KinCore

Ligand: FMM (Lapatinib)

Total number of chains: 3

Spatial label	Dihedral label	Number of Chains	Representative
DFGin	BLBplus	3	1XKKA

Database table as tsv

Family	Gene	UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein
TYR	EGFR	EGFR_HUMAN	1XKKA	2.4	Inactive	DFGin‑BLBplus	out-out	out-out	FMM	Type1.5_Back	702 - 1018	8	None	None	Epidermal growth factor receptor
TYR	ERBB4	ERBB4_HUMAN	3BBTB	2.8	Inactive	DFGin‑BLBplus	out-out	out-none	FMM	Type1.5_Back	708 - 998	14	None	None	Receptor tyrosine-protein kinase erbB-4
TYR	ERBB4	ERBB4_HUMAN	3BBTD	2.8	Inactive	DFGin‑BLBplus	out-out	out-none	FMM	Type1.5_Back	709 - 988	16	None	None	Receptor tyrosine-protein kinase erbB-4

Ligand: FMM (Lapatinib)

Total number of chains: 3

Spatial label	Dihedral label	Number of Chains	Representative
DFGin	BLBplus	3	1XKKA

Database table as tsv

Family	Gene	UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism
TYR	EGFR	EGFR_HUMAN	1XKKA	2.4	Inactive	DFGin‑BLBplus	out-out	out-out	FMM	Type1.5_Back	702 - 1018	8	None	None	Epidermal growth factor receptor	Homo sapiens
TYR	ERBB4	ERBB4_HUMAN	3BBTB	2.8	Inactive	DFGin‑BLBplus	out-out	out-none	FMM	Type1.5_Back	708 - 998	14	None	None	Receptor tyrosine-protein kinase erbB-4	Homo sapiens
TYR	ERBB4	ERBB4_HUMAN	3BBTD	2.8	Inactive	DFGin‑BLBplus	out-out	out-none	FMM	Type1.5_Back	709 - 988	16	None	None	Receptor tyrosine-protein kinase erbB-4	Homo sapiens

Ligand: FMM (Lapatinib)

Total number of chains: 0

Spatial label	Dihedral label	Number of Chains	Representative

Database table as tsv

Family	Gene	UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism