WNK1 (Serine/threonine-protein kinase WNK1)

Group: OTHER
Uniprot: WNK1_HUMAN
Domain boundary: 220 - 479


Total number of chains: 8
Spatial Dihedral Chains Representative
DFGin BLAminus 7 AF-Q9H4A3-K1A
DFGin None 1 4PWNA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q9H4A3-K1A -1.0 Active DFGin BLAminus out-none in-in No_ligand No_ligand 212 - 487 None None 0
5WDYA 2.458 None DFGin BLAminus out-none in-none ANP A6S Type1 Type3 208 - 481 S378D,E396A,E397A,K398A None 9
5WDYB 2.458 None DFGin BLAminus out-none in-none ANP A6S Type1 Type3 206 - 480 S378D,E396A,E397A,K398A None 9
5WE8A 2.006 Inactive DFGin BLAminus out-none in-out ANP A7Y Type1 Type3 209 - 483 S378D,E396A,E397A,K398A None 0
5WE8B 2.006 Inactive DFGin BLAminus out-none in-out ANP A7Y Type1 Type3 207 - 480 S378D,E396A,E397A,K398A None 0
5TF9A 2.5 Inactive DFGin BLAminus out-none in-out 7AV ANP Type3 Type1 210 - 483 None None 9
5TF9B 2.5 Inactive DFGin BLAminus out-none in-out 7AV ANP Type3 Type1 206 - 480 None None 9
4PWNA 1.84 Inactive DFGin None out-none out-none No_ligand No_ligand 210 - 482 None None 13

WNK1 (Serine/threonine-protein kinase WNK1)

Group: OTHER
Total number of chains: 16
Spatial Dihedral Chains Representative
DFGin BLAminus 9 AF-Q9H4A3-K1A
DFGin BLBminus 3 6CN9B
DFGin BLBtrans 3 5DRBA
DFGin None 1 4PWNA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens WNK1_HUMAN AF-Q9H4A3-K1A -1.0 Active DFGin BLAminus out-none in-in No_ligand No_ligand 212 - 487 None None 0
Homo sapiens WNK1_HUMAN 5WDYA 2.458 None DFGin BLAminus out-none in-none ANP A6S Type1 Type3 208 - 481 S378D,E396A,E397A,K398A None 9
Homo sapiens WNK1_HUMAN 5WDYB 2.458 None DFGin BLAminus out-none in-none ANP A6S Type1 Type3 206 - 480 S378D,E396A,E397A,K398A None 9
Homo sapiens WNK1_HUMAN 5WE8A 2.006 Inactive DFGin BLAminus out-none in-out ANP A7Y Type1 Type3 209 - 483 S378D,E396A,E397A,K398A None 0
Homo sapiens WNK1_HUMAN 5WE8B 2.006 Inactive DFGin BLAminus out-none in-out ANP A7Y Type1 Type3 207 - 480 S378D,E396A,E397A,K398A None 0
Homo sapiens WNK1_HUMAN 5TF9A 2.5 Inactive DFGin BLAminus out-none in-out 7AV ANP Type3 Type1 210 - 483 None None 9
Homo sapiens WNK1_HUMAN 5TF9B 2.5 Inactive DFGin BLAminus out-none in-out 7AV ANP Type3 Type1 206 - 480 None None 9
Homo sapiens WNK1_HUMAN 4PWNA 1.84 Inactive DFGin None out-none out-none No_ligand No_ligand 210 - 482 None None 13
Rattus norvegicus WNK1_RAT 6CN9A 1.8 Inactive DFGin BLAminus out-none out-out No_ligand No_ligand 210 - 480 None None 0
Rattus norvegicus WNK1_RAT 4Q2AA 3.5 Inactive DFGin BLAminus out-none out-out No_ligand No_ligand 210 - 480 S382A None 0
Rattus norvegicus WNK1_RAT 6CN9B 1.8 Inactive DFGin BLBminus out-none out-out No_ligand No_ligand 210 - 481 None None 0
Rattus norvegicus WNK1_RAT 7UOSA 2.9 Inactive DFGin BLBminus out-none out-out WIB Type1 211 - 481 S382A None 0
Rattus norvegicus WNK1_RAT 6OL2A 2.1 Inactive DFGin BLBminus out-none out-out MU7 Type1.5_Back 203 - 481 S382A None 0
Rattus norvegicus WNK1_RAT 5W7TA 2.01 Inactive DFGin BLBtrans out-none out-in ANP Type1 210 - 482 None X382 0
Rattus norvegicus WNK1_RAT 5W7TB 2.01 Inactive DFGin BLBtrans out-none out-in ANP Type1 210 - 482 None X382 0
Rattus norvegicus WNK1_RAT 5DRBA 1.65 Inactive DFGin BLBtrans out-none out-out 5FJ Type1.5_Front 209 - 481 S382A None 0

WNK1 (Serine/threonine-protein kinase WNK1)

Group: OTHER
Total number of chains: 8
Spatial Dihedral Chains Representative
DFGin BLAminus 2 6CN9A
DFGin BLBminus 3 6CN9B
DFGin BLBtrans 3 5DRBA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Rattus norvegicus WNK1_RAT 6CN9A 1.8 Inactive DFGin BLAminus out-none out-out No_ligand No_ligand 210 - 480 None None 0
Rattus norvegicus WNK1_RAT 4Q2AA 3.5 Inactive DFGin BLAminus out-none out-out No_ligand No_ligand 210 - 480 S382A None 0
Rattus norvegicus WNK1_RAT 6CN9B 1.8 Inactive DFGin BLBminus out-none out-out No_ligand No_ligand 210 - 481 None None 0
Rattus norvegicus WNK1_RAT 7UOSA 2.9 Inactive DFGin BLBminus out-none out-out WIB Type1 211 - 481 S382A None 0
Rattus norvegicus WNK1_RAT 6OL2A 2.1 Inactive DFGin BLBminus out-none out-out MU7 Type1.5_Back 203 - 481 S382A None 0
Rattus norvegicus WNK1_RAT 5W7TA 2.01 Inactive DFGin BLBtrans out-none out-in ANP Type1 210 - 482 None X382 0
Rattus norvegicus WNK1_RAT 5W7TB 2.01 Inactive DFGin BLBtrans out-none out-in ANP Type1 210 - 482 None X382 0
Rattus norvegicus WNK1_RAT 5DRBA 1.65 Inactive DFGin BLBtrans out-none out-out 5FJ Type1.5_Front 209 - 481 S382A None 0