Ligand: BYZ

Total number of chains: 5
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 80.0% 5S7ZB
None None 1 20.0% 6Q3CA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 9ETPC P24941 1 296 298.0 BYZ:60501,BYZ:60502,BYZ:60503 Type1,Allosteric,Allosteric Active DFGin 6.5626 15.0258 BLAminus -139.85, -178.12 50.6, 80.08 -91.54, 27.1 284.21, 67.12 -60.57, -29.59 in-in in 8.5968 Saltbr-in 2.9557 HRD-in -84.41, -56.87 79.21, 8.08 in-in-in SNCiii in-in ActLoopNT-in 2.8209 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.1, 146.93 APE9-dihe-na 73.24, 128.07 APE8-dihe-in -58.4, 133.61 APE8-rot-in 297.06 APE67-dihe-in -57.21, -23.28 -33.45, -54.48 APE12-dist-in 12.7593 APE11-dist-in 9.6652 APE10-dist-in 6.8156 APE9-dist-in 3.3599 None TPO160 TPO160 XRAY 2.48 0.202 0.231 C 302.0 279.0 17 28 28 0 [[4, 286]] 1.0 9etp CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ETPA P24941 1 297 298.0 BYZ:60601,BYZ:60603,BYZ:60604,BYZ:60605,BYZ:60606,BYZ:60607 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Active DFGin 6.8397 15.4944 BLAminus -127.49, -178.48 53.77, 85.13 -106.7, 35.09 276.24, 76.74 -80.48, -25.81 in-in in 8.5464 Saltbr-in 3.0455 HRD-in -77.4, -56.67 72.11, 14.41 in-in-in SNCiii in-in ActLoopNT-in 2.9499 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.24, 146.07 APE9-dihe-na 79.12, 126.78 APE8-dihe-in -56.13, 139.51 APE8-rot-in 303.8 APE67-dihe-in -55.08, -20.41 -52.32, -47.85 APE12-dist-in 12.5873 APE11-dist-in 9.7655 APE10-dist-in 6.8768 APE9-dist-in 3.2852 None TPO160 TPO160 XRAY 2.48 0.202 0.231 A 302.0 294.0 3 28 28 0 [[4, 286]] 1.0 9etp CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 6Q3CA P24941 2 298 298.0 BYZ:301,BYZ:302 Type1,Type1 Inactive None 11.0115 18.3445 None -105.89, 149.7 74.24, 21.25 -56.86, 140.5 243.36, 93.53 83.71, -11.42 out-out out 15.4643 Saltbr-out 16.5166 HRD-in -92.99, -59.73 78.01, -9.32 out-out-out SNCooo out-out ActLoopNT-out 5.764 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.04, 126.39 APE9-dihe-na -72.41, 128.47 APE8-dihe-in -64.49, 140.67 APE8-rot-out 189.27 APE67-dihe-in -62.38, -27.04 -100.06, -1.63 APE12-dist-out 20.2463 APE11-dist-out 17.5302 APE10-dist-out 18.8633 APE9-dist-out 10.3805 None None OCS177 XRAY 1.29 0.142 0.178 A 306.0 289.0 8 28 28 0 [[4, 286]] 1.0 6q3c CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
TKL ACVR1 ACVR1_HUMAN 5S7ZB Q04771 205 499 509.0 LU8:501,BYZ:505 Type1,Allosteric Inactive DFGin 6.9632 13.3741 BLAminus -125.8, 161.65 77.14, 88.32 -102.44, 23.35 302.89, 177.91 -73.03, -13.12 in-out in 8.7708 Saltbr-out 4.7211 HRD-in -76.79, -54.43 80.82, -3.64 out-in-out SNCoio in-out ActLoopNT-in 2.9201 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.61, 165.38 APE9-dihe-na -60.57, 163.68 APE8-dihe-in -58.84, 127.79 APE8-rot-in 300.37 APE67-dihe-in -58.11, -27.66 -62.19, -41.34 APE12-dist-in 10.3506 APE11-dist-out 6.1474 APE10-dist-out 9.0017 APE9-dist-in 3.8366 Q207D None None XRAY 1.3 0.163 0.184 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7z TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7ZA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,BYZ:510,BYZ:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3715 13.3787 BLAminus -118.29, 164.94 73.01, 90.28 -101.45, 25.18 297.95, 179.49 -66.08, -18.47 in-out in 9.0354 Saltbr-out 5.8164 HRD-in -75.5, -56.61 78.44, 1.56 out-in-out SNCoio in-out ActLoopNT-in 2.884 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.97, 169.25 APE9-dihe-na -61.57, 164.92 APE8-dihe-in -63.28, 125.7 APE8-rot-in 303.7 APE67-dihe-in -57.35, -34.69 -61.46, -39.19 APE12-dist-in 10.5839 APE11-dist-out 6.2834 APE10-dist-out 8.9041 APE9-dist-in 3.732 Q207D None None XRAY 1.3 0.163 0.184 A 301.0 287.0 11 32 23 9 [[207, 497]] 1.0 5s7z TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1

Ligand: BYZ

Total number of chains: 5
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 80.0% 5S7ZB
None None 1 20.0% 6Q3CA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 9ETPC P24941 1 296 298.0 BYZ:60501,BYZ:60502,BYZ:60503 Type1,Allosteric,Allosteric Active DFGin 6.5626 15.0258 BLAminus -139.85, -178.12 50.6, 80.08 -91.54, 27.1 284.21, 67.12 -60.57, -29.59 in-in in 8.5968 Saltbr-in 2.9557 HRD-in -84.41, -56.87 79.21, 8.08 in-in-in SNCiii in-in ActLoopNT-in 2.8209 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.1, 146.93 APE9-dihe-na 73.24, 128.07 APE8-dihe-in -58.4, 133.61 APE8-rot-in 297.06 APE67-dihe-in -57.21, -23.28 -33.45, -54.48 APE12-dist-in 12.7593 APE11-dist-in 9.6652 APE10-dist-in 6.8156 APE9-dist-in 3.3599 None TPO160 TPO160 XRAY 2.48 0.202 0.231 C 302.0 279.0 17 28 28 0 [[4, 286]] 1.0 9etp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ETPA P24941 1 297 298.0 BYZ:60601,BYZ:60603,BYZ:60604,BYZ:60605,BYZ:60606,BYZ:60607 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Active DFGin 6.8397 15.4944 BLAminus -127.49, -178.48 53.77, 85.13 -106.7, 35.09 276.24, 76.74 -80.48, -25.81 in-in in 8.5464 Saltbr-in 3.0455 HRD-in -77.4, -56.67 72.11, 14.41 in-in-in SNCiii in-in ActLoopNT-in 2.9499 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.24, 146.07 APE9-dihe-na 79.12, 126.78 APE8-dihe-in -56.13, 139.51 APE8-rot-in 303.8 APE67-dihe-in -55.08, -20.41 -52.32, -47.85 APE12-dist-in 12.5873 APE11-dist-in 9.7655 APE10-dist-in 6.8768 APE9-dist-in 3.2852 None TPO160 TPO160 XRAY 2.48 0.202 0.231 A 302.0 294.0 3 28 28 0 [[4, 286]] 1.0 9etp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 6Q3CA P24941 2 298 298.0 BYZ:301,BYZ:302 Type1,Type1 Inactive None 11.0115 18.3445 None -105.89, 149.7 74.24, 21.25 -56.86, 140.5 243.36, 93.53 83.71, -11.42 out-out out 15.4643 Saltbr-out 16.5166 HRD-in -92.99, -59.73 78.01, -9.32 out-out-out SNCooo out-out ActLoopNT-out 5.764 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.04, 126.39 APE9-dihe-na -72.41, 128.47 APE8-dihe-in -64.49, 140.67 APE8-rot-out 189.27 APE67-dihe-in -62.38, -27.04 -100.06, -1.63 APE12-dist-out 20.2463 APE11-dist-out 17.5302 APE10-dist-out 18.8633 APE9-dist-out 10.3805 None None OCS177 XRAY 1.29 0.142 0.178 A 306.0 289.0 8 28 28 0 [[4, 286]] 1.0 6q3c Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
TKL ACVR1 ACVR1_HUMAN 5S7ZB Q04771 205 499 509.0 LU8:501,BYZ:505 Type1,Allosteric Inactive DFGin 6.9632 13.3741 BLAminus -125.8, 161.65 77.14, 88.32 -102.44, 23.35 302.89, 177.91 -73.03, -13.12 in-out in 8.7708 Saltbr-out 4.7211 HRD-in -76.79, -54.43 80.82, -3.64 out-in-out SNCoio in-out ActLoopNT-in 2.9201 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.61, 165.38 APE9-dihe-na -60.57, 163.68 APE8-dihe-in -58.84, 127.79 APE8-rot-in 300.37 APE67-dihe-in -58.11, -27.66 -62.19, -41.34 APE12-dist-in 10.3506 APE11-dist-out 6.1474 APE10-dist-out 9.0017 APE9-dist-in 3.8366 Q207D None None XRAY 1.3 0.163 0.184 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7z Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7ZA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,BYZ:510,BYZ:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3715 13.3787 BLAminus -118.29, 164.94 73.01, 90.28 -101.45, 25.18 297.95, 179.49 -66.08, -18.47 in-out in 9.0354 Saltbr-out 5.8164 HRD-in -75.5, -56.61 78.44, 1.56 out-in-out SNCoio in-out ActLoopNT-in 2.884 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.97, 169.25 APE9-dihe-na -61.57, 164.92 APE8-dihe-in -63.28, 125.7 APE8-rot-in 303.7 APE67-dihe-in -57.35, -34.69 -61.46, -39.19 APE12-dist-in 10.5839 APE11-dist-out 6.2834 APE10-dist-out 8.9041 APE9-dist-in 3.732 Q207D None None XRAY 1.3 0.163 0.184 A 301.0 287.0 11 32 23 9 [[207, 497]] 1.0 5s7z Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1

Ligand: BYZ

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name