8A8M

MAP2K6 (Dual specificity mitogen-activated protein kinase kinase 6)
MAPK14 (Mitogen-activated protein kinase 14)
Group: STE CMGC
Uniprot: MK14_HUMAN MP2K6_HUMAN
Organism: Homo sapiens
Domain boundary: 53 - 314 24 - 308
Resolution: 4.0

Chain id Group Gene UniprotID Protein Organism Activity Spatial Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
B STE MAP2K6 MP2K6_HUMAN Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens None DFGin BLAminus in-out in-none AP2 Type1 38 - 334 13
A CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 Homo sapiens Inactive None None in-out out-out AP2 Type1 5 - 353 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
         -          -          9         19 
mgsshhhhhh ssglevlfqg pmsqeRPTFY RQELNKTIWE 
        29         39         49         59 
VPERYQNLSP VGSGAYGSVC AAFDTKTGLR VAVKKLSRPF 
        69         79         89         99 
QSIIHAKRTY RELRLLKHMK HENVIGLLDV FTPARSLEEF 
       109        119        129        139 
NDVYLVTHLM GADLNNIVKC QKLTDDHVQF LIYQILRGLK 
       149        159        169        179 
YIHSADIIHR DLKPSNLAVN EDCELKILDF GLARHTDDEM 
       189        199        209        219 
VGYVATRWYR APEIMLNWMH YNQTVDIWSV GCIMAELLTG 
       229        239        249        259 
RTLFPGTDHI DQLKLILRLV GTPGAELLKK ISSESARNYI 
       269        279        289        299 
QSLTQMPKMN FANVFIGANP LAVDLLEKML VLDSDKRITA 
       309        319        329        339 
AQALAHAYFA QYHDPDDEPV ADPYDQSFES RDLLIDEWKS 
       349        359 
LTYDEVISFV PPPLdqeeme s
Lower-case residues are disordered in structure.
Mutations: T180V
Phosphorylation: None