2VX3

DYRK1A (Dual specificity tyrosine-phosphorylation-regulated kinase 1A)
Group: CMGC
Uniprot: DYR1A_HUMAN
Organism: Homo sapiens
Domain boundary: 159 - 479
Resolu: 2.4

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in D15 Type1 135 - 481 0
B Active DFGin BLAminus in-in in-in D15 Type1 135 - 480 0
C Active DFGin BLAminus in-in in-in D15 Type1 135 - 480 0
D Active DFGin BLAminus in-in in-in D15 Type1 135 - 480 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain D
         -          -        133        143 
mhhhhhhssg vdlgtenlyf qsmsshkker kVYNDGYDDD 
       153        163        173        183 
NYDYIVKNGE KWMDRYEIDS LIGKGSFGQV VKAYDRVEQE 
       193        203        213        223 
WVAIKIIKNK KAFLNQAQIE VRLLELMNKH DTEMKYYIVH 
       233        243        253        263 
LKRHFMFRNH LCLVFEMLSY NLYDLLRNTN FRGVSLNLTR 
       273        283        293        303 
KFAQQMCTAL LFLATPELSI IHCDLKPENI LLCNPKRSAI 
       313        323        333        343 
KIVDFGSSCQ LGQRIYQYIQ SRFYRSPEVL LGMPYDLAID 
       353        363        373        383 
MWSLGCILVE MHTGEPLFSG ANEVDQMNKI VEVLGIPPAH 
       393        403        413        423 
ILDQAPKARK FFEKLPDGTW NLKKTkdgKR EYKPPGTRKL 
       433        443        453        463 
HNILGVETGG PGGRRAGESG HTVADYLKFK DLILRMLDYD 
       473        483 
PKTRIQPYYA LQHSFFKkta de
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X321