8YEV

DYRK1A (Dual specificity tyrosine-phosphorylation-regulated kinase 1A)
Group: CMGC
Uniprot: DYR1A_HUMAN
Organism: Homo sapiens
Domain boundary: 159 - 479
Resolu: 2.252

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in CUE Type1 135 - 480 0
B Active DFGin BLAminus in-in in-in CUE Type1 135 - 480 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       142        152        162        172 
mkVYNDGYDD DNYDYIVKNG EKWMDRYEID SLIGKGSFGQ 
       182        192        202        212 
VVKAYDRVEQ EWVAIKIIKN KKAFLNQAQI EVRLLELMNK 
       222        232        242        252 
HdtemkYYIV HLKRHFMFRN HLCLVFEMLS YNLYDLLRNT 
       262        272        282        292 
NFRGVSLNLT RKFAQQMCTA LLFLATPELS IIHCDLKPEN 
       302        312        322        332 
ILLCNPKRSA IKIVDFGSSC QLGQRIYQYI QSRFYRSPEV 
       342        352        362        372 
LLGMPYDLAI DMWSLGCILV EMHTGEPLFS GANEVDQMNK 
       382        392        402        412 
IVEVLGIPPA HILDQAPKAR KFFEKLPDGT WNLKKTKDGK 
       422        432        442        452 
REYKPPGTRK LHNILGVETG GPGGRRAGES GHTVADYLKF 
       462        472          -          - 
KDLILRMLDY DPKTRIQPYY ALQHSFFKkg aahhhhhhhh


Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X321