6S1I

DYRK1A (Dual specificity tyrosine-phosphorylation-regulated kinase 1A)
Group: CMGC
Uniprot: DYR1A_HUMAN
Organism: Homo sapiens
Domain boundary: 159 - 479
Resolu: 2.38

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in KR8 Type1 135 - 481 0
B Active DFGin BLAminus in-in in-in KR8 Type1 135 - 481 0
C Active DFGin BLAminus in-in in-in KR8 Type1 135 - 481 1
D Active DFGin BLAminus in-in in-in KR8 Type1 135 - 481 1
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain D
       134        144        154        164 
smsshkkerk VYNDGYDDDN YDYIVKNGEK WMDRYEIDSL 
       174        184        194        204 
IGKGSFGQVV KAYDRVEQEW VAIKIIKNKK AFLNQAQIEV 
       214        224        234        244 
RLLELMNKHD TEMKYYIVHL KRHFMFRNHL CLVFEMLSYN 
       254        264        274        284 
LYDLLRNTNF RGVSLNLTRK FAQQMCTALL FLATPELSII 
       294        304        314        324 
HCDLKPENIL LCNPKRSAIK IVDFGSSCQL GQrIYQYIQS 
       334        344        354        364 
RFYRSPEVLL GMPYDLAIDM WSLGCILVEM HTGEPLFSGA 
       374        384        394        404 
NEVDQMNKIV EVLGIPPAHI LDQAPKARKF FEKLPDGTWN 
       414        424        434        444 
LKKTKDGKRE YKPPGTRKLH NILGVETGGP GGRRAGESGH 
       454        464        474        484 
TVADYLKFKD LILRMLDYDP KTRIQPYYAL QHSFFKKtad 

e
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X321