Ligand: LI

Total number of chains: 30
Active chains: 2
Total number of genes: 15
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 14 46.7% 8S17A
DFGout None 9 30.0% 4QRCA
DFGin BLAminus 4 13.3% 4DTKA
None None 2 6.7% 6TU9A
DFGin BLBtrans 1 3.3% 9QVZA
All chains
Pymol session (all) Pymol script (all)
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK AURKA AURKA_HUMAN 9QVZA O14965 124 390 403.0 ADP:501,LI:506 ATPlike,Allosteric Inactive DFGin 6.104 17.565 BLBtrans DFGAsp-rot-out -120.9348, -175.2925 52.6829, 52.4808 290.9234, 60.3612 -81.4885, 60.9708 219.9237, 106.9888 -92.5523, 91.9137 out-out out 10.467 Saltbr-out 4.251 HRD-in -65.2039, -55.0867 57.7579, 30.8856 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -164.2282, 150.125 APE9-dihe-na 128.8633, 144.1058 APE8-dihe-in -91.8178, 126.6478 APE8-rot-in 308.2626 APE67-dihe-in -58.8199, -19.121 -57.7541, -46.5905 APE12-dist-in 13.234 APE11-dist-in 13.13 APE10-dist-out 8.652 APE9-dist-in 5.069 C290A,C393A None None XRAY 2.39 0.294 0.336 A 285 254 13 0 0 10 [[133, 383]] 1.0 9qvz CAMK_AURKA_HUMAN CAMK 9.7e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK PIM1 PIM1_HUMAN 4DTKA P11309 33 305 313.0 7LI:408 Type1 Active DFGin 6.142 14.661 BLAminus DFGAsp-rot-in -128.39, 173.69 63.23, 87.87 199.22, -2.97 -95.85, 17.29 285.67, 80.15 -64.1, -18.22 in-in in 8.861 Saltbr-in 2.588 HRD-na-A -66.25, -50.01 70.2, 5.45 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.52, 26.77 APE9-dihe-na -86.23, -154.0 APE8-dihe-in -89.22, 120.59 APE8-rot-in 306.1 APE67-dihe-in -65.85, -11.4 -53.32, -45.84 APE12-dist-in 9.701 APE11-dist-in 8.585 APE10-dist-in 5.474 APE9-dist-in 3.692 None None None XRAY 1.86 0.166 0.182 A 276 273 0 0 0 0 [[38, 290]] 1.0 4dtk CAMK_PIM1_HUMAN CAMK 2.6e-65 226.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CMGC DYRK1A DYR1A_HUMAN 7O7KA Q13627 134 480 763.0 6ZV:803,LI:813 Type1,Allosteric Inactive DFGin 7.479 14.978 BLAminus DFGAsp-rot-in -123.84, 172.32 71.95, 80.41 186.45, 22.97 -97.61, 20.16 282.45, 81.55 -75.41, -18.82 in-in in 8.732 Saltbr-in 2.569 HRD-in -66.95, -44.76 74.49, -2.2 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.45, 171.41 APE9-dihe-na 76.66, 152.25 APE8-dihe-in -71.23, 142.04 APE8-rot-out 204.57 APE67-dihe-in -61.2, -25.53 -57.62, -46.09 APE12-dist-in 13.826 APE11-dist-in 12.396 APE10-dist-in 7.934 APE9-dist-in 3.209 None PTR321 PTR321 XRAY 1.82 0.179 0.205 A 361 345 2 0 0 0 [[159, 479]] 1.0 7o7k CMGC_DYRK1A_HUMAN CMGC 8.7e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7O7KB Q13627 133 480 763.0 6ZV:504,LI:516 Type1,Allosteric Inactive DFGin 7.549 15.002 BLAminus DFGAsp-rot-in -123.44, 173.38 69.65, 80.66 189.78, 20.14 -97.78, 19.84 280.19, 88.12 -76.56, -16.84 in-in in 8.721 Saltbr-in 2.45 HRD-in -66.14, -44.61 73.06, -2.94 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -122.41, 168.28 APE9-dihe-na 77.46, 151.66 APE8-dihe-in -70.04, 138.71 APE8-rot-out 178.34 APE67-dihe-in -60.28, -25.12 -56.13, -47.11 APE12-dist-in 13.885 APE11-dist-in 12.364 APE10-dist-out 8.042 APE9-dist-in 3.108 None PTR321 PTR321 XRAY 1.82 0.179 0.205 B 361 345 3 0 0 0 [[159, 479]] 1.0 7o7k CMGC_DYRK1A_HUMAN CMGC 8.7e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
STE MAP3K2 M3K2_HUMAN 9P6AA Q9Y2U5 351 617 619.0 0LI:701 Type2 Inactive DFGout 14.143 9.891 BBAminus DFGAsp-rot-in -146.02, -172.59 -157.95, 116.33 191.45, 14.99 -87.88, -36.33 294.81, 102.45 -88.54, 36.79 in-in in 8.458 Saltbr-in 2.594 HRD-in -76.59, -52.31 80.62, -19.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.17, -51.62 APE9-dihe-na -96.01, 162.48 APE8-dihe-in -81.48, 131.06 APE8-rot-out 69.69 APE67-dihe-in -67.88, -22.22 -92.28, 3.15 APE12-dist-out 20.682 APE11-dist-out 19.144 APE10-dist-out 14.309 APE9-dist-out 10.456 None None None XRAY 2.4 0.228 0.246 A 299 253 14 0 0 14 [[356, 616]] 1.0 9p6a STE_MAP3K2_HUMAN STE 1.9e-81 279.1 1 257 257 500 501 502 504 506 385 406 410 480 482 481 483 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2
STE MAP3K2 M3K2_HUMAN 9P6AB Q9Y2U5 347 618 619.0 0LI:701 Type2 Inactive DFGout 13.802 9.756 None DFGAsp-rot-in -145.97, -173.02 -157.2, 114.58 191.51, 14.84 -90.61, 158.12 297.06, 102.49 67.12, -99.7 in-in in 8.631 Saltbr-in 2.727 HRD-in -74.0, -48.74 85.04, -22.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -168.99 APE9-dihe-na -96.92, -27.66 APE8-dihe-in -82.09, 127.1 APE8-rot-out 70.19 APE67-dihe-in -70.58, -23.59 -96.42, -0.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.637 APE9-dist-out 10.787 None None None XRAY 2.4 0.228 0.246 B 299 247 25 0 0 16 [[356, 616]] 1.0 9p6a STE_MAP3K2_HUMAN STE 1.9e-81 279.1 1 257 257 500 501 502 504 506 385 406 410 480 482 481 483 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2
TKL BRAF BRAF_HUMAN 6P3DA P15056 448 721 766.0 0LI:61001 Type2 Inactive DFGout 12.35 10.905 BBAminus DFGAsp-rot-in -138.54, -166.92 -135.05, 80.45 200.94, -2.79 -80.66, -37.84 293.17, 97.28 81.0, 10.25 in-in in 8.665 Saltbr-in 2.997 HRD-in -65.6, -55.77 77.59, -19.55 in-out-out SNCioo out-out ActLoopNT-out 19.945 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -19.82 APE9-dihe-na 76.62, -63.3 APE8-dihe-out -51.89, -23.77 APE8-rot-out 78.9 APE67-dihe-in -55.73, -23.59 -56.01, -24.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.7 APE9-dist-out 11.871 None None None XRAY 2.11 0.188 0.245 A 297 261 13 0 0 13 [[457, 716]] 1.0 6p3d TKL_BRAF_HUMAN TKL 6e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 6EG9A Q9NWZ3 164 459 460.0 0LI:501 Type2 Inactive DFGout 14.071 10.716 None DFGAsp-rot-in -127.45, 167.3 -138.69, 101.47 183.13, 30.86 -85.85, 140.23 309.7, 100.41 -43.19, 999.0 in-out in 9.027 Saltbr-out 6.646 HRD-in -71.51, -48.43 70.86, -5.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 6.91 APE9-dihe-na 158.59, -165.8 APE8-dihe-in -114.99, 116.82 APE8-rot-in 299.55 APE67-dihe-in -67.65, -20.43 -63.19, -29.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.972 None None None XRAY 2.414 0.224 0.249 A 312 276 20 0 0 17 [[183, 456]] 1.0 6eg9 TKL_IRAK4_HUMAN TKL 4.8e-84 288.0 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EG9B Q9NWZ3 165 459 460.0 0LI:501 Type2 Inactive DFGout 14.244 9.395 None DFGAsp-rot-in -135.81, 174.82 -152.29, 126.78 182.09, 43.03 -163.75, 999.0 33.58, 60.29 999.0, 999.0 in-in in 8.979 Saltbr-in 3.09 HRD-in -69.81, -51.27 77.39, -7.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 146.5 APE9-dihe-na 95.5, 175.38 APE8-dihe-in -117.78, 118.94 APE8-rot-in 307.93 APE67-dihe-in -67.02, -18.64 -61.22, -30.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.63 None None None XRAY 2.414 0.224 0.249 B 312 274 21 0 0 18 [[183, 456]] 1.0 6eg9 TKL_IRAK4_HUMAN TKL 4.8e-84 288.0 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL LRRK2 LRRK2_HUMAN 8U8AB Q5S007 558 2526 2527.0 0LI:2601 Type2 Inactive DFGout 14.859 10.845 BBAminus DFGAsp-rot-none -150.37, 144.32 -124.19, 97.68 999.0, 999.0 -69.79, -11.11 321.73, 111.63 66.57, 27.33 in-out in 8.874 Saltbr-out 3.673 HRD-out -76.07, 95.41 -48.17, -63.17 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 177.03 APE8-dihe-in -61.6, 136.03 APE8-rot-in 305.18 APE67-dihe-in -74.33, -25.33 -56.72, -44.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.297 None None None EM 3.4 999.0 999.0 B 2527 1705 29 0 0 13 [[1875, 2134]] 1.0 8u8a TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8U8AC Q5S007 558 2526 2527.0 0LI:2601 Type2 Inactive DFGout 14.87 10.846 BBAminus DFGAsp-rot-none -150.46, 144.31 -124.23, 97.69 999.0, 999.0 -69.77, -11.06 321.78, 111.5 66.48, 27.35 in-out in 8.872 Saltbr-out 3.661 HRD-out -76.02, 95.48 -48.33, -63.13 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 177.01 APE8-dihe-in -61.57, 135.98 APE8-rot-in 305.14 APE67-dihe-in -74.37, -25.35 -56.73, -44.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.301 None None None EM 3.4 999.0 999.0 C 2527 1705 29 0 0 13 [[1875, 2134]] 1.0 8u8a TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 4C8BA O43353 8 316 540.0 0LI:1000 Type2 Inactive DFGout 12.729 8.584 None DFGAsp-rot-in -142.99, -175.55 -154.35, 140.4 192.78, 18.19 -129.56, 999.0 290.55, 114.67 999.0, 999.0 in-in in 8.243 Saltbr-in 2.817 HRD-in -79.84, -58.2 64.89, 19.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.9 APE8-dihe-out -84.71, -55.98 APE8-rot-none 999.0 APE67-dihe-in -64.98, -25.64 -68.13, -16.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.294 None None None XRAY 2.75 0.203 0.244 A 334 279 30 0 0 22 [[18, 292]] 1.0 4c8b TKL_RIPK2_HUMAN TKL 3.5e-73 252.4 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 4C8BB O43353 9 316 540.0 0LI:1000 Type2 Inactive DFGout 12.84 8.86 None DFGAsp-rot-in -140.63, -176.63 -153.18, 138.54 191.39, 19.69 -119.75, 999.0 285.35, 113.34 999.0, 999.0 in-in in 8.264 Saltbr-in 2.806 HRD-in -79.98, -59.74 66.42, 17.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -39.27 APE8-dihe-out -68.6, -38.75 APE8-rot-out 169.06 APE67-dihe-in -64.78, -24.38 -61.46, -15.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.445 None None None XRAY 2.75 0.203 0.244 B 334 281 27 0 0 22 [[18, 292]] 1.0 4c8b TKL_RIPK2_HUMAN TKL 3.5e-73 252.4 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TYR DDR1 DDR1_HUMAN 3ZOSB Q08345 601 913 913.0 0LI:61000 Type2 Inactive DFGout 13.646 9.63 BBAminus DFGAsp-rot-in -143.84, 178.94 -153.3, 114.42 182.74, 4.4 -82.71, -15.18 287.49, 108.73 52.14, -127.46 in-in in 7.96 Saltbr-in 2.883 HRD-in -60.43, -59.89 83.25, -8.8 in-out-in SNCioi out-in ActLoopNT-out 17.4 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -109.91, 133.24 APE9-dihe-in -130.81, 142.32 APE8-dihe-in -80.63, 68.61 APE8-rot-na 30.08 APE67-dihe-in -67.12, -16.99 -59.3, -31.33 APE12-dist-na 11.719 APE11-dist-na 12.939 APE10-dist-na 10.223 APE9-dist-na 7.924 None None None XRAY 1.92 0.208 0.234 B 315 301 12 0 0 0 [[610, 907]] 1.0 3zos TYR_DDR1_HUMAN TYR 1.6e-92 315.5 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 3ZOSA Q08345 602 913 913.0 0LI:61000,0LI:61004 Type2,Allosteric Inactive DFGout 13.684 9.765 BBAminus DFGAsp-rot-in -140.01, 179.9 -153.22, 112.84 182.89, 5.53 -85.26, -13.51 285.68, 107.96 48.92, -126.09 in-in in 7.998 Saltbr-in 2.881 HRD-in -61.25, -58.95 80.5, -7.41 in-out-in SNCioi out-in ActLoopNT-out 17.476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -117.17, 140.69 APE9-dihe-in -129.43, 143.43 APE8-dihe-in -82.4, 69.11 APE8-rot-na 29.15 APE67-dihe-in -67.51, -15.14 -58.33, -33.07 APE12-dist-na 11.707 APE11-dist-na 12.385 APE10-dist-na 10.171 APE9-dist-na 7.92 None None None XRAY 1.92 0.208 0.234 A 315 301 11 0 0 0 [[610, 907]] 1.0 3zos TYR_DDR1_HUMAN TYR 1.6e-92 315.5 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR EGFR EGFR_HUMAN 9GHVA P00533 697 1018 1210.0 A1ILI:1101 Type1 Active DFGin 5.625 13.893 BLAminus DFGAsp-rot-in -150.7759, -170.618 59.2144, 90.1545 194.127, -2.2232 -104.9958, 33.0501 297.609, 90.6358 -67.5326, -24.0428 in-in in 8.153 Saltbr-in 2.521 HRD-in -70.6886, -49.0536 71.0467, 3.0794 in-in-in SNCiii in-in ActLoopNT-in 2.932 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -71.4575, 123.5997 APE9-dihe-in -130.9049, 141.8358 APE8-dihe-in -63.25, 110.7872 APE8-rot-na 20.5195 APE67-dihe-in -73.6775, -4.015 -65.1729, -42.6785 APE12-dist-na 11.765 APE11-dist-na 9.892 APE10-dist-na 10.54 APE9-dist-na 6.333 None None None XRAY 2.5 0.191 0.213 A 333 299 3 0 0 0 [[712, 970]] 1.0 9ghv TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR FGFR1 FGFR1_HUMAN 4V04B P11362 458 765 822.0 0LI:1771 Type2 Inactive DFGout 13.974 9.873 BBAminus DFGAsp-rot-in -127.4, -173.98 -164.99, 120.92 182.09, 75.09 -104.35, 44.71 306.97, 107.67 29.41, -12.23 in-in in 7.692 Saltbr-in 3.015 HRD-in -72.1, -51.88 81.11, -15.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -102.55, 155.16 APE9-dihe-in -98.03, 109.95 APE8-dihe-out -52.12, -21.56 APE8-rot-na 329.22 APE67-dihe-in -70.06, -7.36 -58.08, -24.0 APE12-dist-na 19.514 APE11-dist-na 20.97 APE10-dist-na 19.298 APE9-dist-na 11.591 C488A,C584S None None XRAY 2.12 0.188 0.228 B 309 289 19 0 0 6 [[478, 756]] 1.0 4v04 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4V01A P11362 465 765 822.0 0LI:1776 Type2 Inactive DFGout 13.648 9.683 None DFGAsp-rot-in -136.22, -176.63 -157.46, 111.62 191.59, 16.37 -99.01, 999.0 301.26, 98.54 999.0, 999.0 in-in in 7.852 Saltbr-in 2.824 HRD-in -71.33, -57.3 83.26, -24.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -104.02, 147.14 APE9-dihe-in -94.17, 112.67 APE8-dihe-out -54.82, -21.48 APE8-rot-na 334.27 APE67-dihe-in -70.4, -11.17 -58.27, -24.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 11.727 C488A,C584S None None XRAY 2.33 0.191 0.238 A 309 273 28 0 0 8 [[478, 756]] 1.0 4v01 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4V01B P11362 461 763 822.0 0LI:1770 Type2 Inactive DFGout 13.476 9.083 None DFGAsp-rot-in -140.66, -178.05 -156.06, 123.42 194.99, 33.65 -117.89, 999.0 302.59, 94.37 999.0, 999.0 in-in in 7.916 Saltbr-in 2.807 HRD-in -63.92, -54.57 77.31, -15.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -101.11, 164.12 APE9-dihe-in -107.61, 109.54 APE8-dihe-out -56.39, -11.31 APE8-rot-na 332.13 APE67-dihe-in -66.82, -7.77 -66.39, -26.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 11.814 C488A,C584S None None XRAY 2.33 0.191 0.238 B 309 275 28 0 0 8 [[478, 756]] 1.0 4v01 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4V04A P11362 463 765 822.0 0LI:1772 Type2 Inactive DFGout 14.051 10.394 None DFGAsp-rot-in -127.25, -179.24 -145.47, 116.11 187.36, 48.8 -167.94, 35.9 26.55, 54.39 23.93, -5.2 in-in in 7.864 Saltbr-in 3.206 HRD-in -65.2, -58.04 83.28, -16.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -102.41, 155.12 APE9-dihe-in -98.09, 110.26 APE8-dihe-out -52.77, -21.99 APE8-rot-na 329.65 APE67-dihe-in -70.41, -8.08 -56.89, -24.83 APE12-dist-na 19.639 APE11-dist-na 21.02 APE10-dist-na 19.322 APE9-dist-na 11.7 C488A,C584S None None XRAY 2.12 0.188 0.228 A 309 293 10 0 0 6 [[478, 756]] 1.0 4v04 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR4 FGFR4_HUMAN 4UXQA P22455 452 750 802.0 0LI:1752 Type2 Inactive DFGout 13.289 9.688 BBAminus DFGAsp-rot-in -132.52, -175.6 -154.98, 108.32 175.58, 45.21 -101.68, -37.05 301.67, 99.59 -82.32, -172.58 in-in in 7.813 Saltbr-in 2.727 HRD-in -74.83, -56.93 88.13, -22.48 in-out-out SNCioo out-out ActLoopNT-out 15.96 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -78.09, 139.64 APE9-dihe-in -109.24, 95.28 APE8-dihe-out -52.11, -28.25 APE8-rot-na 327.58 APE67-dihe-in -73.35, -9.88 -60.02, -19.19 APE12-dist-na 12.227 APE11-dist-na 12.924 APE10-dist-na 10.113 APE9-dist-na 11.612 C477A None None XRAY 1.85 0.205 0.268 A 309 286 13 0 0 0 [[467, 745]] 1.0 4uxq TYR_FGFR4_HUMAN TYR 8.4e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 4TYJA P22455 447 753 802.0 0LI:60801 Type2 Inactive DFGout 13.629 9.602 BBAminus DFGAsp-rot-in -136.8, -177.28 -149.4, 114.79 188.8, 20.21 -98.18, 9.17 298.44, 103.78 79.91, -171.4 in-in in 7.82 Saltbr-in 2.757 HRD-in -71.95, -55.51 84.74, -19.01 in-out-none SNCion out-none ActLoopNT-out 19.108 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.68 APE8-dihe-in -83.91, 64.17 APE8-rot-na 36.55 APE67-dihe-in -73.09, -8.81 -53.35, -41.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.819 None None None XRAY 2.45 0.217 0.247 A 311 275 32 0 0 15 [[467, 745]] 1.0 4tyj TYR_FGFR4_HUMAN TYR 1.3e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 4QRCA P22455 454 750 802.0 0LI:802 Type2 Inactive DFGout 13.848 9.448 None DFGAsp-rot-out -128.93, 176.89 -168.87, 140.49 44.1, -25.9 58.84, 41.6 314.29, 151.03 128.95, 161.76 in-in in 7.269 Saltbr-in 2.545 HRD-in -73.23, -52.1 79.8, -10.52 in-out-out SNCioo out-out ActLoopNT-out 8.662 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -79.02, 138.09 APE9-dihe-in -108.95, 92.74 APE8-dihe-out -61.85, -18.49 APE8-rot-na 333.49 APE67-dihe-in -72.31, -7.32 -59.05, -24.57 APE12-dist-na 19.537 APE11-dist-na 21.047 APE10-dist-na 16.873 APE9-dist-na 12.017 C477A,R664E None None XRAY 1.901 0.173 0.207 A 323 297 0 0 0 0 [[467, 745]] 1.0 4qrc TYR_FGFR4_HUMAN TYR 1.6e-100 341.7 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR KIT KIT_HUMAN 8S17A P10721 567 931 976.0 0LI:61001 Type2 Inactive DFGout 15.425 9.951 BBAminus DFGAsp-rot-in -145.25, 179.39 -143.98, 106.64 190.84, 54.02 -67.34, -40.16 274.67, 96.68 58.73, -115.03 in-in in 7.749 Saltbr-in 2.696 HRD-in -73.68, -54.05 81.88, -13.47 in-out-in SNCioi out-in ActLoopNT-out 16.311 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -118.0, 112.95 APE9-dihe-in -124.02, 150.83 APE8-dihe-in -80.03, 74.01 APE8-rot-na 32.18 APE67-dihe-in -67.91, -14.83 -61.86, -40.28 APE12-dist-na 16.635 APE11-dist-na 13.202 APE10-dist-na 11.515 APE9-dist-na 7.701 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.2 0.203 0.228 A 327 287 0 0 0 0 [[589, 926]] 1.0 8s17 TYR_KIT_HUMAN TYR 2.4e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8S17B P10721 578 931 976.0 0LI:61001 Type2 Inactive DFGout 15.227 9.879 BBAminus DFGAsp-rot-in -145.11, 172.96 -138.62, 103.76 193.48, 29.52 -65.65, -38.27 276.93, 92.02 61.53, -118.4 in-in in 7.652 Saltbr-in 2.743 HRD-in -69.78, -55.3 82.77, -9.47 in-out-in SNCioi out-in ActLoopNT-out 16.408 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -113.26, 116.47 APE9-dihe-in -128.18, 149.58 APE8-dihe-in -80.46, 72.63 APE8-rot-na 32.73 APE67-dihe-in -67.64, -17.39 -58.96, -38.89 APE12-dist-na 16.505 APE11-dist-na 13.309 APE10-dist-na 11.718 APE9-dist-na 7.975 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.2 0.203 0.228 B 327 276 0 0 0 0 [[589, 926]] 1.0 8s17 TYR_KIT_HUMAN TYR 2.4e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 4U0IA P10721 565 933 976.0 0LI:1001 Type2 Inactive DFGout 15.152 9.758 BBAminus DFGAsp-rot-in -145.62, -174.19 -155.03, 115.98 196.58, -2.01 -76.91, -26.31 285.47, 90.73 51.17, -116.44 in-in in 7.686 Saltbr-in 2.619 HRD-in -74.87, -53.81 79.28, -20.01 in-out-in SNCioi out-in ActLoopNT-out 16.446 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -94.86, 120.83 APE9-dihe-in -126.16, 149.12 APE8-dihe-in -78.54, 70.26 APE8-rot-na 32.2 APE67-dihe-in -61.59, -16.21 -59.65, -43.09 APE12-dist-na 17.193 APE11-dist-na 14.015 APE10-dist-na 12.164 APE9-dist-na 7.681 None None None XRAY 2.0 0.204 0.239 A 315 297 12 0 0 0 [[589, 926]] 1.0 4u0i TYR_KIT_HUMAN TYR 3.9e-102 347.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR ROR1 ROR1_HUMAN 6TU9A Q01973 460 749 937.0 0LI:801 Type1 Pseudo None 999.0 999.0 None DFGAsp-rot-in -143.45, 175.76 -148.29, 81.04 193.55, 11.09 -104.43, 119.64 999.0, 999.0 -53.65, -7.79 in-in in 8.227 Saltbr-in 2.725 HRD-in -69.35, -57.72 81.6, -11.35 in-out-in SNCioi out-in ActLoopNT-out 15.395 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -88.59, 129.49 APE9-dihe-in -125.15, 133.19 APE8-dihe-in -78.4, 68.8 APE8-rot-na 36.93 APE67-dihe-in -68.17, -18.18 -55.42, -35.07 APE12-dist-na 999.0 APE11-dist-na 15.69 APE10-dist-na 11.605 APE9-dist-na 6.992 None None None XRAY 1.94 0.21 0.241 A 306 268 22 0 0 4 [[473, 748]] 1.0 6tu9 TYR_ROR1_HUMAN TYR 1.2e-94 322.4 2 260 259 632 633 634 636 638 506 523 527 612 614 613 615 674 662 657 656 655 654 653 652 651 553 Inactive tyrosine-protein kinase transmembrane receptor ROR1
TYR ROR1 ROR1_HUMAN 6TU9B Q01973 465 750 937.0 0LI:801 Type1 Pseudo None 999.0 999.0 None DFGAsp-rot-in -143.03, 176.7 -144.7, 81.77 189.61, 21.61 -85.65, -31.03 999.0, 999.0 92.49, -44.82 in-in in 8.283 Saltbr-in 2.974 HRD-in -64.86, -61.91 82.91, -9.99 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -100.96, 129.63 APE9-dihe-in -119.15, 127.45 APE8-dihe-in -76.72, 68.52 APE8-rot-na 33.66 APE67-dihe-in -67.05, -20.69 -57.04, -32.64 APE12-dist-na 17.025 APE11-dist-na 15.144 APE10-dist-na 11.197 APE9-dist-na 6.97 None None None XRAY 1.94 0.21 0.241 B 306 261 25 0 0 2 [[473, 748]] 1.0 6tu9 TYR_ROR1_HUMAN TYR 1.2e-94 322.4 2 260 259 632 633 634 636 638 506 523 527 612 614 613 615 674 662 657 656 655 654 653 652 651 553 Inactive tyrosine-protein kinase transmembrane receptor ROR1
TYR SRC SRC_HUMAN 7OTEA P12931 261 536 536.0 0LI:601 Type2 Inactive DFGout 13.678 9.025 BBAminus DFGAsp-rot-in -119.79, 176.26 -136.22, 145.66 213.09, 14.46 -117.56, 59.41 289.7, 90.17 173.51, 999.0 in-in in 7.879 Saltbr-in 2.532 HRD-in -78.56, -49.16 85.49, -24.96 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 150.65 APE8-dihe-in -61.46, 92.79 APE8-rot-na 30.48 APE67-dihe-in -70.25, -17.48 -54.65, -43.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.618 None None None XRAY 2.49 0.179 0.252 A 293 259 17 0 0 17 [[270, 521]] 1.0 7ote TYR_SRC_HUMAN TYR 1.8e-94 321.9 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 7OTEB P12931 261 536 536.0 0LI:601 Type2 Inactive DFGout 14.508 9.181 BBAminus DFGAsp-rot-in -149.51, 179.45 -147.71, 103.83 202.03, -42.09 -80.1, -7.38 295.65, 135.68 68.38, 999.0 in-out in 8.912 Saltbr-out 4.135 HRD-in -81.29, -57.98 98.12, -42.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.79 APE8-dihe-in -102.78, 62.88 APE8-rot-na 39.14 APE67-dihe-in -65.77, -18.22 -41.35, -46.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 9.298 None None None XRAY 2.49 0.179 0.252 B 293 259 17 0 0 17 [[270, 521]] 1.0 7ote TYR_SRC_HUMAN TYR 1.8e-94 321.9 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src

Ligand: LI

Total number of chains: 35
Active chains: 2
Total number of genes: 16
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 19 54.3% 3IK3B
DFGout None 9 25.7% 4QRCA
DFGin BLAminus 4 11.4% 4DTKA
None None 2 5.7% 6TU9A
DFGin BLBtrans 1 2.9% 9QVZA
All chains
Pymol session (all) Pymol script (all)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 7WF5A P00523 257 533 533.0 0LI:601 Type2 Inactive DFGout 13.293 8.853 BBAminus DFGAsp-rot-in -138.86, 178.47 -148.72, 117.06 191.24, -2.56 -103.55, 7.74 290.87, 100.32 61.55, 53.93 in-in in 7.671 Saltbr-in 2.617 HRD-in -81.35, -59.57 92.68, -15.97 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.23 APE8-dihe-in -80.1, 61.84 APE8-rot-na 34.61 APE67-dihe-in -62.67, -20.24 -53.79, -38.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 9.003 None None None XRAY 1.798 0.163 0.183 A 286 261 16 0 0 16 [[267, 518]] 1.0 7wf5 Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 7WF5B P00523 254 533 533.0 0LI:601 Type2 Inactive DFGout 13.337 8.808 BBAminus DFGAsp-rot-in -139.72, 178.97 -149.88, 114.3 190.37, -1.99 -104.08, 8.92 292.96, 104.73 64.81, 53.74 in-in in 7.856 Saltbr-in 2.792 HRD-in -81.76, -58.24 93.94, -19.23 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.23 APE8-dihe-in -81.79, 58.44 APE8-rot-na 33.89 APE67-dihe-in -61.6, -25.83 -54.2, -35.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 9.562 None None None XRAY 1.798 0.163 0.183 B 286 265 15 0 0 15 [[267, 518]] 1.0 7wf5 Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
CAMK AURKA AURKA_HUMAN 9QVZA O14965 124 390 403.0 ADP:501,LI:506 ATPlike,Allosteric Inactive DFGin 6.104 17.565 BLBtrans DFGAsp-rot-out -120.9348, -175.2925 52.6829, 52.4808 290.9234, 60.3612 -81.4885, 60.9708 219.9237, 106.9888 -92.5523, 91.9137 out-out out 10.467 Saltbr-out 4.251 HRD-in -65.2039, -55.0867 57.7579, 30.8856 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -164.2282, 150.125 APE9-dihe-na 128.8633, 144.1058 APE8-dihe-in -91.8178, 126.6478 APE8-rot-in 308.2626 APE67-dihe-in -58.8199, -19.121 -57.7541, -46.5905 APE12-dist-in 13.234 APE11-dist-in 13.13 APE10-dist-out 8.652 APE9-dist-in 5.069 C290A,C393A None None XRAY 2.39 0.294 0.336 A 285 254 13 0 0 10 [[133, 383]] 1.0 9qvz Homo sapiens CAMK_AURKA_HUMAN CAMK 9.7e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK PIM1 PIM1_HUMAN 4DTKA P11309 33 305 313.0 7LI:408 Type1 Active DFGin 6.142 14.661 BLAminus DFGAsp-rot-in -128.39, 173.69 63.23, 87.87 199.22, -2.97 -95.85, 17.29 285.67, 80.15 -64.1, -18.22 in-in in 8.861 Saltbr-in 2.588 HRD-na-A -66.25, -50.01 70.2, 5.45 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.52, 26.77 APE9-dihe-na -86.23, -154.0 APE8-dihe-in -89.22, 120.59 APE8-rot-in 306.1 APE67-dihe-in -65.85, -11.4 -53.32, -45.84 APE12-dist-in 9.701 APE11-dist-in 8.585 APE10-dist-in 5.474 APE9-dist-in 3.692 None None None XRAY 1.86 0.166 0.182 A 276 273 0 0 0 0 [[38, 290]] 1.0 4dtk Homo sapiens CAMK_PIM1_HUMAN CAMK 2.6e-65 226.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CMGC DYRK1A DYR1A_HUMAN 7O7KA Q13627 134 480 763.0 6ZV:803,LI:813 Type1,Allosteric Inactive DFGin 7.479 14.978 BLAminus DFGAsp-rot-in -123.84, 172.32 71.95, 80.41 186.45, 22.97 -97.61, 20.16 282.45, 81.55 -75.41, -18.82 in-in in 8.732 Saltbr-in 2.569 HRD-in -66.95, -44.76 74.49, -2.2 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.45, 171.41 APE9-dihe-na 76.66, 152.25 APE8-dihe-in -71.23, 142.04 APE8-rot-out 204.57 APE67-dihe-in -61.2, -25.53 -57.62, -46.09 APE12-dist-in 13.826 APE11-dist-in 12.396 APE10-dist-in 7.934 APE9-dist-in 3.209 None PTR321 PTR321 XRAY 1.82 0.179 0.205 A 361 345 2 0 0 0 [[159, 479]] 1.0 7o7k Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.7e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7O7KB Q13627 133 480 763.0 6ZV:504,LI:516 Type1,Allosteric Inactive DFGin 7.549 15.002 BLAminus DFGAsp-rot-in -123.44, 173.38 69.65, 80.66 189.78, 20.14 -97.78, 19.84 280.19, 88.12 -76.56, -16.84 in-in in 8.721 Saltbr-in 2.45 HRD-in -66.14, -44.61 73.06, -2.94 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -122.41, 168.28 APE9-dihe-na 77.46, 151.66 APE8-dihe-in -70.04, 138.71 APE8-rot-out 178.34 APE67-dihe-in -60.28, -25.12 -56.13, -47.11 APE12-dist-in 13.885 APE11-dist-in 12.364 APE10-dist-out 8.042 APE9-dist-in 3.108 None PTR321 PTR321 XRAY 1.82 0.179 0.205 B 361 345 3 0 0 0 [[159, 479]] 1.0 7o7k Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.7e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
STE MAP3K2 M3K2_HUMAN 9P6AA Q9Y2U5 351 617 619.0 0LI:701 Type2 Inactive DFGout 14.143 9.891 BBAminus DFGAsp-rot-in -146.02, -172.59 -157.95, 116.33 191.45, 14.99 -87.88, -36.33 294.81, 102.45 -88.54, 36.79 in-in in 8.458 Saltbr-in 2.594 HRD-in -76.59, -52.31 80.62, -19.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.17, -51.62 APE9-dihe-na -96.01, 162.48 APE8-dihe-in -81.48, 131.06 APE8-rot-out 69.69 APE67-dihe-in -67.88, -22.22 -92.28, 3.15 APE12-dist-out 20.682 APE11-dist-out 19.144 APE10-dist-out 14.309 APE9-dist-out 10.456 None None None XRAY 2.4 0.228 0.246 A 299 253 14 0 0 14 [[356, 616]] 1.0 9p6a Homo sapiens STE_MAP3K2_HUMAN STE 1.9e-81 279.1 1 257 257 500 501 502 504 506 385 406 410 480 482 481 483 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2
STE MAP3K2 M3K2_HUMAN 9P6AB Q9Y2U5 347 618 619.0 0LI:701 Type2 Inactive DFGout 13.802 9.756 None DFGAsp-rot-in -145.97, -173.02 -157.2, 114.58 191.51, 14.84 -90.61, 158.12 297.06, 102.49 67.12, -99.7 in-in in 8.631 Saltbr-in 2.727 HRD-in -74.0, -48.74 85.04, -22.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -168.99 APE9-dihe-na -96.92, -27.66 APE8-dihe-in -82.09, 127.1 APE8-rot-out 70.19 APE67-dihe-in -70.58, -23.59 -96.42, -0.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.637 APE9-dist-out 10.787 None None None XRAY 2.4 0.228 0.246 B 299 247 25 0 0 16 [[356, 616]] 1.0 9p6a Homo sapiens STE_MAP3K2_HUMAN STE 1.9e-81 279.1 1 257 257 500 501 502 504 506 385 406 410 480 482 481 483 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2
TKL BRAF BRAF_HUMAN 6P3DA P15056 448 721 766.0 0LI:61001 Type2 Inactive DFGout 12.35 10.905 BBAminus DFGAsp-rot-in -138.54, -166.92 -135.05, 80.45 200.94, -2.79 -80.66, -37.84 293.17, 97.28 81.0, 10.25 in-in in 8.665 Saltbr-in 2.997 HRD-in -65.6, -55.77 77.59, -19.55 in-out-out SNCioo out-out ActLoopNT-out 19.945 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -19.82 APE9-dihe-na 76.62, -63.3 APE8-dihe-out -51.89, -23.77 APE8-rot-out 78.9 APE67-dihe-in -55.73, -23.59 -56.01, -24.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.7 APE9-dist-out 11.871 None None None XRAY 2.11 0.188 0.245 A 297 261 13 0 0 13 [[457, 716]] 1.0 6p3d Homo sapiens TKL_BRAF_HUMAN TKL 6e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 6EG9A Q9NWZ3 164 459 460.0 0LI:501 Type2 Inactive DFGout 14.071 10.716 None DFGAsp-rot-in -127.45, 167.3 -138.69, 101.47 183.13, 30.86 -85.85, 140.23 309.7, 100.41 -43.19, 999.0 in-out in 9.027 Saltbr-out 6.646 HRD-in -71.51, -48.43 70.86, -5.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 6.91 APE9-dihe-na 158.59, -165.8 APE8-dihe-in -114.99, 116.82 APE8-rot-in 299.55 APE67-dihe-in -67.65, -20.43 -63.19, -29.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.972 None None None XRAY 2.414 0.224 0.249 A 312 276 20 0 0 17 [[183, 456]] 1.0 6eg9 Homo sapiens TKL_IRAK4_HUMAN TKL 4.8e-84 288.0 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EG9B Q9NWZ3 165 459 460.0 0LI:501 Type2 Inactive DFGout 14.244 9.395 None DFGAsp-rot-in -135.81, 174.82 -152.29, 126.78 182.09, 43.03 -163.75, 999.0 33.58, 60.29 999.0, 999.0 in-in in 8.979 Saltbr-in 3.09 HRD-in -69.81, -51.27 77.39, -7.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 146.5 APE9-dihe-na 95.5, 175.38 APE8-dihe-in -117.78, 118.94 APE8-rot-in 307.93 APE67-dihe-in -67.02, -18.64 -61.22, -30.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.63 None None None XRAY 2.414 0.224 0.249 B 312 274 21 0 0 18 [[183, 456]] 1.0 6eg9 Homo sapiens TKL_IRAK4_HUMAN TKL 4.8e-84 288.0 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL LRRK2 LRRK2_HUMAN 8U8AB Q5S007 558 2526 2527.0 0LI:2601 Type2 Inactive DFGout 14.859 10.845 BBAminus DFGAsp-rot-none -150.37, 144.32 -124.19, 97.68 999.0, 999.0 -69.79, -11.11 321.73, 111.63 66.57, 27.33 in-out in 8.874 Saltbr-out 3.673 HRD-out -76.07, 95.41 -48.17, -63.17 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 177.03 APE8-dihe-in -61.6, 136.03 APE8-rot-in 305.18 APE67-dihe-in -74.33, -25.33 -56.72, -44.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.297 None None None EM 3.4 999.0 999.0 B 2527 1705 29 0 0 13 [[1875, 2134]] 1.0 8u8a Homo sapiens TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8U8AC Q5S007 558 2526 2527.0 0LI:2601 Type2 Inactive DFGout 14.87 10.846 BBAminus DFGAsp-rot-none -150.46, 144.31 -124.23, 97.69 999.0, 999.0 -69.77, -11.06 321.78, 111.5 66.48, 27.35 in-out in 8.872 Saltbr-out 3.661 HRD-out -76.02, 95.48 -48.33, -63.13 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 177.01 APE8-dihe-in -61.57, 135.98 APE8-rot-in 305.14 APE67-dihe-in -74.37, -25.35 -56.73, -44.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.301 None None None EM 3.4 999.0 999.0 C 2527 1705 29 0 0 13 [[1875, 2134]] 1.0 8u8a Homo sapiens TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 4C8BA O43353 8 316 540.0 0LI:1000 Type2 Inactive DFGout 12.729 8.584 None DFGAsp-rot-in -142.99, -175.55 -154.35, 140.4 192.78, 18.19 -129.56, 999.0 290.55, 114.67 999.0, 999.0 in-in in 8.243 Saltbr-in 2.817 HRD-in -79.84, -58.2 64.89, 19.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.9 APE8-dihe-out -84.71, -55.98 APE8-rot-none 999.0 APE67-dihe-in -64.98, -25.64 -68.13, -16.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.294 None None None XRAY 2.75 0.203 0.244 A 334 279 30 0 0 22 [[18, 292]] 1.0 4c8b Homo sapiens TKL_RIPK2_HUMAN TKL 3.5e-73 252.4 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 4C8BB O43353 9 316 540.0 0LI:1000 Type2 Inactive DFGout 12.84 8.86 None DFGAsp-rot-in -140.63, -176.63 -153.18, 138.54 191.39, 19.69 -119.75, 999.0 285.35, 113.34 999.0, 999.0 in-in in 8.264 Saltbr-in 2.806 HRD-in -79.98, -59.74 66.42, 17.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -39.27 APE8-dihe-out -68.6, -38.75 APE8-rot-out 169.06 APE67-dihe-in -64.78, -24.38 -61.46, -15.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.445 None None None XRAY 2.75 0.203 0.244 B 334 281 27 0 0 22 [[18, 292]] 1.0 4c8b Homo sapiens TKL_RIPK2_HUMAN TKL 3.5e-73 252.4 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TYR DDR1 DDR1_HUMAN 3ZOSB Q08345 601 913 913.0 0LI:61000 Type2 Inactive DFGout 13.646 9.63 BBAminus DFGAsp-rot-in -143.84, 178.94 -153.3, 114.42 182.74, 4.4 -82.71, -15.18 287.49, 108.73 52.14, -127.46 in-in in 7.96 Saltbr-in 2.883 HRD-in -60.43, -59.89 83.25, -8.8 in-out-in SNCioi out-in ActLoopNT-out 17.4 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -109.91, 133.24 APE9-dihe-in -130.81, 142.32 APE8-dihe-in -80.63, 68.61 APE8-rot-na 30.08 APE67-dihe-in -67.12, -16.99 -59.3, -31.33 APE12-dist-na 11.719 APE11-dist-na 12.939 APE10-dist-na 10.223 APE9-dist-na 7.924 None None None XRAY 1.92 0.208 0.234 B 315 301 12 0 0 0 [[610, 907]] 1.0 3zos Homo sapiens TYR_DDR1_HUMAN TYR 1.6e-92 315.5 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 3ZOSA Q08345 602 913 913.0 0LI:61000,0LI:61004 Type2,Allosteric Inactive DFGout 13.684 9.765 BBAminus DFGAsp-rot-in -140.01, 179.9 -153.22, 112.84 182.89, 5.53 -85.26, -13.51 285.68, 107.96 48.92, -126.09 in-in in 7.998 Saltbr-in 2.881 HRD-in -61.25, -58.95 80.5, -7.41 in-out-in SNCioi out-in ActLoopNT-out 17.476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -117.17, 140.69 APE9-dihe-in -129.43, 143.43 APE8-dihe-in -82.4, 69.11 APE8-rot-na 29.15 APE67-dihe-in -67.51, -15.14 -58.33, -33.07 APE12-dist-na 11.707 APE11-dist-na 12.385 APE10-dist-na 10.171 APE9-dist-na 7.92 None None None XRAY 1.92 0.208 0.234 A 315 301 11 0 0 0 [[610, 907]] 1.0 3zos Homo sapiens TYR_DDR1_HUMAN TYR 1.6e-92 315.5 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR EGFR EGFR_HUMAN 9GHVA P00533 697 1018 1210.0 A1ILI:1101 Type1 Active DFGin 5.625 13.893 BLAminus DFGAsp-rot-in -150.7759, -170.618 59.2144, 90.1545 194.127, -2.2232 -104.9958, 33.0501 297.609, 90.6358 -67.5326, -24.0428 in-in in 8.153 Saltbr-in 2.521 HRD-in -70.6886, -49.0536 71.0467, 3.0794 in-in-in SNCiii in-in ActLoopNT-in 2.932 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -71.4575, 123.5997 APE9-dihe-in -130.9049, 141.8358 APE8-dihe-in -63.25, 110.7872 APE8-rot-na 20.5195 APE67-dihe-in -73.6775, -4.015 -65.1729, -42.6785 APE12-dist-na 11.765 APE11-dist-na 9.892 APE10-dist-na 10.54 APE9-dist-na 6.333 None None None XRAY 2.5 0.191 0.213 A 333 299 3 0 0 0 [[712, 970]] 1.0 9ghv Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR FGFR1 FGFR1_HUMAN 4V04B P11362 458 765 822.0 0LI:1771 Type2 Inactive DFGout 13.974 9.873 BBAminus DFGAsp-rot-in -127.4, -173.98 -164.99, 120.92 182.09, 75.09 -104.35, 44.71 306.97, 107.67 29.41, -12.23 in-in in 7.692 Saltbr-in 3.015 HRD-in -72.1, -51.88 81.11, -15.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -102.55, 155.16 APE9-dihe-in -98.03, 109.95 APE8-dihe-out -52.12, -21.56 APE8-rot-na 329.22 APE67-dihe-in -70.06, -7.36 -58.08, -24.0 APE12-dist-na 19.514 APE11-dist-na 20.97 APE10-dist-na 19.298 APE9-dist-na 11.591 C488A,C584S None None XRAY 2.12 0.188 0.228 B 309 289 19 0 0 6 [[478, 756]] 1.0 4v04 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4V01A P11362 465 765 822.0 0LI:1776 Type2 Inactive DFGout 13.648 9.683 None DFGAsp-rot-in -136.22, -176.63 -157.46, 111.62 191.59, 16.37 -99.01, 999.0 301.26, 98.54 999.0, 999.0 in-in in 7.852 Saltbr-in 2.824 HRD-in -71.33, -57.3 83.26, -24.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -104.02, 147.14 APE9-dihe-in -94.17, 112.67 APE8-dihe-out -54.82, -21.48 APE8-rot-na 334.27 APE67-dihe-in -70.4, -11.17 -58.27, -24.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 11.727 C488A,C584S None None XRAY 2.33 0.191 0.238 A 309 273 28 0 0 8 [[478, 756]] 1.0 4v01 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4V01B P11362 461 763 822.0 0LI:1770 Type2 Inactive DFGout 13.476 9.083 None DFGAsp-rot-in -140.66, -178.05 -156.06, 123.42 194.99, 33.65 -117.89, 999.0 302.59, 94.37 999.0, 999.0 in-in in 7.916 Saltbr-in 2.807 HRD-in -63.92, -54.57 77.31, -15.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -101.11, 164.12 APE9-dihe-in -107.61, 109.54 APE8-dihe-out -56.39, -11.31 APE8-rot-na 332.13 APE67-dihe-in -66.82, -7.77 -66.39, -26.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 11.814 C488A,C584S None None XRAY 2.33 0.191 0.238 B 309 275 28 0 0 8 [[478, 756]] 1.0 4v01 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4V04A P11362 463 765 822.0 0LI:1772 Type2 Inactive DFGout 14.051 10.394 None DFGAsp-rot-in -127.25, -179.24 -145.47, 116.11 187.36, 48.8 -167.94, 35.9 26.55, 54.39 23.93, -5.2 in-in in 7.864 Saltbr-in 3.206 HRD-in -65.2, -58.04 83.28, -16.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -102.41, 155.12 APE9-dihe-in -98.09, 110.26 APE8-dihe-out -52.77, -21.99 APE8-rot-na 329.65 APE67-dihe-in -70.41, -8.08 -56.89, -24.83 APE12-dist-na 19.639 APE11-dist-na 21.02 APE10-dist-na 19.322 APE9-dist-na 11.7 C488A,C584S None None XRAY 2.12 0.188 0.228 A 309 293 10 0 0 6 [[478, 756]] 1.0 4v04 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR4 FGFR4_HUMAN 4UXQA P22455 452 750 802.0 0LI:1752 Type2 Inactive DFGout 13.289 9.688 BBAminus DFGAsp-rot-in -132.52, -175.6 -154.98, 108.32 175.58, 45.21 -101.68, -37.05 301.67, 99.59 -82.32, -172.58 in-in in 7.813 Saltbr-in 2.727 HRD-in -74.83, -56.93 88.13, -22.48 in-out-out SNCioo out-out ActLoopNT-out 15.96 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -78.09, 139.64 APE9-dihe-in -109.24, 95.28 APE8-dihe-out -52.11, -28.25 APE8-rot-na 327.58 APE67-dihe-in -73.35, -9.88 -60.02, -19.19 APE12-dist-na 12.227 APE11-dist-na 12.924 APE10-dist-na 10.113 APE9-dist-na 11.612 C477A None None XRAY 1.85 0.205 0.268 A 309 286 13 0 0 0 [[467, 745]] 1.0 4uxq Homo sapiens TYR_FGFR4_HUMAN TYR 8.4e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 4TYJA P22455 447 753 802.0 0LI:60801 Type2 Inactive DFGout 13.629 9.602 BBAminus DFGAsp-rot-in -136.8, -177.28 -149.4, 114.79 188.8, 20.21 -98.18, 9.17 298.44, 103.78 79.91, -171.4 in-in in 7.82 Saltbr-in 2.757 HRD-in -71.95, -55.51 84.74, -19.01 in-out-none SNCion out-none ActLoopNT-out 19.108 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.68 APE8-dihe-in -83.91, 64.17 APE8-rot-na 36.55 APE67-dihe-in -73.09, -8.81 -53.35, -41.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.819 None None None XRAY 2.45 0.217 0.247 A 311 275 32 0 0 15 [[467, 745]] 1.0 4tyj Homo sapiens TYR_FGFR4_HUMAN TYR 1.3e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 4QRCA P22455 454 750 802.0 0LI:802 Type2 Inactive DFGout 13.848 9.448 None DFGAsp-rot-out -128.93, 176.89 -168.87, 140.49 44.1, -25.9 58.84, 41.6 314.29, 151.03 128.95, 161.76 in-in in 7.269 Saltbr-in 2.545 HRD-in -73.23, -52.1 79.8, -10.52 in-out-out SNCioo out-out ActLoopNT-out 8.662 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -79.02, 138.09 APE9-dihe-in -108.95, 92.74 APE8-dihe-out -61.85, -18.49 APE8-rot-na 333.49 APE67-dihe-in -72.31, -7.32 -59.05, -24.57 APE12-dist-na 19.537 APE11-dist-na 21.047 APE10-dist-na 16.873 APE9-dist-na 12.017 C477A,R664E None None XRAY 1.901 0.173 0.207 A 323 297 0 0 0 0 [[467, 745]] 1.0 4qrc Homo sapiens TYR_FGFR4_HUMAN TYR 1.6e-100 341.7 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR KIT KIT_HUMAN 8S17A P10721 567 931 976.0 0LI:61001 Type2 Inactive DFGout 15.425 9.951 BBAminus DFGAsp-rot-in -145.25, 179.39 -143.98, 106.64 190.84, 54.02 -67.34, -40.16 274.67, 96.68 58.73, -115.03 in-in in 7.749 Saltbr-in 2.696 HRD-in -73.68, -54.05 81.88, -13.47 in-out-in SNCioi out-in ActLoopNT-out 16.311 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -118.0, 112.95 APE9-dihe-in -124.02, 150.83 APE8-dihe-in -80.03, 74.01 APE8-rot-na 32.18 APE67-dihe-in -67.91, -14.83 -61.86, -40.28 APE12-dist-na 16.635 APE11-dist-na 13.202 APE10-dist-na 11.515 APE9-dist-na 7.701 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.2 0.203 0.228 A 327 287 0 0 0 0 [[589, 926]] 1.0 8s17 Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8S17B P10721 578 931 976.0 0LI:61001 Type2 Inactive DFGout 15.227 9.879 BBAminus DFGAsp-rot-in -145.11, 172.96 -138.62, 103.76 193.48, 29.52 -65.65, -38.27 276.93, 92.02 61.53, -118.4 in-in in 7.652 Saltbr-in 2.743 HRD-in -69.78, -55.3 82.77, -9.47 in-out-in SNCioi out-in ActLoopNT-out 16.408 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -113.26, 116.47 APE9-dihe-in -128.18, 149.58 APE8-dihe-in -80.46, 72.63 APE8-rot-na 32.73 APE67-dihe-in -67.64, -17.39 -58.96, -38.89 APE12-dist-na 16.505 APE11-dist-na 13.309 APE10-dist-na 11.718 APE9-dist-na 7.975 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.2 0.203 0.228 B 327 276 0 0 0 0 [[589, 926]] 1.0 8s17 Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 4U0IA P10721 565 933 976.0 0LI:1001 Type2 Inactive DFGout 15.152 9.758 BBAminus DFGAsp-rot-in -145.62, -174.19 -155.03, 115.98 196.58, -2.01 -76.91, -26.31 285.47, 90.73 51.17, -116.44 in-in in 7.686 Saltbr-in 2.619 HRD-in -74.87, -53.81 79.28, -20.01 in-out-in SNCioi out-in ActLoopNT-out 16.446 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -94.86, 120.83 APE9-dihe-in -126.16, 149.12 APE8-dihe-in -78.54, 70.26 APE8-rot-na 32.2 APE67-dihe-in -61.59, -16.21 -59.65, -43.09 APE12-dist-na 17.193 APE11-dist-na 14.015 APE10-dist-na 12.164 APE9-dist-na 7.681 None None None XRAY 2.0 0.204 0.239 A 315 297 12 0 0 0 [[589, 926]] 1.0 4u0i Homo sapiens TYR_KIT_HUMAN TYR 3.9e-102 347.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR ROR1 ROR1_HUMAN 6TU9A Q01973 460 749 937.0 0LI:801 Type1 Pseudo None 999.0 999.0 None DFGAsp-rot-in -143.45, 175.76 -148.29, 81.04 193.55, 11.09 -104.43, 119.64 999.0, 999.0 -53.65, -7.79 in-in in 8.227 Saltbr-in 2.725 HRD-in -69.35, -57.72 81.6, -11.35 in-out-in SNCioi out-in ActLoopNT-out 15.395 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -88.59, 129.49 APE9-dihe-in -125.15, 133.19 APE8-dihe-in -78.4, 68.8 APE8-rot-na 36.93 APE67-dihe-in -68.17, -18.18 -55.42, -35.07 APE12-dist-na 999.0 APE11-dist-na 15.69 APE10-dist-na 11.605 APE9-dist-na 6.992 None None None XRAY 1.94 0.21 0.241 A 306 268 22 0 0 4 [[473, 748]] 1.0 6tu9 Homo sapiens TYR_ROR1_HUMAN TYR 1.2e-94 322.4 2 260 259 632 633 634 636 638 506 523 527 612 614 613 615 674 662 657 656 655 654 653 652 651 553 Inactive tyrosine-protein kinase transmembrane receptor ROR1
TYR ROR1 ROR1_HUMAN 6TU9B Q01973 465 750 937.0 0LI:801 Type1 Pseudo None 999.0 999.0 None DFGAsp-rot-in -143.03, 176.7 -144.7, 81.77 189.61, 21.61 -85.65, -31.03 999.0, 999.0 92.49, -44.82 in-in in 8.283 Saltbr-in 2.974 HRD-in -64.86, -61.91 82.91, -9.99 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -100.96, 129.63 APE9-dihe-in -119.15, 127.45 APE8-dihe-in -76.72, 68.52 APE8-rot-na 33.66 APE67-dihe-in -67.05, -20.69 -57.04, -32.64 APE12-dist-na 17.025 APE11-dist-na 15.144 APE10-dist-na 11.197 APE9-dist-na 6.97 None None None XRAY 1.94 0.21 0.241 B 306 261 25 0 0 2 [[473, 748]] 1.0 6tu9 Homo sapiens TYR_ROR1_HUMAN TYR 1.2e-94 322.4 2 260 259 632 633 634 636 638 506 523 527 612 614 613 615 674 662 657 656 655 654 653 652 651 553 Inactive tyrosine-protein kinase transmembrane receptor ROR1
TYR SRC SRC_HUMAN 7OTEA P12931 261 536 536.0 0LI:601 Type2 Inactive DFGout 13.678 9.025 BBAminus DFGAsp-rot-in -119.79, 176.26 -136.22, 145.66 213.09, 14.46 -117.56, 59.41 289.7, 90.17 173.51, 999.0 in-in in 7.879 Saltbr-in 2.532 HRD-in -78.56, -49.16 85.49, -24.96 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 150.65 APE8-dihe-in -61.46, 92.79 APE8-rot-na 30.48 APE67-dihe-in -70.25, -17.48 -54.65, -43.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.618 None None None XRAY 2.49 0.179 0.252 A 293 259 17 0 0 17 [[270, 521]] 1.0 7ote Homo sapiens TYR_SRC_HUMAN TYR 1.8e-94 321.9 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 7OTEB P12931 261 536 536.0 0LI:601 Type2 Inactive DFGout 14.508 9.181 BBAminus DFGAsp-rot-in -149.51, 179.45 -147.71, 103.83 202.03, -42.09 -80.1, -7.38 295.65, 135.68 68.38, 999.0 in-out in 8.912 Saltbr-out 4.135 HRD-in -81.29, -57.98 98.12, -42.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.79 APE8-dihe-in -102.78, 62.88 APE8-rot-na 39.14 APE67-dihe-in -65.77, -18.22 -41.35, -46.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 9.298 None None None XRAY 2.49 0.179 0.252 B 293 259 17 0 0 17 [[270, 521]] 1.0 7ote Homo sapiens TYR_SRC_HUMAN TYR 1.8e-94 321.9 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR ABL1 ABL1_MOUSE 3IK3A P00520 229 513 1123.0 0LI:60001 Type2 Inactive DFGout 13.504 9.438 BBAminus DFGAsp-rot-in -139.29, -179.88 -153.49, 108.65 178.83, 14.87 -85.72, -9.94 290.6, 95.91 72.02, 48.56 in-in in 7.934 Saltbr-in 2.538 HRD-in -70.15, -60.9 90.87, -12.1 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -111.42, 120.77 APE9-dihe-in -114.74, 139.96 APE8-dihe-in -82.31, 89.85 APE8-rot-na 32.91 APE67-dihe-in -77.22, -7.68 -48.36, -44.8 APE12-dist-na 16.01 APE11-dist-na 11.84 APE10-dist-na 8.456 APE9-dist-na 7.993 T315I None None XRAY 1.9 0.216 0.258 A 288 279 6 0 0 6 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.7e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3IK3B P00520 229 513 1123.0 0LI:60002 Type2 Inactive DFGout 13.498 9.17 BBAminus DFGAsp-rot-in -129.46, 178.53 -148.47, 114.27 179.12, 15.0 -91.94, -7.12 286.37, 101.01 64.82, 50.27 in-in in 7.992 Saltbr-in 2.655 HRD-in -76.51, -54.44 85.69, -10.99 in-out-in SNCioi out-in ActLoopNT-out 15.703 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -129.88, 123.97 APE9-dihe-in -117.43, 141.07 APE8-dihe-in -76.99, 85.79 APE8-rot-na 29.46 APE67-dihe-in -85.08, -5.45 -41.61, -41.71 APE12-dist-na 15.826 APE11-dist-na 11.596 APE10-dist-na 8.603 APE9-dist-na 7.851 T315I None None XRAY 1.9 0.216 0.258 B 288 285 0 0 0 0 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.7e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3OXZA P00520 229 511 1123.0 0LI:60001 Type2 Inactive DFGout 13.316 8.94 BBAminus DFGAsp-rot-in -130.11, -171.24 -154.37, 127.79 190.9, -5.05 -115.42, 5.71 286.77, 98.95 48.45, 62.42 in-in in 8.004 Saltbr-in 3.005 HRD-in -71.2, -52.05 81.82, -16.86 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -90.47, 133.09 APE9-dihe-in -119.78, 140.42 APE8-dihe-in -76.32, 77.74 APE8-rot-na 32.13 APE67-dihe-in -76.96, -8.32 -43.1, -46.11 APE12-dist-na 15.377 APE11-dist-na 10.76 APE10-dist-na 8.339 APE9-dist-na 8.088 None None None XRAY 2.2 0.218 0.261 A 284 267 16 0 0 10 [[242, 495]] 1.0 3oxz Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1

Ligand: LI

Total number of chains: 5
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 5 100.0% 3IK3B
All chains
Pymol session (all) Pymol script (all)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 7WF5A P00523 257 533 533.0 0LI:601 Type2 Inactive DFGout 13.293 8.853 BBAminus DFGAsp-rot-in -138.86, 178.47 -148.72, 117.06 191.24, -2.56 -103.55, 7.74 290.87, 100.32 61.55, 53.93 in-in in 7.671 Saltbr-in 2.617 HRD-in -81.35, -59.57 92.68, -15.97 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.23 APE8-dihe-in -80.1, 61.84 APE8-rot-na 34.61 APE67-dihe-in -62.67, -20.24 -53.79, -38.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 9.003 None None None XRAY 1.798 0.163 0.183 A 286 261 16 0 0 16 [[267, 518]] 1.0 7wf5 Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 7WF5B P00523 254 533 533.0 0LI:601 Type2 Inactive DFGout 13.337 8.808 BBAminus DFGAsp-rot-in -139.72, 178.97 -149.88, 114.3 190.37, -1.99 -104.08, 8.92 292.96, 104.73 64.81, 53.74 in-in in 7.856 Saltbr-in 2.792 HRD-in -81.76, -58.24 93.94, -19.23 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.23 APE8-dihe-in -81.79, 58.44 APE8-rot-na 33.89 APE67-dihe-in -61.6, -25.83 -54.2, -35.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 9.562 None None None XRAY 1.798 0.163 0.183 B 286 265 15 0 0 15 [[267, 518]] 1.0 7wf5 Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR ABL1 ABL1_MOUSE 3IK3A P00520 229 513 1123.0 0LI:60001 Type2 Inactive DFGout 13.504 9.438 BBAminus DFGAsp-rot-in -139.29, -179.88 -153.49, 108.65 178.83, 14.87 -85.72, -9.94 290.6, 95.91 72.02, 48.56 in-in in 7.934 Saltbr-in 2.538 HRD-in -70.15, -60.9 90.87, -12.1 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -111.42, 120.77 APE9-dihe-in -114.74, 139.96 APE8-dihe-in -82.31, 89.85 APE8-rot-na 32.91 APE67-dihe-in -77.22, -7.68 -48.36, -44.8 APE12-dist-na 16.01 APE11-dist-na 11.84 APE10-dist-na 8.456 APE9-dist-na 7.993 T315I None None XRAY 1.9 0.216 0.258 A 288 279 6 0 0 6 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.7e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3IK3B P00520 229 513 1123.0 0LI:60002 Type2 Inactive DFGout 13.498 9.17 BBAminus DFGAsp-rot-in -129.46, 178.53 -148.47, 114.27 179.12, 15.0 -91.94, -7.12 286.37, 101.01 64.82, 50.27 in-in in 7.992 Saltbr-in 2.655 HRD-in -76.51, -54.44 85.69, -10.99 in-out-in SNCioi out-in ActLoopNT-out 15.703 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -129.88, 123.97 APE9-dihe-in -117.43, 141.07 APE8-dihe-in -76.99, 85.79 APE8-rot-na 29.46 APE67-dihe-in -85.08, -5.45 -41.61, -41.71 APE12-dist-na 15.826 APE11-dist-na 11.596 APE10-dist-na 8.603 APE9-dist-na 7.851 T315I None None XRAY 1.9 0.216 0.258 B 288 285 0 0 0 0 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.7e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3OXZA P00520 229 511 1123.0 0LI:60001 Type2 Inactive DFGout 13.316 8.94 BBAminus DFGAsp-rot-in -130.11, -171.24 -154.37, 127.79 190.9, -5.05 -115.42, 5.71 286.77, 98.95 48.45, 62.42 in-in in 8.004 Saltbr-in 3.005 HRD-in -71.2, -52.05 81.82, -16.86 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -90.47, 133.09 APE9-dihe-in -119.78, 140.42 APE8-dihe-in -76.32, 77.74 APE8-rot-na 32.13 APE67-dihe-in -76.96, -8.32 -43.1, -46.11 APE12-dist-na 15.377 APE11-dist-na 10.76 APE10-dist-na 8.339 APE9-dist-na 8.088 None None None XRAY 2.2 0.218 0.261 A 284 267 16 0 0 10 [[242, 495]] 1.0 3oxz Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1