PAK1 (Serine/threonine-protein kinase PAK 1)

Group: STE
Uniprot: PAK1_HUMAN
Domain boundary: 270 - 521


Total number of chains: 52
Spatial Dihedral Chains Representative
DFGin BLAminus 28 AF-Q13153-K1A
DFGin BLAplus 3 1F3MC
DFGin BLBplus 4 4ZY5B
DFGin None 5 5DEYB
DFGout BBAminus 8 4ZJID
DFGout None 1 4ZLOA
None None 3 5KBQB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q13153-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 262 - 529 None None 0
4ZLOB 2.5 None DFGin BLAminus out-none in-in No_ligand No_ligand 253 - 543 None X423 0
3Q52A 1.801 None DFGin BLAminus out-none in-in No_ligand No_ligand 250 - 542 K299R,L516I X423 0
1YHWA 1.8 None DFGin BLAminus out-none in-in No_ligand No_ligand 249 - 541 K299R None 0
8X5ZA 1.8 None DFGin BLAminus out-none in-in No_ligand No_ligand 249 - 543 K299R,E503D X423 0
1YHVA 1.8 None DFGin BLAminus out-none in-in No_ligand No_ligand 249 - 541 K299R,T423E None 0
4O0RB 2.4 None DFGin BLAminus out-out none-out No_ligand No_ligand 249 - 542 None None 8
3FXZA 1.64 None DFGin BLAminus out-none in-in FLL Type1 249 - 541 K299R X423 0
3FY0A 2.35 None DFGin BLAminus out-none in-in DW1 Type1 249 - 541 K299R X423 0
4DAWA 2.0 None DFGin BLAminus in-none in-in 0H2 Type1 249 - 542 K299R X423 0
3Q53A 2.09 None DFGin BLAminus out-none in-in ATP Type1 250 - 541 K299R,L516I X423 0
4ZY4A 2.6 Active DFGin BLAminus in-in in-in 4T3 Type1 249 - 541 D389N None 0
4ZY5A 2.35 Active DFGin BLAminus in-in in-in 4T5 Type1 251 - 542 None None 0
4ZY6A 2.15 Active DFGin BLAminus in-in in-in 4T6 Type1 251 - 542 D389N None 0
6B16A 2.285 Inactive DFGin BLAminus out-out in-in C7Y Type1 251 - 542 None None 0
7VTOA 2.59 Inactive DFGin BLAminus out-out in-in 107 Type1 257 - 542 None X423 0
2HY81 2.0 None DFGin BLAminus in-none in-in 1ST Type1 249 - 541 K299R,T423E None 0
5DEWA 1.9 Inactive DFGin BLAminus out-out in-in 59N Type1 250 - 544 D389N,T423E None 0
4O0RA 2.4 Inactive DFGin BLAminus out-out in-in 7KC Type1 249 - 541 None None 0
5KBQA 2.58 Inactive DFGin BLAminus out-out in-in IPV Type1 254 - 542 D389N,T423E,E503D None 0
5KBRA 2.36 Inactive DFGin BLAminus in-out in-in IPW Type1 255 - 542 D389N,T423E,E503D None 7
4P90A 2.49 Inactive DFGin BLAminus out-out in-in 2K0 Type1 250 - 542 D389N,T423E,E503D None 5
3Q4ZA 1.887 None DFGin BLAminus out-none in-in ANP Type1 251 - 545 S259I,K299R,D389N,L516I None 0
4EQCA 2.01 None DFGin BLAminus out-none in-in XR1 Type1.5_Back 249 - 541 K299R X423 0
5DEYA 2.1 Inactive DFGin BLAminus out-out in-in 59T Type1.5_Back 250 - 544 D389N,T423E None 0
4O0TA 2.6 Active DFGin BLAminus in-in in-in 2OL Type1.5_Back 251 - 542 None None 0
5IMEA 2.217 Inactive DFGin BLAminus out-out in-in 6BZ Type1.5_Back 251 - 545 None None 0
5DFPA 2.2 None DFGin BLAminus out-none in-in 59U Type1.5_Front 249 - 541 K299R X423 0
1F3MC 2.3 Inactive DFGin BLAplus out-none out-out No_ligand No_ligand 249 - 542 None None 7
1F3MD 2.3 Inactive DFGin BLAplus out-none out-out No_ligand No_ligand 249 - 542 None None 9
4ZY6B 2.15 Inactive DFGin BLAplus out-out none-out 4T6 Type1 255 - 542 D389N None 8
4ZY4B 2.6 Inactive DFGin BLBplus out-out out-out 4T3 Type1 249 - 541 D389N None 0
4ZY5B 2.35 Inactive DFGin BLBplus out-out out-out 4T5 Type1 255 - 542 None None 0
6B16B 2.285 Inactive DFGin BLBplus out-out none-out C7Y Type1 255 - 542 None None 7
5DEWB 1.9 Inactive DFGin BLBplus out-out none-out 59N Type1 255 - 542 D389N,T423E None 7
4O0TB 2.6 Inactive DFGin None out-out none-out No_ligand No_ligand 255 - 542 None None 8
3Q4ZB 1.887 Inactive DFGin None out-none none-out No_ligand No_ligand 250 - 541 S259I,K299R,D389N,L516I None 9
7VTOB 2.59 Inactive DFGin None out-out none-out 107 Type1 255 - 542 None X423 10
5DEYB 2.1 Inactive DFGin None out-out none-out 59T Type1 255 - 542 D389N,T423E None 7
5IMEB 2.217 Inactive DFGin None out-out none-out 6BZ Type1 250 - 541 None None 8
4ZJIA 1.99 Inactive DFGout BBAminus out-out out-in 4OQ Type3 254 - 542 None None 6
4ZJIB 1.99 Inactive DFGout BBAminus out-out out-in 4OQ Type3 254 - 540 None None 6
4ZJIC 1.99 Inactive DFGout BBAminus out-out out-out 4OQ Type3 250 - 541 None None 5
4ZJID 1.99 Inactive DFGout BBAminus out-out in-out 4OQ Type3 253 - 541 None None 4
4ZJJA 2.2 Inactive DFGout BBAminus out-out out-in 4OR Type3 249 - 539 None None 7
4ZJJB 2.2 Inactive DFGout BBAminus out-out out-in 4OR Type3 251 - 539 None None 7
4ZJJC 2.2 Inactive DFGout BBAminus out-none none-out 4OR Type3 251 - 542 None None 7
4ZJJD 2.2 Inactive DFGout BBAminus out-none none-out 4OR Type3 252 - 541 None None 4
4ZLOA 2.5 Inactive DFGout None out-out none-out 4PV Type3 250 - 543 None X423 9
5KBQB 2.58 Inactive None None out-out none-out No_ligand No_ligand 255 - 542 D389N,T423E,E503D None 11
5KBRB 2.36 Inactive None None out-out none-out IPW Type1 255 - 542 D389N,T423E,E503D None 11
4P90B 2.49 Inactive None None out-out none-out 2K0 Type1 257 - 542 D389N,T423E,E503D None 11

PAK1 (Serine/threonine-protein kinase PAK 1)

Group: STE
Total number of chains: 52
Spatial Dihedral Chains Representative
DFGin BLAminus 28 AF-Q13153-K1A
DFGin BLAplus 3 1F3MC
DFGin BLBplus 4 4ZY5B
DFGin None 5 5DEYB
DFGout BBAminus 8 4ZJID
DFGout None 1 4ZLOA
None None 3 5KBQB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens PAK1_HUMAN AF-Q13153-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 262 - 529 None None 0
Homo sapiens PAK1_HUMAN 4ZLOB 2.5 None DFGin BLAminus out-none in-in No_ligand No_ligand 253 - 543 None X423 0
Homo sapiens PAK1_HUMAN 3Q52A 1.801 None DFGin BLAminus out-none in-in No_ligand No_ligand 250 - 542 K299R,L516I X423 0
Homo sapiens PAK1_HUMAN 1YHWA 1.8 None DFGin BLAminus out-none in-in No_ligand No_ligand 249 - 541 K299R None 0
Homo sapiens PAK1_HUMAN 8X5ZA 1.8 None DFGin BLAminus out-none in-in No_ligand No_ligand 249 - 543 K299R,E503D X423 0
Homo sapiens PAK1_HUMAN 1YHVA 1.8 None DFGin BLAminus out-none in-in No_ligand No_ligand 249 - 541 K299R,T423E None 0
Homo sapiens PAK1_HUMAN 4O0RB 2.4 None DFGin BLAminus out-out none-out No_ligand No_ligand 249 - 542 None None 8
Homo sapiens PAK1_HUMAN 3FXZA 1.64 None DFGin BLAminus out-none in-in FLL Type1 249 - 541 K299R X423 0
Homo sapiens PAK1_HUMAN 3FY0A 2.35 None DFGin BLAminus out-none in-in DW1 Type1 249 - 541 K299R X423 0
Homo sapiens PAK1_HUMAN 4DAWA 2.0 None DFGin BLAminus in-none in-in 0H2 Type1 249 - 542 K299R X423 0
Homo sapiens PAK1_HUMAN 3Q53A 2.09 None DFGin BLAminus out-none in-in ATP Type1 250 - 541 K299R,L516I X423 0
Homo sapiens PAK1_HUMAN 4ZY4A 2.6 Active DFGin BLAminus in-in in-in 4T3 Type1 249 - 541 D389N None 0
Homo sapiens PAK1_HUMAN 4ZY5A 2.35 Active DFGin BLAminus in-in in-in 4T5 Type1 251 - 542 None None 0
Homo sapiens PAK1_HUMAN 4ZY6A 2.15 Active DFGin BLAminus in-in in-in 4T6 Type1 251 - 542 D389N None 0
Homo sapiens PAK1_HUMAN 6B16A 2.285 Inactive DFGin BLAminus out-out in-in C7Y Type1 251 - 542 None None 0
Homo sapiens PAK1_HUMAN 7VTOA 2.59 Inactive DFGin BLAminus out-out in-in 107 Type1 257 - 542 None X423 0
Homo sapiens PAK1_HUMAN 2HY81 2.0 None DFGin BLAminus in-none in-in 1ST Type1 249 - 541 K299R,T423E None 0
Homo sapiens PAK1_HUMAN 5DEWA 1.9 Inactive DFGin BLAminus out-out in-in 59N Type1 250 - 544 D389N,T423E None 0
Homo sapiens PAK1_HUMAN 4O0RA 2.4 Inactive DFGin BLAminus out-out in-in 7KC Type1 249 - 541 None None 0
Homo sapiens PAK1_HUMAN 5KBQA 2.58 Inactive DFGin BLAminus out-out in-in IPV Type1 254 - 542 D389N,T423E,E503D None 0
Homo sapiens PAK1_HUMAN 5KBRA 2.36 Inactive DFGin BLAminus in-out in-in IPW Type1 255 - 542 D389N,T423E,E503D None 7
Homo sapiens PAK1_HUMAN 4P90A 2.49 Inactive DFGin BLAminus out-out in-in 2K0 Type1 250 - 542 D389N,T423E,E503D None 5
Homo sapiens PAK1_HUMAN 3Q4ZA 1.887 None DFGin BLAminus out-none in-in ANP Type1 251 - 545 S259I,K299R,D389N,L516I None 0
Homo sapiens PAK1_HUMAN 4EQCA 2.01 None DFGin BLAminus out-none in-in XR1 Type1.5_Back 249 - 541 K299R X423 0
Homo sapiens PAK1_HUMAN 5DEYA 2.1 Inactive DFGin BLAminus out-out in-in 59T Type1.5_Back 250 - 544 D389N,T423E None 0
Homo sapiens PAK1_HUMAN 4O0TA 2.6 Active DFGin BLAminus in-in in-in 2OL Type1.5_Back 251 - 542 None None 0
Homo sapiens PAK1_HUMAN 5IMEA 2.217 Inactive DFGin BLAminus out-out in-in 6BZ Type1.5_Back 251 - 545 None None 0
Homo sapiens PAK1_HUMAN 5DFPA 2.2 None DFGin BLAminus out-none in-in 59U Type1.5_Front 249 - 541 K299R X423 0
Homo sapiens PAK1_HUMAN 1F3MC 2.3 Inactive DFGin BLAplus out-none out-out No_ligand No_ligand 249 - 542 None None 7
Homo sapiens PAK1_HUMAN 1F3MD 2.3 Inactive DFGin BLAplus out-none out-out No_ligand No_ligand 249 - 542 None None 9
Homo sapiens PAK1_HUMAN 4ZY6B 2.15 Inactive DFGin BLAplus out-out none-out 4T6 Type1 255 - 542 D389N None 8
Homo sapiens PAK1_HUMAN 4ZY4B 2.6 Inactive DFGin BLBplus out-out out-out 4T3 Type1 249 - 541 D389N None 0
Homo sapiens PAK1_HUMAN 4ZY5B 2.35 Inactive DFGin BLBplus out-out out-out 4T5 Type1 255 - 542 None None 0
Homo sapiens PAK1_HUMAN 6B16B 2.285 Inactive DFGin BLBplus out-out none-out C7Y Type1 255 - 542 None None 7
Homo sapiens PAK1_HUMAN 5DEWB 1.9 Inactive DFGin BLBplus out-out none-out 59N Type1 255 - 542 D389N,T423E None 7
Homo sapiens PAK1_HUMAN 4O0TB 2.6 Inactive DFGin None out-out none-out No_ligand No_ligand 255 - 542 None None 8
Homo sapiens PAK1_HUMAN 3Q4ZB 1.887 Inactive DFGin None out-none none-out No_ligand No_ligand 250 - 541 S259I,K299R,D389N,L516I None 9
Homo sapiens PAK1_HUMAN 7VTOB 2.59 Inactive DFGin None out-out none-out 107 Type1 255 - 542 None X423 10
Homo sapiens PAK1_HUMAN 5DEYB 2.1 Inactive DFGin None out-out none-out 59T Type1 255 - 542 D389N,T423E None 7
Homo sapiens PAK1_HUMAN 5IMEB 2.217 Inactive DFGin None out-out none-out 6BZ Type1 250 - 541 None None 8
Homo sapiens PAK1_HUMAN 4ZJIA 1.99 Inactive DFGout BBAminus out-out out-in 4OQ Type3 254 - 542 None None 6
Homo sapiens PAK1_HUMAN 4ZJIB 1.99 Inactive DFGout BBAminus out-out out-in 4OQ Type3 254 - 540 None None 6
Homo sapiens PAK1_HUMAN 4ZJIC 1.99 Inactive DFGout BBAminus out-out out-out 4OQ Type3 250 - 541 None None 5
Homo sapiens PAK1_HUMAN 4ZJID 1.99 Inactive DFGout BBAminus out-out in-out 4OQ Type3 253 - 541 None None 4
Homo sapiens PAK1_HUMAN 4ZJJA 2.2 Inactive DFGout BBAminus out-out out-in 4OR Type3 249 - 539 None None 7
Homo sapiens PAK1_HUMAN 4ZJJB 2.2 Inactive DFGout BBAminus out-out out-in 4OR Type3 251 - 539 None None 7
Homo sapiens PAK1_HUMAN 4ZJJC 2.2 Inactive DFGout BBAminus out-none none-out 4OR Type3 251 - 542 None None 7
Homo sapiens PAK1_HUMAN 4ZJJD 2.2 Inactive DFGout BBAminus out-none none-out 4OR Type3 252 - 541 None None 4
Homo sapiens PAK1_HUMAN 4ZLOA 2.5 Inactive DFGout None out-out none-out 4PV Type3 250 - 543 None X423 9
Homo sapiens PAK1_HUMAN 5KBQB 2.58 Inactive None None out-out none-out No_ligand No_ligand 255 - 542 D389N,T423E,E503D None 11
Homo sapiens PAK1_HUMAN 5KBRB 2.36 Inactive None None out-out none-out IPW Type1 255 - 542 D389N,T423E,E503D None 11
Homo sapiens PAK1_HUMAN 4P90B 2.49 Inactive None None out-out none-out 2K0 Type1 257 - 542 D389N,T423E,E503D None 11

PAK1 (Serine/threonine-protein kinase PAK 1)

No non-human structures known.