Ligand: D15

Total number of chains: 9
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 9 2VX3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC CDKL1 CDKL1_HUMAN 4AGU 2.4 None DFGin‑BLAminus in-in in-none D15 Type1 2 - 291 12 None T159D,Y161E Cyclin-dependent kinase-like 1
CMGC CDKL1 CDKL1_HUMAN 4AGU 2.4 None DFGin‑BLAminus in-in in-none D15 Type1 3 - 292 12 None T159D,Y161E Cyclin-dependent kinase-like 1
CMGC CDKL1 CDKL1_HUMAN 4AGU 2.4 None DFGin‑BLAminus in-in in-none D15 Type1 2 - 291 12 None T159D,Y161E Cyclin-dependent kinase-like 1
CMGC DYRK1A DYR1A_HUMAN 2VX3 2.4 Active DFGin‑BLAminus in-in in-in D15 Type1 135 - 481 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 2VX3 2.4 Active DFGin‑BLAminus in-in in-in D15 Type1 135 - 480 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 2VX3 2.4 Active DFGin‑BLAminus in-in in-in D15 Type1 135 - 480 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 2VX3 2.4 Active DFGin‑BLAminus in-in in-in D15 Type1 135 - 480 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 2WO6 2.5 Active DFGin‑BLAminus in-in in-in D15 Type1 133 - 481 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 2WO6 2.5 Active DFGin‑BLAminus in-in in-in D15 Type1 136 - 480 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: D15

Total number of chains: 9
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 9 2VX3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CDKL1 CDKL1_HUMAN 4AGU 2.4 None DFGin‑BLAminus in-in in-none D15 Type1 2 - 291 12 None T159D,Y161E Cyclin-dependent kinase-like 1 Homo sapiens
CMGC CDKL1 CDKL1_HUMAN 4AGU 2.4 None DFGin‑BLAminus in-in in-none D15 Type1 3 - 292 12 None T159D,Y161E Cyclin-dependent kinase-like 1 Homo sapiens
CMGC CDKL1 CDKL1_HUMAN 4AGU 2.4 None DFGin‑BLAminus in-in in-none D15 Type1 2 - 291 12 None T159D,Y161E Cyclin-dependent kinase-like 1 Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 2VX3 2.4 Active DFGin‑BLAminus in-in in-in D15 Type1 135 - 481 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 2VX3 2.4 Active DFGin‑BLAminus in-in in-in D15 Type1 135 - 480 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 2VX3 2.4 Active DFGin‑BLAminus in-in in-in D15 Type1 135 - 480 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 2VX3 2.4 Active DFGin‑BLAminus in-in in-in D15 Type1 135 - 480 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 2WO6 2.5 Active DFGin‑BLAminus in-in in-in D15 Type1 133 - 481 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 2WO6 2.5 Active DFGin‑BLAminus in-in in-in D15 Type1 136 - 480 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens

Ligand: D15

Total number of chains: 0
Spatial label Dihedral label Number of Chains Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism