PDB: 9AXA — 2 kinases

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% 9AXAC
DFGin BLBplus 2 50.0% 9AXAD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE MAP2K1 MP2K1_HUMAN 9AXAB Q02750 52 380 393.0 A1AHE:401 Type3 Inactive DFGin 6.8129 13.7682 BLBplus -157.46, 170.37 59.28, 64.98 -117.48, 165.11 40.29, 81.19 -81.1, 74.19 out-out out 15.4311 Saltbr-out 17.4099 HRD-in -75.24, -42.64 72.38, -11.77 out-out-out SNCooo out-out ActLoopNT-out 9.2081 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -68.37, -62.71 APE9-dihe-na 103.09, 102.94 APE8-dihe-out -88.38, -48.33 APE8-rot-out 62.02 APE67-dihe-out -122.1, 131.17 -98.78, 143.35 APE12-dist-out 16.6961 APE11-dist-out 18.1264 APE10-dist-out 22.8521 APE9-dist-out 12.4243 S218A,S222A None None EM 4.36 999.0 999.0 B 394.0 278.0 51 26 26 0 [[68, 361]] 1.0 9axa STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXAD Q02750 59 383 393.0 A1AHE:401 Type3 Inactive DFGin 6.1878 15.038 BLBplus -161.59, 167.64 63.71, 27.36 -77.56, 162.55 63.45, 90.49 -80.72, 76.54 out-out out 17.6128 Saltbr-out 18.7979 HRD-in -103.62, -49.66 71.76, -9.27 out-out-out SNCooo out-out ActLoopNT-out 9.7971 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na 56.39, -81.94 APE9-dihe-na 48.87, 69.85 APE8-dihe-out -71.23, -18.7 APE8-rot-out 181.91 APE67-dihe-out -127.48, 156.86 -129.99, 139.21 APE12-dist-out 19.1615 APE11-dist-out 16.676 APE10-dist-out 21.3744 APE9-dist-out 12.2717 S218A,S222A None None EM 4.36 999.0 999.0 D 394.0 275.0 50 26 26 0 [[68, 361]] 1.0 9axa STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
TKL RAF1 RAF1_HUMAN 9AXAA P04049 342 625 648.0 No_ligand No_ligand Inactive DFGin 7.2548 13.9989 BLAminus -139.05, -163.7 58.24, 64.96 -89.4, 29.46 290.36, 82.23 -69.56, -16.76 in-out in 9.18 Saltbr-out 8.4188 HRD-in -78.78, -32.03 70.97, -14.05 out-in-out SNCoio in-out ActLoopNT-in 3.116 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -130.3, -20.74 APE9-dihe-na -70.73, -178.58 APE8-dihe-in -67.69, 139.48 APE8-rot-in 293.88 APE67-dihe-in -69.75, -43.45 -74.78, -4.77 APE12-dist-in 12.0486 APE11-dist-in 9.617 APE10-dist-out 9.0441 APE9-dist-out 7.5911 Y340D,Y341D SEP621 SEP621 EM 4.36 999.0 999.0 A 563.0 273.0 11 30 25 5 [[349, 608]] 1.0 9axa TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 9AXAC P04049 341 625 648.0 No_ligand No_ligand Inactive DFGin 7.3924 14.9903 BLAminus -146.66, -157.9 56.49, 63.39 -91.79, 31.37 293.16, 80.76 -67.87, -25.57 in-out in 8.9755 Saltbr-out 10.0011 HRD-in -78.03, -41.77 71.76, -11.87 out-in-out SNCoio in-out ActLoopNT-in 2.7588 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 54.52, 48.67 APE9-dihe-na -119.18, -141.08 APE8-dihe-in -96.15, 129.35 APE8-rot-out 174.93 APE67-dihe-in -72.88, -14.72 -74.49, -3.91 APE12-dist-in 11.8542 APE11-dist-in 9.1816 APE10-dist-out 11.2816 APE9-dist-out 9.0508 Y340D,Y341D SEP621 SEP621 EM 4.36 999.0 999.0 C 563.0 275.0 10 30 30 0 [[349, 608]] 1.0 9axa TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase

PDB: 9AXA — 2 kinases

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% 9AXAC
DFGin BLBplus 2 50.0% 9AXAD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE MAP2K1 MP2K1_HUMAN 9AXAB Q02750 52 380 393.0 A1AHE:401 Type3 Inactive DFGin 6.8129 13.7682 BLBplus -157.46, 170.37 59.28, 64.98 -117.48, 165.11 40.29, 81.19 -81.1, 74.19 out-out out 15.4311 Saltbr-out 17.4099 HRD-in -75.24, -42.64 72.38, -11.77 out-out-out SNCooo out-out ActLoopNT-out 9.2081 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -68.37, -62.71 APE9-dihe-na 103.09, 102.94 APE8-dihe-out -88.38, -48.33 APE8-rot-out 62.02 APE67-dihe-out -122.1, 131.17 -98.78, 143.35 APE12-dist-out 16.6961 APE11-dist-out 18.1264 APE10-dist-out 22.8521 APE9-dist-out 12.4243 S218A,S222A None None EM 4.36 999.0 999.0 B 394.0 278.0 51 26 26 0 [[68, 361]] 1.0 9axa Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXAD Q02750 59 383 393.0 A1AHE:401 Type3 Inactive DFGin 6.1878 15.038 BLBplus -161.59, 167.64 63.71, 27.36 -77.56, 162.55 63.45, 90.49 -80.72, 76.54 out-out out 17.6128 Saltbr-out 18.7979 HRD-in -103.62, -49.66 71.76, -9.27 out-out-out SNCooo out-out ActLoopNT-out 9.7971 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na 56.39, -81.94 APE9-dihe-na 48.87, 69.85 APE8-dihe-out -71.23, -18.7 APE8-rot-out 181.91 APE67-dihe-out -127.48, 156.86 -129.99, 139.21 APE12-dist-out 19.1615 APE11-dist-out 16.676 APE10-dist-out 21.3744 APE9-dist-out 12.2717 S218A,S222A None None EM 4.36 999.0 999.0 D 394.0 275.0 50 26 26 0 [[68, 361]] 1.0 9axa Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
TKL RAF1 RAF1_HUMAN 9AXAA P04049 342 625 648.0 No_ligand No_ligand Inactive DFGin 7.2548 13.9989 BLAminus -139.05, -163.7 58.24, 64.96 -89.4, 29.46 290.36, 82.23 -69.56, -16.76 in-out in 9.18 Saltbr-out 8.4188 HRD-in -78.78, -32.03 70.97, -14.05 out-in-out SNCoio in-out ActLoopNT-in 3.116 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -130.3, -20.74 APE9-dihe-na -70.73, -178.58 APE8-dihe-in -67.69, 139.48 APE8-rot-in 293.88 APE67-dihe-in -69.75, -43.45 -74.78, -4.77 APE12-dist-in 12.0486 APE11-dist-in 9.617 APE10-dist-out 9.0441 APE9-dist-out 7.5911 Y340D,Y341D SEP621 SEP621 EM 4.36 999.0 999.0 A 563.0 273.0 11 30 25 5 [[349, 608]] 1.0 9axa Homo sapiens TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 9AXAC P04049 341 625 648.0 No_ligand No_ligand Inactive DFGin 7.3924 14.9903 BLAminus -146.66, -157.9 56.49, 63.39 -91.79, 31.37 293.16, 80.76 -67.87, -25.57 in-out in 8.9755 Saltbr-out 10.0011 HRD-in -78.03, -41.77 71.76, -11.87 out-in-out SNCoio in-out ActLoopNT-in 2.7588 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 54.52, 48.67 APE9-dihe-na -119.18, -141.08 APE8-dihe-in -96.15, 129.35 APE8-rot-out 174.93 APE67-dihe-in -72.88, -14.72 -74.49, -3.91 APE12-dist-in 11.8542 APE11-dist-in 9.1816 APE10-dist-out 11.2816 APE9-dist-out 9.0508 Y340D,Y341D SEP621 SEP621 EM 4.36 999.0 999.0 C 563.0 275.0 10 30 30 0 [[349, 608]] 1.0 9axa Homo sapiens TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase

PDB: 9AXA — 2 kinases

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name