LIMK1 (LIM domain kinase 1)

Group: TKL
Uniprot: LIMK1_HUMAN
Domain boundary: 339 - 606


Total number of chains: 19
Spatial Dihedral Chains Representative
DFGin BLAminus 8 AF-P53667-K1A
DFGin BLBplus 1 7ATSA
DFGin None 2 5HVKC
DFGout BBAminus 8 7ATUB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P53667-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 331 - 614 None None 0
5HVJB 2.2 Active DFGin BLAminus in-in in-in No_ligand No_ligand 330 - 637 D460N None 24
3S95A 1.65 Active DFGin BLAminus in-in in-in STU Type1 330 - 637 None None 20
3S95B 1.65 Active DFGin BLAminus in-in in-in STU Type1 330 - 637 None None 20
5L6WL 2.53 Active DFGin BLAminus in-in in-in AGS Type1 330 - 633 None None 16
8AAUL 1.74 Active DFGin BLAminus in-in in-in LH0 Type1 330 - 634 None None 16
5HVJA 2.2 Inactive DFGin BLAminus in-in in-out ANP Type1 329 - 633 D460N None 22
5HVKA 3.5 Active DFGin BLAminus in-in in-in ANP Type1 329 - 634 D460N X508 13
7ATSA 2.8 Inactive DFGin BLBplus out-none none-none RXQ Type1.5_Back 330 - 634 None None 32
5NXCL 2.25 Inactive DFGin None out-out none-out 9DB Type1 330 - 632 None None 31
5HVKC 3.5 Inactive DFGin None in-out in-in ANP Type1 329 - 633 D460N X508 14
7B8WA 2.8 Inactive DFGout BBAminus out-out out-none T3B Type2 330 - 633 None None 25
7B8WB 2.8 Inactive DFGout BBAminus out-out out-none T3B Type2 330 - 632 None None 25
7B8WC 2.8 Inactive DFGout BBAminus out-out out-none T3B Type2 330 - 632 None None 26
7B8WD 2.8 Inactive DFGout BBAminus out-out out-none T3B Type2 331 - 632 None None 25
7ATUA 2.8 Inactive DFGout BBAminus out-out out-out RXN Type3 330 - 634 None None 21
7ATUB 2.8 Inactive DFGout BBAminus out-out out-out RXN Type3 330 - 636 None None 20
7ATUC 2.8 Inactive DFGout BBAminus out-none out-none RXN Type3 350 - 632 None None 26
7ATUD 2.8 Inactive DFGout BBAminus out-none out-out RXN Type3 354 - 632 None None 25

LIMK1 (LIM domain kinase 1)

Group: TKL
Total number of chains: 19
Spatial Dihedral Chains Representative
DFGin BLAminus 8 AF-P53667-K1A
DFGin BLBplus 1 7ATSA
DFGin None 2 5HVKC
DFGout BBAminus 8 7ATUB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens LIMK1_HUMAN AF-P53667-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 331 - 614 None None 0
Homo sapiens LIMK1_HUMAN 5HVJB 2.2 Active DFGin BLAminus in-in in-in No_ligand No_ligand 330 - 637 D460N None 24
Homo sapiens LIMK1_HUMAN 3S95A 1.65 Active DFGin BLAminus in-in in-in STU Type1 330 - 637 None None 20
Homo sapiens LIMK1_HUMAN 3S95B 1.65 Active DFGin BLAminus in-in in-in STU Type1 330 - 637 None None 20
Homo sapiens LIMK1_HUMAN 5L6WL 2.53 Active DFGin BLAminus in-in in-in AGS Type1 330 - 633 None None 16
Homo sapiens LIMK1_HUMAN 8AAUL 1.74 Active DFGin BLAminus in-in in-in LH0 Type1 330 - 634 None None 16
Homo sapiens LIMK1_HUMAN 5HVJA 2.2 Inactive DFGin BLAminus in-in in-out ANP Type1 329 - 633 D460N None 22
Homo sapiens LIMK1_HUMAN 5HVKA 3.5 Active DFGin BLAminus in-in in-in ANP Type1 329 - 634 D460N X508 13
Homo sapiens LIMK1_HUMAN 7ATSA 2.8 Inactive DFGin BLBplus out-none none-none RXQ Type1.5_Back 330 - 634 None None 32
Homo sapiens LIMK1_HUMAN 5NXCL 2.25 Inactive DFGin None out-out none-out 9DB Type1 330 - 632 None None 31
Homo sapiens LIMK1_HUMAN 5HVKC 3.5 Inactive DFGin None in-out in-in ANP Type1 329 - 633 D460N X508 14
Homo sapiens LIMK1_HUMAN 7B8WA 2.8 Inactive DFGout BBAminus out-out out-none T3B Type2 330 - 633 None None 25
Homo sapiens LIMK1_HUMAN 7B8WB 2.8 Inactive DFGout BBAminus out-out out-none T3B Type2 330 - 632 None None 25
Homo sapiens LIMK1_HUMAN 7B8WC 2.8 Inactive DFGout BBAminus out-out out-none T3B Type2 330 - 632 None None 26
Homo sapiens LIMK1_HUMAN 7B8WD 2.8 Inactive DFGout BBAminus out-out out-none T3B Type2 331 - 632 None None 25
Homo sapiens LIMK1_HUMAN 7ATUA 2.8 Inactive DFGout BBAminus out-out out-out RXN Type3 330 - 634 None None 21
Homo sapiens LIMK1_HUMAN 7ATUB 2.8 Inactive DFGout BBAminus out-out out-out RXN Type3 330 - 636 None None 20
Homo sapiens LIMK1_HUMAN 7ATUC 2.8 Inactive DFGout BBAminus out-none out-none RXN Type3 350 - 632 None None 26
Homo sapiens LIMK1_HUMAN 7ATUD 2.8 Inactive DFGout BBAminus out-none out-out RXN Type3 354 - 632 None None 25

LIMK1 (LIM domain kinase 1)

No non-human structures known.