Ligand: AXI (Axitinib)

Total number of chains: 6
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 33.3% 4TWPB
DFGout BBAminus 2 33.3% 4AG8A
DFGout None 1 16.7% 4WA9B
None None 1 16.7% 4WA9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR ABL1 ABL1_HUMAN 4TWPA 2.4 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AXI Type1 233 - 503 0 None T315I Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4TWPB 2.4 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AXI Type1 233 - 503 0 None T315I Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4WA9B 2.2 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai AXI Type1 246 - 508 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4WA9A 2.2 Inactive None‑None none-none out-in TYR APEdihe_iiiai APEdist_aaai AXI Type1 246 - 504 0 None None Tyrosine-protein kinase ABL1
TYR KDR VGFR2_HUMAN 4AG8A 1.95 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai AXI Type1 816 - 1168 0 None E990V Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 4AGCA 2.0 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai AXI Type1.5_Back 801 - 1169 0 None E990V Vascular endothelial growth factor receptor 2

Ligand: AXI (Axitinib)

Total number of chains: 6
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 33.3% 4TWPB
DFGout BBAminus 2 33.3% 4AG8A
DFGout None 1 16.7% 4WA9B
None None 1 16.7% 4WA9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR ABL1 ABL1_HUMAN 4TWPA 2.4 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AXI Type1 233 - 503 0 None T315I Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 4TWPB 2.4 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AXI Type1 233 - 503 0 None T315I Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 4WA9B 2.2 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai AXI Type1 246 - 508 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 4WA9A 2.2 Inactive None‑None none-none out-in TYR APEdihe_iiiai APEdist_aaai AXI Type1 246 - 504 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR KDR VGFR2_HUMAN 4AG8A 1.95 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai AXI Type1 816 - 1168 0 None E990V Vascular endothelial growth factor receptor 2 Homo sapiens
TYR KDR VGFR2_HUMAN 4AGCA 2.0 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai AXI Type1.5_Back 801 - 1169 0 None E990V Vascular endothelial growth factor receptor 2 Homo sapiens

Ligand: AXI (Axitinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism