4PL3

ERN1 (Serine/threonine-protein kinase/endoribonuclease IRE1)
Group: OTHER
Uniprot: ERN1_MOUSE
Organism: Mus musculus
Domain boundary: 569 - 832
Resolu: 2.9

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLBplus out-out out-in 31J ADP Allosteric Type1 560 - 964 12
B Inactive DFGin BLBplus out-out out-in 31J ADP Allosteric Type1 562 - 963 13
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       552        562        572        582 
gamdpefpsl eqddedeetR MVIVGKISFC PKDVLGHGAE 
       592        602        612        622 
GTIVYKGMFD NRDVAVKRIL PECFSFADRE VQLLRESDEH 
       632        642        652        662 
PNVIRYFCTE KDRQFQYIAI ELCAATLQEY VEQKDFAHLG 
       672        682        692        702 
LEPITLLHQT TSGLAHLHSL NIVHRDLKPH NILLSMPNAH 
       712        722        732        742 
GRIKAMISDF GLCKKlavgr hsfsrrsgVP GTEGWIAPEM 
       752        762        772        782 
LSedckdnPT YTVDIFSAGC VFYYVISEGY HPFGKSLQRQ 
       792        802        812        822 
ANILLGACNL DCFHSDKHED VIARELIEKM IAMDPQQRPS 
       832        842        852        862 
AKHVLKHPFF WSLEKQLQFF QDVSDRIEKE ALDGPIVRQL 
       872        882        892        902 
ERGGRAVVKM DWRENITVPL QTDLRKFRTY KGGSVRDLLR 
       912        922        932        942 
AMRNKKHHYR ELPVEVQETL GSIPDDFVRY FTSRFPHLLS 
       952        962        972 
HTYQAMELCR HERLFQTYYW Heptepqppv ipyal
Lower-case residues are disordered in structure.
Mutations: N772Y
Phosphorylation: None