Ligand: LI

Total number of chains: 28
Active chains: 1
Total number of genes: 13
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 14 50.0% 8S17A
DFGout None 9 32.1% 4QRCA
DFGin BLAminus 3 10.7% 4DTKA
None None 2 7.1% 6TU9A
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK PIM1 PIM1_HUMAN 4DTKA P11309 33 305 313.0 7LI:408 Type1 Active DFGin 6.142 14.661 BLAminus -128.39, 173.69 63.23, 87.87 -95.85, 17.29 285.67, 80.15 -64.1, -18.22 in-in in 8.861 Saltbr-in 2.588 HRD-na-A -66.25, -50.01 70.2, 5.45 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.52, 26.77 APE9-dihe-na -86.23, -154.0 APE8-dihe-in -89.22, 120.59 APE8-rot-in 306.1 APE67-dihe-in -65.85, -11.4 -53.32, -45.84 APE12-dist-in 9.701 APE11-dist-in 8.585 APE10-dist-in 5.474 APE9-dist-in 3.692 None None None XRAY 1.86 0.166 0.182 A 276 273 0 0 0 0 [[38, 290]] 1.0 4dtk CAMK_PIM1_HUMAN CAMK 2.5e-65 226.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CMGC DYRK1A DYR1A_HUMAN 7O7KA Q13627 134 480 763.0 6ZV:803,LI:813 Type1,Allosteric Inactive DFGin 7.479 14.978 BLAminus -123.84, 172.32 71.95, 80.41 -97.61, 20.16 282.45, 81.55 -75.41, -18.82 in-in in 8.732 Saltbr-in 2.569 HRD-in -66.95, -44.76 74.49, -2.2 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.45, 171.41 APE9-dihe-na 76.66, 152.25 APE8-dihe-in -71.23, 142.04 APE8-rot-out 204.57 APE67-dihe-in -61.2, -25.53 -57.62, -46.09 APE12-dist-in 13.826 APE11-dist-in 12.396 APE10-dist-in 7.934 APE9-dist-in 3.209 None PTR321 PTR321 XRAY 1.82 0.179 0.205 A 361 345 2 0 0 0 [[159, 479]] 1.0 7o7k CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7O7KB Q13627 133 480 763.0 6ZV:504,LI:516 Type1,Allosteric Inactive DFGin 7.549 15.002 BLAminus -123.44, 173.38 69.65, 80.66 -97.78, 19.84 280.19, 88.12 -76.56, -16.84 in-in in 8.721 Saltbr-in 2.45 HRD-in -66.14, -44.61 73.06, -2.94 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -122.41, 168.28 APE9-dihe-na 77.46, 151.66 APE8-dihe-in -70.04, 138.71 APE8-rot-out 178.34 APE67-dihe-in -60.28, -25.12 -56.13, -47.11 APE12-dist-in 13.885 APE11-dist-in 12.364 APE10-dist-out 8.042 APE9-dist-in 3.108 None PTR321 PTR321 XRAY 1.82 0.179 0.205 B 361 345 3 0 0 0 [[159, 479]] 1.0 7o7k CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
STE MAP3K2 M3K2_HUMAN 9P6AA Q9Y2U5 351 617 619.0 0LI:701 Type2 Inactive DFGout 14.143 9.891 BBAminus -146.02, -172.59 -157.95, 116.33 -87.88, -36.33 294.81, 102.45 -88.54, 36.79 in-in in 8.458 Saltbr-in 2.594 HRD-in -76.59, -52.31 80.62, -19.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.17, -51.62 APE9-dihe-na -96.01, 162.48 APE8-dihe-in -81.48, 131.06 APE8-rot-out 69.69 APE67-dihe-in -67.88, -22.22 -92.28, 3.15 APE12-dist-out 20.682 APE11-dist-out 19.144 APE10-dist-out 14.309 APE9-dist-out 10.456 None None None XRAY 2.4 0.228 0.246 A 299 253 14 0 0 14 [[356, 616]] 1.0 9p6a STE_MAP3K2_HUMAN STE 1.9e-81 279.1 1 257 257 500 501 502 504 506 385 406 410 480 482 481 483 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2
STE MAP3K2 M3K2_HUMAN 9P6AB Q9Y2U5 347 618 619.0 0LI:701 Type2 Inactive DFGout 13.802 9.756 None -145.97, -173.02 -157.2, 114.58 -90.61, 158.12 297.06, 102.49 67.12, -99.7 in-in in 8.631 Saltbr-in 2.727 HRD-in -74.0, -48.74 85.04, -22.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -168.99 APE9-dihe-na -96.92, -27.66 APE8-dihe-in -82.09, 127.1 APE8-rot-out 70.19 APE67-dihe-in -70.58, -23.59 -96.42, -0.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.637 APE9-dist-out 10.787 None None None XRAY 2.4 0.228 0.246 B 299 247 25 0 0 16 [[356, 616]] 1.0 9p6a STE_MAP3K2_HUMAN STE 1.9e-81 279.1 1 257 257 500 501 502 504 506 385 406 410 480 482 481 483 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2
TKL BRAF BRAF_HUMAN 6P3DA P15056 448 721 766.0 0LI:61001 Type2 Inactive DFGout 12.35 10.905 BBAminus -138.54, -166.92 -135.05, 80.45 -80.66, -37.84 293.17, 97.28 81.0, 10.25 in-in in 8.665 Saltbr-in 2.997 HRD-in -65.6, -55.77 77.59, -19.55 in-out-out SNCioo out-out ActLoopNT-out 19.945 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -19.82 APE9-dihe-na 76.62, -63.3 APE8-dihe-out -51.89, -23.77 APE8-rot-out 78.9 APE67-dihe-in -55.73, -23.59 -56.01, -24.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.7 APE9-dist-out 11.871 None None None XRAY 2.11 0.188 0.245 A 297 261 13 0 0 13 [[457, 716]] 1.0 6p3d TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 6EG9A Q9NWZ3 164 459 460.0 0LI:501 Type2 Inactive DFGout 14.071 10.716 None -127.45, 167.3 -138.69, 101.47 -85.85, 140.23 309.7, 100.41 -43.19, 999.0 in-out in 9.027 Saltbr-out 6.646 HRD-in -71.51, -48.43 70.86, -5.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 6.91 APE9-dihe-na 158.59, -165.8 APE8-dihe-in -114.99, 116.82 APE8-rot-in 299.55 APE67-dihe-in -67.65, -20.43 -63.19, -29.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.972 None None None XRAY 2.414 0.224 0.249 A 312 276 20 0 0 17 [[183, 456]] 1.0 6eg9 TKL_IRAK4_HUMAN TKL 4.6e-84 288.0 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EG9B Q9NWZ3 165 459 460.0 0LI:501 Type2 Inactive DFGout 14.244 9.395 None -135.81, 174.82 -152.29, 126.78 -163.75, 999.0 33.58, 60.29 999.0, 999.0 in-in in 8.979 Saltbr-in 3.09 HRD-in -69.81, -51.27 77.39, -7.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 146.5 APE9-dihe-na 95.5, 175.38 APE8-dihe-in -117.78, 118.94 APE8-rot-in 307.93 APE67-dihe-in -67.02, -18.64 -61.22, -30.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.63 None None None XRAY 2.414 0.224 0.249 B 312 274 21 0 0 18 [[183, 456]] 1.0 6eg9 TKL_IRAK4_HUMAN TKL 4.6e-84 288.0 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL LRRK2 LRRK2_HUMAN 8U8AB Q5S007 558 2526 2527.0 0LI:2601 Type2 Inactive DFGout 14.859 10.845 BBAminus -150.37, 144.32 -124.19, 97.68 -69.79, -11.11 321.73, 111.63 66.57, 27.33 in-out in 8.874 Saltbr-out 3.673 HRD-out -76.07, 95.41 -48.17, -63.17 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 177.03 APE8-dihe-in -61.6, 136.03 APE8-rot-in 305.18 APE67-dihe-in -74.33, -25.33 -56.72, -44.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.297 None None None EM 3.4 999.0 999.0 B 2527 1705 29 0 0 13 [[1875, 2134]] 1.0 8u8a TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8U8AC Q5S007 558 2526 2527.0 0LI:2601 Type2 Inactive DFGout 14.87 10.846 BBAminus -150.46, 144.31 -124.23, 97.69 -69.77, -11.06 321.78, 111.5 66.48, 27.35 in-out in 8.872 Saltbr-out 3.661 HRD-out -76.02, 95.48 -48.33, -63.13 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 177.01 APE8-dihe-in -61.57, 135.98 APE8-rot-in 305.14 APE67-dihe-in -74.37, -25.35 -56.73, -44.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.301 None None None EM 3.4 999.0 999.0 C 2527 1705 29 0 0 13 [[1875, 2134]] 1.0 8u8a TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 4C8BA O43353 8 316 540.0 0LI:1000 Type2 Inactive DFGout 12.729 8.584 None -142.99, -175.55 -154.35, 140.4 -129.56, 999.0 290.55, 114.67 999.0, 999.0 in-in in 8.243 Saltbr-in 2.817 HRD-in -79.84, -58.2 64.89, 19.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.9 APE8-dihe-out -84.71, -55.98 APE8-rot-none 999.0 APE67-dihe-in -64.98, -25.64 -68.13, -16.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.294 None None None XRAY 2.75 0.203 0.244 A 334 279 30 0 0 22 [[18, 292]] 1.0 4c8b TKL_RIPK2_HUMAN TKL 3.4e-73 252.4 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 4C8BB O43353 9 316 540.0 0LI:1000 Type2 Inactive DFGout 12.84 8.86 None -140.63, -176.63 -153.18, 138.54 -119.75, 999.0 285.35, 113.34 999.0, 999.0 in-in in 8.264 Saltbr-in 2.806 HRD-in -79.98, -59.74 66.42, 17.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -39.27 APE8-dihe-out -68.6, -38.75 APE8-rot-out 169.06 APE67-dihe-in -64.78, -24.38 -61.46, -15.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.445 None None None XRAY 2.75 0.203 0.244 B 334 281 27 0 0 22 [[18, 292]] 1.0 4c8b TKL_RIPK2_HUMAN TKL 3.4e-73 252.4 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TYR DDR1 DDR1_HUMAN 3ZOSB Q08345 601 913 913.0 0LI:61000 Type2 Inactive DFGout 13.646 9.63 BBAminus -143.84, 178.94 -153.3, 114.42 -82.71, -15.18 287.49, 108.73 52.14, -127.46 in-in in 7.96 Saltbr-in 2.883 HRD-in -60.43, -59.89 83.25, -8.8 in-out-in SNCioi out-in ActLoopNT-out 17.4 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.91, 133.24 APE9-dihe-in -130.81, 142.32 APE8-dihe-in -80.63, 68.61 APE8-rot-na 30.08 APE67-dihe-in -67.12, -16.99 -59.3, -31.33 APE12-dist-na 11.719 APE11-dist-na 12.939 APE10-dist-na 10.223 APE9-dist-in 7.924 None None None XRAY 1.92 0.208 0.234 B 315 301 12 0 0 0 [[610, 907]] 1.0 3zos TYR_DDR1_HUMAN TYR 1.5e-92 315.5 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 3ZOSA Q08345 602 913 913.0 0LI:61000,0LI:61004 Type2,Allosteric Inactive DFGout 13.684 9.765 BBAminus -140.01, 179.9 -153.22, 112.84 -85.26, -13.51 285.68, 107.96 48.92, -126.09 in-in in 7.998 Saltbr-in 2.881 HRD-in -61.25, -58.95 80.5, -7.41 in-out-in SNCioi out-in ActLoopNT-out 17.476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.17, 140.69 APE9-dihe-in -129.43, 143.43 APE8-dihe-in -82.4, 69.11 APE8-rot-na 29.15 APE67-dihe-in -67.51, -15.14 -58.33, -33.07 APE12-dist-na 11.707 APE11-dist-na 12.385 APE10-dist-na 10.171 APE9-dist-in 7.92 None None None XRAY 1.92 0.208 0.234 A 315 301 11 0 0 0 [[610, 907]] 1.0 3zos TYR_DDR1_HUMAN TYR 1.5e-92 315.5 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR FGFR1 FGFR1_HUMAN 4V04B P11362 458 765 822.0 0LI:1771 Type2 Inactive DFGout 13.974 9.873 BBAminus -127.4, -173.98 -164.99, 120.92 -104.35, 44.71 306.97, 107.67 29.41, -12.23 in-in in 7.692 Saltbr-in 3.015 HRD-in -72.1, -51.88 81.11, -15.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.55, 155.16 APE9-dihe-in -98.03, 109.95 APE8-dihe-out -52.12, -21.56 APE8-rot-na 329.22 APE67-dihe-in -70.06, -7.36 -58.08, -24.0 APE12-dist-na 19.514 APE11-dist-na 20.97 APE10-dist-na 19.298 APE9-dist-out 11.591 C488A,C584S None None XRAY 2.12 0.188 0.228 B 309 289 19 0 0 6 [[478, 756]] 1.0 4v04 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4V01A P11362 465 765 822.0 0LI:1776 Type2 Inactive DFGout 13.648 9.683 None -136.22, -176.63 -157.46, 111.62 -99.01, 999.0 301.26, 98.54 999.0, 999.0 in-in in 7.852 Saltbr-in 2.824 HRD-in -71.33, -57.3 83.26, -24.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.02, 147.14 APE9-dihe-in -94.17, 112.67 APE8-dihe-out -54.82, -21.48 APE8-rot-na 334.27 APE67-dihe-in -70.4, -11.17 -58.27, -24.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.727 C488A,C584S None None XRAY 2.33 0.191 0.238 A 309 273 28 0 0 8 [[478, 756]] 1.0 4v01 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4V01B P11362 461 763 822.0 0LI:1770 Type2 Inactive DFGout 13.476 9.083 None -140.66, -178.05 -156.06, 123.42 -117.89, 999.0 302.59, 94.37 999.0, 999.0 in-in in 7.916 Saltbr-in 2.807 HRD-in -63.92, -54.57 77.31, -15.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -101.11, 164.12 APE9-dihe-in -107.61, 109.54 APE8-dihe-out -56.39, -11.31 APE8-rot-na 332.13 APE67-dihe-in -66.82, -7.77 -66.39, -26.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.814 C488A,C584S None None XRAY 2.33 0.191 0.238 B 309 275 28 0 0 8 [[478, 756]] 1.0 4v01 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4V04A P11362 463 765 822.0 0LI:1772 Type2 Inactive DFGout 14.051 10.394 None -127.25, -179.24 -145.47, 116.11 -167.94, 35.9 26.55, 54.39 23.93, -5.2 in-in in 7.864 Saltbr-in 3.206 HRD-in -65.2, -58.04 83.28, -16.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.41, 155.12 APE9-dihe-in -98.09, 110.26 APE8-dihe-out -52.77, -21.99 APE8-rot-na 329.65 APE67-dihe-in -70.41, -8.08 -56.89, -24.83 APE12-dist-na 19.639 APE11-dist-na 21.02 APE10-dist-na 19.322 APE9-dist-out 11.7 C488A,C584S None None XRAY 2.12 0.188 0.228 A 309 293 10 0 0 6 [[478, 756]] 1.0 4v04 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR4 FGFR4_HUMAN 4UXQA P22455 452 750 802.0 0LI:1752 Type2 Inactive DFGout 13.289 9.688 BBAminus -132.52, -175.6 -154.98, 108.32 -101.68, -37.05 301.67, 99.59 -82.32, -172.58 in-in in 7.813 Saltbr-in 2.727 HRD-in -74.83, -56.93 88.13, -22.48 in-out-out SNCioo out-out ActLoopNT-out 15.96 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -78.09, 139.64 APE9-dihe-in -109.24, 95.28 APE8-dihe-out -52.11, -28.25 APE8-rot-na 327.58 APE67-dihe-in -73.35, -9.88 -60.02, -19.19 APE12-dist-na 12.227 APE11-dist-na 12.924 APE10-dist-na 10.113 APE9-dist-out 11.612 C477A None None XRAY 1.85 0.205 0.268 A 309 286 13 0 0 0 [[467, 745]] 1.0 4uxq TYR_FGFR4_HUMAN TYR 8.2e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 4TYJA P22455 447 753 802.0 0LI:60801 Type2 Inactive DFGout 13.629 9.602 BBAminus -136.8, -177.28 -149.4, 114.79 -98.18, 9.17 298.44, 103.78 79.91, -171.4 in-in in 7.82 Saltbr-in 2.757 HRD-in -71.95, -55.51 84.74, -19.01 in-out-out SNCioo out-out ActLoopNT-out 19.108 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.68 APE8-dihe-in -83.91, 64.17 APE8-rot-na 36.55 APE67-dihe-in -73.09, -8.81 -53.35, -41.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.819 None None None XRAY 2.45 0.217 0.247 A 311 275 32 0 0 15 [[467, 745]] 1.0 4tyj TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 4QRCA P22455 454 750 802.0 0LI:802 Type2 Inactive DFGout 13.848 9.448 None -128.93, 176.89 -168.87, 140.49 58.84, 41.6 314.29, 151.03 128.95, 161.76 in-in in 7.269 Saltbr-in 2.545 HRD-in -73.23, -52.1 79.8, -10.52 in-out-out SNCioo out-out ActLoopNT-out 8.662 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.02, 138.09 APE9-dihe-in -108.95, 92.74 APE8-dihe-out -61.85, -18.49 APE8-rot-na 333.49 APE67-dihe-in -72.31, -7.32 -59.05, -24.57 APE12-dist-na 19.537 APE11-dist-na 21.047 APE10-dist-na 16.873 APE9-dist-out 12.017 C477A,R664E None None XRAY 1.901 0.173 0.207 A 323 297 0 0 0 0 [[467, 745]] 1.0 4qrc TYR_FGFR4_HUMAN TYR 1.5e-100 341.7 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR KIT KIT_HUMAN 8S17A P10721 567 931 976.0 0LI:61001 Type2 Inactive DFGout 15.425 9.951 BBAminus -145.25, 179.39 -143.98, 106.64 -67.34, -40.16 274.67, 96.68 58.73, -115.03 in-in in 7.749 Saltbr-in 2.696 HRD-in -73.68, -54.05 81.88, -13.47 in-out-in SNCioi out-in ActLoopNT-out 16.311 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.0, 112.95 APE9-dihe-in -124.02, 150.83 APE8-dihe-in -80.03, 74.01 APE8-rot-na 32.18 APE67-dihe-in -67.91, -14.83 -61.86, -40.28 APE12-dist-na 16.635 APE11-dist-na 13.202 APE10-dist-na 11.515 APE9-dist-in 7.701 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.2 0.203 0.228 A 327 287 0 0 0 0 [[589, 926]] 1.0 8s17 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8S17B P10721 578 931 976.0 0LI:61001 Type2 Inactive DFGout 15.227 9.879 BBAminus -145.11, 172.96 -138.62, 103.76 -65.65, -38.27 276.93, 92.02 61.53, -118.4 in-in in 7.652 Saltbr-in 2.743 HRD-in -69.78, -55.3 82.77, -9.47 in-out-in SNCioi out-in ActLoopNT-out 16.408 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.26, 116.47 APE9-dihe-in -128.18, 149.58 APE8-dihe-in -80.46, 72.63 APE8-rot-na 32.73 APE67-dihe-in -67.64, -17.39 -58.96, -38.89 APE12-dist-na 16.505 APE11-dist-na 13.309 APE10-dist-na 11.718 APE9-dist-in 7.975 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.2 0.203 0.228 B 327 276 0 0 0 0 [[589, 926]] 1.0 8s17 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 4U0IA P10721 565 933 976.0 0LI:1001 Type2 Inactive DFGout 15.152 9.758 BBAminus -145.62, -174.19 -155.03, 115.98 -76.91, -26.31 285.47, 90.73 51.17, -116.44 in-in in 7.686 Saltbr-in 2.619 HRD-in -74.87, -53.81 79.28, -20.01 in-out-in SNCioi out-in ActLoopNT-out 16.446 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.86, 120.83 APE9-dihe-in -126.16, 149.12 APE8-dihe-in -78.54, 70.26 APE8-rot-na 32.2 APE67-dihe-in -61.59, -16.21 -59.65, -43.09 APE12-dist-na 17.193 APE11-dist-na 14.015 APE10-dist-na 12.164 APE9-dist-in 7.681 None None None XRAY 2.0 0.204 0.239 A 315 297 12 0 0 0 [[589, 926]] 1.0 4u0i TYR_KIT_HUMAN TYR 3.8e-102 347.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR ROR1 ROR1_HUMAN 6TU9A Q01973 460 749 937.0 0LI:801 Type1 Pseudo None 999.0 999.0 None -143.45, 175.76 -148.29, 81.04 -104.43, 119.64 999.0, 999.0 -53.65, -7.79 in-in in 8.227 Saltbr-in 2.725 HRD-in -69.35, -57.72 81.6, -11.35 in-out-in SNCioi out-in ActLoopNT-out 15.395 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.59, 129.49 APE9-dihe-in -125.15, 133.19 APE8-dihe-in -78.4, 68.8 APE8-rot-na 36.93 APE67-dihe-in -68.17, -18.18 -55.42, -35.07 APE12-dist-na 999.0 APE11-dist-na 15.69 APE10-dist-na 11.605 APE9-dist-in 6.992 None None None XRAY 1.94 0.21 0.241 A 306 268 22 0 0 4 [[473, 748]] 1.0 6tu9 TYR_ROR1_HUMAN TYR 1.2e-94 322.4 2 260 259 632 633 634 636 638 506 523 527 612 614 613 615 674 662 657 656 655 654 653 652 651 553 Inactive tyrosine-protein kinase transmembrane receptor ROR1
TYR ROR1 ROR1_HUMAN 6TU9B Q01973 465 750 937.0 0LI:801 Type1 Pseudo None 999.0 999.0 None -143.03, 176.7 -144.7, 81.77 -85.65, -31.03 999.0, 999.0 92.49, -44.82 in-in in 8.283 Saltbr-in 2.974 HRD-in -64.86, -61.91 82.91, -9.99 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.96, 129.63 APE9-dihe-in -119.15, 127.45 APE8-dihe-in -76.72, 68.52 APE8-rot-na 33.66 APE67-dihe-in -67.05, -20.69 -57.04, -32.64 APE12-dist-na 17.025 APE11-dist-na 15.144 APE10-dist-na 11.197 APE9-dist-in 6.97 None None None XRAY 1.94 0.21 0.241 B 306 261 25 0 0 2 [[473, 748]] 1.0 6tu9 TYR_ROR1_HUMAN TYR 1.2e-94 322.4 2 260 259 632 633 634 636 638 506 523 527 612 614 613 615 674 662 657 656 655 654 653 652 651 553 Inactive tyrosine-protein kinase transmembrane receptor ROR1
TYR SRC SRC_HUMAN 7OTEA P12931 261 536 536.0 0LI:601 Type2 Inactive DFGout 13.678 9.025 BBAminus -119.79, 176.26 -136.22, 145.66 -117.56, 59.41 289.7, 90.17 173.51, 999.0 in-in in 7.879 Saltbr-in 2.532 HRD-in -78.56, -49.16 85.49, -24.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 150.65 APE8-dihe-in -61.46, 92.79 APE8-rot-na 30.48 APE67-dihe-in -70.25, -17.48 -54.65, -43.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.618 None None None XRAY 2.49 0.179 0.252 A 293 259 17 0 0 17 [[270, 521]] 1.0 7ote TYR_SRC_HUMAN TYR 1.8e-94 321.9 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 7OTEB P12931 261 536 536.0 0LI:601 Type2 Inactive DFGout 14.508 9.181 BBAminus -149.51, 179.45 -147.71, 103.83 -80.1, -7.38 295.65, 135.68 68.38, 999.0 in-out in 8.912 Saltbr-out 4.135 HRD-in -81.29, -57.98 98.12, -42.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.79 APE8-dihe-in -102.78, 62.88 APE8-rot-na 39.14 APE67-dihe-in -65.77, -18.22 -41.35, -46.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.298 None None None XRAY 2.49 0.179 0.252 B 293 259 17 0 0 17 [[270, 521]] 1.0 7ote TYR_SRC_HUMAN TYR 1.8e-94 321.9 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src

Ligand: LI

Total number of chains: 33
Active chains: 1
Total number of genes: 14
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 19 57.6% 3IK3B
DFGout None 9 27.3% 4QRCA
DFGin BLAminus 3 9.1% 4DTKA
None None 2 6.1% 6TU9A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 7WF5A P00523 257 533 533.0 0LI:601 Type2 Inactive DFGout 13.293 8.853 BBAminus -138.86, 178.47 -148.72, 117.06 -103.55, 7.74 290.87, 100.32 61.55, 53.93 in-in in 7.671 Saltbr-in 2.617 HRD-in -81.35, -59.57 92.68, -15.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.23 APE8-dihe-in -80.1, 61.84 APE8-rot-na 34.61 APE67-dihe-in -62.67, -20.24 -53.79, -38.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.003 None None None XRAY 1.798 0.163 0.183 A 286 261 16 0 0 16 [[267, 518]] 1.0 7wf5 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 7WF5B P00523 254 533 533.0 0LI:601 Type2 Inactive DFGout 13.337 8.808 BBAminus -139.72, 178.97 -149.88, 114.3 -104.08, 8.92 292.96, 104.73 64.81, 53.74 in-in in 7.856 Saltbr-in 2.792 HRD-in -81.76, -58.24 93.94, -19.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.23 APE8-dihe-in -81.79, 58.44 APE8-rot-na 33.89 APE67-dihe-in -61.6, -25.83 -54.2, -35.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.562 None None None XRAY 1.798 0.163 0.183 B 286 265 15 0 0 15 [[267, 518]] 1.0 7wf5 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
CAMK PIM1 PIM1_HUMAN 4DTKA P11309 33 305 313.0 7LI:408 Type1 Active DFGin 6.142 14.661 BLAminus -128.39, 173.69 63.23, 87.87 -95.85, 17.29 285.67, 80.15 -64.1, -18.22 in-in in 8.861 Saltbr-in 2.588 HRD-na-A -66.25, -50.01 70.2, 5.45 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.52, 26.77 APE9-dihe-na -86.23, -154.0 APE8-dihe-in -89.22, 120.59 APE8-rot-in 306.1 APE67-dihe-in -65.85, -11.4 -53.32, -45.84 APE12-dist-in 9.701 APE11-dist-in 8.585 APE10-dist-in 5.474 APE9-dist-in 3.692 None None None XRAY 1.86 0.166 0.182 A 276 273 0 0 0 0 [[38, 290]] 1.0 4dtk Homo sapiens CAMK_PIM1_HUMAN CAMK 2.5e-65 226.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CMGC DYRK1A DYR1A_HUMAN 7O7KA Q13627 134 480 763.0 6ZV:803,LI:813 Type1,Allosteric Inactive DFGin 7.479 14.978 BLAminus -123.84, 172.32 71.95, 80.41 -97.61, 20.16 282.45, 81.55 -75.41, -18.82 in-in in 8.732 Saltbr-in 2.569 HRD-in -66.95, -44.76 74.49, -2.2 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.45, 171.41 APE9-dihe-na 76.66, 152.25 APE8-dihe-in -71.23, 142.04 APE8-rot-out 204.57 APE67-dihe-in -61.2, -25.53 -57.62, -46.09 APE12-dist-in 13.826 APE11-dist-in 12.396 APE10-dist-in 7.934 APE9-dist-in 3.209 None PTR321 PTR321 XRAY 1.82 0.179 0.205 A 361 345 2 0 0 0 [[159, 479]] 1.0 7o7k Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7O7KB Q13627 133 480 763.0 6ZV:504,LI:516 Type1,Allosteric Inactive DFGin 7.549 15.002 BLAminus -123.44, 173.38 69.65, 80.66 -97.78, 19.84 280.19, 88.12 -76.56, -16.84 in-in in 8.721 Saltbr-in 2.45 HRD-in -66.14, -44.61 73.06, -2.94 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -122.41, 168.28 APE9-dihe-na 77.46, 151.66 APE8-dihe-in -70.04, 138.71 APE8-rot-out 178.34 APE67-dihe-in -60.28, -25.12 -56.13, -47.11 APE12-dist-in 13.885 APE11-dist-in 12.364 APE10-dist-out 8.042 APE9-dist-in 3.108 None PTR321 PTR321 XRAY 1.82 0.179 0.205 B 361 345 3 0 0 0 [[159, 479]] 1.0 7o7k Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
STE MAP3K2 M3K2_HUMAN 9P6AA Q9Y2U5 351 617 619.0 0LI:701 Type2 Inactive DFGout 14.143 9.891 BBAminus -146.02, -172.59 -157.95, 116.33 -87.88, -36.33 294.81, 102.45 -88.54, 36.79 in-in in 8.458 Saltbr-in 2.594 HRD-in -76.59, -52.31 80.62, -19.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.17, -51.62 APE9-dihe-na -96.01, 162.48 APE8-dihe-in -81.48, 131.06 APE8-rot-out 69.69 APE67-dihe-in -67.88, -22.22 -92.28, 3.15 APE12-dist-out 20.682 APE11-dist-out 19.144 APE10-dist-out 14.309 APE9-dist-out 10.456 None None None XRAY 2.4 0.228 0.246 A 299 253 14 0 0 14 [[356, 616]] 1.0 9p6a Homo sapiens STE_MAP3K2_HUMAN STE 1.9e-81 279.1 1 257 257 500 501 502 504 506 385 406 410 480 482 481 483 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2
STE MAP3K2 M3K2_HUMAN 9P6AB Q9Y2U5 347 618 619.0 0LI:701 Type2 Inactive DFGout 13.802 9.756 None -145.97, -173.02 -157.2, 114.58 -90.61, 158.12 297.06, 102.49 67.12, -99.7 in-in in 8.631 Saltbr-in 2.727 HRD-in -74.0, -48.74 85.04, -22.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -168.99 APE9-dihe-na -96.92, -27.66 APE8-dihe-in -82.09, 127.1 APE8-rot-out 70.19 APE67-dihe-in -70.58, -23.59 -96.42, -0.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.637 APE9-dist-out 10.787 None None None XRAY 2.4 0.228 0.246 B 299 247 25 0 0 16 [[356, 616]] 1.0 9p6a Homo sapiens STE_MAP3K2_HUMAN STE 1.9e-81 279.1 1 257 257 500 501 502 504 506 385 406 410 480 482 481 483 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2
TKL BRAF BRAF_HUMAN 6P3DA P15056 448 721 766.0 0LI:61001 Type2 Inactive DFGout 12.35 10.905 BBAminus -138.54, -166.92 -135.05, 80.45 -80.66, -37.84 293.17, 97.28 81.0, 10.25 in-in in 8.665 Saltbr-in 2.997 HRD-in -65.6, -55.77 77.59, -19.55 in-out-out SNCioo out-out ActLoopNT-out 19.945 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -19.82 APE9-dihe-na 76.62, -63.3 APE8-dihe-out -51.89, -23.77 APE8-rot-out 78.9 APE67-dihe-in -55.73, -23.59 -56.01, -24.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.7 APE9-dist-out 11.871 None None None XRAY 2.11 0.188 0.245 A 297 261 13 0 0 13 [[457, 716]] 1.0 6p3d Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 6EG9A Q9NWZ3 164 459 460.0 0LI:501 Type2 Inactive DFGout 14.071 10.716 None -127.45, 167.3 -138.69, 101.47 -85.85, 140.23 309.7, 100.41 -43.19, 999.0 in-out in 9.027 Saltbr-out 6.646 HRD-in -71.51, -48.43 70.86, -5.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 6.91 APE9-dihe-na 158.59, -165.8 APE8-dihe-in -114.99, 116.82 APE8-rot-in 299.55 APE67-dihe-in -67.65, -20.43 -63.19, -29.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.972 None None None XRAY 2.414 0.224 0.249 A 312 276 20 0 0 17 [[183, 456]] 1.0 6eg9 Homo sapiens TKL_IRAK4_HUMAN TKL 4.6e-84 288.0 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EG9B Q9NWZ3 165 459 460.0 0LI:501 Type2 Inactive DFGout 14.244 9.395 None -135.81, 174.82 -152.29, 126.78 -163.75, 999.0 33.58, 60.29 999.0, 999.0 in-in in 8.979 Saltbr-in 3.09 HRD-in -69.81, -51.27 77.39, -7.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 146.5 APE9-dihe-na 95.5, 175.38 APE8-dihe-in -117.78, 118.94 APE8-rot-in 307.93 APE67-dihe-in -67.02, -18.64 -61.22, -30.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.63 None None None XRAY 2.414 0.224 0.249 B 312 274 21 0 0 18 [[183, 456]] 1.0 6eg9 Homo sapiens TKL_IRAK4_HUMAN TKL 4.6e-84 288.0 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL LRRK2 LRRK2_HUMAN 8U8AB Q5S007 558 2526 2527.0 0LI:2601 Type2 Inactive DFGout 14.859 10.845 BBAminus -150.37, 144.32 -124.19, 97.68 -69.79, -11.11 321.73, 111.63 66.57, 27.33 in-out in 8.874 Saltbr-out 3.673 HRD-out -76.07, 95.41 -48.17, -63.17 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 177.03 APE8-dihe-in -61.6, 136.03 APE8-rot-in 305.18 APE67-dihe-in -74.33, -25.33 -56.72, -44.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.297 None None None EM 3.4 999.0 999.0 B 2527 1705 29 0 0 13 [[1875, 2134]] 1.0 8u8a Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8U8AC Q5S007 558 2526 2527.0 0LI:2601 Type2 Inactive DFGout 14.87 10.846 BBAminus -150.46, 144.31 -124.23, 97.69 -69.77, -11.06 321.78, 111.5 66.48, 27.35 in-out in 8.872 Saltbr-out 3.661 HRD-out -76.02, 95.48 -48.33, -63.13 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 177.01 APE8-dihe-in -61.57, 135.98 APE8-rot-in 305.14 APE67-dihe-in -74.37, -25.35 -56.73, -44.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.301 None None None EM 3.4 999.0 999.0 C 2527 1705 29 0 0 13 [[1875, 2134]] 1.0 8u8a Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 4C8BA O43353 8 316 540.0 0LI:1000 Type2 Inactive DFGout 12.729 8.584 None -142.99, -175.55 -154.35, 140.4 -129.56, 999.0 290.55, 114.67 999.0, 999.0 in-in in 8.243 Saltbr-in 2.817 HRD-in -79.84, -58.2 64.89, 19.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.9 APE8-dihe-out -84.71, -55.98 APE8-rot-none 999.0 APE67-dihe-in -64.98, -25.64 -68.13, -16.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.294 None None None XRAY 2.75 0.203 0.244 A 334 279 30 0 0 22 [[18, 292]] 1.0 4c8b Homo sapiens TKL_RIPK2_HUMAN TKL 3.4e-73 252.4 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 4C8BB O43353 9 316 540.0 0LI:1000 Type2 Inactive DFGout 12.84 8.86 None -140.63, -176.63 -153.18, 138.54 -119.75, 999.0 285.35, 113.34 999.0, 999.0 in-in in 8.264 Saltbr-in 2.806 HRD-in -79.98, -59.74 66.42, 17.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -39.27 APE8-dihe-out -68.6, -38.75 APE8-rot-out 169.06 APE67-dihe-in -64.78, -24.38 -61.46, -15.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.445 None None None XRAY 2.75 0.203 0.244 B 334 281 27 0 0 22 [[18, 292]] 1.0 4c8b Homo sapiens TKL_RIPK2_HUMAN TKL 3.4e-73 252.4 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TYR DDR1 DDR1_HUMAN 3ZOSB Q08345 601 913 913.0 0LI:61000 Type2 Inactive DFGout 13.646 9.63 BBAminus -143.84, 178.94 -153.3, 114.42 -82.71, -15.18 287.49, 108.73 52.14, -127.46 in-in in 7.96 Saltbr-in 2.883 HRD-in -60.43, -59.89 83.25, -8.8 in-out-in SNCioi out-in ActLoopNT-out 17.4 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.91, 133.24 APE9-dihe-in -130.81, 142.32 APE8-dihe-in -80.63, 68.61 APE8-rot-na 30.08 APE67-dihe-in -67.12, -16.99 -59.3, -31.33 APE12-dist-na 11.719 APE11-dist-na 12.939 APE10-dist-na 10.223 APE9-dist-in 7.924 None None None XRAY 1.92 0.208 0.234 B 315 301 12 0 0 0 [[610, 907]] 1.0 3zos Homo sapiens TYR_DDR1_HUMAN TYR 1.5e-92 315.5 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 3ZOSA Q08345 602 913 913.0 0LI:61000,0LI:61004 Type2,Allosteric Inactive DFGout 13.684 9.765 BBAminus -140.01, 179.9 -153.22, 112.84 -85.26, -13.51 285.68, 107.96 48.92, -126.09 in-in in 7.998 Saltbr-in 2.881 HRD-in -61.25, -58.95 80.5, -7.41 in-out-in SNCioi out-in ActLoopNT-out 17.476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.17, 140.69 APE9-dihe-in -129.43, 143.43 APE8-dihe-in -82.4, 69.11 APE8-rot-na 29.15 APE67-dihe-in -67.51, -15.14 -58.33, -33.07 APE12-dist-na 11.707 APE11-dist-na 12.385 APE10-dist-na 10.171 APE9-dist-in 7.92 None None None XRAY 1.92 0.208 0.234 A 315 301 11 0 0 0 [[610, 907]] 1.0 3zos Homo sapiens TYR_DDR1_HUMAN TYR 1.5e-92 315.5 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR FGFR1 FGFR1_HUMAN 4V04B P11362 458 765 822.0 0LI:1771 Type2 Inactive DFGout 13.974 9.873 BBAminus -127.4, -173.98 -164.99, 120.92 -104.35, 44.71 306.97, 107.67 29.41, -12.23 in-in in 7.692 Saltbr-in 3.015 HRD-in -72.1, -51.88 81.11, -15.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.55, 155.16 APE9-dihe-in -98.03, 109.95 APE8-dihe-out -52.12, -21.56 APE8-rot-na 329.22 APE67-dihe-in -70.06, -7.36 -58.08, -24.0 APE12-dist-na 19.514 APE11-dist-na 20.97 APE10-dist-na 19.298 APE9-dist-out 11.591 C488A,C584S None None XRAY 2.12 0.188 0.228 B 309 289 19 0 0 6 [[478, 756]] 1.0 4v04 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4V01A P11362 465 765 822.0 0LI:1776 Type2 Inactive DFGout 13.648 9.683 None -136.22, -176.63 -157.46, 111.62 -99.01, 999.0 301.26, 98.54 999.0, 999.0 in-in in 7.852 Saltbr-in 2.824 HRD-in -71.33, -57.3 83.26, -24.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.02, 147.14 APE9-dihe-in -94.17, 112.67 APE8-dihe-out -54.82, -21.48 APE8-rot-na 334.27 APE67-dihe-in -70.4, -11.17 -58.27, -24.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.727 C488A,C584S None None XRAY 2.33 0.191 0.238 A 309 273 28 0 0 8 [[478, 756]] 1.0 4v01 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4V01B P11362 461 763 822.0 0LI:1770 Type2 Inactive DFGout 13.476 9.083 None -140.66, -178.05 -156.06, 123.42 -117.89, 999.0 302.59, 94.37 999.0, 999.0 in-in in 7.916 Saltbr-in 2.807 HRD-in -63.92, -54.57 77.31, -15.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -101.11, 164.12 APE9-dihe-in -107.61, 109.54 APE8-dihe-out -56.39, -11.31 APE8-rot-na 332.13 APE67-dihe-in -66.82, -7.77 -66.39, -26.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.814 C488A,C584S None None XRAY 2.33 0.191 0.238 B 309 275 28 0 0 8 [[478, 756]] 1.0 4v01 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4V04A P11362 463 765 822.0 0LI:1772 Type2 Inactive DFGout 14.051 10.394 None -127.25, -179.24 -145.47, 116.11 -167.94, 35.9 26.55, 54.39 23.93, -5.2 in-in in 7.864 Saltbr-in 3.206 HRD-in -65.2, -58.04 83.28, -16.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.41, 155.12 APE9-dihe-in -98.09, 110.26 APE8-dihe-out -52.77, -21.99 APE8-rot-na 329.65 APE67-dihe-in -70.41, -8.08 -56.89, -24.83 APE12-dist-na 19.639 APE11-dist-na 21.02 APE10-dist-na 19.322 APE9-dist-out 11.7 C488A,C584S None None XRAY 2.12 0.188 0.228 A 309 293 10 0 0 6 [[478, 756]] 1.0 4v04 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR4 FGFR4_HUMAN 4UXQA P22455 452 750 802.0 0LI:1752 Type2 Inactive DFGout 13.289 9.688 BBAminus -132.52, -175.6 -154.98, 108.32 -101.68, -37.05 301.67, 99.59 -82.32, -172.58 in-in in 7.813 Saltbr-in 2.727 HRD-in -74.83, -56.93 88.13, -22.48 in-out-out SNCioo out-out ActLoopNT-out 15.96 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -78.09, 139.64 APE9-dihe-in -109.24, 95.28 APE8-dihe-out -52.11, -28.25 APE8-rot-na 327.58 APE67-dihe-in -73.35, -9.88 -60.02, -19.19 APE12-dist-na 12.227 APE11-dist-na 12.924 APE10-dist-na 10.113 APE9-dist-out 11.612 C477A None None XRAY 1.85 0.205 0.268 A 309 286 13 0 0 0 [[467, 745]] 1.0 4uxq Homo sapiens TYR_FGFR4_HUMAN TYR 8.2e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 4TYJA P22455 447 753 802.0 0LI:60801 Type2 Inactive DFGout 13.629 9.602 BBAminus -136.8, -177.28 -149.4, 114.79 -98.18, 9.17 298.44, 103.78 79.91, -171.4 in-in in 7.82 Saltbr-in 2.757 HRD-in -71.95, -55.51 84.74, -19.01 in-out-out SNCioo out-out ActLoopNT-out 19.108 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.68 APE8-dihe-in -83.91, 64.17 APE8-rot-na 36.55 APE67-dihe-in -73.09, -8.81 -53.35, -41.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.819 None None None XRAY 2.45 0.217 0.247 A 311 275 32 0 0 15 [[467, 745]] 1.0 4tyj Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 4QRCA P22455 454 750 802.0 0LI:802 Type2 Inactive DFGout 13.848 9.448 None -128.93, 176.89 -168.87, 140.49 58.84, 41.6 314.29, 151.03 128.95, 161.76 in-in in 7.269 Saltbr-in 2.545 HRD-in -73.23, -52.1 79.8, -10.52 in-out-out SNCioo out-out ActLoopNT-out 8.662 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.02, 138.09 APE9-dihe-in -108.95, 92.74 APE8-dihe-out -61.85, -18.49 APE8-rot-na 333.49 APE67-dihe-in -72.31, -7.32 -59.05, -24.57 APE12-dist-na 19.537 APE11-dist-na 21.047 APE10-dist-na 16.873 APE9-dist-out 12.017 C477A,R664E None None XRAY 1.901 0.173 0.207 A 323 297 0 0 0 0 [[467, 745]] 1.0 4qrc Homo sapiens TYR_FGFR4_HUMAN TYR 1.5e-100 341.7 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR KIT KIT_HUMAN 8S17A P10721 567 931 976.0 0LI:61001 Type2 Inactive DFGout 15.425 9.951 BBAminus -145.25, 179.39 -143.98, 106.64 -67.34, -40.16 274.67, 96.68 58.73, -115.03 in-in in 7.749 Saltbr-in 2.696 HRD-in -73.68, -54.05 81.88, -13.47 in-out-in SNCioi out-in ActLoopNT-out 16.311 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.0, 112.95 APE9-dihe-in -124.02, 150.83 APE8-dihe-in -80.03, 74.01 APE8-rot-na 32.18 APE67-dihe-in -67.91, -14.83 -61.86, -40.28 APE12-dist-na 16.635 APE11-dist-na 13.202 APE10-dist-na 11.515 APE9-dist-in 7.701 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.2 0.203 0.228 A 327 287 0 0 0 0 [[589, 926]] 1.0 8s17 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8S17B P10721 578 931 976.0 0LI:61001 Type2 Inactive DFGout 15.227 9.879 BBAminus -145.11, 172.96 -138.62, 103.76 -65.65, -38.27 276.93, 92.02 61.53, -118.4 in-in in 7.652 Saltbr-in 2.743 HRD-in -69.78, -55.3 82.77, -9.47 in-out-in SNCioi out-in ActLoopNT-out 16.408 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.26, 116.47 APE9-dihe-in -128.18, 149.58 APE8-dihe-in -80.46, 72.63 APE8-rot-na 32.73 APE67-dihe-in -67.64, -17.39 -58.96, -38.89 APE12-dist-na 16.505 APE11-dist-na 13.309 APE10-dist-na 11.718 APE9-dist-in 7.975 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.2 0.203 0.228 B 327 276 0 0 0 0 [[589, 926]] 1.0 8s17 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 4U0IA P10721 565 933 976.0 0LI:1001 Type2 Inactive DFGout 15.152 9.758 BBAminus -145.62, -174.19 -155.03, 115.98 -76.91, -26.31 285.47, 90.73 51.17, -116.44 in-in in 7.686 Saltbr-in 2.619 HRD-in -74.87, -53.81 79.28, -20.01 in-out-in SNCioi out-in ActLoopNT-out 16.446 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.86, 120.83 APE9-dihe-in -126.16, 149.12 APE8-dihe-in -78.54, 70.26 APE8-rot-na 32.2 APE67-dihe-in -61.59, -16.21 -59.65, -43.09 APE12-dist-na 17.193 APE11-dist-na 14.015 APE10-dist-na 12.164 APE9-dist-in 7.681 None None None XRAY 2.0 0.204 0.239 A 315 297 12 0 0 0 [[589, 926]] 1.0 4u0i Homo sapiens TYR_KIT_HUMAN TYR 3.8e-102 347.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR ROR1 ROR1_HUMAN 6TU9A Q01973 460 749 937.0 0LI:801 Type1 Pseudo None 999.0 999.0 None -143.45, 175.76 -148.29, 81.04 -104.43, 119.64 999.0, 999.0 -53.65, -7.79 in-in in 8.227 Saltbr-in 2.725 HRD-in -69.35, -57.72 81.6, -11.35 in-out-in SNCioi out-in ActLoopNT-out 15.395 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.59, 129.49 APE9-dihe-in -125.15, 133.19 APE8-dihe-in -78.4, 68.8 APE8-rot-na 36.93 APE67-dihe-in -68.17, -18.18 -55.42, -35.07 APE12-dist-na 999.0 APE11-dist-na 15.69 APE10-dist-na 11.605 APE9-dist-in 6.992 None None None XRAY 1.94 0.21 0.241 A 306 268 22 0 0 4 [[473, 748]] 1.0 6tu9 Homo sapiens TYR_ROR1_HUMAN TYR 1.2e-94 322.4 2 260 259 632 633 634 636 638 506 523 527 612 614 613 615 674 662 657 656 655 654 653 652 651 553 Inactive tyrosine-protein kinase transmembrane receptor ROR1
TYR ROR1 ROR1_HUMAN 6TU9B Q01973 465 750 937.0 0LI:801 Type1 Pseudo None 999.0 999.0 None -143.03, 176.7 -144.7, 81.77 -85.65, -31.03 999.0, 999.0 92.49, -44.82 in-in in 8.283 Saltbr-in 2.974 HRD-in -64.86, -61.91 82.91, -9.99 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.96, 129.63 APE9-dihe-in -119.15, 127.45 APE8-dihe-in -76.72, 68.52 APE8-rot-na 33.66 APE67-dihe-in -67.05, -20.69 -57.04, -32.64 APE12-dist-na 17.025 APE11-dist-na 15.144 APE10-dist-na 11.197 APE9-dist-in 6.97 None None None XRAY 1.94 0.21 0.241 B 306 261 25 0 0 2 [[473, 748]] 1.0 6tu9 Homo sapiens TYR_ROR1_HUMAN TYR 1.2e-94 322.4 2 260 259 632 633 634 636 638 506 523 527 612 614 613 615 674 662 657 656 655 654 653 652 651 553 Inactive tyrosine-protein kinase transmembrane receptor ROR1
TYR SRC SRC_HUMAN 7OTEA P12931 261 536 536.0 0LI:601 Type2 Inactive DFGout 13.678 9.025 BBAminus -119.79, 176.26 -136.22, 145.66 -117.56, 59.41 289.7, 90.17 173.51, 999.0 in-in in 7.879 Saltbr-in 2.532 HRD-in -78.56, -49.16 85.49, -24.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 150.65 APE8-dihe-in -61.46, 92.79 APE8-rot-na 30.48 APE67-dihe-in -70.25, -17.48 -54.65, -43.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.618 None None None XRAY 2.49 0.179 0.252 A 293 259 17 0 0 17 [[270, 521]] 1.0 7ote Homo sapiens TYR_SRC_HUMAN TYR 1.8e-94 321.9 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 7OTEB P12931 261 536 536.0 0LI:601 Type2 Inactive DFGout 14.508 9.181 BBAminus -149.51, 179.45 -147.71, 103.83 -80.1, -7.38 295.65, 135.68 68.38, 999.0 in-out in 8.912 Saltbr-out 4.135 HRD-in -81.29, -57.98 98.12, -42.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.79 APE8-dihe-in -102.78, 62.88 APE8-rot-na 39.14 APE67-dihe-in -65.77, -18.22 -41.35, -46.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.298 None None None XRAY 2.49 0.179 0.252 B 293 259 17 0 0 17 [[270, 521]] 1.0 7ote Homo sapiens TYR_SRC_HUMAN TYR 1.8e-94 321.9 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR ABL1 ABL1_MOUSE 3IK3A P00520 229 513 1123.0 0LI:60001 Type2 Inactive DFGout 13.504 9.438 BBAminus -139.29, -179.88 -153.49, 108.65 -85.72, -9.94 290.6, 95.91 72.02, 48.56 in-in in 7.934 Saltbr-in 2.538 HRD-in -70.15, -60.9 90.87, -12.1 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.42, 120.77 APE9-dihe-in -114.74, 139.96 APE8-dihe-in -82.31, 89.85 APE8-rot-na 32.91 APE67-dihe-in -77.22, -7.68 -48.36, -44.8 APE12-dist-na 16.01 APE11-dist-na 11.84 APE10-dist-na 8.456 APE9-dist-in 7.993 T315I None None XRAY 1.9 0.216 0.258 A 288 279 6 0 0 6 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3IK3B P00520 229 513 1123.0 0LI:60002 Type2 Inactive DFGout 13.498 9.17 BBAminus -129.46, 178.53 -148.47, 114.27 -91.94, -7.12 286.37, 101.01 64.82, 50.27 in-in in 7.992 Saltbr-in 2.655 HRD-in -76.51, -54.44 85.69, -10.99 in-out-in SNCioi out-in ActLoopNT-out 15.703 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.88, 123.97 APE9-dihe-in -117.43, 141.07 APE8-dihe-in -76.99, 85.79 APE8-rot-na 29.46 APE67-dihe-in -85.08, -5.45 -41.61, -41.71 APE12-dist-na 15.826 APE11-dist-na 11.596 APE10-dist-na 8.603 APE9-dist-in 7.851 T315I None None XRAY 1.9 0.216 0.258 B 288 285 0 0 0 0 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3OXZA P00520 229 511 1123.0 0LI:60001 Type2 Inactive DFGout 13.316 8.94 BBAminus -130.11, -171.24 -154.37, 127.79 -115.42, 5.71 286.77, 98.95 48.45, 62.42 in-in in 8.004 Saltbr-in 3.005 HRD-in -71.2, -52.05 81.82, -16.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -90.47, 133.09 APE9-dihe-in -119.78, 140.42 APE8-dihe-in -76.32, 77.74 APE8-rot-na 32.13 APE67-dihe-in -76.96, -8.32 -43.1, -46.11 APE12-dist-na 15.377 APE11-dist-na 10.76 APE10-dist-na 8.339 APE9-dist-out 8.088 None None None XRAY 2.2 0.218 0.261 A 284 267 16 0 0 10 [[242, 495]] 1.0 3oxz Mus musculus TYR_ABL1_MOUSE TYR 2.6e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1

Ligand: LI

Total number of chains: 5
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 5 100.0% 3IK3B
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 7WF5A P00523 257 533 533.0 0LI:601 Type2 Inactive DFGout 13.293 8.853 BBAminus -138.86, 178.47 -148.72, 117.06 -103.55, 7.74 290.87, 100.32 61.55, 53.93 in-in in 7.671 Saltbr-in 2.617 HRD-in -81.35, -59.57 92.68, -15.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.23 APE8-dihe-in -80.1, 61.84 APE8-rot-na 34.61 APE67-dihe-in -62.67, -20.24 -53.79, -38.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.003 None None None XRAY 1.798 0.163 0.183 A 286 261 16 0 0 16 [[267, 518]] 1.0 7wf5 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 7WF5B P00523 254 533 533.0 0LI:601 Type2 Inactive DFGout 13.337 8.808 BBAminus -139.72, 178.97 -149.88, 114.3 -104.08, 8.92 292.96, 104.73 64.81, 53.74 in-in in 7.856 Saltbr-in 2.792 HRD-in -81.76, -58.24 93.94, -19.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.23 APE8-dihe-in -81.79, 58.44 APE8-rot-na 33.89 APE67-dihe-in -61.6, -25.83 -54.2, -35.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.562 None None None XRAY 1.798 0.163 0.183 B 286 265 15 0 0 15 [[267, 518]] 1.0 7wf5 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR ABL1 ABL1_MOUSE 3IK3A P00520 229 513 1123.0 0LI:60001 Type2 Inactive DFGout 13.504 9.438 BBAminus -139.29, -179.88 -153.49, 108.65 -85.72, -9.94 290.6, 95.91 72.02, 48.56 in-in in 7.934 Saltbr-in 2.538 HRD-in -70.15, -60.9 90.87, -12.1 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.42, 120.77 APE9-dihe-in -114.74, 139.96 APE8-dihe-in -82.31, 89.85 APE8-rot-na 32.91 APE67-dihe-in -77.22, -7.68 -48.36, -44.8 APE12-dist-na 16.01 APE11-dist-na 11.84 APE10-dist-na 8.456 APE9-dist-in 7.993 T315I None None XRAY 1.9 0.216 0.258 A 288 279 6 0 0 6 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3IK3B P00520 229 513 1123.0 0LI:60002 Type2 Inactive DFGout 13.498 9.17 BBAminus -129.46, 178.53 -148.47, 114.27 -91.94, -7.12 286.37, 101.01 64.82, 50.27 in-in in 7.992 Saltbr-in 2.655 HRD-in -76.51, -54.44 85.69, -10.99 in-out-in SNCioi out-in ActLoopNT-out 15.703 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.88, 123.97 APE9-dihe-in -117.43, 141.07 APE8-dihe-in -76.99, 85.79 APE8-rot-na 29.46 APE67-dihe-in -85.08, -5.45 -41.61, -41.71 APE12-dist-na 15.826 APE11-dist-na 11.596 APE10-dist-na 8.603 APE9-dist-in 7.851 T315I None None XRAY 1.9 0.216 0.258 B 288 285 0 0 0 0 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3OXZA P00520 229 511 1123.0 0LI:60001 Type2 Inactive DFGout 13.316 8.94 BBAminus -130.11, -171.24 -154.37, 127.79 -115.42, 5.71 286.77, 98.95 48.45, 62.42 in-in in 8.004 Saltbr-in 3.005 HRD-in -71.2, -52.05 81.82, -16.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -90.47, 133.09 APE9-dihe-in -119.78, 140.42 APE8-dihe-in -76.32, 77.74 APE8-rot-na 32.13 APE67-dihe-in -76.96, -8.32 -43.1, -46.11 APE12-dist-na 15.377 APE11-dist-na 10.76 APE10-dist-na 8.339 APE9-dist-out 8.088 None None None XRAY 2.2 0.218 0.261 A 284 267 16 0 0 10 [[242, 495]] 1.0 3oxz Mus musculus TYR_ABL1_MOUSE TYR 2.6e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1