MAP2K6 (Dual specificity mitogen-activated protein kinase kinase 6)

Group: STE
Uniprot: MP2K6_HUMAN
Domain boundary: 53 - 314


Total number of chains: 14
Spatial Dihedral Chains Representative
DFGin BLAminus 2 AF-P52564-K1A
DFGin None 4 3ENMA
DFGout None 6 8P7JB
None None 2 3VN9A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P52564-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 45 - 322 None None 0
8A8MB 4.0 None DFGin BLAminus in-out in-none AP2 Type1 38 - 334 S207D,T211D None 13
3ENMA 2.35 Inactive DFGin None out-out out-none No_ligand No_ligand 46 - 332 S207D,T211D None 9
3ENMB 2.35 Inactive DFGin None out-out out-none No_ligand No_ligand 49 - 332 S207D,T211D None 8
3ENMC 2.35 Inactive DFGin None out-out out-none No_ligand No_ligand 48 - 332 S207D,T211D None 8
3ENMD 2.35 Inactive DFGin None out-out out-none No_ligand No_ligand 45 - 332 S207D,T211D None 9
8P7JA 2.4 Inactive DFGout None in-out out-none X3K Type1 47 - 333 S207D,T211D None 12
8P7JB 2.4 Inactive DFGout None out-out out-none X3K Type1 47 - 333 S207D,T211D None 10
8PM3A 2.0 Inactive DFGout None out-out out-none ZLE Type1 47 - 333 S207D,T211D None 10
8PM3B 2.0 Inactive DFGout None out-out out-none ZLE Type1 47 - 333 S207D,T211D None 10
8PM3C 2.0 Inactive DFGout None out-out out-none ZLE Type1 47 - 333 S207D,T211D None 11
8PM3D 2.0 Inactive DFGout None out-out out-none ZLE Type1 47 - 333 S207D,T211D None 11
3FMEA 2.26 Inactive None None out-out none-out STU Type1 47 - 333 S207D,T211D None 15
3VN9A 2.6 Inactive None None out-out out-out ANK Type1 44 - 334 None None 0

MAP2K6 (Dual specificity mitogen-activated protein kinase kinase 6)

Group: STE
Total number of chains: 14
Spatial Dihedral Chains Representative
DFGin BLAminus 2 AF-P52564-K1A
DFGin None 4 3ENMA
DFGout None 6 8P7JB
None None 2 3VN9A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens MP2K6_HUMAN AF-P52564-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 45 - 322 None None 0
Homo sapiens MP2K6_HUMAN 8A8MB 4.0 None DFGin BLAminus in-out in-none AP2 Type1 38 - 334 S207D,T211D None 13
Homo sapiens MP2K6_HUMAN 3ENMA 2.35 Inactive DFGin None out-out out-none No_ligand No_ligand 46 - 332 S207D,T211D None 9
Homo sapiens MP2K6_HUMAN 3ENMB 2.35 Inactive DFGin None out-out out-none No_ligand No_ligand 49 - 332 S207D,T211D None 8
Homo sapiens MP2K6_HUMAN 3ENMC 2.35 Inactive DFGin None out-out out-none No_ligand No_ligand 48 - 332 S207D,T211D None 8
Homo sapiens MP2K6_HUMAN 3ENMD 2.35 Inactive DFGin None out-out out-none No_ligand No_ligand 45 - 332 S207D,T211D None 9
Homo sapiens MP2K6_HUMAN 8P7JA 2.4 Inactive DFGout None in-out out-none X3K Type1 47 - 333 S207D,T211D None 12
Homo sapiens MP2K6_HUMAN 8P7JB 2.4 Inactive DFGout None out-out out-none X3K Type1 47 - 333 S207D,T211D None 10
Homo sapiens MP2K6_HUMAN 8PM3A 2.0 Inactive DFGout None out-out out-none ZLE Type1 47 - 333 S207D,T211D None 10
Homo sapiens MP2K6_HUMAN 8PM3B 2.0 Inactive DFGout None out-out out-none ZLE Type1 47 - 333 S207D,T211D None 10
Homo sapiens MP2K6_HUMAN 8PM3C 2.0 Inactive DFGout None out-out out-none ZLE Type1 47 - 333 S207D,T211D None 11
Homo sapiens MP2K6_HUMAN 8PM3D 2.0 Inactive DFGout None out-out out-none ZLE Type1 47 - 333 S207D,T211D None 11
Homo sapiens MP2K6_HUMAN 3FMEA 2.26 Inactive None None out-out none-out STU Type1 47 - 333 S207D,T211D None 15
Homo sapiens MP2K6_HUMAN 3VN9A 2.6 Inactive None None out-out out-out ANK Type1 44 - 334 None None 0

MAP2K6 (Dual specificity mitogen-activated protein kinase kinase 6)

No non-human structures known.