8R4O

SIK3 (Serine/threonine-protein kinase SIK3)
Group: CAMK
Uniprot: SIK3_HUMAN
Organism: Homo sapiens
Domain boundary: 66 - 317
Resolu: 2.725

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 0
C Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 0
E Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 0
G Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 0
I Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 0
K Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain K
        67         77         87         97 
smpaRIGYYE IDRTIGKGNF AVVKRATHLV TKAKVAIKII 
       107        117        127        137 
DKTQLDEENL KKIFREVQIM KMLSHPHIIR LYQVMETERM 
       147        157        167        177 
IYLVTEYASG GEIFDHLVAH GRMAEKEARR KFKQIVTAVY 
       187        197        207        217 
FCHSRNIVHR DLKAENLLLD ANLNIKIADF GFSNLFTPGQ 
       227        237        247        257 
LLKTWCGSPP YAAPELFEGK EYDGPKVDIW SLGVVLYVLV 
       267        277        287        297 
CGALPFDGST LQNLRARVLS GKFRIPFFMS TECEHLIRHM 
       307        317        327        337 
LVLDPNKRLS MEQICKHKWM KLGDADPNFD RLIAESQQLk 
       347        357        367        377 
eerqvdPLNE DVLLAMEDMG LDKEQTLQSL RSDAYDHYSA 

IYSLLCDr
Lower-case residues are disordered in structure.
Mutations: C121S,C181S,C333S
Phosphorylation: X221