Ligand: BX7

Total number of chains: 11
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 72.7% 4EUUA
DFGin BLBplus 2 18.2% 4IM2A
DFGin None 1 9.1% 4IWPA
All chains
Pymol session (all) Pymol script (all)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
OTHER TBK1 TBK1_HUMAN 4EUUA Q9UHD2 2 307 729.0 BX7:60401 Type1 Active DFGin 6.885 13.708 BLAminus DFGAsp-rot-in -149.45, -171.7 60.73, 75.15 188.74, -1.16 -94.29, 22.12 284.45, 84.57 -56.95, -31.59 in-in in 8.35 Saltbr-in 2.777 HRD-in -89.96, -55.24 75.16, 8.62 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.22, 171.79 APE9-dihe-na 116.46, -167.3 APE8-dihe-in -133.65, 129.66 APE8-rot-in 296.24 APE67-dihe-in -70.89, -19.14 -44.3, -46.34 APE12-dist-in 9.025 APE11-dist-in 10.184 APE10-dist-in 4.841 APE9-dist-in 3.409 D135N SEP172 SEP172 XRAY 1.8 0.17 0.194 A 319 306 0 0 0 0 [[9, 625]] 1.0 4euu OTHER_TBK1_HUMAN OTHER 5.3e-42 150.0 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4EUUB Q9UHD2 2 307 729.0 BX7:60401 Type1 Active DFGin 6.854 13.557 BLAminus DFGAsp-rot-in -149.67, -169.25 59.25, 76.47 186.8, 3.98 -95.25, 24.67 286.86, 82.81 -60.26, -24.9 in-in in 8.312 Saltbr-in 2.823 HRD-in -94.27, -51.86 75.28, 11.95 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.26, 163.87 APE9-dihe-na 122.52, -168.66 APE8-dihe-in -132.25, 128.66 APE8-rot-in 296.78 APE67-dihe-in -66.29, -20.21 -52.98, -41.57 APE12-dist-in 9.095 APE11-dist-in 10.127 APE10-dist-in 4.813 APE9-dist-in 3.422 D135N SEP172 SEP172 XRAY 1.8 0.17 0.194 B 319 306 0 0 0 0 [[9, 625]] 1.0 4euu OTHER_TBK1_HUMAN OTHER 5.3e-42 150.0 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4EUTA Q9UHD2 2 385 729.0 BX7:60401 Type1 Inactive DFGin 6.883 13.639 BLAminus DFGAsp-rot-in -159.22, -168.26 61.75, 57.03 188.04, 0.46 -82.72, 42.54 295.65, 82.26 -64.31, -31.5 in-in in 8.316 Saltbr-in 2.321 HRD-in -73.96, -54.83 84.2, -10.29 in-in-out SNCiio in-out ActLoopNT-in 3.012 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.7, 129.45 APE9-dihe-na -58.48, -57.42 APE8-dihe-in -136.66, 145.1 APE8-rot-out 88.82 APE67-dihe-in -52.88, -19.91 -92.7, -13.2 APE12-dist-out 30.135 APE11-dist-out 24.099 APE10-dist-out 26.516 APE9-dist-out 32.471 D135N None None XRAY 2.6 0.216 0.257 A 396 382 2 0 0 0 [[9, 625]] 1.0 4eut OTHER_TBK1_HUMAN OTHER 9.1e-42 149.5 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4EUTB Q9UHD2 2 385 729.0 BX7:60401 Type1 Inactive DFGin 6.879 13.663 BLAminus DFGAsp-rot-in -146.55, -168.94 58.32, 68.8 182.88, 2.89 -93.86, 31.15 285.43, 84.48 -61.33, -33.63 in-in in 8.4 Saltbr-in 2.622 HRD-in -76.77, -55.1 80.6, -8.11 in-in-out SNCiio in-out ActLoopNT-in 2.984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -97.14, 115.67 APE9-dihe-na -68.94, -54.62 APE8-dihe-in -115.7, 141.18 APE8-rot-out 64.24 APE67-dihe-in -58.71, -19.7 -101.7, -8.42 APE12-dist-out 27.656 APE11-dist-out 24.127 APE10-dist-out 27.128 APE9-dist-out 33.299 D135N None None XRAY 2.6 0.216 0.257 B 396 377 7 0 0 0 [[9, 625]] 1.0 4eut OTHER_TBK1_HUMAN OTHER 9.1e-42 149.5 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IW0A Q9UHD2 2 657 729.0 BX7:60701 Type1 Active DFGin 7.242 13.902 BLAminus DFGAsp-rot-in -155.36, -171.41 57.26, 68.28 187.09, 20.13 -92.34, 33.21 293.18, 94.33 -70.66, -23.63 in-in in 9.43 Saltbr-in 2.462 HRD-in -106.67, -50.47 63.21, 19.01 in-in-in SNCiii in-in ActLoopNT-in 3.397 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.9, 153.67 APE9-dihe-na 126.79, 169.6 APE8-dihe-in -88.95, 160.27 APE8-rot-in 323.58 APE67-dihe-in -68.26, -28.77 -61.06, -59.04 APE12-dist-in 9.098 APE11-dist-in 9.878 APE10-dist-in 4.64 APE9-dist-in 3.211 D135N SEP172 SEP172 XRAY 4.0 0.24 0.291 A 658 646 0 0 0 0 [[9, 625]] 1.0 4iw0 OTHER_TBK1_HUMAN OTHER 1.7e-41 148.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6O8BA Q9UHD2 2 656 729.0 BX7:60701 Type1 Inactive DFGin 8.024 14.156 BLAminus DFGAsp-rot-in -167.16, -174.99 52.37, 56.07 185.52, 18.9 -72.25, 60.65 314.15, 135.49 -69.84, -26.09 out-out out 13.196 Saltbr-out 9.426 HRD-in -76.99, -64.92 59.52, 19.15 out-in-out SNCoio in-out ActLoopNT-in 3.414 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiii APE10-dihe-na -154.01, 141.29 APE9-dihe-na 147.45, -177.44 APE8-dihe-in -109.41, 155.1 APE8-rot-out 222.95 APE67-dihe-in -65.05, -44.47 -68.41, -46.7 APE12-dist-out 6.407 APE11-dist-in 8.827 APE10-dist-in 4.077 APE9-dist-in 4.844 D135N,S172E None None XRAY 3.4 0.244 0.258 A 665 649 0 0 0 0 [[9, 625]] 1.0 6o8b OTHER_TBK1_HUMAN OTHER 3.4e-41 147.9 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6O8BB Q9UHD2 2 654 729.0 BX7:60701 Type1 Inactive DFGin 6.245 13.836 BLAminus DFGAsp-rot-in -162.79, -160.44 49.62, 61.03 186.9, 8.81 -82.51, 26.39 298.43, 91.64 -59.15, -28.42 in-in in 8.939 Saltbr-in 2.335 HRD-out -92.45, 101.87 -91.5, 28.16 in-out-in SNCioi out-in ActLoopNT-out 3.718 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.24, 162.25 APE9-dihe-na 143.39, -172.96 APE8-dihe-in -120.34, 144.55 APE8-rot-in 302.76 APE67-dihe-in -62.83, -22.71 -55.27, -66.45 APE12-dist-in 8.831 APE11-dist-in 9.617 APE10-dist-in 4.333 APE9-dist-in 4.238 D135N,S172E None None XRAY 3.4 0.244 0.258 B 665 653 0 0 0 0 [[9, 625]] 1.0 6o8b OTHER_TBK1_HUMAN OTHER 3.4e-41 147.9 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IM2A Q9UHD2 1 657 729.0 BX7:60701 Type1 Inactive DFGin 7.075 13.137 BLBplus DFGAsp-rot-in -136.28, 173.8 65.75, 52.9 184.34, 35.06 -107.95, 125.12 18.78, 94.0 108.02, 999.0 out-out out 12.986 Saltbr-out 11.517 HRD-out -95.3, 97.77 -57.37, -35.78 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.8 APE8-rot-none 999.0 APE67-dihe-in -56.86, -20.77 -32.3, -61.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D135N None None XRAY 2.5 0.2 0.255 A 663 616 26 0 0 16 [[9, 625]] 1.0 4im2 OTHER_TBK1_HUMAN OTHER 4.4e-41 148.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IM3A Q9UHD2 1 657 729.0 BX7:60701 Type1 Inactive DFGin 7.954 13.233 BLBplus DFGAsp-rot-in -150.28, 172.42 61.6, 53.39 185.99, 33.98 -107.06, 123.71 23.03, 90.43 -109.41, 999.0 out-out out 14.891 Saltbr-out 13.161 HRD-out -102.64, 82.39 -45.52, -34.46 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D135N None None XRAY 3.342 0.223 0.279 A 663 603 44 0 0 24 [[9, 625]] 1.0 4im3 OTHER_TBK1_HUMAN OTHER 4.4e-41 148.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IWPA Q9UHD2 2 657 729.0 BX7:60701 Type1 Inactive DFGin 7.288 13.414 None DFGAsp-rot-in -134.43, -56.21 -87.24, 102.18 186.86, 33.29 -162.15, 172.63 51.08, 85.4 74.44, 12.62 out-out out 14.153 Saltbr-out 13.317 HRD-in -97.28, -65.46 67.49, -12.98 out-out-none SNCoon out-none ActLoopNT-out 7.893 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.34 APE8-dihe-in -75.67, 146.05 APE8-rot-in 314.2 APE67-dihe-in -83.23, -17.66 -52.37, -34.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.56 S172A None None XRAY 3.065 0.283 0.335 A 659 625 22 0 0 10 [[9, 625]] 1.0 4iwp OTHER_TBK1_HUMAN OTHER 8.2e-42 149.7 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
TYR EGFR EGFR_HUMAN 9NGPA P00533 698 1018 1210.0 A1BX7:1101 Type1 None DFGin 6.167 14.553 BLAminus DFGAsp-rot-in -137.6061, -165.7411 59.368, 87.1237 201.0371, -20.9971 -103.844, 20.2902 290.0017, 98.7291 -66.9504, -6.6198 in-in in 8.088 Saltbr-in 2.592 HRD-in -79.9827, -46.422 69.693, 0.9105 in-in-none SNCiin in-none ActLoopNT-in 2.87 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 101.389 APE8-rot-na 32.6074 APE67-dihe-in -79.6247, -5.3085 -66.9439, -33.3886 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.4 0.209 0.238 A 327 281 18 0 0 14 [[712, 970]] 1.0 9ngp TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: BX7

Total number of chains: 14
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 57.1% 4EUUA
DFGin BLBplus 4 28.6% 6O8CA
DFGin BLAplus 1 7.1% 4JL9A
DFGin None 1 7.1% 4IWPA
All chains
Pymol session (all) Pymol script (all)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
OTHER TBK1 TBK1_HUMAN 4EUUA Q9UHD2 2 307 729.0 BX7:60401 Type1 Active DFGin 6.885 13.708 BLAminus DFGAsp-rot-in -149.45, -171.7 60.73, 75.15 188.74, -1.16 -94.29, 22.12 284.45, 84.57 -56.95, -31.59 in-in in 8.35 Saltbr-in 2.777 HRD-in -89.96, -55.24 75.16, 8.62 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.22, 171.79 APE9-dihe-na 116.46, -167.3 APE8-dihe-in -133.65, 129.66 APE8-rot-in 296.24 APE67-dihe-in -70.89, -19.14 -44.3, -46.34 APE12-dist-in 9.025 APE11-dist-in 10.184 APE10-dist-in 4.841 APE9-dist-in 3.409 D135N SEP172 SEP172 XRAY 1.8 0.17 0.194 A 319 306 0 0 0 0 [[9, 625]] 1.0 4euu Homo sapiens OTHER_TBK1_HUMAN OTHER 5.3e-42 150.0 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4EUUB Q9UHD2 2 307 729.0 BX7:60401 Type1 Active DFGin 6.854 13.557 BLAminus DFGAsp-rot-in -149.67, -169.25 59.25, 76.47 186.8, 3.98 -95.25, 24.67 286.86, 82.81 -60.26, -24.9 in-in in 8.312 Saltbr-in 2.823 HRD-in -94.27, -51.86 75.28, 11.95 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.26, 163.87 APE9-dihe-na 122.52, -168.66 APE8-dihe-in -132.25, 128.66 APE8-rot-in 296.78 APE67-dihe-in -66.29, -20.21 -52.98, -41.57 APE12-dist-in 9.095 APE11-dist-in 10.127 APE10-dist-in 4.813 APE9-dist-in 3.422 D135N SEP172 SEP172 XRAY 1.8 0.17 0.194 B 319 306 0 0 0 0 [[9, 625]] 1.0 4euu Homo sapiens OTHER_TBK1_HUMAN OTHER 5.3e-42 150.0 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4EUTA Q9UHD2 2 385 729.0 BX7:60401 Type1 Inactive DFGin 6.883 13.639 BLAminus DFGAsp-rot-in -159.22, -168.26 61.75, 57.03 188.04, 0.46 -82.72, 42.54 295.65, 82.26 -64.31, -31.5 in-in in 8.316 Saltbr-in 2.321 HRD-in -73.96, -54.83 84.2, -10.29 in-in-out SNCiio in-out ActLoopNT-in 3.012 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.7, 129.45 APE9-dihe-na -58.48, -57.42 APE8-dihe-in -136.66, 145.1 APE8-rot-out 88.82 APE67-dihe-in -52.88, -19.91 -92.7, -13.2 APE12-dist-out 30.135 APE11-dist-out 24.099 APE10-dist-out 26.516 APE9-dist-out 32.471 D135N None None XRAY 2.6 0.216 0.257 A 396 382 2 0 0 0 [[9, 625]] 1.0 4eut Homo sapiens OTHER_TBK1_HUMAN OTHER 9.1e-42 149.5 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4EUTB Q9UHD2 2 385 729.0 BX7:60401 Type1 Inactive DFGin 6.879 13.663 BLAminus DFGAsp-rot-in -146.55, -168.94 58.32, 68.8 182.88, 2.89 -93.86, 31.15 285.43, 84.48 -61.33, -33.63 in-in in 8.4 Saltbr-in 2.622 HRD-in -76.77, -55.1 80.6, -8.11 in-in-out SNCiio in-out ActLoopNT-in 2.984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -97.14, 115.67 APE9-dihe-na -68.94, -54.62 APE8-dihe-in -115.7, 141.18 APE8-rot-out 64.24 APE67-dihe-in -58.71, -19.7 -101.7, -8.42 APE12-dist-out 27.656 APE11-dist-out 24.127 APE10-dist-out 27.128 APE9-dist-out 33.299 D135N None None XRAY 2.6 0.216 0.257 B 396 377 7 0 0 0 [[9, 625]] 1.0 4eut Homo sapiens OTHER_TBK1_HUMAN OTHER 9.1e-42 149.5 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IW0A Q9UHD2 2 657 729.0 BX7:60701 Type1 Active DFGin 7.242 13.902 BLAminus DFGAsp-rot-in -155.36, -171.41 57.26, 68.28 187.09, 20.13 -92.34, 33.21 293.18, 94.33 -70.66, -23.63 in-in in 9.43 Saltbr-in 2.462 HRD-in -106.67, -50.47 63.21, 19.01 in-in-in SNCiii in-in ActLoopNT-in 3.397 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.9, 153.67 APE9-dihe-na 126.79, 169.6 APE8-dihe-in -88.95, 160.27 APE8-rot-in 323.58 APE67-dihe-in -68.26, -28.77 -61.06, -59.04 APE12-dist-in 9.098 APE11-dist-in 9.878 APE10-dist-in 4.64 APE9-dist-in 3.211 D135N SEP172 SEP172 XRAY 4.0 0.24 0.291 A 658 646 0 0 0 0 [[9, 625]] 1.0 4iw0 Homo sapiens OTHER_TBK1_HUMAN OTHER 1.7e-41 148.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6O8BA Q9UHD2 2 656 729.0 BX7:60701 Type1 Inactive DFGin 8.024 14.156 BLAminus DFGAsp-rot-in -167.16, -174.99 52.37, 56.07 185.52, 18.9 -72.25, 60.65 314.15, 135.49 -69.84, -26.09 out-out out 13.196 Saltbr-out 9.426 HRD-in -76.99, -64.92 59.52, 19.15 out-in-out SNCoio in-out ActLoopNT-in 3.414 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiii APE10-dihe-na -154.01, 141.29 APE9-dihe-na 147.45, -177.44 APE8-dihe-in -109.41, 155.1 APE8-rot-out 222.95 APE67-dihe-in -65.05, -44.47 -68.41, -46.7 APE12-dist-out 6.407 APE11-dist-in 8.827 APE10-dist-in 4.077 APE9-dist-in 4.844 D135N,S172E None None XRAY 3.4 0.244 0.258 A 665 649 0 0 0 0 [[9, 625]] 1.0 6o8b Homo sapiens OTHER_TBK1_HUMAN OTHER 3.4e-41 147.9 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6O8BB Q9UHD2 2 654 729.0 BX7:60701 Type1 Inactive DFGin 6.245 13.836 BLAminus DFGAsp-rot-in -162.79, -160.44 49.62, 61.03 186.9, 8.81 -82.51, 26.39 298.43, 91.64 -59.15, -28.42 in-in in 8.939 Saltbr-in 2.335 HRD-out -92.45, 101.87 -91.5, 28.16 in-out-in SNCioi out-in ActLoopNT-out 3.718 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.24, 162.25 APE9-dihe-na 143.39, -172.96 APE8-dihe-in -120.34, 144.55 APE8-rot-in 302.76 APE67-dihe-in -62.83, -22.71 -55.27, -66.45 APE12-dist-in 8.831 APE11-dist-in 9.617 APE10-dist-in 4.333 APE9-dist-in 4.238 D135N,S172E None None XRAY 3.4 0.244 0.258 B 665 653 0 0 0 0 [[9, 625]] 1.0 6o8b Homo sapiens OTHER_TBK1_HUMAN OTHER 3.4e-41 147.9 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IM2A Q9UHD2 1 657 729.0 BX7:60701 Type1 Inactive DFGin 7.075 13.137 BLBplus DFGAsp-rot-in -136.28, 173.8 65.75, 52.9 184.34, 35.06 -107.95, 125.12 18.78, 94.0 108.02, 999.0 out-out out 12.986 Saltbr-out 11.517 HRD-out -95.3, 97.77 -57.37, -35.78 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.8 APE8-rot-none 999.0 APE67-dihe-in -56.86, -20.77 -32.3, -61.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D135N None None XRAY 2.5 0.2 0.255 A 663 616 26 0 0 16 [[9, 625]] 1.0 4im2 Homo sapiens OTHER_TBK1_HUMAN OTHER 4.4e-41 148.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IM3A Q9UHD2 1 657 729.0 BX7:60701 Type1 Inactive DFGin 7.954 13.233 BLBplus DFGAsp-rot-in -150.28, 172.42 61.6, 53.39 185.99, 33.98 -107.06, 123.71 23.03, 90.43 -109.41, 999.0 out-out out 14.891 Saltbr-out 13.161 HRD-out -102.64, 82.39 -45.52, -34.46 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D135N None None XRAY 3.342 0.223 0.279 A 663 603 44 0 0 24 [[9, 625]] 1.0 4im3 Homo sapiens OTHER_TBK1_HUMAN OTHER 4.4e-41 148.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IWPA Q9UHD2 2 657 729.0 BX7:60701 Type1 Inactive DFGin 7.288 13.414 None DFGAsp-rot-in -134.43, -56.21 -87.24, 102.18 186.86, 33.29 -162.15, 172.63 51.08, 85.4 74.44, 12.62 out-out out 14.153 Saltbr-out 13.317 HRD-in -97.28, -65.46 67.49, -12.98 out-out-none SNCoon out-none ActLoopNT-out 7.893 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.34 APE8-dihe-in -75.67, 146.05 APE8-rot-in 314.2 APE67-dihe-in -83.23, -17.66 -52.37, -34.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.56 S172A None None XRAY 3.065 0.283 0.335 A 659 625 22 0 0 10 [[9, 625]] 1.0 4iwp Homo sapiens OTHER_TBK1_HUMAN OTHER 8.2e-42 149.7 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
TYR EGFR EGFR_HUMAN 9NGPA P00533 698 1018 1210.0 A1BX7:1101 Type1 None DFGin 6.167 14.553 BLAminus DFGAsp-rot-in -137.6061, -165.7411 59.368, 87.1237 201.0371, -20.9971 -103.844, 20.2902 290.0017, 98.7291 -66.9504, -6.6198 in-in in 8.088 Saltbr-in 2.592 HRD-in -79.9827, -46.422 69.693, 0.9105 in-in-none SNCiin in-none ActLoopNT-in 2.87 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 101.389 APE8-rot-na 32.6074 APE67-dihe-in -79.6247, -5.3085 -66.9439, -33.3886 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.4 0.209 0.238 A 327 281 18 0 0 14 [[712, 970]] 1.0 9ngp Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
OTHER TBK1 TBK1_MOUSE 4JL9A Q9WUN2 2 656 729.0 BX7:60701 Type1 Inactive DFGin 6.919 12.683 BLAplus DFGAsp-rot-in -138.0, 178.5 57.92, 67.1 187.49, 76.35 -136.47, -32.02 43.45, 79.55 -75.87, -25.93 out-out out 13.149 Saltbr-out 10.037 HRD-out -66.41, 148.0 -111.76, -49.06 out-out-out SNCooo out-out ActLoopNT-out 10.325 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 67.22 APE8-dihe-out -104.51, 12.79 APE8-rot-in 322.0 APE67-dihe-in -86.97, 29.44 -60.15, -49.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 26.149 None None None XRAY 3.1 0.231 0.269 A 657 644 7 0 0 7 [[9, 625]] 1.0 4jl9 Mus musculus OTHER_TBK1_MOUSE OTHER 4.1e-42 151.8 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_MOUSE 6O8CA Q9WUN2 2 651 729.0 BX7:60701 Type1 Inactive DFGin 6.351 13.655 BLBplus DFGAsp-rot-in -168.96, 167.59 66.57, 53.71 194.46, 26.16 -125.53, 131.95 44.25, 87.0 -63.6, 176.49 out-out out 13.097 Saltbr-out 8.676 HRD-out -103.81, 139.46 -86.83, 19.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -156.17 APE8-rot-out 174.96 APE67-dihe-out -111.09, 3.21 84.18, -22.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S172A None None XRAY 3.17 0.214 0.231 A 665 630 14 0 0 14 [[9, 625]] 1.0 6o8c Mus musculus OTHER_TBK1_MOUSE OTHER 1.1e-41 150.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_MOUSE 6O8CB Q9WUN2 2 653 729.0 BX7:60701 Type1 Inactive DFGin 6.581 13.447 BLBplus DFGAsp-rot-in -169.0, 172.78 75.03, 43.09 193.76, 27.81 -126.0, 152.08 53.16, 82.35 -96.05, -164.51 out-out out 12.863 Saltbr-out 7.061 HRD-out -152.89, 105.64 -106.44, -11.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -155.61 APE8-dihe-out -81.91, 14.01 APE8-rot-in 315.32 APE67-dihe-out -99.5, -7.86 76.01, -32.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 32.967 S172A None None XRAY 3.17 0.214 0.231 B 665 638 14 0 0 14 [[9, 625]] 1.0 6o8c Mus musculus OTHER_TBK1_MOUSE OTHER 1.1e-41 150.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1

Ligand: BX7

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 2 66.7% 6O8CA
DFGin BLAplus 1 33.3% 4JL9A
All chains
Pymol session (all) Pymol script (all)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
OTHER TBK1 TBK1_MOUSE 4JL9A Q9WUN2 2 656 729.0 BX7:60701 Type1 Inactive DFGin 6.919 12.683 BLAplus DFGAsp-rot-in -138.0, 178.5 57.92, 67.1 187.49, 76.35 -136.47, -32.02 43.45, 79.55 -75.87, -25.93 out-out out 13.149 Saltbr-out 10.037 HRD-out -66.41, 148.0 -111.76, -49.06 out-out-out SNCooo out-out ActLoopNT-out 10.325 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 67.22 APE8-dihe-out -104.51, 12.79 APE8-rot-in 322.0 APE67-dihe-in -86.97, 29.44 -60.15, -49.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 26.149 None None None XRAY 3.1 0.231 0.269 A 657 644 7 0 0 7 [[9, 625]] 1.0 4jl9 Mus musculus OTHER_TBK1_MOUSE OTHER 4.1e-42 151.8 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_MOUSE 6O8CA Q9WUN2 2 651 729.0 BX7:60701 Type1 Inactive DFGin 6.351 13.655 BLBplus DFGAsp-rot-in -168.96, 167.59 66.57, 53.71 194.46, 26.16 -125.53, 131.95 44.25, 87.0 -63.6, 176.49 out-out out 13.097 Saltbr-out 8.676 HRD-out -103.81, 139.46 -86.83, 19.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -156.17 APE8-rot-out 174.96 APE67-dihe-out -111.09, 3.21 84.18, -22.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S172A None None XRAY 3.17 0.214 0.231 A 665 630 14 0 0 14 [[9, 625]] 1.0 6o8c Mus musculus OTHER_TBK1_MOUSE OTHER 1.1e-41 150.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_MOUSE 6O8CB Q9WUN2 2 653 729.0 BX7:60701 Type1 Inactive DFGin 6.581 13.447 BLBplus DFGAsp-rot-in -169.0, 172.78 75.03, 43.09 193.76, 27.81 -126.0, 152.08 53.16, 82.35 -96.05, -164.51 out-out out 12.863 Saltbr-out 7.061 HRD-out -152.89, 105.64 -106.44, -11.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -155.61 APE8-dihe-out -81.91, 14.01 APE8-rot-in 315.32 APE67-dihe-out -99.5, -7.86 76.01, -32.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 32.967 S172A None None XRAY 3.17 0.214 0.231 B 665 638 14 0 0 14 [[9, 625]] 1.0 6o8c Mus musculus OTHER_TBK1_MOUSE OTHER 1.1e-41 150.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1