Ligand: PE5

Total number of chains: 8
Active chains: 8
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 100.0% 8HV6A
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Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR EGFR EGFR_HUMAN 8HV4A 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, MWU Allosteric, Type1 696 - 1020 0 None E865A,E866A,K867A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8HV6A 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, N86 Allosteric, Type1 696 - 1020 0 None E865A,E866A,K867A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8HV7A 2.69 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, N8O Allosteric, Type1 696 - 1019 0 None E865A,E866A,K867A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8HV8A 2.4 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, N99 Allosteric, Type1 696 - 1019 0 None C797S,E865A,E866A,K867A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8HV9A 2.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, N9L Allosteric, Type1 696 - 1019 0 None E865A,E866A,K867A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8HV1A 2.4 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, N6N Allosteric, Type1 696 - 1019 0 None E865A,E866A,K867A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8HV3A 2.4 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, MWU Allosteric, Type1 696 - 1020 0 None E865A,E866A,K867A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8HV5A 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, N7C Allosteric, Type1 696 - 1019 0 None E865A,E866A,K867A Epidermal growth factor receptor

Ligand: PE5

Total number of chains: 8
Active chains: 8
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 100.0% 8HV6A
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR EGFR EGFR_HUMAN 8HV4A 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, MWU Allosteric, Type1 696 - 1020 0 None E865A,E866A,K867A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8HV6A 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, N86 Allosteric, Type1 696 - 1020 0 None E865A,E866A,K867A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8HV7A 2.69 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, N8O Allosteric, Type1 696 - 1019 0 None E865A,E866A,K867A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8HV8A 2.4 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, N99 Allosteric, Type1 696 - 1019 0 None C797S,E865A,E866A,K867A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8HV9A 2.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, N9L Allosteric, Type1 696 - 1019 0 None E865A,E866A,K867A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8HV1A 2.4 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, N6N Allosteric, Type1 696 - 1019 0 None E865A,E866A,K867A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8HV3A 2.4 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, MWU Allosteric, Type1 696 - 1020 0 None E865A,E866A,K867A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8HV5A 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PE5, N7C Allosteric, Type1 696 - 1019 0 None E865A,E866A,K867A Epidermal growth factor receptor Homo sapiens

Ligand: PE5

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
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Hover over column headers for tooltip help

Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism