Ligand: H52

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 3D9VA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC ROCK1 ROCK1_HUMAN 3D9VA 3.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H52 Type1 6 - 405 0 None None Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3D9VB 3.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_iioo H52 Type1 6 - 402 0 None None Rho-associated protein kinase 1

Ligand: H52

Total number of chains: 7
Active chains: 3
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 71.4% 1Q8UA
DFGin ABAminus 2 28.6% 5M6VA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC PRKACA KAPCA_BOVIN 2GNHA 2.05 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H52, H52 Type1, Allosteric 11 - 351 0 SEP11,TPO198,SEP339 L50I,V124M,E128D,Q182K,T184A cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 2GNLA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H52 Type1 12 - 351 0 TPO198,SEP339 L50I,Q182K,T184A cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 1Q8UA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H52, H52 Type1, Allosteric 8 - 351 0 SEP11,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_CRIGR 5M6VA 1.418 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H52 Type1 1 - 351 0 SEP11,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
TKL ROCO4 ROCO4_DICDI 4F1TA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_iioo H52, H52 Type1, Allosteric 1019 - 1292 0 None None Probable serine/threonine-protein kinase roco4 Dictyostelium discoideum
AGC ROCK1 ROCK1_HUMAN 3D9VA 3.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H52 Type1 6 - 405 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 3D9VB 3.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_iioo H52 Type1 6 - 402 0 None None Rho-associated protein kinase 1 Homo sapiens

Ligand: H52

Total number of chains: 5
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 60.0% 1Q8UA
DFGin ABAminus 2 40.0% 5M6VA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC PRKACA KAPCA_BOVIN 2GNHA 2.05 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H52, H52 Type1, Allosteric 11 - 351 0 SEP11,TPO198,SEP339 L50I,V124M,E128D,Q182K,T184A cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 2GNLA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H52 Type1 12 - 351 0 TPO198,SEP339 L50I,Q182K,T184A cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 1Q8UA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H52, H52 Type1, Allosteric 8 - 351 0 SEP11,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_CRIGR 5M6VA 1.418 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H52 Type1 1 - 351 0 SEP11,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
TKL ROCO4 ROCO4_DICDI 4F1TA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_iioo H52, H52 Type1, Allosteric 1019 - 1292 0 None None Probable serine/threonine-protein kinase roco4 Dictyostelium discoideum