4XV2

BRAF (Serine/threonine-protein kinase B-raf)
Group: TKL
Uniprot: BRAF_HUMAN
Organism: Homo sapiens
Domain boundary: 457 - 716
Resolu: 2.5

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLBminus out-out none-out P06 Type1.5_Back 449 - 705 18
B Inactive DFGin BLBminus in-out none-out P06 Type1.5_Back 448 - 705 18
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
         -        451        461        471 
mkkghhhhhh gsrdaaDDWE IPDGQITVGQ RIGSGSFGTV 
       481        491        501        511 
YKGKWHGDVA VKMLNVTAPT PQQLQAFKNE VGVLRKTRHV 
       521        531        541        551 
NILLFMGYST KPQLAIVTQW CEGSSLYHHL HASEtkFEMK 
       561        571        581        591 
KLIDIARQTA RGMDYLHAKS IIHRDLKSNN IFLHEDNTVK 
       601        611        621        631 
IGDFGlatek srwsgshqfe qlsGSILWMA PEVIRmqdsN 
       641        651        661        671 
PYSFQSDVYA FGIVLYELMT GQLPYSNINN RDQIIEMVGR 
       681        691        701          - 
GSLSPDLSKV RSNCPKRMKR LMAECLKKKR DERPSFPRIL 
         - 
AEIEELAREl sg
Lower-case residues are disordered in structure.
Mutations: S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R
Phosphorylation: None