AF-P08922-K1

ROS1 (Proto-oncogene tyrosine-protein kinase ROS)
Group: TYR
Uniprot: ROS1_HUMAN
Organism: Homo sapiens
Domain boundary: 1945 - 2217
Resolu: -1.0

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in No_ligand No_ligand 1937 - 2225 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
      1946       1956       1966       1976 
LPAFPREKLT LRLLLGSGAF GEVYEGTAVD ILGVGSGEIK 
      1986       1996       2006       2016 
VAVKTLKKGS TDQEKIEFLK EAHLMSKFNH PNILKQLGVC 
      2026       2036       2046       2056 
LLNEPQYIIL ELMEGGDLLT YLRKARMATF YGPLLTLVDL 
      2066       2076       2086       2096 
VDLCVDISKG CVYLERMHFI HRDLAARNCL VSVKDYTSPR 
      2106       2116       2126       2136 
IVKIGDFGLA RDIYKNDYYR KRGEGLLPVR WMAPESLMDG 
      2146       2156       2166       2176 
IFTTQSDVWS FGILIWEILT LGHQPYPAHS NLDVLNYVQT 
      2186       2196       2206       2216 
GGRLEPPRNC PDDLWNLMTQ CWAQEPDQRP TFHRIQDQLQ 

LFRNFFLNS
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None