9Q32

RIPK1 (Receptor-interacting serine/threonine-protein kinase 1)
Group: TKL
Uniprot: RIPK1_HUMAN
Organism: Homo sapiens
Domain boundary: 17 - 287
Resolu: 2.49

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGout BBAminus out-out out-out A1CNV Type3 6 - 293 12
B Inactive DFGout BBAminus out-out out-none A1CNV Type3 8 - 294 18
C Inactive DFGout BBAminus out-out out-out A1CNV Type3 6 - 293 17
D Inactive DFGout BBAminus out-none out-out A1CNV Type3 8 - 294 19
Representative sequence - Chain D
8 18 28 38
gsmqpdmslN VIKMKSSDFL esaeldsggf gkVSLAFHRT
48 58 68 78
QGLMIMKTVy kgpncIEHNE ALLEEAKMMN RLRHSRVVKL
88 98 108 118
LGVIIEEGKY SLVMEYMEKG NLMHVLKAEM STPLSVKGRI
128 138 148 158
ILEIIEGMAY LHGKGVIHKD LKPENILVDN DFHIKIADLG
168 178 188 198
LASFKMWSKL nneehnelre vdgtakkngG TLYYMAPEHL
208 218 228 238
NDVNAKPTEK SDVYSFAVVL WAIFANKEPY ENAIAEQQLI
248 258 268 278
MAIKSGNRPD VDDITEYCPR EIISLMKLCW EANPEARPTF
288
PGIEEKFRPF YLSQLE
Lower-case residues are disordered in structure.
Mutations: C34A,C127A,C233A,C240A
Phosphorylation: None