39 APE67-dihe-in -55.51, -27.41 -48.64, -56.18 APE12-dist-in 11.739 APE11-dist-in 10.424 APE10-dist-in 6.918 APE9-dist-in 3.112 None PTR321 PTR321 XRAY 2.1 0.198 0.231 A 359 331 3 0 0 0 [[159, 479]] 1.0 7ak2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AK2B Q13627 148 481 763.0 RHH:60501 Type1 Inactive DFGin 7.283 14.688 BLAminus -117.62, 169.19 72.17, 91.09 -105.5, 27.65 285.34, 74.8 -80.26, -16.76 in-in in 8.738 Saltbr-in 2.729 HRD-in -64.18, -49.57 76.66, 4.04 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.09, 173.48 APE9-dihe-na 74.34, 146.62 APE8-dihe-in -67.4, 134.77 APE8-rot-out 184.21 APE67-dihe-in -56.53, -28.03 -46.83, -54.27 APE12-dist-in 12.704 APE11-dist-in 11.103 APE10-dist-in 6.668 APE9-dist-in 3.152 None PTR321 PTR321 XRAY 2.1 0.198 0.231 B 359 327 7 0 0 0 [[159, 479]] 1.0 7ak2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AKAA Q13627 148 481 763.0 RK2:60501 Type1 Inactive DFGin 7.121 14.683 BLAminus -118.64, 167.89 71.85, 90.88 -104.61, 26.29 284.62, 77.32 -66.04, -26.17 in-in in 8.674 Saltbr-in 2.718 HRD-in -64.96, -49.4 75.94, 3.16 in-in-out SNCiio in-out ActLoopNT-in 2.783 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -148.73, 171.65 APE9-dihe-na 73.64, 144.05 APE8-dihe-in -67.38, 137.53 APE8-rot-out 177.41 APE67-dihe-in -59.7, -26.08 -53.2, -48.16 APE12-dist-in 12.846 APE11-dist-in 11.047 APE10-dist-in 6.727 APE9-dist-in 3.203 None PTR321 PTR321 XRAY 1.9 0.174 0.211 A 359 327 7 0 0 0 [[159, 479]] 1.0 7aka Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AKAB Q13627 148 481 763.0 RK2:60501 Type1 Inactive DFGin 7.167 14.793 BLAminus -121.95, 166.05 77.1, 90.48 -104.52, 21.8 284.24, 85.51 -65.0, -33.17 in-in in 8.634 Saltbr-in 2.65 HRD-in -66.63, -48.77 76.89, 1.39 in-in-out SNCiio in-out ActLoopNT-in 2.918 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.86, 162.5 APE9-dihe-na 69.1, 142.46 APE8-dihe-in -64.79, 134.35 APE8-rot-out 179.34 APE67-dihe-in -57.61, -31.09 -48.59, -49.25 APE12-dist-in 11.967 APE11-dist-in 10.697 APE10-dist-in 6.986 APE9-dist-in 3.067 None PTR321 PTR321 XRAY 1.9 0.174 0.211 B 359 330 4 0 0 0 [[159, 479]] 1.0 7aka Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AKBA Q13627 148 481 763.0 RJZ:60501 Type1 Inactive DFGin 7.213 14.196 BLAminus -124.09, -178.78 64.16, 81.03 -98.47, 34.82 287.29, 82.14 -91.53, -10.23 in-in in 8.413 Saltbr-in 2.371 HRD-in -60.25, -38.91 64.29, 1.37 in-in-out SNCiio in-out ActLoopNT-in 2.689 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.85, 174.48 APE9-dihe-na 78.85, 161.11 APE8-dihe-in -81.8, 138.37 APE8-rot-out 193.17 APE67-dihe-in -52.47, -29.53 -48.51, -57.21 APE12-dist-in 12.559 APE11-dist-in 10.708 APE10-dist-in 6.026 APE9-dist-in 2.937 None PTR321 PTR321 XRAY 2.8 0.197 0.248 A 359 327 7 0 0 0 [[159, 479]] 1.0 7akb Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AKBB Q13627 148 481 763.0 RJZ:60501 Type1 Inactive DFGin 7.114 14.481 BLAminus -126.85, -177.09 63.55, 78.5 -99.69, 38.47 289.46, 82.22 -88.73, -23.7 in-in in 8.506 Saltbr-in 2.46 HRD-in -57.16, -39.4 67.41, 4.61 in-in-out SNCiio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.81, 161.1 APE9-dihe-na 75.42, 163.85 APE8-dihe-in -80.4, 143.9 APE8-rot-out 185.64 APE67-dihe-in -56.87, -37.37 -45.64, -60.47 APE12-dist-in 11.599 APE11-dist-in 10.648 APE10-dist-in 6.659 APE9-dist-in 2.962 None PTR321 PTR321 XRAY 2.8 0.197 0.248 B 359 329 5 0 0 0 [[159, 479]] 1.0 7akb Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AKEA Q13627 148 481 763.0 RK8:60501 Type1 Inactive DFGin 6.963 14.696 BLAminus -124.29, 171.29 66.05, 88.52 -103.72, 32.03 286.65, 86.84 -69.65, -28.4 in-in in 8.657 Saltbr-in 2.74 HRD-in -55.46, -52.04 76.49, -6.74 in-in-out SNCiio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.97, 172.85 APE9-dihe-na 70.76, 139.43 APE8-dihe-in -62.48, 134.14 APE8-rot-out 223.94 APE67-dihe-in -56.1, -32.56 -47.63, -48.41 APE12-dist-in 12.591 APE11-dist-in 10.85 APE10-dist-in 6.827 APE9-dist-in 3.233 None PTR321 PTR321 XRAY 2.3 0.23 0.284 A 359 326 8 0 0 0 [[159, 479]] 1.0 7ake Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7AKEB Q13627 148 481 763.0 RK8:60501 Type1 Inactive DFGin 6.962 14.536 BLAminus -123.67, 174.51 70.81, 90.54 -105.83, 23.0 281.74, 93.32 -67.08, -29.7 in-in in 8.426 Saltbr-in 2.881 HRD-in -57.75, -50.61 73.65, -0.98 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.84, 158.68 APE9-dihe-na 73.04, 138.35 APE8-dihe-in -54.72, 130.03 APE8-rot-out 183.62 APE67-dihe-in -61.07, -29.87 -52.21, -41.09 APE12-dist-in 11.72 APE11-dist-in 10.621 APE10-dist-in 6.908 APE9-dist-in 2.993 None PTR321 PTR321 XRAY 2.3 0.23 0.284 B 359 329 5 0 0 0 [[159, 479]] 1.0 7ake Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.2e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4MQ2D Q13627 135 480 763.0 2C4:501 Type1 Inactive DFGin 7.123 14.677 BLAminus -125.93, 172.67 67.54, 75.32 -95.86, 30.17 291.65, 80.25 -78.68, -5.86 in-in in 8.779 Saltbr-in 2.752 HRD-in -62.52, -51.42 84.63, -0.78 in-in-out SNCiio in-out ActLoopNT-in 2.702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.81, 169.31 APE9-dihe-na 78.64, 158.51 APE8-dihe-in -88.72, 136.22 APE8-rot-out 152.13 APE67-dihe-in -61.7, -23.39 -43.42, -54.44 APE12-dist-in 13.722 APE11-dist-in 11.548 APE10-dist-in 7.582 APE9-dist-in 2.926 None PTR321 PTR321 XRAY 2.8 0.193 0.258 D 361 330 16 0 0 0 [[159, 479]] 1.0 4mq2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 8R8EA Q13627 135 481 763.0 YOX:501 Type1 Inactive DFGin 7.024 14.505 BLAminus -129.01, 171.95 62.59, 74.26 -89.71, 28.71 287.29, 75.01 -75.72, -10.22 in-in in 8.616 Saltbr-in 2.892 HRD-in -63.02, -47.54 76.3, -2.75 in-in-out SNCiio in-out ActLoopNT-in 2.91 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.31, 169.2 APE9-dihe-na 75.21, 146.05 APE8-dihe-in -69.06, 139.75 APE8-rot-out 193.55 APE67-dihe-in -59.48, -26.23 -55.55, -45.75 APE12-dist-in 12.641 APE11-dist-in 11.084 APE10-dist-in 6.734 APE9-dist-in 3.115 None PTR321 PTR321 XRAY 2.22 0.2 0.234 A 361 347 0 0 0 0 [[159, 479]] 1.0 8r8e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7FHSA Q13627 134 481 763.0 4VZ:501 Type1 Inactive DFGin 7.241 14.926 BLAminus -121.39, 176.07 62.5, 85.89 -99.63, 18.4 279.74, 77.39 -67.82, -18.09 in-in in 8.534 Saltbr-in 2.505 HRD-in -59.16, -48.2 82.44, -2.99 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -129.74, 161.14 APE9-dihe-na 76.96, 152.88 APE8-dihe-in -66.51, 139.46 APE8-rot-in 276.14 APE67-dihe-in -65.33, -20.38 -53.89, -45.41 APE12-dist-out 14.124 APE11-dist-in 12.105 APE10-dist-out 8.132 APE9-dist-in 3.11 None PTR321 PTR321 XRAY 2.42 0.234 0.275 A 361 343 5 0 0 0 [[159, 479]] 1.0 7fhs Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7FHSC Q13627 134 480 763.0 4VZ:501 Type1 Inactive DFGin 7.147 14.803 BLAminus -122.76, 175.78 63.26, 85.37 -100.76, 19.54 285.72, 82.11 -73.67, -2.97 in-in in 8.844 Saltbr-in 2.717 HRD-in -56.19, -50.9 88.82, -2.51 in-in-out SNCiio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -138.77, 162.39 APE9-dihe-na 77.37, 153.1 APE8-dihe-in -64.98, 135.39 APE8-rot-in 268.68 APE67-dihe-in -55.6, -25.7 -46.74, -55.19 APE12-dist-in 13.909 APE11-dist-in 11.996 APE10-dist-out 8.024 APE9-dist-in 3.256 None PTR321 PTR321 XRAY 2.42 0.234 0.275 C 361 341 6 0 0 0 [[159, 479]] 1.0 7fhs Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7FHSD Q13627 134 480 763.0 4VZ:501 Type1 Inactive DFGin 7.411 15.065 BLAminus -127.1, 176.87 62.95, 73.78 -97.03, 21.7 278.97, 80.32 -71.98, -32.85 in-in in 8.797 Saltbr-in 2.973 HRD-in -62.79, -46.25 79.63, -0.41 in-in-out SNCiio in-out ActLoopNT-in 2.734 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -142.76, 171.2 APE9-dihe-na 70.9, 168.34 APE8-dihe-in -89.11, 136.94 APE8-rot-in 273.67 APE67-dihe-in -56.34, -27.28 -43.9, -54.58 APE12-dist-out 14.334 APE11-dist-in 11.899 APE10-dist-out 8.219 APE9-dist-in 3.105 None PTR321 PTR321 XRAY 2.42 0.234 0.275 D 361 342 5 0 0 0 [[159, 479]] 1.0 7fhs Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7FHTA Q13627 134 481 763.0 4WD:501 Type1 Inactive DFGin 7.385 15.04 BLAminus -115.56, 172.1 66.07, 83.84 -100.52, 20.7 283.28, 78.58 -68.54, -23.03 in-in in 8.7 Saltbr-in 3.285 HRD-in -57.68, -43.02 74.5, -0.17 in-in-out SNCiio in-out ActLoopNT-in 2.768 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -135.55, 163.58 APE9-dihe-na 69.38, 153.5 APE8-dihe-in -68.25, 140.14 APE8-rot-in 282.31 APE67-dihe-in -63.83, -23.96 -47.13, -50.62 APE12-dist-in 13.845 APE11-dist-in 12.051 APE10-dist-out 8.165 APE9-dist-in 3.074 None PTR321 PTR321 XRAY 2.68 0.191 0.249 A 361 343 5 0 0 0 [[159, 479]] 1.0 7fht Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7FHTB Q13627 134 480 763.0 4WD:501 Type1 Inactive DFGin 7.552 14.875 BLAminus -130.16, 173.47 60.71, 76.23 -98.42, 21.02 279.61, 81.43 -74.75, -28.83 in-in in 8.627 Saltbr-in 2.693 HRD-in -57.11, -44.93 77.29, 4.6 in-in-out SNCiio in-out ActLoopNT-in 2.833 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -136.63, 166.07 APE9-dihe-na 72.34, 153.51 APE8-dihe-in -70.32, 130.86 APE8-rot-in 279.96 APE67-dihe-in -61.47, -23.44 -50.08, -46.31 APE12-dist-in 13.847 APE11-dist-in 11.829 APE10-dist-out 8.0 APE9-dist-in 3.279 None PTR321 PTR321 XRAY 2.68 0.191 0.249 B 361 341 6 0 0 0 [[159, 479]] 1.0 7fht Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7FHTC Q13627 134 480 763.0 4WD:501 Type1 Inactive DFGin 7.372 15.027 BLAminus -125.03, 174.37 63.18, 83.49 -99.9, 20.78 282.36, 79.78 -79.83, -7.76 in-in in 8.723 Saltbr-in 3.03 HRD-in -55.31, -47.7 76.16, 8.53 in-in-out SNCiio in-out ActLoopNT-in 3.021 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -126.03, 164.79 APE9-dihe-na 71.34, 164.59 APE8-dihe-in -70.74, 135.69 APE8-rot-in 297.13 APE67-dihe-in -61.65, -39.99 -48.8, -48.72 APE12-dist-out 14.132 APE11-dist-in 11.947 APE10-dist-out 8.075 APE9-dist-in 3.185 None PTR321 PTR321 XRAY 2.68 0.191 0.249 C 361 341 6 0 0 0 [[159, 479]] 1.0 7fht Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7FHTD Q13627 134 480 763.0 4WD:501 Type1 Inactive DFGin 7.413 15.13 BLAminus -127.5, 171.04 65.84, 77.76 -97.3, 15.13 281.72, 82.6 -61.5, -43.31 in-in in 8.663 Saltbr-in 2.595 HRD-in -56.98, -47.37 76.71, 7.39 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -125.8, 168.64 APE9-dihe-na 68.47, 157.81 APE8-dihe-in -75.05, 138.24 APE8-rot-in 287.07 APE67-dihe-in -63.35, -29.18 -50.59, -48.07 APE12-dist-out 14.251 APE11-dist-in 12.098 APE10-dist-out 8.34 APE9-dist-in 3.344 None PTR321 PTR321 XRAY 2.68 0.191 0.249 D 361 342 5 0 0 0 [[159, 479]] 1.0 7fht Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 3ANQA Q13627 134 481 763.0 EHB:1 Type1 Inactive DFGin 7.428 15.033 BLAminus -121.67, -179.92 58.78, 88.75 -108.07, 22.93 278.63, 78.12 -73.99, -18.87 in-in in 8.689 Saltbr-in 2.68 HRD-in -53.82, -46.32 72.12, 1.71 in-in-out SNCiio in-out ActLoopNT-in 2.676 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -134.05, 156.97 APE9-dihe-na 80.08, 156.96 APE8-dihe-in -74.85, 138.03 APE8-rot-in 277.08 APE67-dihe-in -54.91, -29.37 -41.62, -56.78 APE12-dist-in 13.847 APE11-dist-in 11.843 APE10-dist-out 8.098 APE9-dist-in 3.321 None PTR321 PTR321 XRAY 2.6 0.236 0.27 A 368 343 5 0 0 0 [[159, 479]] 1.0 3anq Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 3ANQB Q13627 133 481 763.0 EHB:1 Type1 Inactive DFGin 7.435 15.059 BLAminus -120.5, 177.48 60.82, 88.34 -107.39, 25.34 279.32, 79.44 -76.35, -18.64 in-in in 8.777 Saltbr-in 2.628 HRD-in -52.09, -40.38 68.1, -0.17 in-in-out SNCiio in-out ActLoopNT-in 3.565 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -110.82, 170.49 APE9-dihe-na 72.23, 154.86 APE8-dihe-in -73.28, 139.58 APE8-rot-in 273.53 APE67-dihe-in -54.53, -27.07 -43.45, -57.9 APE12-dist-out 14.259 APE11-dist-in 12.132 APE10-dist-out 8.046 APE9-dist-in 3.354 None PTR321 PTR321 XRAY 2.6 0.236 0.27 B 368 344 5 0 0 0 [[159, 479]] 1.0 3anq Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 3ANQC Q13627 134 481 763.0 EHB:1 Type1 Inactive DFGin 7.463 15.221 BLAminus -119.05, 176.81 62.43, 87.36 -107.94, 27.53 279.33, 76.42 -77.11, -19.63 in-in in 8.714 Saltbr-in 2.613 HRD-in -51.7, -39.15 66.16, -1.22 in-in-out SNCiio in-out ActLoopNT-in 3.544 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -111.74, 164.15 APE9-dihe-na 79.15, 156.09 APE8-dihe-in -74.1, 139.85 APE8-rot-in 275.2 APE67-dihe-in -53.52, -28.49 -43.27, -57.57 APE12-dist-in 13.925 APE11-dist-in 12.218 APE10-dist-out 8.167 APE9-dist-in 3.38 None PTR321 PTR321 XRAY 2.6 0.236 0.27 C 368 341 7 0 0 0 [[159, 479]] 1.0 3anq Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 3ANQD Q13627 136 479 763.0 EHB:1 Type1 Inactive DFGin 7.594 15.139 BLAminus -117.59, 176.99 61.44, 86.46 -106.43, 25.3 279.19, 78.64 -77.29, -17.82 in-in in 8.733 Saltbr-in 2.587 HRD-in -55.98, -44.97 70.33, -1.13 in-in-out SNCiio in-out ActLoopNT-in 3.321 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -131.55, 165.5 APE9-dihe-na 73.05, 156.06 APE8-dihe-in -74.09, 138.2 APE8-rot-in 274.37 APE67-dihe-in -57.04, -27.51 -41.5, -55.11 APE12-dist-in 13.917 APE11-dist-in 12.097 APE10-dist-out 8.168 APE9-dist-in 3.283 None PTR321 PTR321 XRAY 2.6 0.236 0.27 D 368 335 9 0 0 0 [[159, 479]] 1.0 3anq Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 3ANRB Q13627 133 481 763.0 HRM:1 Type1 Inactive DFGin 7.455 14.931 BLAminus -127.37, 175.29 64.18, 86.03 -102.43, 22.55 283.14, 80.72 -64.64, -20.73 in-in in 8.733 Saltbr-in 2.866 HRD-in -58.01, -41.76 68.55, -4.63 in-in-out SNCiio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -113.3, 162.51 APE9-dihe-na 75.38, 151.66 APE8-dihe-in -71.98, 142.21 APE8-rot-in 293.97 APE67-dihe-in -54.5, -26.35 -45.44, -54.76 APE12-dist-in 13.749 APE11-dist-in 11.894 APE10-dist-out 8.014 APE9-dist-in 3.315 None PTR321 PTR321 XRAY 2.6 0.232 0.264 B 368 343 6 0 0 0 [[159, 479]] 1.0 3anr Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 3ANRC Q13627 134 481 763.0 HRM:1 Type1 Inactive DFGin 7.352 14.825 BLAminus -127.39, 175.73 63.91, 86.99 -105.92, 24.64 282.96, 79.27 -68.52, -18.05 in-in in 8.72 Saltbr-in 2.964 HRD-in -60.25, -41.86 68.21, -2.43 in-in-out SNCiio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -115.38, 158.82 APE9-dihe-na 80.57, 155.21 APE8-dihe-in -73.66, 142.81 APE8-rot-in 291.66 APE67-dihe-in -55.43, -28.06 -45.81, -53.64 APE12-dist-out 14.213 APE11-dist-in 12.115 APE10-dist-out 8.258 APE9-dist-in 3.335 None PTR321 PTR321 XRAY 2.6 0.232 0.264 C 368 338 10 0 0 0 [[159, 479]] 1.0 3anr Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 3ANRD Q13627 134 479 763.0 HRM:1 Type1 Inactive DFGin 7.439 14.887 BLAminus -126.79, 174.71 64.81, 86.52 -103.95, 22.81 283.21, 80.12 -67.2, -17.95 in-in in 8.734 Saltbr-in 2.974 HRD-in -61.66, -39.95 66.39, -3.38 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -134.79, 162.98 APE9-dihe-na 75.68, 154.5 APE8-dihe-in -74.59, 142.8 APE8-rot-in 292.67 APE67-dihe-in -57.39, -25.31 -44.77, -54.21 APE12-dist-out 14.035 APE11-dist-in 12.145 APE10-dist-out 8.165 APE9-dist-in 3.245 None PTR321 PTR321 XRAY 2.6 0.232 0.264 D 368 341 5 0 0 0 [[159, 479]] 1.0 3anr Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4NCTA Q13627 134 480 763.0 2K2:501 Type1 Inactive DFGin 7.45 15.223 BLAminus -119.55, 166.32 66.7, 85.69 -102.67, 26.83 290.37, 74.07 -64.21, -35.16 in-in in 8.649 Saltbr-in 2.708 HRD-in -61.53, -41.99 82.27, -8.19 in-in-out SNCiio in-out ActLoopNT-in 3.351 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -139.9, 164.55 APE9-dihe-na 71.96, 159.44 APE8-dihe-in -83.39, 140.05 APE8-rot-in 288.68 APE67-dihe-in -54.11, -34.74 -49.22, -50.15 APE12-dist-out 14.148 APE11-dist-in 11.947 APE10-dist-out 8.466 APE9-dist-in 3.233 None PTR321 PTR321 XRAY 2.597 0.21 0.249 A 368 342 5 0 0 0 [[159, 479]] 1.0 4nct Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4NCTB Q13627 133 480 763.0 2K2:501 Type1 Inactive DFGin 7.537 15.483 BLAminus -112.81, 170.12 65.22, 81.69 -98.56, 30.84 285.57, 81.33 -75.02, -33.69 in-in in 8.788 Saltbr-in 2.746 HRD-in -63.66, -42.9 78.55, 1.57 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -129.36, 161.46 APE9-dihe-na 75.46, 146.38 APE8-dihe-in -68.35, 143.08 APE8-rot-in 284.05 APE67-dihe-in -64.51, -32.58 -57.82, -38.26 APE12-dist-out 14.378 APE11-dist-in 12.147 APE10-dist-out 8.615 APE9-dist-in 3.255 None PTR321 PTR321 XRAY 2.597 0.21 0.249 B 368 334 14 0 0 0 [[159, 479]] 1.0 4nct Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4NCTC Q13627 134 479 763.0 2K2:501 Type1 Inactive DFGin 7.716 15.479 BLAminus -129.64, 158.78 69.37, 79.12 -97.74, 33.39 284.73, 80.36 -86.72, -36.3 in-in in 8.64 Saltbr-in 2.724 HRD-in -62.5, -46.61 84.64, -8.34 in-in-out SNCiio in-out ActLoopNT-in 3.262 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -141.23, 169.47 APE9-dihe-na 67.55, 148.75 APE8-dihe-in -69.0, 145.46 APE8-rot-in 286.67 APE67-dihe-in -54.3, -28.09 -54.21, -53.36 APE12-dist-out 14.259 APE11-dist-in 12.041 APE10-dist-out 8.519 APE9-dist-in 3.205 None SEP301,PTR321 SEP301,PTR321 XRAY 2.597 0.21 0.249 C 368 341 5 0 0 0 [[159, 479]] 1.0 4nct Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 4NCTD Q13627 134 480 763.0 2K2:501 Type1 Inactive DFGin 7.679 15.463 BLAminus -116.8, 164.71 65.44, 83.98 -98.76, 30.67 288.35, 84.66 -82.45, -24.84 in-in in 8.59 Saltbr-in 2.683 HRD-in -56.14, -45.28 80.34, 2.84 in-in-out SNCiio in-out ActLoopNT-in 3.216 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -143.29, 160.78 APE9-dihe-na 73.56, 144.01 APE8-dihe-in -64.76, 138.99 APE8-rot-in 292.07 APE67-dihe-in -62.66, -32.93 -50.17, -43.53 APE12-dist-out 14.251 APE11-dist-in 12.008 APE10-dist-out 8.504 APE9-dist-in 3.31 None PTR321 PTR321 XRAY 2.597 0.21 0.249 D 368 332 15 0 0 0 [[159, 479]] 1.0 4nct Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A3XA Q13627 134 481 763.0 QIV:1482 Type1 Inactive DFGin 7.664 15.187 BLAminus -121.3, 168.45 66.25, 87.13 -106.05, 27.07 283.2, 80.21 -83.81, -17.62 in-in in 8.617 Saltbr-in 2.997 HRD-in -59.25, -48.79 80.55, -0.05 in-in-out SNCiio in-out ActLoopNT-in 3.11 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -138.85, 162.88 APE9-dihe-na 69.36, 143.48 APE8-dihe-in -71.67, 143.32 APE8-rot-in 287.54 APE67-dihe-in -58.85, -26.94 -58.65, -43.64 APE12-dist-in 13.952 APE11-dist-in 12.011 APE10-dist-out 8.258 APE9-dist-in 3.21 None PTR321 PTR321 XRAY 2.26 0.236 0.259 A 368 343 5 0 0 0 [[159, 479]] 1.0 5a3x Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A3XB Q13627 133 481 763.0 QIV:1482 Type1 Inactive DFGin 7.772 15.505 BLAminus -125.81, 167.9 65.94, 85.46 -101.51, 31.91 279.0, 78.69 -86.09, -27.09 in-in in 8.599 Saltbr-in 2.745 HRD-in -56.46, -45.32 74.34, 3.15 in-in-out SNCiio in-out ActLoopNT-in 2.725 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -137.85, 164.62 APE9-dihe-na 69.98, 148.5 APE8-dihe-in -66.5, 143.45 APE8-rot-in 290.78 APE67-dihe-in -60.87, -33.02 -55.76, -43.48 APE12-dist-out 14.034 APE11-dist-in 11.882 APE10-dist-out 8.292 APE9-dist-in 3.258 None PTR321 PTR321 XRAY 2.26 0.236 0.259 B 368 341 8 0 0 0 [[159, 479]] 1.0 5a3x Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A3XC Q13627 134 481 763.0 QIV:1482 Type1 Inactive DFGin 7.235 14.805 BLAminus -120.77, 156.43 72.71, 88.81 -105.04, 42.02 290.66, 77.33 -99.01, -30.56 in-in in 8.549 Saltbr-in 2.645 HRD-in -62.04, -42.75 76.63, -18.75 in-in-out SNCiio in-out ActLoopNT-in 2.77 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -123.59, -60.32 APE9-dihe-na -74.24, 162.28 APE8-dihe-in -68.19, 134.61 APE8-rot-in 295.26 APE67-dihe-in -59.28, -25.8 -56.62, -43.45 APE12-dist-in 13.971 APE11-dist-in 12.104 APE10-dist-out 8.003 APE9-dist-in 3.467 None PTR321 PTR321 XRAY 2.26 0.236 0.259 C 368 334 14 0 0 0 [[159, 479]] 1.0 5a3x Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A3XD Q13627 134 480 763.0 QIV:1481 Type1 Inactive DFGin 7.745 15.107 BLAminus -112.42, 164.72 67.39, 90.55 -104.31, 19.84 285.07, 76.07 -77.1, -18.41 in-in in 8.438 Saltbr-in 2.756 HRD-in -55.52, -51.58 81.21, 8.94 in-in-out SNCiio in-out ActLoopNT-in 3.003 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -143.8, 163.41 APE9-dihe-na 70.65, 146.94 APE8-dihe-in -69.56, 144.9 APE8-rot-in 290.59 APE67-dihe-in -57.48, -32.7 -57.78, -42.42 APE12-dist-out 14.424 APE11-dist-in 12.129 APE10-dist-out 8.513 APE9-dist-in 3.22 None PTR321 PTR321 XRAY 2.26 0.236 0.259 D 368 332 15 0 0 0 [[159, 479]] 1.0 5a3x Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4EC Q13627 134 473 763.0 7QQ:1475 Type1 Inactive DFGin 7.237 14.787 BLAminus -138.1, 157.66 68.63, 87.31 -107.74, 30.93 287.87, 90.33 -77.47, -44.69 in-out in 8.675 Saltbr-out 4.117 HRD-in -57.3, -42.31 66.35, 18.38 out-in-out SNCoio in-out ActLoopNT-in 2.822 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -106.87, 162.91 APE9-dihe-na 69.03, 158.68 APE8-dihe-in -76.06, 149.31 APE8-rot-in 284.97 APE67-dihe-in -59.95, -35.01 -52.77, -51.14 APE12-dist-in 13.793 APE11-dist-in 11.825 APE10-dist-out 8.193 APE9-dist-in 3.39 None PTR321 PTR321 XRAY 2.68 0.237 0.268 C 368 263 83 0 0 0 [[159, 479]] 1.0 5a4e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4LB Q13627 133 480 763.0 ZC3:1481 Type1 Inactive DFGin 7.225 15.318 BLAminus -122.33, 174.38 63.37, 78.82 -100.66, 29.63 272.85, 85.35 -76.48, -46.67 in-in in 8.833 Saltbr-in 2.811 HRD-in -57.78, -46.91 78.18, -18.11 in-in-out SNCiio in-out ActLoopNT-in 3.43 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -127.68, 167.12 APE9-dihe-na 66.14, 152.91 APE8-dihe-in -68.52, 139.01 APE8-rot-in 283.99 APE67-dihe-in -47.52, -39.04 -51.76, -60.03 APE12-dist-in 13.532 APE11-dist-in 11.715 APE10-dist-out 8.072 APE9-dist-in 3.289 None PTR321 PTR321 XRAY 2.73 0.224 0.267 B 368 340 8 0 0 0 [[159, 479]] 1.0 5a4l Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4LC Q13627 135 479 763.0 ZC3:1480 Type1 Inactive DFGin 7.006 14.913 BLAminus -127.3, 155.33 73.19, 93.96 -111.33, 27.03 285.01, 85.59 -87.36, -7.31 in-in in 8.652 Saltbr-in 2.868 HRD-in -55.97, -40.82 79.57, -27.3 in-out-out SNCioo out-out ActLoopNT-out 3.704 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -124.41, 154.1 APE9-dihe-na 82.43, 157.05 APE8-dihe-in -75.01, 149.63 APE8-rot-in 309.36 APE67-dihe-in -58.73, -24.55 -56.34, -55.91 APE12-dist-in 13.808 APE11-dist-in 12.046 APE10-dist-out 8.197 APE9-dist-in 3.158 None PTR321 PTR321 XRAY 2.73 0.224 0.267 C 368 333 12 0 0 0 [[159, 479]] 1.0 5a4l Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4QA Q13627 134 480 763.0 Y3L:1482 Type1 Inactive DFGin 7.38 14.947 BLAminus -121.96, 169.12 70.4, 82.32 -101.36, 21.61 281.14, 85.06 -74.47, -27.67 in-in in 8.557 Saltbr-in 2.795 HRD-in -68.17, -45.62 80.68, 0.25 in-in-out SNCiio in-out ActLoopNT-in 3.014 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -134.46, 166.81 APE9-dihe-na 68.32, 157.62 APE8-dihe-in -82.19, 145.27 APE8-rot-in 292.08 APE67-dihe-in -61.8, -22.63 -55.55, -46.76 APE12-dist-in 13.736 APE11-dist-in 11.739 APE10-dist-out 8.013 APE9-dist-in 3.183 None PTR321 PTR321 XRAY 2.37 0.208 0.243 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a4q Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4QC Q13627 135 479 763.0 Y3L:1481 Type1 Inactive DFGin 7.364 15.042 BLAminus -123.78, 162.78 68.52, 86.63 -104.38, 24.62 284.41, 77.47 -79.32, -18.49 in-in in 8.564 Saltbr-in 2.739 HRD-in -62.28, -44.19 78.26, -0.42 in-in-out SNCiio in-out ActLoopNT-in 3.42 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -129.11, 155.72 APE9-dihe-na 82.33, 164.45 APE8-dihe-in -86.88, 143.97 APE8-rot-out 35.24 APE67-dihe-in -42.95, -31.53 -51.33, -61.96 APE12-dist-in 13.912 APE11-dist-in 11.966 APE10-dist-out 8.185 APE9-dist-in 3.243 None PTR321 PTR321 XRAY 2.37 0.208 0.243 C 368 333 12 0 0 0 [[159, 479]] 1.0 5a4q Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A4TC Q13627 135 479 763.0 AJG:1481 Type1 Inactive DFGin 7.147 15.179 BLAminus -129.41, 163.24 71.43, 82.89 -101.13, 32.11 287.17, 80.63 -81.63, -18.22 in-in in 8.495 Saltbr-in 2.998 HRD-in -61.24, -38.7 67.95, 6.62 in-in-out SNCiio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -116.62, 167.66 APE9-dihe-na 72.77, 139.58 APE8-dihe-in -64.52, 140.24 APE8-rot-out 38.46 APE67-dihe-in -54.94, -25.91 -49.67, -56.28 APE12-dist-in 13.98 APE11-dist-in 12.084 APE10-dist-out 8.048 APE9-dist-in 3.265 None PTR321 PTR321 XRAY 2.15 0.205 0.234 C 368 333 12 0 0 0 [[159, 479]] 1.0 5a4t Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 5A54C Q13627 135 479 763.0 5PW:1481 Type1 Inactive DFGin 7.357 15.035 BLAminus -136.48, 159.35 67.91, 80.5 -97.98, 19.65 286.78, 80.5 -74.6, -18.1 in-in in 8.603 Saltbr-in 3.392 HRD-in -58.19, -39.79 67.18, 10.59 in-in-out SNCiio in-out ActLoopNT-in 3.295 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -123.3, 160.72 APE9-dihe-na 73.36, 165.79 APE8-dihe-in -83.62, 148.27 APE8-rot-in 290.99 APE67-dihe-in -61.27, -24.7 -54.62, -49.48 APE12-dist-out 14.125 APE11-dist-in 12.294 APE10-dist-out 8.351 APE9-dist-in 3.067 None PTR321 PTR321 XRAY 2.63 0.224 0.255 C 368 333 12 0 0 0 [[159, 479]] 1.0 5a54 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIFB Q13627 133 480 763.0 B5T:501 Type1 Inactive DFGin 7.437 15.011 BLAminus -117.53, 169.82 65.45, 81.5 -101.1, 26.98 294.5, 81.24 -78.02, -31.68 in-in in 8.976 Saltbr-in 2.829 HRD-in -63.16, -42.31 73.8, 14.91 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -135.66, 162.2 APE9-dihe-na 65.08, 155.43 APE8-dihe-in -69.9, 152.14 APE8-rot-in 294.46 APE67-dihe-in -60.84, -36.77 -65.76, -40.73 APE12-dist-out 14.096 APE11-dist-in 11.816 APE10-dist-out 8.23 APE9-dist-in 3.428 None PTR321 PTR321 XRAY 2.22 0.22 0.25 B 368 338 10 0 0 0 [[159, 479]] 1.0 6eif Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIFC Q13627 135 479 763.0 B5T:501 Type1 Inactive DFGin 7.626 14.968 BLAminus -125.16, 167.64 65.65, 86.42 -102.01, 28.2 285.76, 74.26 -70.95, -35.41 in-in in 8.71 Saltbr-in 3.053 HRD-in -64.14, -45.72 70.72, 21.75 in-in-out SNCiio in-out ActLoopNT-in 2.79 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -144.86, 166.67 APE9-dihe-na 68.87, 169.54 APE8-dihe-in -80.46, 148.42 APE8-rot-in 289.45 APE67-dihe-in -66.62, -23.66 -60.62, -43.05 APE12-dist-out 14.237 APE11-dist-in 12.046 APE10-dist-out 8.222 APE9-dist-in 3.494 None PTR321 PTR321 XRAY 2.22 0.22 0.25 C 368 317 28 0 0 0 [[159, 479]] 1.0 6eif Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIFD Q13627 134 479 763.0 B5T:501 Type1 Inactive DFGin 7.545 15.131 BLAminus -129.8, 155.34 72.75, 87.67 -101.7, 34.46 287.1, 75.24 -73.21, -33.11 in-in in 8.874 Saltbr-in 2.757 HRD-in -60.8, -47.28 75.52, 7.01 in-in-out SNCiio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -135.58, 162.36 APE9-dihe-na 71.89, 152.04 APE8-dihe-in -66.91, 143.91 APE8-rot-out 183.99 APE67-dihe-in -59.93, -30.1 -58.92, -45.25 APE12-dist-out 14.091 APE11-dist-in 11.962 APE10-dist-out 8.149 APE9-dist-in 3.292 None PTR321 PTR321 XRAY 2.22 0.22 0.25 D 368 331 15 0 0 0 [[159, 479]] 1.0 6eif Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIJA Q13627 134 480 763.0 B5Z:501 Type1 Inactive DFGin 7.364 15.562 BLAminus -121.9, 173.42 62.65, 84.26 -101.23, 24.54 287.56, 69.73 -71.05, -32.94 in-out in 9.316 Saltbr-out 4.407 HRD-in -64.87, -43.16 72.94, 6.35 out-in-in SNCoii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.18, 163.75 APE9-dihe-na 69.36, 155.02 APE8-dihe-in -79.85, 135.64 APE8-rot-in 297.55 APE67-dihe-in -62.23, -27.92 -43.08, -47.75 APE12-dist-in 13.698 APE11-dist-in 11.612 APE10-dist-in 7.695 APE9-dist-in 3.216 None PTR321 PTR321 XRAY 2.42 0.215 0.242 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eij Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EILB Q13627 133 480 763.0 B6B:501 Type1 Inactive DFGin 7.341 14.861 BLAminus -128.37, 170.63 59.71, 81.26 -96.98, 27.13 287.97, 84.89 -67.89, -37.04 in-in in 8.814 Saltbr-in 2.913 HRD-in -65.15, -42.63 79.56, -12.9 in-in-out SNCiio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -124.14, 168.7 APE9-dihe-na 64.39, 148.37 APE8-dihe-in -69.18, 141.68 APE8-rot-in 298.05 APE67-dihe-in -55.34, -29.83 -58.23, -45.83 APE12-dist-in 13.832 APE11-dist-in 11.929 APE10-dist-out 8.154 APE9-dist-in 3.28 None PTR321 PTR321 XRAY 2.465 0.213 0.254 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eil Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EILD Q13627 134 479 763.0 B6B:501 Type1 Inactive DFGin 7.448 15.158 BLAminus -126.14, 168.46 63.24, 83.44 -99.13, 27.73 285.72, 76.69 -71.9, -27.65 in-in in 8.93 Saltbr-in 3.07 HRD-in -62.89, -42.01 72.08, 9.2 in-in-out SNCiio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -133.3, 168.91 APE9-dihe-na 66.72, 148.4 APE8-dihe-in -67.25, 141.01 APE8-rot-in 291.85 APE67-dihe-in -57.62, -29.33 -53.66, -47.87 APE12-dist-in 13.925 APE11-dist-in 11.798 APE10-dist-out 8.029 APE9-dist-in 3.279 None PTR321 PTR321 XRAY 2.465 0.213 0.254 D 368 333 13 0 0 0 [[159, 479]] 1.0 6eil Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIPA Q13627 134 480 763.0 B7B:501 Type1 Inactive DFGin 7.259 15.24 BLAminus -125.43, 172.01 62.72, 86.19 -100.26, 27.0 284.48, 74.29 -66.18, -40.51 in-out in 8.947 Saltbr-out 3.641 HRD-in -62.34, -44.05 75.6, 8.2 out-in-in SNCoii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.2, 165.59 APE9-dihe-na 64.6, 153.96 APE8-dihe-in -70.09, 140.96 APE8-rot-in 288.47 APE67-dihe-in -58.27, -33.16 -55.85, -46.32 APE12-dist-in 13.589 APE11-dist-in 11.661 APE10-dist-in 7.786 APE9-dist-in 3.253 None PTR321 PTR321 XRAY 2.56 0.243 0.266 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIPC Q13627 135 479 763.0 B7B:501 Type1 Inactive DFGin 7.364 15.276 BLAminus -125.37, 158.18 59.75, 86.95 -98.2, 25.76 287.16, 77.19 -71.86, -22.77 in-in in 8.799 Saltbr-in 3.16 HRD-in -69.43, -41.36 66.86, 11.92 in-in-out SNCiio in-out ActLoopNT-in 3.055 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -123.33, 159.25 APE9-dihe-na 71.82, 144.57 APE8-dihe-in -70.74, 143.31 APE8-rot-out 53.41 APE67-dihe-in -64.2, -26.78 -50.51, -45.83 APE12-dist-out 14.057 APE11-dist-in 11.942 APE10-dist-out 8.124 APE9-dist-in 3.321 None PTR321 PTR321 XRAY 2.56 0.243 0.266 C 368 339 6 0 0 0 [[159, 479]] 1.0 6eip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIQA Q13627 134 480 763.0 B6Z:501 Type1 Inactive DFGin 7.844 15.002 BLAminus -118.74, 166.17 66.15, 80.44 -94.35, 21.46 285.58, 78.61 -71.38, -21.76 in-in in 8.611 Saltbr-in 2.926 HRD-in -64.07, -39.42 69.31, 1.03 in-in-out SNCiio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -140.51, 163.19 APE9-dihe-na 69.7, 156.6 APE8-dihe-in -69.88, 140.03 APE8-rot-in 262.24 APE67-dihe-in -50.14, -33.52 -54.08, -50.81 APE12-dist-in 13.87 APE11-dist-in 12.058 APE10-dist-out 8.058 APE9-dist-in 3.177 None PTR321 PTR321 XRAY 2.3 0.22 0.252 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eiq Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIQB Q13627 133 480 763.0 B6Z:501 Type1 Inactive DFGin 7.297 14.849 BLAminus -120.11, 166.43 71.57, 79.73 -95.19, 22.26 288.5, 77.93 -74.27, -18.06 in-in in 8.849 Saltbr-in 3.152 HRD-in -55.6, -50.6 83.2, -26.1 in-in-out SNCiio in-out ActLoopNT-in 2.76 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -126.72, 167.31 APE9-dihe-na 70.71, 154.35 APE8-dihe-in -72.28, 149.56 APE8-rot-in 304.02 APE67-dihe-in -63.36, -28.5 -63.02, -48.04 APE12-dist-out 14.336 APE11-dist-in 12.172 APE10-dist-out 8.104 APE9-dist-in 3.421 None PTR321 PTR321 XRAY 2.3 0.22 0.252 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eiq Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIQC Q13627 135 479 763.0 B6Z:501 Type1 Inactive DFGin 7.468 15.222 BLAminus -135.44, 157.29 69.01, 84.56 -97.19, 20.1 284.91, 77.49 -65.57, -27.64 in-in in 8.968 Saltbr-in 3.256 HRD-in -67.8, -34.77 66.66, 7.84 in-in-out SNCiio in-out ActLoopNT-in 2.69 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -132.75, 173.41 APE9-dihe-na 67.43, 156.08 APE8-dihe-in -71.33, 140.62 APE8-rot-in 274.81 APE67-dihe-in -64.01, -26.61 -57.83, -37.82 APE12-dist-out 14.005 APE11-dist-in 12.18 APE10-dist-out 8.189 APE9-dist-in 3.321 None PTR321 PTR321 XRAY 2.3 0.22 0.252 C 368 333 12 0 0 0 [[159, 479]] 1.0 6eiq Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIRA Q13627 134 480 763.0 B6H:501 Type1 Inactive DFGin 7.393 14.795 BLAminus -125.18, 166.81 63.57, 86.84 -99.28, 31.63 287.87, 74.48 -70.6, -35.95 in-in in 8.782 Saltbr-in 2.895 HRD-in -63.53, -49.11 75.82, 12.8 in-in-out SNCiio in-out ActLoopNT-in 3.052 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -140.45, 163.14 APE9-dihe-na 68.93, 157.09 APE8-dihe-in -74.57, 134.52 APE8-rot-in 295.13 APE67-dihe-in -54.09, -35.75 -49.98, -47.46 APE12-dist-in 13.834 APE11-dist-in 11.859 APE10-dist-out 8.03 APE9-dist-in 3.209 None PTR321 PTR321 XRAY 2.4 0.235 0.258 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eir Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIRB Q13627 133 480 763.0 B6H:501 Type1 Inactive DFGin 7.276 14.735 BLAminus -119.78, 174.81 68.91, 77.35 -98.17, 20.3 285.13, 87.39 -69.57, -27.99 in-in in 8.712 Saltbr-in 2.955 HRD-in -65.48, -40.64 68.84, 5.47 in-in-out SNCiio in-out ActLoopNT-in 2.731 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -144.55, 153.93 APE9-dihe-na 72.69, 153.36 APE8-dihe-in -69.83, 136.66 APE8-rot-in 293.84 APE67-dihe-in -59.39, -29.71 -51.99, -43.85 APE12-dist-out 14.548 APE11-dist-in 11.935 APE10-dist-out 8.485 APE9-dist-in 3.178 None PTR321 PTR321 XRAY 2.4 0.235 0.258 B 368 335 13 0 0 0 [[159, 479]] 1.0 6eir Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIRC Q13627 135 479 763.0 B6H:501 Type1 Inactive DFGin 7.412 15.039 BLAminus -130.82, 163.5 66.19, 85.94 -102.57, 28.49 281.77, 74.34 -75.43, -37.22 in-in in 8.512 Saltbr-in 2.752 HRD-in -65.03, -38.44 68.49, 5.65 in-in-out SNCiio in-out ActLoopNT-in 3.18 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -126.14, 166.06 APE9-dihe-na 64.03, 157.33 APE8-dihe-in -71.3, 146.96 APE8-rot-in 289.92 APE67-dihe-in -58.68, -32.01 -54.63, -47.82 APE12-dist-in 13.847 APE11-dist-in 11.909 APE10-dist-out 8.196 APE9-dist-in 3.124 None PTR321 PTR321 XRAY 2.4 0.235 0.258 C 368 333 12 0 0 0 [[159, 479]] 1.0 6eir Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIRD Q13627 134 479 763.0 B6H:501 Type1 Inactive DFGin 7.412 15.089 BLAminus -128.73, 160.15 68.25, 89.2 -103.65, 29.38 289.19, 75.86 -72.84, -26.68 in-in in 8.657 Saltbr-in 2.915 HRD-in -59.93, -46.06 73.72, 10.04 in-in-out SNCiio in-out ActLoopNT-in 2.872 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -138.86, 161.67 APE9-dihe-na 67.2, 154.51 APE8-dihe-in -70.63, 143.22 APE8-rot-in 290.43 APE67-dihe-in -57.31, -33.06 -57.15, -43.79 APE12-dist-out 14.027 APE11-dist-in 11.781 APE10-dist-in 7.978 APE9-dist-in 3.306 None PTR321 PTR321 XRAY 2.4 0.235 0.258 D 368 333 13 0 0 0 [[159, 479]] 1.0 6eir Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EISA Q13627 134 480 763.0 B6N:501 Type1 Inactive DFGin 7.388 15.073 BLAminus -121.06, 176.79 59.09, 85.05 -102.98, 23.5 282.6, 78.49 -72.76, -28.73 in-in in 8.522 Saltbr-in 2.684 HRD-in -60.79, -45.9 71.73, 8.72 in-in-out SNCiio in-out ActLoopNT-in 2.965 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -123.11, 168.92 APE9-dihe-na 67.38, 154.43 APE8-dihe-in -70.15, 143.5 APE8-rot-in 292.25 APE67-dihe-in -58.07, -26.24 -55.8, -46.96 APE12-dist-in 13.889 APE11-dist-in 11.917 APE10-dist-out 8.032 APE9-dist-in 3.263 None PTR321 PTR321 XRAY 2.36 0.223 0.262 A 368 345 2 0 0 0 [[159, 479]] 1.0 6eis Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EISC Q13627 135 479 763.0 B6N:501 Type1 Inactive DFGin 7.252 15.079 BLAminus -126.53, 168.59 63.16, 91.31 -107.92, 22.87 278.58, 80.44 -66.2, -35.95 in-in in 8.493 Saltbr-in 2.624 HRD-in -60.79, -42.31 68.89, 12.84 in-in-out SNCiio in-out ActLoopNT-in 2.758 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -121.65, 170.02 APE9-dihe-na 65.71, 162.09 APE8-dihe-in -78.55, 143.24 APE8-rot-in 293.4 APE67-dihe-in -58.46, -25.81 -54.9, -49.25 APE12-dist-in 13.875 APE11-dist-in 11.986 APE10-dist-out 8.187 APE9-dist-in 3.364 None PTR321 PTR321 XRAY 2.36 0.223 0.262 C 368 341 4 0 0 0 [[159, 479]] 1.0 6eis Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIVA Q13627 134 480 763.0 B6Q:501 Type1 Inactive DFGin 7.555 15.152 BLAminus -120.84, 171.67 57.39, 86.98 -102.78, 35.14 274.84, 85.24 -78.55, -29.99 in-in in 8.863 Saltbr-in 2.667 HRD-in -64.41, -32.42 61.66, 3.26 in-in-out SNCiio in-out ActLoopNT-in 2.583 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -115.94, 171.35 APE9-dihe-na 64.29, 157.62 APE8-dihe-in -72.84, 149.54 APE8-rot-in 294.84 APE67-dihe-in -70.56, -22.33 -58.23, -37.84 APE12-dist-in 13.979 APE11-dist-in 11.914 APE10-dist-out 8.132 APE9-dist-in 3.157 None PTR321 PTR321 XRAY 2.68 0.2 0.235 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eiv Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIVB Q13627 133 480 763.0 B6Q:501 Type1 Inactive DFGin 7.838 15.054 BLAminus -117.46, 173.9 54.13, 86.38 -99.45, 36.06 278.29, 87.94 -79.83, -33.89 in-in in 9.001 Saltbr-in 2.687 HRD-in -72.2, -37.83 60.09, 15.76 in-in-out SNCiio in-out ActLoopNT-in 3.031 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -115.67, 152.23 APE9-dihe-na 68.73, 155.27 APE8-dihe-in -64.12, 146.96 APE8-rot-in 304.3 APE67-dihe-in -70.42, -38.71 -50.76, -42.3 APE12-dist-out 14.313 APE11-dist-in 11.293 APE10-dist-out 8.714 APE9-dist-in 3.185 None PTR321 PTR321 XRAY 2.68 0.2 0.235 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eiv Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIVC Q13627 135 479 763.0 B6Q:501 Type1 Inactive DFGin 7.974 15.09 BLAminus -130.5, 162.34 68.37, 85.75 -108.43, 38.06 286.93, 86.81 -88.65, -21.51 in-in in 8.82 Saltbr-in 3.056 HRD-in -63.41, -36.37 61.31, 16.95 in-in-out SNCiio in-out ActLoopNT-in 3.132 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -105.82, 169.53 APE9-dihe-na 68.49, 151.95 APE8-dihe-in -66.67, 153.42 APE8-rot-out 50.58 APE67-dihe-in -66.4, -29.21 -58.54, -50.01 APE12-dist-out 14.024 APE11-dist-in 12.006 APE10-dist-out 8.071 APE9-dist-in 3.196 None PTR321 PTR321 XRAY 2.68 0.2 0.235 C 368 333 12 0 0 0 [[159, 479]] 1.0 6eiv Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIVD Q13627 134 479 763.0 B6Q:501 Type1 Inactive DFGin 7.858 14.788 BLAminus -123.28, 170.55 60.69, 87.47 -104.63, 40.75 289.41, 79.15 -84.06, -24.98 in-in in 8.939 Saltbr-in 3.077 HRD-in -80.96, -33.53 58.1, 20.23 in-in-out SNCiio in-out ActLoopNT-in 2.757 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -123.8, 169.26 APE9-dihe-na 65.27, 152.41 APE8-dihe-in -65.12, 144.68 APE8-rot-in 294.25 APE67-dihe-in -62.96, -33.45 -60.21, -40.79 APE12-dist-in 13.884 APE11-dist-in 11.72 APE10-dist-out 8.139 APE9-dist-in 3.184 None PTR321 PTR321 XRAY 2.68 0.2 0.235 D 368 333 13 0 0 0 [[159, 479]] 1.0 6eiv Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EJ4A Q13627 134 480 763.0 B7W:501 Type1 Inactive DFGin 7.338 14.948 BLAminus -132.19, 174.27 73.69, 75.25 -98.32, 20.37 284.23, 94.63 -75.42, -26.2 in-out in 8.869 Saltbr-out 4.041 HRD-in -58.96, -48.23 70.58, 13.6 out-in-out SNCoio in-out ActLoopNT-in 2.854 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -125.35, 166.33 APE9-dihe-na 69.65, 156.05 APE8-dihe-in -76.23, 139.99 APE8-rot-in 286.29 APE67-dihe-in -51.41, -21.41 -54.65, -48.5 APE12-dist-in 13.897 APE11-dist-in 11.661 APE10-dist-out 8.075 APE9-dist-in 3.187 None PTR321 PTR321 XRAY 2.88 0.222 0.27 A 368 344 3 0 0 0 [[159, 479]] 1.0 6ej4 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EJ4B Q13627 133 480 763.0 B7W:501 Type1 Inactive DFGin 7.107 14.76 BLAminus -124.17, 168.72 61.19, 91.64 -101.7, 11.62 289.3, 74.52 -55.92, -30.33 in-in in 8.759 Saltbr-in 2.833 HRD-in -65.73, -48.81 75.08, 26.7 in-in-out SNCiio in-out ActLoopNT-in 3.123 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -164.85, 149.17 APE9-dihe-na 68.91, 175.03 APE8-dihe-in -91.13, 144.68 APE8-rot-in 309.9 APE67-dihe-in -69.08, -39.33 -60.28, -35.15 APE12-dist-in 13.849 APE11-dist-in 11.526 APE10-dist-out 8.561 APE9-dist-in 3.913 None PTR321 PTR321 XRAY 2.88 0.222 0.27 B 368 338 10 0 0 0 [[159, 479]] 1.0 6ej4 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EJ4D Q13627 134 479 763.0 B7W:501 Type1 Inactive DFGin 7.849 14.665 BLAminus -127.93, 170.7 58.86, 87.06 -99.94, 27.16 296.94, 82.16 -71.66, -18.74 in-in in 8.69 Saltbr-in 2.71 HRD-in -59.65, -49.19 78.06, 3.89 in-in-out SNCiio in-out ActLoopNT-in 3.11 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.94, 163.29 APE9-dihe-na 74.33, 157.36 APE8-dihe-in -70.12, 155.62 APE8-rot-in 287.38 APE67-dihe-in -63.74, -29.78 -64.08, -46.32 APE12-dist-out 14.079 APE11-dist-in 11.966 APE10-dist-in 7.846 APE9-dist-in 3.243 None PTR321 PTR321 XRAY 2.88 0.222 0.27 D 368 331 15 0 0 0 [[159, 479]] 1.0 6ej4 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6YF8C Q13627 135 479 763.0 OPW:501 Type1 Inactive DFGin 7.06 14.935 BLAminus -124.46, 168.16 66.21, 86.05 -102.5, 27.56 285.91, 74.18 -71.62, -35.88 in-in in 8.498 Saltbr-in 2.557 HRD-in -64.26, -45.7 70.47, 20.75 in-in-out SNCiio in-out ActLoopNT-in 2.786 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.66, 167.21 APE9-dihe-na 69.24, 168.75 APE8-dihe-in -80.92, 148.18 APE8-rot-out 33.92 APE67-dihe-in -67.11, -24.9 -61.32, -43.38 APE12-dist-in 13.864 APE11-dist-in 11.499 APE10-dist-in 7.931 APE9-dist-in 3.227 None PTR321 PTR321 XRAY 3.198 0.251 0.283 C 368 333 12 0 0 0 [[159, 479]] 1.0 6yf8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A4WB Q13627 134 481 763.0 QYH:501 Type1 Inactive DFGin 7.23 14.867 BLAminus -127.1, 165.63 77.7, 82.87 -96.17, 24.09 286.93, 79.55 -67.49, -32.84 in-in in 8.601 Saltbr-in 2.743 HRD-in -59.27, -48.69 70.77, 5.13 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -89.37, 163.93 APE9-dihe-na 72.54, 147.59 APE8-dihe-in -66.14, 133.19 APE8-rot-in 287.48 APE67-dihe-in -59.02, -29.56 -43.35, -51.99 APE12-dist-out 14.059 APE11-dist-in 12.004 APE10-dist-in 7.669 APE9-dist-in 3.117 None PTR321 PTR321 XRAY 2.7 0.165 0.205 B 382 341 7 0 0 0 [[159, 479]] 1.0 7a4w Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A55B Q13627 134 481 763.0 QZ2:501 Type1 Inactive DFGin 7.224 14.978 BLAminus -126.6, 167.5 73.14, 85.31 -100.14, 23.23 283.45, 82.86 -73.5, -24.04 in-in in 8.585 Saltbr-in 2.766 HRD-in -64.22, -46.85 72.39, 0.81 in-in-out SNCiio in-out ActLoopNT-in 2.962 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -88.13, 163.49 APE9-dihe-na 76.28, 147.59 APE8-dihe-in -62.05, 132.27 APE8-rot-in 298.44 APE67-dihe-in -60.88, -26.56 -41.66, -52.05 APE12-dist-out 14.126 APE11-dist-in 12.031 APE10-dist-in 7.602 APE9-dist-in 3.12 None PTR321 PTR321 XRAY 2.2 0.182 0.225 B 382 341 7 0 0 0 [[159, 479]] 1.0 7a55 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7A5BB Q13627 134 481 763.0 MFR:501 Type1 Inactive DFGin 7.363 14.842 BLAminus -128.7, 170.78 69.52, 88.76 -102.46, 24.68 283.18, 76.24 -69.64, -30.01 in-in in 8.335 Saltbr-in 2.7 HRD-in -58.52, -51.24 77.14, -0.56 in-in-out SNCiio in-out ActLoopNT-in 2.875 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -95.16, 165.26 APE9-dihe-na 71.85, 148.34 APE8-dihe-in -58.61, 134.95 APE8-rot-in 282.87 APE67-dihe-in -61.06, -26.55 -48.36, -47.01 APE12-dist-out 14.169 APE11-dist-in 12.052 APE10-dist-in 7.643 APE9-dist-in 2.983 None PTR321 PTR321 XRAY 2.6 0.155 0.192 B 382 341 7 0 0 0 [[159, 479]] 1.0 7a5b Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7O7KA Q13627 134 480 763.0 6ZV:803,LI:813 Type1,Allosteric Inactive DFGin 7.479 14.978 BLAminus -123.84, 172.32 71.95, 80.41 -97.61, 20.16 282.45, 81.55 -75.41, -18.82 in-in in 8.732 Saltbr-in 2.569 HRD-in -66.95, -44.76 74.49, -2.2 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.45, 171.41 APE9-dihe-na 76.66, 152.25 APE8-dihe-in -71.23, 142.04 APE8-rot-out 204.57 APE67-dihe-in -61.2, -25.53 -57.62, -46.09 APE12-dist-in 13.826 APE11-dist-in 12.396 APE10-dist-in 7.934 APE9-dist-in 3.209 None PTR321 PTR321 XRAY 1.82 0.179 0.205 A 361 345 2 0 0 0 [[159, 479]] 1.0 7o7k Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7O7KB Q13627 133 480 763.0 6ZV:504,LI:516 Type1,Allosteric Inactive DFGin 7.549 15.002 BLAminus -123.44, 173.38 69.65, 80.66 -97.78, 19.84 280.19, 88.12 -76.56, -16.84 in-in in 8.721 Saltbr-in 2.45 HRD-in -66.14, -44.61 73.06, -2.94 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -122.41, 168.28 APE9-dihe-na 77.46, 151.66 APE8-dihe-in -70.04, 138.71 APE8-rot-out 178.34 APE67-dihe-in -60.28, -25.12 -56.13, -47.11 APE12-dist-in 13.885 APE11-dist-in 12.364 APE10-dist-out 8.042 APE9-dist-in 3.108 None PTR321 PTR321 XRAY 1.82 0.179 0.205 B 361 345 3 0 0 0 [[159, 479]] 1.0 7o7k Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6EIJC Q13627 135 479 763.0 B5Z:501 Type1.5_Front Inactive DFGin 7.322 15.822 BLAminus -119.52, 178.29 74.66, 62.43 -90.76, 17.19 281.65, 84.11 -79.88, -15.93 in-in in 8.813 Saltbr-in 2.837 HRD-in -61.62, -44.31 72.29, 10.77 in-in-out SNCiio in-out ActLoopNT-in 3.127 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -131.72, 163.63 APE9-dihe-na 69.62, 151.36 APE8-dihe-in -71.38, 142.46 APE8-rot-in 288.31 APE67-dihe-in -55.52, -31.51 -56.59, -47.99 APE12-dist-in 13.973 APE11-dist-in 12.181 APE10-dist-out 8.281 APE9-dist-in 3.331 None PTR321 PTR321 XRAY 2.42 0.215 0.242 C 368 338 7 0 0 0 [[159, 479]] 1.0 6eij Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6UIPA Q13627 131 479 763.0 Q8J:501 Type1 Inactive DFGin 7.329 15.292 None -128.98, -33.2 -83.24, -86.92 68.74, 42.73 287.01, 105.17 -106.11, -43.86 in-in in 8.607 Saltbr-in 2.444 HRD-in -69.31, -45.72 68.49, 1.14 in-in-in SNCiii in-in ActLoopNT-in 3.034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.27, -51.33 APE9-dihe-na -84.83, 157.96 APE8-dihe-in -67.65, 136.35 APE8-rot-in 301.98 APE67-dihe-in -59.01, -29.0 -52.09, -48.51 APE12-dist-in 12.51 APE11-dist-in 10.849 APE10-dist-in 6.989 APE9-dist-in 3.23 None PTR321 PTR321 XRAY 3.7 0.272 0.29 A 361 345 4 0 0 0 [[159, 479]] 1.0 6uip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 9FT2A Q13627 134 480 763.0 A1IE6:501 Type1 Inactive DFGin 7.574 15.895 None -123.41, -159.52 69.59, -109.27 67.33, -3.52 296.76, 96.58 -76.19, -5.59 in-in in 9.144 Saltbr-in 3.298 HRD-in -61.34, -38.17 66.08, 9.45 in-out-out SNCioo out-out ActLoopNT-out 4.114 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -106.57, 172.34 APE9-dihe-na 65.66, 156.83 APE8-dihe-in -69.73, 153.42 APE8-rot-out 183.57 APE67-dihe-in -64.1, -34.34 -62.54, -50.05 APE12-dist-in 11.165 APE11-dist-in 11.868 APE10-dist-in 7.923 APE9-dist-in 3.363 None PTR321 PTR321 XRAY 2.9 0.212 0.235 A 361 342 5 0 0 0 [[159, 479]] 1.0 9ft2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 9FT3A Q13627 134 480 763.0 A1IE7:501 Type1 Inactive DFGin 7.559 15.695 None -120.59, 174.62 87.74, -111.53 67.1, 10.68 308.34, 93.78 -70.59, -9.71 in-in in 8.841 Saltbr-in 2.944 HRD-in -61.2, -47.31 80.25, -0.32 in-out-out SNCioo out-out ActLoopNT-out 4.054 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.45, 165.76 APE9-dihe-na 76.29, 154.85 APE8-dihe-in -77.87, 145.0 APE8-rot-out 181.65 APE67-dihe-in -62.64, -27.73 -60.42, -45.99 APE12-dist-in 11.142 APE11-dist-in 12.008 APE10-dist-in 7.954 APE9-dist-in 3.156 None PTR321 PTR321 XRAY 2.7 0.196 0.23 A 361 342 5 0 0 0 [[159, 479]] 1.0 9ft3 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 9FT4A Q13627 134 480 763.0 A1IFJ:501 Type1 Inactive DFGin 7.628 15.767 None -120.71, -156.86 61.01, -103.63 67.38, -3.25 294.05, 97.87 -71.86, -4.64 in-in in 9.066 Saltbr-in 3.176 HRD-in -62.39, -36.73 64.58, 13.09 in-out-out SNCioo out-out ActLoopNT-out 4.028 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.4, 173.83 APE9-dihe-na 66.37, 159.49 APE8-dihe-in -70.35, 150.45 APE8-rot-out 182.43 APE67-dihe-in -65.5, -29.58 -61.56, -47.55 APE12-dist-in 11.232 APE11-dist-in 11.95 APE10-dist-in 7.918 APE9-dist-in 3.405 None PTR321 PTR321 XRAY 3.0 0.203 0.237 A 361 342 5 0 0 0 [[159, 479]] 1.0 9ft4 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 9FT6A Q13627 134 480 763.0 A1IE8:501 Type1 Inactive DFGin 7.585 15.816 None -126.75, 170.06 89.43, -106.36 68.66, 5.72 299.38, 96.13 -75.78, -8.95 in-in in 9.146 Saltbr-in 3.339 HRD-in -60.11, -40.88 70.11, 5.43 in-out-out SNCioo out-out ActLoopNT-out 3.939 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.56, 172.59 APE9-dihe-na 68.31, 156.56 APE8-dihe-in -68.23, 150.78 APE8-rot-out 177.43 APE67-dihe-in -63.38, -34.6 -61.07, -48.82 APE12-dist-in 11.185 APE11-dist-in 11.902 APE10-dist-in 7.877 APE9-dist-in 3.415 None PTR321 PTR321 XRAY 3.0 0.209 0.25 A 361 342 5 0 0 0 [[159, 479]] 1.0 9ft6 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 9FUFA Q13627 134 480 763.0 A1IFO:501 Type1 Inactive DFGin 7.669 15.743 None -124.23, -170.08 74.82, -105.33 66.79, 7.03 297.99, 97.28 -82.54, -3.73 in-in in 9.004 Saltbr-in 3.007 HRD-in -63.73, -39.36 69.07, 9.77 in-out-out SNCioo out-out ActLoopNT-out 4.112 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.16, 171.47 APE9-dihe-na 67.5, 156.88 APE8-dihe-in -71.53, 145.53 APE8-rot-out 186.89 APE67-dihe-in -63.53, -27.94 -60.87, -45.06 APE12-dist-in 11.194 APE11-dist-in 11.939 APE10-dist-in 7.905 APE9-dist-in 3.309 None PTR321 PTR321 XRAY 2.7 0.21 0.232 A 361 342 5 0 0 0 [[159, 479]] 1.0 9fuf Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 6S11B Q13627 136 480 763.0 KQE:501 Type1 None DFGin 7.321 14.74 BLAminus -122.66, 164.68 70.6, 90.6 -105.94, 27.83 286.74, 77.35 -71.95, -23.72 in-in in 8.564 Saltbr-in 3.103 HRD-in -69.08, -43.23 70.93, 5.16 in-in-none SNCiin in-none ActLoopNT-in 2.871 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -126.36, 176.02 APE9-dihe-na 69.06, 141.8 APE8-dihe-in -64.1, 141.34 APE8-rot-in 291.06 APE67-dihe-in -52.52, -31.33 -58.27, -46.65 APE12-dist-none 999.0 APE11-dist-in 11.465 APE10-dist-in 7.262 APE9-dist-in 3.159 None PTR321 PTR321 XRAY 2.445 0.173 0.21 B 361 330 15 0 0 3 [[159, 479]] 1.0 6s11 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_HUMAN 7Z5NH Q13627 135 480 763.0 3NG:501 Type1 None DFGin 6.679 14.847 BLAminus -128.66, -179.58 53.82, 77.25 -93.05, 20.83 280.85, 75.88 -63.97, -13.6 in-in in 9.075 Saltbr-in 3.001 HRD-in -63.15, -47.83 74.92, 6.9 in-in-none SNCiin in-none ActLoopNT-in 2.799 ActLoopCT-none nonTYR APEdihe_aaini APEdist_niii APE10-dihe-na -156.21, 166.85 APE9-dihe-na 64.29, 161.67 APE8-dihe-in -89.72, 140.84 APE8-rot-none 999.0 APE67-dihe-in -54.39, -32.97 -48.02, -56.25 APE12-dist-none 999.0 APE11-dist-in 10.614 APE10-dist-in 7.767 APE9-dist-in 3.208 None PTR321 PTR321 XRAY 2.77 0.207 0.252 H 370 307 39 0 0 4 [[159, 479]] 1.0 7z5n Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.2e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_MOUSE 9KRJA Q61214 135 480 763.0 No_ligand No_ligand Inactive DFGin 7.451 15.714 ABAminus -130.5, -26.58 -111.46, 99.35 -104.53, 13.98 283.95, 87.78 -86.23, -2.98 in-in in 8.946 Saltbr-in 2.884 HRD-in -73.32, -50.65 74.38, 7.87 in-in-in SNCiii in-in ActLoopNT-in 2.77 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.74, -22.34 APE9-dihe-na -113.07, -179.69 APE8-dihe-in -79.96, 130.35 APE8-rot-in 310.58 APE67-dihe-in -51.39, -33.76 -35.09, -62.13 APE12-dist-in 13.514 APE11-dist-in 11.48 APE10-dist-in 7.823 APE9-dist-in 3.558 None PTR321 PTR321 XRAY 3.0 0.186 0.247 A 763 340 6 0 0 0 [[159, 479]] 1.0 9krj Mus musculus CMGC_DYRK1A_MOUSE CMGC 1e-89 307.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_MOUSE 9KRJB Q61214 136 480 763.0 No_ligand No_ligand Inactive DFGin 7.79 15.626 BLAminus -140.33, 173.1 60.62, 71.97 -83.13, 15.06 282.43, 88.67 -68.38, -9.23 in-in in 8.953 Saltbr-in 2.767 HRD-in -57.11, -52.22 84.12, -14.35 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -113.49, -61.31 APE9-dihe-na -72.2, -179.32 APE8-dihe-in -77.41, 134.56 APE8-rot-in 291.59 APE67-dihe-in -55.78, -30.42 -42.33, -55.06 APE12-dist-out 14.147 APE11-dist-in 12.497 APE10-dist-out 8.132 APE9-dist-in 3.531 None PTR321 PTR321 XRAY 3.0 0.186 0.247 B 763 335 9 0 0 2 [[159, 479]] 1.0 9krj Mus musculus CMGC_DYRK1A_MOUSE CMGC 1e-89 307.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

CMGC_DYRK1A (Dual specificity tyrosine-phosphorylation-regulated kinase 1A)

Total number of chains: 2
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 9KRJA
DFGin BLAminus 1 50.0% 9KRJB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
DYR1A_MOUSE 9KRJA Q61214 135 480 763.0 No_ligand No_ligand Inactive DFGin 7.451 15.714 ABAminus -130.5, -26.58 -111.46, 99.35 -104.53, 13.98 283.95, 87.78 -86.23, -2.98 in-in in 8.946 Saltbr-in 2.884 HRD-in -73.32, -50.65 74.38, 7.87 in-in-in SNCiii in-in ActLoopNT-in 2.77 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.74, -22.34 APE9-dihe-na -113.07, -179.69 APE8-dihe-in -79.96, 130.35 APE8-rot-in 310.58 APE67-dihe-in -51.39, -33.76 -35.09, -62.13 APE12-dist-in 13.514 APE11-dist-in 11.48 APE10-dist-in 7.823 APE9-dist-in 3.558 None PTR321 PTR321 XRAY 3.0 0.186 0.247 A 763 340 6 0 0 0 [[159, 479]] 1.0 9krj Mus musculus CMGC_DYRK1A_MOUSE CMGC 1e-89 307.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYR1A_MOUSE 9KRJB Q61214 136 480 763.0 No_ligand No_ligand Inactive DFGin 7.79 15.626 BLAminus -140.33, 173.1 60.62, 71.97 -83.13, 15.06 282.43, 88.67 -68.38, -9.23 in-in in 8.953 Saltbr-in 2.767 HRD-in -57.11, -52.22 84.12, -14.35 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -113.49, -61.31 APE9-dihe-na -72.2, -179.32 APE8-dihe-in -77.41, 134.56 APE8-rot-in 291.59 APE67-dihe-in -55.78, -30.42 -42.33, -55.06 APE12-dist-out 14.147 APE11-dist-in 12.497 APE10-dist-out 8.132 APE9-dist-in 3.531 None PTR321 PTR321 XRAY 3.0 0.186 0.247 B 763 335 9 0 0 2 [[159, 479]] 1.0 9krj Mus musculus CMGC_DYRK1A_MOUSE CMGC 1e-89 307.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A