LIMK2 (LIM domain kinase 2)

Group: TKL
Uniprot: LIMK2_HUMAN
Domain boundary: 331 - 603


Total number of chains: 15
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-P53671-K1A
DFGin BLBplus 8 8WSWA
DFGout BBAminus 5 7QHGA
DFGout None 1 5NXDA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P53671-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 323 - 611 None None 0
8WSWA 2.5 Inactive DFGin BLBplus out-out out-out LH0 Type1 330 - 632 None None 22
8WSWB 2.5 Inactive DFGin BLBplus out-out out-out LH0 Type1 330 - 632 None None 22
8WSWC 2.5 Inactive DFGin BLBplus out-out out-out LH0 Type1 330 - 632 None None 22
8WSWD 2.5 Inactive DFGin BLBplus out-out out-out LH0 Type1 330 - 632 None None 22
8S3XA 2.59 Inactive DFGin BLBplus out-none out-out A1H41 Type1 334 - 631 None None 21
8S3XB 2.59 Inactive DFGin BLBplus out-none out-out A1H41 Type1 330 - 631 None None 24
8S3XC 2.59 Inactive DFGin BLBplus out-out out-out A1H41 Type1 330 - 631 None None 25
8S3XD 2.59 Inactive DFGin BLBplus out-none out-out A1H41 Type1 331 - 631 None None 26
7QHGA 1.45 Inactive DFGout BBAminus out-out out-out T3B Type2 330 - 632 None None 21
7QHGB 1.45 Inactive DFGout BBAminus out-out out-out T3B Type2 330 - 632 None None 22
4TPTA 2.6 Inactive DFGout BBAminus out-out out-in 35H Type3 330 - 631 None None 23
4TPTB 2.6 Inactive DFGout BBAminus out-out out-in 35H Type3 330 - 632 None None 26
5NXDB 1.9 Inactive DFGout BBAminus out-out out-none 9D8 Type3 330 - 632 None None 32
5NXDA 1.9 Inactive DFGout None out-out out-none 9D8 Type3 330 - 632 None None 32

LIMK2 (LIM domain kinase 2)

Group: TKL
Total number of chains: 15
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-P53671-K1A
DFGin BLBplus 8 8WSWA
DFGout BBAminus 5 7QHGA
DFGout None 1 5NXDA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens LIMK2_HUMAN AF-P53671-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 323 - 611 None None 0
Homo sapiens LIMK2_HUMAN 8WSWA 2.5 Inactive DFGin BLBplus out-out out-out LH0 Type1 330 - 632 None None 22
Homo sapiens LIMK2_HUMAN 8WSWB 2.5 Inactive DFGin BLBplus out-out out-out LH0 Type1 330 - 632 None None 22
Homo sapiens LIMK2_HUMAN 8WSWC 2.5 Inactive DFGin BLBplus out-out out-out LH0 Type1 330 - 632 None None 22
Homo sapiens LIMK2_HUMAN 8WSWD 2.5 Inactive DFGin BLBplus out-out out-out LH0 Type1 330 - 632 None None 22
Homo sapiens LIMK2_HUMAN 8S3XA 2.59 Inactive DFGin BLBplus out-none out-out A1H41 Type1 334 - 631 None None 21
Homo sapiens LIMK2_HUMAN 8S3XB 2.59 Inactive DFGin BLBplus out-none out-out A1H41 Type1 330 - 631 None None 24
Homo sapiens LIMK2_HUMAN 8S3XC 2.59 Inactive DFGin BLBplus out-out out-out A1H41 Type1 330 - 631 None None 25
Homo sapiens LIMK2_HUMAN 8S3XD 2.59 Inactive DFGin BLBplus out-none out-out A1H41 Type1 331 - 631 None None 26
Homo sapiens LIMK2_HUMAN 7QHGA 1.45 Inactive DFGout BBAminus out-out out-out T3B Type2 330 - 632 None None 21
Homo sapiens LIMK2_HUMAN 7QHGB 1.45 Inactive DFGout BBAminus out-out out-out T3B Type2 330 - 632 None None 22
Homo sapiens LIMK2_HUMAN 4TPTA 2.6 Inactive DFGout BBAminus out-out out-in 35H Type3 330 - 631 None None 23
Homo sapiens LIMK2_HUMAN 4TPTB 2.6 Inactive DFGout BBAminus out-out out-in 35H Type3 330 - 632 None None 26
Homo sapiens LIMK2_HUMAN 5NXDB 1.9 Inactive DFGout BBAminus out-out out-none 9D8 Type3 330 - 632 None None 32
Homo sapiens LIMK2_HUMAN 5NXDA 1.9 Inactive DFGout None out-out out-none 9D8 Type3 330 - 632 None None 32

LIMK2 (LIM domain kinase 2)

No non-human structures known.