MERTK (Tyrosine-protein kinase Mer)

Group: TYR
Uniprot: MERTK_HUMAN
Domain boundary: 587 - 856


Total number of chains: 57
Spatial Dihedral Chains Representative
DFGin BLAminus 2 AF-Q12866-K1A
DFGin BLAplus 1 7M5ZB
DFGin BLBminus 5 7AVYA
DFGin BLBplus 18 7AVXA
DFGin None 22 5U6CA
DFGout BBAminus 4 7AAYA
DFGout None 3 7AVXB
None None 2 7OAMA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q12866-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 579 - 864 None None 0
7AAZA 1.855 Inactive DFGin BLAminus out-out in-in R6K Type1.5_Front 574 - 863 None None 0
7M5ZB 3.06 Inactive DFGin BLAplus out-out none-none YR7 Type1 574 - 862 None None 19
7AVYA 2.31 Inactive DFGin BLBminus out-out none-none S4E Type1 576 - 863 None None 17
7AW2A 2.1 Inactive DFGin BLBminus out-out none-none S4W Type1.5_Front 571 - 862 K591R,K693R,K702R,K856R None 18
7OLSA 1.89 Inactive DFGin BLBminus out-out none-none VJZ Type1.5_Front 571 - 862 K591R,K693R,K702R,K856R None 19
7OLVA 2.13 Inactive DFGin BLBminus out-out none-none VK2 Type1.5_Front 571 - 862 K591R,K693R,K702R,K856R None 19
7OLXA 1.98 Inactive DFGin BLBminus out-out none-none VK5 Type1.5_Front 571 - 862 K591R,K693R,K702R,K856R None 19
7CQEA 2.69 Inactive DFGin BLBplus out-out none-none YDJ Type1 578 - 861 None None 19
7CQEC 2.69 Inactive DFGin BLBplus out-out none-none YDJ Type1 578 - 861 None None 19
7DXLA 3.146 Inactive DFGin BLBplus out-out none-out E56 Type1 575 - 863 I650M None 17
7DXLB 3.146 Inactive DFGin BLBplus out-out none-none E56 Type1 575 - 863 I650M None 19
2P0CA 2.4 Inactive DFGin BLBplus out-none none-none ANP Type1 575 - 861 None None 18
2P0CB 2.4 Inactive DFGin BLBplus out-none none-none ANP Type1 575 - 861 None None 18
3BPRA 2.8 Inactive DFGin BLBplus out-out none-none OLP Type1 575 - 863 None None 17
3BPRB 2.8 Inactive DFGin BLBplus out-out none-none OLP Type1 576 - 863 None None 17
3BPRC 2.8 Inactive DFGin BLBplus out-out none-none OLP Type1 575 - 863 None None 17
3BPRD 2.8 Inactive DFGin BLBplus out-out none-none OLP Type1 575 - 863 None None 17
3BRBA 1.9 Inactive DFGin BLBplus out-out none-out ADP Type1 575 - 861 None None 16
3BRBB 1.9 Inactive DFGin BLBplus out-out none-none ADP Type1 575 - 863 None None 18
4M3QB 2.718 Inactive DFGin BLBplus out-out none-none 24K Type1 577 - 861 None None 19
4MHAA 2.59 Inactive DFGin BLBplus out-out none-none 4MH Type1 580 - 863 None None 19
5K0KA 2.545 Inactive DFGin BLBplus out-out none-none 6Q1 Type1 577 - 863 None None 18
5K0XA 2.231 Inactive DFGin BLBplus out-out none-none K0X Type1 576 - 863 None None 19
6MEPA 2.893 Inactive DFGin BLBplus out-out none-none 9VS Type1.5_Back 576 - 863 None None 17
7AVXA 2.44 Inactive DFGin BLBplus out-out out-in S4K Type1.5_Front 577 - 862 None None 5
5TD2B 2.68 Inactive DFGin None out-out none-none No_ligand No_ligand 577 - 861 None None 20
4MH7B 2.51 Inactive DFGin None out-out none-none No_ligand No_ligand 577 - 862 None None 20
5TC0B 2.24 Inactive DFGin None out-out none-none No_ligand No_ligand 578 - 861 None None 20
7AB0A 1.74 Inactive DFGin None out-out none-none No_ligand No_ligand 571 - 862 K591R,K693R,K702R,K856R None 20
5TD2A 2.68 Inactive DFGin None none-none none-none 7AE Type1 577 - 861 None None 20
7OAMB 2.65 Inactive DFGin None none-none none-out V6H Type1 576 - 862 None None 19
3TCPA 2.69 Inactive DFGin None out-out none-none CKJ Type1 577 - 863 None None 20
3TCPB 2.69 Inactive DFGin None out-none none-out CKJ Type1 576 - 861 None None 19
4M3QA 2.718 Inactive DFGin None none-none none-none 24K Type1 578 - 861 None None 20
4MH7A 2.51 Inactive DFGin None none-none none-none MH7 Type1 577 - 861 None None 20
4MHAB 2.59 Inactive DFGin None none-none none-none 4MH Type1 577 - 862 None None 20
5K0KB 2.545 Inactive DFGin None out-out none-none 6Q1 Type1 577 - 862 None None 20
5TC0A 2.24 Inactive DFGin None none-none none-in 79Y Type1 578 - 861 None None 19
5U6CA 2.1 Inactive DFGin None out-out none-none 7YS Type1 572 - 864 None None 17
5U6CB 2.1 Inactive DFGin None out-out none-out 7YS Type1 575 - 862 None None 19
7AB1A 1.93 Inactive DFGin None out-out none-none C6F Type1 571 - 862 K591R,K693R,K702R,K856R None 20
7AB2A 1.78 Inactive DFGin None out-out none-none R6N Type1 571 - 862 K591R,K693R,K702R,K856R None 20
7AVZA 2.04 Inactive DFGin None out-out none-none S4N Type1 571 - 862 K591R,K693R,K702R,K856R None 20
7AW0A 1.893 Inactive DFGin None out-out none-none S4Q Type1 571 - 862 K591R,K693R,K702R,K856R None 20
7AW3A 1.99 Inactive DFGin None out-out none-none S4Z Type1 571 - 862 K591R,K693R,K702R,K856R None 20
7M5ZA 3.06 Inactive DFGin None in-out none-none YR7 Type1 577 - 862 None None 20
6MEPB 2.893 Inactive DFGin None out-out none-none 9VS Type1.5_Back 578 - 862 None None 20
7XHYA 2.16 Inactive DFGout BBAminus out-out none-none E0X Type1 571 - 862 K591R,K693R,K702R,K856R None 18
7AAYA 1.87 Inactive DFGout BBAminus in-in none-out L1X Type2 571 - 862 None None 18
7AW4A 1.98 Inactive DFGout BBAminus out-out none-none S5E Type3 576 - 862 None None 17
7AW4B 1.98 Inactive DFGout BBAminus out-out none-none S5E Type3 574 - 862 None None 18
7AVXB 2.44 Inactive DFGout None out-out none-none S4K Type1 577 - 862 None None 20
7AAXA 1.762 Inactive DFGout None out-out none-none R6H Type2 571 - 862 K591R,K693R,K702R,K856R None 20
7AW1A 1.98 Inactive DFGout None out-out none-none S4T Type2 571 - 862 K591R,K693R,K702R,K856R None 20
7OAMA 2.65 Inactive None None out-none none-out No_ligand No_ligand 575 - 863 None None 19
5K0XB 2.231 Inactive None None out-out none-none K0X Type1 575 - 863 None None 21

MERTK (Tyrosine-protein kinase Mer)

Group: TYR
Total number of chains: 57
Spatial Dihedral Chains Representative
DFGin BLAminus 2 AF-Q12866-K1A
DFGin BLAplus 1 7M5ZB
DFGin BLBminus 5 7AVYA
DFGin BLBplus 18 7AVXA
DFGin None 22 5U6CA
DFGout BBAminus 4 7AAYA
DFGout None 3 7AVXB
None None 2 7OAMA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens MERTK_HUMAN AF-Q12866-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 579 - 864 None None 0
Homo sapiens MERTK_HUMAN 7AAZA 1.855 Inactive DFGin BLAminus out-out in-in R6K Type1.5_Front 574 - 863 None None 0
Homo sapiens MERTK_HUMAN 7M5ZB 3.06 Inactive DFGin BLAplus out-out none-none YR7 Type1 574 - 862 None None 19
Homo sapiens MERTK_HUMAN 7AVYA 2.31 Inactive DFGin BLBminus out-out none-none S4E Type1 576 - 863 None None 17
Homo sapiens MERTK_HUMAN 7AW2A 2.1 Inactive DFGin BLBminus out-out none-none S4W Type1.5_Front 571 - 862 K591R,K693R,K702R,K856R None 18
Homo sapiens MERTK_HUMAN 7OLSA 1.89 Inactive DFGin BLBminus out-out none-none VJZ Type1.5_Front 571 - 862 K591R,K693R,K702R,K856R None 19
Homo sapiens MERTK_HUMAN 7OLVA 2.13 Inactive DFGin BLBminus out-out none-none VK2 Type1.5_Front 571 - 862 K591R,K693R,K702R,K856R None 19
Homo sapiens MERTK_HUMAN 7OLXA 1.98 Inactive DFGin BLBminus out-out none-none VK5 Type1.5_Front 571 - 862 K591R,K693R,K702R,K856R None 19
Homo sapiens MERTK_HUMAN 7CQEA 2.69 Inactive DFGin BLBplus out-out none-none YDJ Type1 578 - 861 None None 19
Homo sapiens MERTK_HUMAN 7CQEC 2.69 Inactive DFGin BLBplus out-out none-none YDJ Type1 578 - 861 None None 19
Homo sapiens MERTK_HUMAN 7DXLA 3.146 Inactive DFGin BLBplus out-out none-out E56 Type1 575 - 863 I650M None 17
Homo sapiens MERTK_HUMAN 7DXLB 3.146 Inactive DFGin BLBplus out-out none-none E56 Type1 575 - 863 I650M None 19
Homo sapiens MERTK_HUMAN 2P0CA 2.4 Inactive DFGin BLBplus out-none none-none ANP Type1 575 - 861 None None 18
Homo sapiens MERTK_HUMAN 2P0CB 2.4 Inactive DFGin BLBplus out-none none-none ANP Type1 575 - 861 None None 18
Homo sapiens MERTK_HUMAN 3BPRA 2.8 Inactive DFGin BLBplus out-out none-none OLP Type1 575 - 863 None None 17
Homo sapiens MERTK_HUMAN 3BPRB 2.8 Inactive DFGin BLBplus out-out none-none OLP Type1 576 - 863 None None 17
Homo sapiens MERTK_HUMAN 3BPRC 2.8 Inactive DFGin BLBplus out-out none-none OLP Type1 575 - 863 None None 17
Homo sapiens MERTK_HUMAN 3BPRD 2.8 Inactive DFGin BLBplus out-out none-none OLP Type1 575 - 863 None None 17
Homo sapiens MERTK_HUMAN 3BRBA 1.9 Inactive DFGin BLBplus out-out none-out ADP Type1 575 - 861 None None 16
Homo sapiens MERTK_HUMAN 3BRBB 1.9 Inactive DFGin BLBplus out-out none-none ADP Type1 575 - 863 None None 18
Homo sapiens MERTK_HUMAN 4M3QB 2.718 Inactive DFGin BLBplus out-out none-none 24K Type1 577 - 861 None None 19
Homo sapiens MERTK_HUMAN 4MHAA 2.59 Inactive DFGin BLBplus out-out none-none 4MH Type1 580 - 863 None None 19
Homo sapiens MERTK_HUMAN 5K0KA 2.545 Inactive DFGin BLBplus out-out none-none 6Q1 Type1 577 - 863 None None 18
Homo sapiens MERTK_HUMAN 5K0XA 2.231 Inactive DFGin BLBplus out-out none-none K0X Type1 576 - 863 None None 19
Homo sapiens MERTK_HUMAN 6MEPA 2.893 Inactive DFGin BLBplus out-out none-none 9VS Type1.5_Back 576 - 863 None None 17
Homo sapiens MERTK_HUMAN 7AVXA 2.44 Inactive DFGin BLBplus out-out out-in S4K Type1.5_Front 577 - 862 None None 5
Homo sapiens MERTK_HUMAN 5TD2B 2.68 Inactive DFGin None out-out none-none No_ligand No_ligand 577 - 861 None None 20
Homo sapiens MERTK_HUMAN 4MH7B 2.51 Inactive DFGin None out-out none-none No_ligand No_ligand 577 - 862 None None 20
Homo sapiens MERTK_HUMAN 5TC0B 2.24 Inactive DFGin None out-out none-none No_ligand No_ligand 578 - 861 None None 20
Homo sapiens MERTK_HUMAN 7AB0A 1.74 Inactive DFGin None out-out none-none No_ligand No_ligand 571 - 862 K591R,K693R,K702R,K856R None 20
Homo sapiens MERTK_HUMAN 5TD2A 2.68 Inactive DFGin None none-none none-none 7AE Type1 577 - 861 None None 20
Homo sapiens MERTK_HUMAN 7OAMB 2.65 Inactive DFGin None none-none none-out V6H Type1 576 - 862 None None 19
Homo sapiens MERTK_HUMAN 3TCPA 2.69 Inactive DFGin None out-out none-none CKJ Type1 577 - 863 None None 20
Homo sapiens MERTK_HUMAN 3TCPB 2.69 Inactive DFGin None out-none none-out CKJ Type1 576 - 861 None None 19
Homo sapiens MERTK_HUMAN 4M3QA 2.718 Inactive DFGin None none-none none-none 24K Type1 578 - 861 None None 20
Homo sapiens MERTK_HUMAN 4MH7A 2.51 Inactive DFGin None none-none none-none MH7 Type1 577 - 861 None None 20
Homo sapiens MERTK_HUMAN 4MHAB 2.59 Inactive DFGin None none-none none-none 4MH Type1 577 - 862 None None 20
Homo sapiens MERTK_HUMAN 5K0KB 2.545 Inactive DFGin None out-out none-none 6Q1 Type1 577 - 862 None None 20
Homo sapiens MERTK_HUMAN 5TC0A 2.24 Inactive DFGin None none-none none-in 79Y Type1 578 - 861 None None 19
Homo sapiens MERTK_HUMAN 5U6CA 2.1 Inactive DFGin None out-out none-none 7YS Type1 572 - 864 None None 17
Homo sapiens MERTK_HUMAN 5U6CB 2.1 Inactive DFGin None out-out none-out 7YS Type1 575 - 862 None None 19
Homo sapiens MERTK_HUMAN 7AB1A 1.93 Inactive DFGin None out-out none-none C6F Type1 571 - 862 K591R,K693R,K702R,K856R None 20
Homo sapiens MERTK_HUMAN 7AB2A 1.78 Inactive DFGin None out-out none-none R6N Type1 571 - 862 K591R,K693R,K702R,K856R None 20
Homo sapiens MERTK_HUMAN 7AVZA 2.04 Inactive DFGin None out-out none-none S4N Type1 571 - 862 K591R,K693R,K702R,K856R None 20
Homo sapiens MERTK_HUMAN 7AW0A 1.893 Inactive DFGin None out-out none-none S4Q Type1 571 - 862 K591R,K693R,K702R,K856R None 20
Homo sapiens MERTK_HUMAN 7AW3A 1.99 Inactive DFGin None out-out none-none S4Z Type1 571 - 862 K591R,K693R,K702R,K856R None 20
Homo sapiens MERTK_HUMAN 7M5ZA 3.06 Inactive DFGin None in-out none-none YR7 Type1 577 - 862 None None 20
Homo sapiens MERTK_HUMAN 6MEPB 2.893 Inactive DFGin None out-out none-none 9VS Type1.5_Back 578 - 862 None None 20
Homo sapiens MERTK_HUMAN 7XHYA 2.16 Inactive DFGout BBAminus out-out none-none E0X Type1 571 - 862 K591R,K693R,K702R,K856R None 18
Homo sapiens MERTK_HUMAN 7AAYA 1.87 Inactive DFGout BBAminus in-in none-out L1X Type2 571 - 862 None None 18
Homo sapiens MERTK_HUMAN 7AW4A 1.98 Inactive DFGout BBAminus out-out none-none S5E Type3 576 - 862 None None 17
Homo sapiens MERTK_HUMAN 7AW4B 1.98 Inactive DFGout BBAminus out-out none-none S5E Type3 574 - 862 None None 18
Homo sapiens MERTK_HUMAN 7AVXB 2.44 Inactive DFGout None out-out none-none S4K Type1 577 - 862 None None 20
Homo sapiens MERTK_HUMAN 7AAXA 1.762 Inactive DFGout None out-out none-none R6H Type2 571 - 862 K591R,K693R,K702R,K856R None 20
Homo sapiens MERTK_HUMAN 7AW1A 1.98 Inactive DFGout None out-out none-none S4T Type2 571 - 862 K591R,K693R,K702R,K856R None 20
Homo sapiens MERTK_HUMAN 7OAMA 2.65 Inactive None None out-none none-out No_ligand No_ligand 575 - 863 None None 19
Homo sapiens MERTK_HUMAN 5K0XB 2.231 Inactive None None out-out none-none K0X Type1 575 - 863 None None 21

MERTK (Tyrosine-protein kinase Mer)

No non-human structures known.