CLK1 (Dual specificity protein kinase CLK1)

Group: CMGC
Uniprot: CLK1_HUMAN
Domain boundary: 161 - 477


Total number of chains: 59
Spatial Dihedral Chains Representative
DFGin BLAminus 57 AF-P49759-K1A
DFGin ABAminus 1 6KHDC
DFGin None 1 6KHDA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
6KHDC 2.7 Inactive DFGin ABAminus in-in in-out 3NG Type1 150 - 479 None None 0
AF-P49759-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 153 - 484 None None 0
6YTDA 2.0 Active DFGin BLAminus in-in in-in EAE Type1 148 - 484 V324A None 0
6QTYA 1.65 Active DFGin BLAminus in-in in-in V25 Type1 149 - 481 None None 0
6R3DA 1.85 Active DFGin BLAminus in-in in-in JQW Type1 152 - 481 None None 0
6R6EA 2.25 Active DFGin BLAminus in-in in-in JTQ Type1 153 - 481 None None 0
6R6XA 2.05 Active DFGin BLAminus in-in in-in JU8 Type1 152 - 481 None None 0
7O9YA 1.66 Active DFGin BLAminus in-in in-in V5T Type1 152 - 481 None None 0
7OA0AAA 1.81 Active DFGin BLAminus in-in in-in JTQ Type1 152 - 481 None None 0
1Z57A 1.7 Active DFGin BLAminus in-in in-in DBQ Type1 148 - 482 None None 0
2VAGA 1.8 None DFGin BLAminus in-in in-none V25 Type1 148 - 481 None X341,X342 0
5J1VA 2.52 Active DFGin BLAminus in-in in-in 6FD Type1 148 - 483 None None 0
5J1VB 2.52 Active DFGin BLAminus in-in in-in 6FD Type1 148 - 482 None None 0
5J1VC 2.52 None DFGin BLAminus in-in in-none 6FD Type1 148 - 483 None None 3
5J1WA 2.42 Active DFGin BLAminus in-in in-in 6FB Type1 148 - 483 None None 0
5J1WB 2.42 Active DFGin BLAminus in-in in-in 6FB Type1 148 - 482 None None 0
6FT8A 1.45 Active DFGin BLAminus in-in in-in E6T Type1 148 - 483 None None 0
6FT9A 1.87 Active DFGin BLAminus in-in in-in E6W Type1 148 - 482 None None 0
6FT9B 1.87 Active DFGin BLAminus in-in in-in E6W Type1 148 - 482 None None 0
6FT9C 1.87 Inactive DFGin BLAminus in-in in-out E6W Type1 148 - 482 None None 0
6G33A 2.05 None DFGin BLAminus in-in in-none 5ID Type1 148 - 482 None X341,X342 0
6G33B 2.05 Inactive DFGin BLAminus in-in in-out 5ID Type1 148 - 482 None None 0
6G33C 2.05 Active DFGin BLAminus in-in in-in 5ID Type1 148 - 482 None None 0
6I5HA 1.49 Active DFGin BLAminus in-in in-in H3N Type1 148 - 481 None None 0
6I5IA 1.6 Active DFGin BLAminus in-in in-in H3E Type1 148 - 483 None None 0
6I5KA 2.3 Inactive DFGin BLAminus in-in in-out H3H Type1 148 - 482 None None 0
6I5KB 2.3 Active DFGin BLAminus in-in in-in H3H Type1 148 - 481 None None 0
6I5KC 2.3 Active DFGin BLAminus in-in in-in H3H Type1 148 - 483 None None 0
6I5LA 2.55 Inactive DFGin BLAminus in-in in-out H3Q Type1 148 - 483 None None 0
6I5LB 2.55 Active DFGin BLAminus in-in in-in H3Q Type1 148 - 481 None None 0
6I5LC 2.55 Active DFGin BLAminus in-in in-in H3Q Type1 148 - 483 None None 0
6Q8KA 2.29 Active DFGin BLAminus in-in in-in FG9 Type1 148 - 484 None None 0
6Q8PA 3.0 None DFGin BLAminus in-in in-none HQB Type1 148 - 482 None None 1
6Q8PB 3.0 None DFGin BLAminus in-in in-none HQB Type1 148 - 483 None None 2
6Q8PC 3.0 None DFGin BLAminus in-in in-none HQB Type1 148 - 483 None None 1
6RAAA 2.1 Active DFGin BLAminus in-in in-in JWN Type1 148 - 481 None None 0
6TW2E 1.8 Active DFGin BLAminus in-in in-in V25 Type1 148 - 484 None X341,X342 0
6YTAA 2.3 Active DFGin BLAminus in-in in-in IYZ Type1 148 - 483 None None 0
6YTEC 2.3 Active DFGin BLAminus in-in in-in EAE Type1 148 - 484 None None 0
6YTIA 2.4 Active DFGin BLAminus in-in in-in 7A7 Type1 150 - 482 None None 0
6Z4ZA 2.07 Active DFGin BLAminus in-in in-in PQ5 Type1 148 - 482 None None 0
6Z4ZB 2.07 Active DFGin BLAminus in-in in-in PQ5 Type1 148 - 484 None None 0
6Z4ZC 2.07 Active DFGin BLAminus in-in in-in PQ5 Type1 148 - 482 None None 0
6Z50A 1.6 Inactive DFGin BLAminus in-out in-in Q7K Type1 149 - 481 None None 0
6ZLNA 1.7 Active DFGin BLAminus in-in in-in PKB Type1 148 - 484 None None 0
7AK3A 2.5 Active DFGin BLAminus in-in in-in RH8 Type1 148 - 483 None None 0
7OPGA 1.93 Active DFGin BLAminus in-in in-in 06N Type1 148 - 482 None None 0
7OPGB 1.93 Active DFGin BLAminus in-in in-in 06N Type1 148 - 483 None None 0
7OPGC 1.93 Active DFGin BLAminus in-in in-in 06N Type1 148 - 482 None None 0
8P04A 2.6 Active DFGin BLAminus in-in in-in WAK Type1 148 - 481 None None 6
8P08A 2.4 Inactive DFGin BLAminus in-in in-out WAZ Type1 148 - 481 None None 0
6FYOA 2.32 Active DFGin BLAminus in-in in-in EAQ Type1 148 - 481 None None 0
5X8IA 1.902 Active DFGin BLAminus in-in in-in SQZ Type1 154 - 481 R432A None 0
5X8IB 1.902 Active DFGin BLAminus in-in in-in SQZ Type1 155 - 481 R432A None 0
6KHDB 2.7 Active DFGin BLAminus in-in in-in 3NG Type1 149 - 482 None None 0
5J1WC 2.42 Inactive DFGin BLAminus in-in in-out 6FB 6FB Type1 Allosteric 148 - 483 None None 0
6YTGA 1.95 Active DFGin BLAminus in-in in-in KHC KHC Type1 Allosteric 148 - 483 None None 0
6R8JA 1.75 Active DFGin BLAminus in-in in-in JUW JUW Type1 Type1 152 - 481 None None 0
6KHDA 2.7 Inactive DFGin None in-in in-none 3NG Type1 149 - 481 None None 2

CLK1 (Dual specificity protein kinase CLK1)

Group: CMGC
Total number of chains: 75
Spatial Dihedral Chains Representative
DFGin BLAminus 73 AF-P49759-K1A
DFGin ABAminus 1 6KHDC
DFGin None 1 6KHDA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens CLK1_HUMAN 6KHDC 2.7 Inactive DFGin ABAminus in-in in-out 3NG Type1 150 - 479 None None 0
Homo sapiens CLK1_HUMAN AF-P49759-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 153 - 484 None None 0
Homo sapiens CLK1_HUMAN 6YTDA 2.0 Active DFGin BLAminus in-in in-in EAE Type1 148 - 484 V324A None 0
Homo sapiens CLK1_HUMAN 6QTYA 1.65 Active DFGin BLAminus in-in in-in V25 Type1 149 - 481 None None 0
Homo sapiens CLK1_HUMAN 6R3DA 1.85 Active DFGin BLAminus in-in in-in JQW Type1 152 - 481 None None 0
Homo sapiens CLK1_HUMAN 6R6EA 2.25 Active DFGin BLAminus in-in in-in JTQ Type1 153 - 481 None None 0
Homo sapiens CLK1_HUMAN 6R6XA 2.05 Active DFGin BLAminus in-in in-in JU8 Type1 152 - 481 None None 0
Homo sapiens CLK1_HUMAN 7O9YA 1.66 Active DFGin BLAminus in-in in-in V5T Type1 152 - 481 None None 0
Homo sapiens CLK1_HUMAN 7OA0AAA 1.81 Active DFGin BLAminus in-in in-in JTQ Type1 152 - 481 None None 0
Homo sapiens CLK1_HUMAN 1Z57A 1.7 Active DFGin BLAminus in-in in-in DBQ Type1 148 - 482 None None 0
Homo sapiens CLK1_HUMAN 2VAGA 1.8 None DFGin BLAminus in-in in-none V25 Type1 148 - 481 None X341,X342 0
Homo sapiens CLK1_HUMAN 5J1VA 2.52 Active DFGin BLAminus in-in in-in 6FD Type1 148 - 483 None None 0
Homo sapiens CLK1_HUMAN 5J1VB 2.52 Active DFGin BLAminus in-in in-in 6FD Type1 148 - 482 None None 0
Homo sapiens CLK1_HUMAN 5J1VC 2.52 None DFGin BLAminus in-in in-none 6FD Type1 148 - 483 None None 3
Homo sapiens CLK1_HUMAN 5J1WA 2.42 Active DFGin BLAminus in-in in-in 6FB Type1 148 - 483 None None 0
Homo sapiens CLK1_HUMAN 5J1WB 2.42 Active DFGin BLAminus in-in in-in 6FB Type1 148 - 482 None None 0
Homo sapiens CLK1_HUMAN 6FT8A 1.45 Active DFGin BLAminus in-in in-in E6T Type1 148 - 483 None None 0
Homo sapiens CLK1_HUMAN 6FT9A 1.87 Active DFGin BLAminus in-in in-in E6W Type1 148 - 482 None None 0
Homo sapiens CLK1_HUMAN 6FT9B 1.87 Active DFGin BLAminus in-in in-in E6W Type1 148 - 482 None None 0
Homo sapiens CLK1_HUMAN 6FT9C 1.87 Inactive DFGin BLAminus in-in in-out E6W Type1 148 - 482 None None 0
Homo sapiens CLK1_HUMAN 6G33A 2.05 None DFGin BLAminus in-in in-none 5ID Type1 148 - 482 None X341,X342 0
Homo sapiens CLK1_HUMAN 6G33B 2.05 Inactive DFGin BLAminus in-in in-out 5ID Type1 148 - 482 None None 0
Homo sapiens CLK1_HUMAN 6G33C 2.05 Active DFGin BLAminus in-in in-in 5ID Type1 148 - 482 None None 0
Homo sapiens CLK1_HUMAN 6I5HA 1.49 Active DFGin BLAminus in-in in-in H3N Type1 148 - 481 None None 0
Homo sapiens CLK1_HUMAN 6I5IA 1.6 Active DFGin BLAminus in-in in-in H3E Type1 148 - 483 None None 0
Homo sapiens CLK1_HUMAN 6I5KA 2.3 Inactive DFGin BLAminus in-in in-out H3H Type1 148 - 482 None None 0
Homo sapiens CLK1_HUMAN 6I5KB 2.3 Active DFGin BLAminus in-in in-in H3H Type1 148 - 481 None None 0
Homo sapiens CLK1_HUMAN 6I5KC 2.3 Active DFGin BLAminus in-in in-in H3H Type1 148 - 483 None None 0
Homo sapiens CLK1_HUMAN 6I5LA 2.55 Inactive DFGin BLAminus in-in in-out H3Q Type1 148 - 483 None None 0
Homo sapiens CLK1_HUMAN 6I5LB 2.55 Active DFGin BLAminus in-in in-in H3Q Type1 148 - 481 None None 0
Homo sapiens CLK1_HUMAN 6I5LC 2.55 Active DFGin BLAminus in-in in-in H3Q Type1 148 - 483 None None 0
Homo sapiens CLK1_HUMAN 6Q8KA 2.29 Active DFGin BLAminus in-in in-in FG9 Type1 148 - 484 None None 0
Homo sapiens CLK1_HUMAN 6Q8PA 3.0 None DFGin BLAminus in-in in-none HQB Type1 148 - 482 None None 1
Homo sapiens CLK1_HUMAN 6Q8PB 3.0 None DFGin BLAminus in-in in-none HQB Type1 148 - 483 None None 2
Homo sapiens CLK1_HUMAN 6Q8PC 3.0 None DFGin BLAminus in-in in-none HQB Type1 148 - 483 None None 1
Homo sapiens CLK1_HUMAN 6RAAA 2.1 Active DFGin BLAminus in-in in-in JWN Type1 148 - 481 None None 0
Homo sapiens CLK1_HUMAN 6TW2E 1.8 Active DFGin BLAminus in-in in-in V25 Type1 148 - 484 None X341,X342 0
Homo sapiens CLK1_HUMAN 6YTAA 2.3 Active DFGin BLAminus in-in in-in IYZ Type1 148 - 483 None None 0
Homo sapiens CLK1_HUMAN 6YTEC 2.3 Active DFGin BLAminus in-in in-in EAE Type1 148 - 484 None None 0
Homo sapiens CLK1_HUMAN 6YTIA 2.4 Active DFGin BLAminus in-in in-in 7A7 Type1 150 - 482 None None 0
Homo sapiens CLK1_HUMAN 6Z4ZA 2.07 Active DFGin BLAminus in-in in-in PQ5 Type1 148 - 482 None None 0
Homo sapiens CLK1_HUMAN 6Z4ZB 2.07 Active DFGin BLAminus in-in in-in PQ5 Type1 148 - 484 None None 0
Homo sapiens CLK1_HUMAN 6Z4ZC 2.07 Active DFGin BLAminus in-in in-in PQ5 Type1 148 - 482 None None 0
Homo sapiens CLK1_HUMAN 6Z50A 1.6 Inactive DFGin BLAminus in-out in-in Q7K Type1 149 - 481 None None 0
Homo sapiens CLK1_HUMAN 6ZLNA 1.7 Active DFGin BLAminus in-in in-in PKB Type1 148 - 484 None None 0
Homo sapiens CLK1_HUMAN 7AK3A 2.5 Active DFGin BLAminus in-in in-in RH8 Type1 148 - 483 None None 0
Homo sapiens CLK1_HUMAN 7OPGA 1.93 Active DFGin BLAminus in-in in-in 06N Type1 148 - 482 None None 0
Homo sapiens CLK1_HUMAN 7OPGB 1.93 Active DFGin BLAminus in-in in-in 06N Type1 148 - 483 None None 0
Homo sapiens CLK1_HUMAN 7OPGC 1.93 Active DFGin BLAminus in-in in-in 06N Type1 148 - 482 None None 0
Homo sapiens CLK1_HUMAN 8P04A 2.6 Active DFGin BLAminus in-in in-in WAK Type1 148 - 481 None None 6
Homo sapiens CLK1_HUMAN 8P08A 2.4 Inactive DFGin BLAminus in-in in-out WAZ Type1 148 - 481 None None 0
Homo sapiens CLK1_HUMAN 6FYOA 2.32 Active DFGin BLAminus in-in in-in EAQ Type1 148 - 481 None None 0
Homo sapiens CLK1_HUMAN 5X8IA 1.902 Active DFGin BLAminus in-in in-in SQZ Type1 154 - 481 R432A None 0
Homo sapiens CLK1_HUMAN 5X8IB 1.902 Active DFGin BLAminus in-in in-in SQZ Type1 155 - 481 R432A None 0
Homo sapiens CLK1_HUMAN 6KHDB 2.7 Active DFGin BLAminus in-in in-in 3NG Type1 149 - 482 None None 0
Homo sapiens CLK1_HUMAN 5J1WC 2.42 Inactive DFGin BLAminus in-in in-out 6FB 6FB Type1 Allosteric 148 - 483 None None 0
Homo sapiens CLK1_HUMAN 6YTGA 1.95 Active DFGin BLAminus in-in in-in KHC KHC Type1 Allosteric 148 - 483 None None 0
Homo sapiens CLK1_HUMAN 6R8JA 1.75 Active DFGin BLAminus in-in in-in JUW JUW Type1 Type1 152 - 481 None None 0
Homo sapiens CLK1_HUMAN 6KHDA 2.7 Inactive DFGin None in-in in-none 3NG Type1 149 - 481 None None 2
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AA 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AB 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AC 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AD 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AE 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AF 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AG 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AH 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AI 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AJ 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AK 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AL 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AM 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AN 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AO 2.6 Inactive DFGin BLAminus in-out in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AP 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0

CLK1 (Dual specificity protein kinase CLK1)

Group: CMGC
Total number of chains: 16
Spatial Dihedral Chains Representative
DFGin BLAminus 16 6Q2AA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AA 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AB 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AC 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AD 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AE 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AF 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AG 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AH 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AI 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AJ 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AK 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AL 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AM 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AN 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AO 2.6 Inactive DFGin BLAminus in-out in-in 5XH Type1 127 - 465 None None 0
Trypanosoma brucei brucei Q382U0_TRYB2 6Q2AP 2.6 Active DFGin BLAminus in-in in-in 5XH Type1 127 - 465 None None 0