Ligand: QOP (Tovorafenib, Ojemda)

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 4 100.0% 8F7OB
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRAF BRAF_HUMAN 6V34A P15056 449 721 766.0 QOP:60801 Type2 Inactive DFGout 12.434 11.575 BBAminus -154.0, -169.02 -128.32, 93.65 -90.71, 10.51 309.15, 147.81 -68.37, 132.98 in-in in 9.086 Saltbr-in 2.538 HRD-in -69.77, -32.09 68.47, -18.7 in-out-out SNCioo out-out ActLoopNT-out 14.574 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 76.8 APE9-dihe-na -77.41, 65.97 APE8-dihe-in -153.14, 51.16 APE8-rot-in 295.33 APE67-dihe-in -64.54, -20.97 -83.49, -26.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.524 APE9-dist-out 11.638 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 3.15 0.257 0.286 A 283 254 19 0 0 14 [[457, 716]] 1.0 6v34 TKL_BRAF_HUMAN TKL 4.9e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6V34B P15056 449 721 766.0 QOP:60801 Type2 Inactive DFGout 12.56 11.92 BBAminus -154.71, -167.6 -127.21, 92.8 -91.69, -108.51 309.26, 147.08 122.27, 999.0 in-in in 9.301 Saltbr-in 2.891 HRD-in -70.04, -32.52 68.23, -18.05 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.85, -18.83 999.0, -26.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 3.15 0.257 0.286 B 283 247 26 0 0 20 [[457, 716]] 1.0 6v34 TKL_BRAF_HUMAN TKL 4.9e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8F7OA P15056 449 723 766.0 QOP:801 Type2 Inactive DFGout 12.249 12.005 BBAminus -159.37, -168.95 -123.81, 84.53 -83.54, -89.81 307.46, 148.61 127.38, -72.17 in-in in 8.972 Saltbr-in 2.449 HRD-in -72.55, -36.43 67.7, -16.13 in-out-out SNCioo out-out ActLoopNT-out 20.564 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na 65.25, -64.98 APE9-dihe-na -63.4, 3.38 APE8-dihe-out -60.69, 15.08 APE8-rot-out 16.0 APE67-dihe-in -61.67, -17.82 -103.11, -29.37 APE12-dist-in 11.837 APE11-dist-in 9.427 APE10-dist-out 14.448 APE9-dist-out 13.325 None None None XRAY 3.54 0.221 0.269 A 283 263 12 0 0 12 [[457, 716]] 1.0 8f7o TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8F7OB P15056 449 722 766.0 QOP:801 Type2 Inactive DFGout 12.526 11.094 BBAminus -157.64, -171.1 -125.72, 86.17 -82.43, 36.51 307.61, 97.24 -67.66, 176.06 in-in in 8.823 Saltbr-in 2.519 HRD-in -71.26, -35.39 67.81, -16.97 in-out-out SNCioo out-out ActLoopNT-out 13.331 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -143.78, -76.44 APE9-dihe-na -71.8, -5.6 APE8-dihe-out -117.21, 21.56 APE8-rot-in 305.57 APE67-dihe-in -66.7, -20.49 -89.8, -34.59 APE12-dist-out 21.596 APE11-dist-out 24.172 APE10-dist-out 26.848 APE9-dist-out 27.611 None None None XRAY 3.54 0.221 0.269 B 283 263 11 0 0 11 [[457, 716]] 1.0 8f7o TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf

Ligand: QOP (Tovorafenib, Ojemda)

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 4 100.0% 8F7OB
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRAF BRAF_HUMAN 6V34A P15056 449 721 766.0 QOP:60801 Type2 Inactive DFGout 12.434 11.575 BBAminus -154.0, -169.02 -128.32, 93.65 -90.71, 10.51 309.15, 147.81 -68.37, 132.98 in-in in 9.086 Saltbr-in 2.538 HRD-in -69.77, -32.09 68.47, -18.7 in-out-out SNCioo out-out ActLoopNT-out 14.574 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 76.8 APE9-dihe-na -77.41, 65.97 APE8-dihe-in -153.14, 51.16 APE8-rot-in 295.33 APE67-dihe-in -64.54, -20.97 -83.49, -26.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.524 APE9-dist-out 11.638 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 3.15 0.257 0.286 A 283 254 19 0 0 14 [[457, 716]] 1.0 6v34 Homo sapiens TKL_BRAF_HUMAN TKL 4.9e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6V34B P15056 449 721 766.0 QOP:60801 Type2 Inactive DFGout 12.56 11.92 BBAminus -154.71, -167.6 -127.21, 92.8 -91.69, -108.51 309.26, 147.08 122.27, 999.0 in-in in 9.301 Saltbr-in 2.891 HRD-in -70.04, -32.52 68.23, -18.05 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.85, -18.83 999.0, -26.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 3.15 0.257 0.286 B 283 247 26 0 0 20 [[457, 716]] 1.0 6v34 Homo sapiens TKL_BRAF_HUMAN TKL 4.9e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8F7OA P15056 449 723 766.0 QOP:801 Type2 Inactive DFGout 12.249 12.005 BBAminus -159.37, -168.95 -123.81, 84.53 -83.54, -89.81 307.46, 148.61 127.38, -72.17 in-in in 8.972 Saltbr-in 2.449 HRD-in -72.55, -36.43 67.7, -16.13 in-out-out SNCioo out-out ActLoopNT-out 20.564 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na 65.25, -64.98 APE9-dihe-na -63.4, 3.38 APE8-dihe-out -60.69, 15.08 APE8-rot-out 16.0 APE67-dihe-in -61.67, -17.82 -103.11, -29.37 APE12-dist-in 11.837 APE11-dist-in 9.427 APE10-dist-out 14.448 APE9-dist-out 13.325 None None None XRAY 3.54 0.221 0.269 A 283 263 12 0 0 12 [[457, 716]] 1.0 8f7o Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8F7OB P15056 449 722 766.0 QOP:801 Type2 Inactive DFGout 12.526 11.094 BBAminus -157.64, -171.1 -125.72, 86.17 -82.43, 36.51 307.61, 97.24 -67.66, 176.06 in-in in 8.823 Saltbr-in 2.519 HRD-in -71.26, -35.39 67.81, -16.97 in-out-out SNCioo out-out ActLoopNT-out 13.331 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -143.78, -76.44 APE9-dihe-na -71.8, -5.6 APE8-dihe-out -117.21, 21.56 APE8-rot-in 305.57 APE67-dihe-in -66.7, -20.49 -89.8, -34.59 APE12-dist-out 21.596 APE11-dist-out 24.172 APE10-dist-out 26.848 APE9-dist-out 27.611 None None None XRAY 3.54 0.221 0.269 B 283 263 11 0 0 11 [[457, 716]] 1.0 8f7o Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf

Ligand: QOP (Tovorafenib, Ojemda)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name