Ligand: FMM (Lapatinib, Tykerb)

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 3 100.0% 1XKKA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 1XKKA P00533 702 1018 1210.0 FMM:91 Type1.5_Back Inactive DFGin 4.633 13.862 BLBplus -142.44, -178.32 66.71, 16.01 -82.53, 163.31 49.94, 92.67 85.22, -36.9 out-out out 13.318 Saltbr-out 13.504 HRD-in -57.62, -56.43 78.67, -6.78 out-out-out SNCooo out-out ActLoopNT-out 6.262 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.63 APE8-dihe-out -68.36, 44.76 APE8-rot-na 338.83 APE67-dihe-in -77.24, -6.92 -41.16, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.332 None None None XRAY 2.4 0.209 0.255 A 352 289 16 0 0 8 [[712, 970]] 1.0 1xkk TYR_EGFR_HUMAN TYR 1.3e-87 299.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR ERBB4 ERBB4_HUMAN 3BBTB Q15303 708 998 1308.0 FMM:60091 Type1.5_Back Inactive DFGin 5.388 13.29 BLBplus -127.16, 173.3 66.25, 23.71 -69.76, 136.77 43.82, 86.88 52.5, 43.04 out-out out 14.04 Saltbr-out 15.322 HRD-in -81.46, -41.77 86.97, -19.99 out-out-none SNCoon out-none ActLoopNT-out 6.96 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 41.83 APE8-rot-na 22.98 APE67-dihe-in -74.99, -6.22 -53.46, -44.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.253 0.289 B 328 274 16 0 0 14 [[718, 976]] 1.0 3bbt TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2 259 258 860 861 862 864 866 751 768 772 840 842 841 843 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
TYR ERBB4 ERBB4_HUMAN 3BBTD Q15303 709 988 1308.0 FMM:60091 Type1.5_Back Inactive DFGin 5.788 13.639 BLBplus -120.15, 168.79 64.17, 29.05 -72.9, 132.71 41.75, 86.79 49.44, 51.55 out-out out 14.408 Saltbr-out 15.84 HRD-in -78.17, -59.42 94.63, -3.9 out-out-none SNCoon out-none ActLoopNT-out 7.615 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 43.72 APE8-rot-na 29.87 APE67-dihe-in -73.55, -7.87 -60.37, -33.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.253 0.289 D 328 259 21 0 0 16 [[718, 976]] 1.0 3bbt TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2 259 258 860 861 862 864 866 751 768 772 840 842 841 843 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4

Ligand: FMM (Lapatinib, Tykerb)

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 3 100.0% 1XKKA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 1XKKA P00533 702 1018 1210.0 FMM:91 Type1.5_Back Inactive DFGin 4.633 13.862 BLBplus -142.44, -178.32 66.71, 16.01 -82.53, 163.31 49.94, 92.67 85.22, -36.9 out-out out 13.318 Saltbr-out 13.504 HRD-in -57.62, -56.43 78.67, -6.78 out-out-out SNCooo out-out ActLoopNT-out 6.262 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.63 APE8-dihe-out -68.36, 44.76 APE8-rot-na 338.83 APE67-dihe-in -77.24, -6.92 -41.16, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.332 None None None XRAY 2.4 0.209 0.255 A 352 289 16 0 0 8 [[712, 970]] 1.0 1xkk Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR ERBB4 ERBB4_HUMAN 3BBTB Q15303 708 998 1308.0 FMM:60091 Type1.5_Back Inactive DFGin 5.388 13.29 BLBplus -127.16, 173.3 66.25, 23.71 -69.76, 136.77 43.82, 86.88 52.5, 43.04 out-out out 14.04 Saltbr-out 15.322 HRD-in -81.46, -41.77 86.97, -19.99 out-out-none SNCoon out-none ActLoopNT-out 6.96 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 41.83 APE8-rot-na 22.98 APE67-dihe-in -74.99, -6.22 -53.46, -44.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.253 0.289 B 328 274 16 0 0 14 [[718, 976]] 1.0 3bbt Homo sapiens TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2 259 258 860 861 862 864 866 751 768 772 840 842 841 843 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
TYR ERBB4 ERBB4_HUMAN 3BBTD Q15303 709 988 1308.0 FMM:60091 Type1.5_Back Inactive DFGin 5.788 13.639 BLBplus -120.15, 168.79 64.17, 29.05 -72.9, 132.71 41.75, 86.79 49.44, 51.55 out-out out 14.408 Saltbr-out 15.84 HRD-in -78.17, -59.42 94.63, -3.9 out-out-none SNCoon out-none ActLoopNT-out 7.615 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 43.72 APE8-rot-na 29.87 APE67-dihe-in -73.55, -7.87 -60.37, -33.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.253 0.289 D 328 259 21 0 0 16 [[718, 976]] 1.0 3bbt Homo sapiens TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2 259 258 860 861 862 864 866 751 768 772 840 842 841 843 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4

Ligand: FMM (Lapatinib, Tykerb)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name