CAMK_CHEK2 (Serine/threonine-protein kinase Chk2)

Total number of chains: 46
Active chains: 2
Uniprot: CHK2_HUMAN
Kinase Domain Residues: 220 - 486
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 40 87.0% AF-O96017-K1A
DFGin None 5 10.9% 3I6UB
DFGin BLAplus 1 2.2% 3I6UA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-O96017-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 212 - 494 0 None None Serine/threonine-protein kinase Chk2
AF-O96017-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 212 - 494 0 None None Serine/threonine-protein kinase Chk2
2CN5A 2.25 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaooi APEdist_oooo ADP ATPlike 209 - 504 0 None None Serine/threonine-protein kinase Chk2
2XK9A 2.35 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo XK9 Type1 211 - 510 0 None None Serine/threonine-protein kinase Chk2
2YCFA 1.77 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oooo YCF Type1 210 - 510 0 None None Serine/threonine-protein kinase Chk2
2W0JA 2.05 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaooi APEdist_oooo ZAT Type1 210 - 510 0 None None Serine/threonine-protein kinase Chk2
2W7XA 2.07 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo D1A Type1 210 - 510 0 None None Serine/threonine-protein kinase Chk2
2YCQA 2.05 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_oooo UPX Type1 211 - 510 0 None None Serine/threonine-protein kinase Chk2
2YCSA 2.35 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo NXP Type1 210 - 510 0 None None Serine/threonine-protein kinase Chk2
2YIQA 1.89 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo YIQ Type1 211 - 510 0 None None Serine/threonine-protein kinase Chk2
2YIRA 2.1 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_oooo YIR Type1 210 - 509 0 None None Serine/threonine-protein kinase Chk2
2YCRA 2.2 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo HCW Type1 211 - 510 0 None None Serine/threonine-protein kinase Chk2
2CN8A 2.7 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aannn APEdist_ooon DBQ Type1 212 - 503 0 None None Serine/threonine-protein kinase Chk2
2WTCA 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oooo VGM Type1 211 - 512 0 None None Serine/threonine-protein kinase Chk2
2WTDA 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaino APEdist_oooo ZZK Type1 210 - 512 0 None None Serine/threonine-protein kinase Chk2
2WTIA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo WTI Type1 210 - 512 0 None None Serine/threonine-protein kinase Chk2
2WTJA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oooo WTJ Type1 209 - 512 0 None None Serine/threonine-protein kinase Chk2
2XBJA 2.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oooo XBJ Type1 211 - 512 0 None None Serine/threonine-protein kinase Chk2
2XM8A 3.4 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aannn APEdist_oooo B4W Type1 211 - 503 0 None None Serine/threonine-protein kinase Chk2
2XM9A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo LWH Type1 211 - 512 0 None None Serine/threonine-protein kinase Chk2
4A9RA 2.85 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo RU5 Type1 210 - 513 0 None None Serine/threonine-protein kinase Chk2
4A9SA 2.66 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo RU9 Type1 211 - 513 0 None None Serine/threonine-protein kinase Chk2
4A9TA 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo A9T Type1 210 - 513 0 None None Serine/threonine-protein kinase Chk2
4A9UA 2.48 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo A9U Type1 210 - 513 0 None None Serine/threonine-protein kinase Chk2
4BDAA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaini APEdist_oooo VFB Type1 210 - 512 0 None None Serine/threonine-protein kinase Chk2
4BDBA 2.5 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaini APEdist_oooo ODO Type1 210 - 513 0 None None Serine/threonine-protein kinase Chk2
4BDCA 3.0 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_oooo ODH Type1 210 - 512 0 None None Serine/threonine-protein kinase Chk2
4BDDA 2.67 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaini APEdist_oooo Z0O Type1 210 - 512 0 None None Serine/threonine-protein kinase Chk2
4BDEA 2.55 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaioi APEdist_oooo CWS Type1 210 - 513 0 None None Serine/threonine-protein kinase Chk2
4BDFA 2.7 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaioi APEdist_oooo H3R Type1 210 - 512 0 None None Serine/threonine-protein kinase Chk2
4BDGA 2.84 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaini APEdist_oooo P3J Type1 210 - 512 0 None None Serine/threonine-protein kinase Chk2
4BDHA 2.7 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaini APEdist_oooo WVI Type1 210 - 513 0 None None Serine/threonine-protein kinase Chk2
4BDIA 2.32 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaioi APEdist_oooo HAU Type1 210 - 515 0 None None Serine/threonine-protein kinase Chk2
4BDJA 3.01 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_oooo Z2M Type1 211 - 513 0 None None Serine/threonine-protein kinase Chk2
4BDKA 3.3 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaioo APEdist_oooo RQQ Type1 211 - 513 0 None None Serine/threonine-protein kinase Chk2
2YITA 2.2 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo YIT Type1.5_Back 211 - 510 0 None None Serine/threonine-protein kinase Chk2
3I6UA 3.0 Inactive DFGin‑BLAplus out-none out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 89 - 501 0 None K249R Serine/threonine-protein kinase Chk2
3I6UB 3.0 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 89 - 501 0 None K249R Serine/threonine-protein kinase Chk2
3I6WA 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2
3I6WC 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2
3I6WE 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2
3I6WG 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2
3I6WB 3.25 None DFGin‑BLAminus out-none in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2
3I6WD 3.25 None DFGin‑BLAminus out-none in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2
3I6WF 3.25 None DFGin‑BLAminus out-none in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2
3I6WH 3.25 None DFGin‑BLAminus out-none in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2

CAMK_CHEK2 (Serine/threonine-protein kinase Chk2)

Total number of chains: 46
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 40 87.0% AF-O96017-K1A
DFGin None 5 10.9% 3I6UB
DFGin BLAplus 1 2.2% 3I6UA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CHK2_HUMAN AF-O96017-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 212 - 494 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN AF-O96017-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 212 - 494 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2CN5A 2.25 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaooi APEdist_oooo ADP ATPlike 209 - 504 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2XK9A 2.35 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo XK9 Type1 211 - 510 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2YCFA 1.77 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oooo YCF Type1 210 - 510 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2W0JA 2.05 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaooi APEdist_oooo ZAT Type1 210 - 510 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2W7XA 2.07 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo D1A Type1 210 - 510 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2YCQA 2.05 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_oooo UPX Type1 211 - 510 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2YCSA 2.35 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo NXP Type1 210 - 510 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2YIQA 1.89 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo YIQ Type1 211 - 510 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2YIRA 2.1 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_oooo YIR Type1 210 - 509 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2YCRA 2.2 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo HCW Type1 211 - 510 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2CN8A 2.7 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aannn APEdist_ooon DBQ Type1 212 - 503 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2WTCA 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oooo VGM Type1 211 - 512 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2WTDA 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaino APEdist_oooo ZZK Type1 210 - 512 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2WTIA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo WTI Type1 210 - 512 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2WTJA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oooo WTJ Type1 209 - 512 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2XBJA 2.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oooo XBJ Type1 211 - 512 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2XM8A 3.4 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aannn APEdist_oooo B4W Type1 211 - 503 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2XM9A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo LWH Type1 211 - 512 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4A9RA 2.85 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo RU5 Type1 210 - 513 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4A9SA 2.66 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo RU9 Type1 211 - 513 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4A9TA 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo A9T Type1 210 - 513 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4A9UA 2.48 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo A9U Type1 210 - 513 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4BDAA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaini APEdist_oooo VFB Type1 210 - 512 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4BDBA 2.5 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaini APEdist_oooo ODO Type1 210 - 513 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4BDCA 3.0 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_oooo ODH Type1 210 - 512 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4BDDA 2.67 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaini APEdist_oooo Z0O Type1 210 - 512 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4BDEA 2.55 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaioi APEdist_oooo CWS Type1 210 - 513 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4BDFA 2.7 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaioi APEdist_oooo H3R Type1 210 - 512 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4BDGA 2.84 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaini APEdist_oooo P3J Type1 210 - 512 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4BDHA 2.7 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaini APEdist_oooo WVI Type1 210 - 513 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4BDIA 2.32 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaioi APEdist_oooo HAU Type1 210 - 515 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4BDJA 3.01 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_oooo Z2M Type1 211 - 513 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 4BDKA 3.3 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaioo APEdist_oooo RQQ Type1 211 - 513 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 2YITA 2.2 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo YIT Type1.5_Back 211 - 510 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 3I6UA 3.0 Inactive DFGin‑BLAplus out-none out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 89 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 3I6UB 3.0 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 89 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 3I6WA 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 3I6WC 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 3I6WE 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 3I6WG 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 3I6WB 3.25 None DFGin‑BLAminus out-none in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 3I6WD 3.25 None DFGin‑BLAminus out-none in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 3I6WF 3.25 None DFGin‑BLAminus out-none in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens
CHK2_HUMAN 3I6WH 3.25 None DFGin‑BLAminus out-none in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens

CAMK_CHEK2 (Serine/threonine-protein kinase Chk2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism