AAK1 (AP2-associated protein kinase 1)

Group: OTHER
Uniprot: AAK1_HUMAN
Domain boundary: 46 - 313


Total number of chains: 10
Spatial Dihedral Chains Representative
DFGin BLAminus 10 AF-Q2M2I8-K1A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q2M2I8-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 38 - 321 None None 0
4WSQA 1.95 Active DFGin BLAminus in-in in-in KSA Type1 29 - 345 None None 0
4WSQB 1.95 Active DFGin BLAminus in-in in-in KSA Type1 33 - 342 None None 0
8GMCA 2.5 Active DFGin BLAminus in-in in-in YFV Type1 34 - 330 None None 0
8GMCB 2.5 Active DFGin BLAminus in-in in-in YFV Type1 31 - 330 None None 0
8GMDA 2.2 Active DFGin BLAminus in-in in-in ZRR Type1 34 - 329 None None 0
8GMDB 2.2 Active DFGin BLAminus in-in in-in ZRR Type1 29 - 330 None None 0
5L4QA 1.97 Active DFGin BLAminus in-in in-in LKB Type1 33 - 335 None None 0
5L4QB 1.97 Active DFGin BLAminus in-in in-in LKB Type1 33 - 333 None None 0
5TE0A 1.9 Active DFGin BLAminus in-in in-in XIN Type1 27 - 345 None None 0

AAK1 (AP2-associated protein kinase 1)

Group: OTHER
Total number of chains: 20
Spatial Dihedral Chains Representative
DFGin BLAminus 19 AF-Q2M2I8-K1A
DFGin ABAminus 1 7LVIA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens AAK1_HUMAN AF-Q2M2I8-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 38 - 321 None None 0
Homo sapiens AAK1_HUMAN 4WSQA 1.95 Active DFGin BLAminus in-in in-in KSA Type1 29 - 345 None None 0
Homo sapiens AAK1_HUMAN 4WSQB 1.95 Active DFGin BLAminus in-in in-in KSA Type1 33 - 342 None None 0
Homo sapiens AAK1_HUMAN 8GMCA 2.5 Active DFGin BLAminus in-in in-in YFV Type1 34 - 330 None None 0
Homo sapiens AAK1_HUMAN 8GMCB 2.5 Active DFGin BLAminus in-in in-in YFV Type1 31 - 330 None None 0
Homo sapiens AAK1_HUMAN 8GMDA 2.2 Active DFGin BLAminus in-in in-in ZRR Type1 34 - 329 None None 0
Homo sapiens AAK1_HUMAN 8GMDB 2.2 Active DFGin BLAminus in-in in-in ZRR Type1 29 - 330 None None 0
Homo sapiens AAK1_HUMAN 5L4QA 1.97 Active DFGin BLAminus in-in in-in LKB Type1 33 - 335 None None 0
Homo sapiens AAK1_HUMAN 5L4QB 1.97 Active DFGin BLAminus in-in in-in LKB Type1 33 - 333 None None 0
Homo sapiens AAK1_HUMAN 5TE0A 1.9 Active DFGin BLAminus in-in in-in XIN Type1 27 - 345 None None 0
Mus musculus AAK1_MOUSE 7LVIA 2.2 Inactive DFGin ABAminus in-in in-in YFY Type1 34 - 330 None None 0
Mus musculus AAK1_MOUSE 7LVHA 2.65 Active DFGin BLAminus in-in in-in YFS Type1 34 - 328 None None 2
Mus musculus AAK1_MOUSE 7LVHB 2.65 Active DFGin BLAminus in-in in-in YFV Type1 35 - 329 None None 2
Mus musculus AAK1_MOUSE 7LVIB 2.2 Active DFGin BLAminus in-in in-in YFV Type1 35 - 330 None None 0
Mus musculus AAK1_MOUSE 7RJ6A 2.132 Active DFGin BLAminus in-in in-in YFV Type1 26 - 330 None None 0
Mus musculus AAK1_MOUSE 7RJ6B 2.132 Active DFGin BLAminus in-in in-in 5OI Type1 32 - 330 None None 0
Mus musculus AAK1_MOUSE 7RJ7A 2.124 Active DFGin BLAminus in-in in-in 5P6 Type1 26 - 330 None None 0
Mus musculus AAK1_MOUSE 7RJ7B 2.124 Active DFGin BLAminus in-in in-in 5P6 Type1 31 - 330 None None 0
Mus musculus AAK1_MOUSE 7RJ8A 2.59 Active DFGin BLAminus in-in in-in 5QI PG6 Type1 Allosteric 33 - 329 None None 0
Mus musculus AAK1_MOUSE 7RJ8B 2.59 Active DFGin BLAminus in-in in-in YFV PG6 Type1 Allosteric 26 - 330 None None 0

AAK1 (AP2-associated protein kinase 1)

Group: OTHER
Total number of chains: 10
Spatial Dihedral Chains Representative
DFGin BLAminus 9 7RJ7B
DFGin ABAminus 1 7LVIA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Mus musculus AAK1_MOUSE 7LVIA 2.2 Inactive DFGin ABAminus in-in in-in YFY Type1 34 - 330 None None 0
Mus musculus AAK1_MOUSE 7LVHA 2.65 Active DFGin BLAminus in-in in-in YFS Type1 34 - 328 None None 2
Mus musculus AAK1_MOUSE 7LVHB 2.65 Active DFGin BLAminus in-in in-in YFV Type1 35 - 329 None None 2
Mus musculus AAK1_MOUSE 7LVIB 2.2 Active DFGin BLAminus in-in in-in YFV Type1 35 - 330 None None 0
Mus musculus AAK1_MOUSE 7RJ6A 2.132 Active DFGin BLAminus in-in in-in YFV Type1 26 - 330 None None 0
Mus musculus AAK1_MOUSE 7RJ6B 2.132 Active DFGin BLAminus in-in in-in 5OI Type1 32 - 330 None None 0
Mus musculus AAK1_MOUSE 7RJ7A 2.124 Active DFGin BLAminus in-in in-in 5P6 Type1 26 - 330 None None 0
Mus musculus AAK1_MOUSE 7RJ7B 2.124 Active DFGin BLAminus in-in in-in 5P6 Type1 31 - 330 None None 0
Mus musculus AAK1_MOUSE 7RJ8A 2.59 Active DFGin BLAminus in-in in-in 5QI PG6 Type1 Allosteric 33 - 329 None None 0
Mus musculus AAK1_MOUSE 7RJ8B 2.59 Active DFGin BLAminus in-in in-in YFV PG6 Type1 Allosteric 26 - 330 None None 0