5CSW

BRAF (Serine/threonine-protein kinase B-raf)
Group: TKL
Uniprot: BRAF_HUMAN
Organism: Homo sapiens
Domain boundary: 457 - 716
Resolu: 2.66

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None out-out none-out P06 Type1.5_Back 449 - 721 19
B Inactive DFGin BLBminus out-out none-none P06 Type1.5_Back 447 - 721 18
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       451        461        471        481 
gprdsSDDWE IPDGQITVGQ RIGSGSFGTV YKGKWHGDVA 
       491        501        511        521 
VKMLNVTAPT PQQLQAFKNE VGVLRKTRHV NILLFMGYST 
       531        541        551        561 
KPQLAIVTQW CEGSSLYHHL HASETKFEMK KLIDIARQTA 
       571        581        591        601 
RGMDYLHAKS IIHRDLKSNN IFLHEDNTVK IGDFGLatvk 
       611        621        631        641 
srwsgshqfe qlsgSILWMA PEVIRmqdsn PYSFQSDVYA 
       651        661        671        681 
FGIVLYELMT GQLPYSNINN RDQIIEMVGR GSLSPDLSKV 
       691        701        711        721 
RSNCPKRMKR LMAECLKKKR DERPSFPRIL AEIEELAREL 

sg
Lower-case residues are disordered in structure.
Mutations: R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E
Phosphorylation: None