ROS1 (Proto-oncogene tyrosine-protein kinase ROS)

Group: TYR
Uniprot: ROS1_HUMAN
Domain boundary: 1945 - 2217


Total number of chains: 7
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-P08922-K1A
DFGin ABAminus 2 4UXLA
DFGin None 4 7Z5WA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
3ZBFA 2.2 Inactive DFGin ABAminus in-in in-out VGH Type1 1934 - 2230 None None 12
4UXLA 2.4 Inactive DFGin ABAminus in-out in-out 5P8 Type1 1934 - 2230 None None 8
AF-P08922-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1937 - 2225 None None 0
7Z5WA 2.254 Inactive DFGin None in-out none-out IDW Type1 1937 - 2225 None None 18
7Z5WB 2.254 Inactive DFGin None in-out none-out IDW Type1 1937 - 2226 None None 18
7Z5XA 2.035 Inactive DFGin None in-in none-out AWJ Type1 1937 - 2225 None None 19
7Z5XB 2.035 Inactive DFGin None in-in none-out AWJ Type1 1937 - 2226 None None 19

ROS1 (Proto-oncogene tyrosine-protein kinase ROS)

Group: TYR
Total number of chains: 7
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-P08922-K1A
DFGin ABAminus 2 4UXLA
DFGin None 4 7Z5WA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens ROS1_HUMAN 3ZBFA 2.2 Inactive DFGin ABAminus in-in in-out VGH Type1 1934 - 2230 None None 12
Homo sapiens ROS1_HUMAN 4UXLA 2.4 Inactive DFGin ABAminus in-out in-out 5P8 Type1 1934 - 2230 None None 8
Homo sapiens ROS1_HUMAN AF-P08922-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1937 - 2225 None None 0
Homo sapiens ROS1_HUMAN 7Z5WA 2.254 Inactive DFGin None in-out none-out IDW Type1 1937 - 2225 None None 18
Homo sapiens ROS1_HUMAN 7Z5WB 2.254 Inactive DFGin None in-out none-out IDW Type1 1937 - 2226 None None 18
Homo sapiens ROS1_HUMAN 7Z5XA 2.035 Inactive DFGin None in-in none-out AWJ Type1 1937 - 2225 None None 19
Homo sapiens ROS1_HUMAN 7Z5XB 2.035 Inactive DFGin None in-in none-out AWJ Type1 1937 - 2226 None None 19

ROS1 (Proto-oncogene tyrosine-protein kinase ROS)

No non-human structures known.