CDK7 (Cyclin-dependent kinase 7)

Group: CMGC
Uniprot: CDK7_HUMAN
Domain boundary: 12 - 296


Total number of chains: 56
Spatial Dihedral Chains Representative
DFGin BLAminus 31 AF-P50613-K1A
DFGin BLAplus 1 8P4ZA
DFGin ABAminus 5 7ENC8
DFGin BLBplus 1 8P4ZB
DFGin None 16 7EGC8
None None 2 8PYRA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
7EGB8 3.3 Inactive DFGin ABAminus in-out in-in No_ligand No_ligand 10 - 312 None None 0
7ENC8 4.13 Inactive DFGin ABAminus in-out in-in No_ligand No_ligand 13 - 311 None None 0
7LBMe 4.8 Inactive DFGin ABAminus in-out in-in No_ligand No_ligand 10 - 312 None None 0
7NVR8 4.5 Inactive DFGin ABAminus in-out in-in No_ligand No_ligand 10 - 312 None None 0
6XBZJ 2.8 Inactive DFGin ABAminus in-out in-in AGS Type1 10 - 312 None X164 0
8R9SA 2.78 Active DFGin BLAminus in-in in-in PE3 PE3 YPK Allosteric Allosteric Type1 8 - 312 W132R,S164D,T170E None 9
AF-P50613-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 4 - 303 None None 0
8BVW8 4.0 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 13 - 311 None None 0
8P79J 1.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 10 - 310 None None 0
8R99A 1.81 Inactive DFGin BLAminus in-out in-in ANP Type1 10 - 311 W132R,S164D,T170E None 0
8R9AA 1.71 Active DFGin BLAminus in-in in-in I74 Type1 10 - 311 W132R,S164D,T170E None 0
8R9OA 2.22 Active DFGin BLAminus in-in in-in YN3 Type1 10 - 312 W132R,S164D,T170E None 10
8R9OB 2.22 Inactive DFGin BLAminus in-out in-in YN3 Type1 10 - 312 W132R,S164D,T170E None 5
8R9UA 1.937 Active DFGin BLAminus in-in in-in YNK Type1 10 - 311 W132R,S164D,T170E None 6
8R9UB 1.937 Active DFGin BLAminus in-in in-in YNK Type1 10 - 311 W132R,S164D,T170E None 6
8ORMJ 1.9 Active DFGin BLAminus in-in in-in V0G Type1 10 - 312 None None 0
8P6VJ 1.9 Active DFGin BLAminus in-in in-in I74 Type1 10 - 310 None None 0
8P6WJ 1.9 Active DFGin BLAminus in-in in-in X2H Type1 10 - 310 None None 0
8P6XJ 1.9 Active DFGin BLAminus in-in in-in NS9 Type1 10 - 310 None None 0
8P6YJ 1.9 Inactive DFGin BLAminus in-out in-in AGS Type1 10 - 310 None None 0
8P6ZJ 2.1 Active DFGin BLAminus in-in in-in X4L Type1 10 - 310 None None 0
8P70J 2.0 Active DFGin BLAminus in-in in-in X4Q Type1 10 - 310 None None 0
8P71J 2.0 Active DFGin BLAminus in-in in-in X4F Type1 10 - 310 None None 0
8P72J 1.9 Active DFGin BLAminus in-in in-in X2Z Type1 10 - 310 None None 0
8P74J 2.2 Active DFGin BLAminus in-in in-in X3Z Type1 10 - 310 None None 0
8P75J 2.0 Active DFGin BLAminus in-in in-in X3Z Type1 10 - 310 None None 0
8P76J 2.0 Active DFGin BLAminus in-in in-in X1W Type1 10 - 310 None None 0
8P77J 1.8 Inactive DFGin BLAminus in-out in-in I73 Type1 10 - 310 None None 0
8P78J 1.9 Active DFGin BLAminus in-in in-in 1QK Type1 10 - 310 None None 0
8PLZJ 1.9 Active DFGin BLAminus in-in in-in ZQ6 Type1 10 - 310 None None 0
8S0RJ 2.4 Active DFGin BLAminus in-in in-in A1H46 Type1 10 - 312 None None 0
8S0TJ 2.3 Active DFGin BLAminus in-in in-in YNK Type1 10 - 310 None None 4
8P7LJ 2.1 Inactive DFGin BLAminus in-out in-in WD9 Type1 10 - 311 None None 7
7B5OJ 2.5 Active DFGin BLAminus in-in in-in I74 Type1 10 - 311 None None 0
7B5QJ 2.5 Active DFGin BLAminus in-in in-in I74 Type1 10 - 311 None None 0
8P73J 2.0 Active DFGin BLAminus in-in in-in X50 X58 Type1 Type1 10 - 310 None None 0
8P4ZA 2.75 Inactive DFGin BLAplus out-out out-out WZ8 Type1 11 - 310 None None 13
8P4ZB 2.75 Inactive DFGin BLBplus out-out out-out WZ8 Type1 10 - 310 None None 12
8R9SB 2.78 Inactive DFGin None in-in in-in PE3 PE3 YPK Allosteric Allosteric Type1 9 - 312 W132R,S164D,T170E None 9
6O9L8 7.2 Inactive DFGin None out-out in-in No_ligand No_ligand 13 - 311 None None 0
7EGC8 3.9 Inactive DFGin None in-out in-in No_ligand No_ligand 13 - 310 None None 0
7ENA8 4.07 Inactive DFGin None in-out in-in No_ligand No_ligand 13 - 311 None None 0
8BYQ8 4.1 Inactive DFGin None in-in in-in No_ligand No_ligand 13 - 310 None None 0
8GXQHI 5.04 Inactive DFGin None in-none in-in No_ligand No_ligand 13 - 311 K41A None 0
8GXSHI 4.16 Inactive DFGin None in-none in-in No_ligand No_ligand 13 - 311 K41A None 0
1UA2A 3.02 Inactive DFGin None out-out out-out ATP Type1 13 - 311 None X170 0
1UA2B 3.02 Inactive DFGin None out-out out-out ATP Type1 13 - 311 None X170 0
1UA2C 3.02 Inactive DFGin None out-out out-out ATP Type1 13 - 311 None X170 0
1UA2D 3.02 Inactive DFGin None out-out out-out ATP Type1 13 - 311 None X170 0
6XD3J 3.3 Inactive DFGin None in-out in-in V0G Type1 10 - 312 None X164 0
8R9BA 2.21 Inactive DFGin None out-out out-out ANP Type1 1 - 311 S164D,T170E None 0
8R9BB 2.21 Inactive DFGin None out-out out-out ANP Type1 3 - 310 S164D,T170E None 0
8R9BC 2.21 Inactive DFGin None out-out out-out ANP Type1 8 - 311 S164D,T170E None 12
8R9BD 2.21 Inactive DFGin None out-out out-out ANP Type1 9 - 311 S164D,T170E None 10
8PYRA 2.15 Inactive None None none-none in-in No_ligand No_ligand 46 - 311 None X164,X170 0
8PYRE 2.15 Inactive None None none-none in-in No_ligand No_ligand 51 - 310 None X164,X170 0

CDK7 (Cyclin-dependent kinase 7)

Group: CMGC
Total number of chains: 60
Spatial Dihedral Chains Representative
DFGin BLAminus 31 AF-P50613-K1A
DFGin BLAplus 1 8P4ZA
DFGin ABAminus 7 6Z3UB
DFGin BLBplus 1 8P4ZB
DFGin None 18 6Z4XB
None None 2 8PYRA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Chaetomium thermophilum G0SFC6_CHATD 6Z3UB 2.6 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 78 - 399 None None 0
Chaetomium thermophilum G0SFC6_CHATD 6Z3UE 2.6 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 77 - 399 None None 0
Chaetomium thermophilum G0SFC6_CHATD 6Z4XB 2.98 Inactive DFGin None in-out in-in AGS Type1 78 - 399 None None 0
Chaetomium thermophilum G0SFC6_CHATD 6Z4XE 2.98 Inactive DFGin None in-out in-in AGS Type1 77 - 399 None None 0
Homo sapiens CDK7_HUMAN 7EGB8 3.3 Inactive DFGin ABAminus in-out in-in No_ligand No_ligand 10 - 312 None None 0
Homo sapiens CDK7_HUMAN 7ENC8 4.13 Inactive DFGin ABAminus in-out in-in No_ligand No_ligand 13 - 311 None None 0
Homo sapiens CDK7_HUMAN 7LBMe 4.8 Inactive DFGin ABAminus in-out in-in No_ligand No_ligand 10 - 312 None None 0
Homo sapiens CDK7_HUMAN 7NVR8 4.5 Inactive DFGin ABAminus in-out in-in No_ligand No_ligand 10 - 312 None None 0
Homo sapiens CDK7_HUMAN 6XBZJ 2.8 Inactive DFGin ABAminus in-out in-in AGS Type1 10 - 312 None X164 0
Homo sapiens CDK7_HUMAN 8R9SA 2.78 Active DFGin BLAminus in-in in-in PE3 PE3 YPK Allosteric Allosteric Type1 8 - 312 W132R,S164D,T170E None 9
Homo sapiens CDK7_HUMAN AF-P50613-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 4 - 303 None None 0
Homo sapiens CDK7_HUMAN 8BVW8 4.0 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 13 - 311 None None 0
Homo sapiens CDK7_HUMAN 8P79J 1.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8R99A 1.81 Inactive DFGin BLAminus in-out in-in ANP Type1 10 - 311 W132R,S164D,T170E None 0
Homo sapiens CDK7_HUMAN 8R9AA 1.71 Active DFGin BLAminus in-in in-in I74 Type1 10 - 311 W132R,S164D,T170E None 0
Homo sapiens CDK7_HUMAN 8R9OA 2.22 Active DFGin BLAminus in-in in-in YN3 Type1 10 - 312 W132R,S164D,T170E None 10
Homo sapiens CDK7_HUMAN 8R9OB 2.22 Inactive DFGin BLAminus in-out in-in YN3 Type1 10 - 312 W132R,S164D,T170E None 5
Homo sapiens CDK7_HUMAN 8R9UA 1.937 Active DFGin BLAminus in-in in-in YNK Type1 10 - 311 W132R,S164D,T170E None 6
Homo sapiens CDK7_HUMAN 8R9UB 1.937 Active DFGin BLAminus in-in in-in YNK Type1 10 - 311 W132R,S164D,T170E None 6
Homo sapiens CDK7_HUMAN 8ORMJ 1.9 Active DFGin BLAminus in-in in-in V0G Type1 10 - 312 None None 0
Homo sapiens CDK7_HUMAN 8P6VJ 1.9 Active DFGin BLAminus in-in in-in I74 Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8P6WJ 1.9 Active DFGin BLAminus in-in in-in X2H Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8P6XJ 1.9 Active DFGin BLAminus in-in in-in NS9 Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8P6YJ 1.9 Inactive DFGin BLAminus in-out in-in AGS Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8P6ZJ 2.1 Active DFGin BLAminus in-in in-in X4L Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8P70J 2.0 Active DFGin BLAminus in-in in-in X4Q Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8P71J 2.0 Active DFGin BLAminus in-in in-in X4F Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8P72J 1.9 Active DFGin BLAminus in-in in-in X2Z Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8P74J 2.2 Active DFGin BLAminus in-in in-in X3Z Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8P75J 2.0 Active DFGin BLAminus in-in in-in X3Z Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8P76J 2.0 Active DFGin BLAminus in-in in-in X1W Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8P77J 1.8 Inactive DFGin BLAminus in-out in-in I73 Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8P78J 1.9 Active DFGin BLAminus in-in in-in 1QK Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8PLZJ 1.9 Active DFGin BLAminus in-in in-in ZQ6 Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8S0RJ 2.4 Active DFGin BLAminus in-in in-in A1H46 Type1 10 - 312 None None 0
Homo sapiens CDK7_HUMAN 8S0TJ 2.3 Active DFGin BLAminus in-in in-in YNK Type1 10 - 310 None None 4
Homo sapiens CDK7_HUMAN 8P7LJ 2.1 Inactive DFGin BLAminus in-out in-in WD9 Type1 10 - 311 None None 7
Homo sapiens CDK7_HUMAN 7B5OJ 2.5 Active DFGin BLAminus in-in in-in I74 Type1 10 - 311 None None 0
Homo sapiens CDK7_HUMAN 7B5QJ 2.5 Active DFGin BLAminus in-in in-in I74 Type1 10 - 311 None None 0
Homo sapiens CDK7_HUMAN 8P73J 2.0 Active DFGin BLAminus in-in in-in X50 X58 Type1 Type1 10 - 310 None None 0
Homo sapiens CDK7_HUMAN 8P4ZA 2.75 Inactive DFGin BLAplus out-out out-out WZ8 Type1 11 - 310 None None 13
Homo sapiens CDK7_HUMAN 8P4ZB 2.75 Inactive DFGin BLBplus out-out out-out WZ8 Type1 10 - 310 None None 12
Homo sapiens CDK7_HUMAN 8R9SB 2.78 Inactive DFGin None in-in in-in PE3 PE3 YPK Allosteric Allosteric Type1 9 - 312 W132R,S164D,T170E None 9
Homo sapiens CDK7_HUMAN 6O9L8 7.2 Inactive DFGin None out-out in-in No_ligand No_ligand 13 - 311 None None 0
Homo sapiens CDK7_HUMAN 7EGC8 3.9 Inactive DFGin None in-out in-in No_ligand No_ligand 13 - 310 None None 0
Homo sapiens CDK7_HUMAN 7ENA8 4.07 Inactive DFGin None in-out in-in No_ligand No_ligand 13 - 311 None None 0
Homo sapiens CDK7_HUMAN 8BYQ8 4.1 Inactive DFGin None in-in in-in No_ligand No_ligand 13 - 310 None None 0
Homo sapiens CDK7_HUMAN 8GXQHI 5.04 Inactive DFGin None in-none in-in No_ligand No_ligand 13 - 311 K41A None 0
Homo sapiens CDK7_HUMAN 8GXSHI 4.16 Inactive DFGin None in-none in-in No_ligand No_ligand 13 - 311 K41A None 0
Homo sapiens CDK7_HUMAN 1UA2A 3.02 Inactive DFGin None out-out out-out ATP Type1 13 - 311 None X170 0
Homo sapiens CDK7_HUMAN 1UA2B 3.02 Inactive DFGin None out-out out-out ATP Type1 13 - 311 None X170 0
Homo sapiens CDK7_HUMAN 1UA2C 3.02 Inactive DFGin None out-out out-out ATP Type1 13 - 311 None X170 0
Homo sapiens CDK7_HUMAN 1UA2D 3.02 Inactive DFGin None out-out out-out ATP Type1 13 - 311 None X170 0
Homo sapiens CDK7_HUMAN 6XD3J 3.3 Inactive DFGin None in-out in-in V0G Type1 10 - 312 None X164 0
Homo sapiens CDK7_HUMAN 8R9BA 2.21 Inactive DFGin None out-out out-out ANP Type1 1 - 311 S164D,T170E None 0
Homo sapiens CDK7_HUMAN 8R9BB 2.21 Inactive DFGin None out-out out-out ANP Type1 3 - 310 S164D,T170E None 0
Homo sapiens CDK7_HUMAN 8R9BC 2.21 Inactive DFGin None out-out out-out ANP Type1 8 - 311 S164D,T170E None 12
Homo sapiens CDK7_HUMAN 8R9BD 2.21 Inactive DFGin None out-out out-out ANP Type1 9 - 311 S164D,T170E None 10
Homo sapiens CDK7_HUMAN 8PYRA 2.15 Inactive None None none-none in-in No_ligand No_ligand 46 - 311 None X164,X170 0
Homo sapiens CDK7_HUMAN 8PYRE 2.15 Inactive None None none-none in-in No_ligand No_ligand 51 - 310 None X164,X170 0

CDK7 (Cyclin-dependent kinase 7)

Group: CMGC
Total number of chains: 4
Spatial Dihedral Chains Representative
DFGin ABAminus 2 6Z3UB
DFGin None 2 6Z4XB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Chaetomium thermophilum G0SFC6_CHATD 6Z3UB 2.6 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 78 - 399 None None 0
Chaetomium thermophilum G0SFC6_CHATD 6Z3UE 2.6 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 77 - 399 None None 0
Chaetomium thermophilum G0SFC6_CHATD 6Z4XB 2.98 Inactive DFGin None in-out in-in AGS Type1 78 - 399 None None 0
Chaetomium thermophilum G0SFC6_CHATD 6Z4XE 2.98 Inactive DFGin None in-out in-in AGS Type1 77 - 399 None None 0