Ligand: P06 (Dabrafenib)

Total number of chains: 10
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 8 80.0% 5HIEB
DFGin None 2 20.0% 6V2UA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TKL BRAF BRAF_HUMAN 5HIEA 3.0 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnno P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5HIEB 3.0 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5HIEC 3.0 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaiii APEdist_nnoo P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5HIED 3.0 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaiii APEdist_nnoo P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4XV2A 2.5 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno P06 Type1.5_Back 449 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4XV2B 2.5 Inactive DFGin‑BLBminus in-out none-out nonTYR APEdihe_aaoii APEdist_nnno P06 Type1.5_Back 448 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5CSWB 2.66 Inactive DFGin‑BLBminus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn P06 Type1.5_Back 447 - 721 0 None R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6V2UB 3.78 Inactive DFGin‑BLBminus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn P06 Type1.5_Back 449 - 720 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5CSWA 2.66 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno P06 Type1.5_Back 449 - 721 0 None R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6V2UA 3.78 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiii APEdist_nnno P06 Type1.5_Back 449 - 721 0 None None Serine/threonine-protein kinase B-raf

Ligand: P06 (Dabrafenib)

Total number of chains: 10
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 8 80.0% 5HIEB
DFGin None 2 20.0% 6V2UA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL BRAF BRAF_HUMAN 5HIEA 3.0 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnno P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 5HIEB 3.0 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 5HIEC 3.0 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaiii APEdist_nnoo P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 5HIED 3.0 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaiii APEdist_nnoo P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 4XV2A 2.5 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno P06 Type1.5_Back 449 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 4XV2B 2.5 Inactive DFGin‑BLBminus in-out none-out nonTYR APEdihe_aaoii APEdist_nnno P06 Type1.5_Back 448 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 5CSWB 2.66 Inactive DFGin‑BLBminus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn P06 Type1.5_Back 447 - 721 0 None R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 6V2UB 3.78 Inactive DFGin‑BLBminus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn P06 Type1.5_Back 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 5CSWA 2.66 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno P06 Type1.5_Back 449 - 721 0 None R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 6V2UA 3.78 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiii APEdist_nnno P06 Type1.5_Back 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens

Ligand: P06 (Dabrafenib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism